SI2099826T1 - Anti-beta-amiloidno protitelo in njegova uporaba - Google Patents
Anti-beta-amiloidno protitelo in njegova uporabaInfo
- Publication number
- SI2099826T1 SI2099826T1 SI200831130T SI200831130T SI2099826T1 SI 2099826 T1 SI2099826 T1 SI 2099826T1 SI 200831130 T SI200831130 T SI 200831130T SI 200831130 T SI200831130 T SI 200831130T SI 2099826 T1 SI2099826 T1 SI 2099826T1
- Authority
- SI
- Slovenia
- Prior art keywords
- beta
- amyloid antibody
- amyloid
- antibody
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/531—Production of immunochemical test materials
- G01N33/532—Production of labelled immunochemicals
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
- G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/77—Internalization into the cell
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/28—Neurological disorders
- G01N2800/2814—Dementia; Cognitive disorders
- G01N2800/2821—Alzheimer
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Molecular Biology (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Microbiology (AREA)
- Pathology (AREA)
- General Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Physics & Mathematics (AREA)
- Food Science & Technology (AREA)
- Biotechnology (AREA)
- Cell Biology (AREA)
- Psychology (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Cardiology (AREA)
Applications Claiming Priority (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US87883107P | 2007-01-05 | 2007-01-05 | |
EP07000211 | 2007-01-05 | ||
US93429107P | 2007-06-11 | 2007-06-11 | |
EP07020341 | 2007-10-17 | ||
PCT/EP2008/000053 WO2008081008A1 (en) | 2007-01-05 | 2008-01-07 | Method of providing disease-specific binding molecules and targets |
EP08700998.1A EP2099826B1 (en) | 2007-01-05 | 2008-01-07 | Anti-beta-amyloid antibody and uses thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
SI2099826T1 true SI2099826T1 (sl) | 2014-02-28 |
Family
ID=39186163
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SI200831845T SI2436696T1 (sl) | 2007-01-05 | 2008-01-07 | Anti-beta-amiloidno protitelo in načini njegove uporabe |
SI200831130T SI2099826T1 (sl) | 2007-01-05 | 2008-01-07 | Anti-beta-amiloidno protitelo in njegova uporaba |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SI200831845T SI2436696T1 (sl) | 2007-01-05 | 2008-01-07 | Anti-beta-amiloidno protitelo in načini njegove uporabe |
Country Status (20)
Country | Link |
---|---|
US (1) | US8906367B2 (sl) |
EP (5) | EP2426143B1 (sl) |
JP (1) | JP5398545B2 (sl) |
KR (4) | KR101735257B1 (sl) |
CN (3) | CN103408661B (sl) |
AU (1) | AU2008203703C1 (sl) |
BR (1) | BRPI0806328B8 (sl) |
CA (2) | CA2764852C (sl) |
CY (1) | CY1119197T1 (sl) |
DK (3) | DK2426143T3 (sl) |
EA (2) | EA017611B1 (sl) |
ES (3) | ES2641897T3 (sl) |
HU (2) | HUE034512T2 (sl) |
LT (1) | LT2436696T (sl) |
MX (1) | MX2009007136A (sl) |
PL (3) | PL2426143T3 (sl) |
PT (3) | PT2099826E (sl) |
SG (1) | SG177954A1 (sl) |
SI (2) | SI2436696T1 (sl) |
WO (1) | WO2008081008A1 (sl) |
Families Citing this family (99)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IL199534A (en) | 2007-01-05 | 2013-01-31 | Univ Zuerich | An isolated human antibody capable of detecting a neoepitope in a disease-related protein, a polynucleotide encoding an antibody, a vector containing the polynucleotide, a host cell containing the polynucleotide or vector, a preparation containing the antibody and related methods and uses. |
MX2009007136A (es) * | 2007-01-05 | 2009-09-24 | Univ Zuerich | Metodos para suministrar moleculas y objetivos de enlace especificos de enfermedades. |
ES2523194T3 (es) | 2007-03-13 | 2014-11-21 | University Of Zurich | Anticuerpo monoclonal humano específico para cada tumor |
EP2321348A2 (en) * | 2008-07-09 | 2011-05-18 | University of Zürich | Method of promoting neurogenesis |
EP2186827A1 (en) | 2008-11-14 | 2010-05-19 | HS LifeSciences Ltd. | Surrogate marker directed cDNA cloning of selectively induced mRNAs |
SG172121A1 (en) | 2008-12-19 | 2011-07-28 | Panima Pharmaceuticals Ag | Human anti-alpha-synuclein autoantibodies |
FR2945538B1 (fr) * | 2009-05-12 | 2014-12-26 | Sanofi Aventis | Anticorps humanises specifiques de la forme protofibrillaire du peptide beta-amyloide. |
US9034333B2 (en) | 2010-08-27 | 2015-05-19 | University Of Zurich | Method for target and drug validation in inflammatory and/or cardiovascular diseases |
US20130156785A1 (en) | 2010-08-27 | 2013-06-20 | University Of Zurich | Novel diagnostic and therapeutic target in inflammatory and/or cardiovascular diseases |
BR112013008765B8 (pt) | 2010-10-11 | 2023-05-02 | Biogen Idec Int Neuroscience Gmbh | Anticorpos monoclonais anti-tau humano isolados ou um fragmento de ligação à tau dos mesmos, métodos de preparação dos mesmos, polinucleotídeo ou polinucleotídeos, vetor ou vetores, composição, método in vitro de diagnóstico ou monitoramento da progressão de uma tauopatia neurodegenerativa em um indivíduo humano, método in vitro para diagnosticar uma tauopatia neurodegenerativa em um indivíduo humano, e kit útil para o diagnóstico de uma tauopatia neurodegenerativa |
KR102568454B1 (ko) | 2010-11-30 | 2023-08-18 | 추가이 세이야쿠 가부시키가이샤 | 복수 분자의 항원에 반복해서 결합하는 항원 결합 분자 |
US9283271B2 (en) | 2010-12-17 | 2016-03-15 | Neurimmune Holding Ag | Human anti-SOD1 antibodies |
WO2012113775A1 (en) | 2011-02-21 | 2012-08-30 | University Of Zurich | Ankyrin g and modulators thereof for the treatment of neurodegenerative disorders |
AU2012233313C1 (en) | 2011-03-30 | 2017-08-03 | Chugai Seiyaku Kabushiki Kaisha | Method for altering plasma retention and immunogenicity of antigen-binding molecule |
US20140302532A1 (en) | 2011-04-12 | 2014-10-09 | Quanterix Corporation | Methods of determining a treatment protocol for and/or a prognosis of a patient's recovery from a brain injury |
LT2723379T (lt) | 2011-06-23 | 2018-10-25 | Biogen International Neuroscience Gmbh | Anti-alfa sinukleiną rišančios molekulės |
EP2762493B1 (en) | 2011-09-30 | 2021-06-09 | Chugai Seiyaku Kabushiki Kaisha | Antigen-binding molecule promoting disappearance of antigens having plurality of biological activities |
KR20230066646A (ko) | 2011-09-30 | 2023-05-16 | 추가이 세이야쿠 가부시키가이샤 | 항원의 소실을 촉진시키는 항원 결합 분자 |
TW201817744A (zh) | 2011-09-30 | 2018-05-16 | 日商中外製藥股份有限公司 | 具有促進抗原清除之FcRn結合域的治療性抗原結合分子 |
US10556949B2 (en) | 2011-09-30 | 2020-02-11 | Chugai Seiyaku Kabushiki Kaisha | Antigen-binding molecule inducing immune response to target antigen |
EP2765192A4 (en) | 2011-10-05 | 2015-04-15 | Chugai Pharmaceutical Co Ltd | ANTIGEN BINDING MOLECULE FOR PROMOTING THE PLASMA CLAIR OF AN ANTIGEN COMPRISING A SACCHARIDIC CHAIN TYPE RECEPTOR BINDING DOMAIN |
AU2012322721B2 (en) * | 2011-10-11 | 2016-05-05 | Vaccinex, Inc. | Use of semaphorin-4D binding molecules for modulation of blood brain barrier permeability |
WO2013063086A1 (en) * | 2011-10-24 | 2013-05-02 | Intellect Neurosciences, Inc. | Compositions and methods for treatment of proteinopathies |
US9587014B2 (en) | 2011-10-28 | 2017-03-07 | Biogen International Neuroscience Gmbh | TDP-43 specific binding molecules |
WO2013066818A1 (en) | 2011-11-02 | 2013-05-10 | Biogen Idec International Neuroscience Gmbh | USE OF AN ANTI-α-SYNUCLEIN ANTIBODY TO DIAGNOSE AN ELEVATED LEVEL OF α-SYNUCLEIN IN THE BRAIN |
KR20210074395A (ko) | 2011-11-30 | 2021-06-21 | 추가이 세이야쿠 가부시키가이샤 | 면역 복합체를 형성하는 세포내로의 운반체(캐리어)를 포함하는 의약 |
DE102011057019A1 (de) * | 2011-12-23 | 2013-06-27 | Forschungszentrum Jülich GmbH | Standard zur Quantifizierung von pathogenen Aggregaten aus körpereigenen Proteinen |
CA2861695C (en) | 2011-12-28 | 2021-03-30 | Immunoqure Ag | Method of isolating human antibodies |
TWI593705B (zh) | 2011-12-28 | 2017-08-01 | Chugai Pharmaceutical Co Ltd | Humanized anti-epiregulin antibody and cancer therapeutic agent containing the antibody as an active ingredient |
US10131709B2 (en) | 2011-12-28 | 2018-11-20 | Immunoqure Ag | Nucleic acid molecules encoding monoclonal antibodies specific for IL-22 |
JP6342333B2 (ja) * | 2012-01-27 | 2018-06-13 | プロセナ バイオサイエンシーズ リミテッド | α−シヌクレインを認識するヒト化抗体 |
CN104204204A (zh) | 2012-02-09 | 2014-12-10 | 中外制药株式会社 | 抗体的Fc区变异体 |
TWI682939B (zh) | 2012-02-24 | 2020-01-21 | 日商中外製藥股份有限公司 | 經FcγRIIB促進抗原消失之抗原結合分子 |
WO2013180201A1 (ja) | 2012-05-30 | 2013-12-05 | 中外製薬株式会社 | 会合化した抗原を消失させる抗原結合分子 |
TWI617578B (zh) | 2012-05-30 | 2018-03-11 | Chugai Pharmaceutical Co Ltd | 標的組織專一的抗原結合分子 |
US20150315267A1 (en) * | 2012-12-07 | 2015-11-05 | Thierry Bussiere | A method of reducing brain amyloid plaques using anti-ab antibodies |
CA2896066C (en) | 2012-12-21 | 2022-07-12 | Biogen Ma Inc. | Human anti-tau antibodies |
EP2970378B1 (en) | 2013-03-15 | 2021-05-26 | Biogen MA Inc. | Hydrophobic interaction protein chromatography under no-salt conditions |
TW201542591A (zh) | 2013-06-24 | 2015-11-16 | Chugai Pharmaceutical Co Ltd | 含有以人源化抗Epiregulin抗體爲有效成分的腺癌以外的非小細胞肺癌之治療劑 |
EP3018143B1 (en) * | 2013-07-03 | 2019-05-29 | Seoul National University R&DB Foundation | Chicken antibody transformed into cysteine and site-specific conjugation using same |
WO2015006475A1 (en) * | 2013-07-12 | 2015-01-15 | Biogen Idec International Neuroscience Gmbh | Genetic and image biomarkers associated with decline in cognitive measures and brain glucose metabolism in populations with alzheimer's disease or those susceptible to developing alzheimer's disease |
US20160229922A1 (en) | 2013-09-20 | 2016-08-11 | Chugai Seiyaku Kabushiki Kaisha | Treatment for hemorrhagic diseases by anti-protein-c antibody |
KR102399292B1 (ko) * | 2013-11-21 | 2022-05-17 | 에프. 호프만-라 로슈 아게 | 항-알파-시누클레인 항체 및 사용 방법 |
CN105980557B (zh) | 2013-12-04 | 2020-04-07 | 中外制药株式会社 | 抗原结合能力根据化合物的浓度而变化的抗原结合分子及其文库 |
JP6623159B2 (ja) * | 2013-12-20 | 2019-12-18 | ニューリミューン ホールディング エイジー | トランスサイレチン(ttr)アミロイドーシスに対する抗体療法及びそのためのヒト由来抗体 |
ZA201608812B (en) * | 2014-06-26 | 2019-08-28 | Janssen Vaccines & Prevention Bv | Antibodies and antigen-binding fragments that specifically bind to microtubule-associated protein tau |
SG11201610459XA (en) * | 2014-06-26 | 2017-01-27 | Janssen Vaccines & Prevention Bv | Antibodies and antigen-binding fragments that specifically bind to microtubule-associated protein tau |
MX2017001285A (es) | 2014-07-29 | 2017-04-25 | Neurimmune Holding Ag | Anticuerpos anti-huntingtina (htt) derivados de humano y usos de los mismos. |
WO2016050822A2 (en) | 2014-09-30 | 2016-04-07 | Neurimmune Holding Ag | Human-derived anti-dipeptide repeats (dprs) antibody |
MA41115A (fr) | 2014-12-02 | 2017-10-10 | Biogen Int Neuroscience Gmbh | Procédé de traitement de la maladie d'alzheimer |
WO2016164833A1 (en) | 2015-04-08 | 2016-10-13 | Nantomics, Llc | Cancer neoepitopes |
JP7236216B2 (ja) | 2015-04-23 | 2023-03-09 | ナントミクス,エルエルシー | がんのネオエピトープ |
MX2018004542A (es) * | 2015-10-12 | 2018-11-22 | Nantomics Llc | Neoepítopos virales y sus usos. |
WO2017066357A1 (en) | 2015-10-12 | 2017-04-20 | Nantomics, Llc | Systems, compositions, and methods for discovery of msi and neoepitopes that predict sensitivity to checkpoint inhibitors |
US11340225B2 (en) * | 2016-03-14 | 2022-05-24 | Biogen International Neuroscience Gmbh | Antibody-dependent cell-mediated phagocytosis assay for reliably measuring uptake of aggregated proteins |
US11542332B2 (en) | 2016-03-26 | 2023-01-03 | Bioatla, Inc. | Anti-CTLA4 antibodies, antibody fragments, their immunoconjugates and uses thereof |
EP3448874A4 (en) | 2016-04-29 | 2020-04-22 | Voyager Therapeutics, Inc. | COMPOSITIONS FOR TREATING A DISEASE |
SG11201809331RA (en) | 2016-05-02 | 2018-11-29 | Prothena Biosciences Ltd | Antibodies recognizing tau |
CN109219615B (zh) | 2016-05-02 | 2022-12-09 | 普罗塞纳生物科学有限公司 | 识别tau的抗体 |
EP3464350A1 (en) | 2016-06-07 | 2019-04-10 | Biogen International Neuroscience GmbH | Methods for treating alzheimer's disease |
EP3478311A4 (en) * | 2016-06-29 | 2021-01-06 | The Regents of the University of California | STRUCTURE-BASED PEPTIDE INHIBITORS OF THE ALPHA-SYNUCLEIN AGGREGATION |
JP2018035137A (ja) | 2016-07-13 | 2018-03-08 | マブイミューン ダイアグノスティックス エイジーMabimmune Diagnostics Ag | 新規な抗線維芽細胞活性化タンパク質(fap)結合薬剤およびその使用 |
EP3487880A1 (en) | 2016-07-25 | 2019-05-29 | Biogen MA Inc. | Anti-hspa5 (grp78) antibodies and uses thereof |
US10662226B2 (en) | 2016-10-28 | 2020-05-26 | The Regents of the University of Caiifomia | Synthetic beta-amyloid peptides capable of forming stable antigenic oligomers |
US20200031895A1 (en) | 2016-12-16 | 2020-01-30 | Biogen Ma Inc. | Stabilized proteolytically activated growth differentiation factor 11 |
EP3583123A1 (en) | 2017-02-17 | 2019-12-25 | Denali Therapeutics Inc. | Anti-tau antibodies and methods of use thereof |
KR101989383B1 (ko) * | 2017-04-04 | 2019-06-14 | 조선대학교산학협력단 | 알츠하이머성 치매의 조기진단을 위한 펩타이드 프로브 |
BR112019022906A2 (pt) | 2017-05-02 | 2020-05-26 | Prothena Biosciences Limited | Anticorpos que reconhecem tau |
CN109201128A (zh) * | 2017-07-05 | 2019-01-15 | 京东方科技集团股份有限公司 | 微流控芯片、化学发光免疫分析系统和分析方法 |
FI3672631T3 (fi) | 2017-08-22 | 2023-06-29 | Biogen Ma Inc | Beeta-amyloidin vasta-aineita sisältäviä lääkekoostumuksia |
CN108484761B (zh) * | 2018-03-10 | 2021-04-30 | 吉林大学 | 一种特异性识别并诱导Aβ42的寡聚体及原纤维解聚的单链抗体、单链抗体基因及其应用 |
CN108874749B (zh) * | 2018-06-22 | 2022-10-14 | 西南科技大学 | 一种高考志愿录取概率模型的建立方法 |
EP3819311A4 (en) | 2018-07-17 | 2022-08-17 | Jiangsu Hengrui Medicine Co., Ltd. | ANTI-ABETA ANTIBODY, ANTIGEN-BINDING FRAGMENT THEREOF AND APPLICATION THEREOF |
EP3836966A4 (en) * | 2018-08-17 | 2022-06-08 | Ab Studio Inc. | CATALYTIC ANTIBODIES AND THEIR METHODS OF USE |
MX2021003867A (es) * | 2018-10-04 | 2021-09-08 | Georg August Univ Goettingen Stiftung Oeffentlichen Rechts Univsmedizin | Anticuerpo monoclonal beta amiloide anti-n-truncado humanizado. |
CA3117409A1 (en) | 2018-10-29 | 2020-05-07 | Biogen Ma Inc. | Humanized and stabilized fc5 variants for enhancement of blood brain barrier transport |
CN111518207B (zh) * | 2019-02-01 | 2022-03-29 | 长春金赛药业有限责任公司 | 人源化抗Aβ单克隆抗体及其应用 |
CN111518206B (zh) * | 2019-02-01 | 2022-03-29 | 长春金赛药业有限责任公司 | 人源化抗Aβ单克隆抗体及其应用 |
CN111518205B (zh) * | 2019-02-01 | 2022-03-29 | 长春金赛药业有限责任公司 | 人源化抗Aβ单克隆抗体及其应用 |
KR102135130B1 (ko) * | 2019-02-15 | 2020-07-17 | 충북대학교 산학협력단 | 트랜스타이레틴 단백질에 특이적으로 결합하는 dna 앱타머 및 이의 용도 |
JP2022524588A (ja) | 2019-03-03 | 2022-05-09 | プロセナ バイオサイエンシーズ リミテッド | タウ認識抗体 |
US11851487B2 (en) * | 2019-04-01 | 2023-12-26 | Rensselaer Polytechnic Institute | Methods and systems for detecting peptide aggregates |
CN114599393A (zh) | 2019-10-22 | 2022-06-07 | 比奥根Ma公司 | 治疗阿尔茨海默病的抗β-淀粉样蛋白抗体 |
WO2021079002A2 (en) | 2019-10-24 | 2021-04-29 | Novago Therapeutics Ag | Novel anti-nogo-a antibodies |
KR20210095781A (ko) | 2020-01-24 | 2021-08-03 | 주식회사 에이프릴바이오 | 항원결합 단편 및 생리활성 이펙터 모이어티로 구성된 융합 컨스트럭트를 포함하는 다중결합항체 및 이를 포함하는 약학조성물 |
EP4106819A1 (en) | 2020-02-21 | 2022-12-28 | Silverback Therapeutics, Inc. | Nectin-4 antibody conjugates and uses thereof |
US20230183304A1 (en) | 2020-05-19 | 2023-06-15 | Robinoo BARBOUR | Multi-Epitope Vaccine for the Treatment of Alzheimer's Disease |
WO2021245184A1 (en) | 2020-06-02 | 2021-12-09 | Neurimmune Ag | HUMAN ANTIBODIES AGAINST SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS-2 (SARS-CoV-2) |
EP4171743A4 (en) | 2020-06-24 | 2024-07-24 | Prothena Biosciences Ltd | SORTILIN-RECOGNIZING ANTIBODIES |
WO2022006327A1 (en) | 2020-07-01 | 2022-01-06 | Silverback Therapeutics, Inc. | Anti-asgr1 antibody conjugates and uses thereof |
JP2023535024A (ja) | 2020-07-23 | 2023-08-15 | オター プロシーナ リミテッド | 抗aベータ抗体 |
WO2022144406A1 (en) | 2020-12-29 | 2022-07-07 | Neurimmune Ag | Human anti-tau antibodies |
TW202300517A (zh) | 2021-03-12 | 2023-01-01 | 美商美國禮來大藥廠 | 抗類澱粉β抗體及其用途 |
EP4320242A1 (en) | 2021-04-08 | 2024-02-14 | Sana Biotechnology, Inc. | Cd8-specific antibody constructs and compositions thereof |
WO2022251048A1 (en) | 2021-05-24 | 2022-12-01 | Eli Lilly And Company | Anti-amyloid beta antibodies and uses thereof |
KR20240035444A (ko) | 2021-06-11 | 2024-03-15 | 세이지 테라퓨틱스, 인크. | 알츠하이머병 치료를 위한 신경활성 스테로이드 |
CA3239708A1 (en) | 2021-12-03 | 2023-06-08 | Aubin MICHALON | Novel potency assay for antibody-based drugs and useful means therefor |
CN117586388A (zh) * | 2022-08-09 | 2024-02-23 | 深圳智源生物医药有限公司 | 改进的β淀粉样蛋白寡聚体特异性结合抗体 |
CN117157527A (zh) * | 2023-02-28 | 2023-12-01 | 湖南乾康科技有限公司 | 一种用于定量检测尿液淀粉样前体蛋白片段的酶联免疫检测方法 |
Family Cites Families (125)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4444887A (en) | 1979-12-10 | 1984-04-24 | Sloan-Kettering Institute | Process for making human antibody producing B-lymphocytes |
US4716111A (en) | 1982-08-11 | 1987-12-29 | Trustees Of Boston University | Process for producing human antibodies |
US4741900A (en) | 1982-11-16 | 1988-05-03 | Cytogen Corporation | Antibody-metal ion complexes |
US4694778A (en) | 1984-05-04 | 1987-09-22 | Anicon, Inc. | Chemical vapor deposition wafer boat |
AU584417B2 (en) | 1985-04-01 | 1989-05-25 | Lonza Group Ag | Transformed myeloma cell-line and a process for the expression of a gene coding for a eukaryotic polypeptide employing same |
GB8601597D0 (en) | 1986-01-23 | 1986-02-26 | Wilson R H | Nucleotide sequences |
GB8607679D0 (en) | 1986-03-27 | 1986-04-30 | Winter G P | Recombinant dna product |
AU612370B2 (en) | 1987-05-21 | 1991-07-11 | Micromet Ag | Targeted multifunctional proteins |
US5892019A (en) | 1987-07-15 | 1999-04-06 | The United States Of America, As Represented By The Department Of Health And Human Services | Production of a single-gene-encoded immunoglobulin |
GB8717430D0 (en) | 1987-07-23 | 1987-08-26 | Celltech Ltd | Recombinant dna product |
KR900700134A (ko) | 1988-04-15 | 1990-08-11 | 원본미기재 | Il-2 수용체-특이적 키메릭 항체 |
DE68921982D1 (de) | 1988-06-14 | 1995-05-04 | Cetus Oncology Corp | Kupplungsmittel und sterisch gehinderte, mit disulfid gebundene konjugate daraus. |
US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
IL162181A (en) | 1988-12-28 | 2006-04-10 | Pdl Biopharma Inc | A method of producing humanized immunoglubulin, and polynucleotides encoding the same |
US5225538A (en) | 1989-02-23 | 1993-07-06 | Genentech, Inc. | Lymphocyte homing receptor/immunoglobulin fusion proteins |
US5116964A (en) | 1989-02-23 | 1992-05-26 | Genentech, Inc. | Hybrid immunoglobulins |
IE63847B1 (en) | 1989-05-05 | 1995-06-14 | Res Dev Foundation | A novel antibody delivery system for biological response modifiers |
US6150584A (en) | 1990-01-12 | 2000-11-21 | Abgenix, Inc. | Human antibodies derived from immunized xenomice |
DK0463151T3 (da) | 1990-01-12 | 1996-07-01 | Cell Genesys Inc | Frembringelse af xenogene antistoffer |
US5314995A (en) | 1990-01-22 | 1994-05-24 | Oncogen | Therapeutic interleukin-2-antibody based fusion proteins |
WO1991014438A1 (en) | 1990-03-20 | 1991-10-03 | The Trustees Of Columbia University In The City Of New York | Chimeric antibodies with receptor binding ligands in place of their constant region |
GB9020282D0 (en) | 1990-09-17 | 1990-10-31 | Gorman Scott D | Altered antibodies and their preparation |
CA2095836C (en) | 1990-11-09 | 1999-04-06 | Stephen D. Gillies | Cytokine immunoconjugates |
IE922437A1 (en) | 1991-07-25 | 1993-01-27 | Idec Pharma Corp | Recombinant antibodies for human therapy |
ES2301158T3 (es) | 1992-07-24 | 2008-06-16 | Amgen Fremont Inc. | Produccion de anticuerpos xenogenicos. |
CA2135642C (en) | 1992-08-21 | 1999-12-14 | James G. Barsoum | Tat-derived transport polypeptides |
WO1994009817A1 (en) | 1992-11-04 | 1994-05-11 | City Of Hope | Novel antibody construct |
US5736137A (en) | 1992-11-13 | 1998-04-07 | Idec Pharmaceuticals Corporation | Therapeutic application of chimeric and radiolabeled antibodies to human B lymphocyte restricted differentiation antigen for treatment of B cell lymphoma |
EP0669986B1 (en) | 1992-11-13 | 2003-04-09 | Idec Pharmaceuticals Corporation | Fully impaired consensus kozac sequences for mammalian expression |
US5876950A (en) * | 1995-01-26 | 1999-03-02 | Bristol-Myers Squibb Company | Monoclonal antibodies specific for different epitopes of human GP39 and methods for their use in diagnosis and therapy |
US6130364A (en) | 1995-03-29 | 2000-10-10 | Abgenix, Inc. | Production of antibodies using Cre-mediated site-specific recombination |
CA2761116A1 (en) | 1995-04-27 | 1996-10-31 | Amgen Fremont Inc. | Human antibodies derived from immunized xenomice |
CA2219486A1 (en) | 1995-04-28 | 1996-10-31 | Abgenix, Inc. | Human antibodies derived from immunized xenomice |
US5875396A (en) * | 1995-11-13 | 1999-02-23 | Wytec, Incorporated | Multichannel radio frequency transmission system to deliver wideband digital data into independent sectorized service areas |
GB9524973D0 (en) | 1995-12-06 | 1996-02-07 | Lynxvale Ltd | Viral vectors |
US5916771A (en) | 1996-10-11 | 1999-06-29 | Abgenix, Inc. | Production of a multimeric protein by cell fusion method |
US6420140B1 (en) | 1996-10-11 | 2002-07-16 | Abgenix, Inc. | Production of multimeric protein by cell fusion method |
DK0942968T3 (da) | 1996-12-03 | 2008-06-23 | Amgen Fremont Inc | Fuldt humane antistoffer, der binder EGFR |
AU737155B2 (en) | 1997-03-14 | 2001-08-09 | Biogen Idec Inc. | Method for integrating genes at specific sites in mammalian cells via homologous recombination and vectors for accomplishing the same |
US20020086847A1 (en) * | 1997-04-09 | 2002-07-04 | Mindset Biopharmaceuticals (Usa) | Recombinant antibodies specific for beta-amyloid ends, DNA encoding and methods of use thereof |
US8173127B2 (en) * | 1997-04-09 | 2012-05-08 | Intellect Neurosciences, Inc. | Specific antibodies to amyloid beta peptide, pharmaceutical compositions and methods of use thereof |
PT994728E (pt) | 1997-04-09 | 2008-11-11 | Intellect Neurosciences Inc | Anticorpos recombinantes específicos contra terminações beta-amilóide, codificação por adn e métodos de utilização destes |
EP0970126B1 (en) | 1997-04-14 | 2001-04-18 | Micromet AG | Novel method for the production of antihuman antigen receptors and uses thereof |
US6235883B1 (en) | 1997-05-05 | 2001-05-22 | Abgenix, Inc. | Human monoclonal antibodies to epidermal growth factor receptor |
GB2339430A (en) | 1997-05-21 | 2000-01-26 | Biovation Ltd | Method for the production of non-immunogenic proteins |
US6703015B1 (en) * | 1999-09-03 | 2004-03-09 | Ramot At Tel-Aviv University Ltd. | Filamentous bacteriophage displaying an β-amyloid epitope |
US6750324B1 (en) * | 1997-12-02 | 2004-06-15 | Neuralab Limited | Humanized and chimeric N-terminal amyloid beta-antibodies |
US20080050367A1 (en) * | 1998-04-07 | 2008-02-28 | Guriq Basi | Humanized antibodies that recognize beta amyloid peptide |
US6743427B1 (en) | 1997-12-02 | 2004-06-01 | Neuralab Limited | Prevention and treatment of amyloidogenic disease |
US6710226B1 (en) | 1997-12-02 | 2004-03-23 | Neuralab Limited | Transgenic mouse assay to determine the effect of Aβ antibodies and Aβ Fragments on alzheimer's disease characteristics |
US6913745B1 (en) | 1997-12-02 | 2005-07-05 | Neuralab Limited | Passive immunization of Alzheimer's disease |
TWI239847B (en) | 1997-12-02 | 2005-09-21 | Elan Pharm Inc | N-terminal fragment of Abeta peptide and an adjuvant for preventing and treating amyloidogenic disease |
US7964192B1 (en) | 1997-12-02 | 2011-06-21 | Janssen Alzheimer Immunotherapy | Prevention and treatment of amyloidgenic disease |
US6761888B1 (en) * | 2000-05-26 | 2004-07-13 | Neuralab Limited | Passive immunization treatment of Alzheimer's disease |
US7179892B2 (en) | 2000-12-06 | 2007-02-20 | Neuralab Limited | Humanized antibodies that recognize beta amyloid peptide |
US7462605B2 (en) * | 1998-01-23 | 2008-12-09 | Celmed Oncology (Usa), Inc. | Phosphoramidate compounds and methods of use |
WO2000011208A1 (en) | 1998-08-25 | 2000-03-02 | University Of Washington | Rapid quantitative analysis of proteins or protein function in complex mixtures |
AU1631700A (en) | 1998-11-23 | 2000-06-13 | Idec Pharmaceuticals Corporation | Tumor antigen-specific antibody-gp39 chimeric protein constructs |
AU776910B2 (en) | 1998-12-08 | 2004-09-23 | Merck Patent Gesellschaft Mit Beschrankter Haftung | Modifying protein immunogenicity |
US6361973B1 (en) * | 1999-03-22 | 2002-03-26 | Novozymes Biotech, Inc. | Promoters for expressing genes in a fungal cell |
US6787637B1 (en) * | 1999-05-28 | 2004-09-07 | Neuralab Limited | N-Terminal amyloid-β antibodies |
UA81216C2 (en) | 1999-06-01 | 2007-12-25 | Prevention and treatment of amyloid disease | |
DE19932958C2 (de) | 1999-07-14 | 2003-08-07 | Walter Schubert | Vorrichtung zur Bindung von Molekülen, Molekülgruppen, Molekülteilen und/oder Zellen |
IL142948A0 (en) | 1999-09-03 | 2002-04-21 | Univ Ramot | Agents and compositions and methods utilizing same useful in diagnosing and/or treating or preventing plaque forming diseases |
US6187309B1 (en) * | 1999-09-14 | 2001-02-13 | Milkaus Laboratory, Inc. | Method for treatment of symptoms of central nervous system disorders |
US6713058B2 (en) * | 1999-09-14 | 2004-03-30 | Milkhaus Laboratory, Inc. | Methods for alleviating symptoms associated with neuropathic conditions comprising administration of low levels of antibodies |
US6436401B1 (en) * | 1999-09-14 | 2002-08-20 | Milkhaus Laboratory, Inc. | Methods for alleviating symptoms associated with diabetes and diabetic neuropathy comprising administration of low levels of antibodies |
US6294171B2 (en) * | 1999-09-14 | 2001-09-25 | Milkhaus Laboratory, Inc. | Methods for treating disease states comprising administration of low levels of antibodies |
EP2082749A3 (en) * | 2000-07-07 | 2010-06-30 | Bioarctic Neuroscience AB | Prevention and treatment of Alzheimer's disease |
EP1172378A1 (en) | 2000-07-12 | 2002-01-16 | Richard Dr. Dodel | Human beta-amyloid antibody and use thereof for treatment of alzheimer's disease |
EP1340088B1 (en) | 2000-11-17 | 2007-01-17 | University Of Rochester | In vitro methods of producing and identifying immunoglobulin molecules in eukaryotic cells |
US7700751B2 (en) * | 2000-12-06 | 2010-04-20 | Janssen Alzheimer Immunotherapy | Humanized antibodies that recognize β-amyloid peptide |
US6716226B2 (en) * | 2001-06-25 | 2004-04-06 | Inscope Development, Llc | Surgical clip |
PE20020574A1 (es) | 2000-12-06 | 2002-07-02 | Wyeth Corp | Anticuerpos humanizados que reconocen el peptido amiloideo beta |
AU2002327164A1 (en) | 2001-01-29 | 2002-12-09 | Idec Pharmaceuticals Corporation | Engineered tetravalent antibodies and methods of use |
AU2002240120B2 (en) | 2001-01-29 | 2008-05-08 | Biogen Idec Inc. | Modified antibodies and methods of use |
ES2391905T3 (es) * | 2001-08-17 | 2012-11-30 | Washington University | Método de ensayo para la enfermedad de alzheimer |
US20030157641A1 (en) | 2001-11-16 | 2003-08-21 | Idec Pharmaceuticals Corporation | Polycistronic expression of antibodies |
US7390885B2 (en) * | 2001-11-26 | 2008-06-24 | Cell Matrix, Inc. | Humanized collagen antibodies and related methods |
MY139983A (en) * | 2002-03-12 | 2009-11-30 | Janssen Alzheimer Immunotherap | Humanized antibodies that recognize beta amyloid peptide |
US20110200609A1 (en) * | 2002-09-12 | 2011-08-18 | The Regents Of The University Of California | Monoclonal antibodies specific for pathological amyloid aggregates common to amyloids formed from proteins of differing sequence |
US8506959B2 (en) | 2002-11-01 | 2013-08-13 | Neotope Biosciences Limited | Prevention and treatment of synucleinopathic and amyloidogenic disease |
WO2008103472A2 (en) | 2007-02-23 | 2008-08-28 | Elan Pharmaceuticals, Inc. | Prevention and treatment of synucleinopathic and amyloidogenic disease |
TW200509968A (en) * | 2002-11-01 | 2005-03-16 | Elan Pharm Inc | Prevention and treatment of synucleinopathic disease |
JP4690046B2 (ja) * | 2002-11-22 | 2011-06-01 | 中外製薬株式会社 | 病巣組織に対する抗体 |
AU2004215125B2 (en) | 2003-02-26 | 2011-01-06 | Institute For Research In Biomedicine | Monoclonal antibody production by EBV transformation of B cells |
WO2004095031A1 (en) | 2003-04-24 | 2004-11-04 | Universität Zürich | Method of monitoring immunotherapy |
TWI306458B (en) | 2003-05-30 | 2009-02-21 | Elan Pharma Int Ltd | Humanized antibodies that recognize beta amyloid peptide |
WO2005018424A2 (en) | 2003-08-18 | 2005-03-03 | Research Foundation For Mental Hygiene, Inc. | Antibodies specific for fibrillar amyloid and a procedure to detect fibrillar amyloid deposits |
JP2007503206A (ja) | 2003-08-22 | 2007-02-22 | バイオジェン・アイデック・エムエイ・インコーポレイテッド | 変更されたエフェクター機能を有する改良された抗体およびその抗体を産生する方法 |
AU2005217596B2 (en) * | 2004-02-23 | 2012-01-19 | Eli Lilly And Company | Anti-ABeta antibody |
WO2005105998A1 (ja) | 2004-04-27 | 2005-11-10 | Juridical Foundation The Chemo-Sero-Therapeutic Research Institute | ヒト抗アミロイドβペプチド抗体およびその抗体フラグメント |
EP1766396B1 (en) | 2004-06-07 | 2010-08-11 | Ramot at Tel-Aviv University Ltd. | Method of passive immunization against disease or disorder characterized by amyloid aggregation with diminished risk of neuroinflammation |
SE0401601D0 (sv) * | 2004-06-21 | 2004-06-21 | Bioarctic Neuroscience Ab | Protofibril specific antibodies and uses thereof |
EA013752B1 (ru) | 2004-08-09 | 2010-06-30 | Элан Фармасьютикалз, Инк. | Предупреждение и лечение синуклеинопатических и амилоидогенных заболеваний |
WO2006050041A2 (en) | 2004-10-28 | 2006-05-11 | Ramot At Tel Aviv University Ltd. | Methods for reducing or inhibiting brain inflammation or for promoting neurogenesis |
US20060257396A1 (en) * | 2004-12-15 | 2006-11-16 | Jacobsen Jack S | Abeta antibodies for use in improving cognition |
US20090035295A1 (en) * | 2005-03-05 | 2009-02-05 | Abbott Gmgh & Co. Kg | Screening Method, Process for Purifying of Non-Diffusible A-Beta Oligomers, Selective Antibodies Against Said Non-Diffusible a-Beta Oligomers and a Process for Manufacturing of Said Antibodies |
JP2006265189A (ja) | 2005-03-24 | 2006-10-05 | Kyoto Univ | βアミロイドペプチド、及びそれを用いたアルツハイマー病治療薬又は予防薬のスクリーニング方法 |
ES2318918B1 (es) | 2005-04-01 | 2010-02-16 | Biotherapix Molecular Medicines, S.L.U. | Anticuerpos humanos con capacidad de union al peptido beta-amiloide y sus aplicaciones. |
MY148086A (en) * | 2005-04-29 | 2013-02-28 | Rinat Neuroscience Corp | Antibodies directed against amyloid-beta peptide and methods using same |
US9133267B2 (en) * | 2005-11-22 | 2015-09-15 | The Trustees Of The University Of Pennsylvania | Antibody treatment of Alzheimer's and related diseases |
CN101528770A (zh) * | 2005-11-30 | 2009-09-09 | 艾博特公司 | 制备重组形式的人β-淀粉样蛋白的方法和这些蛋白质的应用 |
KR101434935B1 (ko) * | 2005-11-30 | 2014-10-01 | 애브비 인코포레이티드 | 아밀로이드 베타 단백질에 대한 모노클로날 항체 및 이의용도 |
EP2289909B1 (en) * | 2005-11-30 | 2014-10-29 | AbbVie Inc. | Screening method, process for purifying of non-diffusible a-beta oligomers, selective antibodies against said non-diffusible a-beta oligomers and a process for manufacturing of said antibodies |
KR101505201B1 (ko) | 2005-12-12 | 2015-03-24 | 에이씨 이뮨 에스.에이. | 치료적 특성을 갖는 베타 1-42 특이적인 단일클론성 항체 |
US8784810B2 (en) * | 2006-04-18 | 2014-07-22 | Janssen Alzheimer Immunotherapy | Treatment of amyloidogenic diseases |
US8455626B2 (en) * | 2006-11-30 | 2013-06-04 | Abbott Laboratories | Aβ conformer selective anti-aβ globulomer monoclonal antibodies |
MX2009007136A (es) * | 2007-01-05 | 2009-09-24 | Univ Zuerich | Metodos para suministrar moleculas y objetivos de enlace especificos de enfermedades. |
KR20100016661A (ko) | 2007-04-18 | 2010-02-12 | 얀센 알츠하이머 이뮤노테라피 | 대뇌 아밀로이드 혈관병증의 예방 및 치료 |
US8003097B2 (en) * | 2007-04-18 | 2011-08-23 | Janssen Alzheimer Immunotherapy | Treatment of cerebral amyloid angiopathy |
ES2498040T3 (es) * | 2007-07-27 | 2014-09-24 | Janssen Alzheimer Immunotherapy | Tratamiento de enfermedades amiloidogénicas con anticuerpos anti-beta humanizados |
JP2010536907A (ja) * | 2007-08-31 | 2010-12-02 | ニューリミューン セラピューティクス エイジー | 患者にアミロイドーシスおよびタンパク質凝集性障害における特異的免疫応答をもたらす方法 |
US20100239570A1 (en) | 2007-09-13 | 2010-09-23 | Roger Nitsch | Moncolonal amyloid beta (abeta) - specific antibody and uses thereof |
JP5400050B2 (ja) * | 2007-10-02 | 2014-01-29 | シーエスエル、リミテッド | 治療用抗体の精製法および使用法 |
JPWO2009051220A1 (ja) | 2007-10-19 | 2011-03-03 | イムナス・ファーマ株式会社 | Aβオリゴマーに特異的に結合する抗体およびその利用 |
GB0720912D0 (en) * | 2007-10-25 | 2007-12-05 | Univ Cardiff | Monoclonal Anitbody for APP |
KR20100097651A (ko) * | 2007-10-29 | 2010-09-03 | 인썸 | 베타-아밀로이드 펩티드에 특이적인 신규 항체 및 진단제 또는 진단약으로서의 그 용도 |
JP5616230B2 (ja) * | 2007-11-16 | 2014-10-29 | ザ ロックフェラー ユニバーシティー | ベータ−アミロイドタンパク質のプロトフィブリルの形態に特異的な抗体 |
EP2246427B1 (en) * | 2008-02-08 | 2016-11-30 | Immunas Pharma, Inc. | Antibodies capable of binding specifically to amyloid beta-oligomers, and use thereof |
EP2321348A2 (en) * | 2008-07-09 | 2011-05-18 | University of Zürich | Method of promoting neurogenesis |
MX2011004891A (es) * | 2008-11-13 | 2011-10-06 | Modgene Llc | Modificacion de la carga de beta amiloide en el tejido no cerebral. |
CN102459335B (zh) * | 2009-04-17 | 2015-11-25 | 伊缪纳斯制药株式会社 | 特异性结合Aβ寡聚体的抗体及其用途 |
ES2614949T3 (es) * | 2009-08-06 | 2017-06-02 | Immunas Pharma, Inc. | Anticuerpos que se unen específicamente a oligómeros beta A y uso de los mismos |
DK2462161T3 (en) * | 2009-08-06 | 2017-06-06 | Immunas Pharma Inc | Antibodies specifically binding to A-beta oligomers and their use |
-
2008
- 2008-01-07 MX MX2009007136A patent/MX2009007136A/es active IP Right Grant
- 2008-01-07 KR KR1020167021950A patent/KR101735257B1/ko active IP Right Grant
- 2008-01-07 EP EP11184418.9A patent/EP2426143B1/en active Active
- 2008-01-07 DK DK11184418.9T patent/DK2426143T3/en active
- 2008-01-07 JP JP2009544399A patent/JP5398545B2/ja active Active
- 2008-01-07 DK DK08700998.1T patent/DK2099826T3/da active
- 2008-01-07 AU AU2008203703A patent/AU2008203703C1/en active Active
- 2008-01-07 ES ES11184418.9T patent/ES2641897T3/es active Active
- 2008-01-07 EP EP17174176.2A patent/EP3239175A1/en not_active Withdrawn
- 2008-01-07 SI SI200831845T patent/SI2436696T1/sl unknown
- 2008-01-07 KR KR1020167002281A patent/KR101700073B1/ko active IP Right Grant
- 2008-01-07 CN CN201310282725.XA patent/CN103408661B/zh active Active
- 2008-01-07 PL PL11184418T patent/PL2426143T3/pl unknown
- 2008-01-07 WO PCT/EP2008/000053 patent/WO2008081008A1/en active Application Filing
- 2008-01-07 CA CA2764852A patent/CA2764852C/en active Active
- 2008-01-07 US US12/522,031 patent/US8906367B2/en active Active
- 2008-01-07 CN CN2012100468084A patent/CN102603893A/zh active Pending
- 2008-01-07 PL PL08700998T patent/PL2099826T3/pl unknown
- 2008-01-07 PT PT87009981T patent/PT2099826E/pt unknown
- 2008-01-07 PT PT111854865T patent/PT2436696T/pt unknown
- 2008-01-07 LT LTEP11185486.5T patent/LT2436696T/lt unknown
- 2008-01-07 BR BRPI0806328A patent/BRPI0806328B8/pt active IP Right Grant
- 2008-01-07 KR KR1020127000738A patent/KR20120017469A/ko active Application Filing
- 2008-01-07 SG SG2012000758A patent/SG177954A1/en unknown
- 2008-01-07 HU HUE11184418A patent/HUE034512T2/en unknown
- 2008-01-07 CA CA2674140A patent/CA2674140C/en active Active
- 2008-01-07 EP EP17169749.3A patent/EP3239174A1/en not_active Withdrawn
- 2008-01-07 ES ES08700998.1T patent/ES2439490T3/es active Active
- 2008-01-07 EP EP11185486.5A patent/EP2436696B8/en active Active
- 2008-01-07 KR KR1020097016340A patent/KR20090114388A/ko not_active IP Right Cessation
- 2008-01-07 PL PL11185486T patent/PL2436696T3/pl unknown
- 2008-01-07 ES ES11185486.5T patent/ES2635317T3/es active Active
- 2008-01-07 EA EA200900954A patent/EA017611B1/ru not_active IP Right Cessation
- 2008-01-07 DK DK11185486.5T patent/DK2436696T3/en active
- 2008-01-07 PT PT111844189T patent/PT2426143T/pt unknown
- 2008-01-07 HU HUE11185486A patent/HUE033325T2/en unknown
- 2008-01-07 CN CN2008800062941A patent/CN101622275B/zh active Active
- 2008-01-07 EA EA201201067A patent/EA029481B1/ru not_active IP Right Cessation
- 2008-01-07 SI SI200831130T patent/SI2099826T1/sl unknown
- 2008-01-07 EP EP08700998.1A patent/EP2099826B1/en active Active
-
2017
- 2017-08-08 CY CY20171100850T patent/CY1119197T1/el unknown
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
PL2099826T3 (pl) | Przeciwciało przeciwko beta-amyloidowi i jego zastosowania | |
HRP20180596T1 (hr) | PROTUTIJELA PROTIV Sp35 I NJIHOVA UPOTREBA | |
EP2236604A4 (en) | ANTI-NR10 ANTIBODIES AND USE THEREOF | |
IL205355A0 (en) | Anti- hepcidin antibodies and uses thereof | |
IL200012A0 (en) | Anti-robo4 antibodies and uses therefor | |
IL196397A0 (en) | Prlr-specific antibody and uses thereof | |
ZA200810311B (en) | Anti-NKG2A antibodies and uses thereof | |
IL209309A0 (en) | Anti-fn14 antibodies and uses thereof | |
IL216731A (en) | And antibodies against p95 – her2 and their uses | |
IL201020A0 (en) | C5 antigens and uses thereof | |
IL201156A0 (en) | ANTI-IgE ANTIBODIES AND USES THEREOF | |
HK1156326A1 (en) | Anti-hepcidin-25 selective antibodies and uses thereof | |
HK1203206A1 (en) | Antibody and use thereof | |
EP2193144A4 (en) | ANTIBODIES TO FLAGELLIN AND APPLICATIONS THEREOF | |
EP2388320A4 (en) | ANTI-HS6ST2 ANTIBODIES AND USE THEREOF | |
EP2128249A4 (en) | ZINC OXIDE FIXING ANTIBODIES AND USE THEREOF | |
GB0812277D0 (en) | Antibody and uses thereof | |
ZA200905136B (en) | Anti-robo4 antibodies and uses therefor | |
GB0711398D0 (en) | Substituted organpolysiloxanes and uses thereof |