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KR970701180A - 3-이속사졸카복실산의 제조 방법(process for producing 3-isoxazole-carboxylic acid) - Google Patents

3-이속사졸카복실산의 제조 방법(process for producing 3-isoxazole-carboxylic acid)

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Publication number
KR970701180A
KR970701180A KR1019960704440A KR19960704440A KR970701180A KR 970701180 A KR970701180 A KR 970701180A KR 1019960704440 A KR1019960704440 A KR 1019960704440A KR 19960704440 A KR19960704440 A KR 19960704440A KR 970701180 A KR970701180 A KR 970701180A
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KR
South Korea
Prior art keywords
compound
general formula
producing
formula
carboxylic acid
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Application number
KR1019960704440A
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English (en)
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KR100330609B1 (ko
Inventor
스스무 다카다
노부오 조메이
마사아키 우에나카
Original Assignee
시오노 요시히코
시오노기 세이야쿠 가부시키가이샤
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D263/34—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
    • C07D261/04—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
    • C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
    • C07D261/10—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D261/18—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

본 발명은 하기 일반식(I)의 화합물을 하이드록실아민과 반응시켜 하기 일반식(II)의 화합물을 생성하고, 이어서 생성된 화합물을 알칼리로 처리하는 것을 특징으로 하는, 유용한 화합물을 제조하기 위한 중간체인 3-이소사졸카복실산의 제조방법에 관한 것이다.
상기 식에서, R1은 저급 알킬이고, R2은 카복시 그룹이고, X는 할로겐 원자이고, Y는 수소 원자이거나, 또는 X 및 Y는 함께 단일 결합을 형성한다.

Description

3-이속사졸카복실산의 제조 방법(PROCESS FOR PRODUCING 3-ISOXAZOLECARBOXYLIC ACID)
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (3)

  1. 하기 일반식(I)의 화합물을 하이드록실아민과 반응시키는 것을 특징으로 하는, 하기 일반식(II)의 화합물의 제조방법;
    상기 식에서, R1은 저급 알킬이고, R2은 카복시 보호 그룹이고, X는 할로겐 원자이고, Y는 수소 원자이거나, 또는 X 및 Y는 함께 단일 결합을 형성한다.
  2. 하기일반식(I)의 화합물을 하이드록실아민과 반응시켜 하기 일반식(II)의 화합물을 생성하고, 생성된 화합물을 알칼리로 처리하는 것을 특징으로 하는, 하기 일반식(III)의 3-이속졸카복실산의 제조방법;
    상기 식에서, R1은 저급 알킬이고, R2은 카복시 보호 그룹이고, X는 할로겐 원자이고, Y는 수소 원자이거나, 또는 X 및 Y는 함께 단일 결합을 형성한다.
  3. 하기 일반식(II)의 화합물을 알칼리로 처리하는 것을 특징으로 하는, 하기 일반식(III)의 3-이속사졸카복실산의 제조방법.
    상기식에서, R1은 저급 알킬이고, R2은 카복시 보호 그룹이다.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019960704440A 1994-02-16 1995-02-15 3-이속사졸카복실산의 제조방법 Expired - Fee Related KR100330609B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP94/19380 1994-02-16
JP1938094 1994-02-16
PCT/JP1995/000211 WO1995022533A1 (en) 1994-02-16 1995-02-15 Process for producing 3-isoxazolecarboxylic acid

Publications (2)

Publication Number Publication Date
KR970701180A true KR970701180A (ko) 1997-03-17
KR100330609B1 KR100330609B1 (ko) 2002-11-22

Family

ID=11997714

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019960704440A Expired - Fee Related KR100330609B1 (ko) 1994-02-16 1995-02-15 3-이속사졸카복실산의 제조방법

Country Status (10)

Country Link
US (2) US5696271A (ko)
EP (2) EP0739885B1 (ko)
JP (1) JP3647455B2 (ko)
KR (1) KR100330609B1 (ko)
AU (1) AU1717495A (ko)
CA (1) CA2183426A1 (ko)
DE (2) DE69516396T2 (ko)
ES (2) ES2183476T3 (ko)
HU (1) HU214086B (ko)
WO (1) WO1995022533A1 (ko)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2213737B1 (en) 2002-02-01 2012-11-07 Life Technologies Corporation Double-stranded oligonucleotides
US20060009409A1 (en) 2002-02-01 2006-01-12 Woolf Tod M Double-stranded oligonucleotides
US6727277B1 (en) 2002-11-12 2004-04-27 Kansas State University Research Foundation Compounds affecting cholesterol absorption
BR112020011828B1 (pt) 2017-12-15 2021-02-23 Kumiai Chemical Industry Co., Ltd Processo para produzir um composto
CN115806531B (zh) * 2021-09-14 2024-05-28 新发药业有限公司 一种4,5-二氢-5,5-二苯基异噁唑-3-甲酸及其衍生物的制备方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU658629B2 (en) * 1991-05-01 1995-04-27 Taiho Pharmaceutical Co., Ltd. Novel isoxazole derivative and salt thereof
DE4201047A1 (de) * 1992-01-17 1993-07-22 Bayer Ag Substituierte isoxazolcarbonsaeureamide
US5633272A (en) * 1995-02-13 1997-05-27 Talley; John J. Substituted isoxazoles for the treatment of inflammation
US5514505A (en) * 1995-05-15 1996-05-07 Xerox Corporation Method for obtaining improved image contrast in migration imaging members

Also Published As

Publication number Publication date
AU1717495A (en) 1995-09-04
ES2145905T3 (es) 2000-07-16
EP0957097A1 (en) 1999-11-17
EP0739885B1 (en) 2000-04-19
ES2183476T3 (es) 2003-03-16
HU9602278D0 (en) 1996-10-28
CA2183426A1 (en) 1995-08-24
US5760244A (en) 1998-06-02
DE69516396D1 (de) 2000-05-25
DE69516396T2 (de) 2000-08-31
EP0957097B1 (en) 2002-08-28
KR100330609B1 (ko) 2002-11-22
EP0739885A4 (en) 1997-04-16
HUT75051A (en) 1997-03-28
US5696271A (en) 1997-12-09
HU214086B (en) 1997-12-29
DE69527997T2 (de) 2003-05-28
EP0739885A1 (en) 1996-10-30
JP3647455B2 (ja) 2005-05-11
WO1995022533A1 (en) 1995-08-24
DE69527997D1 (de) 2002-10-02

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