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WO2006050091A3 - Bioactive wound dressings and implantable devices and methods of use - Google Patents

Bioactive wound dressings and implantable devices and methods of use Download PDF

Info

Publication number
WO2006050091A3
WO2006050091A3 PCT/US2005/038925 US2005038925W WO2006050091A3 WO 2006050091 A3 WO2006050091 A3 WO 2006050091A3 US 2005038925 W US2005038925 W US 2005038925W WO 2006050091 A3 WO2006050091 A3 WO 2006050091A3
Authority
WO
WIPO (PCT)
Prior art keywords
wound dressings
dispersed
methods
precursor cells
conditioned medium
Prior art date
Application number
PCT/US2005/038925
Other languages
French (fr)
Other versions
WO2006050091A2 (en
Inventor
Kenneth W Carpenter
William G Turnell
Kristin M Defife
Kathryn A Grako
Original Assignee
Medivas Llc
Kenneth W Carpenter
William G Turnell
Kristin M Defife
Kathryn A Grako
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Medivas Llc, Kenneth W Carpenter, William G Turnell, Kristin M Defife, Kathryn A Grako filed Critical Medivas Llc
Priority to EP05825008A priority Critical patent/EP1809310A4/en
Priority to JP2007539165A priority patent/JP2008518666A/en
Priority to CA002585740A priority patent/CA2585740A1/en
Priority to AU2005302469A priority patent/AU2005302469A1/en
Publication of WO2006050091A2 publication Critical patent/WO2006050091A2/en
Priority to US11/796,267 priority patent/US7794706B2/en
Publication of WO2006050091A3 publication Critical patent/WO2006050091A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/22—Urine; Urinary tract, e.g. kidney or bladder; Intraglomerular mesangial cells; Renal mesenchymal cells; Adrenal gland
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/36—Skin; Hair; Nails; Sebaceous glands; Cerumen; Epidermis; Epithelial cells; Keratinocytes; Langerhans cells; Ectodermal cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/40—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing ingredients of undetermined constitution or reaction products thereof, e.g. plant or animal extracts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/42—Use of materials characterised by their function or physical properties
    • A61L15/60—Liquid-swellable gel-forming materials, e.g. super-absorbents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
    • A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
    • A61L26/0023—Polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
    • A61L26/0057—Ingredients of undetermined constitution or reaction products thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
    • A61L26/0061—Use of materials characterised by their function or physical properties
    • A61L26/008—Hydrogels or hydrocolloids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/005—Ingredients of undetermined constitution or reaction products thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L31/145—Hydrogels or hydrocolloids

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Cell Biology (AREA)
  • Materials Engineering (AREA)
  • Zoology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Immunology (AREA)
  • Dispersion Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Virology (AREA)
  • Medicinal Chemistry (AREA)
  • Vascular Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Surgery (AREA)
  • Dermatology (AREA)
  • Urology & Nephrology (AREA)
  • Botany (AREA)
  • Materials For Medical Uses (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

The present invention provides wound dressings, optionally surgically implantable, containing biodegradable, polymers and hydrogels having allogenic or autologous precursor cells, such as stem cells and progenitor cells dispersed within. Alternatively, the wound dressings can have conditioned medium obtained from the precursor cells dispersed within. The wound dressings promote tissue restoration processes at a site of application or implantation. Additional bioactive agents can also be dispersed within the polymer/hydrogel matrix, which can be formulated to biodegrade at a controlled rate by adjusting the composition. Methods are also provided for using such biodegradable wound dressings as a delivery device or carrier for the precursor cells, conditioned medium and bioactive agents, or as coatings on implantable medical devices, to promote tissue restoration at a lesion site.
PCT/US2005/038925 2003-10-14 2005-10-27 Bioactive wound dressings and implantable devices and methods of use WO2006050091A2 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
EP05825008A EP1809310A4 (en) 2004-10-28 2005-10-27 Bioactive wound dressings and implantable devices and methods of use
JP2007539165A JP2008518666A (en) 2004-10-28 2005-10-27 Bioactive wound dressings and implantable devices and methods of use
CA002585740A CA2585740A1 (en) 2004-10-28 2005-10-27 Bioactive wound dressings and implantable devices and methods of use
AU2005302469A AU2005302469A1 (en) 2004-10-28 2005-10-27 Bioactive wound dressings and implantable devices and methods of use
US11/796,267 US7794706B2 (en) 2003-10-14 2007-04-26 Bioactive wound dressings and implantable devices and methods of use

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US62344604P 2004-10-28 2004-10-28
US60/623,446 2004-10-28

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
US10/362,848 Continuation-In-Part US7304122B2 (en) 2000-08-30 2001-08-30 Elastomeric functional biodegradable copolyester amides and copolyester urethanes

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US11/796,267 Continuation-In-Part US7794706B2 (en) 2003-10-14 2007-04-26 Bioactive wound dressings and implantable devices and methods of use

Publications (2)

Publication Number Publication Date
WO2006050091A2 WO2006050091A2 (en) 2006-05-11
WO2006050091A3 true WO2006050091A3 (en) 2009-04-09

Family

ID=36319671

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2005/038925 WO2006050091A2 (en) 2003-10-14 2005-10-27 Bioactive wound dressings and implantable devices and methods of use

Country Status (6)

Country Link
EP (1) EP1809310A4 (en)
JP (1) JP2008518666A (en)
CN (1) CN101437528A (en)
AU (1) AU2005302469A1 (en)
CA (1) CA2585740A1 (en)
WO (1) WO2006050091A2 (en)

Families Citing this family (26)

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US20060177416A1 (en) * 2003-10-14 2006-08-10 Medivas, Llc Polymer particle delivery compositions and methods of use
WO2007035938A2 (en) 2005-09-22 2007-03-29 Medivas, Llc BIS-(α-AMINO)-DIOL-DIESTER-CONTAINING POLY(ESTER AMIDE) AND POLY(ESTER URETHANE) COMPOSITIONS AND METHODS OF USE
EP1933881B1 (en) 2005-09-22 2019-03-13 Medivas, LLC Solid polymer delivery compositions and methods for use thereof
US7771739B2 (en) 2006-06-30 2010-08-10 Abbott Cardiovascular Systems Inc. Implantable medical devices comprising semi-crystalline poly(ester-amide)
JP2010502822A (en) * 2006-09-05 2010-01-28 メディバス エルエルシー Polymer stabilized liposome compositions and methods of use
DK2578081T3 (en) 2006-10-11 2016-06-27 Massachusetts Gen Hospital Compositions, methods and devices for the treatment of liver disease
NZ582616A (en) * 2007-06-15 2012-07-27 Garnet Biotherapeutics Inc Treatment of diseases and disorders using self-renewing colony forming cells cultured and expanded in vitro
US20110020291A1 (en) * 2007-11-17 2011-01-27 Debrabrata Banerjee Use of stem cells for wound healing
RU2394593C2 (en) * 2008-09-25 2010-07-20 Андрей Степанович БРЮХОВЕЦКИЙ Implanted neuroendoprosthetic system, method of obtaining it and method of carrying out reconstructive neurosurgical operation
AU2010347212B2 (en) * 2010-09-14 2016-07-14 Cell Ideas Pty Ltd Cell free preparation and uses thereof
JP6135870B2 (en) * 2011-05-02 2017-05-31 ディーエスエム アイピー アセッツ ビー．ブイ． Fiber containing biodegradable polymer
EP2723800B1 (en) 2011-06-23 2015-10-07 DSM IP Assets B.V. Micro- or nanoparticles comprising a biodegradable polyesteramide copolymer for use in the delivery of bioactive agents
US9873765B2 (en) 2011-06-23 2018-01-23 Dsm Ip Assets, B.V. Biodegradable polyesteramide copolymers for drug delivery
JP6303199B2 (en) * 2012-10-24 2018-04-04 ディーエスエム アイピー アセッツ ビー．ブイ． Fibers containing polyesteramide copolymers for drug delivery
WO2015154924A1 (en) * 2014-04-08 2015-10-15 Dsm Ip Assets B.V. Biodegradable polyesteramide used for the treatment of arthritic disorders
JP6338468B2 (en) * 2014-06-19 2018-06-06 テルモ株式会社 Method for producing gel in which cells are dispersed and cell-dispersed gel produced by the method
WO2016097297A1 (en) 2014-12-18 2016-06-23 Dsm Ip Assets B.V. Drug delivery system for delivery of acid sensitive drugs
US9238090B1 (en) 2014-12-24 2016-01-19 Fettech, Llc Tissue-based compositions
CN105079859B (en) * 2015-08-20 2018-01-26 广州赛莱拉干细胞科技股份有限公司 A kind of dressing and preparation method thereof
US10322034B1 (en) 2015-09-04 2019-06-18 University Of South Florida Hydrocolloid dressing for precise nipple positioning after nipple- or skin-sparing mastectomy
EP3402544B1 (en) * 2016-01-17 2022-12-07 Guoming Sun Biocompatible polysaccharide hydrogels and methods of usage
CN105709270B (en) * 2016-03-18 2019-01-01 中国科学院长春应用化学研究所 A kind of aerogel dressing for stem-cell therapy
CN106581763A (en) * 2016-12-28 2017-04-26 溯源生命科技股份有限公司 Method for preparing stem cell human miniature organs
US11345884B2 (en) * 2017-03-31 2022-05-31 Cellum Biomedical, Inc. Biocompatible conditioned cell medium compositions and uses thereof
CN107261213A (en) * 2017-06-13 2017-10-20 北京恒峰铭成生物科技有限公司 A kind of active hydrogel and preparation method thereof and the application in operation wound reparation
GB2586577B (en) * 2019-06-14 2024-03-27 Gelmetix Ltd Diagnosis and treatment

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WO2002018477A2 (en) * 2000-08-30 2002-03-07 Cornell Research Foundation, Inc. Elastomeric functional biodegradable copolyester amides and copolyester urethanes

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WO2002018477A2 (en) * 2000-08-30 2002-03-07 Cornell Research Foundation, Inc. Elastomeric functional biodegradable copolyester amides and copolyester urethanes

Non-Patent Citations (3)

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Title
CHUNMENG ET AL.: "Effects of Dermal Multipotent Cell Transplantation on Skin Wound Healing.", JOURNAL OF SURGICAL RESEARCH., vol. 121, September 2004 (2004-09-01), pages 13 - 19, XP002495102, DOI: doi:10.1016/j.jss.2004.04.008 *
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YAMAGUCHI ET AL.: "Bone marrow cells differenitate into wound myofibroblasts and accelerate the healing of wounds with exposed bones when combined with an occlusive dressing.", BRITISH JOURNAL OF DERMATOLOGY., vol. 152, 2005, pages 616 - 622, XP008119299 *

Also Published As

Publication number Publication date
JP2008518666A (en) 2008-06-05
CN101437528A (en) 2009-05-20
WO2006050091A2 (en) 2006-05-11
EP1809310A2 (en) 2007-07-25
AU2005302469A1 (en) 2006-05-11
CA2585740A1 (en) 2006-05-11
EP1809310A4 (en) 2011-10-26

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