PL3227297T3 - 4,6 podstawione-pyrazolo[1,5-a]pirazyny jako inhibitory kinaz janusowych - Google Patents

4,6 podstawione-pyrazolo[1,5-a]pirazyny jako inhibitory kinaz janusowych

Info

Publication number: PL3227297T3
Authority: PL; Poland
Prior art keywords: pyrazines; pyrazolo; substituted; kinase inhibitors; janus kinase
Prior art date: 2014-12-05

Application number

PL15819933T

Other languages

English (en)

Inventor

Shelley Allen

Mark Laurence Boys

Mark J. CHICARELLI

Jay Bradford Fell

John P. Fischer

John Gaudino

Erik James Hicken

Ronald Jay Hinklin

Christopher F. Kraser

Ellen Laird

John E. Robinson

Tony P. Tang

Laurence E. Burgess

Robert Andrew RIEGER

Jed Pheneger

Yoshitaka Satoh

Katerina Leftheris

Raj K. Raheja

Brydon L. Bennett

Original Assignee

Array Biopharma, Inc.

Celgene Corporation

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2014-12-05

Filing date

2015-12-04

Publication date

2021-10-25

2015-12-04 Application filed by Array Biopharma, Inc., Celgene Corporation filed Critical Array Biopharma, Inc.

2021-10-25 Publication of PL3227297T3 publication Critical patent/PL3227297T3/pl

Classifications

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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
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- A—HUMAN NECESSITIES
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- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Epidemiology (AREA)
Immunology (AREA)
Diabetes (AREA)
Rheumatology (AREA)
Hematology (AREA)
Physical Education & Sports Medicine (AREA)
Pain & Pain Management (AREA)
Obesity (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Pulmonology (AREA)
Orthopedic Medicine & Surgery (AREA)
Dermatology (AREA)
Transplantation (AREA)
Endocrinology (AREA)
Ophthalmology & Optometry (AREA)
Psychiatry (AREA)
Child & Adolescent Psychology (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Hospice & Palliative Care (AREA)
Biochemistry (AREA)
Molecular Biology (AREA)
Emergency Medicine (AREA)

PL15819933T 2014-12-05 2015-12-04 4,6 podstawione-pyrazolo[1,5-a]pirazyny jako inhibitory kinaz janusowych PL3227297T3 (pl)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US201462088068P	2014-12-05	2014-12-05
EP15819933.1A EP3227297B1 (en)	2014-12-05	2015-12-04	4,6-substituted-pyrazolo[1,5-a]pyrazines as janus kinase inhibitors
PCT/US2015/064062 WO2016090285A1 (en)	2014-12-05	2015-12-04	4,6-SUBSTITUTED-PYRAZOLO[1,5-a]PYRAZINES AS JANUS KINASE INHIBITORS

Publications (1)

Publication Number	Publication Date
PL3227297T3 true PL3227297T3 (pl)	2021-10-25

Family

ID=55069089

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PL15819933T PL3227297T3 (pl)	2014-12-05	2015-12-04	4,6 podstawione-pyrazolo[1,5-a]pirazyny jako inhibitory kinaz janusowych

Country Status (29)

Country	Link
US (3)	US10189845B2 (pl)
EP (2)	EP3878451A1 (pl)
JP (2)	JP6641373B2 (pl)
KR (1)	KR20170090476A (pl)
CN (1)	CN107278203B (pl)
AU (1)	AU2015357585B2 (pl)
BR (1)	BR112017011798A2 (pl)
CA (1)	CA2969709A1 (pl)
CL (1)	CL2017001422A1 (pl)
CO (1)	CO2017006674A2 (pl)
CR (1)	CR20170309A (pl)
DK (1)	DK3227297T3 (pl)
ES (1)	ES2865483T3 (pl)
HR (1)	HRP20210501T1 (pl)
HU (1)	HUE054371T2 (pl)
IL (1)	IL252656A0 (pl)
MX (1)	MX386316B (pl)
MY (1)	MY191016A (pl)
PH (1)	PH12017501032A1 (pl)
PL (1)	PL3227297T3 (pl)
PT (1)	PT3227297T (pl)
RS (1)	RS61693B1 (pl)
RU (2)	RU2021102805A (pl)
SG (1)	SG11201704542SA (pl)
SI (1)	SI3227297T1 (pl)
TW (1)	TWI725004B (pl)
UA (1)	UA120065C2 (pl)
WO (1)	WO2016090285A1 (pl)
ZA (1)	ZA201704494B (pl)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2017156493A1 (en)	2016-03-11	2017-09-14	Denali Therapeutics Inc.	Compounds, compositions, and methods
EP3878451A1 (en)	2014-12-05	2021-09-15	Array Biopharma Inc.	Pharmaceutical composition comprising a jak-inhibiting 4,6-substituted-pyrazolo[1,5-a]pyrazine compound
GEP20217242B (en)	2016-02-24	2021-04-12	Pfizer	Pyrazolo[1,5-a]pyrazin-4-yl derivatives as jak-inhibitors
IL263484B2 (en)	2016-06-16	2024-02-01	Denali Therapeutics Inc	Pyrimidin-2-ylamino-1h-pyrazols as lrrk2 inhibitors for use in the treatment of neurodegenerative disorders
GB201617758D0 (en) *	2016-10-20	2016-12-07	Almac Discovery Limited	Pharmaceutical compounds
ES2948194T3 (es)	2017-01-18	2023-09-01	Array Biopharma Inc	Compuestos de pirazolo[1,5-a]pirazina sustituida como inhibidores de la cinasa RET
US20200157081A1 (en) *	2017-05-24	2020-05-21	Denali Therapeutics Inc.	Compounds, compositions and methods
US11254668B2 (en)	2017-08-14	2022-02-22	Pfizer Inc.	Pyrazolo[1,5-A]pyrazin-4-yl and related derivatives
CN111630054B (zh)	2018-01-18	2023-05-09	奥瑞生物药品公司	作为RET激酶抑制剂的取代的吡唑并[3,4-d]嘧啶化合物
US11603374B2 (en)	2018-01-18	2023-03-14	Array Biopharma Inc.	Substituted pyrrolo[2,3-d]pyrimidines compounds as ret kinase inhibitors
US11472802B2 (en)	2018-01-18	2022-10-18	Array Biopharma Inc.	Substituted pyrazolyl[4,3-c]pyridine compounds as RET kinase inhibitors
US11964988B2 (en)	2018-09-10	2024-04-23	Array Biopharma Inc.	Fused heterocyclic compounds as RET kinase inhibitors
JP7256291B2 (ja) *	2019-04-12	2023-04-11	プライムジーン（ベイジン）カンパニーリミテッド	ピラゾロピラジン誘導の化合物、医薬組成物およびその使用
BR112021022682A2 (pt)	2019-05-14	2022-02-22	Provention Bio Inc	Métodos e composições para prevenir diabetes do tipo 1
CN113150012B (zh) *	2020-01-22	2023-03-24	浙江海正药业股份有限公司	吡唑并[1,5-a]吡嗪类衍生物及其制备方法和用途
KR20220164008A (ko)	2020-04-04	2022-12-12	화이자 인코포레이티드	코로나바이러스 질환 2019를 치료하는 방법
KR20230092863A (ko)	2020-06-11	2023-06-26	프로벤션 바이오, 인코포레이티드	제1형 당뇨병을 예방하기 위한 방법 및 조성물
IL312782A (en) *	2021-11-12	2024-07-01	Soter Biopharma Pte Ltd	Pyrazolo fused ring compound and use thereof
WO2024235167A1 (zh) *	2023-05-12	2024-11-21	海南康哲美丽科技有限公司	一种吡唑并吡嗪类化合物及其晶型的制备方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ATE292121T1 (de)	1998-08-21	2005-04-15	Parker Hughes Inst	Chinazolinderivate
DE102007032349A1 (de) *	2007-07-11	2009-01-15	Bayer Healthcare Ag	Imidazo-, Pyrazolopyrazine und Imidazotriazine und ihre Verwendung
US8440689B2 (en)	2009-12-23	2013-05-14	Takeda Pharmaceutical Company Limited	Fused heteroaromatic pyrrolidinones
WO2011089400A1 (en) *	2010-01-22	2011-07-28	Centro Nacional De Investigaciones Oncológicas (Cnio)	Inhibitors of pi3 kinase
UY33213A (es) *	2010-02-18	2011-09-30	Almirall Sa	Derivados de pirazol como inhibidores de jak
US20110241987A1 (en) *	2010-04-01	2011-10-06	Smart Technologies Ulc	Interactive input system and information input method therefor
UA109131C2 (ru) *	2010-04-14	2015-07-27	Еррей Біофарма Інк.	5,7-ЗАМЕЩЕННЫЕ ИМИДАЗО[1,2-c]ПИРИМИДИНЫ КАК ИНГИБИТОРЫ JAK-КИНАЗ
CN103987713A (zh) *	2011-10-12	2014-08-13	阵列生物制药公司	5,7-取代的咪唑并[1,2-c]嘧啶
SI2831077T1 (sl) *	2012-03-28	2016-09-30	Merck Patent Gmbh	Biciklični pirazinonski derivati
EP3878451A1 (en)	2014-12-05	2021-09-15	Array Biopharma Inc.	Pharmaceutical composition comprising a jak-inhibiting 4,6-substituted-pyrazolo[1,5-a]pyrazine compound

2015
- 2015-12-04 EP EP21152373.3A patent/EP3878451A1/en not_active Withdrawn
- 2015-12-04 CR CR20170309A patent/CR20170309A/es unknown
- 2015-12-04 KR KR1020177018122A patent/KR20170090476A/ko not_active Withdrawn
- 2015-12-04 HR HRP20210501TT patent/HRP20210501T1/hr unknown
- 2015-12-04 DK DK15819933.1T patent/DK3227297T3/da active
- 2015-12-04 US US15/532,937 patent/US10189845B2/en active Active
- 2015-12-04 UA UAA201707008A patent/UA120065C2/uk unknown
- 2015-12-04 TW TW104140878A patent/TWI725004B/zh not_active IP Right Cessation
- 2015-12-04 CA CA2969709A patent/CA2969709A1/en not_active Abandoned
- 2015-12-04 PT PT158199331T patent/PT3227297T/pt unknown
- 2015-12-04 ES ES15819933T patent/ES2865483T3/es active Active
- 2015-12-04 RU RU2021102805A patent/RU2021102805A/ru unknown
- 2015-12-04 SI SI201531544T patent/SI3227297T1/sl unknown
- 2015-12-04 WO PCT/US2015/064062 patent/WO2016090285A1/en active Application Filing
- 2015-12-04 EP EP15819933.1A patent/EP3227297B1/en active Active
- 2015-12-04 RS RS20210415A patent/RS61693B1/sr unknown
- 2015-12-04 AU AU2015357585A patent/AU2015357585B2/en not_active Ceased
- 2015-12-04 PL PL15819933T patent/PL3227297T3/pl unknown
- 2015-12-04 CN CN201580066136.5A patent/CN107278203B/zh not_active Expired - Fee Related
- 2015-12-04 JP JP2017529681A patent/JP6641373B2/ja not_active Expired - Fee Related
- 2015-12-04 BR BR112017011798A patent/BR112017011798A2/pt not_active IP Right Cessation
- 2015-12-04 MY MYPI2017702034A patent/MY191016A/en unknown
- 2015-12-04 SG SG11201704542SA patent/SG11201704542SA/en unknown
- 2015-12-04 HU HUE15819933A patent/HUE054371T2/hu unknown
- 2015-12-04 RU RU2017123387A patent/RU2742938C2/ru active
- 2015-12-04 MX MX2017007284A patent/MX386316B/es unknown
2017
- 2017-06-02 PH PH12017501032A patent/PH12017501032A1/en unknown
- 2017-06-04 IL IL252656A patent/IL252656A0/en active IP Right Grant
- 2017-06-05 CL CL2017001422A patent/CL2017001422A1/es unknown
- 2017-06-30 CO CONC2017/0006674A patent/CO2017006674A2/es unknown
- 2017-07-03 ZA ZA2017/04494A patent/ZA201704494B/en unknown
2018
- 2018-12-06 US US16/212,493 patent/US10730880B2/en active Active
2019
- 2019-12-11 JP JP2019223760A patent/JP2020055859A/ja active Pending
2020
- 2020-06-02 US US16/890,663 patent/US11028093B2/en active Active

Also Published As

Publication number	Publication date
UA120065C2 (uk)	2019-09-25
WO2016090285A1 (en)	2016-06-09
RU2017123387A3 (pl)	2019-06-03
SI3227297T1 (sl)	2021-04-30
JP6641373B2 (ja)	2020-02-05
US10189845B2 (en)	2019-01-29
US20190177328A1 (en)	2019-06-13
MX2017007284A (es)	2017-08-25
CN107278203A (zh)	2017-10-20
EP3227297A1 (en)	2017-10-11
EP3227297B1 (en)	2021-01-20
TWI725004B (zh)	2021-04-21
RU2742938C2 (ru)	2021-02-11
RU2021102805A (ru)	2021-02-12
US11028093B2 (en)	2021-06-08
MY191016A (en)	2022-05-28
TW201632523A (zh)	2016-09-16
JP2018507167A (ja)	2018-03-15
IL252656A0 (en)	2017-07-31
RU2017123387A (ru)	2019-01-11
CR20170309A (es)	2018-02-02
HUE054371T2 (hu)	2021-09-28
ZA201704494B (en)	2022-03-30
CN107278203B (zh)	2020-05-19
ES2865483T3 (es)	2021-10-15
PH12017501032A1 (en)	2017-11-27
US20170362240A1 (en)	2017-12-21
CL2017001422A1 (es)	2018-01-05
PT3227297T (pt)	2021-04-09
KR20170090476A (ko)	2017-08-07
EP3878451A1 (en)	2021-09-15
JP2020055859A (ja)	2020-04-09
US10730880B2 (en)	2020-08-04
DK3227297T3 (da)	2021-04-06
SG11201704542SA (en)	2017-07-28
CO2017006674A2 (es)	2017-10-20
HRP20210501T1 (hr)	2021-05-14
US20200291039A1 (en)	2020-09-17
BR112017011798A2 (pt)	2017-12-26
AU2015357585B2 (en)	2020-07-02
RS61693B1 (sr)	2021-05-31
MX386316B (es)	2025-03-18
AU2015357585A1 (en)	2017-07-13
CA2969709A1 (en)	2016-06-09

Publication	Publication Date	Title
ZA201704494B (en)	2022-03-30	4,6-substituted-pyrazolo[1,5-a]pyrazines as janus kinase inhibitors
IL277576A (en)	2020-11-30	Mutated pyrazolo[1,5-A]pyridine compounds as RET kinase inhibitors
IL265918B (en)	2021-01-31	Converted pyrazolo[1,5–a]pyridine compounds as ret kinase inhibitors
ZA201800771B (en)	2021-05-26	Substituted pyrazolo[1,5-a]pyridine compounds as ret kinase inhibitors
ZA201901034B (en)	2021-06-30	Macrocycle kinase inhibitors
ZA201808431B (en)	2020-05-27	Pyrazolopyrimidine derivatives as kinase inhibitor
IL254224A0 (en)	2017-10-31	7-substituted 5-alkyl-[4,2,1]triazolo[5,1-a]pyrimidine derivatives as pde2 inhibitors
IL252053A0 (en)	2017-07-31	Substituted pyrazolo(1,5-a)pyrimidines and their use in the treatment of medical disorders
PT3305788T (pt)	2020-09-25	Inibidor da janus cinase
PL3555074T3 (pl)	2022-11-07	Aminopirazole jako selektywne inhibitory kinaz janusowych
EP3209296A4 (en)	2018-04-11	Ethyl n-boc piperidinyl pyrazolo pyridones as janus kinase inhibitors
IL290419A (en)	2022-04-01	Imidazo[a-1,5]pyrazine derivatives as inhibitors of pi3k delta
IL252986B (en)	2019-11-28	5,3-diaminopyrazole kinase inhibitors
HK1238236A1 (en)	2018-04-27	4,6-substituted-pyrazolo[1,5-a]pyrazines as janus kinase inhibitors
GB201613945D0 (en)	2016-09-28	Compounds useful as kinase inhibitors