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SG11201400679WA - New dihydroquinoline-2-one derivatives - Google Patents

New dihydroquinoline-2-one derivatives

Info

Publication number
SG11201400679WA
SG11201400679WA SG11201400679WA SG11201400679WA SG11201400679WA SG 11201400679W A SG11201400679W A SG 11201400679WA SG 11201400679W A SG11201400679W A SG 11201400679WA SG 11201400679W A SG11201400679W A SG 11201400679WA SG 11201400679W A SG11201400679W A SG 11201400679WA
Authority
SG
Singapore
Prior art keywords
derivatives
dihydroquinoline
new
new dihydroquinoline
Prior art date
Application number
SG11201400679WA
Other languages
English (en)
Inventor
Johannes Aebi
Kurt Amrein
Benoit Hornsperger
Henner Knust
Bernd Kuhn
Yongfu Liu
Hans P Maerki
Alexander V Mayweg
Peter Mohr
Xuefei Tan
Mingwei Zhou
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of SG11201400679WA publication Critical patent/SG11201400679WA/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/12Drugs for disorders of the urinary system of the kidneys
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/38Drugs for disorders of the endocrine system of the suprarenal hormones
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/38Drugs for disorders of the endocrine system of the suprarenal hormones
    • A61P5/42Drugs for disorders of the endocrine system of the suprarenal hormones for decreasing, blocking or antagonising the activity of mineralocorticosteroids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/04Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/06Peri-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/10Spiro-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02Silicon compounds
    • C07F7/08Compounds having one or more C—Si linkages
    • C07F7/18Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804Compounds having Si-O-C linkages

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Hospice & Palliative Care (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
SG11201400679WA 2011-09-15 2012-09-12 New dihydroquinoline-2-one derivatives SG11201400679WA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN2011079673 2011-09-15
PCT/EP2012/067744 WO2013037779A1 (en) 2011-09-15 2012-09-12 New dihydroquinoline-2-one derivatives

Publications (1)

Publication Number Publication Date
SG11201400679WA true SG11201400679WA (en) 2014-04-28

Family

ID=46829775

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11201400679WA SG11201400679WA (en) 2011-09-15 2012-09-12 New dihydroquinoline-2-one derivatives

Country Status (33)

Country Link
US (1) US9260408B2 (es)
EP (2) EP3653618B1 (es)
JP (1) JP6012735B2 (es)
KR (1) KR101785143B1 (es)
CN (1) CN103814021B (es)
AR (1) AR087901A1 (es)
AU (1) AU2012307509B2 (es)
BR (1) BR112014006283B1 (es)
CA (1) CA2846785C (es)
CL (1) CL2014000604A1 (es)
CO (1) CO6890099A2 (es)
CR (1) CR20140091A (es)
DK (1) DK2755963T3 (es)
EA (1) EA035757B1 (es)
EC (1) ECSP14013245A (es)
ES (2) ES3016782T3 (es)
HR (1) HRP20192323T1 (es)
HU (1) HUE047771T2 (es)
IL (1) IL231229A0 (es)
LT (1) LT2755963T (es)
MX (1) MX358376B (es)
MY (1) MY169043A (es)
PE (1) PE20141372A1 (es)
PH (1) PH12014500434A1 (es)
PL (1) PL2755963T3 (es)
PT (1) PT2755963T (es)
RS (1) RS59737B1 (es)
SG (1) SG11201400679WA (es)
SI (1) SI2755963T1 (es)
TW (1) TWI462914B (es)
UA (1) UA111626C2 (es)
WO (1) WO2013037779A1 (es)
ZA (1) ZA201401884B (es)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR112015020834A2 (pt) * 2013-03-08 2017-07-18 Hoffmann La Roche novos derivados hidroquinolina-2-ona como inibidores de aldosterona sintetase (cyp1 1 b2 ou cyp1 1 b1)
CN105073732B (zh) * 2013-03-14 2017-07-21 豪夫迈·罗氏有限公司 用作醛固酮合酶抑制剂的二氢喹啉‑2‑酮衍生物
EP2970198B1 (en) 2013-03-14 2020-08-05 F.Hoffmann-La Roche Ag Dihydroquinoline-2-one derivatives for use as aldosterone synthase inhibitors
JP6542192B2 (ja) 2013-03-14 2019-07-10 ザ ブリガム アンド ウィメンズ ホスピタル インコーポレイテッドThe Brigham and Women’s Hospital, Inc. Bmp阻害剤およびその使用方法
JP6067181B2 (ja) * 2013-04-30 2017-01-25 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング アルドステロンシンターゼ阻害薬
PL3004076T3 (pl) * 2013-05-27 2020-04-30 F.Hoffmann-La Roche Ag Nowe związki 3,4-dihydro-2h-izochinolin-1-onowe i 2,3-dihydroizoindol-1-onowe
HRP20192275T1 (hr) * 2013-05-27 2020-03-06 F. Hoffmann - La Roche Ag Novi spojevi 3,4-dihidro-2h-izokinolin-1-ona i 2,3-dihidro-izoindol-1-ona
CA2911473C (en) * 2013-05-27 2022-05-03 F. Hoffmann-La Roche Ag 3,4-dihydro-2h-isoquinoline-1-one and 2,3-dihydro-isoindol-1-one compounds
WO2015125858A1 (ja) * 2014-02-24 2015-08-27 日本曹達株式会社 ヘテロアリール化合物およびその用途
US20170190705A1 (en) * 2014-03-26 2017-07-06 The Brigham And Woman's Hospital, Inc. Compositions and Methods for Inhibiting BMP
MY176401A (en) 2014-04-24 2020-08-05 Mitsubishi Tanabe Pharma Corp Novel disubstituted 1,2,4-triazine compound
US10513521B2 (en) 2014-07-15 2019-12-24 The Brigham And Women's Hospital, Inc. Compositions and methods for inhibiting BMP
WO2016066597A1 (en) * 2014-10-31 2016-05-06 F. Hoffmann-La Roche Ag New dihydroquinoline pyrazolyl compounds
WO2016066663A1 (en) * 2014-10-31 2016-05-06 F. Hoffmann-La Roche Ag Pyrazolyl-3,4-dihydroquinolin-2-one aldosterone synthase inhibitors
WO2016066662A1 (en) 2014-10-31 2016-05-06 F. Hoffmann-La Roche Ag New dihydroquinoline pyrazolyl compounds as aldosterone synthase inhibitors
UA126372C2 (uk) 2015-08-31 2022-09-28 Тон-А Сосіо Холдінгз Ко., Лтд. Гетероарильні сполуки та їхнє застосування як терапевтичних лікарських засобів
JP6314196B2 (ja) * 2015-10-22 2018-04-18 田辺三菱製薬株式会社 医薬組成物
EP3381904B1 (en) * 2015-10-23 2021-07-28 Mitsubishi Tanabe Pharma Corporation Novel nitrogen-containing aromatic heterocyclic compound
US10913730B2 (en) 2016-10-10 2021-02-09 Dong-A Socio Holdings Co., Ltd. Heteroaryl compounds and their use as Mer inhibitors
CN117285525A (zh) * 2016-12-08 2023-12-26 豪夫迈·罗氏有限公司 作为GABAAα5 PAM的新型异噁唑基醚衍生物
CN113767095A (zh) 2019-05-01 2021-12-07 勃林格殷格翰国际有限公司 (r)-4-溴苯磺酸(2-甲基环氧乙烷-2-基)甲酯
WO2023063851A1 (en) * 2021-10-13 2023-04-20 «Target Medicals» Limited Liability Company Inhibitors of human aldosterone synthase (cyp11b2)
CA3236890A1 (en) 2021-12-14 2023-06-22 Boehringer Ingelheim International Gmbh Aldosterone synthase inhibitors for treating chronic kidney disease
AU2023378302A1 (en) * 2022-11-10 2025-04-10 «Target Medicals» Limited Liability Company Inhibitors of human aldosterone synthase (cyp11b2)
CN120187713A (zh) * 2022-11-23 2025-06-20 上海翰森生物医药科技有限公司 吡啶多环类化合物抑制剂、及其制备方法和应用
WO2024235165A1 (zh) * 2023-05-12 2024-11-21 南京明德新药研发有限公司 含氮杂环类化合物及其应用
WO2025131022A1 (zh) * 2023-12-22 2025-06-26 上海翊石医药科技有限公司 一类芳杂环化合物及其制备方法和应用

Family Cites Families (9)

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Publication number Priority date Publication date Assignee Title
PT79699B (en) * 1983-12-22 1986-12-10 Pfizer Process for preparing quinolone inotropic agents
GB8334282D0 (en) * 1983-12-22 1984-02-01 Pfizer Ltd Quinolone inotropic agents
CN85100796A (zh) * 1985-04-01 1986-10-01 辉瑞公司 喹啉酮衍生物的制备方法
FR2580646A1 (fr) * 1985-04-19 1986-10-24 Synthelabo Derives de 2(1h)-quinolinone, leur preparation et leur application en therapeutique
WO2006113432A2 (en) 2005-04-14 2006-10-26 Smithkline Beecham Corporation Compounds, compositions and methods
DE102008022221A1 (de) 2008-05-06 2009-11-12 Universität des Saarlandes Inhibitoren der humanen Aldosteronsynthase CYP11B2
EP2430018B1 (en) 2009-05-15 2013-07-03 Novartis AG Benzoxazolone derivatives as aldosterone symthase inhibitors
BRPI1010600A2 (pt) 2009-05-15 2016-03-15 Novartis Ag aril piridina como inibidores de aldosterona sintase
US8541404B2 (en) * 2009-11-09 2013-09-24 Elexopharm Gmbh Inhibitors of the human aldosterone synthase CYP11B2

Also Published As

Publication number Publication date
CL2014000604A1 (es) 2014-10-17
CA2846785C (en) 2020-09-22
MX358376B (es) 2018-08-16
MX2014002770A (es) 2014-06-05
MY169043A (en) 2019-02-07
TWI462914B (zh) 2014-12-01
HUE047771T2 (hu) 2020-05-28
CR20140091A (es) 2014-06-03
KR101785143B1 (ko) 2017-10-12
WO2013037779A1 (en) 2013-03-21
EP2755963B1 (en) 2019-10-30
EA201490596A1 (ru) 2014-07-30
AU2012307509A1 (en) 2014-03-13
IL231229A0 (en) 2014-04-30
AU2012307509B2 (en) 2017-06-29
LT2755963T (lt) 2020-01-27
PE20141372A1 (es) 2014-10-13
AR087901A1 (es) 2014-04-23
EA035757B1 (ru) 2020-08-05
HRP20192323T1 (hr) 2020-03-20
EP2755963A1 (en) 2014-07-23
CO6890099A2 (es) 2014-03-10
CN103814021A (zh) 2014-05-21
JP6012735B2 (ja) 2016-10-25
ES2763332T3 (es) 2020-05-28
PH12014500434A1 (en) 2017-04-19
PL2755963T3 (pl) 2020-07-27
TW201315724A (zh) 2013-04-16
JP2014527077A (ja) 2014-10-09
NZ621599A (en) 2016-07-29
EP3653618A1 (en) 2020-05-20
RS59737B1 (sr) 2020-02-28
DK2755963T3 (da) 2020-01-13
SI2755963T1 (sl) 2020-01-31
EP3653618B1 (en) 2025-01-08
CN103814021B (zh) 2016-12-21
US9260408B2 (en) 2016-02-16
ZA201401884B (en) 2019-11-27
ECSP14013245A (es) 2014-07-31
UA111626C2 (uk) 2016-05-25
BR112014006283A2 (pt) 2017-04-11
BR112014006283B1 (pt) 2021-11-03
US20130072679A1 (en) 2013-03-21
ES3016782T3 (en) 2025-05-09
CA2846785A1 (en) 2013-03-21
KR20140067121A (ko) 2014-06-03
PT2755963T (pt) 2020-01-10

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