PL2194987T3 - Nowe inhibitory szlaku białka stat3 oraz inhibitorów nowotworowych komórek macierzystych - Google Patents
Nowe inhibitory szlaku białka stat3 oraz inhibitorów nowotworowych komórek macierzystychInfo
- Publication number
- PL2194987T3 PL2194987T3 PL08830471T PL08830471T PL2194987T3 PL 2194987 T3 PL2194987 T3 PL 2194987T3 PL 08830471 T PL08830471 T PL 08830471T PL 08830471 T PL08830471 T PL 08830471T PL 2194987 T3 PL2194987 T3 PL 2194987T3
- Authority
- PL
- Poland
- Prior art keywords
- inhibitors
- stem cell
- cancer stem
- stat3 pathway
- novel stat3
- Prior art date
Links
- 239000003112 inhibitor Substances 0.000 title 2
- 206010028980 Neoplasm Diseases 0.000 title 1
- 101100311214 Xenopus laevis stat3.1 gene Proteins 0.000 title 1
- 201000011510 cancer Diseases 0.000 title 1
- 230000037361 pathway Effects 0.000 title 1
- 210000000130 stem cell Anatomy 0.000 title 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
- A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/92—Naphthofurans; Hydrogenated naphthofurans
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- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/24—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
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- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
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- A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
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- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/74—Naphthothiophenes
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Dermatology (AREA)
- Oncology (AREA)
- Pulmonology (AREA)
- Hematology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Rheumatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Urology & Nephrology (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Communicable Diseases (AREA)
- Vascular Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Diabetes (AREA)
- Inorganic Chemistry (AREA)
- Transplantation (AREA)
- Biophysics (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US97114407P | 2007-09-10 | 2007-09-10 | |
US1337207P | 2007-12-13 | 2007-12-13 |
Publications (1)
Publication Number | Publication Date |
---|---|
PL2194987T3 true PL2194987T3 (pl) | 2017-01-31 |
Family
ID=40452461
Family Applications (4)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PL08830471T PL2194987T3 (pl) | 2007-09-10 | 2008-09-10 | Nowe inhibitory szlaku białka stat3 oraz inhibitorów nowotworowych komórek macierzystych |
PL08830633T PL2200431T3 (pl) | 2007-09-10 | 2008-09-10 | Nowe kompozycje i metody służące leczeniu raka |
PL16156278T PL3067054T3 (pl) | 2007-09-10 | 2008-09-10 | Nowe kompozycje i sposoby leczenia nowotworów |
PL08830619.6T PL2190429T3 (pl) | 2007-09-10 | 2008-09-10 | Nowa grupa inhibitorów szlaku białka stat3 oraz inhibitorów szlaku nowotworowych komórek macierzystych |
Family Applications After (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PL08830633T PL2200431T3 (pl) | 2007-09-10 | 2008-09-10 | Nowe kompozycje i metody służące leczeniu raka |
PL16156278T PL3067054T3 (pl) | 2007-09-10 | 2008-09-10 | Nowe kompozycje i sposoby leczenia nowotworów |
PL08830619.6T PL2190429T3 (pl) | 2007-09-10 | 2008-09-10 | Nowa grupa inhibitorów szlaku białka stat3 oraz inhibitorów szlaku nowotworowych komórek macierzystych |
Country Status (14)
Country | Link |
---|---|
US (12) | US9732055B2 (pl) |
EP (6) | EP3050566B1 (pl) |
JP (16) | JP5688840B2 (pl) |
CN (6) | CN101854802B (pl) |
CA (4) | CA2736563C (pl) |
CY (3) | CY1117604T1 (pl) |
DK (4) | DK2190429T3 (pl) |
ES (3) | ES2583010T3 (pl) |
HR (3) | HRP20160430T1 (pl) |
HU (3) | HUE029111T2 (pl) |
PL (4) | PL2194987T3 (pl) |
PT (2) | PT2200431T (pl) |
SI (3) | SI2190429T1 (pl) |
WO (3) | WO2009036059A2 (pl) |
Families Citing this family (130)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
RU2405566C2 (ru) | 2005-02-03 | 2010-12-10 | Дзе Дженерал Хоспитал Корпорейшн | Способ лечения рака, устойчивого к гефитинибу |
CA2626326C (en) | 2005-11-04 | 2021-02-16 | Wyeth | Antineoplastic combinations with mtor inhibitor, herceptin, and/or hki-272 |
JP5688840B2 (ja) * | 2007-09-10 | 2015-03-25 | ボストン バイオメディカル, インコーポレイテッド | 新規のStat3経路阻害剤及び癌幹細胞阻害剤 |
US8022216B2 (en) | 2007-10-17 | 2011-09-20 | Wyeth Llc | Maleate salts of (E)-N-{4-[3-chloro-4-(2-pyridinylmethoxy)anilino]-3-cyano-7-ethoxy-6-quinolinyl}-4-(dimethylamino)-2-butenamide and crystalline forms thereof |
US20130331294A1 (en) | 2007-11-09 | 2013-12-12 | Fox Chase Cancer Center | Egfr/nedd9/tgf-beta interactome and methods of use thereof for the identification of agents having efficacy in the treatment of hyperproliferative disorders |
WO2009062199A1 (en) * | 2007-11-09 | 2009-05-14 | Fox Chase Cancer Center | EGFR/NEDD9/TGF-β LNTERACTOME AND METHODS OF USE THEREOF FOR THE IDENTIFICATION OF AGENTS HAVING EFFICACY IN THE TREATMENT OF HYPERPROLIFERATIVE DISORDERS |
UY31800A (es) * | 2008-05-05 | 2009-11-10 | Smithkline Beckman Corp | Metodo de tratamiento de cancer usando un inhibidor de cmet y axl y un inhibidor de erbb |
EP2656844B1 (en) | 2008-06-17 | 2014-12-03 | Wyeth LLC | Antineoplastic combinations containing HKI-272 and vinorelbine |
JP5675606B2 (ja) | 2008-07-08 | 2015-02-25 | ボード・オブ・リージエンツ,ザ・ユニバーシテイ・オブ・テキサス・システム | シグナル伝達性転写因子(stat)の増殖及び活性化の新規の抑制剤 |
EP2326329B1 (en) | 2008-08-04 | 2017-01-11 | Wyeth LLC | Antineoplastic combinations of 4-anilino-3-cyanoquinolines and capecitabine |
US8685941B2 (en) | 2008-12-01 | 2014-04-01 | University Of Central Florida Research Foundation, Inc. | Drug composition cytotoxic for pancreatic cancer cells |
FI3000467T3 (fi) | 2009-04-06 | 2023-03-28 | Wyeth Llc | Rintasyöpähoitokuuri, jossa käytetään neratinibia |
CN101897979B (zh) * | 2009-05-27 | 2012-08-22 | 上海市计划生育科学研究所 | 治疗前列腺疾病的靶向药物 |
US20130129675A1 (en) * | 2009-12-04 | 2013-05-23 | Board Of Regents, The University Of Texas System | Interferon therapies in combination with blockade of stat3 activation |
WO2011081205A1 (ja) * | 2009-12-28 | 2011-07-07 | 一般社団法人ファルマIp | 1,3,4-オキサジアゾール-2-カルボキサミド化合物 |
US20110275577A1 (en) * | 2010-01-08 | 2011-11-10 | Moleculin, Llc | Methods of treating dermatologic, gynecologic, and genital disorders with caffeic acid analogs |
AU2011223883B2 (en) | 2010-03-01 | 2015-10-08 | Cavion, Inc. | Cancer diagnosis and imaging |
WO2011116398A1 (en) * | 2010-03-19 | 2011-09-22 | Boston Biomedical, Inc. | Novel compounds and compositions for targeting cancer stem cells |
AU2015218436B9 (en) * | 2010-03-19 | 2017-03-09 | Boston Biomedical, Inc. | Novel Methods For Targeting Cancer Stem Cells |
CA2793527A1 (en) | 2010-03-19 | 2011-09-22 | Boston Biomedical, Inc. | Use of naphthofuran derivatives in the treatment of cancer |
CA2993363A1 (en) * | 2010-03-19 | 2011-09-22 | Boston Biomedical, Inc. | Naphthofuran compounds and compositions for targeting cancer stem cells |
WO2011130677A1 (en) * | 2010-04-16 | 2011-10-20 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Inhibitors of cancer stem cells |
US20110301194A1 (en) * | 2010-06-02 | 2011-12-08 | Arqule, Inc. | Method for Determining Treatment Efficacy |
CN103153975B (zh) * | 2010-08-24 | 2016-01-20 | 杭州益尔生物科技有限公司 | 用于疾病治疗的新型萘醌 |
WO2012036214A1 (ja) * | 2010-09-16 | 2012-03-22 | 国立大学法人大阪大学 | 自己免疫疾患、炎症性疾患、アレルギー性疾患、臓器移植に伴う症状の治療薬および予防薬 |
US20130252956A1 (en) * | 2010-11-22 | 2013-09-26 | Howard Kallender | Methods of treating cancer |
US20130230581A1 (en) * | 2010-11-30 | 2013-09-05 | Qingping Feng | Egfr antagonist for the treatment of heart disease |
WO2012078982A2 (en) * | 2010-12-09 | 2012-06-14 | The Ohio State University | Xzh-5 inhibits constitutive and interleukin-6-induced stat3 phosphorylation in human hepatocellular carcinoma cells |
CN103402993A (zh) * | 2011-03-04 | 2013-11-20 | 舟山海中洲新生药业有限公司 | 用于疾病治疗的4,9-二羟基-萘并[2,3-b] 呋喃新型酯 |
KR20120130658A (ko) * | 2011-05-23 | 2012-12-03 | 주식회사 파멥신 | 펩타이드가 융합된 이중표적항체 및 그 용도 |
MX2013014310A (es) * | 2011-06-06 | 2014-01-23 | Akebia Therapeutics Inc | Compuestos y composiciones para estabilizar el factor-2 alfa inducible por hipoxia como un metodo para tratar el cancer. |
CN103957923B (zh) * | 2011-09-12 | 2018-05-25 | 卡维昂公司 | 用于抑制包括癌干细胞在内的干细胞的增殖、发育或分化的hs.459642单基因簇产物的拮抗剂 |
CA2855368A1 (en) * | 2011-11-11 | 2013-05-16 | Millennium Pharmaceuticals, Inc. | Biomarkers of response to proteasome inhibitors |
CN104080449A (zh) * | 2012-02-17 | 2014-10-01 | 舟山海中洲新生药业有限公司 | 4,9-二羟基-萘并[2,3-b]呋喃脂肪酸酯衍生物的纳米颗粒水悬液的制备方法 |
US8940742B2 (en) | 2012-04-10 | 2015-01-27 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds and uses thereof |
WO2013166618A1 (en) * | 2012-05-08 | 2013-11-14 | Zhoushan Haizhongzhou Xinsheng Pharmaceuticals Co., Ltd. | PRODRUGS OF 4,9-DIHYDROXY-NAPHTHO[2,3-b]FURANS FOR CIRCUMVENTING CANCER MULTIDRUG RESISTANCE |
KR102427777B1 (ko) | 2012-06-26 | 2022-08-01 | 델 마 파마슈티컬스 | 디안하이드로갈락티톨, 디아세틸디안하이드로갈락티톨, 디브로모둘시톨, 또는 그의 유사체 또는 유도체를 이용하여 유전학적 다형성이 있는 환자에 있어서 티로신-키나아제-억제제 내성 악성종양, ahi1 조절곤란 또는 돌연변이를 치료하는 방법 |
CN106421795A (zh) * | 2012-10-08 | 2017-02-22 | 贾力 | 预防原发性肿瘤在手术切除后再转移的药用组合物 |
DE102013003107A1 (de) | 2013-02-25 | 2014-09-11 | Thomas Rühl | Naphthofurandione mit einer 1-Bromalkylgruppe oder einer 1-Hydroxyalkylgruppe in 2-Position und einer Alkylgruppe in 3-Position zum Furanring-Sauerstoff und Verfahren zu deren Herstellung |
EP2983674A4 (en) | 2013-04-08 | 2017-05-10 | Dennis M. Brown | Therapeutic benefit of suboptimally administered chemical compounds |
MX2015014181A (es) * | 2013-04-09 | 2016-05-24 | Boston Biomedical Inc | 2-acetilnafto [2,3-b]furano -4,9-diona para uso en el tratamiento del cáncer. |
KR102190322B1 (ko) * | 2013-04-29 | 2020-12-11 | 오제데2 파르마 | 암줄기세포 암에 대한 새로운 치료적 진단적 전략으로서 o-아세틸화된-gd2 갱글리오사이드 타겟화 |
US10745489B2 (en) | 2013-04-29 | 2020-08-18 | Ogd2 Pharma | Targeting o-acetylated gd2 ganglioside as a new therapeutic and diagnostic strategy for Cancer Stem Cells cancer |
UA121104C2 (uk) | 2013-10-04 | 2020-04-10 | Інфініті Фармасьютикалз, Інк. | Гетероциклічні сполуки і їх застосування |
US9751888B2 (en) | 2013-10-04 | 2017-09-05 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds and uses thereof |
US9795595B2 (en) * | 2014-01-27 | 2017-10-24 | Boston Biomedical, Inc. | Methods for treating cancer |
JP6695275B2 (ja) * | 2014-02-07 | 2020-05-20 | ボストン バイオメディカル, インコーポレイテッド | 3−置換カルボニル−ナフト[2,3−b]フラン誘導体又はその薬学的に許容される塩 |
WO2015120436A2 (en) | 2014-02-10 | 2015-08-13 | H. Lee Moffitt Cancer Center And Research Institute, Inc. | Stat3 phosphorylation during graft-versus-host disease |
CA2943075C (en) | 2014-03-19 | 2023-02-28 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds for use in the treatment of pi3k-gamma mediated disorders |
JP6894236B2 (ja) * | 2014-03-26 | 2021-06-30 | デノボ バイオファーマ エルエルシー | 免疫刺激活性を有するレトロウイルスベクター |
WO2015164870A1 (en) | 2014-04-25 | 2015-10-29 | H. Lee Moffitt Cancer Center And Research Institute, Inc. | Gamma-aa-peptide stat3/dna inhibitors and methods of use |
WO2015171985A1 (en) * | 2014-05-09 | 2015-11-12 | The Brigham And Women's Hospital, Inc. | Treatment of igg-immune complex-mediated organ damage |
WO2015190489A1 (ja) | 2014-06-09 | 2015-12-17 | 京都薬品工業株式会社 | 新規抗癌剤 |
AU2015289922A1 (en) * | 2014-07-15 | 2017-02-16 | The Johns Hopkins University | Suppression of myeloid derived suppressor cells and immune checkpoint blockade |
WO2016054491A1 (en) | 2014-10-03 | 2016-04-07 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds and uses thereof |
KR20160066490A (ko) * | 2014-12-02 | 2016-06-10 | 주식회사 씨앤드씨신약연구소 | 헤테로사이클 유도체 및 그의 용도 |
CA2973484A1 (en) | 2015-01-08 | 2016-07-14 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Furoquinolinediones as inhibitors of tdp2 |
JP6630364B2 (ja) | 2015-03-27 | 2020-01-15 | ボストン バイオメディカル, インコーポレイテッド | 水溶性プロドラッグ |
CN104725480A (zh) * | 2015-04-06 | 2015-06-24 | 苏州普罗达生物科技有限公司 | 一种信号传导及转录激活因子抑制多肽及其应用 |
CN104693280A (zh) * | 2015-04-06 | 2015-06-10 | 苏州普罗达生物科技有限公司 | 信号传导及转录激活因子抑制多肽及其应用 |
CN104693279A (zh) * | 2015-04-06 | 2015-06-10 | 苏州普罗达生物科技有限公司 | 关于信号传导及转录激活因子抑制多肽及其应用 |
KR20180006919A (ko) * | 2015-04-17 | 2018-01-19 | 보스톤 바이오메디칼, 인크. | 암의 치료 방법 |
MX2017013360A (es) * | 2015-04-17 | 2018-08-01 | Boston Biomedical Inc | Métodos para tratar el cáncer. |
AU2016249158A1 (en) * | 2015-04-17 | 2017-11-02 | Boston Biomedical, Inc. | Methods for treating cancer |
JP2018514557A (ja) * | 2015-04-27 | 2018-06-07 | ボストン バイオメディカル, インコーポレイテッド | Stat3経路阻害薬およびキナーゼ阻害薬を用いて癌を治療するための方法 |
EA201792509A1 (ru) * | 2015-05-14 | 2018-05-31 | НУКАНА ПиЭлСи | Лечение рака |
CN108012529A (zh) * | 2015-05-15 | 2018-05-08 | 诺华股份有限公司 | 治疗egfr突变的癌症的方法 |
AU2016271475A1 (en) * | 2015-06-03 | 2017-12-21 | Boston Biomedical, Inc. | Compositions comprising a cancer stemness inhibitor and an immunotherapeutic agent for use in treating cancer |
JP6810036B2 (ja) | 2015-07-17 | 2021-01-06 | 大日本住友製薬株式会社 | 2−アセチル−4H,9H−ナフト[2,3−b]フラン−4,9−ジオンの製造方法 |
WO2017013270A1 (en) | 2015-07-23 | 2017-01-26 | Universite De Strasbourg | Use of leptin signaling inhibitor for protecting kidneys from patients having ciliopathy |
WO2017023866A1 (en) * | 2015-07-31 | 2017-02-09 | Boston Biomedical, Inc. | Method of targeting stat3 and other non-druggable proteins |
EP3350183B1 (en) | 2015-09-14 | 2025-04-02 | Twelve Therapeutics, Inc. | Solid forms of isoquinolinone derivatives, process of making, compositions comprising, and methods of using the same |
CN108135920A (zh) | 2015-10-05 | 2018-06-08 | 努卡那有限公司 | 组合疗法 |
US20190017054A1 (en) * | 2016-01-07 | 2019-01-17 | Luni Emdad | Method of modulating survival and stemness of cancer stem cells by mda-9/syntenin (sdcbp) |
CA3011800A1 (en) | 2016-01-20 | 2017-08-03 | Boston Biomedical, Inc. | Methods for treating cancer |
CN109104862A (zh) * | 2016-03-01 | 2018-12-28 | 中央研究院 | 4,9-二氧代-4,9-二氢萘并[2,3-b]呋喃-3-羧酰胺衍生物及其用于治疗增生性疾病与感染性疾病的用途 |
US11946927B2 (en) | 2016-03-14 | 2024-04-02 | Musidora Biotechnology Llc | Process and system for identifying individuals having a high risk of inflammatory bowel disease and a method of treatment |
US10295527B2 (en) | 2016-03-14 | 2019-05-21 | Bruce Yacyshyn | Process and system for predicting responders and non-responders to mesalamine treatment of ulcerative colitis |
US10759806B2 (en) | 2016-03-17 | 2020-09-01 | Infinity Pharmaceuticals, Inc. | Isotopologues of isoquinolinone and quinazolinone compounds and uses thereof as PI3K kinase inhibitors |
WO2017164379A1 (ja) | 2016-03-25 | 2017-09-28 | 大日本住友製薬株式会社 | 2-アルキルカルボニルナフト[2,3-b]フラン-4,9-ジオンの関連物質の製造方法、及びその関連物質 |
JP2017171640A (ja) * | 2016-03-25 | 2017-09-28 | 学校法人兵庫医科大学 | 癌の治療システム |
CN105837541A (zh) * | 2016-04-23 | 2016-08-10 | 何淑琼 | 磷酸苯丙哌林的药物组合物及其在生物医药中的应用 |
CN105906595A (zh) * | 2016-04-23 | 2016-08-31 | 陈斌 | 丙酸倍氯米松的药物组合物及其在生物医药中的应用 |
GB201609600D0 (en) | 2016-06-01 | 2016-07-13 | Nucuna Biomed Ltd | Cancer treatments |
US10919914B2 (en) | 2016-06-08 | 2021-02-16 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds and uses thereof |
JP2019519573A (ja) | 2016-06-28 | 2019-07-11 | ボストン バイオメディカル, インコーポレイテッド | がんを処置するための方法 |
CN106380456B (zh) * | 2016-08-29 | 2019-03-26 | 中南大学 | 一种合成苯并呋喃萘醌衍生物的方法 |
WO2018098352A2 (en) | 2016-11-22 | 2018-05-31 | Jun Oishi | Targeting kras induced immune checkpoint expression |
US20190375723A1 (en) | 2016-11-22 | 2019-12-12 | Boston Biomedical, Inc. | New Naphtho[2,3-B]Furan Derivatives |
US11299469B2 (en) | 2016-11-29 | 2022-04-12 | Sumitomo Dainippon Pharma Oncology, Inc. | Naphthofuran derivatives, preparation, and methods of use thereof |
WO2018102506A1 (en) * | 2016-11-30 | 2018-06-07 | Tyme, Inc. | Tyrosine derivatives and compositions comprising them |
US20190358212A1 (en) * | 2017-01-22 | 2019-11-28 | Jiangsu Hengrui Medicine Co., Ltd. | Uses of egfr/her2 inhibitor combined with pyrimidine-type anti-metabolic drug |
US11963966B2 (en) | 2017-03-31 | 2024-04-23 | Dana-Farber Cancer Institute, Inc. | Compositions and methods for treating ovarian tumors |
US10646464B2 (en) | 2017-05-17 | 2020-05-12 | Boston Biomedical, Inc. | Methods for treating cancer |
WO2018225062A1 (en) * | 2017-06-04 | 2018-12-13 | Rappaport Family Institute For Research In The Medical Sciences | Method of predicting personalized response to cancer therapy and kit therefor |
EP3654841B1 (en) * | 2017-07-20 | 2024-02-07 | Board Of Supervisors Of Louisiana State University | Targeted osmotic lysis of malignant cancer cells using pulsed magnetic field gradients |
CA3074981A1 (en) | 2017-09-22 | 2019-03-28 | Sumitomo Dainippon Pharma Co., Ltd. | Chemically activated water-soluble prodrug |
CN111479584A (zh) * | 2017-11-16 | 2020-07-31 | 特尔诺沃有限公司 | 用于治疗癌症的irs/stat3双重调节剂和抗pd-1/pd-l1抗体的组合 |
EP3501511A1 (en) * | 2017-12-22 | 2019-06-26 | Fundación Centro Nacional De Investigaciones Oncológicas Carlos III | Means for preventing and treating brain metastasis |
WO2019131940A1 (ja) * | 2017-12-28 | 2019-07-04 | 株式会社カネカ | 多能性幹細胞凝集抑制剤 |
CN107973788B (zh) * | 2018-01-09 | 2021-07-09 | 沈阳药科大学 | Bbi608衍生物及其制备与用途 |
AU2019239481B2 (en) * | 2018-03-20 | 2022-11-24 | Sumitomo Pharma Co., Ltd. | Dihydrochromene derivative |
BR112020021329A2 (pt) * | 2018-04-19 | 2021-04-27 | Tvardi Therapeutics, Inc. | inibidores de stat3 |
WO2019232214A1 (en) | 2018-05-31 | 2019-12-05 | Boston Biomedical, Inc. | Methods of using napabucasin |
AU2019341976A1 (en) * | 2018-09-18 | 2021-04-15 | General Incorporated Association Pharma Valley Project Supporting Organization | Cancer combination therapy using quinoline carboxamide derivative |
MX2021004151A (es) * | 2018-10-12 | 2021-09-08 | 1Globe Biomedical Co Ltd | Nueva solución de combinación para el tratamiento contra cáncer refractario a la quimioterapia. |
CN109223758A (zh) * | 2018-10-31 | 2019-01-18 | 南京先进生物材料与过程装备研究院有限公司 | 一种紫杉醇和芴类stat3抑制剂联合用药物组合物 |
CN109846888A (zh) * | 2018-10-31 | 2019-06-07 | 南京先进生物材料与过程装备研究院有限公司 | 一种紫杉醇和吲哚类stat3抑制剂联合用药物组合物 |
CN109331004A (zh) * | 2018-10-31 | 2019-02-15 | 南京先进生物材料与过程装备研究院有限公司 | 一种紫杉醇和二苯并[b,d]噻吩类STAT抑制剂甲磺酸盐A晶型联合用药物组合物 |
CN109966297A (zh) * | 2018-10-31 | 2019-07-05 | 南京先进生物材料与过程装备研究院有限公司 | 一种紫杉醇和咔唑类stat抑制剂马来酸盐晶型i联合用药物组合物 |
CN109288846A (zh) * | 2018-10-31 | 2019-02-01 | 南京先进生物材料与过程装备研究院有限公司 | 一种紫杉醇和咔唑类stat3抑制剂晶型a联合用药物组合物 |
CN109172563A (zh) * | 2018-10-31 | 2019-01-11 | 南京先进生物材料与过程装备研究院有限公司 | 一种噻吨酮类紫杉醇和stat3抑制剂联合用药物组合物 |
CN109200044A (zh) * | 2018-10-31 | 2019-01-15 | 南京先进生物材料与过程装备研究院有限公司 | 一种紫杉醇和二苯并[b,d]噻吩类STAT抑制剂酒石酸盐联合用药物组合物 |
CN109288845A (zh) * | 2018-10-31 | 2019-02-01 | 南京先进生物材料与过程装备研究院有限公司 | 一种咔唑类stat抑制剂马来酸盐晶型ii联合用药物组合物及其制备方法 |
CN109288847A (zh) * | 2018-10-31 | 2019-02-01 | 南京先进生物材料与过程装备研究院有限公司 | 一种紫杉醇和咔唑类stat抑制剂甲磺酸盐晶型p联合用药物组合物 |
CN109200052A (zh) * | 2018-10-31 | 2019-01-15 | 南京先进生物材料与过程装备研究院有限公司 | 一种紫杉醇和芴酮类stat3抑制剂联合用药物组合物 |
CN109364252B (zh) * | 2018-11-21 | 2021-09-28 | 南京大学 | 抑制ifn-i至arg1诱导通路在制备抗肿瘤药物组合物中的应用 |
WO2020207344A1 (zh) * | 2019-04-09 | 2020-10-15 | 健艾仕生物医药有限公司 | 匹莫齐特和甲氨蝶呤的药物组合及其应用 |
US11564913B2 (en) * | 2019-05-03 | 2023-01-31 | Children's Hospital Medical Center | Compositions and methods for treating cancer |
CN110218198B (zh) * | 2019-05-22 | 2022-06-28 | 广州中医药大学(广州中医药研究院) | 一种萘醌并三氮唑核心骨架衍生物化合物及其制备方法和应用 |
WO2020251015A1 (ja) * | 2019-06-14 | 2020-12-17 | 大日本住友製薬株式会社 | 2-アルキルカルボニル[2,3-b]フラン-4,9-ジオンの製造方法、及びその製造中間体 |
JP7287929B2 (ja) * | 2019-09-25 | 2023-06-06 | 住友ファーマ株式会社 | ジヒドロクロメン誘導体を含有する医薬 |
CN114761006A (zh) * | 2019-11-08 | 2022-07-15 | Inserm(法国国家健康医学研究院) | 对激酶抑制剂产生耐药性的癌症的治疗方法 |
TW202131923A (zh) * | 2019-11-20 | 2021-09-01 | 耶魯大學 | 用於治療局部缺血-再灌注損傷及/或肺損傷的化合物、組成物及方法 |
KR20220124170A (ko) * | 2019-12-05 | 2022-09-13 | 더 보드 오브 리젠츠 오브 더 유니버시티 오브 텍사스 시스템 | 간 섬유증 및 섬유증 관련 기타 질환에 대한 엑소좀 기반 치료요법 |
CN115135326B (zh) * | 2020-03-16 | 2024-09-13 | 正大天晴药业集团股份有限公司 | 作为c-Met激酶抑制剂的化合物的联用药物组合物及其用途 |
JP2023525767A (ja) * | 2020-05-11 | 2023-06-19 | パーデュー・リサーチ・ファウンデーション | 連続フロー条件下でのロムスチンのスケールアップ合成 |
CN114286684B (zh) * | 2020-07-27 | 2024-01-05 | 华中科技大学 | 与stat3相关的疾病的预防和/或治疗 |
WO2022216930A1 (en) * | 2021-04-08 | 2022-10-13 | Virginia Commonwealth University | Novel mda-9 antagonist with anti-metastatic potential |
CN114591306B (zh) * | 2022-03-03 | 2024-03-01 | 陕西中医药大学 | 一种1,2,4-三唑环的1,4萘醌类stat3抑制剂及其应用 |
Family Cites Families (84)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2472133A (en) * | 1947-03-20 | 1949-06-07 | Du Pont | Thiophanthraquinone derivatives |
SU1049490A1 (ru) | 1982-05-18 | 1983-10-23 | Ордена Трудового Красного Знамени Институт Химии Ан Мсср | (3 @ ,9 @ ,9 @ )-6,6,9 @ -Триметилтранспергидронафто(2,1- @ )фуран,в качестве душистого компонента парфюмерной композиции |
JPS616149A (ja) | 1984-06-20 | 1986-01-11 | Mitsubishi Electric Corp | 無機絶縁体の製法 |
JPS63196576A (ja) * | 1987-02-10 | 1988-08-15 | Tetsuo Ikegawa | フラルナフトキノン誘導体と制癌剤及びその製造方法 |
EP0309926A3 (de) | 1987-09-29 | 1990-12-05 | Siemens Aktiengesellschaft | Verfahren zur Herstellung vollparametrisierbarer Schaltungen in integrierter Schaltkreistechnik |
JPH01121284A (ja) | 1987-11-06 | 1989-05-12 | Eisai Co Ltd | トコフェロール n,n−ジアルキルアミノアルキルカルボン酸エステルの胆汁酸塩 |
EP0402192A1 (fr) | 1989-05-31 | 1990-12-12 | BODET, Jean Augustin | Article en carton ou matière analogue et procédé de fabrication |
JPH04139177A (ja) * | 1989-12-28 | 1992-05-13 | Dainippon Ink & Chem Inc | フラルベンゾキノン誘導体及びその製造方法並びに制癌剤 |
DE69131873T2 (de) * | 1990-07-10 | 2000-06-15 | Canon K.K., Tokio/Tokyo | Elektrophotographisches, lichtempfindliches Element |
JP2942015B2 (ja) * | 1990-07-10 | 1999-08-30 | キヤノン株式会社 | 電子写真感光体およびそれを用いた電子写真装置 |
TW252136B (pl) * | 1992-10-08 | 1995-07-21 | Ciba Geigy | |
JP3598168B2 (ja) | 1996-03-18 | 2004-12-08 | 独立行政法人 科学技術振興機構 | 抗ウイルス剤 |
JPH1121284A (ja) | 1997-06-30 | 1999-01-26 | Kotobuki:Kk | フラノナフトキノン誘導体及びこれを含有する医薬 |
JPH1165141A (ja) * | 1997-08-11 | 1999-03-05 | Canon Inc | 電子写真感光体、該電子写真感光体を有するプロセスカ−トリッジ及び電子写真装置 |
US6174913B1 (en) * | 1998-06-05 | 2001-01-16 | The University Of North Carolina At Chapel Hill | Naphtho- and dihydrobenzo-thiophene derivatives as cytotoxic antitumor agents |
AU2736400A (en) * | 1999-01-27 | 2000-08-18 | University Of South Florida | Inhibition of stat3 signal transduction for human cancer therapy |
DE60042968D1 (de) | 1999-04-01 | 2009-10-29 | Hana Biosciences Inc | Zusammensetzungen und methoden zur behandlung lymphoma |
US6482943B1 (en) * | 1999-04-30 | 2002-11-19 | Slil Biomedical Corporation | Quinones as disease therapies |
JP3961827B2 (ja) * | 1999-08-02 | 2007-08-22 | エフ.ホフマン−ラ ロシュ アーゲー | 新規な選択的レチノイドアゴニスト |
JP2001097860A (ja) | 1999-09-29 | 2001-04-10 | Japan Science & Technology Corp | 抗薬剤耐性菌剤と抗クラミジア剤 |
UA75055C2 (uk) | 1999-11-30 | 2006-03-15 | Пфайзер Продактс Інк. | Похідні бензоімідазолу, що використовуються як антипроліферативний засіб, фармацевтична композиція на їх основі |
KR20010100194A (ko) * | 2000-03-13 | 2001-11-14 | 박호군 | 여러 가지 물질의 가용화용 조성물과 제형 및 그들의제조방법 |
WO2002078617A2 (en) | 2001-03-28 | 2002-10-10 | University Of South Florida | Materials and methods for treatment of cancer and identification of anti-cancer compounds |
GB0117696D0 (en) | 2001-07-20 | 2001-09-12 | Bradford Particle Design Plc | Particle information |
US20040092428A1 (en) | 2001-11-27 | 2004-05-13 | Hongming Chen | Oral pharmaceuticals formulation comprising paclitaxel, derivatives and methods of administration thereof |
WO2003045979A2 (en) | 2001-11-29 | 2003-06-05 | Therakos, Inc. | Methods for pretreating a subject with extracorporeal photopheresis and/or apoptotic cells |
JP2005533748A (ja) * | 2002-03-08 | 2005-11-10 | シグナル ファーマシューティカルズ,インコーポレイテッド | 増殖性障害および癌を治療、予防、または管理するための併用療法 |
DE60307701T2 (de) * | 2002-03-15 | 2007-10-11 | Natimmune A/S | Mannose-Bindungsprotein enthaltende pharmazeutische Zusammensetzungen |
WO2004024145A1 (en) | 2002-09-10 | 2004-03-25 | Dabur Research Foundation | Anti-cancer activity of carvedilol and its isomers |
EP1551392A4 (en) | 2002-09-17 | 2006-09-20 | Arqule Inc | NEW LAPACHO COMPOUNDS AND APPLICATION METHOD THEREFOR |
TWI323662B (en) | 2002-11-15 | 2010-04-21 | Telik Inc | Combination cancer therapy with a gst-activated anticancer compound and another anticancer therapy |
TWI335913B (en) | 2002-11-15 | 2011-01-11 | Vertex Pharma | Diaminotriazoles useful as inhibitors of protein kinases |
IS6633A (is) * | 2002-11-22 | 2004-05-23 | Omega Farma Ehf. | Samsetningar af fínasteríð töflum |
KR20060031809A (ko) * | 2003-06-09 | 2006-04-13 | 더 리젠츠 오브 더 유니버시티 오브 미시간 | 암 치료 및 진단용 조성물 및 방법 |
JP2007502777A (ja) | 2003-08-13 | 2007-02-15 | ユニバーシティー オブ サウス フロリダ | 腫瘍の処置のための白金錯体 |
US20050049207A1 (en) * | 2003-09-03 | 2005-03-03 | Kaufmann Doug A. | Method of treating and preventing cancer |
WO2005033048A2 (en) * | 2003-09-29 | 2005-04-14 | The Johns Hopkins University | Wnt pathway antagonists |
PL1706133T3 (pl) | 2003-12-02 | 2011-04-29 | Cleveland Clinic Found | Sposoby ochrony przed promieniowaniem z użyciem flageliny |
AU2004298511B2 (en) * | 2003-12-11 | 2011-08-11 | Board Of Regents, The University Of Texas System | Compounds for treatment of cell proliferative diseases |
DE10359828A1 (de) * | 2003-12-12 | 2005-07-28 | Zoser B. Dr.Rer.Nat. Salama | CHP-Gemcitabin- Kombinationsmittel und ihre Verwendung als Antitumorwirkstoffe, insbesondere Antimetastasierungswirkstoffe |
WO2005110477A2 (en) * | 2004-04-09 | 2005-11-24 | University Of South Florida | Combination therapies for cancer and proliferative angiopathies |
JP2004224802A (ja) * | 2004-04-21 | 2004-08-12 | Japan Science & Technology Agency | 抗菌剤 |
MX2007000265A (es) * | 2004-07-02 | 2007-07-20 | Icos Corp | Compuestos utiles para inhibir chk1. |
EP1781673B1 (en) * | 2004-08-18 | 2009-10-21 | AstraZeneca AB | Selected fused heterocyclics and uses thereof |
CA2587276A1 (en) * | 2004-11-08 | 2006-05-18 | Baxter International Inc. | Nanoparticulate compositions of tubulin inhibitor compounds |
BRPI0517887A (pt) * | 2004-11-24 | 2008-10-21 | Novartis Ag | combinações de inibidores de jaks |
US7807662B2 (en) * | 2004-12-23 | 2010-10-05 | University Of South Florida | Platinum IV complex inhibitor |
JP2008535785A (ja) * | 2005-02-25 | 2008-09-04 | ザ リージェンツ オブ ザ ユニバーシティ オブ ミシガン | Stat3の小分子阻害剤およびその使用 |
JP2006248978A (ja) * | 2005-03-10 | 2006-09-21 | Mebiopharm Co Ltd | 新規なリポソーム製剤 |
JP2006290871A (ja) | 2005-03-16 | 2006-10-26 | Taheebo Japan Kk | 抗癌性を示す化合物およびその中間体ならびにそれらの製造方法 |
US20060252073A1 (en) * | 2005-04-18 | 2006-11-09 | Regents Of The University Of Michigan | Compositions and methods for the treatment of cancer |
JPWO2006126505A1 (ja) | 2005-05-26 | 2008-12-25 | 国立大学法人 東京大学 | Stat機能阻害剤およびその応用 |
WO2007013946A2 (en) * | 2005-07-20 | 2007-02-01 | University Of South Florida | Method of predicting responsiveness to chemotherapy and selecting treatments |
WO2007042912A2 (en) | 2005-10-13 | 2007-04-19 | Orchid Research Laboratories Limited | Heterocyclic compounds as pstat3/il-6 inhibitors |
UA96139C2 (uk) * | 2005-11-08 | 2011-10-10 | Дженентек, Інк. | Антитіло до нейропіліну-1 (nrp1) |
AR057579A1 (es) * | 2005-11-23 | 2007-12-05 | Merck & Co Inc | Compuestos espirociclicos como inhibidores de histona de acetilasa (hdac) |
JP2007145680A (ja) | 2005-11-30 | 2007-06-14 | Idemitsu Kosan Co Ltd | 水素発生材料および水素発生方法 |
US20090209494A1 (en) * | 2005-12-24 | 2009-08-20 | Christine Janet Martin | 21-deoxymacbecin analogues useful as antitumor agents |
CA2635209A1 (en) * | 2006-01-12 | 2007-08-02 | Merck & Co., Inc. | Fluorinated arylamide derivatives |
EP2001438A2 (en) * | 2006-02-09 | 2008-12-17 | Macusight, Inc. | Stable formulations, and methods of their preparation and use |
US20070243192A1 (en) * | 2006-02-21 | 2007-10-18 | Regents Of The University Of Michigan | Growth hormone receptor antagonist cancer treatment |
AU2007218966A1 (en) * | 2006-02-24 | 2007-08-30 | Merck Frosst Canada Ltd. | 2-(phenyl or heterocyclic) - 1h-phenanthro [9,10-d] imidazoles |
WO2007115269A2 (en) * | 2006-03-31 | 2007-10-11 | The Board Of Regents Of The University Of Texas System | Orally bioavailable caffeic acid related anticancer drugs |
US20070238770A1 (en) | 2006-04-05 | 2007-10-11 | Bristol-Myers Squibb Company | Process for preparing novel crystalline forms of peliglitazar, novel stable forms produced therein and formulations |
WO2008094321A2 (en) | 2006-10-04 | 2008-08-07 | Universtiy Of South Florida | Akt sensitization of cancer cells |
WO2008077062A2 (en) * | 2006-12-19 | 2008-06-26 | Board Of Regents, The University Of Texas System | Suppression of stat3 reactivation after src kinase inhibition to treat cancer |
JP4077863B1 (ja) | 2007-05-31 | 2008-04-23 | タヒボジャパン株式会社 | 抗癌活性を有する光学活性2−(1−ヒドロキシエチル)−5−ヒドロキシナフト[2,3−b]フラン−4,9−ジオンの製法 |
JP5688840B2 (ja) | 2007-09-10 | 2015-03-25 | ボストン バイオメディカル, インコーポレイテッド | 新規のStat3経路阻害剤及び癌幹細胞阻害剤 |
WO2009060282A2 (en) | 2007-11-06 | 2009-05-14 | Orchid Research Laboratories Limited | Stilbene derivatives as pstat3/il-6 inhibitors |
WO2011116398A1 (en) | 2010-03-19 | 2011-09-22 | Boston Biomedical, Inc. | Novel compounds and compositions for targeting cancer stem cells |
CA2793527A1 (en) | 2010-03-19 | 2011-09-22 | Boston Biomedical, Inc. | Use of naphthofuran derivatives in the treatment of cancer |
AU2015218436B9 (en) | 2010-03-19 | 2017-03-09 | Boston Biomedical, Inc. | Novel Methods For Targeting Cancer Stem Cells |
CA2993363A1 (en) | 2010-03-19 | 2011-09-22 | Boston Biomedical, Inc. | Naphthofuran compounds and compositions for targeting cancer stem cells |
CN103402993A (zh) | 2011-03-04 | 2013-11-20 | 舟山海中洲新生药业有限公司 | 用于疾病治疗的4,9-二羟基-萘并[2,3-b] 呋喃新型酯 |
US8977803B2 (en) | 2011-11-21 | 2015-03-10 | Western Digital Technologies, Inc. | Disk drive data caching using a multi-tiered memory |
WO2013166618A1 (en) | 2012-05-08 | 2013-11-14 | Zhoushan Haizhongzhou Xinsheng Pharmaceuticals Co., Ltd. | PRODRUGS OF 4,9-DIHYDROXY-NAPHTHO[2,3-b]FURANS FOR CIRCUMVENTING CANCER MULTIDRUG RESISTANCE |
MX2015014181A (es) | 2013-04-09 | 2016-05-24 | Boston Biomedical Inc | 2-acetilnafto [2,3-b]furano -4,9-diona para uso en el tratamiento del cáncer. |
KR20180006919A (ko) | 2015-04-17 | 2018-01-19 | 보스톤 바이오메디칼, 인크. | 암의 치료 방법 |
MX2017013360A (es) | 2015-04-17 | 2018-08-01 | Boston Biomedical Inc | Métodos para tratar el cáncer. |
AU2016249158A1 (en) | 2015-04-17 | 2017-11-02 | Boston Biomedical, Inc. | Methods for treating cancer |
JP2018514557A (ja) | 2015-04-27 | 2018-06-07 | ボストン バイオメディカル, インコーポレイテッド | Stat3経路阻害薬およびキナーゼ阻害薬を用いて癌を治療するための方法 |
AU2016271475A1 (en) | 2015-06-03 | 2017-12-21 | Boston Biomedical, Inc. | Compositions comprising a cancer stemness inhibitor and an immunotherapeutic agent for use in treating cancer |
CA3011800A1 (en) | 2016-01-20 | 2017-08-03 | Boston Biomedical, Inc. | Methods for treating cancer |
US10646464B2 (en) | 2017-05-17 | 2020-05-12 | Boston Biomedical, Inc. | Methods for treating cancer |
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