RU1826904C - Method for prophylaxis and treatment of bartonellosis at calves - Google Patents

Abstract

Using veterinary microbiology. SUMMARY OF THE INVENTION: Calves are given an antibiotic preparation comprising the following ratio of ingredients, wt.%: Diamidine 2-2.2; etonin 10-12; furatsilin 10-12; chloramphenicol 10-12 and 1-2% aqueous solution of Na-salt of carboxymethyl cellulose or 15-25% aqueous solution of polyvinylpyrrolidone else. The drug is administered at a dose of 1.5-2 ml

Description

The invention relates to the field of veterinary medicine and, in particular, relates to veterinary microbiology and epizootology.

The aim of the invention is to develop an effective method for the prevention of calf bartonellosis.

The essence of the invention lies in the fact that for this purpose thereafter immediately after birth, a suspension of the following composition is orally administered in the ratio, wt.%: Diamidine 2-2,2

Etonius, 10-12

Furacilin 10-12

Chloramphenicol 10-12

1-2% aqueous, carboxymethyl cellulose sodium salt solution or 15-25% polyvinylpyrrolidone solution - the rest is at a dose of 1.5-2 ml per 10 kg of calf live weight, and after 5-7 days the drug is administered once. Characteristics of drugs Furacilin - yellow or greenish-yellow powder of bitter taste. Very slightly soluble in water (1: 4,700). It is an antiseptic that acts on various gram-positive and gram-negative microbes (strepto-staphylococci, dysenteric, intestinal and paratyphoid bacilli and

DR-).

They are used externally for the treatment and prevention of purulent-inflammatory processes and orally for the treatment of bacterial dysentery, as well as gastrointestinal diseases of calves, pigs, chickens, and inflammation of the mucous membranes of the mouth, nose, pharynx, and vagina. The preparation is used in the form of a powder or aqueous suspension.

Carboxymethyl celluloses - an ether of cellulose and glucoconic acid, in the form of a free acid is insoluble in water; it dissolves in aqueous slightly alkaline solutions, forming viscous solutions of the sodium salt of carboxymethyl cellulose.

It is used in the production of detergents, petroleum pharmaceutical, textile, food and other industries.

Diamidine (imidocarb, imidozolin) - a new domestic drug synthesized in the VGNKI of veterinary drugs

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comrade it has a pronounced pyroplasmocidal effect and is used for the treatment and prevention of pyroplasmidoses of cattle and small cattle, as well as pyroplasmosis and horses ’nutrition.

Diamidine has a high therapeutic index of 8.

Chloramphenicol is a crystalline powder of white color, bitter taste, almost insoluble in water. Targeted inward is rapidly absorbed. It is bacteriostatic; therefore, it is prescribed within 3-7 days; excreted in urine.

It is used in acute gastrointestinal diseases of calves at doses of 0.02-0.03 mg / kg.

Etonium is a white crystalline powder with a specific odor. Easy to race

we create in water, alcohol.

It has a bacteriostatic and bactericidal effect, is effective against streptococci, staphylococci and other microorganisms. Stimulates wound healing.

They are used for trophic ulcers, nipple cracks, and rectum, for itchy dermatoses, stomatitis, gingivitis, corneal ulcers, keratitis, otitis media, etc.

Examples of the method.

As in many other farms, at the Boelet Oktbr state farm in the Dustlik district of the Jizzakh region, almost all nascent bodies are ill (in mild and severe) with bartonellosis or, as it is now called toxic dyspepsia with a high percentage of withdrawal.

For example, out of 35 bodies that migrated in May-June 1990, almost all became ill with bartonellosis. At the same time, 7 goals (20%) fell with the effects of toxic dyspepsia: profuse diarrhea, general depression, weakness, dehydration and death 3-5 days after birth. Those surviving bodies lagged behind in growth and development, most of which were subsequently ill with bronchopneumonia with a considerable amount of withdrawal.

For treatment and prophylaxis, vaccination of deep-skinned cows with a colibacteriosis vaccine was used, and after birth the antibiotics were introduced there (levomycin, tetracycline, streptomycin, neomycin, furozolidone, Lers, various physiological solutions, vitamins, etc.). However, their effectiveness was low.

For the prevention and treatment of bartonellosis by us, bodies there after the birth of the pen5

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the mixture (suspension) of the following composition was set in a ratio, wt.%:

Diamidine2

Ethony10

FuracilinTO

Chloramphenicol 10

1-2% solution of sodium carboxymethyl cellulose - the rest, which was used in doses:

1 ml (0.75-1.5 mg of diamidine per 1 kg of live weight);

1.5 ml (1.0-1.5 mg / kg);

2 ml (1.5-2 mg / kg);

3 ml (2-2.5 mg / kg);

4 ml (2.5-3 mg / kg);

5 ml (3.5-4 mg / kg);

6 ml (4-4.5 mg / kg);

7 ml (4; 5-5 mg / kg of diamidine per 1 kg of live weight).

In each group there were 10 bodies of t.

As a result, in the first group (1 ml of the drug) all the bodies became ill and then they were treated by giving the same drug in a dose of 5 ml, after which they recovered.

The same thing happened with doses of 1; 5 and 2 ml.

After giving the drug in a dose of 3 ml, 4 out of 10 calves fell ill (diarrhea) and had to give the drug again to all the bodies there in the same dose.

There was no waste of t.

After giving the drug in a dose of 4 ml, 2 out of 10 calves fell ill, they were also treated a second time in the same dosage.

All the bodies recovered.

After giving the drug in a dose of 5 ml, 2 calves also got sick, but they were not given the drug again, all the bodies recovered.

After giving the drug in a dose of 6 ml, 2 calves also got sick and they recovered without repeated intervention.

After giving the drug at a dose of 7 ml, diarrhea was not observed in the calves, but they had toxic effects, also after repeated use of the drug at a dose of 3-4 ml; salivation, restlessness, limb exaggeration, abdominal beating, limb convulsions. These symptoms were observed for 4-5 days, but there was no withdrawal.

Thus, the minimum dose is 2-2.5 mg of diamidine per 1 kg of live calf weight, the maximum is 4-4.5 mg / kg, and the optimum is 3.5-4.0 mg / kg in a mixture with ethonium. prolonged-release chloramphenicol and furatsilinom.

The use of the invention will most effectively prevent and treat nascent juvenile animals from bartonellosis. most dangerous

diseases in the neonatal period of development, which will make it possible to significantly increase the percentage of their safety with minimal labor and drugs, as well as prevent them from bronchopneumonia.

Claims (1)

SUMMARY OF THE INVENTION A method for the prophylaxis and treatment of calf bartonellosis, comprising administering antibiotics, characterized in that, in order to increase the effectiveness of the method, levomycetin and additionally diamidine, ethany, furatsillin and 1-2 are introduced therein % aqueous solution of sodium salt of carboxymethyl cellulose or 15-25% aqueous solution polyvinylpyrrolidone in the following ratio of ingredients, wt.%: 5 Diamidine 2.0-2.2 Etonius1 (M2 Furacilin 10-12 Chloramphenicol 10-12 101-2% aqueous solution sodium salt of carboxymethyl cellulose or a 15-25% aqueous solution of polyvinylpyrrolidone. The remaining 15 at a dose of 1.5-2.0 ml per 10 kg of calf live weight, and after 5-7 days, the drug is administered once.