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RU92016415A - Нейрозащитные производные индолона и родственные производные - Google Patents

Нейрозащитные производные индолона и родственные производные

Info

Publication number
RU92016415A
RU92016415A RU92016415/04A RU92016415A RU92016415A RU 92016415 A RU92016415 A RU 92016415A RU 92016415/04 A RU92016415/04 A RU 92016415/04A RU 92016415 A RU92016415 A RU 92016415A RU 92016415 A RU92016415 A RU 92016415A
Authority
RU
Russia
Prior art keywords
derivatives
indolon
neuro
protective
related derivatives
Prior art date
Application number
RU92016415/04A
Other languages
English (en)
Other versions
RU2068414C1 (ru
Inventor
Лео Ченард Бертранд
Original Assignee
Пфайзер Инк
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Пфайзер Инк filed Critical Пфайзер Инк
Priority claimed from PCT/US1991/001470 external-priority patent/WO1991017156A1/en
Publication of RU92016415A publication Critical patent/RU92016415A/ru
Application granted granted Critical
Publication of RU2068414C1 publication Critical patent/RU2068414C1/ru

Links

Claims (1)

  1. Предложены 5-(1-окси-2-пиперидинопропил)-2(1Н, 3Н)-индолоновые производные и аналоги, их фармацевтические композиции, способы лечения расстройств ЦНС с их помощью, интермедиаты, полезные при получении указанных соединений.
RU9192016415A 1990-05-10 1991-03-04 Производные индолона в виде рацемата или оптически активного изомера или их фармацевтически приемлемые аддитивные соли кислоты и кетопроизводные индолона RU2068414C1 (ru)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US52233290A 1990-05-10 1990-05-10
US522.332 1990-05-10
US522332 1990-05-10
PCT/US1991/001470 WO1991017156A1 (en) 1990-05-10 1991-03-04 Neuroprotective indolone and related derivatives

Publications (2)

Publication Number Publication Date
RU92016415A true RU92016415A (ru) 1995-08-20
RU2068414C1 RU2068414C1 (ru) 1996-10-27

Family

ID=24080448

Family Applications (1)

Application Number Title Priority Date Filing Date
RU9192016415A RU2068414C1 (ru) 1990-05-10 1991-03-04 Производные индолона в виде рацемата или оптически активного изомера или их фармацевтически приемлемые аддитивные соли кислоты и кетопроизводные индолона

Country Status (30)

Country Link
US (1) US5306723A (ru)
EP (1) EP0554247B1 (ru)
JP (1) JPH0699423B2 (ru)
KR (1) KR0163355B1 (ru)
CN (1) CN1037439C (ru)
AT (1) ATE192149T1 (ru)
AU (1) AU642994B2 (ru)
BR (1) BR9106432A (ru)
CA (1) CA2080475C (ru)
CZ (1) CZ280560B6 (ru)
DE (1) DE69132141T2 (ru)
DK (1) DK0554247T3 (ru)
EG (1) EG19647A (ru)
ES (1) ES2146578T3 (ru)
FI (1) FI109121B (ru)
GR (1) GR3034005T3 (ru)
HU (1) HU221193B1 (ru)
IE (1) IE911569A1 (ru)
IL (1) IL98056A (ru)
MY (1) MY107799A (ru)
NO (1) NO301979B1 (ru)
PH (1) PH29902A (ru)
PL (1) PL169267B1 (ru)
PT (1) PT97602B (ru)
RU (1) RU2068414C1 (ru)
SK (1) SK280833B6 (ru)
TW (1) TW198720B (ru)
WO (1) WO1991017156A1 (ru)
YU (1) YU48528B (ru)
ZA (1) ZA913494B (ru)

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GB9510459D0 (en) * 1995-05-24 1995-07-19 Zeneca Ltd Bicyclic amines
ZA9610741B (en) 1995-12-22 1997-06-24 Warner Lambert Co 4-Substituted piperidine analogs and their use as subtype selective nmda receptor antagonists
ZA9610736B (en) * 1995-12-22 1997-06-27 Warner Lambert Co 2-Substituted piperidine analogs and their use as subtypeselective nmda receptor antagonists
ZA9610738B (en) 1995-12-22 1997-06-24 Warner Lambert Co Subtype selective nmda receptor ligands and the use thereof
ZA9610745B (en) * 1995-12-22 1997-06-24 Warner Lambert Co 4-Subsituted piperidine analogs and their use as subtype selective nmda receptor antagonists
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AP9901538A0 (en) 1996-11-26 1999-06-30 Zeneca Ltd 8-Azabicyclo(3,2,1) octane-88-azabicycle(3,2,1) oct-6-ene-, 9- azabicycle(3,3,1) nonana-9-aza-3- oxabicylo(3,3,1) nonane-and 9-aza-3- thiabicyclo(3,3,1) nonane derivatives, their preparation and their use as insecticides.
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WO2000064422A2 (en) * 1999-04-27 2000-11-02 Smithkline Beecham P.L.C. Novel treatment of neurotraumatic conditions with raf inhibitor
US6291499B1 (en) 1999-10-29 2001-09-18 Merck & Co., Inc. 2-cyclohexyl benzimidazole NMDA/NR2B antagonists
US6369076B1 (en) 1999-10-29 2002-04-09 Merck & Co. Inc. 5-benzyl-octahydroindole and 6-benzyl-decahydroquinoline NMDA/NR2B antagonists
US6476041B1 (en) 1999-10-29 2002-11-05 Merck & Co., Inc. 1,4 substituted piperidinyl NMDA/NR2B antagonists
US6489477B1 (en) 1999-10-29 2002-12-03 Merck & Co., Inc. 2-aza-bicyclo[2.2.2]octane NMDA/NR2B antigonists
AU1153601A (en) 1999-10-29 2001-05-08 Merck Sharp & Dohme Limited Method to treat pain utilizing benzimidazole NMDA NR2B antagonists
US6495561B2 (en) 1999-10-29 2002-12-17 Merck & Co., Inc. 2-cyclohexyl imidazopyridine NMDA/NR2B antagonists
US6432976B1 (en) 1999-10-29 2002-08-13 Merck & Co., Inc. 8-aza-bicyclo[3.2.1]octane NMDA/NR2B antagonists
US6380205B1 (en) 1999-10-29 2002-04-30 Merck & Co., Inc. 2-cyclohexyl quinazoline NMDA/NR2B antagonists
US6316474B1 (en) 1999-10-29 2001-11-13 Merck & Co., Inc. 2-benzyl and 2-heteroaryl benzimidazole NMDA/NR2B antagonists
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WO2002080928A1 (en) * 2001-04-03 2002-10-17 Merck & Co., Inc. N-substituted nonaryl-heterocyclo amidyl nmda/nr2b antagonists
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