PT3359541T - Pirazol[3,4-b]piridin-6-carboxamidas n-sulfoniladas e método de utilização - Google Patents

Pirazol[3,4-b]piridin-6-carboxamidas n-sulfoniladas e método de utilização

Info

Publication number: PT3359541T
Authority: PT; Portugal
Prior art keywords: sulfonylated; carboxamides; pyrazolo; pyridin; sulfonylated pyrazolo
Prior art date: 2015-10-09

Application number

PT167882323T

Other languages

English (en)

Original Assignee

Galapagos Nv

Abbvie Overseas Sarl

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2015-10-09

Filing date

2016-10-07

Publication date

2020-11-11

2016-10-07 Application filed by Galapagos Nv, Abbvie Overseas Sarl filed Critical Galapagos Nv

2020-11-11 Publication of PT3359541T publication Critical patent/PT3359541T/pt

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/501—Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/12—Mucolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/04—Artificial tears; Irrigation solutions
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Medicinal Chemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Epidemiology (AREA)
Neurology (AREA)
Pulmonology (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Physical Education & Sports Medicine (AREA)
Immunology (AREA)
Endocrinology (AREA)
Diabetes (AREA)
Urology & Nephrology (AREA)
Orthopedic Medicine & Surgery (AREA)
Psychology (AREA)
Hospice & Palliative Care (AREA)
Hematology (AREA)
Ophthalmology & Optometry (AREA)
Reproductive Health (AREA)
Psychiatry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

PT167882323T 2015-10-09 2016-10-07 Pirazol[3,4-b]piridin-6-carboxamidas n-sulfoniladas e método de utilização PT3359541T (pt)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US201562239647P	2015-10-09	2015-10-09
US201662309794P	2016-03-17	2016-03-17

Publications (1)

Publication Number	Publication Date
PT3359541T true PT3359541T (pt)	2020-11-11

Family

ID=57209654

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PT167882323T PT3359541T (pt)	2015-10-09	2016-10-07	Pirazol[3,4-b]piridin-6-carboxamidas n-sulfoniladas e método de utilização

Country Status (32)

Country	Link
US (4)	US9890158B2 (pt)
EP (1)	EP3359541B1 (pt)
JP (1)	JP6779992B2 (pt)
KR (1)	KR20180083323A (pt)
CN (1)	CN108513574B (pt)
AU (1)	AU2016333856C1 (pt)
BR (1)	BR112018007161B1 (pt)
CA (1)	CA3001096A1 (pt)
CL (1)	CL2018000911A1 (pt)
CO (1)	CO2018003716A2 (pt)
CR (1)	CR20180215A (pt)
CY (1)	CY1123545T1 (pt)
DK (1)	DK3359541T3 (pt)
EC (1)	ECSP18032223A (pt)
ES (1)	ES2829636T3 (pt)
HR (1)	HRP20201618T1 (pt)
HU (1)	HUE051067T2 (pt)
IL (1)	IL258553A (pt)
LT (1)	LT3359541T (pt)
MX (1)	MX2018004359A (pt)
NZ (1)	NZ741223A (pt)
PE (1)	PE20181348A1 (pt)
PH (1)	PH12018500765B1 (pt)
PL (1)	PL3359541T3 (pt)
PT (1)	PT3359541T (pt)
RU (1)	RU2724345C2 (pt)
SG (1)	SG11201802932VA (pt)
SI (1)	SI3359541T1 (pt)
TW (1)	TWI720032B (pt)
UY (1)	UY36943A (pt)
WO (1)	WO2017060874A1 (pt)
ZA (1)	ZA201802976B (pt)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
PT3359541T (pt) *	2015-10-09	2020-11-11	Galapagos Nv	Pirazol[3,4-b]piridin-6-carboxamidas n-sulfoniladas e método de utilização
US10138227B2 (en)	2016-06-03	2018-11-27	Abbvie S.Á.R.L.	Heteroaryl substituted pyridines and methods of use
US10399940B2 (en)	2016-10-07	2019-09-03	Abbvie S.Á.R.L.	Substituted pyrrolidines and methods of use
US9981910B2 (en)	2016-10-07	2018-05-29	Abbvie S.Á.R.L.	Substituted pyrrolidines and methods of use
US20200123137A1 (en)	2016-12-20	2020-04-23	AbbVie S.à.r.l.	Deuterated cftr modulators and methods of use
TW201831471A (zh)	2017-02-24	2018-09-01	盧森堡商艾伯維公司	囊腫纖化症跨膜傳導調節蛋白的調節劑及其使用方法
US10988454B2 (en) *	2017-09-14	2021-04-27	Abbvie Overseas S.À.R.L.	Modulators of the cystic fibrosis transmembrane conductance regulator protein and methods of use
WO2019193062A1 (en)	2018-04-03	2019-10-10	Abbvie S.Á.R.L	Substituted pyrrolidines and their use
GB201905711D0 (en) *	2019-04-24	2019-06-05	Galapagos Nv	Novel compounds and pharmaceutical compositions thereof for the treatment of kidney diseases
US11345691B2 (en)	2019-06-03	2022-05-31	AbbVie Global Enterprises Ltd.	Prodrug modulators of the cystic fibrosis transmembrane conductance regulator protein and methods of use
US20220267300A1 (en) *	2019-06-12	2022-08-25	NodThera Limited	Sulfonamide derivatives and uses thereof
US11236067B2 (en)	2019-07-12	2022-02-01	Orphomed, Inc.	Compound for treating cystic fibrosis
MX2022006783A (es)	2019-12-10	2022-07-11	Hoffmann La Roche	Nuevos derivados de metilquinazolinona.
CN115843272A (zh)	2020-05-08	2023-03-24	哈利亚治疗公司	Nek7激酶的抑制剂
WO2021252488A1 (en)	2020-06-08	2021-12-16	Halia Therapeutics, Inc.	Inhibitors of nek7 kinase
CR20230120A (es)	2020-08-07	2023-09-01	Vertex Pharma	Moduladores del regulador de la conductancia transmembrana de la fibrosis quística
EP4199914A4 (en)	2020-08-20	2024-09-04	Univ Leland Stanford Junior	METHODS OF TREATMENT OF RESPIRATORY DISEASES CHARACTERIZED BY HYPERSECRETION OF MUCUS
WO2022150173A1 (en)	2021-01-06	2022-07-14	AbbVie Global Enterprises Ltd.	Modulators of the cystic fibrosis transmembrane conductance regulator protein and methods of use
EP4274828A1 (en)	2021-01-06	2023-11-15	AbbVie Global Enterprises Ltd.	Modulators of the cystic fibrosis transmembrane conductance regulator protein and methods of use
IL314691A (en)	2022-02-03	2024-10-01	Vertex Pharma	PREPARATION METHODS AND CRYSTALLINE FORMS OF (6A,12A)-17-AMINO-12-METHYL-6,15-BIS(TRIFLUOROMETHYL)-13,19-DIOXA-3,4,18-TRIAZATRICYCLO[ 12.3.112.3.1. NONADECA-1(18),2,4,14,16-PENTAEN-6-OL
IL314449A (en)	2022-02-03	2024-09-01	Vertex Pharma	Cystic fibrosis treatment methods
WO2023154291A1 (en)	2022-02-08	2023-08-17	Vertex Pharmaceuticals Incorporated	Modulators of cystic fibrosis transmembrane conductance regulator
WO2023224931A1 (en)	2022-05-16	2023-11-23	Vertex Pharmaceuticals Incorporated	Methods of treatment for cystic fibrosis
CN115806532A (zh) *	2022-08-31	2023-03-17	大连百傲化学股份有限公司	一种mit中杂质的制备方法
US20240158394A1 (en)	2022-09-14	2024-05-16	Halia Therapeutics, Inc.	Nek7 inhibitors
CN115960100B (zh) *	2022-12-28	2023-08-18	北京康立生医药技术开发有限公司	一种治疗胃肠道间质瘤药物皮咪特昔布的合成方法

Family Cites Families (34)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3833598A (en) *	1972-12-29	1974-09-03	Squibb & Sons Inc	Amino derivatives of pyrazolopyridine-6-carboxylic acids and esters
GB0217431D0 (en)	2002-07-27	2002-09-04	Astrazeneca Ab	Novel compounds
WO2005090354A1 (en) *	2004-03-16	2005-09-29	Glaxo Group Limited	PYRAZOLO[3,4-b] PYRIDINE COMPOUNDS, AND THEIR USE AS PDE4 INHIBITORS
US7939558B2 (en)	2004-06-04	2011-05-10	The Regents Of The University Of California	Compounds having activity in increasing ion transport by mutant-CFTR and uses thereof
US8354427B2 (en)	2004-06-24	2013-01-15	Vertex Pharmaceutical Incorporated	Modulators of ATP-binding cassette transporters
CN101006076B (zh)	2004-06-24	2010-09-29	沃泰克斯药物股份有限公司	Atp-结合弹夹转运蛋白的调控剂
MXPA06014699A (es) *	2004-07-05	2007-03-26	Astellas Pharma Inc	Derivados de pirazolo-piridina.
US8362031B2 (en)	2004-08-20	2013-01-29	University Of Kansas	Lonidamine analogues and treatment of polycystic kidney disease
CN101687883B (zh)	2007-05-25	2012-05-23	沃泰克斯药物股份有限公司	囊性纤维化跨膜传导调节因子的调节剂
WO2009062118A2 (en) *	2007-11-07	2009-05-14	Foldrx Pharmaceuticals, Inc.	Modulation of protein trafficking
PE20091096A1 (es)	2007-12-10	2009-08-25	Novartis Ag	Compuestos organicos
JP5637859B2 (ja)	2007-12-13	2014-12-10	バーテックスファーマシューティカルズインコーポレイテッドＶｅｒｔｅｘＰｈａｒｍａｃｅｕｔｉｃａｌｓＩｎｃｏｒｐｏｒａｔｅｄ	嚢胞性線維症膜コンダクタンスレギュレーターのモジュレーター
AU2009308241B2 (en)	2008-10-23	2016-01-07	Vertex Pharmaceuticals Incorporated	Solid forms of N-(4-(7-azabicyclo[2.2.1]heptan-7-yl)-2-(trifluoromethyl) phenyl)-4-oxo-5-(trifluoromethyl)-1,4-dihydroquinoline-3-carboxamide
JP5699090B2 (ja)	2008-12-30	2015-04-08	バーテックスファーマシューティカルズインコーポレイテッドＶｅｒｔｅｘＰｈａｒｍａｃｅｕｔｉｃａｌｓＩｎｃｏｒｐｏｒａｔｅｄ	嚢胞性線維症膜コンダクタンス調節因子のモジュレーター
US8247436B2 (en)	2010-03-19	2012-08-21	Novartis Ag	Pyridine and pyrazine derivative for the treatment of CF
CA2811265C (en) *	2010-09-14	2018-07-31	Instytut Biochemii I Biofizyki Pan	Compounds as modulators of a mutant cftr protein and their use for treating diseases associated with cftr protein malfunction
BR112013007907A2 (pt)	2010-10-08	2016-06-14	N30 Pharmaceuticals Inc	novos compostos de quinolina substituída como inibidores de s-nitrosoglutationa reductase
WO2013038390A1 (en)	2011-09-16	2013-03-21	Novartis Ag	N-substituted heterocyclyl carboxamides
US9034879B2 (en)	2011-09-16	2015-05-19	Novartis Ag	Heterocyclic compounds for the treatment of CF
WO2013038381A1 (en)	2011-09-16	2013-03-21	Novartis Ag	Pyridine/pyrazine amide derivatives
WO2013038378A1 (en)	2011-09-16	2013-03-21	Novartis Ag	Pyridine amide derivatives
WO2013038373A1 (en)	2011-09-16	2013-03-21	Novartis Ag	Pyridine amide derivatives
US9127040B2 (en)	2011-09-20	2015-09-08	The University Of North Carolina At Chapel Hill	Regulation of sodium channels by PLUNC proteins
CA2853439A1 (en) *	2011-10-31	2013-05-10	Xenon Pharmaceuticals Inc.	Benzenesulfonamide compounds and their use as therapeutic agents
WO2014081820A1 (en) *	2012-11-20	2014-05-30	Discoverybiomed, Inc.	Small molecule cftr correctors
LU92578B1 (fr)	2013-05-07	2014-12-15	Galapagos Nv	Nouveaux composés et compostions pharmaceutiques de ceux-ci pour le traitement de la mucoviscidose
RU2708690C2 (ru)	2013-08-08	2019-12-11	Галапагос Нв	Производные тиено[2,3-c]пиранов в качестве cftr модуляторов
SG11201606367YA (en) *	2014-02-06	2016-09-29	Abbvie Inc	6-heteroaryloxy- and 6-aryloxy-quinoline-2-carboxamides and uses thereof
WO2015138934A1 (en)	2014-03-13	2015-09-17	Proteostasis Therapeutics, Inc.	Compounds, compositions, and methods for increasing cftr activity
EP3116501A1 (en)	2014-03-13	2017-01-18	Proteostasis Therapeutics, Inc.	Compounds, compositions, and methods for increasing cftr activity
JP6676646B2 (ja)	2014-10-31	2020-04-08	アッヴィ・エス・ア・エール・エル	置換クロマンおよび使用方法
US9567322B2 (en)	2014-10-31	2017-02-14	Abbvie S.Á.R.L.	Substituted tetrahydropyrans and method of use
BR112018007165A2 (pt) *	2015-10-09	2019-01-22	AbbVie S.à.r.l.	novos compostos para tratamento da fibrose cística
PT3359541T (pt) *	2015-10-09	2020-11-11	Galapagos Nv	Pirazol[3,4-b]piridin-6-carboxamidas n-sulfoniladas e método de utilização

2016
- 2016-10-07 PT PT167882323T patent/PT3359541T/pt unknown
- 2016-10-07 CA CA3001096A patent/CA3001096A1/en active Pending
- 2016-10-07 DK DK16788232.3T patent/DK3359541T3/da active
- 2016-10-07 WO PCT/IB2016/056029 patent/WO2017060874A1/en active Application Filing
- 2016-10-07 US US15/287,911 patent/US9890158B2/en active Active
- 2016-10-07 BR BR112018007161-7A patent/BR112018007161B1/pt active IP Right Grant
- 2016-10-07 JP JP2018517444A patent/JP6779992B2/ja active Active
- 2016-10-07 TW TW105132676A patent/TWI720032B/zh active
- 2016-10-07 SG SG11201802932VA patent/SG11201802932VA/en unknown
- 2016-10-07 PL PL16788232T patent/PL3359541T3/pl unknown
- 2016-10-07 RU RU2018115722A patent/RU2724345C2/ru active
- 2016-10-07 LT LTEP16788232.3T patent/LT3359541T/lt unknown
- 2016-10-07 HU HUE16788232A patent/HUE051067T2/hu unknown
- 2016-10-07 PE PE2018000521A patent/PE20181348A1/es unknown
- 2016-10-07 EP EP16788232.3A patent/EP3359541B1/en active Active
- 2016-10-07 MX MX2018004359A patent/MX2018004359A/es unknown
- 2016-10-07 AU AU2016333856A patent/AU2016333856C1/en active Active
- 2016-10-07 CN CN201680069459.4A patent/CN108513574B/zh active Active
- 2016-10-07 ES ES16788232T patent/ES2829636T3/es active Active
- 2016-10-07 NZ NZ741223A patent/NZ741223A/en unknown
- 2016-10-07 KR KR1020187012937A patent/KR20180083323A/ko not_active Application Discontinuation
- 2016-10-07 SI SI201630965T patent/SI3359541T1/sl unknown
- 2016-10-07 CR CR20180215A patent/CR20180215A/es unknown
- 2016-10-11 UY UY0001036943A patent/UY36943A/es not_active Application Discontinuation
2017
- 2017-12-15 US US15/843,917 patent/US10259810B2/en active Active
2018
- 2018-04-06 CO CONC2018/0003716A patent/CO2018003716A2/es unknown
- 2018-04-06 PH PH12018500765A patent/PH12018500765B1/en unknown
- 2018-04-08 IL IL258553A patent/IL258553A/en active IP Right Grant
- 2018-04-09 CL CL2018000911A patent/CL2018000911A1/es unknown
- 2018-04-26 EC ECIEPI201832223A patent/ECSP18032223A/es unknown
- 2018-05-07 ZA ZA2018/02976A patent/ZA201802976B/en unknown
2019
- 2019-03-06 US US16/293,973 patent/US20190202823A1/en not_active Abandoned
- 2019-06-18 US US16/444,495 patent/US10647717B2/en active Active
2020
- 2020-10-08 HR HRP20201618TT patent/HRP20201618T1/hr unknown
- 2020-11-03 CY CY20201101034T patent/CY1123545T1/el unknown

Also Published As

Publication number	Publication date
WO2017060874A1 (en)	2017-04-13
ECSP18032223A (es)	2018-05-31
EP3359541A1 (en)	2018-08-15
HRP20201618T1 (hr)	2020-12-25
KR20180083323A (ko)	2018-07-20
BR112018007161A2 (pt)	2018-10-30
RU2018115722A (ru)	2019-11-12
US10647717B2 (en)	2020-05-12
TW201722948A (zh)	2017-07-01
IL258553A (en)	2018-05-31
US20170101405A1 (en)	2017-04-13
PH12018500765A1 (en)	2018-10-01
JP6779992B2 (ja)	2020-11-04
JP2018529743A (ja)	2018-10-11
CA3001096A1 (en)	2017-04-13
ES2829636T3 (es)	2021-06-01
PE20181348A1 (es)	2018-08-22
US20190202823A1 (en)	2019-07-04
CY1123545T1 (el)	2022-03-24
UY36943A (es)	2017-05-31
CO2018003716A2 (es)	2018-07-19
LT3359541T (lt)	2020-11-25
CL2018000911A1 (es)	2018-08-24
MX2018004359A (es)	2018-05-01
BR112018007161B1 (pt)	2024-01-16
US20180105522A1 (en)	2018-04-19
PH12018500765B1 (en)	2018-10-01
HUE051067T2 (hu)	2021-01-28
CN108513574B (zh)	2021-01-05
US10259810B2 (en)	2019-04-16
DK3359541T3 (da)	2020-11-09
CR20180215A (es)	2018-06-05
SG11201802932VA (en)	2018-05-30
AU2016333856B2 (en)	2021-05-20
NZ741223A (en)	2023-03-31
ZA201802976B (en)	2019-07-31
EP3359541B1 (en)	2020-08-05
US9890158B2 (en)	2018-02-13
RU2018115722A3 (pt)	2020-02-18
AU2016333856C1 (en)	2021-12-09
AU2016333856A1 (en)	2018-04-26
TWI720032B (zh)	2021-03-01
US20190330207A1 (en)	2019-10-31
PL3359541T3 (pl)	2021-01-11
CN108513574A (zh)	2018-09-07
RU2724345C2 (ru)	2020-06-23
SI3359541T1 (sl)	2021-01-29

Publication	Publication Date	Title
ZA201802976B (en)	2019-07-31	N-sulfonylated pyrazolo[3,4-b]pyridin-6-carboxamides and method of use
HK1254358A1 (zh)	2019-07-19	用於治療突觸核蛋白病的藥劑、用途和方法
IL266596A (en)	2019-07-31	Causes, uses and methods of treating synovialitis
HK1244804A1 (zh)	2018-08-17	4h-吡咯並[3，2-c]吡啶-4-酮衍生物
HK1232140A1 (zh)	2018-01-05	微類器官以及製造和使用它們的方法
SI3674302T1 (sl)	2023-07-31	1h-pirolo(2,3-c)piridin-7(6h)-oni in pirazolo(3,4-c)piridin-7(6h)-oni kot zaviralci proteinov bet
IL251164B (en)	2020-10-29	Imidazo[4,5–c]pyridine derivatives as inhibitors of ssao
ZA201808257B (en)	2020-05-27	1h-pyrazolo[4,3-b]pyridines as pde1 inhibitors
HK1225723A1 (zh)	2017-09-15	取代的咪唑並[1，2-a]吡啶甲酰胺及其用途
PL3373910T3 (pl)	2023-10-09	Preparat echinomycyny, sposób wytwarzania i sposób stosowania
SG11201803485UA (en)	2018-05-30	Method for producing silazane-siloxane copolymers and the use of such copolymers
IL251166A0 (en)	2017-04-30	Imidazo-[4,5-c]pyridine derivatives as inhibitors of ssao
SG11201610266RA (en)	2017-04-27	Choux pastry and method for producing the same
HUE058909T2 (hu)	2022-09-28	Etomidátszármazék és köztitermék, eljárás elõállítására és alkalmazása
GB201802644D0 (en)	2018-04-04	Monocyclic,thieno, pyrido and pyrrolo pyrimidine compounds and methods of use and manufacture of the same
EP3381921A4 (en)	2019-10-30	GINKGOLIDE B DERIVATIVE AND METHOD OF PREPARING THEREOF AND USE THEREOF
ZA201704727B (en)	2021-05-26	New imidazo[1,2-a]quinoxalines and derivates thereof for the treatment of cancer
GB201601047D0 (en)	2016-03-02	New process, use and method
HK1206334A1 (en)	2016-01-08	Dehydrothiamine [2,3-c]quinoline-12-ketone derivatives, and preparation method and application thereof [2,3-c]-12-
IL235077A0 (en)	2015-02-01	New derivatives of thiochromano[2,3-c]quino lin-12-one, its preparation method and application
SG10201406318YA (en)	2016-05-30	Novel thiochromeno[2,3-c]quinolin-12-one derivatives, preparation method and application thereof