WO2002043632A1 - A device for sealing the capsular bag of an eye and a method for delivering fluid or treatment substances to the lens of an eye - Google Patents
A device for sealing the capsular bag of an eye and a method for delivering fluid or treatment substances to the lens of an eye Download PDFInfo
- Publication number
- WO2002043632A1 WO2002043632A1 PCT/AU2001/001554 AU0101554W WO0243632A1 WO 2002043632 A1 WO2002043632 A1 WO 2002043632A1 AU 0101554 W AU0101554 W AU 0101554W WO 0243632 A1 WO0243632 A1 WO 0243632A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- plug
- capsular bag
- eye
- irrigation
- capsule
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F9/00—Methods or devices for treatment of the eyes; Devices for putting-in contact lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
- A61F9/007—Methods or devices for eye surgery
- A61F9/00736—Instruments for removal of intra-ocular material or intra-ocular injection, e.g. cataract instruments
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F9/00—Methods or devices for treatment of the eyes; Devices for putting-in contact lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
- A61F9/0008—Introducing ophthalmic products into the ocular cavity or retaining products therein
- A61F9/0017—Introducing ophthalmic products into the ocular cavity or retaining products therein implantable in, or in contact with, the eye, e.g. ocular inserts
Definitions
- the invention pertains to surgical devices and methods and more particularly to devices and methods for the prevention of posterior capsule opacification following cataract surgery.
- BACKGROUND ART During cataract surgery, the human lens is removed from within the lens capsule and replaced by an artificial lens. This is performed by opening a small hole in the anterior capsule (a capsulorhexis) and then destroying and removing the human lens by phacoemulsification.
- lens cortex and epithelial cells remain following the lens removal, and irrigation / aspiration is routinely used to remove the visible cortex remnants. It is unreasonable to expect all lens epithelial cells (LECs) which are bound to both the anterior and posterior capsule to be removed by this method.
- LECs lens epithelial cells
- the current treatment for PCO is a Posterior Capsulotomy using a Yag laser. Although the complication associated with this procedure is small, the cost is significant and there is a risk of retinal detachment.
- cytotoxic chemicals can be used to destroy these epithelial cells, however, there is a risk that these chemicals damage other intranuclear structures.
- the invention provides devices and methods for the transfer of fluids and potentially toxic chemicals into the lens capsule by creating a closed system preventing the fluids from entering the anterior chamber of the eye and thus preventing damage to other ocular structures.
- the invention comprises one or more fluid conduits which communicate with a plug which maybe inserted through the corneal incision and placed onto the anterior surface of the capsule around the capsulorhexis.
- the plug is adapted to seal against the anterior surface of the lens capsule.
- the flow of fluids into and out of the plug are controlled from a separate fluid flow controller.
- Figs. 1 and 1(a) are schematic cross sections H)ustrattng the plug and the lumens which carry fluids and vacuum,
- Fig. 2 is a partially sectioned interior view of the plug illustrating an inclined, tangential fluid inlet
- Figs. 3 and 3(a) are schematic cross sections illustrating a mechanical engagement between a capsular plug and a capsule
- Figs. 4 and 4(a) illustrate the use of an inflatable seal between the capsule and the plug
- Fig. 5 is a schematic, cross-sectional, side view of an eye showing a first embodiment of a device according to the invention in use
- Fig. 6 is a schematic, cross-sectional view of the device shown in Fig. 5
- Fig. 7 is a schematic, partial, cross-sectional end view of the device shown in Fig. 6
- Fig. 8 is a schematic side view of the device within a delivery tube before use
- FIG. 9 shows the device and delivery tube shown in Fig. 8 during use
- Fig. 10 shows the device and delivery tube shown in Figs. 8 and 9 after use
- Fig. 11 is a schematic, cross-sectional, side view of an eye showing a second embodiment of a device according to the invention in use
- Fig. 12 is a schematic, cross-sectional, side view of the device shown in
- Fig. 1 and Fig. 13 is a schematic, cross-sectional, end view of the device shown in Fig. 12.
- a first embodiment of the invention comprises a flexible plug 10 which can be inserted through the corneal incision and placed onto the anterior surface 11 of the capsule 12 and around the capsulorhexis
- the plug 10 is preferably attached to the anterior surface 11 around the rhexis 13 by a vacuum seal 14.
- the vacuum seal 14 comprises a circumferential groove 15 which communicates with a lumen 16 which communicates controlled vacuum pressure and extends through the corneal incision.
- the vacuum seal is generally circumferential comprising an inverted "v" shaped groove, defined in part by flexible sealing lips 17.
- Fluid is introduced into and removed from the plug and capsule by the second and third lumens 18, 19.
- the second lumen 18 is for the aspiration of fluid and leads to an aspiration opening 20 preferably formed at the highest interior point of the plug 10.
- An aspiration lumen may have a larger internal diameter (ID) than an irrigation lumen.
- the aspiration port 20 can be covered by a screen or castellation which prevents the aspiration port from sealing against the capsule and blocking the flow of fluid.
- a conduit which extends from the lumen 18 to the opening 20 may be embedded within the wall 21 of the plug.
- conduit 22 can extend through the wall 21 and to travel outside of the wall 21 as shown in Fig. 1 (a).
- the third lumen 19 carries the input or irrigation fluid and this lumen 19 also communicates with the interior 23 of the plug 10. It will be understood that irrigation and aspiration may also be achieved through a single lumen, such as the second lumen 18. So long as the irrigation and aspiration steps are performed sequentially, the third lumen 19 maybe omitted.
- the aspiration port 20 and aspiration lumen ID are larger in diameter than the irrigation inlet and tubing to allow equal flow into and out of the capsule.
- the device is moulded from a material such as silicon or polyurethane such that the device can be rolled into a form allowing it to be passed through the normal cataract corneal incision to the anterior chamber of the eye.
- An insertion device maybe used for this purpose.
- a stiff handle which is parallel with the infusion/aspiration lumens allowing the device to be positioned onto the capsule.
- the handle is removable.
- There may also be a web 24 extending tangentially from the edge of the device to meet the tubing and in the same plane as the tubing which is designed to guide the device through the incision on extraction.
- some embodiments of the invention provide an irrigation port 30 which opens through an interior wall 31 of the plug 10. As shown in this Fig. 2, the irrigation port 30 enters the capsule interior 23 both tangentially and inclined toward the interior capsule surface 11. This orientation provides a swirling motion to the irrigation fluid.
- the plug may take the form of an elongated tube 40.
- the tube 40 terminates in a flange 41 which passes through the rhexis.
- a mechanical seal with the capsule is made by lowering a second close fitting tube 42 over the first tube 40 and thereby gripping or clamping the capsule wall 21 between the second tube 42 and the flange 41.
- This type of plug permits fluids to be introduced and removed directly through the central bore of the tube 40 or through separate lumens which pass through the tube 40.
- an elongated tube 50 and flange 51 maybe secured and sealed against the capsule by an inflatable seal.
- the seal 52 comprises an inflatable ring which surrounds the tube 50 above the flange 51. After the flange 51 is inserted through the rhexis and situated against the capsule wall, the seal 52 is inflated, lightly compressing the capsule between the seal 52 and the flange 51. Pneumatic pressure is introduced and withdrawn from the seal 52 by a conduit or lumen 53 which may extend through the inside diameter of the tube 50, for example as shown in Fig. 4(a).
- a conduit or lumen 53 which may extend through the inside diameter of the tube 50, for example as shown in Fig. 4(a).
- a controller which has the capability to draw a vacuum, preferably at least 500mmHg.
- the vacuum is measured by a pressure or flow sensor such that the infusion of chemicals can be automatically halted if a vacuum leak is detected. Therefore, the controller would accurately measure the vacuum pressure in the seal 15 and immediately halt the flow of irrigation fluid where a pressure drop is detected which could be possibly indicate that chemicals could escape from the sealed capsule.
- a testing process may be employed which calls for a sequence of the fluids to be passed into the capsule by the controller, first the seal and strength of the capsule is tested using a neutral solution, followed by an active chemical chosen to destroy the LECs, and finally by a solution to flush the active chemical from the capsule.
- the chemicals in the capsule can be neutralised before the suction is removed and the device is extracted from the interior chamber of the eye.
- irrigation and aspiration through the lumens or otherwise is controlled by pumps such as peristaltic or syringe pumps.
- the fluid flow controller may be required to prime the infusion and aspiration lines before commencing the procedure.
- the fluid flow is controlled such that the fluid volume in the capsule does not exceed the capsule volume.
- the flow of liquid is derived from the pump or plunger position and confirmed by measuring the pressure on the pump roller or plunger, or by measuring the liquid volume in the aspiration vessel.
- Fig. 5 shows another embodiment of a device according to the invention, indicated generally by the reference numeral 110, for sealing the capsular bag 111 of the lens 112 of a human eye 114 away from the remaining structures of the eye 114.
- the eye 114 is generally composed of a conjunctival 116, a corneal 118, an anterior chamber 20, an iris 122, a posterior chamber 124 and lens zonules 126.
- the device 110 includes a cover assembly 128 and a stem 130.
- the cover assembly 128 has, in use, a substantially spherical- segment, hollow shape and is formed from an inner wall 132 and an outer wall 134 which have a passage 136 therebetween.
- the walls 132 and 134 are maintained spaced apart to keep the passage 136 open by an array of small spacer columns 138.
- the cover assembly 128 is bounded by a peripheral rim 140 which has an annular opening in fluid communication with the passage 136.
- the rim 140 preferably has an external diameter of 5 to 7mm.
- the cover assembly 128 also has an opening 142 in fluid communication with the interior surface of the inner wall 132 and thus with the interior of the cover assembly 128.
- the stem 130 includes an inner channel 144 that terminates at the opening 142 and an outer annular channel 146 in fluid communication with the passage 136 and thus the annular opening 140.
- the inner channel 144 preferably has an internal diameter of about 1 mm.
- the external diameter of the stem 130 is preferably about 3mm.
- FIG. 7 Also shown in Fig. 7 are an inspiration tube or lumen 148 and an aspiration tube or lumen 150, which preferably have an internal diameter of about 0.2 to 0.3mm.
- the purpose and function of the tubes or lumens 148 and 150 will be described in more detail below.
- the cover assembly 128 of the device 110 is, in use, positioned by the surgeon against the lens 112 of the eye 114. A preferred method for positioning the cover assembly will now be described with reference to Figs. 8 to 10.
- Fig. 8 shows the cover assembly 128 and stem 130 contained within a delivery tube 152.
- the cover assembly 128 is rolled into a substantially cylindrical configuration.
- the cover assembly 128 unfurls as a result of its inherent resilience, as indicated by arrows 156, into a substantially spherical segment configuration, as shown in Fig. 9.
- the device 110 can then be operated in the manner shown in Fig. 5, which will be described in more detail below.
- the cover assembly 128 collapses whilst being pulled back into the delivery tube 152, as indicated by the arrows 158.
- the cover assembly 128 may include regions of weakness, such as fold lines 160, to facilitate the collapsing. As the cover assembly 128 is contained within the delivery tube 152 before and after use it is able to be delivered into an anterior and posterior chambers 120 and 124 of the eye 114 by passing the delivery tube 152 through an incision (see Fig. 5) through the coat of the eye 114. It will be appreciated that the use of delivery tubes in positioning surgical instruments in the interior of an eye through a small incision is well known in the art.
- the operation of the device 110 whilst in the position shown in Fig. 5 will now be described.
- the device 110 is positioned with the cover assembly 128 abutting the lens 112. This places the annular opening 140 against the surface of the lens 112.
- a vacuum of, for example about 200 millimetres Hg, is then applied to the outer channel 146 of the stem 130, for example with a manual, syringe-actuated pump.
- the vacuum communicates through the passage 136 and results in the annular opening 140 being suctioned to the surface of the lens 112 to form a substantially fluid tight seal therewith.
- the seal results in a substantially closed cavity being formed between the interior or concave surface of the inner wall 132 of the cover assembly 128 and the lens 112 of the eye 114, thereby sealing the capsular bag 111 away from and the remaining structures of the eye.
- the integrity of the seal can be tested by delivering a sterile dyed fluid into the closed cavity through the inspiration tube 148.
- the dyed fluid is removed via the aspiration tube 150.
- Other fluids can then be delivered to the closed cavity through the inspiration tube 148.
- fluid can be used to flush out epithelial cells and lens fibres.
- the closed (sealed) cavity prevents the fluids from reaching other areas of the eye.
- the inspiration and aspiration tubes 148 and 150 can then be used to flush the cavity and lens clean with saline or other suitable solutions.
- the fluids are injected at a lower positive pressure than the vacuum pressure which forms the seal between the annular opening 140 and the surface of the lens 112, so as to not interrupt the seal. This can cause the capsular bag 111 to enlarge.
- the fluids can be driven through the tubes 148 and 150 with, for example, a manual, syringe actuated, pump or a gravity fed infusion device.
- the cover assembly 128 is preferably manufactured from a non toxic, polymeric material, such as silicon, that is sufficiently flexible to be rolled into the substantially cylindrical configuration and sufficiently rigid to maintain the spherical segment shape in the presence of a positive pressure in the cavity.
- a non toxic, polymeric material such as silicon
- Fig. 11 shows a second embodiment of a device according to the invention, indicated generally by the reference numeral 200.
- the reference numerals used in describing the eye 114 in relation to the first embodiment are again used to indicate like features with respect to the second embodiment.
- the device 200 includes inner and outer concentric conduits 202 and 204 respectively.
- the conduits 202, 204 respectively have an external diameter less then 2mm and 3mm and terminate in substantially flush angled ends 206 and 208.
- the peripheral gap between the ends of the inner and outer conduits 202, 204 defines a rim 210 which functions in a similar manner to the rim 140 of the first embodiment.
- the distal end of the interior of the inner conduit 202 defines an opening 212 which functions in a similar manner to the opening 142 described in relation to the first embodiment.
- the gap between the conduits 202, 204 along their length defines a passage 214 which functions in a similar manner to the passage 136 of the first embodiment and is in fluid communication with the rim 210.
- the operation of the device 200 is similar to that of the device 110 of the first embodiment and will now be described.
- the device 200 is positioned by a surgeon as shown in Fig. 1 by passing the distal end of the device 200 through a small (approximately 2.5mm) incision through the coat of the eye 114.
- the device 200 is then positioned with its distal end abutting the lens 12.
- a vacuum is then applied to the passage 214 which results in the opening 210 being suctioned to the surface of the lens 112 to form a substantially fluid tight seal therewith.
- the seal again results in a substantially closed cavity being formed between the interior of the inner conduit 202 and the lens 112 of the eye 114.
- the integrity of the seal can be tested with dye, as was described in relation to the first embodiment.
- the inspiration and aspiration tubes 148 and 150 (see Figs. 12 and 13) can then be used as was described in relation to the first embodiment.
- the device 210 is preferably manufactured from a non toxic, polymeric material that is sufficiently flexible to be manoeuvrable into the eye and sufficiently rigid to maintain its elongated shape in the presence of negative pressure in the 214 and positive pressure in the interior of the inner conduit 202.
- the device 200 can be used with a smaller incision in the eye than the first embodiment and a smaller incision (preferably less than 2mm or most preferably about 1.5mm) can be used to open the capsular bag 111.
- the advantage provided by the invention is that it allows the lens of the eye to be sealed from other areas of the eye.
- fluids can be delivered to the lens of the eye, for example to irrigate the capsular bag to remove residual lens fibres and epithelial cells, without allowing those fluids to migrate to other areas of the eye where they could harm cells required for the eye to function correctly.
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- Health & Medical Sciences (AREA)
- Ophthalmology & Optometry (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Surgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Prostheses (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
Abstract
Description
Claims
Priority Applications (7)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US10/399,331 US7708723B2 (en) | 2000-11-28 | 2001-11-28 | Device for sealing the capsular bag of an eye and a method for delivering fluid or treatment substances to the lens of an eye |
AU2002218066A AU2002218066B2 (en) | 2000-11-28 | 2001-11-28 | A device for sealing the capsular bag of an eye and a method for delivering fluid or treatment substances to the lens of an eye |
JP2002545613A JP4218872B2 (en) | 2000-11-28 | 2001-11-28 | Device for sealing the capsule of the eye and method for supplying fluid or treatment substance to the lens of the eye |
EP01998290A EP1345561B1 (en) | 2000-11-28 | 2001-11-28 | A device for sealing the capsular bag of an eye |
AU1806602A AU1806602A (en) | 2000-11-28 | 2001-11-28 | A device for sealing the capsular bag of an eye and a method for delivering fluid or treatment substances to the lens of an eye |
AT01998290T ATE448762T1 (en) | 2000-11-28 | 2001-11-28 | DEVICE FOR SEALING THE CAPSULE SACK OF AN EYE |
DE60140566T DE60140566D1 (en) | 2000-11-28 | 2001-11-28 | DEVICE FOR SEALING THE CAPSULE BAG OF AN EYE |
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AUPR1731A AUPR173100A0 (en) | 2000-11-28 | 2000-11-28 | A device for sealing the capsular bag of an eye and a method for delivering fluid or treatment substances to the lens of an eye |
AUPR1731 | 2000-11-28 | ||
AUPR4564 | 2001-04-19 | ||
AUPR4564A AUPR456401A0 (en) | 2001-04-19 | 2001-04-19 | A device for sealing the capsular bag of an eye and a method for delivering fluid or treatment substances to the lens of an eye |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2002043632A1 true WO2002043632A1 (en) | 2002-06-06 |
Family
ID=25646526
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/AU2001/001554 WO2002043632A1 (en) | 2000-11-28 | 2001-11-28 | A device for sealing the capsular bag of an eye and a method for delivering fluid or treatment substances to the lens of an eye |
Country Status (6)
Country | Link |
---|---|
EP (1) | EP1345561B1 (en) |
JP (2) | JP4218872B2 (en) |
AT (1) | ATE448762T1 (en) |
AU (1) | AU1806602A (en) |
DE (1) | DE60140566D1 (en) |
WO (1) | WO2002043632A1 (en) |
Cited By (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2003022191A1 (en) * | 2001-09-11 | 2003-03-20 | Geoffrey James Neilson | Vacuum sealing device |
WO2004039295A1 (en) * | 2002-11-01 | 2004-05-13 | Phaco Treat Ab | Methods and devices usable in eye surgery |
US7717922B2 (en) | 2001-09-11 | 2010-05-18 | Geoffrey James Neilson | Vacuum sealing device |
US8702698B2 (en) | 2008-05-15 | 2014-04-22 | Mynosys Cellular Devices, Inc. | Ophthalmic surgical device for capsulotomy |
US20160361156A1 (en) * | 2004-08-27 | 2016-12-15 | David C. Brown | Intracapsular Pseudophakic Device |
US10070989B2 (en) | 2014-02-03 | 2018-09-11 | Mynosys Cellular Devices, Inc. | Capsulotomy cartridge |
US10206816B2 (en) | 2011-10-21 | 2019-02-19 | Mynosys Cellular Devices, Inc. | Capsulotomy device |
CN111388191A (en) * | 2020-04-24 | 2020-07-10 | 广东省第二人民医院(广东省卫生应急医院) | Device for enucleation of ocular contents and method of operating same |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2008130659A1 (en) | 2007-04-20 | 2008-10-30 | Master Key, Llc | Method and apparatus for identity verification |
WO2015164626A2 (en) * | 2014-04-23 | 2015-10-29 | Seros Medical, Llc | Vacuum-assisted drug delivery device and method |
Citations (3)
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DE3522998A1 (en) * | 1985-06-27 | 1987-01-08 | Patrik Dr Med Gruendler | Device for perforating keratoplasty |
US4796623A (en) * | 1987-07-20 | 1989-01-10 | The Cooper Companies, Inc. | Corneal vacuum trephine system |
WO1997047247A1 (en) * | 1996-06-13 | 1997-12-18 | One Way Ocular Technology, Ltd. | Surgical sealing sleeve |
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US4033349A (en) * | 1976-04-13 | 1977-07-05 | The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration | Corneal seal device |
EP0216952A1 (en) * | 1985-10-04 | 1987-04-08 | Erbe Elektromedizin GmbH. | Device for subretinal drainage |
CA2129124A1 (en) * | 1992-01-29 | 1993-08-05 | Stewart Gregory Smith | Method and apparatus for phaco-emulsification |
US5545179A (en) * | 1995-07-21 | 1996-08-13 | Ethicon Endo-Surgery, Inc. | Endoscopic access assembly |
US5669923A (en) * | 1996-01-24 | 1997-09-23 | Gordon; Mark G. | Anterior capsulotomy device and procedure |
JPH11137592A (en) * | 1997-11-11 | 1999-05-25 | Menicon Co Ltd | Plug for anterior capsule of lens |
IL124817A (en) * | 1998-06-08 | 2001-12-23 | Front Door Ocular Technology L | Surgical sealing sleeve |
JP2000107208A (en) * | 1998-10-01 | 2000-04-18 | Aizo Yamauchi | Pore sealing body and contour rope sealing method for vital organ |
EP1154736B1 (en) * | 1999-02-22 | 2004-12-29 | University Of Miami | Minicapsulorhexis valve |
-
2001
- 2001-11-28 EP EP01998290A patent/EP1345561B1/en not_active Expired - Lifetime
- 2001-11-28 AU AU1806602A patent/AU1806602A/en active Pending
- 2001-11-28 JP JP2002545613A patent/JP4218872B2/en not_active Expired - Fee Related
- 2001-11-28 WO PCT/AU2001/001554 patent/WO2002043632A1/en active Application Filing
- 2001-11-28 DE DE60140566T patent/DE60140566D1/en not_active Expired - Lifetime
- 2001-11-28 AT AT01998290T patent/ATE448762T1/en not_active IP Right Cessation
-
2008
- 2008-01-31 JP JP2008021551A patent/JP2008155038A/en active Pending
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
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DE3522998A1 (en) * | 1985-06-27 | 1987-01-08 | Patrik Dr Med Gruendler | Device for perforating keratoplasty |
US4796623A (en) * | 1987-07-20 | 1989-01-10 | The Cooper Companies, Inc. | Corneal vacuum trephine system |
WO1997047247A1 (en) * | 1996-06-13 | 1997-12-18 | One Way Ocular Technology, Ltd. | Surgical sealing sleeve |
Cited By (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2003022191A1 (en) * | 2001-09-11 | 2003-03-20 | Geoffrey James Neilson | Vacuum sealing device |
EP1435886A1 (en) * | 2001-09-11 | 2004-07-14 | Geoffrey James Neilson | Vacuum sealing device |
EP1435886A4 (en) * | 2001-09-11 | 2006-01-04 | Geoffrey James Neilson | Vacuum sealing device |
US7717922B2 (en) | 2001-09-11 | 2010-05-18 | Geoffrey James Neilson | Vacuum sealing device |
WO2004039295A1 (en) * | 2002-11-01 | 2004-05-13 | Phaco Treat Ab | Methods and devices usable in eye surgery |
US20160361156A1 (en) * | 2004-08-27 | 2016-12-15 | David C. Brown | Intracapsular Pseudophakic Device |
US9254224B2 (en) | 2008-05-15 | 2016-02-09 | Mynosys Cellular Devices, Inc. | Ophthalmic surgical device for capsulotomy |
US9271868B2 (en) | 2008-05-15 | 2016-03-01 | Mynosys Cellular Devices, Inc. | Ophthalmic surgical device for capsulotomy |
US8702698B2 (en) | 2008-05-15 | 2014-04-22 | Mynosys Cellular Devices, Inc. | Ophthalmic surgical device for capsulotomy |
US10278760B2 (en) | 2008-05-15 | 2019-05-07 | Mynosys Cellular Devices, Inc. | Ophthalmic surgical device for capsulotomy |
US11406439B2 (en) | 2008-05-15 | 2022-08-09 | Centricity Vision, Inc. | Ophthalmic surgical device for capsulotomy |
US10206816B2 (en) | 2011-10-21 | 2019-02-19 | Mynosys Cellular Devices, Inc. | Capsulotomy device |
US10736777B2 (en) | 2011-10-21 | 2020-08-11 | Centricity Vision, Inc. | Capsulotomy device |
US11426308B2 (en) | 2011-10-21 | 2022-08-30 | Centricity Vision, Inc. | Capsulotomy device |
US12004998B2 (en) | 2011-10-21 | 2024-06-11 | Centricity Vision, Inc. | Capsulotomy device |
US10070989B2 (en) | 2014-02-03 | 2018-09-11 | Mynosys Cellular Devices, Inc. | Capsulotomy cartridge |
CN111388191A (en) * | 2020-04-24 | 2020-07-10 | 广东省第二人民医院(广东省卫生应急医院) | Device for enucleation of ocular contents and method of operating same |
Also Published As
Publication number | Publication date |
---|---|
ATE448762T1 (en) | 2009-12-15 |
JP2004513756A (en) | 2004-05-13 |
EP1345561B1 (en) | 2009-11-18 |
EP1345561A1 (en) | 2003-09-24 |
AU1806602A (en) | 2002-06-11 |
DE60140566D1 (en) | 2009-12-31 |
EP1345561A4 (en) | 2006-12-13 |
JP4218872B2 (en) | 2009-02-04 |
JP2008155038A (en) | 2008-07-10 |
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