ZA845490B - Imidazole derivatives,processes for their preparation and pharmaceutical compositions thereof - Google Patents
Imidazole derivatives,processes for their preparation and pharmaceutical compositions thereofInfo
- Publication number
- ZA845490B ZA845490B ZA845490A ZA845490A ZA845490B ZA 845490 B ZA845490 B ZA 845490B ZA 845490 A ZA845490 A ZA 845490A ZA 845490 A ZA845490 A ZA 845490A ZA 845490 B ZA845490 B ZA 845490B
- Authority
- ZA
- South Africa
- Prior art keywords
- group
- substituted
- alkyl
- pharmaceutical compositions
- processes
- Prior art date
Links
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 150000002460 imidazoles Chemical class 0.000 title 1
- 229940079865 intestinal antiinfectives imidazole derivative Drugs 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 5
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 2
- 125000005843 halogen group Chemical group 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 125000006273 (C1-C3) alkyl group Chemical group 0.000 abstract 1
- 125000006595 (C1-C3) alkylsulfinyl group Chemical group 0.000 abstract 1
- 125000004455 (C1-C3) alkylthio group Chemical group 0.000 abstract 1
- 125000006274 (C1-C3)alkoxy group Chemical group 0.000 abstract 1
- -1 2-substituted 4-phenylimidazole Chemical class 0.000 abstract 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
- 239000005864 Sulphur Substances 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000004442 acylamino group Chemical group 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000004390 alkyl sulfonyl group Chemical group 0.000 abstract 1
- 125000000304 alkynyl group Chemical group 0.000 abstract 1
- 150000001409 amidines Chemical class 0.000 abstract 1
- 125000003277 amino group Chemical group 0.000 abstract 1
- 125000004397 aminosulfonyl group Chemical group NS(=O)(=O)* 0.000 abstract 1
- 239000003699 antiulcer agent Substances 0.000 abstract 1
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 230000027119 gastric acid secretion Effects 0.000 abstract 1
- 125000005842 heteroatom Chemical group 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 239000003485 histamine H2 receptor antagonist Substances 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000003396 thiol group Chemical group [H]S* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/68—Halogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/70—One oxygen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/84—Sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/88—Nitrogen atoms, e.g. allantoin
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Treatment Of Sludge (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Processing Of Solid Wastes (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Solid-Sorbent Or Filter-Aiding Compositions (AREA)
Abstract
Object of the present invention are new pharmacologically active amidine derivatives of 2-substituted 4-phenylimidazole of formula
<CHEM>
in which R representa a linear or branched alkyl group, a hydroxy group, a C1-3 alkoxy group, a mercapto group, C1-3 alkylthio group, a halogen atom, a C1-3 alkylsulfinyl or alkylsulfonyl group, a sulfamoyl group, an amino group which may be substituted by one or two alkyl groups having 1 to 3 carbon atoms, an acylamino group or a phenyl group; R1 and R2, which may be the same or different, represent a hydrogen atom or an alkyl group; R3 represents a linear or branched alkyl group containing optionally one heteroatom such as an oxygen, a sulphur or a nitrogen atom, an alkenyl group, an alkynyl group, a cyano group, an aryl or an aralkyl group optionally substituted, a cycloalkyl or cycloaliphatic alkyl group, a substituted or unsubstituted heterocyclilalkyl or heterocyclic group; R4 represents a hydrogen atom, a C1-3 alkyl or alkoxy group, a halogen atom, a cyano or carbamoyl group, tautomeric forms thereof and acid addition salts thereof.
<??>Processes for the preparation of the compounds of formula (1) and their intermediates as well as the pharmaceutical compositions containing them are also object of this invention.
<??>The new compounds are H2-receptor blocking agents which inhibit the gastric acid secretion and are useful antiulcer agents.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT8322110A IT1206498B (en) | 1983-07-18 | 1983-07-18 | AMIDINE DERIVATIVES OF 4-PHENYLMIDAZOLE 2-SUBSTITUTE PROCESSES FOR THEIR PREPARATION AND THEIR PHARMACEUTICAL USE. |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA845490B true ZA845490B (en) | 1986-03-26 |
Family
ID=11191639
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA845490A ZA845490B (en) | 1983-07-18 | 1984-07-17 | Imidazole derivatives,processes for their preparation and pharmaceutical compositions thereof |
Country Status (28)
| Country | Link |
|---|---|
| US (1) | US4649150A (en) |
| EP (1) | EP0131973B1 (en) |
| JP (1) | JPS6038367A (en) |
| KR (1) | KR910000661B1 (en) |
| AT (1) | ATE45149T1 (en) |
| AU (1) | AU565292B2 (en) |
| CA (1) | CA1257274A (en) |
| CS (1) | CS244141B2 (en) |
| DD (1) | DD232696A5 (en) |
| DE (1) | DE3479212D1 (en) |
| DK (1) | DK350084A (en) |
| ES (2) | ES8505962A1 (en) |
| FI (1) | FI842432A7 (en) |
| GB (1) | GB2149395B (en) |
| GR (1) | GR79981B (en) |
| HK (1) | HK74287A (en) |
| HU (1) | HU193292B (en) |
| IL (1) | IL72417A (en) |
| IT (1) | IT1206498B (en) |
| NO (1) | NO162857C (en) |
| NZ (1) | NZ208920A (en) |
| PH (1) | PH21566A (en) |
| PL (2) | PL143732B1 (en) |
| PT (1) | PT78935B (en) |
| SG (1) | SG48687G (en) |
| SU (2) | SU1322979A3 (en) |
| YU (2) | YU43367B (en) |
| ZA (1) | ZA845490B (en) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4888348A (en) * | 1986-09-04 | 1989-12-19 | Ciba-Geigy Corporation | Substituted thioureas, isothioureas and carbodiimides |
| AU744297B2 (en) | 1997-07-03 | 2002-02-21 | Neurogen Corporation | Certain diarylimidazole derivatives; a new class of NPY specific ligands |
| US6887870B1 (en) | 1999-10-12 | 2005-05-03 | Bristol-Myers Squibb Company | Heterocyclic sodium/proton exchange inhibitors and method |
| HUP0301218A2 (en) | 1999-12-16 | 2003-08-28 | Schering Corp. | Substituted imidazole neuropeptide y y5 receptor antagonists their use and pharmaceutical compositions containing them |
| FR2917087B1 (en) | 2007-06-05 | 2012-09-21 | Galderma Res & Dev | NOVEL 4-PHENYL-IMIDAZOLE-2-THIONES AS INHIBITORS OF TYROSINASE, PROCESS FOR THEIR PREPARATION AND THEIR USE IN HUMAN MEDICINE AND COSMETICS |
| EP4196793A1 (en) | 2020-08-11 | 2023-06-21 | Université de Strasbourg | H2 blockers targeting liver macrophages for the prevention and treatment of liver disease and cancer |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1209431B (en) * | 1980-11-28 | 1989-07-16 | Angeli Inst Spa | IMIDAZOLYLPHENYL AMIDINE, PROCESSES FOR THEIR PREPARATION AND PHARMACEUTICAL USE, AND INTERMEDIATE PREPARATION. |
-
1983
- 1983-07-18 IT IT8322110A patent/IT1206498B/en active
-
1984
- 1984-05-08 DE DE8484200659T patent/DE3479212D1/en not_active Expired
- 1984-05-08 AT AT84200659T patent/ATE45149T1/en not_active IP Right Cessation
- 1984-05-08 EP EP84200659A patent/EP0131973B1/en not_active Expired
- 1984-05-16 US US06/610,958 patent/US4649150A/en not_active Expired - Fee Related
- 1984-06-15 FI FI842432A patent/FI842432A7/en not_active Application Discontinuation
- 1984-07-02 YU YU1154/84A patent/YU43367B/en unknown
- 1984-07-09 JP JP59142099A patent/JPS6038367A/en active Pending
- 1984-07-11 PH PH30966A patent/PH21566A/en unknown
- 1984-07-16 KR KR1019840004177A patent/KR910000661B1/en not_active Expired
- 1984-07-16 PL PL1984254625A patent/PL143732B1/en unknown
- 1984-07-16 PL PL1984248779A patent/PL143303B1/en unknown
- 1984-07-16 DD DD84265319A patent/DD232696A5/en unknown
- 1984-07-16 IL IL72417A patent/IL72417A/en unknown
- 1984-07-17 CA CA000459030A patent/CA1257274A/en not_active Expired
- 1984-07-17 ES ES534375A patent/ES8505962A1/en not_active Expired
- 1984-07-17 DK DK350084A patent/DK350084A/en not_active Application Discontinuation
- 1984-07-17 SU SU843770847A patent/SU1322979A3/en active
- 1984-07-17 HU HU842781A patent/HU193292B/en not_active IP Right Cessation
- 1984-07-17 ZA ZA845490A patent/ZA845490B/en unknown
- 1984-07-17 ES ES534376A patent/ES8601910A1/en not_active Expired
- 1984-07-17 GB GB08418149A patent/GB2149395B/en not_active Expired
- 1984-07-17 GR GR75327A patent/GR79981B/el unknown
- 1984-07-17 NO NO842921A patent/NO162857C/en unknown
- 1984-07-17 NZ NZ208920A patent/NZ208920A/en unknown
- 1984-07-18 PT PT78935A patent/PT78935B/en unknown
- 1984-07-18 CS CS845542A patent/CS244141B2/en unknown
- 1984-07-18 AU AU30800/84A patent/AU565292B2/en not_active Ceased
-
1985
- 1985-01-29 SU SU853844125A patent/SU1313345A3/en active
-
1986
- 1986-06-26 YU YU1126/86A patent/YU43701B/en unknown
-
1987
- 1987-06-03 SG SG486/87A patent/SG48687G/en unknown
- 1987-10-15 HK HK742/87A patent/HK74287A/en unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DE3479212D1 (en) | New amidine derivatives of 2-substituted 4-phenilimidazole | |
| AU562246B2 (en) | Hetero substituted phenyl formamidines |