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UA101668C2 - Производные азакарболинов, способ их получения и применения в терапии - Google Patents

Производные азакарболинов, способ их получения и применения в терапии

Info

Publication number
UA101668C2
UA101668C2 UAA201100324A UAA201100324A UA101668C2 UA 101668 C2 UA101668 C2 UA 101668C2 UA A201100324 A UAA201100324 A UA A201100324A UA A201100324 A UAA201100324 A UA A201100324A UA 101668 C2 UA101668 C2 UA 101668C2
Authority
UA
Ukraine
Prior art keywords
optionally substituted
branched
heterocycloalkyl
linear
azacarbolines
Prior art date
Application number
UAA201100324A
Other languages
English (en)
Ukrainian (uk)
Inventor
Кристофер Арендт
Дидье Бабен
Оливье Бедель
Тьерри Гуйон
Михаил Левит
Серж Миньяни
Нейл Муркрофт
Давид Папен
Жунхуа Ли
Original Assignee
Санофи-Авентис
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Санофи-Авентис filed Critical Санофи-Авентис
Publication of UA101668C2 publication Critical patent/UA101668C2/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/73—Unsubstituted amino or imino radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyridine Compounds (AREA)

Abstract

Представленное изобретение касается новых азакарболинов формулы (I),в которой: R3, R4 независимо друг от друга означают Н; галоген; CF; замещенный окси; необязательно замещенный алкокси; необязательно замещенный амино; замещенный карбонил; необязательно замещенный карбоксил; необязательно замещенный амид; серу, такую как сульфиды, сульфоксиды или сульфоны, необязательно замещенные; С-С-алкил, линейный, разветвленный или циклический, который необязательно содержит гетероатом, необязательно замещенный; С-С-алкенил, линейный, разветвленный или циклический, необязательно замещенный; С-С-алкинил, линейный или разветвленный, необязательно замещенный; арил или гетероарил, необязательно замещенный; гетероциклоа�
UAA201100324A 2008-06-12 2009-06-11 Производные азакарболинов, способ их получения и применения в терапии UA101668C2 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0803262 2008-06-12
PCT/FR2009/051100 WO2009150381A2 (fr) 2008-06-12 2009-06-11 Derives d'azacarbolines, leur preparation et leur utilisation therapeutique

Publications (1)

Publication Number Publication Date
UA101668C2 true UA101668C2 (ru) 2013-04-25

Family

ID=40445526

Family Applications (1)

Application Number Title Priority Date Filing Date
UAA201100324A UA101668C2 (ru) 2008-06-12 2009-06-11 Производные азакарболинов, способ их получения и применения в терапии

Country Status (26)

Country Link
US (1) US20110178053A1 (ru)
EP (1) EP2303882A2 (ru)
JP (1) JP2011522867A (ru)
KR (1) KR20110016998A (ru)
CN (1) CN102124007A (ru)
AR (1) AR072084A1 (ru)
AU (1) AU2009259114B2 (ru)
BR (1) BRPI0915204A2 (ru)
CA (1) CA2725093A1 (ru)
CO (1) CO6280536A2 (ru)
CR (1) CR11814A (ru)
DO (1) DOP2010000366A (ru)
EA (1) EA018945B1 (ru)
EC (1) ECSP10010670A (ru)
IL (1) IL209840A0 (ru)
MA (1) MA32460B1 (ru)
MX (1) MX2010013699A (ru)
NI (1) NI201000210A (ru)
NZ (1) NZ589839A (ru)
PE (1) PE20110122A1 (ru)
SV (1) SV2010003754A (ru)
TW (1) TW201002711A (ru)
UA (1) UA101668C2 (ru)
UY (1) UY31895A (ru)
WO (1) WO2009150381A2 (ru)
ZA (1) ZA201008387B (ru)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2725754C (en) * 2008-06-11 2017-05-23 Hazel Joan Dyke Diazacarbazoles and methods of use
NZ589532A (en) 2008-06-12 2012-02-24 Janssen Pharmaceutica Nv Diamino-pyridine, pyrimidine, and pyridazine modulators of the histamine H4 receptor
TW201035097A (en) * 2009-03-24 2010-10-01 Sanofi Aventis 9H-pyrrolo[2,3-b:5,4-c']dipyridine azacarboline derivatives, preparation and therapeutic use thereof
FR2950891B1 (fr) * 2009-10-06 2012-11-09 Sanofi Aventis Derives d'azacarbolines 9h-pyrrolo[2,3-b:5,4-c']dipyridine, leur preparation et leur utilisation therapeutique
FR2953838B1 (fr) * 2009-12-10 2012-02-24 Sanofi Aventis Derives de 9h-beta-carboline (ou 9h-pyridino[3,4-b]indole) trisubstitues, leur preparation et leur utilisation therapeutique
US20110183938A1 (en) * 2009-12-16 2011-07-28 Genentech, Inc. 1,7-diazacarbazoles and methods of use
WO2014164596A1 (en) * 2013-03-11 2014-10-09 The Regents Of The University Of Michigan Bet bromodomain inhibitors and therapeutic methods using the same
KR101652577B1 (ko) * 2013-04-19 2016-08-30 영남대학교 산학협력단 아미도피리딘올 유도체 또는 이의 약제학적 허용가능한 염 및 이를 유효성분으로 함유하는 혈관신생으로 인한 질환의 예방 또는 치료용 약학조성물
CN103408573B (zh) * 2013-07-12 2015-12-23 上海工程技术大学 硼酸衍生物及其制备方法和应用
WO2018137655A1 (zh) * 2017-01-25 2018-08-02 江苏豪森药业集团有限公司 吡咯并吡啶类n-氧化衍生物及其制备方法和应用
EP3666770A4 (en) * 2017-08-07 2021-04-07 Joint Stock Company "Biocad" NEW HETEROCYCLIC COMPOUNDS AS CDK8 / 19 INHIBITORS
CN112566912A (zh) 2018-05-04 2021-03-26 因赛特公司 Fgfr抑制剂的盐
US11485734B2 (en) 2018-10-02 2022-11-01 Northwestern University Beta-carbolines as positive allosteric modulators of the human serotonin receptor 2C (5-HT2C)
CN116693449A (zh) 2022-03-04 2023-09-05 上海致根医药科技有限公司 用作tyk2抑制剂的化合物、其制备方法及其在医药上的应用

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8119655B2 (en) * 2005-10-07 2012-02-21 Takeda Pharmaceutical Company Limited Kinase inhibitors
CA2725754C (en) * 2008-06-11 2017-05-23 Hazel Joan Dyke Diazacarbazoles and methods of use

Also Published As

Publication number Publication date
US20110178053A1 (en) 2011-07-21
AR072084A1 (es) 2010-08-04
AU2009259114B2 (en) 2013-05-23
WO2009150381A2 (fr) 2009-12-17
MX2010013699A (es) 2011-02-23
ECSP10010670A (es) 2011-01-31
AU2009259114A1 (en) 2009-12-17
TW201002711A (en) 2010-01-16
CO6280536A2 (es) 2011-05-20
KR20110016998A (ko) 2011-02-18
IL209840A0 (en) 2011-02-28
CR11814A (es) 2011-01-10
MA32460B1 (fr) 2011-07-03
NZ589839A (en) 2012-07-27
NI201000210A (es) 2011-05-09
JP2011522867A (ja) 2011-08-04
UY31895A (es) 2010-01-29
DOP2010000366A (es) 2010-12-31
SV2010003754A (es) 2011-03-15
CN102124007A (zh) 2011-07-13
WO2009150381A3 (fr) 2010-02-18
EA018945B1 (ru) 2013-11-29
PE20110122A1 (es) 2011-03-07
CA2725093A1 (fr) 2009-12-17
BRPI0915204A2 (pt) 2019-01-15
EP2303882A2 (fr) 2011-04-06
EA201170002A1 (ru) 2011-08-30
ZA201008387B (en) 2012-02-29

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