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US3185626A - Tablet coating method - Google Patents

Tablet coating method Download PDF

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Publication number
US3185626A
US3185626A US263100A US26310063A US3185626A US 3185626 A US3185626 A US 3185626A US 263100 A US263100 A US 263100A US 26310063 A US26310063 A US 26310063A US 3185626 A US3185626 A US 3185626A
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Prior art keywords
tablets
tablet
syrup
coating
sucrose
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Expired - Lifetime
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US263100A
Inventor
Claude W Baker
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STWB Inc
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Sterling Drug Inc
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Priority to US263100A priority Critical patent/US3185626A/en
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating

Definitions

  • This invention relates to tablets and other individual dosage forms. More particularly the invention is concerned with an economical, time-saving process for sugar coating core tablets.
  • Tablet coating is an old art in which traditional methods have remained essentially unchanged although in recent years some steps have been made toward reducing the tedious and time-consuming operation.
  • a tablet or compressed pellet is sized with a water repellent resin such as shellac or zein and the resultant tablet 0r pellet is then subcoated with several coats of a material such as gelatin or acacia along with subcoating powders designed for dusting the subcoats.
  • the subcoating operation although time consuming and expensive has been considered necessary in order to round and shape the tablet preparatory to applying a sugar coating with or without added coloring.
  • the film coating procedures suffer from a number of disadvantages which in certain instances outweigh the time-saving advantages.
  • the filmforming materials being organic in nature require the use of organic solvents, e.g., alcohol, acetone, ether etc., which are flammable and toxic. It is therefore necessary to carry out the process in explosion-proof equipment with provision for adequate ventilation and exhaust.
  • core tablets that is, tablets which may be sealed, sized or enteric coated but not rounded, are sugar coated in one-quarter to one-third the time required by any previously known method. Utilization of the compositions and process of the invention greatly reduces the operating time by eliminating completely subcoats and smoothing coats hitherto believed necessary.
  • a color either water-soluble or waterinsoluble, can be incorporated at any stage to give a stable, pharmaceutically elegant finished tablet for which the color is reproducible from batch to batch or operator to operator. There is no necessity for subcoating the rough core tablet or applying smoothing coats yet the finished tablet has stability upon aging, resistance to cracking during sudden temperature changes and a pleasing appearance 7O comparable with tablets made by conventional procedures.
  • compositions useful in the process of the invention are comprised of an adhesive aqueous suspending medium such as a gelatin solution or preferably a syrup solution and an opaque non-toxic, pharmaceutically acceptable water insoluble pigment as for example titanium dioxide, iron oxide, barium sulfate and calcium carbonate, and if desired a non-toxic dye of either the water-soluble or water-insoluble type.
  • an adhesive aqueous suspending medium such as a gelatin solution or preferably a syrup solution
  • an opaque non-toxic, pharmaceutically acceptable water insoluble pigment as for example titanium dioxide, iron oxide, barium sulfate and calcium carbonate, and if desired a non-toxic dye of either the water-soluble or water-insoluble type.
  • the aqueous suspending medium is preferably a syrup solution, e.g., an aqueous sugar solution such as an aqueous solution of glucose, lactose, maltose or sucrose.
  • a syrup solution e.g., an aqueous sugar solution such as an aqueous solution of glucose, lactose, maltose or sucrose.
  • the preferred syrup or sugar solution is a sucrose solution although other sugar derivatives such as mannitol and sorbitol can be used.
  • compositions useful in carrying out the improved process can, if desired, contain coloring materials which are any of the non-toxic dyes, lakes and pigments which have been certified for use in the food, drug and cosmetic industries.
  • coloring materials which are any of the non-toxic dyes, lakes and pigments which have been certified for use in the food, drug and cosmetic industries.
  • water-soluble dyes as illustrated by PD & C Yellow No. 5
  • water-insoluble dyes and lakes as illustrated by .D & C Green No. 5
  • pigments as illustrated by yellow, brown, red and black iron oxides, titanium dioxide and barium sulfate are suitable as colorants.
  • the method of coating core tablets in accordance with the invention comprises forming the syrup or sugar solution in which is suspended the opacifying material by the use of suitable mixing equipment. The suspension is then added to core tablets in a rotating coating pan and the appropriate number of coats applied with air drying after each coat. At any stage colors of the type described above can be added if desired by adding the appropiate color to the syrup and applying the number of coats necessary to give the desired coloring.
  • Example 1 Coating suspensions incorporating various dyes were prepared as follows:
  • Titanium dioxide N.F. 7.20
  • Titanium dioxide N.F. 7.20
  • Titanium dioxide N.F. 7.20
  • Titanium dioxide N.F. 7.20
  • Titanium dioxide N.F. 7.20
  • the above suspension was applied to a run of sized, unrounded oxypertine tablets rotating in a coating pan.
  • a total of 40 mg. per tablet of the coating composition was applied in about two and one-half hours to give a white sugar coated tablet equal in quality to oxypertine tablets coated in the conventional in five hours.
  • a suspension of the above ingredients was applied to a run of size, unrounded pancreatin-containing digestant tablets sold under the trademark Doxegest rotating in a coating pan.
  • Application of the coating composition required about two and one-half hours and the resultant brown tablet was comparable to subcoated Doxegest tablets and required about one-third the time.
  • a suspension of the above ingredients was applied to a run of sized, unrounded cold tablets containing phenylephrine sold under the trademark Neosynephrine, acetyl p-aminophenol and vitamin C rotating in a coating pan.
  • a total of 125 mg. per tablet was applied in about two and one-half hours.
  • the yellow tablet thus obtained was equal in quality to sized, unrounded cold tablets coated in the conventional manner in six hours.
  • the pigment is selected from the group consisting of titanium dioxide, calicum carbonate, barium sulfate and iron oxide.
  • aqueous suspending medium comprises a sucrose solution containing titanium dioxide and a colorant

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  • Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
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Description

United States Patent 3,185,626 TABLET CGATING METHOD Claude W. Baker, Albany, N.Y., assigner to Sterling Drug Inc, New York, N.Y., a corporation of Delaware No Drawing. Filed Mar. 6, 1963, Ser. No. 263,100
5 Claims. (Cl. 167--82) This invention relates to tablets and other individual dosage forms. More particularly the invention is concerned with an economical, time-saving process for sugar coating core tablets.
Tablet coating is an old art in which traditional methods have remained essentially unchanged although in recent years some steps have been made toward reducing the tedious and time-consuming operation. Thus, a tablet or compressed pellet is sized with a water repellent resin such as shellac or zein and the resultant tablet 0r pellet is then subcoated with several coats of a material such as gelatin or acacia along with subcoating powders designed for dusting the subcoats. The subcoating operation although time consuming and expensive has been considered necessary in order to round and shape the tablet preparatory to applying a sugar coating with or without added coloring. After further finishing and polishing there is obtained a pharmaceutically elegant tablet but the inordinate amount of time required in the application and drying of the numerous coats including subcoating, color coating and smoothing coat maks the production of such tablets quite expensive.
In comparatively recent times various film coating procedures have been introduced and these methods have materailly reduced the time required to prepare a finished tablet. However, the film coating procedures suffer from a number of disadvantages which in certain instances outweigh the time-saving advantages. For example, the filmforming materials being organic in nature require the use of organic solvents, e.g., alcohol, acetone, ether etc., which are flammable and toxic. It is therefore necessary to carry out the process in explosion-proof equipment with provision for adequate ventilation and exhaust.
Further complications to the well-known tabletting procedures are introduced when it is desired to color the tablet for purposes of distinctiveness or identification. For many years only dyes of the soluble type were used and this necessarily limited the number and range of colors that could be used. In recent times insoluble dyes or lakes have been incorporated into coloring compositions by the use of surfactants to maintain the dyes or lakes in suspension and more recently it has been found that the surfactant was unnecessary. These improvements materially reduced the operating time for coloring solids but the time-consuming subcoating of the tablets was still carried out.
According to the present invention core tablets, that is, tablets which may be sealed, sized or enteric coated but not rounded, are sugar coated in one-quarter to one-third the time required by any previously known method. Utilization of the compositions and process of the invention greatly reduces the operating time by eliminating completely subcoats and smoothing coats hitherto believed necessary.
Additionally, a color, either water-soluble or waterinsoluble, can be incorporated at any stage to give a stable, pharmaceutically elegant finished tablet for which the color is reproducible from batch to batch or operator to operator. There is no necessity for subcoating the rough core tablet or applying smoothing coats yet the finished tablet has stability upon aging, resistance to cracking during sudden temperature changes and a pleasing appearance 7O comparable with tablets made by conventional procedures.
Patented May 25, 1965 The compositions useful in the process of the invention are comprised of an adhesive aqueous suspending medium such as a gelatin solution or preferably a syrup solution and an opaque non-toxic, pharmaceutically acceptable water insoluble pigment as for example titanium dioxide, iron oxide, barium sulfate and calcium carbonate, and if desired a non-toxic dye of either the water-soluble or water-insoluble type.
The aqueous suspending medium is preferably a syrup solution, e.g., an aqueous sugar solution such as an aqueous solution of glucose, lactose, maltose or sucrose. The preferred syrup or sugar solution is a sucrose solution although other sugar derivatives such as mannitol and sorbitol can be used.
The compositions useful in carrying out the improved process can, if desired, contain coloring materials which are any of the non-toxic dyes, lakes and pigments which have been certified for use in the food, drug and cosmetic industries. For example, water-soluble dyes as illustrated by PD & C Yellow No. 5, water-insoluble dyes and lakes as illustrated by .D & C Green No. 5 and pigments as illustrated by yellow, brown, red and black iron oxides, titanium dioxide and barium sulfate are suitable as colorants.
The method of coating core tablets in accordance with the invention comprises forming the syrup or sugar solution in which is suspended the opacifying material by the use of suitable mixing equipment. The suspension is then added to core tablets in a rotating coating pan and the appropriate number of coats applied with air drying after each coat. At any stage colors of the type described above can be added if desired by adding the appropiate color to the syrup and applying the number of coats necessary to give the desired coloring.
The following examples will further illustrate the invention, without however limiting the latter thereto.
Example 1 Coating suspensions incorporating various dyes were prepared as follows:
(A) Grams FD & C Yellow No. 5 0.20
Titanium dioxide, N.F. 7.20
Sucrose (as 70% syrup) 360.00
PD 8.: C Blue No. 1 0.07
Titanium dioxide, N.F. 7.20
Sucrose (as 70% syrup) 360.00
PD & C Yellow No. 6 0.22
Titanium dioxide, N.F. 7.20
Sucrose (as 70% syrup) 360.00
FD & C Red No. 4 0.25
Titanium dioxide, N.F. 7.20
Sucrose (as 70% syrup) 360.00
Mapico Black 0.72
Titanium dioxide, N.F. 7.20
Sucrose (as 70% syrup)- 360.00
Mapico Black 0.36
Brown iron oxide 7.20
Sucrose (as 70% syrup) 360.00
The dyes and pigments were suspended in the syrup and thoroughly mixed. Each of the coloring compositions was added to sized unrounded placebo tablets in a rotating pan until the tablets were evenly covered. The result- Example 2 Grams Titanium dioxide, NF. 14.0 Sucrose (as 70% syrup) 800.0
The above suspension was applied to a run of sized, unrounded oxypertine tablets rotating in a coating pan. A total of 40 mg. per tablet of the coating composition Was applied in about two and one-half hours to give a white sugar coated tablet equal in quality to oxypertine tablets coated in the conventional in five hours.
Example 3 Kilograms Brown iron oxide 0.232
Vanillin 0.004 Sucrose (as 70% syrup) 9.200
A suspension of the above ingredients was applied to a run of size, unrounded pancreatin-containing digestant tablets sold under the trademark Doxegest rotating in a coating pan. Application of the coating composition required about two and one-half hours and the resultant brown tablet was comparable to subcoated Doxegest tablets and required about one-third the time.
Example 4 Grams Titanium dioxide, NF. 2.80 FD & C Yellow No. 5 .062
Sucrost (as 70% syrup) 250.00
A suspension of the above ingredients was applied to a run of sized, unrounded cold tablets containing phenylephrine sold under the trademark Neosynephrine, acetyl p-aminophenol and vitamin C rotating in a coating pan. A total of 125 mg. per tablet was applied in about two and one-half hours. The yellow tablet thus obtained was equal in quality to sized, unrounded cold tablets coated in the conventional manner in six hours.
I claim:
1. .A method of coating tablets which comprises repeatedly adding portions of an aqueous suspending medium containing a non-toxic pharmaceutically acceptable pigment to sized, unround tablets rotating in a coating pan.
2. The method of claim 1 in which the pigment is selected from the group consisting of titanium dioxide, calicum carbonate, barium sulfate and iron oxide.
3. The method of claim 1 in which the aqueous suspending medium is a syrup solution.
4. The method of claim 1 in which a member of the group consisting of water-soluble and water-insoluble dyes is incorporated in the aqueous suspending medium.
5. The method according to claim 1 in which the aqueous suspending medium comprises a sucrose solution containing titanium dioxide and a colorant, and
.drying the finished tablets.
References Cited by the Examiner UNITED STATES PATENTS 9/62 Ralf 16782 9/64 Jeffries 16782

Claims (1)

1. A METHOD OF COATING TABLETS WHICH COMPRISES REPEATEDLY ADDING PORTIONS OF AN AQUEOUS SUSPENDING MEDIUM CONTAINING A NON-TOXIC PHARMACEUTICALLY ACCEPTABLE PIGMENT TO SIZED, UNROUND TABLETS ROTATING IN A COATING PAN.
US263100A 1963-03-06 1963-03-06 Tablet coating method Expired - Lifetime US3185626A (en)

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Cited By (50)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3361631A (en) * 1963-09-30 1968-01-02 Sandoz Ag Method of sugar coating pharmaceutical tablets
US3421920A (en) * 1965-05-25 1969-01-14 Ciba Geigy Corp Tablet coating containing a linear poly-1,3-beta-glucoside
US4146653A (en) * 1976-08-11 1979-03-27 J. Pfrimmer & Co. Process of manufacturing dragees
WO1981001100A1 (en) * 1979-10-17 1981-04-30 Roquette Freres Process for hard coating with sorbitol and products obtained thereby
FR2467597A1 (en) * 1979-10-17 1981-04-30 Roquette Freres HARD DRAGEIFICATION PROCESS WITH SORBITOL AND PRODUCTS THUS OBTAINED
US4421738A (en) * 1979-07-31 1983-12-20 Eisai Co., Ltd. Sugar-coated tablet containing fat-soluble pharmaceutical material
US4693750A (en) * 1985-02-22 1987-09-15 Meggle Milchindustrie Gmbh & Co. Kg. Direct tabletting agent
US4820524A (en) * 1987-02-20 1989-04-11 Mcneilab, Inc. Gelatin coated caplets and process for making same
US4867983A (en) * 1987-02-20 1989-09-19 Mcneilab, Inc. Method for double dipping gelating coated caplets
US4965089A (en) * 1989-04-10 1990-10-23 Sauter Manufacturing Corp. Method and apparatus for the gelatin coating of caplets
US4966771A (en) * 1987-02-20 1990-10-30 Mcneilab, Inc. Gelatin coated caplets and process for making same
US4990358A (en) * 1987-02-20 1991-02-05 Mcneilab, Inc. Method for double dipping gelatin coated caplets
US5198227A (en) * 1990-01-22 1993-03-30 Mcneil-Ppc, Inc. Dual subcoated simulated capsule medicament
US5512314A (en) * 1993-02-24 1996-04-30 Warner-Jenkinson Company Dye compositions and methods for film coating tablets and the like
US5658589A (en) * 1989-04-28 1997-08-19 Mcneil-Ppc, Inc. Subcoated simulated capsule-like medicament
US6080426A (en) * 1994-12-16 2000-06-27 Warner-Lamberg Company Process for encapsulation of caplets in a capsule and solid dosage forms obtainable by such process
US6113945A (en) * 1996-02-26 2000-09-05 L. Perrigo Company Multi-colored medicament
WO2001037816A2 (en) * 1999-11-23 2001-05-31 Biochemie Gesellschaft M.B.H. Coating of tablet cores
US6245350B1 (en) 1994-12-16 2001-06-12 Warner-Lambert Company Process for encapsulation of caplets in a capsule and solid dosage forms obtainable by such process
US20030108607A1 (en) * 2001-09-28 2003-06-12 Szymczak Christopher E. Film forming compositions containing sucralose
US20030219484A1 (en) * 2001-09-28 2003-11-27 Sowden Harry S. Immediate release dosage form comprising shell having openings therein
US20040022755A1 (en) * 2002-08-02 2004-02-05 Satish Kamath Polyacrylic film forming compositions
WO2004028508A1 (en) 2002-09-28 2004-04-08 Mcneil-Ppc, Inc. Modified release dosage forms with two cores and an opening
US20050008696A1 (en) * 2001-09-28 2005-01-13 Sowden Harry S. Systems, methods and apparatuses for manufacturing dosage forms
US20050152970A1 (en) * 2004-01-13 2005-07-14 Rinker Roger A. Rapidly disintegrating gelatinous coated tablets
EP1602363A1 (en) 2004-06-04 2005-12-07 McNeil-PPC, Inc. Immediate release dosage form comprising shell having openings therein
US20060062811A1 (en) * 2004-09-21 2006-03-23 Szymczak Christopher E Medicinal cooling emulsions
US20060118991A1 (en) * 2004-12-07 2006-06-08 Sowden Harry S System and process for providing at least one opening in dosage forms
US20060121145A1 (en) * 2004-12-07 2006-06-08 Sowden Harry S System and process for providing at least one opening in dosage forms
US20060233881A1 (en) * 2005-04-15 2006-10-19 Sowden Harry S Modified release dosage form
US20060233882A1 (en) * 2005-04-15 2006-10-19 Sowden Harry S Osmotic dosage form
US20070128268A1 (en) * 2005-12-07 2007-06-07 Herwig Jennewein Pharmaceutical compositions comprising an antibiotic
US20070231389A1 (en) * 2006-03-28 2007-10-04 Bunick Frank J Non-homogenous dosage form coatings
US20070259098A1 (en) * 2001-05-15 2007-11-08 Cynthia Gulian Method for dip coating dosage forms
US20080031927A1 (en) * 2006-07-11 2008-02-07 Catani Steven J Solid oral dosage vitamin and mineral compositions
US20080069880A1 (en) * 2002-05-15 2008-03-20 Bunick Frank J Enrobed core
US20080075766A1 (en) * 2006-09-25 2008-03-27 Shun-Por Li Multi-core dosage form having transparent outer coating
US20080118571A1 (en) * 2006-11-21 2008-05-22 Der-Yang Lee Modified release analgesic suspensions
US20080311201A1 (en) * 2007-06-12 2008-12-18 Lee Der-Yang Modified release solid or semi-solid dosage forms
US20080317677A1 (en) * 2007-06-22 2008-12-25 Szymczak Christopher E Laser Marked Dosage Forms
US20080317678A1 (en) * 2007-06-22 2008-12-25 Szymczak Christopher E Laser Marked Dosage Forms
US20090074866A1 (en) * 2007-09-17 2009-03-19 Jen-Chi Chen Dip coated compositions containing copolymer of polyvinyl alcohol and polyethylene glycol and a gum
US20090092739A1 (en) * 2001-05-15 2009-04-09 Cynthia Gulian Method of dip-coating dosage forms
US20090162435A1 (en) * 2007-12-21 2009-06-25 Bunick Frank J Manufacture of tablet
US20090208574A1 (en) * 2008-02-19 2009-08-20 Jen-Chi Chen Dip coated compositions containing a starch having a high amylose content
US20090324716A1 (en) * 2008-06-26 2009-12-31 Robert Shen Coated Particles Containing Pharmaceutically Active Agents
US20100062061A1 (en) * 2008-09-05 2010-03-11 Kenneth Day Method For Making Cetirizine Tablets
US7838026B2 (en) 2001-09-28 2010-11-23 Mcneil-Ppc, Inc. Burst-release polymer composition and dosage forms comprising the same
US8067029B2 (en) 2004-01-13 2011-11-29 Mcneil-Ppc, Inc. Rapidly disintegrating gelatinous coated tablets
EP2385766B1 (en) 2009-01-07 2018-04-18 Chr. Hansen Natural Colors A/S A composition comprising calcium carbonate as a white pigment

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US3054724A (en) * 1960-05-12 1962-09-18 Smith Kline French Lab Coloring discrete solids and compositions therefor
US3149038A (en) * 1961-09-05 1964-09-15 Dow Chemical Co Thin film coating for tablets and the like and method of coating

Patent Citations (2)

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US3054724A (en) * 1960-05-12 1962-09-18 Smith Kline French Lab Coloring discrete solids and compositions therefor
US3149038A (en) * 1961-09-05 1964-09-15 Dow Chemical Co Thin film coating for tablets and the like and method of coating

Cited By (102)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3361631A (en) * 1963-09-30 1968-01-02 Sandoz Ag Method of sugar coating pharmaceutical tablets
US3421920A (en) * 1965-05-25 1969-01-14 Ciba Geigy Corp Tablet coating containing a linear poly-1,3-beta-glucoside
US4146653A (en) * 1976-08-11 1979-03-27 J. Pfrimmer & Co. Process of manufacturing dragees
US4421738A (en) * 1979-07-31 1983-12-20 Eisai Co., Ltd. Sugar-coated tablet containing fat-soluble pharmaceutical material
US4423086A (en) * 1979-10-17 1983-12-27 Roquette Freres Process for hard coating with sorbitol and products obtained thereby
FR2467597A1 (en) * 1979-10-17 1981-04-30 Roquette Freres HARD DRAGEIFICATION PROCESS WITH SORBITOL AND PRODUCTS THUS OBTAINED
WO1981001100A1 (en) * 1979-10-17 1981-04-30 Roquette Freres Process for hard coating with sorbitol and products obtained thereby
US4693750A (en) * 1985-02-22 1987-09-15 Meggle Milchindustrie Gmbh & Co. Kg. Direct tabletting agent
US4820524A (en) * 1987-02-20 1989-04-11 Mcneilab, Inc. Gelatin coated caplets and process for making same
US4867983A (en) * 1987-02-20 1989-09-19 Mcneilab, Inc. Method for double dipping gelating coated caplets
US5314537A (en) * 1987-02-20 1994-05-24 Mcneilab, Inc. Gelatin coated caplets and process for making same
US4966771A (en) * 1987-02-20 1990-10-30 Mcneilab, Inc. Gelatin coated caplets and process for making same
US4990358A (en) * 1987-02-20 1991-02-05 Mcneilab, Inc. Method for double dipping gelatin coated caplets
AU620829B2 (en) * 1987-12-04 1992-02-27 Mcneil Consumer Products Company Method for double dipping gelatin coated caplets
US4965089A (en) * 1989-04-10 1990-10-23 Sauter Manufacturing Corp. Method and apparatus for the gelatin coating of caplets
US7087242B2 (en) 1989-04-28 2006-08-08 Mcneil-Ppc, Inc. Subcoated simulated capsule-like medicament
US6120801A (en) * 1989-04-28 2000-09-19 Mcneil-Ppc, Inc. Subcoated simulated capsule-like medicament
US20020031546A1 (en) * 1989-04-28 2002-03-14 Parekh Kishor B. Subcoated simulated capsule-like medicament
US5658589A (en) * 1989-04-28 1997-08-19 Mcneil-Ppc, Inc. Subcoated simulated capsule-like medicament
US5770225A (en) * 1989-04-28 1998-06-23 Mcneil-Ppc, Inc. Process of preparing a subcoated simulated capsule-like medicament
US5916592A (en) * 1989-04-28 1999-06-29 Mcneil-Ppc, Inc. Subcoated simulated capsule-like medicament
US6326026B1 (en) 1989-04-28 2001-12-04 Mcneil-Ppc, Inc. Subcoated simulated capsule-like medicament
US6214380B1 (en) 1989-04-28 2001-04-10 Mcneil-Ppc, Inc. Subcoated simulated capsule-like medicament
US5198227A (en) * 1990-01-22 1993-03-30 Mcneil-Ppc, Inc. Dual subcoated simulated capsule medicament
US5296233A (en) * 1990-01-22 1994-03-22 Mcneil-Ppc, Inc. Dual subcoated simulated capsule-like medicament
US5512314A (en) * 1993-02-24 1996-04-30 Warner-Jenkinson Company Dye compositions and methods for film coating tablets and the like
US6245350B1 (en) 1994-12-16 2001-06-12 Warner-Lambert Company Process for encapsulation of caplets in a capsule and solid dosage forms obtainable by such process
US6080426A (en) * 1994-12-16 2000-06-27 Warner-Lamberg Company Process for encapsulation of caplets in a capsule and solid dosage forms obtainable by such process
US6113945A (en) * 1996-02-26 2000-09-05 L. Perrigo Company Multi-colored medicament
US8652517B2 (en) * 1999-11-23 2014-02-18 Sandoz Gmbh Coating of tablet cores
WO2001037816A2 (en) * 1999-11-23 2001-05-31 Biochemie Gesellschaft M.B.H. Coating of tablet cores
WO2001037816A3 (en) * 1999-11-23 2001-11-29 Biochemie Gmbh Coating of tablet cores
US20060034917A1 (en) * 1999-11-23 2006-02-16 Reinhard Entner Coating of tablet cores
US20090092739A1 (en) * 2001-05-15 2009-04-09 Cynthia Gulian Method of dip-coating dosage forms
US7785650B2 (en) 2001-05-15 2010-08-31 Mcneil-Ppc, Inc. Method for dip coating dosage forms
US20070259098A1 (en) * 2001-05-15 2007-11-08 Cynthia Gulian Method for dip coating dosage forms
US20050266084A1 (en) * 2001-09-28 2005-12-01 Shun-Por Li Modified release dosage forms
US20030219484A1 (en) * 2001-09-28 2003-11-27 Sowden Harry S. Immediate release dosage form comprising shell having openings therein
US20050019407A1 (en) * 2001-09-28 2005-01-27 Sowden Harry S. Composite dosage forms
US20040213849A1 (en) * 2001-09-28 2004-10-28 Sowden Harry S. Modified release dosage forms
US8673190B2 (en) 2001-09-28 2014-03-18 Mcneil-Ppc, Inc. Method for manufacturing dosage forms
US8545887B2 (en) 2001-09-28 2013-10-01 Mcneil-Ppc, Inc. Modified release dosage forms
US7416738B2 (en) 2001-09-28 2008-08-26 Mcneil-Ppc, Inc. Modified release dosage form
US8309118B2 (en) 2001-09-28 2012-11-13 Mcneil-Ppc, Inc. Film forming compositions containing sucralose
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