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KR910000743A - 티에노피란 유도체, 이의 제조방법 및 용도 - Google Patents

티에노피란 유도체, 이의 제조방법 및 용도 Download PDF

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Publication number
KR910000743A
KR910000743A KR1019900009322A KR900009322A KR910000743A KR 910000743 A KR910000743 A KR 910000743A KR 1019900009322 A KR1019900009322 A KR 1019900009322A KR 900009322 A KR900009322 A KR 900009322A KR 910000743 A KR910000743 A KR 910000743A
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KR
South Korea
Prior art keywords
compound
formula
radical
integer
membrane
Prior art date
Application number
KR1019900009322A
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English (en)
Inventor
빈더 디터
로벤스즈키 프란쯔
빈베르거 요세프
페터 페르버 후베르트
Original Assignee
트론트 야콥센
케미쉬 파마조이티쉐 포르슝스게젤샤프트 엠. 베. 하
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 트론트 야콥센, 케미쉬 파마조이티쉐 포르슝스게젤샤프트 엠. 베. 하 filed Critical 트론트 야콥센
Publication of KR910000743A publication Critical patent/KR910000743A/ko

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

내용 없음

Description

티에노피란 유도체, 이의 제조방법 및 용도
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (17)

  1. 하기 일반식(Ⅰ)의 화합물.
  3. 상기 식에서, 라디칼은
  5. 중의 하나를 나타내고, R은 수소 또는 라디칼-CN, -CHO, -CH=NOH, -CONH2또는 -COOR1를 나타내며, R1은 라디칼(C1-C4)-알킬을 나타내고, n은 3, 4 또는 5의 정수이다.
  6. 제1항에 있어서, 트란스-6, 7-디하이드로-5, 5-디메틸-6-하이드록시-7-(2-옥소-1-피톨리디닐)-5H-티에노〔3, 2-b〕피란-2-카보니트릴인 화합물.
  7. 제1항에 있어서, 트란스-6, 7-디하이드로-5, 5-디메틸-6-하이드록시-7-(2-옥소-1-피톨리디닐)-5H-티에노〔3, 2-b〕피란-2-카보니트릴인 화합물.
  8. 제1항에 있어서, 순수한 에난티오며 형태로 존재하는 화합물.
  9. 제1항에 있어서, 광학적 대장체의 혼합물 형태로 존재하는 화합물.
  10. 2당량 이상의 비친핵성 강염기의 존재하에 불활성 유기 희석제중에서 일반식(Ⅲ)의 화합물을 일반식(Ⅳ)의 화합물과 반응시키고, 경우에 따라, 수득된 라세미체를 에난티오머로 분리시킴을 특징으로 하여, 제1항에 따른 일반식(Ⅰ)의 화합물을 제조하는 방법.
  12. 상기 식에서, 라디칼은
  14. 중의 하나를 나타내고, X는 염소, 브롬 또는 요오드를 나타내고, n은 3,4 또는 5의 정수이다.
  15. 막 K+채널을 활성화시켜 완화 또는 치료할 수 있는 질병을 치료하기에 유효한 양의 일반식(Ⅰ)의 화합물과 함께 약제학적으로 허용되는 부형제, 담체 또는 희석제를 포함하는 약제학적 조성물.
  16. 환자에게 일반식(Ⅰ)의 화합물의 유효량을 투여함을 특징으로 하여, 막 K+채널을 활성화시켜 완화 또는 치료할 수 있는 질병을 치료하는 방법.
  17. ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것
KR1019900009322A 1989-06-27 1990-06-23 티에노피란 유도체, 이의 제조방법 및 용도 KR910000743A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
AT157389 1989-06-27
AT1573/89 1989-06-27

Publications (1)

Publication Number Publication Date
KR910000743A true KR910000743A (ko) 1991-01-30

Family

ID=3516340

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019900009322A KR910000743A (ko) 1989-06-27 1990-06-23 티에노피란 유도체, 이의 제조방법 및 용도

Country Status (28)

Country Link
US (1) US5077307A (ko)
EP (1) EP0405298B1 (ko)
KR (1) KR910000743A (ko)
CN (1) CN1025621C (ko)
AT (1) ATE105559T1 (ko)
AU (1) AU628995B2 (ko)
CA (1) CA2019737A1 (ko)
CZ (1) CZ280543B6 (ko)
DD (1) DD295850A5 (ko)
DE (1) DE59005666D1 (ko)
DK (1) DK0405298T3 (ko)
ES (1) ES2053015T3 (ko)
FI (1) FI96312C (ko)
HR (1) HRP940819A2 (ko)
HU (1) HU204834B (ko)
IE (1) IE63935B1 (ko)
IL (1) IL94703A (ko)
LT (1) LT3799B (ko)
LV (1) LV10776A (ko)
MD (1) MD121C2 (ko)
NO (1) NO174423C (ko)
NZ (1) NZ234084A (ko)
PT (1) PT94487B (ko)
RU (1) RU1833386C (ko)
SK (1) SK278012B6 (ko)
UA (1) UA15930A (ko)
YU (1) YU124690A (ko)
ZA (1) ZA904885B (ko)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ230711A (en) * 1988-09-23 1990-10-26 Ortho Pharma Corp Substituted thienopyrans as antihypertensive agents
DE3925719A1 (de) * 1989-08-03 1991-02-07 Bayer Ag Substituierte thienopyranone, verfahren zu ihrer herstellung und ihre verwendung zur bekaempfung von parasiten
NZ240933A (en) * 1990-12-21 1993-05-26 Ortho Pharma Corp Preparing enantiomerically pure thienopyran derivatives
GB9909792D0 (en) * 1998-12-04 1999-06-23 Cambridge Bioclinical Limited Potassium channel activators and their use
MD149Z5 (ro) * 2009-09-17 2010-09-30 Сергей Чербарь Sigiliu cu fibre optice din polimer
MD4034C2 (ro) * 2009-11-03 2010-11-30 Сергей Чербарь Sigiliu indicator pentru dispozitive metrologice
MD4230C1 (ro) * 2012-11-29 2013-12-31 Фёдор СЫРБУ Sigiliu
MD861Z (ro) * 2014-06-03 2015-07-31 Александр КОРЕНКОВ Sigiliu
MD4534C1 (ro) * 2017-03-03 2018-06-30 Сергей Чербарь Sigiliu cu rotor blocabil pentru dispozitive metrologice

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3274350D1 (en) * 1981-09-25 1987-01-08 Beecham Group Plc Pharmaceutically active benzopyran compounds
GB8308062D0 (en) * 1983-03-24 1983-05-05 Beecham Group Plc Active compounds
DE3682331D1 (de) * 1985-06-08 1991-12-12 Beecham Group Plc Pyrano(3,2-c)pyridinderivate, verfahren und zwischenprodukte zu ihrer herstellung und diese enthaltende pharmazeutische zubereitungen.
GB8613786D0 (en) * 1986-06-06 1986-07-09 Beecham Group Plc Active compounds
EP0277611B1 (de) * 1987-02-04 1993-06-16 Hoechst Aktiengesellschaft Alkylsubstituierte N-Benzopyranyllactame, Verfahren zu ihrer Herstellung, ihre Verwendung sowie pharmazeutische Präparate auf Basis dieser Verbindungen
US4789525A (en) * 1987-06-22 1988-12-06 Eastman Kodak Company Analytical method and multilayer element for total ionic iron determination
NZ230711A (en) * 1988-09-23 1990-10-26 Ortho Pharma Corp Substituted thienopyrans as antihypertensive agents

Also Published As

Publication number Publication date
LT3799B (en) 1996-03-25
FI903172A0 (fi) 1990-06-25
IE902097L (en) 1990-12-27
IL94703A (en) 1994-07-31
EP0405298A1 (de) 1991-01-02
AU628995B2 (en) 1992-09-24
CN1048388A (zh) 1991-01-09
DD295850A5 (de) 1991-11-14
CZ317290A3 (en) 1995-10-18
DE59005666D1 (de) 1994-06-16
FI96312B (fi) 1996-02-29
IE63935B1 (en) 1995-06-28
CA2019737A1 (en) 1990-12-27
NZ234084A (en) 1992-03-26
LTIP1590A (en) 1995-06-26
IE902097A1 (en) 1991-01-02
NO902832D0 (no) 1990-06-26
SK317290A3 (en) 1995-10-11
LV10776A (lv) 1995-08-20
IL94703A0 (en) 1991-04-15
CN1025621C (zh) 1994-08-10
HRP940819A2 (en) 1996-08-31
AU5778790A (en) 1991-01-03
US5077307A (en) 1991-12-31
CZ280543B6 (cs) 1996-02-14
NO902832L (no) 1990-12-28
MD121B1 (ro) 1994-12-31
HU204834B (en) 1992-02-28
UA15930A (uk) 1997-06-30
DK0405298T3 (da) 1994-06-06
YU124690A (en) 1991-10-31
NO174423B (no) 1994-01-24
NO174423C (no) 1994-05-04
FI96312C (fi) 1996-06-10
ES2053015T3 (es) 1994-07-16
PT94487A (pt) 1991-02-08
PT94487B (pt) 1997-02-28
ZA904885B (en) 1991-03-27
EP0405298B1 (de) 1994-05-11
SK278012B6 (en) 1995-10-11
MD121C2 (ro) 1995-06-30
HUT55787A (en) 1991-06-28
ATE105559T1 (de) 1994-05-15
HU903998D0 (en) 1990-11-28
RU1833386C (ru) 1993-08-07

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