KR20150092739A

KR20150092739A - 예측변수 인자들을 이용하여 동정된 환자 부분모집단에서 암 치료를 위한 마시티닙의 용도

Info

Publication number: KR20150092739A
Application number: KR1020157011764A
Authority: KR
Inventors: 알랑 무시; 장-피에르 키넷; 다비드 피크말
Original assignee: 에이비 사이언스
Priority date: 2012-10-04
Filing date: 2013-10-04
Publication date: 2015-08-13
Anticipated expiration: 2033-10-04
Also published as: JP2015532296A; BR112015007144A2; IL238107B; AR092899A1; CN104968347A; JP6234466B2; AU2013326463A1; MX2015004264A; TW201414475A; ZA201503054B; DK2903616T3; CA2886979C; EP2903616B1; US10238649B2; EP2903616B8; SI2903616T1; WO2014053650A1; ES2656640T3; EP2903616A1; SG11201502626PA

Abstract

본 발명은 암에 걸린 환자들의 치료방법에 관한 것으로서, 본 발명에서 상기 환자들은 티로신 키나제 저해제, 비만세포 저해제 또는 c-Kit 저해제, 특히 마시티닙을 이용하여 치료되며, 임의로 적어도 1종의 항종양제를 조합 사용할 수 있다. 티로신 키나제 저해제, 비만세포 저해제 또는 c-Kit 저해제, 및 임의의 적어도 1종의 항종양제는 치료적 유효량을 포함하는 투여 요법으로서 투여된다. 본 발명은 또한 주어진 환자에 있어서 상기 치료에 대한 치료 반응을 예측하는 방법에도 관한 것이며 따라서 이들 예측 변수 인자들 (때로 바이오마커라 칭하기도 함)에 기초하여 적용가능한 환자 부분모집단을 동정하는 것에 관한 것이기도 하다. 한 가지 방법은 통증 강도의 임상적 마커에 기초하는 것이다. 두 번째 방법은 본 발명의 화합물을 이용한 치료에 앞서 말초혈액 세포 샘플 컬렉션에서의 RNA 발현을 통한 유전자 발현 예측 바이오마커 평가에 기초한다 (즉 티로신 키나제 저해제, 비만세포 저해제 또는 c-Kit 저해제, 특히 마시티닙). 유리하게는, 본 발명은 췌장암에 걸린 환자들의 치료 방법에 관한 것으로서, 본 발명의 방법에서 상기 환자들은 티로신 키나제 저해제, 비만세포 저해제 또는 c-Kit 저해제, 특히 마시티닙에 의해 치료되며, 임의로 적어도 1종의 항종양제, 특히 겜시타빈을 조합 사용할 수 있다.

Description

예측변수 인자들을 이용하여 동정된 환자 부분모집단에서 암 치료를 위한 마시티닙의 용도{USE OF MASITINIB FOR TREATMENT OF CANCER IN PATIENT SUBPOPULATIONS IDENTIFIED USING PREDICTOR FACTORS}

종양 미세환경, 종양발생, 및 암성 통증 에 있어서 비만세포의 역할

종양발생, 질병 진행, 및 전이 과정을 통해, 국소적인 숙주 조직의 환경은 활성적인 참여 요인으로서 암세포 증식, 혈관생성, 침습 및 생존 정도를 결정짓는다. 암의 종양발생에 있어서 비만세포의 역할은 잘 이해되고 있지는 않지만, 비만세포 활성화가 종양 침습성을 증대시키는 분자들을 생산함으로써 어떤 암의 성장 및 확산을 용이하게 해준다는 가설이 가능하다. 예를 들어, 비만세포는 마우스 모델에서 췌장암 종양발생의 발병과 직접 연관지어져 왔는데, 비록 췌장암 발병에 비만 세포가 기여하는 메카니즘이 정확히 밝혀지지는 않았으나, 이 모델은 종양 미세환경 내로의 비만세포 침윤 수준이 높을 경우, 임상 결과가 좋지 않은 것으로 예측할 수 있음을 보여주었다 [Chang DZ 등, Clin Cancer Res 2011;17:7015-7023]. 따라서, 비만세포 기능의 억제는 비만세포가 충분하게 관여된 암의 성장을 제한하는데 있어서 치료적으로 유리한 것으로 입증될 수 있다. 그러나 비만세포 활성을 표적으로 삼아서 치료적 이득을 볼 수 있는 암이 정확히 어떤 암인지는 대체로 알려져 있지 않거나 이에 관하여 여전히 논란중이다. 국소적인 기질 조건에 따라 또는 방출된 매개자가 종양 세포의 증식을 도와 악성종양 세포의 세포자멸사를 유도하는지에 따라, 비만세포가 종양발생에 이로운지 아니면 종양발생을 방해하는지에 관하여 상반되는 데이터가 존재한다[(Theoharides TC, 등, Trends Immunol 2004;25:235-41); (Samoszuk M, 등, BMC Cancer 2005;21:121); (Almholt K, 등, Recent Results Cancer Res 2003;162:31-2); (Gooch JL, 등, Cancer Res 1998; 15:4199-205)]. 뿐만 아니라, 종양 성장을 억제하거나 촉진하는 비만세포의 이러한 이중적인 역할과 일치하는 내용으로서, 비만세포의 수가 많으면, 유방암, 비소세포폐암종 및 난소암에 있어서는 우수한 예후를 시사하는 것으로 알려져 왔으나[(Galinsky DS, 등 Crit Rev Oncol Hematol 2008;68:115-30); (Ribatti D, 등, Int Rev Cell Mol Biol 2009;275:89-131)], 피부암(흑색종 및 비흑색종 두 가지 모두 및 메르켈 세포 종양)[Grimbaldeston MA, 등, Br J Dermatol 2004;150:895-903); (Grimbaldeston MA, 등, J Invest Dermatol 2000;115:317-20)], 구강의 편평세포암종, 몇 가지 유형의 림프종, 및 전립선암[(Galinsky DS, 등, Crit Rev Oncol Hematol 2008;68:115-30); (Ribatti D, 등, Int Rev Cell Mol Biol 2009;275:89-131)]의 경우에는 예후가 불량한 것과 연관되어 있다. 또한 비만세포의 밀도나 비만세포의 활성화 정도 (이들 두 가지 측면이 반드시 서로 상관적인 관계도 아니다) 가 비만세포 관련 증상에서 핵심적인 고려대상인지 아닌지도 불분명한 채로 남아있다 [Hermine O, 등, PLoS ONE. 2008;3:e2266].

비만세포는 다양한 질병에 연관된 통증과 관련이 있고 암성 통증(cancer pain)에 있어서 어떤 역할을 하는 것으로 나타나고 있다. 비만세포는 통증이 주요한 증상이지만, 객관적인 질병학적 발견사항과 비례하는 것은 아닌, 즉, 해부학적 이상 단독으로는 통증을 설명할 수 없는 상태의 통증 발병과 연관되어 왔다; 이의 예로는 만성 췌장염, 간질성 방광염, 및 과민성대장 증후군을 들 수 있다. 이들 상태들 각각은 대응하는 췌장, 방광 또는 대장에서, 질병 관련 통증이 없는 환자와 비교할 때 비만세포의 수가 증가된 것과 연관지어져 왔다. 비록 암성 통증의 병인이 불분명하긴 하지만, 현재 이해되는 바로는 암 미세환경에서, 암과 면역세포들이 원발성 구심 유해수용체(primary afferent nociceptors)를 활성화 및 감작화시키는 매개자들을 생산 및 분비함을 가리키고 있다. 슈미트(Schmidt) 등은 암성 통증의 메카니즘을 검토하고 [Schmidt BL, 등, Mol Interv. 2010 Jun;10(3):164-78], 암성 통증에서 명확한 역할 역시 갖는 반응 면역계와 함께, 암 환자가 경험하는 증상들이 증식, 침습, 및 전이 동안 발생하는 세포, 조직 및 전신적 변화의 결과라고 요약하였다.

따라서, 비록 암성 통증 및 종양발생에 있어서 다양하고 간접적인 비만세포의 연관성이 입증되어 있기는 하지만(즉 비만세포 자체가 증식 중인 암 세포라는 것과 반대로), 그의 이질적이고도 분열적인 특성으로 인해 비만세포 활성을 표적으로 삼는 것이 암 환자들에 있어서 치료적으로 효과가 있을지 (좋기로는 생존 기간의 증가로서 나타내짐)에 대한 명쾌한 접근이 불가능한 실정이다. 이것은 췌장암과 같이 비만세포 증가와 관련이 있는 것으로 확립된 암의 경우에도 마찬가지이다.

암성 통증 및 약물요법 통증 제어

암성 통증의 병인은 복잡하며 여전히 잘 이해되지 않은 채로 남아있다. 암성 통증은 심할 뿐 아니라 심신을 쇠약하게 하여, 삶에 대한 기대치가 이미 낮아져 있는 환자들의 삶의 질을 극단적으로 저하시킬 수 있다. 특히 췌장암의 경우, 복부 통증과 등의 통증이 상당하며 절제가 불가능한 췌장암 환자의 거의 75%가 진단시 통증으로 고통받는 것으로 알려져 있고, 이것은 질병이 진행된 환자의 경우 90% 이상으로 증가하는 것으로 알려져 있다[Hameed M, 등, Cancers 2011, 3, 43-60]. 췌장암의 통증은 그 기원이 내장의(visceral), 체세포성, 신경병성인 것일 수 있고 조직 손상, 염증, 장폐색, 및 침윤에 의해 야기된다. 내장의 통각수용기(Visceral nociceptive) 통증은 신장(stretch), 허혈 및 염증에 특히 민감한 구조인 상복부 내장에 대한 손상에 의해 야기되는데, 일반적으로 잘 편재화되지 않은 통증을 일으킨다. 체세포 및 신경병성 통증은 종양으로부터 야기되어 주변 복막, 후복막, 뼈까지 확산될 수 있으며, 후자의 경우 요선골신경총과 같은 신경으로 확산될 수 있다.

암성 통증을 관리하는데 흔히 아편유사 진통제가 사용되는데, 이들의 작용 메카니즘은 중추신경계에 직접 작용하는 것이다. 그러나, 이것은 또한 예컨대, 변비, 기면, 현기증, 호흡 문제 및 신체적 그리고 정신적 의존성과 같은 원치 않는 부작용을 일으킬 수도 있다. 세계보건기구(WHO)는 "진통제 사다리(Analgesic ladder)" [온라인으로 접할 수 있음: www.who.int/cancer/palliative/painladder/en/ (2012. 03. 12)]라는 형태로 만성 암성 통증의 제어를 위해 투여되는 진통제 약물의 투여법에 대한 표준 접근법을 간행한 바 있다. 이 모델은 만일 통증이 생기면, 다음의 순서로 약물을 신속히 경구 투여할 것을 권장하고 있다: "가벼운 통증의 경우 파라세타몰과 같은 비아편유사제; 이어서 가벼운 통증 내지 중간 정도의 통증의 경우에는,임의로, 코데인과 같은 약한 아편유사제; 이어서 중간 내지 심한 통증에 있어서는 모르핀과 같은 강한 아편유사제를, 환자가 통증이 없어질 때까지 투여한다. 두려움과 불안을 가라앉히기 위해, 아쥬반트 약물을 사용한다. 통증이 없는 상태를 유지하기 위해서는 필요할 때마다 투여하기 보다 정기적으로, 즉 매 3-6 시간마다 투여하여야 한다". 비록 이용가능한 치료 방법론의 효능을 증가시키기 위해서는, 암에 있어서 여러가지 유형(내장, 체세포성, 및 신경병성)의 통증 생성 과정 역시도 고려해야 하는 것으로 권장되고는 있으나, 이러한 단계적 접근은 통증의 병태생리학적 경과보다는 통증의 위중도에 기초한 것이다 [Hameed M, 등, Cancers 2011, 3, 43-60].

암 환자에 있어서 암성 통증 및 삶의 질의 평가

암성 통증을 평가 및 기록하기 위해 임상의는 적절한 평가 기구 및 과정을 선택하여야 한다. 그러나, 현재로서는 일반적으로 수용되는 암성 통증 평가 툴이 전무함은 물론 심지어 평가 툴이 무엇을 평가해야하는지에 대한 합의점 조차 없는 실정이다. 그 결과 기존의 툴에 사용되는 아이템과 크기는 천차만별이어서 일반적인 통증 평가의 타당성에 영향알 미칠 수 있고 나아가 여러 연구들을 비교하는 것조차 어렵게 만들 수 있다. 통증 평가 툴은 1차원적일 수도 다차원적일 수도 있다. 문헌 검토와 전문가 그룹의 견해에 기초할 때, 암 환자들의 통증 평가 툴로서 가장 빈번히 사용되는 것은 단일 항목 1차원 툴이라는데 대체적으로 의견이 일치되고 있다. 더욱이, 통증 강도 변화의 간단한 평가 및 임상 세팅에 있어서의 통증 강도 평가에 있어서는, 시각상사척도 (VAS: Visual Analogue Scale)에 기초한 툴이 심리측정학 상으로 만족스러운 것으로 입증되었다 [Jensen, MP, 등, J Pain 2003;4(1): 2e21]. 1차원 통증 평가 툴에는 수치 등급 스케일 (0은 "무통"이고 10은 "상상할 수 있는 가장 극심한 통증"임); 구두 설명 스케일 ("무통," "가벼운 통증," "중간 통증," "심한 통증"); 또는 통증 강도를 가장 잘 나타내는 선을 환자가 가리키게끔 되어 있는 시각상사척도 (좌측에 "무통" 그리고 우측에 "상상할 수 있는 가장 극심한 통증"과 같이 앵커 표시된 100 mm 선)가 포함된다. 각각의 스케일은 그의 강약을 갖는다; 그러나, 대부분의 자가-기록형 통증 강조 측정법은 상호 강하게 연관되어 있고 특히 명확한 지침과 실시 기회가 주어진 경우, 많은 상황에서 호환적으로 사용될 수 있다.

주관적인 통증은 적어도 4가지 특이적인 인자, 즉: 통증 강도, 통증 영향(pain affect), 통증 완화(pain relief), 및 통증의 질(pain quality)로 분류될 수 있다 [Jensen, MP, 등, In: Chapman CR, Foley KM, eds.: Current and Emerging Issues in Cancer Pain: Research and Practice. New York, NY: Raven Press, 1993, pp. 193-218]. 통증 강도는 환자가 얼마나 많이 다쳤는지를 반영하며, 본 발명의 설명 목적 상 가장 중요한 통증 인자이다. 환자에 있어서, 통증 강도의 등급을 매기는 것은 크기를 평가하는 작업이다. 환자들은 대개 비교적 신속하게 통증 강도를 평가할 수 있는데, 통증 강도 측정은 통계적으로 서로 밀접하게 연관되는 경향이 있다. 따라서, 통증 강도는 대부분의 사람들이 측정하기가 비교적 쉬운 상당히 균일한 차원의 크기(dimension)인 것으로 볼 수 있다. 통증 강도를 평가하는데 가장 널리 사용되는 3 가지 방법은 구두등급척도, 시각상사척도 (VAS), 및 수치등급척도이다. 이보다 덜 흔히 사용되는 측정법으로는 거동등급척도, 그림척도, 박스척도 및 기술자 차등 n척도를 들 수 있다 [Jensen, MP, 등, In: Chapman CR, Foley KM, eds.: Current and Emerging Issues in Cancer Pain: Research and Practice. New York, NY: Raven Press, 1993, pp. 193-218].

시각상사척도는 치료 관련 결과 연구를 설정시 통증 강도를 평가하는 데 사용되는 기구 중 아마도 가장 흔히 사용되는 측정법일 것이다. VAS는 말단이 통증의 극단 (예컨대 "무통"으로부터 "가능한 가장 심한 통증"에 이르기까지)을 표지하도록 되어 있는 대개 10 cm 길이의 선으로 이루어진다. 만일 VAS가 강도를 나타내는 형용사나 숫자로 표지된 선을 따라 특정한 포인트들을 가질 경우, 이것은 통증 강도의 그래픽 등급 척도라 칭해진다. 환자들에게 선의 어떤 포인트가 그들의 통증 강도를 가장 잘 나타내는지를 질문한다. 대개, 통증 평가자는 평가 임무가 확실히 이해되도록 측정을 연습시킬 수 있다. 무통 말단으로부터 환자에 의해 표시된 마크까지의 거리가 그 환자의 통증 강도 점수이다. 통증 강도의 VAS의 타당성을 뒷받침하는 증거자료는 많이 있다. VAS는 다른 자가-기록형 통증 강도 측정법과 직접 관련되어 있을 뿐 아니라, 관찰된 통증 거동과도 관련이 있다 [Jensen, 1993 및 이 문헌에 인용된 다른 참조문헌 참고]. VAS는 대개 밀리미터로 측정되므로, 이들은 많은 수의 응답 카테고리를 갖는다. 즉, 스케일은 101 포인트를 갖도록 고려될 수 있으므로, 제한된 수의 응답 카테고리를 갖는 측정법에 비해 통증 강도의 변화에 보다 잠재적으로 보다 민감할 수 있다. 연구 결과 통증 강도의VAS는 대개(항상은 아님) 4점식 또는 5점식 구두등급척도보다, 치료 변화에 더 민감하다.

다차원 통증 평가 툴(때로는 통증 평가 설문지라고도 칭함)은 통증 강도의 기초적인 척도를 벗어나는 감각적이고 영향력이 있는 다른 정성적 요인들을 캡쳐하는 임상적 통증의 척도를 제공한다. 이론적으로, 다차원 툴은 보다 신뢰할만 하므로 시간이나 치료와 연관된 통증의 변화를 탐지하는데 있어서 잠재적으로 보다 민감할 것이다; 그러나, 이들은 1차원 툴에 비해 더 복잡하고 완성에 이르는데 더 오래 걸린다. 뿐만 아니라, 다차원 통증 또는 삶의 질 (QOL: quality-of-life) 평가 툴은 일반적으로 임상시험 설정에서 건강 관련 QOL의 변화를 평가하도록 고안된 것이므로, 이들의 점수는 대조 설정, 즉 대조 치료군들에 사용될 때만 정보를 제공할 뿐이므로, 단일의 개별적인 점수는 유용한 정보를 제공하는 것으로 간주되지 않는다. 암성 통증 평가에 사용되는 주요 다타원 통증 또는 삶의 질 (QOL) 평가의 예로는 다음을 들 수 있다: European Organization for Research and Treatment of Cancer 30-항목 코어 삶의 질 설문지 (EORTC QLQ C-30); 간이 통증 조사지(Brief Pain Inventory: BPI); 및 맥길 통증 설문지(McGill Pain Questionnaire).

특히 췌장암의 경우에는, 논란의 여지도 있고, 실무상 여전히 입증되어야 하기는 하지만, EORTC 다차원 툴이 가장 많이 적용가능하다. EORTC QLQ C-30은 암 환자들의 삶의 질을 평가하기 위해 개발된 30-항목짜리 자가-보고형 설문지이다 [Aaronson, NK 등, J Natl Cancer Inst 85(5): 365-76, 1993]. 중요한 것은, 질병의 증상, 치료 부작용 및 감정적 문제와 관련된 26 항목을 포함하는, 췌장암에 특이적인 모듈(QLQ-PAN26)을 비롯한, 질병 특이적 모듈에 의해 이것이 보강된다는 것이다. QLQ-C30 설문은 검증된 바 있지만 QLQ-PAN26 모듈은 아직 검증 전인데 이는 많은 다국적 그룹의 환자들에 있어서 여전히 심리평가 테스트를 수행할 필요가 있기 때문이다.

일반적으로, 다차원 툴의 실시와 관련된 여분의 복잡성과 환자 부담은 그 목적이 파라미터에 따라 암성 통증 강도를 측정하거나 환자를 분류하는 것일 경우 그의 장점을 상쇄한다. 따라서, 1차원 툴이, 본 발명에 있어서 통증을 설명할 목적에 이용가능한 가장 적합한 통증 평가 옵션이다.

유전자 발현 프로파일링 및 치료 부분모집단의 동정

다양한 염색체 이상을 야기하는 게놈의 변경은 모든 악성 종양의 특징이다. 유전자 돌연변이에 더해, 종양 성장은 유전자 발현의 변경된 수준에 의해 지지된다. 유전자 발현 프로파일링은 수천개의 유전자의 발현(즉 활성)을 동시에 측정하여, 특정한 생리적/병리학적 샘플의 세포 기능이나 유전자 '지문(fingerprint)'의 총체적인 지도를 만드는 것이다. 암에 있어서, 유전자 발현 프로파일링은 종양을 보다 정밀하게 분류하기 위해 사용되어 왔다; 또한, 발현 프로파일을 대조함으로써 유전자들이 지속적으로 상향조절되거나 하향조절되는 부분모집단을 동정할 수 있다. 따라서, 유전자 발현 프로파일링으로부터 유도된 정보는 잠재적으로 객관적인 진단을 가능케 하여, 생존과 관련된 유전자를 동정하고, 전악성 병변의 위험성 평가를 제공하며, 특정 치료에 대한 반응을 예측할 수 있게 해준다. 후자의 예에서, 어떤 환자의 유전자 지문이 주어졌을 때 어떤 약물에 반응할 그 환자의 확률과 같은 직접적인 임상적인 유의값에 관한 질문에 답을 줄 수 있다.

췌장암 개관

췌장은 외분비 세포(식품 소화에 중요한 효소들의 생산에 관여함)와 내분비 세포(인슐린과 같은 호르몬을 생산함)를 함유한다. 이들 외분비 세포와 내분비 세포 양자 모두가 종양을 형성할 수 있지만, 외분비 췌장에 의해 형성된 것들이 훨씬 흔하며 그 예후가 훨씬 나쁘다. 외분비 췌장 종양의 절대다수는 선암종이다. 내분비 췌장 종양(섬세포 종양이라고도 알려져 있음)은 훨씬 덜 흔하며 자연적으로는 대개 양성이다.

외분비성 췌장의 암(이하 췌장암이라 부른다)은 목숨을 위협하는 위중한 병태이다. 대부분의 경우, 이 질병의 조기 단계는 무증상이며 외과수술에 적합한 췌장암은 20% 미만이다. 종양 절제술을 받는 환자들 중, 20%만이 5년간 생존한다. 췌장암의 조기 진단은 상당히 어려운데 이는 증상이 다양하고 비특이적이기 때문이다. 증상은 외분비나 내분비 기능의 파괴보다는 체중 효과에 의해 일어나며, 종양의 크기와 위치, 그리고 전이의 존부에 좌우된다. 췌장의 헤드 부분에서 시작하는 암은 총담관 근방에 있다. 이 암들이 크기가 상당히 작은 동안 담관을 압축하여, 황달을 일으킬 수 있으므로 이 종양들이 조기 단계에서 발견될 수 있다. 췌장의 몸통이나 꼬리 부분에서 시작되는 암은 췌장을 통해 확산될 때까지 담관을 압박하지 않는다. 이때 쯤이면, 이 암은 췌장 전체는 물론 때로는 간까지 퍼져, 황달을 일으킬 수 있다. 췌장암과 흔히 관련된 모든 증상들은 다양한 다른 원인을 가질 수 있을 뿐 아니라, 췌장암이 흔히 진행 단계에서 관찰되는 결과와 함께 진단을 복잡하게 만든다. 또한 침습성 췌장암과 전이성 췌장암은 화학요법과 방사능 요법의 기존 치료에 잘 반응하지 않으며, 높은 수준의 탄수화물 항원 19-9 (CA 19-9), 및 이스턴 코오퍼러티브 온콜로지 그룹(Eastern Cooperative Oncology Group: ECOG) 상태 ≥ 2 역시 이러한 불량한 예후와 연관되어 있다. 사망률은 지난 수십년간 여전히 높은 채로 남아있고, 표준 치료를 받은 환자들의 진단 후 중앙생존(median survavla) 기간은 전이암과 국소 진행암 환자들에서 각각 3-6개월 및 9-12개월 정도이다. 전체 5년 생존율은 5% 미만이다.

선암종 췌장암의 치료

췌장암의 치료는 표 1에 설명된 바와 같이, 암의 단계에 따라 달라진다. 이 질병이 췌장에 국한되어 주변 혈관으로부터 확실히 분리된 경우 (즉, 국소적이고 절제가능한 경우)에는, 치료법으로서 외과수술을 선택하고 수술후 화학요법 및/또는 방사선 요법을 실시한다. 만일 이 질환이 매립형이거나 주변 혈관을 압박하거나 또는 인접 기관으로 확산된 경우 (즉,국소 진행형이고 절제불가능한 경우)에는, 화학요법 및/또는 방사선요법이 권장된다. 드문 경우로서, 환자가 치료에 잘 반응하면, 나중에 종양을 외과적으로 도려낼 수도 있다. 질환이 원거리의 장기까지 확산된 경우 (즉, 전이성), 화학요법이 제안된다. 대부분의 경우, 이러한 치료가 완치(cure)를 나타내는 것은 아니다.

표 1: 췌장암의 단계 및 치료

화학요법은 절제불가능한 진행된 암(국소 진행형 또는 전이성) 환자에서 이용될 수 있고 국소 질병 환자에서는 외과 수술 후 또는 심지어 수술에 앞서 종양을 수축시키기 위해 신보강 화학요법으로서도 이용될 수 있다. 5-플루오로우라실(5-FU)에 비해 겜시타빈(Gemzar

, Lilly사, 프랑스)이 생존 연장과 증상 개선에 더 효과가 있다는 무작위 연구 결과가 나오기 전까지, 지난 수십년간, 5-플루오로우라실(5-FU)은 가장 널리 사용되어 온 화학요법 약물이었다. 시티딘의 뉴클레오사이드 유사체인 겜시타빈은 이제 국소 진행형의 절제불가능한 췌장암 또는 전이성 췌장 선암종 환자에 있어서 표준 전신 치료법으로서 확립되었다. 그러나, 단일 제제로서의 겜시타빈의 효능은 그다지 높지 않아서 무작위 시험에서는 중앙 생존율(median survival)이 약 6개월이고, 12개월 생존율은 약 20%에 불과하다. 항대사물질 겜시타빈 (CAS 번호 95058-81-4; (4-아미노-1-[3,3-디플루오로-4-히드록시-5-(히드록시메틸) 테트라히드로퓨란-2-일]-1H-피리미딘-2-온)은 DNA 복제 중에 시티딘을 대체하여 암 세포에서 세포자멸사를 일으킨다. 겜시타빈은 다음의 화학식을 갖는다:

현재까지, 겜시타빈과 세포독성제 및/또는 생물학적 표적 화합물과의 무수한 조합에 관한 임상시험이 시도되었으나, 그 결과는 거의 전부 실망스러워, 겜시타빈 단일요법과 비교해 장점이 거의 또는 전무한 실정이다. 췌장암의 원인은 잘 이해되고 있지는 않으나 췌장암 세포와 정상 세포 간의 차이점들이 밝혀짐에 따라, 새로운 약물들에 의해 특이적인 표적만을 공격함으로써 이러한 차이점을 이용하려 시도되고 있다. 따라서, 성장인자의 역할에 점점 그 관심이 고조되고 있다. 상피성장인자(EGF), 혈소판-유도형 성장인자(PDGF), 섬유모세포성장인자 (FGF), 및 혈관내피성장인자(VEGF)와 같은 몇가지 성장인자들과 이들의 수용체들은 췌장암이 진행되는 동안 과발현된다. 세포질 티로신 키나제의 제어불가능한 발현 역시도 저조한 예후와 화학내성과 연관지어져 왔다. 특히, 췌장암에 있어서 겜시타빈 내성은 전이와 관련된 단백질인 국소부착 키나제 (FAK)와 종종 연관되어 있고; SRC 및 Lyn을 비롯한 Src 패밀리 키나제(SFK)의 증가된 발현 역시도 많은 인간 암세포주 및 종양 조직에서 보고된 바 있다. 뿐만 아니라, 비만세포에 의한 침윤을 비롯하여, 염증 세포의 동원이 종양 침습성을 증대시키는 분자들의 생산을 통해 암의 성장 및 확산을 용이하게 한다는 증거들이 나오고 있다.

표피성장인자 수용체(EGFR)는 엘로티닙(Tarceva

)을 비롯하여 개발 중인 몇가지 약물들의 표적이 되고 있는데 상기 엘로티닙과 겜시타빈의 조합은 절제불가능한 췌장암 환자들에 있어 제1선의 치료제로서 승인된 바 있다. 이 조합은 임상시험에서 생존율을 약간 더 연장시키는 것으로, 즉, 중앙 OS를 겜시타빈 단독요법(5.91 개월)에 비해 2주일 더 길게 (6.24 개월) 연장시키고, 1개월 생존율을 23%로 하는 것으로 나타났다 (참조, 겜시타빈 단독요법 치료군의 경우 17%임; p=0.023) [Moore MJ, 등, J Clin Oncol. 2007 May 20;25(15):1960-6].

전이성 췌장암 환자에 있어서 제1선 치료법으로서 겜시타빈에 비해 4가지 약물조합에 의한 화학요법(FOLFIRINOX) (류코보린 칼슘, 플루오로우라실, 이리노테칸 염산염 및 옥살리플라틴으로 구성됨)의 효능과 안전성을 알아보기 위해 2/3상 멀티센터 무작위 시험이 수행되었다 [Conroy T, 등, N Engl J Med. 2011 May 12;364(19):1817-25]. 이 조합 내의 각각의 약물들은 FDA에 의해 암이나 암 관련 병태를 치료하는데 승인된 것들이다. 폴피리녹스 요법으로 처리된 환자들은 현행의 표준요법인 겜시타빈으로 치료된 환자들에 비해 약 4개월 더 오래 생존하였다(11.1 개월 대 6.8 개월). 객관적인 반응율은 폴피리녹스 치료 환자에서 31.6%였고 겜시타빈 치료 환자에서는 9.4%였다. 전반적으로, 폴피리녹스는 생존기간 면에서는 유리하지만 독성 역시 눈에 띄게 증가하는 것으로 나타났다. 또한, 이 연구 설계에는 몇가지 가능한 모집단 편향 문제와, 블라인드형 연구 디자인이 아님에 따른 가능한 교란 효과 문제가 존재한다. 예를 들어, 이 연구 디자인은 우수한 수행도(ECOG 상태 점수 0 또는 1)를 나타내는 환자들만을 선택하였고, 이리노테칸-유도된 독성의 위험성 증가로 인해, 빌리루빈 수준이 높은 환자 (전형적으로 황달로 나타나며 췌장의 두부에서 췌장암 환자에게 흔히 진단되는 징후임)는 배제되었다. 겜시타빈과 비교할 때 폴피리녹스의 보다 큰 독성과 이러한 치료 관리 제약으로 인해, 이 치료법을 관용할 수 없는, 예후가 가장 안 좋은 환자들을 비롯하여, 전체적인 췌장암 모집단의 상당한 비율이 폴피리녹스 사용으로부터 너무나도 쉽게 배제되게 된다. 따라서, 폴피리녹스는 76세 이하로서, 우수한 수행도를 나타내며 심장 허혈이 없고 빌리루빈 수치가 정상이거나 거의 정상인 전이성 췌장암 환자들에 있어서만 제1선 치료 옵션으로 적합할 뿐이다.

겜시타빈에 대한 췌장암 세포의 마시티닙 시험관내(재)감작화

본 발명자들은 앞서 마시티닙과 뉴클레오사이드 유사체인 겜시타빈(Gemzar

, Eli Lilly 및 Company)과의 조합이 인간 췌장 선암종의 성장을 저해함을 발견한 바 있다. 본 발명자들의 시험관내 및 생체내 연구는 마시티닙이:

● 다양한 암세포주들을 겜시타빈에 대해 감작화시키고 [Thamm DH, 등 2011 The Veterinary Journal, doi:10.1016/j.tvjl.2011.01.001]

● 겜시타빈-무반응성 췌장암 세포주들을 감작화시키며 [Humbert M, 등 (2010) PLoS ONE 5(3): e9430. doi:10.1371/journal.pone.0009430]

● 인간 췌장암의 Nog-SCID 마우스 모델에서 마시티닙 플러스 겜시타빈 조합의 항증식 활성을 입증하였음 [Humbert M, 등 (2010) PLoS ONE 5(3): e9430. doi:10.1371/journal.pone.0009430]

을 보여준 바 있다.

이러한 연구 결과는 마시티닙이 아마도 화학감작화를 통해 생체내 겜시타빈의 항증식 활성을 증강시킬 수 있다는 가설을 뒷받침하는 것이다. 이 이론은 인간 2상 연구 결과에 의해 더욱 보강되었는데 이 임상 연구에서 마시티닙 (9 mg/kg/일) 플러스 겜시타빈의 조합이 투여된 진행된 췌장암 환자들은 전체 모집단에서 겜시타빈으로 단독 치료된 환자들에 비해 암 진행에 이르는 중앙시간이 개선된 것으로 나타났다 [Mitry E, 등 2010. Cancer 화학요법 및 Pharmacology 66, 395].

발명의 목적

본 발명의 목적은 암 치료를 위한 활성 성분을 제공하는데 있어서 기술적 문제를 해결하는데 있다.

본 발명의 목적은 또한 암 치료를 위한 종래방법을 개선하여 활성 성분을 제공하는데 있어서의 기술적 문제를 해결하는 데 있다.

본 발명의 목적은 적절한 투여량, 투여 경로 및 일일 섭취량에 의해, 암의 효과적인 치료법을 제공하는 데 있다.

본 발명의 목적은 주어진 환자에 있어서 상기 치료에 대한 치료 반응을 예측하는데 있어서의 기술적 문제를 해소하고 그에 따라 이러한 예측변수 인자들에 기초하여 적용가능한 환자 부분모집단을 동정하는데 있다.

이러한 예측변수 인자들 중 하나는 통증 강도의 임상적 마커에 기초한다. 따라서, 본 발명은 통증과 연관된 암의 치료 또는 질병 관련 통증의 치료에 있어서 아편유사 진통제의 요구사항과 관련한 종래기술 방법을 개선시키는 활성 성분의 제공에 있어서의 기술적 문제를 해결함을 목적으로 한다.

또 다른 예측변수 인자는 말초혈액 샘플에서의 RNA 발현 분석을 통한 유전자 발현 프로파일링에 기초한다. 따라서, 본 발명은 특정 유전자 또는 유전자 발현 조합(예컨대 유전자/전사체 지문)을 산생하는 환자들에 있어서 암 치료를 위한 종래방법을 개선시켜주는 활성 성분의 제공과 관련한 기술적 문제를 해결하는 것을 목적으로 한다.

겜시타빈에 기초한 조합 화학요법을 개발하기 위한 여러 시도에도 불구하고, 췌장암은 여전히 화학내성적이고 고도로 공격적인 종양으로 남아있다. 진행된 췌장암의 치료는 질병 관련 증상과 생존기간에 대한 화학요법-유도된 경감 효과 관점에서 중요한 당면과제 인채로 남아있다. 폴피리녹스 투여 요법은 조합요법의 개발을 위한 대안적인 중추적 방법을 제공하지만 높은 독성으로 인해 대다수의 환자들에게는 아마도 그 사용이 제한될 것이다. 췌장암, 특히 통증과 연관된 췌장암의 효과적인 치료 방법의 부재와 불량한 예후가 계속됨에 따라, 유의적으로 독성을 증가시킴이 없이 췌장암에 걸린 환자들의 임상적 관리를 향상시키는 보다 효과적인 치료 전략에 대한 충족되지 않은 의학적 필요성이 강조되고 있다. 췌장암에 걸린 환자들의 제한적인 기대여명을 고려할 때, 생존기간 또는 삶의 질 개선은 매우 의미있는 목표이다. 또한, 이러한 두 가지 측면을 모두 동시에 개선시킬 수 있는 치료법은 특히나 더욱 가치있을 것이다.

따라서, 본 발명은 진행된 선암종 췌장암의 치료를 위한 종래방법을 개선시키는 활성성분을 제공이라는 기술적 과제를 해결함을 목적으로 한다.

본 발명은 또한 통증과 연관된 진행된 선암종 췌장암의 치료 또는 질병 관련 통증의 치료에 있어서 아편유사 진통제의 요구사항과 관련한 종래기술 방법을 개선시키는 활성 성분의 제공에 있어서의 기술적 문제를 해결함을 목적으로 한다.

본 발명은 또한 특정 유전자 또는 유전자 발현 예측변수 인자들(즉 유전자/전사체 지문)을 산생하는 진행된 선암종 췌장암 환자의 치료를 위하여 종래방법을 개선하는 활성 성분의 제공과 관련한 기술적 문제를 해결하는 것을 목적으로 한다.

발명의 개요

본 발명은 인간 환자에 있어서 암의 치료방법에 관한 것으로, 상기 방법은 치료를 필요로 하는 인간 환자에게 티로신 키나제 저해제, 비만세포 저해제 또는 c-Kit 저해제, 특히 마시티닙 또는 약학적으로 허용가능한 그의 염을, 임의로 적어도 1종의 항 종양제와 조합하여 투여하는 것을 포함한다.

본 발명에서 "항종양제(antineoplastic agent)"라 함은, 암 치료에 사용되는 약제를 가리킨다. 예를 들어, 호주 약전 n⁰302 (Oct 1992)의 38-39 페이지 및 41-43 페이지; 또는 미국식품의약안전청(USFDA)에 의해 종양 치료에 승인된 약물 목록; 또는 National Institute for Occupational Safety and Health (NIOSH)가 발간한 항종양제 목록 및 Healthcare Settings 2012의 기타 유해약물 (DHHS Publication Number 2012-150)에 설명된 것들 (상기 문헌들은 본 발명에 참조 병합된다), 알킬화제, 항유사분열제, 항대사산물제, I형 항토포이소머라제 약물, 백금유사체, 항생제, 호르몬제, 항혈관형성제, 유전자독성제, 세포독성제, 생물제제, 또는 부가적인 티로신 키나제 저해제를 들 수 있다.

특히, 상기 항종양제들의 비제한적인 예로는 다음을 들 수 있다: 아바렐릭스, 아비라테론 아세테이트, 알데스류킨, 알트레타민, 아나스트로졸, 삼산화비소, 아스파라기나제, 악시티닙, 아자시티딘, 벤다무스틴 염산염, 베바시주맙, 벡사로텐, 비칼루타미드, 레오마이신, 보르테조밉, 브렌툭시맙 베도틴, 부술판, 카바지탁셀, 캄파트, 캄토사르, 카페시타빈, 카르보플라틴, 카르필조밉, 카르무스틴, 세툭시맙, 클로람부실, 시스플라틴, 클라드리빈(2CDA), 클로파라빈, 크리조티닙, 시클로포스파미드, 시타라빈(ARA-C), 시토신 아라비노사이드, 다카르바진, 닥티오마이신, 다사티닙, 다우노루비신, 데시티빈, 데가렐릭스, 데니류킨, 도세탁셀, 독소루비신, 에피루비신, 에리불린 메실레이트, 엘로티닙, 에스트라무스틴 포스페이트, 에토포시드, 에베롤리무스, 엑세메스탄, 플룩스우리딘, 플루다라빈, 플루오로-5-우라실(5 플루오로우라실), 플루오로우리딘-데속시리보스, 플루타미드, 풀베스트란트, 게피티닙, 겜시타빈, 겜투주맙 오조가미신, 히드록시우레아, 이브리투모맙 티욱세탄, 이다루비신, 이포스파미드, 이마티닙, 이필리무맙, 이리노테칸,익사베필론, 라파티닙, 레트로졸, 류코보린, 류프롤리드 아세테이트, 로무스틴, 메클로레타민, 메게스트롤, 멜팔란, 메르캅토퓨린, 메토트렉세이트, 미토마이신, 미토탄, 미토잔트론, 텔라라빈, 닐로티닙,, 닐루타미드, 놀바덱스, 오파투무맙, 옥살리플라틴, 파클리탁셀, 파니투무맙, 파조파닙, 페가스파라가제, peg인터페론, α-2b, 페메트렉세드, 펜토스타틴, 퍼투주맙, 플레릭사포, 프랄라트렉세이트, 프로카르바진, 프로류킨, 로미뎁신, 사파시타빈, 시풀레우셀-T, 소라페닙, 스트렙토조신, 수니티닙, 타목시펜, 테모졸로미드, 템시롤리무스, 테니포시드, 테스토락톤, 데자시타빈, 티오구아닌, 티오테파, 토포테칸, 토르미펜 시트레이트, 트라스투주맙, 트립토렐린, 트록사시타빈, 발루비신, 발스타르, 반데타닙, 베무라페닙, 빈블라스틴, 빈크리스틴 술페이트, 비노렐빈, 비스모데깁, 보리노스타트, 젤로다, 지브-아플리베르셉트, 졸레드론산, FOLFOX (옥살리플라틴 + 5 플루오로우라실 + 폴린산), FOLFIRI (이리노테칸 + 5 플루오로우라실 + 폴린산), 폴피리녹스 (옥살리플라틴 + 이리노테칸 + 5 플루오로우라실 + 폴린산), 및 이들 항종양제들의 조합.

본 발명에서 "암의 치료"라는 표현은, 다음으로부터 선택되는 (그러나 이에 한정되지 않음) 암의 치료를 필요로 하는 환자와 관련하여 사용된다: 급성림프구 백혈병(ALL), acute 골수성 백혈병 (AML), 부신피질암종, 항문암, 기저세포암종, 담관암, 방광암, 골암, 뇌간교종, 뇌종양, 유방암, 자궁경부암, 만성 림프구 백혈병(CLL), 만성 골수성 백혈병(CML), 대장암(CRC), 자궁내막암, 식도암, eye cancer, 담낭암, 위암, 위장관기질종양 (GIST), 다형교모세포종 (GBM), 털세포 백혈병, 두경부암, 심장암, 간세포(간)암종 (HCC), 호지킨 림프종 및 비-호지킨 림프종s, 카포시 육종, 후두암, 비만세포증, 흑색종, 골수섬유증, 골수형성이상 증후군 (MDS), 다발골수종, 비소세포폐암종 (NSCLC), 폐암(소세포), 흑색종, 코인두암종, 신경내분비종, 신경모세포종, 구강암, 임인두암, 난소암, 췌장암, 부비동 및 비강암, 부갑상선암, 음경암, 인두암, 뇌하수체 선종, 전립선암, 직장암, 신장세포(신장)암종 (RCC), 침샘암, 피부암 (비흑색종), 소장암, 소림프구림프종 (SSL), 연조직 육종, 편평세포암종, T 세포 림프종, 고환암, 구협암, 갑상선암, 삼중음성 유방암, 요도암, 및 자궁암. .

일 구체예에서, 본 발명은 티로신 키나제 저해제 또는 비만세포 저해제가 티로신 키나제: c-Kit, PDGFR, Lyn, Fyn, 및 DDR1로부터 선택된 키나아제의 활성의 저해제인 것인, 전술한 방법에 관한 것이다.

특정 구체예에서, 티로신 키나제 저해제, 비만세포 저해제 또는 c-Kit 저해제는 마시티닙 또는 약학적으로 허용가능한 그의 염, 특히 메실레이트 염이다.

본 발명에서 "예측변수 인자(predictor factor)" 또는 "바이오마커(biomarker)"라는 용어는, 치료적 개재에 대한 약리학적 반응 또는 정상적인 생물학적 프로세스, 또는 병원성 프로세스의 표시자로서 평가뇌는 단일 특징 또는 특징들의 그룹을 가리키는 것이다. 본 발명과 관련하여, "예측변수 인자" 또는 "바이오마커"는 서술적(predicative) 바이오마커, 예후 바이오마커, 분자 마커, 유전자 마커, 유전자 예측변수 세트, 유전자 지문, 전사체 지문, 유전자 프린트, 유전자 서명, 종양 마커, 암 마커, 생물학적 마커, 생화학적 마커 및 생물학적 표시자를 가리키는 것이기도 하다.

일구체예에 따라, 본 발명은 상기 환자가 통증 강도의 예측변수 인자에 기초하여 치료되도록 초기에 선택되는 것인, 전술한 방법에 관한 것이다.

따라서, 일 구체예에서, 본 발명은 인간 환자에서 통증과 연관된 암 또는 통증 관련 암의 치료를 위해 아편유사제의 투여를 필요로 하는 암의 치료방법에 관한 것으로서, 티로신 키나제 저해제, 비만세포 저해제 또는 c-Kit 저해제, 특히 마시티닙 또는 약학적으로 허용가능한 그의 염을, 임의로 적어도 1종의 항종양제와 임의로 조합하여 환자에게 투여하는 치료방법에 관한 것이다.

또 다른 구체예에서, 본 발명은 상기 환자가 통증과 연관된 암에 걸리거나 질병 관련 통증의 치료를 위해 아편유사진통제의 투여를 필요로 하는 암에 걸린 환자를 치료하는 전술한 방법으로서, 여기서 '통증'은 (적절한) 통증 강도 평가 툴을 이용하여 탐지되는 바와 같이, 0이 아닌(non-zero) 통증 강도가 적어도 1회 일어난 것으로 정의된다. 따라서, 통증 강도의 예측변수 인자에 따라, 그리고 그 밖의 독립적인 예측변수 인자의 부재 하에서는, 통증 또는 질병 관련 통증의 치료를 위한 아편유사제의 사용 필요성과 관련이 없는 암에 걸린 환자에 대해 상기 치료법을 실시하는 것은 권장되지 않음을 시사한다.

또 다른 구체예에서, 본 발명은 상기 환자가 통증과 연관된 암에 걸리거나 질병 관련 통증의 치료를 위해 아편유사진통제의 투여를 필요로 하는 암에 걸린 환자이고, '통증'은 비제한적인 예로서 구두등급척도, 시각상사척도 (VAS), 수치등급척도, 거동등급척도, 그림척도, 박스척도, 기술자 차등 n척도, European Organization for Research and Treatment of Cancer의 췌장암에 있어서의 삶의 질 설문 (EORTC QLQ-PAN26), Brief Pain Inventory (BPI), 또는 McGill Pain Questionnaire를 포함하는 (적절한) 통증 강도 평가 툴에 따라 정의되는 것인, 전술한 방법에 관한 것이다.

일 구체예에서, 본 발명은 통증이 질병 관련 통증 치료를 위해 아편유사 진통제의 투여를 필요로 하는 통증과 관련된 암에 환자가 걸려 있고, 상기 '통증'은 시각상사척도 (VAS) 통증 강도 점수가 5 보다 크고 (예컨대 100 mm 스케일에서 측정시 VAS >5 mm, 또는 5%); 또는 VAS 통증 강도 점수가 10 보다 크거나 (예컨대 100 mm 스케일에서 측정시 VAS >10 mm, 또는 10%); 또는 심지어 VAS 통증 강도 점수가 20 보다 큰 것인(예컨대 100 mm 스케일에서 측정시 VAS >20 mm, 또는 20%) 통증이 적어도 1회 일어난 것으로 정의되는 것인 전술한 방법에 관한 것이다.

또 다른 구체예에서, 본 발명은 상기 환자가 통증과 연관되거나 질병 관련 통증의 치료를 위해 아편유사 진통제의 투여가 요구되는 암에 걸린 환자이고, '통증'은 상기 VAS 통증 강도 역치의 동등한 측정값이 적어도 1회 발생하는 것 또는 다차원 또는 분류된 통증 평가 툴에 의한 통증 강도 등급에 따라 보통 내지 참을 수 없는 통증이 적어도 1회 발생한 것으로 보고된 것인 전술한 방법에 관한 것이다.

또 다른 구체예에서, 본 발명은 상기 환자가 통증과 연관되거나 또는 질병 관련 통증의 치료를 위해 아편유사 진통제의 투여를 필요로 하는 췌장암에 걸린 환자이고, 통증은 시각상사척도 (VAS) 통증 강도 점수가 20보다 큰 것인 (예컨대 100 mm 스케일에서 측정시 VAS ≥ 20 mm, 또는 20%), 상기 정의된 바와 같은 방법에 관한 것이다.

일 구체예에서, 본 발명은 상기 환자가 유전자 발현 예측변수 인자에 기초한 치료를 위해 처음에 선택된 것인 상기 정의된 방법에 관한 것이다.

일 구체예에서, 상기 유전자 발현 예측변수 인자들은 환자의 혈액 샘플, 좋기로는 상기 환자의 전체 말초혈액 샘플로부터 유도되는 것이 바람직하다. 말초 혈액은 심장, 동맥, 모세관 및 정맥을 통해 순환하는 혈액이다. "전혈(whole blooed)"이라는 용어는 혈액의 특정 성분을 분리하여 얻어진 혈액의 분획과 대비되는 개념으로 사용된다. 따라서, 특정한 일 구체예에서 상기 유전자 발현 예측변수 인자들은 상기 티로신 키나제 저해제, 비만세포 저해제 또는 c-Kit 저해제, 특히 마시티닙 또는 약학적으로 허용가능한 그의 염을 이용한 치료에 앞서 말초 혈액 세포 샘플로부터 유도된다.

따라서, 일 구체예에서, 본 발명은 임의로 적어도 1종의 항종양제와 조합된 티로신 키나제 저해제, 비만세포 저해제 또는 c-Kit 저해제, 특히 마시티닙 또는 약학적으로 허용가능한 그의 염을 환자에게 투여하되, 상기 환자는 다음 중 적어도 1종의 유전자들의 말초혈액이 상향 또는 하향조절된 것인, 암의 치료방법에 관한 것이다: ACOX-1, TNFRSFS10B, RPS23, ABCC3, LYN, HIF1αLPHA, ABCC1, IGJ, UBE2H, 또는 PARP-2, 또는 이들의 동족체(homologous).

주어진 환자에 있어서 주어진 유전자의 상향조절 또는 하향조절은 1 이상의 레퍼런스 유전자와 연관된 유전자 발현 수준인 델타 사이클 역치(Delta Cycle Threshold: DCt)값으로서 정량화된다. 이러한 레퍼런스 유전자 또는 하우스키핑 유전자는 일정한 발현수준을 갖는 것으로 특징지어지며 따라서 내부 대조군(internal control) 역할을 한다. DCt 값은 유전자 발현 수준에 역비례한다; 따라서 상향조절된 유전자의 경우 DCt 값이 낮을수록 발현 수준이 더 높다는 것을 나타내는 반면, 하향조절되는 유전자의 경우에는, DCt 값이 높을수록 발현 수준은 낮은 것이다. 규정된 델타 사이클 역치 컷-오프값이 예컨대 ±10% 또는 심지어 ±25%의 범위로 약간 변형된 것으로 시사되며, 최적의 역치는 테스트된 컷-오프값 근방에 위치하고 연구된 환자 모집단은 일반적인 암 모집단의 단지 대표적인 코호트였음을 반영하는 것이다.

"상동적(homologous)"이라는 용어는 어떤 폴리뉴클레오타이드 서열이 해당 유전자 서열(전장)에 대해 적어도 80%, 좋기로는 85%, 더욱 좋기로는 90%, 및 더더욱 좋기로는 99%의 서열 동일성을 갖는 것으로 정의된다. 동일성의 정도는 2개의 서열들 간의 서열 동일성을 가리키는 것이다. 동일성(identity)은 비교 목적으로 정렬될 수 있는 각 서열의 어떤 위치를 비교함으로써 구할 수 있다. 비교대상 서열들의 대등한 위치가 동일한 염기에 의해 점하여질 경우, 이 분자들은 그 위치에서 동일한 것이다. 다양한 정렬 알고리듬 및/또는 프로그램이 FASTA 및 BLAST를 비롯하여 2가지 서열들의 상동성을 탐지하는데 이용될 수 있다.

또 다른 구체예에서, 본 발명은 상기 환자가 ACOX-1, TNFRSFS10B, RPS23, ABCC3, LYN, HIF1α, ABCC1, IGJ, UBE2H, 및 PARP-2로부터 선택되는 적어도 2개의 유전자의 동시적인 상향조절 또는 하향조절을 갖는 것인, 전술한 방법에 관한 것이다. 예를 들어, 이중-유전자 조합(dual-gene combinations)의 비제한적인 예로는: 동시적인 유전자 ACOX-1 및 TNFRSF10B의 상향조절; 동시적인 유전자 RPS23의 하향조절과 유전자 ACOX-1의 상향조절; 동시적인 유전자 ABCC3 및 LYN의 상향조절; 동시적인 유전자 HIF1A 및 TNFRSF10B의 상향조절; 동시적인 유전자 ABCC1 및 IGJ의 하향조절; 동시적인 유전자 UBE2H 및 PARP-2의 하향조절을 들 수 있다. 개별적으로, 이들 조절 유전자 쌍들은 "유전자 발현 예측변수 인자들"이라 칭해지며, 집합적으로 이들은 '유전자 지문' 또는 '전사체 지문'이라 칭해진다. 조절된 유전자의 6개 쌍들이 '유전자/전사체 지문'을 구성한다. 적어도 하나의 유전자 발현 예측변수 인자를 갖는 것으로 동정된 환자들은 '유전자/전사체 지문'을 내는 것으로 여거진다. 여타의 독립적인 예측변수 인자가 부재할 경우, 상기 유전자/전사체 지문이 결여된 환자를 치료하는 것은 권장되지 않는다.

일 구체예에서, 유전자 ACOX-1 및 TNFRSF10B의 동시적인 상향조절은 환자 델타 사이클 역치값이 ACOX-1의 경우 3.81 이하이고 TNFRSF10B의 경우 7.63 이하인 것에 대응하며; 더욱 좋기로는 환자 델타 사이클 역치값이 ACOX-1의 경우 3.36 이하이고, TNFRSF10B의 경우 6.71 이하에 대응하고; 더더욱 좋기로는 환자 델타 사이클 역치값이 ACOX-1의 경우 3.05 이하이고 TNFRSF10B의 경우 6.1 이하인 것에 대응하는 것이다.

일 구체예에서, 동시적인 유전자 RPS23의 하향조절과 유전자 ACOX-1의 상향조절은 환자 델타 사이클 역치값이 RPS23의 경우 0.26을 초과하고 ACOX-1의 경우 3.81 이하이며; 더욱 좋기로는 환자 델타 사이클 역치값이 RPS23의 경우 0.32를 초과하고 ACOX-1의 경우 3.36 이하이며; 및 더더욱 좋기로는 환자 델타 사이클 역치값이 RPS23의 경우 0.35를 초과하고 ACOX-1의 경우 3.05 이하인 것에 대응한다.

일 구체예에서, 유전자 ABCC3와 LYN의 동시적인 상향조절은 환자 델타 사이클 역치값이 ABCC3의 경우 5.38 이하이고 LYN의 경우 2.06 이하이며; 더욱 좋기로환자 델타 사이클 역치값이 ABCC3의 경우 4.73 이하이고 LYN의 경우 1.82 이하이며; 및 더더욱 좋기로는 환자 델타 사이클 역치값이 ABCC3의 경우 4.3 이하이고 LYN의 경우 1.65 이하인 것에 대응한다.

일 구체예에서, 유전자 HIF1A와 TNFRSF10B의 동시적인 상향조절은 환자 델타 사이클 역치값이 HIF1A의 경우 4.94 이하이고 TNFRSF10B의 경우 7.06 이하이며; 더욱 좋기로는 환자 델타 사이클 역치값이 HIF1A의 경우 4.35 이하이고 TNFRSF10B의 경우 6.22 이하이며; 더더욱 좋기로는 환자 델타 사이클 역치값이 HIF1A의 경우 3.95 이하이고 TNFRSF10B의 경우 5.65 이하인 것에 대응한다.

일 구체예에서, 유전자 ABCC1와 IGJ의 동시적인 하향조절은 환자 델타 사이클 역치값이 ABCC1의 경우 2.63을 초과하고 IGJ의 경우 5.29 이하이며; 더욱 좋기로는 환자 델타 사이클 역치값이 ABCC1의 경우 3.15를 초과하고 IGJ의 경우 6.35 이하이며; 더더욱 좋기로는 환자 델타 사이클 역치값이 ABCC1의 경우 3.5를 초과하고 IGJ의 경우 7.05 이하인 것에 대응한다.

일 구체예에서, 유전자 UBE2H와 PARP-2의 동시적인 하향조절은 환자 델타 사이클 역치값이 UBE2H의 경우 2.78을 초과하고 PARP-2의 경우 5.33을 초과하며; 더욱 좋기로는 환자 델타 사이클 역치값이 UBE2H의 경우 3.33을 초과하고 PARP-2의 경우 6.39를 초과하며; 더더욱 좋기로는 환자 델타 사이클 역치값이 UBE2H의 경우 3.7을 초과하고 PARP-2의 경우 7.1을 초과하는 것에 대응한다.

또 다른 구체예에서, 본 발명은 임의로 적어도 1종의 항종양제와 임의 조합된 티로신 키나제 저해제, 비만세포 저해제 또는 c-Kit 저해제, 특히 마시티닙 또는 약학적으로 허용가능한 그의 염을 환자에게 투여하되, 상기 환자는 유전자 ACOX-1 또는 그의 동족체가 말초혈액에서 상향조절된 환자인 것인 암의 치료방법에 관한 것이다.

일 구체예에서, 유전자 ACOX-1의 상향조절은 환자 델타 사이클 역치값이 3.81 이하이고; 더욱 좋기로는 3.36 이하이며; 더더욱 좋기로는 3.05 이하인 것에 대응한다.

일 구체예에서, 본 발명은 마시티닙을 1일 투여량 4.5 내지 12.0 mg/kg/일으로 투여하되, 바람직한 구체예에서 암환자에게 출발 1일 투여량을 6.0 내지 7.5 mg/kg/일로 하여 투여하는 것인 전술한 방법에 관한 것이다.

일 구체예에서, 본 발명은 마시티닙을 1.5 mg/kg/일씩 증분시켜 최대 12.0 mg/kg/일의 투여량으로 투여하는 전술한 방법에 관한 것이다.

일 구체예에서, 본 발명은 상기 티로신 키나제 저해제, 비만세포 저해제 또는 c-Kit 저해제, 특히 마시티닙 또는 약학적으로 허용가능한 그의 염을 경구 투여하는 전술한 방법에 관한 것이다.

일 구체예에서, 본 발명은 상기 티로신 키나제 저해제, 비만세포 저해제 또는 c-Kit 저해제, 특히 마시티닙 또는 약학적으로 허용가능한 그의 염을 1일 2회 투여하는 전술한 방법에 관한 것이다.

일 구체예에서, 본 발명은 상기 티로신 키나제 저해제, 비만세포 저해제 또는 c-Kit 저해제, 특히 마시티닙 또는 약학적으로 허용가능한 그의 염을 3개월 넘게 장기간 투여하는 것을 포함하는 전술한 방법에 관한 것이다.

일 구체예에서, 본 발명은 상기 티로신 키나제 저해제, 비만세포 저해제 또는 c-Kit 저해제, 특히 마시티닙 또는 약학적으로 허용가능한 그의 염을 네오아쥬반트, 아주반트, 동시요법으로서 적어도 1종의 항종양제와 조합 투여하는 것을 포함하는 전술한 방법에 관한 것이다.

일 구체예에서, 본 발명은 상기 티로신 키나제 저해제, 비만세포 저해제 또는 c-Kit 저해제, 특히 마시티닙 또는 약학적으로 허용가능한 그의 염과 적어도 1종의 항종양제를 시간의 관점에서 별도로, 동시에 또는 순차적으로 투여하는 것을 포함하는 전술한 방법에 관한 것이다.

일 구체예에서, 본 발명은 상기 티로신 키나제 저해제, 비만세포 저해제 또는 c-Kit 저해제를 암 치료에 사용되는 시판 의약들로부터 선택된 적어도 1종의 항종양제와 조합하여 투여하는, 전술한 바와 같은 췌장암의 치료방법에 관한 것이다.

일 구체예에서, 본 발명은 상기 환자가 절제불가능한 선암종 췌장암 또는 전이성 선암종 췌장암을 앓는 환자인 것인 전술한 방법에 관한 것이다.

일 구체예에서, 본 발명은 상기 췌장암 환자가 정의된 유전자 발현 예측변수 인자 또는 통증 강도 예측변수 인자 중 어느 하나에 의해 정의되는 바와 같이 상기 치료를 필요로 하는 것이고, 상기 적어도 1종의 항종양제는: 겜시타빈 (Gemzar

; Lilly), 엘로티닙 (Tarceva

; Roche), 파클리탁셀 (Taxol

; Abraxane

; Bristol-Myers Squibb), 폴피리녹스, 5-플루오로우라실 (5-FU), capecitabine, cisplatin, 옥살리플라틴, 이리노테칸, 류코보린, 및 이들 항종양제들의 조합으로부터 선택된다.

일 구체예에서, 상기 적어도 1종의 항종양제는 겜시타빈이다.

바람직한 일 구체예에서, 본 발명은 겜시타빈 및 마시티닙 또는 약학적으로 허용되는 그의 염 또는 수화물로 이루어진 생성물이 사용되는 것인, 전술한 방법에 관한 것이다.

바람직한 일 구체예에서, 본 발명은 출발 투여량을 6.0 ± 1.5 mg/kg/일로 하되 최대 허용가능한 투여량을 9.0 mg/kg/일로 하여 마시티닙을 투여하고 겜시타빈은 1주일 투여량을 1000 ± 250 mg/m²의 환자 체표면적으로 하여 처음 7주일 동안 연속 투여한 다음 1주일간 투여를 중단하고 이어서 28일마다, 3주일 동안 1주일에 1000 ±250 mg/m²의 투여량으로 투여하는 것인, 전술한 방법에 관한 것이다.

또 다른 구체예에서, 본 발명은 임의로 적어도 1종의 항종양제와 조합 사용되는, 전술한 암의 치료방법에 있어서 티로신 키나제 저해제, 비만세포 저해제 또는 c-Kit 저해제의 용도에 관한 것이다.

또 다른 구체예에서, 본 발명은 상기 정의된 암의 치료를 위한, 임의로 적어도 1종의 항종양제와 조합된 티로신 키나제 저해제, 비만세포 저해제 또는 c-Kit 저해제를 포함하는 의약 조성물 또는 키트에 관한 것이다.

또 다른 구체예에서, 본 발명은 상기 정의된 암의 치료용 의약 조성물 또는 키트의 제조에 사용되기 위한, 임의로 적어도 1종의 항종양제와 조합된 티로신 키나제 저해제, 비만세포 저해제 또는 c-Kit 저해제의 용도에 관한 것이다.

또 다른 측면에서, 본 발명은 암, 특히 췌장암의 치료적 관리 플랜에 관한 것으로서, 상기 관리 플랜은 유전자 발현의 정의된 예측변수 인자에 기초하여 치료가능한 환자를 동정하는 것을 포함한다.

일 구체예에서, 전술한 유전자 발현 치료 관리 플랜은 췌장암 환자에게 적용되는데; 여기서 만일 한자가 적어도 하나의 유전자 발현 예측변수 인자를 나타내고, 따라서 정의된 '유전자/전사 지문' 부분모집단에 속하는 것으로 분류되면, 상기 환자는 임의로 적어도 1종의 뉴클레오사이드 유사체, 특히 시티딘 유사체, 특히 겜시타빈과 조합된, 적어도 1종의 티로신 키나제 저해제, 비만세포 저해제 또는 c-Kit 저해제, 특히 마시티닙으로 치료된다. 만일 환자가 적어도 하나의 유전자 발현 예측변수 인자를 나타내지 않고, 따라서 정의된 "비유전자/전사체 지문' 부분모집단에 속하는 것으로 분류되면, 상기 환자는 적어도 1종의 뉴클레오사이드 유사체, 특히 시티딘 유사체, 특히 겜시타빈으로 치료된다.

또 다른 구체예에서, 전술한 유전자 발현 치료 관리 플랜은 췌장암이 아닌 다른 암에 걸린 환자에게 적용되는데; 여기서 만일 환자가 적어도 하나의 유전자 발현 예측변수 인자를 나타내면, 상기 환자는 임의로 적어도 1종의 항종양제와 임의 조합된 적어도 1종의 티로신 키나제 저해제, 비만세포 저해제 또는 c-Kit 저해제, 특히 마시티닙으로 치료된다. 만일 환자가 적어도 하나의 유전자 발현 예측변수 인자를 나타내지 않으면, 상기 환자는 적어도 1종의 항종양제로 치료된다.

또 다른 측면에서, 본 발명은 정의된 통증 강도의 예측변수 인자에 기초하여, 인간 환자에 있어서 암, 특히 췌장암을 치료하기 위한 치료 관리 플랜에 관한 것으로, 상기 관리 플랜은:

a) 상기 환자가 통증과 연관된 암에 걸렸는지 또는 통증, 좋기로는 100 mm 스케일에서 5 mm를 초과하는 시각상사척도(VAS) 점수를 나타내는 것으로 보고된 것으로 정의된 질병 관련 통증의 치료를 위해 적어도 1종의 아편유사 진통제의 투여를 필요로 하는지를 결정하는 단계; 및 임의로

b) 상기 질병 관련 통증이 100 mm 스케일에서 상기 암에 대하여 사전 정의된 값보다 높은지, 특히 췌장암에서 100 mm 스케일에서 시각상사척도 (VAS) 통증 강도 점수가 20 mm를 초과하는지를 결정하는 단계

를 포함하는 것이다.

일 구체예에서 상기 질병 관련 통증에 대해 사전 정의된 값은 100 mm 스케일에서 20 mm이다.

일 구체예에서, 전술한 통증 강도 치료 관리 플랜은 췌장암 환자에게 적용되는데; 여기서, 만일 단계 (a)가 부정적이면, 환자를 적어도 1종의 뉴클레오사이드 유사체, 특히 시티딘 유사체, 특히 겜시타빈으로 치료한다. 만일 단계 (a)가 긍정적이고 단계 (b)가 부정적이면, 적어도 1종의 약물 표적 표피성장인자 수용체 (EGFR), 특히 엘로티닙을 적어도 1종의 뉴클레오사이드 유사체, 특히 시티딘 유사체, 특히 겜시타빈과 조합하거나; 또는 적어도 1종의 유사분열(mitotic) 저해제, 특히 파클리탁셀을 적어도 1종의 뉴클레오사이드 유사체, 특히 시티딘 유사체, 특히 겜시타빈과 조합하거나; 플루오로우라실, 류코보린, 이리노테칸, 또는 옥살리플라틴, 특히 폴피리녹스를 포함하는 약물들의 적어도 1종의 조합으로 환자를 치료한다. 만일 단계 (a)의 결과가 긍정적이고 단계 (b)의 결과도 긍정적이면, 적어도 1종의 티로신 키나제 저해제, 비만세포 저해제 또는 c-Kit 저해제, 특히 마시티닙을, 임의로 적어도 1종의 뉴클레오사이드 유사체, 특히 시티딘 유사체, 특히 겜시타빈과 조합하여 환자를 치료한다.

또 다른 구체예에서, 전술한 통증 강도 치료 관리 플랜을 췌장암이 아닌 다른 암에 걸린 환자에게 적용하는데, 여기서, 만일 단계 (a)가 부정적이면, 환자를 적어도 1종의 항종양제로 치료한다. 만일 단계 (a)가 긍정적이고 단계 (b)가 부정적이면, 환자를 적어도 1종의 항종양제로 치료한다. 만일 단계 (a)의 결과가 긍정적이고 단계 (b)의 결과도 긍정적이면, 적어도 1종의 티로신 키나제 저해제, 비만세포 저해제 또는 c-Kit 저해제, 특히 마시티닙을 임의로 적어도 1종의 항종양제와 조합하여 환자를 치료한다.

또 다른 측면에서, 본 발명은 인간 환자에 있어서, 암, 특히 췌장암의 치료를 위한 전체(global) 치료 관리 플랜에 관한 것으로서, 여기서 상기 관리 플랜은 유전자 발현 치료 관리 플랜 및 통증 강도 치료 관리 플랜을 순차로 적용한 결과에 기초해서 치료가능한 환자를 동정하는 것을 포함한다. 따라서, 전술한 통증 강도 치료 관리 플랜에서, 단계 (a)에 앞서서, 전술한 바와 같은 적어도 하나의 유전자 발현 예측변수 인자를 나타내는 환자들을 동정하는 것으로 이루어진 단계 (a')를 먼저 실시할 수 있다.

일 구체예에서, 전술한 전체 치료 관리 플랜은 췌장암에 적용되며, 여기서; 단계 (a')의 결과가 긍정적이면, 적어도 1종의 티로신 키나제 저해제, 비만세포 저해제 또는 c-Kit 저해제, 특히 마시티닙을 임의로 적어도 1종의 뉴클레오타이드 유사체, 특히 시티딘 유사체, 특히 겜시타빈과 조합하여 환자를 치료하고; 만일 단계 (a')의 결과가 부정적이면, 췌장암에 대한 통증 강도 치료 관리 플랜의 단계 (a)를 적용한다. 특히, 상기 관리 플랜은:

a) 상기 환자가 통증과 연관된 췌장암에 걸렸는지 또는 통증, 좋기로는 100 mm 스케일에서 5 mm를 초과하는 시각상사척도(VAS) 점수를 나타내는 것으로 보고된 것으로 정의된 질병 관련 통증의 치료를 위해 적어도 1종의 아편유사 진통제의 투여를 필요로 하는지를 결정하는 단계; 및 임의로

b) 상기 질병 관련 통증이 100 mm 스케일에서 20 mm를 초과하는 시각상사척도 (VAS) 통증 강도 점수를 나타내는 지를 결정하는 단계

를 포함하는 것이다.

- 단계 (a)의 결과가 부정적이면, 환자를 적어도 1종의 뉴클레오사이드 유사체, 특히 시티딘 유사체, 특히 겜시타빈으로 치료한다.

- 단계 (a)의 결과가 긍정적이고, 단계 (b)의 결과는 부정적이면, 적어도 1종의 약물 표적 표피성장인자 수용체 (EGFR), 특히 엘로티닙을 적어도 1종의 뉴클레오사이드 유사체, 특히 시티딘 유사체, 특히 겜시타빈과 조합한 것; 또는 적어도 1종의 유사분열 저해제, 특히 파클리탁셀을 적어도 1종의 뉴클레오사이드 유사체, 특히 시티딘 유사체, 특히 겜시타빈과 조합한 것; 또는 플루오로우라실, 류코보린, 이리노테칸, 또는 옥살리플라틴, 특히 폴피리녹스를 포함하는 약물들의 적어도 1 가지 조합으로 환자를 치료한다.

- 단계 (a)의 결과가 긍적적이고, 단계 (b)의 결과도 긍정적이면, 적어도 1종의 티로신 키나제 저해제, 비만세포 저해제 또는 c-Kit 저해제, 특히 마시티닙을, 임의로 적어도 1종의 뉴클레오사이드 유사체, 특히 시티딘 유사체, 특히 겜시타빈과 조합하여 환자를 치료한다.

또 다른 구체예에서, 전술한 전체 치료 관리 플랜을 췌장암이 아닌 다른 암에 걸린 환자에게 적용하는데, 여기서는, 만일 단계 (a')이 긍적적이면, 적어도 1종의 티로신 키나제 저해제, 비만세포 저해제 또는 c-Kit 저해제, 특히 마시티닙을, 임의로 적어도 1종의 항종양제와 조합하여 환자를 치료한다. 만일 단계 (a')가 부정적이면, 암에 대한 통증 강도 치료 관리 플랜의 단계 (a)를 적용한다. 특히, 상기 관리 플랜은:

b) 상기 질병 관련 통증이 100 mm 스케일에서 상기 암에 대하여 사전 정의된 것보다 높은 된시각상사척도 (VAS) 통증 강도 점수를 나타내는지를 결정하는 단계

를 포함하는 것이다.

- 단계 (a)의 결과가 부정적이면, 환자를 적어도 1종의 항종양제로 치료한다.

- 단계 (a)의 결과가 긍정적이고 단계 (b)의 결과가 부정적이면, 환자를 적어도 1종의 항종양제로 치료한다.

- 단계 (a)의 결과가 긍적적이고 단계 (b)의 결과도 긍정적이면, 적어도 1종의 티로신 키나제 저해제, 비만세포 저해제 또는 c-Kit 저해제, 특히 마시티닙을 임의로 적어도 1종의 항종양제와 조합한 것으로 환자를 치료한다.

도 3은 췌장암 환자에 있어서 개별적인 통증 강도의 예측변수 인자들과 유전자 발현과 연관된 치료 관리 플랜 및 두 가지 예측변수 인자들 모두를 고려한 전체 치료 관리 플랜을 나타낸 도면이다. readerdc[xxx]_install.exe

첨부된 도면에서:
도 1은: 다변량분석에서 사망에 대한 위험 비율 대 VAS 점수를 나타내고;
도 2는: VAS 스케일 및 사용자 지침을 예시한 도면이다.
도 3은: 통증 강도 및 현유전자 발현의 예측변수 인자에 기초한 치료 관리 플랜을 도시한 것이고;
도 4는: '통증' 부분모집단에 있어서의 생존 확률 평가도 (다변량분석);
도 5는: '무통, 무모르핀' 부분모집단에 있어서의 생존 확률 평가도 (다변량분석);
도 6은: '중앙 미만의 통증' 부분모집단에 있어서의 생존 확률에 대한 카플란-마이어 평가도이다(다변량분석).
도 7은: '유전자 지문' 부분모집단에 있어서의 생존 확률(다변량분석)을 나타내고,
도 8은: '비유전자 지문' 부분모집단에 있어서의 생존 확률(다변량분석)을 나타낸다.

발명의 상세한 설명

티로신 키나제는 티로신의 ATP의 말단 포스페이트를 단백질의 티로신 잔기로 전달함으로써 시그널 트랜스덕션 경로를 활성화 또는 불활성화시키는, 수용체 유형 또는 비수용체 유형의 단백질이다. 이 단백질들은 그것이 파괴될 경우, 비정상적인 세포 증식 및 세포 이동 뿐만 아니라 염증과 같은 질병에 이르게 하는, 많은 세포 메카니즘에 관여하는 것으로 알려져 있다. 티로신 키나제 저해제는 티로신 키나제를 저해함으로 해서, 세포 내에서 시그널 프로세스를 간섭하는 약물이다. 이러한 프로세스를 차단하면 세포 성장과 분화를 중지시킬 수 있다.

일 구체예에서, 본 발명의 티로신 키나제 저해제는 다음 화학식 [A]를 갖는 것이거나 약학적으로 허용가능한 그의 염 또는 용매화물(solvate)이다:

식 중, R₁ 및 R₂는 수소, 할로겐, 1 내지 10개의 탄소 원자를 함유하는 선형 또는 분지형 알킬, 시클로알킬기, 트리플루오로메틸, 알콕시, 시아노, 디알킬아미노, 및 가용화기(solubilizing group)로부터 독립적으로 선택되고,

m은 0-5이고 n은 0-4이며;

R₃ 기는 다음 중 하나이다:

(i) 페닐과 같은 아릴기 또는, 할로겐, 1 내지 10개의 탄소 원자를 갖는 알킬기, 트리플루오로메틸, 시아노 및 알콕시와 같은 1 이상의 치환기들의 조합을 고리의 임의 위치에 갖는 그의 치환된 변형체;

(ii) 할로겐, 1 내지 10개의 탄소 원자를 함유하는 알킬기, 트리플루오로메틸 및 알콕시와 같은 1 이상의 치환기의 조합을 부가적으로 가질 수 있는, 2, 3 도는 4-피리딜기와 같은 헤테로아릴기;

(iii) 할로겐, 1 내지 10개의 탄소 원자를 함유하는 알킬기, 트리플루오로메틸 및 알콕시와 같은 1 이상의 치환기의 조합을 부가적으로 가질 수 있는, 예컨대 2-티에닐, 3-티에닐, 2-티아졸릴, 4-티아졸릴, 5-티아졸릴과 같은 5원 고리 방향족 헤테로시클릭기.

화학식 [A]의 티로신 키나제 저해제는 좋기로는 c-Kit 저해제로서 사용될 수 있다.

달리 명시되지 않는 한, 본 명세서에서 하기 용어들은 다음과 같이 정의되어 사용된다:

본 명세서에서, "아릴기"라는 용어는 탄소 및 수소 원자들을 포함하는 모노시클릭 또는 폴리시클릭-방향족 라디칼을 의미한다. 적절한 아릴기의 비제한적인 예로는, 페닐, 톨릴, 안트라세닐, 플루오레닐, 인데닐, 아줄레닐 및 나프틸, 그리고, 벤조-융합된 카르소시클릭 모이어티 에컨대 5,6,7,8-테트라히드로나프틸을 들 수 있다. 아릴기는 비치환되거나 또는 1 이상의 치환기에 의해 치환될 수 있다. 일 구체예에서, 아릴기는 6개의 탄소 원자를 포함하는 모노시클릭 고리로서, 본 명세서에서 "(C₆)아릴"로서 표시된다.

본 명세서에서 "알킬기"라는 용어는 1 내지 10개의 탄소 원자를 갖는 포화된 직쇄 또는 분지형 비시클릭 탄화수소를 의미한다. 대표적인 포화 직쇄 알킬에는 메틸, 에틸, n-프로필, n-부틸, n-펜틸, n-헥실, n-헵틸, n-옥틸, n-노닐 및 n-데실이 포함되며; 포화된 분지형 알킬로는 이소프로필, 2차-부틸, 이소부틸, 3차-부틸, 이소펜틸, 2-메틸부틸, 3-메틸부틸, 2-메틸펜틸, 3-메틸펜틸, 4-메틸펜틸, 2-메틸헥실, 3-메틸헥실, 4-메틸헥실, 5-메틸헥실, 2,3-디메틸부틸, 2,3-디메틸펜틸, 2,4-디메틸펜틸, 2,3-디메틸헥실, 2,4-디메틸헥실, 2,5-디메틸헥실, 2,2-디메틸펜틸, 2,2-디메틸헥실, 3,3-디메틸펜틸, 3,3-디메틸헥실, 4,4-디메틸헥실, 2-에틸펜틸, 3-에틸펜틸, 2-에틸헥실, 3-에틸헥실, 4-에틸헥실, 2-메틸-2-에틸펜틸, 2-메틸-3-에틸펜틸, 2-메틸-4-에틸펜틸, 2-메틸-2-에틸헥실, 2-메틸-3-에틸헥실, 2-메틸-4-에틸헥실, 2,2-디에틸펜틸, 3,3-디에틸헥실, 2,2-디에틸헥실, 3,3-디에틸헥실 등을 들 수 있다. 본 발명의 화합물에 포함되는 알킬기는 1 이상의 치환기에 의해 임의 치환될 수 있다.

본 명세서에서 "알콕시"라는 용어는 산소 원자에 의해 다른 모이어티에 결합된 알킬기를 의미한다. 알콕시기의 예로는 메톡시, 이소프로폭시, 에톡시, 3차-부톡시 등을 들 수 있다. 알콕시기는 1 이상의 치환기에 의해 임의 치환될 수 있다.

본 명세서에서, "헤테로아릴" 등의 용어는 탄소 원자 고리 멤버 또는 1 이상의 헤테로원자 고리 멤버(예컨대 산소, 황 또는 질소)를 포함하는 모노시클릭 또는 폴리시클릭 헤테로방향족 고리를 의미한다. 일반적으로, 헤테로아릴기는 1 내지 5개의 헤테로원자 고리 멤버와 1 내지 14개의 탄소 원자 고리 멤버를 갖는다. 대표적인 헤테로아릴기의 예로는 피리딜, 1-옥소-피리딜, 퓨라닐, 벤조[1,3]디옥솔릴, 벤조[1,4]디옥시틸, 티에닐, 피롤릴, 옥사졸릴, 이미다졸릴, 티아졸릴, 이속사졸릴, 퀴놀리닐, 피라졸릴, 이소티아졸릴, 피리다지닐, 피리미디닐, 피라지닐, 트리아지닐, 트리아졸릴, 티아디아졸릴, 이소퀴놀리닐, 인다졸릴, 벤족사졸릴, 벤조퓨릴, 인돌리지닐, 이미다조피리딜, 테트라졸릴, 벤즈이미다졸릴, 벤조티아졸릴, 벤조티아디아졸릴, 벤족사디아졸릴, 인돌릴, 테트라히드로인돌릴, 아자인돌릴, 이미다조피리딜, 퀴나졸리닐, 퓨리닐, 피롤로[2,3]피리미디닐, 피라졸로[3,4]피리미디닐, 이미다조[1,2-a]피리딜, 및 벤조(b)티에닐을 들 수 있다. 헤테로원자는 통상의 기술자에게 잘 알려진 보호기에 의해 치환될 수 있는데, 예컨대 질소 상 수소는 3차-부톡시카르보닐기로 치환될 수 있다. 헤테로아릴기는 1 이상의 치환기들에 의해 임의 치환될 수 있다. 또한, 질소 또는 황 헤테로원자 고리 멤버는 산화될 수도 있다. 일 구체예에서, 헤테로방향족 고리는 5-8원 모노시클릭 헤테로아릴 고리로부터 선택된다. 헤테로방향족 또는 헤테로아릴 고리의 다른 기에 대한 결합점은 그 헤테로방향족 고리나 헤테로아릴 고리의 탄소 원자 또는 헤테로원자일 수 있다.

본 명세서에서 "헤테로사이클"이라는 용어는 집합적으로 헤테로시클로알킬기와 헤테로아릴기를 가리킨다.

본 명세서에서, "헤테로시클로알킬"이라는 용어는 O, N 또는 S로부터 선택된 적어도 하나의 헤테로원자와 2-11개의 탄소 원자를 가지며, 포화 또는 불포화되지만 방향족은 아닌 모노시클릭 또는 폴리시클릭기를 의미한다. 헤테로시클로알킬기의 예로는: 피페리디닐, 피페라지닐, 2-옥소피페라지닐, 2-옥소피페리디닐, 2-옥소피롤리디닐, 4-피페리도닐, 피롤리디닐, 히단토이닐, 발레로락타밀, 옥시라닐, 옥세타닐, 테트라히드로피라닐, 테트라히드로티오피라닐, 테트라히드로피리디닐, 테트라히드로피리미디닐, 테트라히드로티오피라닐 술폰, 테트라히드로티오피라닐 술폭사이드, 모르폴리닐, 티오모르폴리닐, 티오모르폴리닐 술폭사이드, 티로모르폴리닐 술폰, 1,3-디옥솔란, 테트라히드로퓨라닐, 디히드로퓨라닐-2-온, 테트라히드로티에닐 및 테트라히드로-1,1-디옥소티에닐을 들 수 있으나 이에 한정되지 않는다. 일반적으로, 모노시클릭 헤테로시클로알킬기는 3 내지 7개의 고리원을 갖는다. 바람직한 3 내지 7원 모노시클릭 헤테로시클로알킬기는 5 또는 5개의 고리 원자를 갖는 것들이다. 헤테로원자는 통상의 기술자에게 알려진 보호기에 의해 치환될 수 있는데, 예를 들어, 질소 상의 수소는 3차-부톡시카르보닐기에 의해 치환될 수 있다. 또한, 헤테로시클로알킬기는 1 이상의 치환기들에 의해 임의 치환될 수 있다. 또한, 다른 기에 대한 헤테로시클릭 고리의 결합점은 헤테로시클릭 고리의 탄소 원자 또는 헤테로원자일 수 있다. 이러한 치환된 헤테로시클릭기의 안정한 이성질체만이 이 정의에서 논의되는 것으로 한다.

본 명세서에서 "치환기" 또는 "치환된"이라는 용어는 어떤 화합물 또는 기의 수소 래디칼이 보호되지 않은 형태로 또는 보호기를 이용하여 보호된 형태에서 반응 조건에서 실제로 안정한 소망되는 기에 의해 대체된 것을 의미한다. 바람직한 치환기의 예는 본 명세서에 기재된 예시적인 화합물 및 구체예에서 찾아볼 수 있으며, 할로겐(클로로, 요오도, 브로모 또는 플루오로); 알킬; 알케닐; 알키닐; 히드록시; 알콕시; 니트로; 티올; 티오에테르; 이민; 시아노; 아미도; 포스포네이토; 포스핀; 카르복실; 티오카르보닐; 술포닐; 술폰아미드; 케톤; 알데히드; 에스테르; 산소(-O); 할로알킬(예컨대, 트리플루오로메틸); 모노시클릭 또는 융합되거나 융합되지 않은 폴리시클릭 (예컨대, 시클로프로필, 시클로부틸, 시클로펜틸 또는 시클로헥실)일 수 있는 시클로알킬, 또는 모노시클릭 또는 융합되거나 융합되지 않은 폴리시클릭 (예컨대, 피롤리디닐, 피페리디닐, 피페라지닐, 모르폴리닐, 또는 티아지닐)일 수 있는 헤테로시클로알킬, 모노시클릭 또는 유합되거나 융합되지 않은 폴리시클릭 아릴 또는 헤테로아릴 (예컨대, 페닐, 나프틸, 피롤릴, 인돌릴, 퓨라닐, 티오페닐, 이미다졸릴, 옥사졸릴, 이속옥사졸릴, 티아졸릴, 트리아졸릴, 테트라졸릴, 피라졸릴, 피리딜, 퀴놀리닐, 이소퀴놀리닐, 아크리디닐, 피라지닐, 피리다지닐, 피리미디닐, 벤즈이미다졸릴, 벤조티오페닐, 또는 벤조퓨라닐); 아미노 (1차, 2차 또는 3차); CO₂CH₃; CONH₂; OCH₂CONH₂; NH₂; SO₂NH₂; OCHF₂; CF₃; OCF₃ 일 수 있는데, 이러한 모이어티들은 또한 융합된-고리 구조 또는 브릿지된, 예컨대 -OCH₂O-에 의해 임의 치환될 수도 있다. 이러한 치환기들은 이러한 기들로부터 선택된 치환기에 의해 임의로 더 치환될 수도 있다. 특정 구체예에서, "치환기" 또는 서술어 "치환된"이라는 표현은 다음으로 이루어진 군으로부터 선택된 치환기를 가리킨다: 알킬, 알케닐, 알키닐, 시클로알킬, 시클로알케닐, 헤테로시클로알킬, 아릴, 헤테로아릴, 아르알킬, 헤테르아르알킬, 할로알킬, -C(O)NR₁₁R₁₂, -NR₁₃C(O)R₁₄, 할로, -OR₁₃, 시아노, 니트로, 알로알콕시, -C(O)R₁₃, -NR₁₁R₁₂, -SR₁₃, -C(O)OR₁₃, -OC(O)R₁₃, -NR₁₃C(O)NR₁₁R₁₂, -OC(O)NR₁₁R₁₂, -NR₁₃C(O)OR₁₄, -S(O)rR₁₃, -NR₁₃S(O)rR₁₄, -OS(O)rR₁₄, S(O)rNR₁₁R₁₂, -O, -S, 및 -N-R₁₃, 여기서 r은 1 또는 2; R₁₁ 및 R₁₂는 각각의 경우, 독립적으로, H, 임의 치환된 알킬, 임의 치환된 알케닐, 임의 치환된 알키닐, 임의 치환된 시클로알킬, 임의 치환된 시클로알케닐, 임의 치환된 헤테로시클로알킬, 임의 치환된 아릴, 임의 치환된 헤테로아릴, 임의 치환된 아르알킬, 또는 임의 치환된 헤테르아르알킬을 나타내거나; 또는 R₁₁ 및 R₁₂는 이들이 결합된 질소와 함께 임의 치환된 헤테로시클로알킬 또는 임의 치환된 헤테로아릴을 나타내며; 및 R₁₃ 및 R₁₄는 각각의 경우, 독립적으로, H, 임의 치환된 알킬, 임의 치환된 알케닐, 임의 치환된 알키닐, 임의 치환된 시클로알킬, 임의 치환된 시클로알케닐, 임의 치환된 헤테로시클로알킬, 임의 치환된 아릴, 임의 치환된 헤테로아릴, 임의 치환된 아르알킬 또는 임의 치환된 헤테르아르알킬을 나타낸다.

특정 구체예에서, "치환기" 또는 서술어 "치환된"이라는 표현은 가용화기를 가리킨다.

"가용화기(solubilizing group)"라는 용어는 실제로 이온화되어 화합물을 예컨대 물이나 물-함유 용매와 같은 소망되는 용매에서 용해되게 만드는 임의의 기를 의미한다. 또한, 가용화기는 화합물 또는 복합체의 친지성을 증가시키는 것일 수도 있다. 일반적으로 가용화기는 N, O S와 같은 1 이상의 헤테로원자들로 치환된 알킬기로부터 선택되는데, 이들은 각각 알콕시, 아미노, 알킬아미노, 디알킬아미노, 카르복실, 시아노에 의해 독립적으로 치환되거나 또는 시클로헤테로알킬 또는 헤테로아릴, 또는 포스페이트 또는 술페이트 또는 카르복실산에 의해 치환된다. 예를 들어, 본 명세서에서 "가용화기"라는 용어는 다음 중 어느 하나를 가리킨다:

- 적어도 하나의 질소 또는 산소 헤테로원자를 포함하는 알킬, 시클로알킬, 아릴, 헤테로아릴기 또는 적어도 하나의 아미노기 또는 옥소기에 의해 치환된 기;

- 알킬, 알콕시카르보닐, 할로겐, 할로알킬, 히드록시알킬, 아미노, 모노알킬아미노, 디알킬아미노, 카르바모일, 모노알킬카르바모일 및 디알킬카르바모일로 이루어진 군으로부터 선택된 기에 의해 치환될 수 있는 포화된 시클릭 아미노기일 수 있는 아미노기;

- 아래의 a) 내지 i)의 구조 중 어느 하나를 갖되, 파기 구조식에서 파선과 화살선은 화학식 [A]의 중심 구조에 대한 결합점에 대응하는 것임;

"시클로알킬"이라는 용어는 3 내지 10개의 탄소 원자를 갖는 포화된 시클릭 알킬 래디칼을 의미한다. 대표적인 시클로알킬에는 시클로프로필, 1-메틸시클로프로필, 시클로부틸, 시클로펜틸, 시클로헥실, 시클로헵틸, 시클로옥틸, 시클로노닐, 및 시클로데실이 포함된다. 시클로알킬기는 1 이상의 치환기에 의해 임의 치환될 수 있다.

"할로겐"이라는 용어는 -F, -Cl, -Br 또는 -I를 의미한다.

특정 구체예에서 본 발명의 티로신 키나제 저해제는 다음 화학식 [B]를 갖는다,

식 중:

R₁은 수소, 할로겐, 1 내지 10개의 탄소 원자를 함유하는 선형 또는 분지형 알킬, 시클로알킬기, 트리플루오로메틸, 알콕시, 아미노, 알킬아미노, 디알킬아미노, 가용화기로부터 독립적으로 선택되고 m은 0-5이다.

일 구체예에서, 티로신 키나제 저해제, 비만세포 저해제 또는 c-Kit 저해제는 마시티닙 또는 약학적으로 허용가능한 그의 염, 더욱 좋기로는 마시티닙 메실레이트인 것이 좋다.

마시티닙은 강력한 항비만세포 작용을 갖는 c-Kit / PDGFR 저해제이다.

AB 사이언스사의 PCT 출원 WO 2004/014903에 설명된 2-(3-아미노아릴)아미노-4-아릴-티아졸은 새로운 강력하고도 선택적인 c-Kit, 혈소판 유도된 성장인자 수용체(PDGFR) 저해제이다.

마시티닙은 치료 투여량에서 공지 독성과 관련된 키나제를 저해함이 없이, c-Kit, PDGFR, Lyn, Fyn, 및 DDR1과 같은 특정 티로신 키나제를 선택적으로 저해하는 소분자 약물이다(즉 ABL, KDR 및 Src를 비롯하여, 가능한 티로신 키나제 저해재 심장 독성에 관여하는 티로신 키나제 또는 티로신 키나제 수용체들) [Dubreuil 등, 2009, PLoS ONE 2009.4(9):e7258; Davis 등, Nat Biotechnol 2011, 29(11): 1046-51]. 마시티닙의 화학명은 4-(4-메틸피페라진-1-일메틸)-N-[4-메틸-3-(4-피리딘-3일티아졸-2-일아미노)페닐]벤즈아미드 - CAS 번호 790299-79-5이며, 그 구조는 하기와 같다. 마시티닙은 US 7,423,055 및 EP1525200B1에 최초로 설명된었다. 마시티닙 메실레이트의 자세한 합성방법은 WO2008/098949에 설명되어 있다.

마시티닙의 주요 키나제 표적은 c-Kit인데, 야생형 및 막의 한면이 돌연변이된(juxtamembrane-mutated) c-Kit 수용체에 강한 저해 효과를 발휘하여, 세포 사이클을 중단시키고 c-Kit 시그널링에 의존하여 세포주의 세포자멸사를 일으키는 것으로 나타났다 [Dubreuil 등, 2009, PLoS ONE, 4(9):e7258]. 시험관내에서, 마시티닙은 c-Kit에 대해 높은 활성과 선택성을 나타내는 것으로 입증되었는데, 재조합 인간 야생형 c-Kit에 대해 200±40 nM의 IC50을 나타내고 줄기세포 인자-유도된 증식을 차단하며 인간 또는 마우스 야생형 c-Kit을 발현하는 Ba/F3 세포에서 c-Kit 티로신 인산화에 대해 150 ± 80 nM의 IC50을 나타낸다. 마시티닙은 그의 항증식 특성에 더해서, IgE 유도된 탈과립화를 유도하는 트랜스덕션 경로의 핵심 성분들인 Lyn 및 Fyn을 표적화함으로써 비만세포의 활성화를 조절할 수도 있다 [(Gilfillan 등, 2006, Nat Rev Immunol, 6:218-230); (Gilfillan 등, 2009, Immunological Reviews, 228:149-169)]. 이것은 인간 제대혈 비만세포의 FcεRI-매개된 탈과립화의 저해에서 관찰될 수 있다 [Dubreuil 등, 2009, PLoS ONE;4(9):e7258]. 마시티닙은 또한 PDGFR α 및 베타 수용체의 저해제이기도 하다. 재조합 분석 결과 마시티닙은 PDGFR-α 및 베타의 시험관내 단백질 키나제 활성을 IC50 값 540 ± 60 nM 및 800 ± 120 nM로 저해하였다. PDGFR-α를 발현하는 Ba/F3 세포에서, 마시티닙은 PDGF-BB-자극된 증식 및 PDGFR-α 티로신 인산화를 IC50 값 300 ± 5 nM로 저해하였다. 또한, 마시티닙은 디스코이딘 영역 수용체 패밀리 멤버 1(discoidin domain receptor family member 1:DDR1) 키나제와 강하게 상호작용함으로 해서, DDR1 자가인산화의 강한 억제를 유도한다. 비록 DDR1의 생리학적 기능이 완전히 이해되지는 않으나, DDR1 시그널링은 세포외 매트릭스와 세포 상호반응함으로서 암 세포의 기본적인 2 가지 특성들인 부착 및 세포 이동을 제어하는 것으로 여겨진다. 이러한 능력의 탈조절은 여러 종류의 인간 암에 있어서 종양의 진행 및 불량한 예후와 연관이 있다. 마시티닙은 DDR1 수용체에 강력하게 결합하여 그의 활성을 저해하는 것으로 나타났다 [Davis 등, Nat Biotechnol 2011, 29(11): 1046-51]. 마시티닙은 따라서 종양 세포의 귀소(homing) 및 집락화를 둔화시킬 수 있다.

본 발명은 인간 환자에 있어서 암의 치료방법에 관한 것으로서, 상기 방법은 치료를 필요로 하는 인간 환자에게 티로신 키나제 저해제, 비만세포 저해제 또는 c-Kit 저해제, 특히 마시티닙 또는 약학적으로 허용가능한 그의 염을, 임의로, 적어도 1종의 항종양제와 조합하여 투여하는 것을 포함한다.

본 발명과 관련하여, "치료" (및 그의 다양한 문법적 변형 표현)라는 용어는 질병 상태, 질병 진행, 질병의 원인물질(예컨대 세균 또는 바이러스) 또는 기타 비정상적인 병태의 유해한 효과를 예방, 치료, 역전, 경감, 완화, 최소화, 억제 또는 중단시키는 것을 가리킨다. 예를 들어, 치료는 어떤 질병의 한 증상(즉, 반드시 모든 증상일 필요는 없음)을 완화시키거나 또는 질병의 진행을 약화시키는 것과 관련된 것일 수 있다.

본 발명자들은 놀랍게도 마시티닙 플러스 겜시타빈의 조합이 독립 예측변수 인자로서 작용하는 통증 강도를 갖는 췌장암 환자들의 고도로 독특한(highly distinct) 부분모집단에 대해 치료적 잇점을 제공하는 것을 발견하였다.

무작위화된 위약-조절된 3상 연구(AB07012)를 전술한 시험관내 및 예비 생체내 데이터에 기초하여 수행하여

was conducted based on the aforementioned in vitro 및 preliminary in vivo data to determine the efficacy 및 safety of a 마시티닙 in combination with 겜시타빈 compared with 겜시타빈 alone as first-line therapy in 환자s with 진행/전이 췌장암을 앓는 환자들에 있어서 일차 치료법으로서 겜시타빈과 조합된 마시티닙의 유효성 및 안전성을 겜시타빈 단독의 경우와 비교하였다 (실시예 1). 마시티닙으로 처리된 환자의 생존율이 향상되었다면 그러한 작용에 책임이 있는 주요 메카니즘은 겜시타빈에 대한 췌장암 세포의 마시티닙-유도된 감작화일 것으로 강하게 예측되었다. 따라서,

It was strongly predicted that the principal mechanism of action responsible for any improvement in 마시티닙 treated 환자 survival would be a 마시티닙-induced sensitization of 췌장암 cells to 겜시타빈. It follows therefore, that the 환자 모집단 to benefit from the 마시티닙 플러스 겜시타빈 combination would closely mirror that for 겜시타빈 treatment, regardless of 부분모집단 variables such as 환자 수행도, 연령, 또는 종양 국소화 등과 같은 부분모집단 변수들과 관계없이, 마시티닙 플러스 겜시타빈 조합으로부터 이익을 받을 환자 모집단은 겜시타빈 처리의 경우를 밀접하게 반영할 것으로 고려되었다 : 즉 국소적으로 진행된(절제불능한 II기 또는 III기) 또는 전이성 (IV기) 췌장 선암종.

AB07012의 연구 결과 (mITT) 모집단을 치료하고자 하는 변경된 의도에서는, 겜시타빈 플러스 위약, 즉 겜시타빈을 단일 제제로서 투여받은 환자와 비교할 때 마시티닙 플러스 겜시타빈 조합으로 처리된 환자에서는 생존 측면에서 별다른 이로운 점이 없었다(실시예 1). 예기치 않게도, 통증 강도에 따라 계층화된 전체 생존에 대한 2차의 탐사적인 분석결과, 통증과 연관된 췌장암 환자 또는 질병 관련 통증의 치료를 위해 아편유사 진통제가 요구되는 환자들의 부분모집단에서, 단일 제제로서 겜시타빈과 비교할 때 마시티닙 플러스 겜시타빈은 생존을 연장시킨 것으로 나타났다. 이러한 데이터는 또한, 전례없이, 겜시타빈을 단일 제제로서 투여받는(현행의 치료 스탠다드) 환자들의 전체 생존율에 있어서 통증 강도가 주요한 예후인자였음도 보여주었다. 구체적으로, 데이터는 단일 제제로서 겜시타빈을 투여받은 환자들(즉 위약 플러스 겜시타빈 치료군)의 경우, 베이스라인에 질병 관련 통증이 있는 환자들과 질병 관련 통증이 없거나 질병 관련 통증 치료를 위한 아편 유사 진통제를 필요로 하지 않는 환자들 사이에는 생존기간이 10.0 개월 차이가 있엇다 (중앙 OS가 각각 5.4 대 15.4 개월이었엄) (실시예 1). 또한, 통증 강도에 따라 전체 생존율의 위험 비율의 발달에 따르자, 위약 플러스 겜시타빈이 투여된 환자에 비해 마시티닙 플러스 겜시타빈을 투여받은 환자들에 있어서 통증 강도가 증가와 더불어 생존 확률이 개선된 것으로 나타났다. 이러한 관계는 위약 플러스 겜시타빈 하의 사망 확률에 대한 마시티닙 플러스 겜시타빈 하의 사망 확률을 VAS 점수에 대하여 나타낸 사망 위험 비율 곡선으로 나타내진다(도 1). 사망 위험 비율은 20 mm의 VAS 점수로부터 VAS 점수가 플래토(또는 수평 점근선:horizontal asymptote)에 이를 때까지 VAS 점수가 증가함에 따라 감소되는 경향이 있엇다. VAS 점수가 55 mm 였을 때, 환자들의 수는 급감하였고 이에 따라 위험 비율은 추가 분석에서 합당하지 않았다. 이러한 결과는 전체 모집단을 3개의 VAS 통증 강도 부분모집단, 즉: VAS [0; 5], VAS ]5; 20], 및 VAS >20으로 나눈 선택방식을 뒷받침해준다 (실시예 1).

이러한 발견은 전례없던 것이며, 암 환자들에 있어서 통증 강도의 예측적인 치료적 유의성이 이전에 알려져 있지 않았던 것이므로 중요한 것이다. 실제로, 췌장암에 있어서 엘로티닙(Tarceva

, EGFR 성장인자의 저해제) 플러스 겜시타빈을 평가하기 위한 이전의 한 연구는 균등한 '통증' 부분모집단에 있어서, 생존율 상의 잇점은 존재하지 않았음을 보여준 바 있다 [Moore MJ, 등, J Clin Oncol. 2007 May 20;25(15):1960-6]. 이것은 마시티닙 플러스 겜시타빈 조합에 대한 발견과 직접 대조되는 것이다. 데이터는 또한 조합요법의 관찰된 치료적 잇점에 책임이 있는 작용 메카니즘이 비교적 느리게 개시되므로, 얻어질 최적 치료 효과를 얻는데 최소한의 노출 시간이 필요함을 가리킨다.

이러한 결과는 연구 AB07012 이전에 습득된 지식이나 또는 일반적인 과학 문헌으로부터는 예측할 수 없었던 것이다. 뿐만 아니라, 이러한 발견은 췌장암에 있어서 마시티닙 플러스 겜시타빈 조합의 주요 작용 메카니즘에 대한 본 발명자들의 초기의 이해, 즉, 겜시타빈에 대한 췌장암 세포들의 마시티닙-유도된 감작화와 매우 상충되는 것이다 [Humbert M, 등 (2010) PLoS ONE 5(3): e9430. doi:10.1371/journal.pone.0009430]. 이러한 데이터는 췌장암 치료의 생체내 임상 세팅에 있어서, 다음과 같은 이유로 췌장암 세포의 감작화가 마시티닙의 주요한 작용 메카니즘이 될 수 없음을 효과적으로 나타내는 것이다: (i) 통증 강도와 관련된 환자들의 질병에 대하여 이질성이 없어야 하고; 및 (ii) 이러한 효과가 비교적 신속하게 개시되고 그에 따라 개선된 무진행 생존에서 발현될 것으로 예측되나, 실제로는 그렇지 않음.

연구 AB07012로부터의 데이터 (실시예 1 참조)는 매우 독특한 췌장암 환자들의 부분모집단이 마시티닙 플러스 겜시타빈 조합에 대해 반응하되, 질병 관련 통증의 정도(강도)에 따라 차이가 있다는 놀라운 발견에 이르게 하였다. 또한 예상과 반대로, 효능에 있어서 이러한 반응의 개시는 질병 진행의 대체 척도와 비교할 때 상대적으로 느렸다; 그의 효과는 질병 진행에 대해 단기간 생존 (즉 무진행 생존)보다는 장기간 생존(즉 전체 생존)에 있어서 뚜렷하였다. 이러한 모든 발견은 관찰된 치료젓 잇점에 책임이 있는 제2의 작용 메카니즘의 존재를 가리키거나 (제2의 작용 메카니즘이라고 한 것은 이들이 암 세포 자체에 직접 작용하는 것이 아니라 종양 세포들의 증식과 전이에 책임이 있는 세포들 및 시그널링 경로에 작용하기 때문이다), 또는 더욱 가능성 높게는 수많은 제2의 작용 메카니즘의 종합적인 효과에 기인함을 가리킨다.

본 발명과 관련하여, 적어도 1종의 항종양제와 조합하여 임의 투여된 마시티닙은 통증과 관련된 암에 걸리거나 또는 비제한적인 예로서 다음에 기재된 것을 통한, 통증 관련 질병의 치료시 아편유사 진통제를 요구하는 암에 걸린 환자들의 부분모집단에서의 생존율을 증강시키는 것으로 보인다: 종양 미세환경의 조절 특히 비만세포 활성의 조절을 통한 종양 증식 제어; 면역자극-매개된 항암 효과의 조절; 및 항전이 효과. 이들 제2의 작용 메카니즘 각각에 대한 마시티닙의 효과의 연관성을 입증하는 직접 또는 추정적인 증거들이 존재한다.

특히 관련된 타당성은 마시티닙이 c-Kit에 대한 그의 저해 작용을 통해, 비만세포에 대해 직접적인 항증식 및 프로-세포자멸사 작용을 발휘함으로써 전-염증성 어레이 및 종양 성장과 종양 침습에 있어서 중요한 전-혈관형성 시토카인 및 케모카인을 감소시킨다는 사실이다. 그의 항증식 특성에 더해, 마시티닙은 또한 IgE 유도된 비만세포 탈과립화를 유도하는 트랜스덕션 경로의 핵심 성분들인 Lyn 및 Fyn의 표적화를 통해 비만세포의 활성화 역시도 제어할 수 있다 [Gilfillan, 2006; Gilfillan, 2009]. 이것은 인간 제대혈 비만세포의 FcεRI-매개된 탈과립화의 억제에서 관찰될 수 있다 [Dubreuil 등, 2009]. 마시티닙은 또한 조절되지 않을 경우 몇가지 인간 암에 있어서 종양 진행 및 불량한 예후와 관련된 키나제인 DDR1과도 강력하게 상호반응한다 [Davis 등, Nat Biotechnol 2011, 29(11): 1046-51]. 마시티닙은 따라서 종양 세포의 귀소 및 집락화를 둔화시킬 수 있다.

비만세포에 의한 침윤을 비롯하여, 염증 세포의 동원이 종양 침습성을 증대시키는 분자들의 생산을 통해 암의 성장 및 확산을 용이하게 한다는 증거들이 있다. 따라서, 비만세포 기능을 저해하는 것이 췌장암을 비롯한 암의 성장을 억제하는데 치료적으로 유리한 것으로 증명될 수 있다. 또한, 만성 염증성 질환의 면역병리학적 메카니즘에 있어서 필수적인 역할을 갖는 비만세포의, 염증과 췌장암 발병 간에 관계가 있는 것으로 알려져 있다. 실제로, 비만세포는 마우스 모델에서 췌장암 종양발생의 발병과 직접적으로 연관되어 왔는데, 이 모델은 비록, 비만세포가 췌장암 발병에 기여하는 메카니즘이 명확치는 않으나, 종양 미세환경 내로의 비만세포의 침윤이 높은 수준으로 일어날 경우 임상 결과가 좋지 않을 것임을 예측할 수 있게 한다는 것을 보여주었다 [Chang DZ 등, Clin Cancer Res 2011;17:7015-7023].

종양발생, 질병 진행, 및 전이 과정을 통해, 국소적인 숙주 조직의 미세환경은 활성적인 참여 요인으로서 암세포 증식, 혈관생성, 침습 및 생존 정도를 결정짓는다. 암의 종양발생에 있어서 비만세포의 역할은 잘 이해되고 있지는 않으나, 국소적인 기질 조건에 따라 또는 방출된 매개자가 종양 세포의 증식을 도와 악성종양 세포의 세포자멸사를 유도하는지에 따라, 비만세포가 종양발생에 이로운지 아니면 종양발생을 방해하는지에 관하여 상반되는 데이터가 존재한다 [(Theoharides TC, 등, Trends Immunol 2004;25:235-41); (Samoszuk M, 등, BMC Cancer 2005;21:121); (Almholt K, 등, Recent Results Cancer Res 2003;162:31-42); (Gooch JL, 등, Cancer Res 1998; 15:4199-205)].

췌장암의 종양 진행 및 침습에 있어서 비만세포의 역할, 그리고 암성 통증에 있어서 비만세포의 신흥 역할과 관련한 과학적 증거의 실체는 AB07012 연구로부터 본 발명자들의 연구에 신뢰성을 부여한다. 또한, 특정 이론에 구속되는 것은 아니나, AB07012 연구로부터 얻어진 데이터는 비만세포 활성화, 췌장암 병인, 및 췌장의 암성 통증 사이에는 이전까지 인식되지 않았던 어떤 연결관계가 존재함을 가리킨다. 즉, 췌장암에 있어서 불량한 임상 결과와 비만세포 활성의 상관관계, 암성 통증과 불량한 임상 결과의 상관관계 및 비만세포 활성과 암성 통증 사이에는 상관관계가 존재한다. 따라서, 췌장암에 있어서 질병 관련 통증의 개시는 비만세포 활성의 마커 역할을 할 수 있고, 이것은 다시 그 암의 발병에 있어서 보다 공격적인 단계로 되었음을 신호하는 것이다. 이 시나리오에서, 본 발명자들은 암환자들, 특히 췌장암 환자들의 질병 관련 통증이 어느 정도, 종양 미세환경에서의 암-유도된 신경병리학적 변화의 부산물이라 생각하며; 여기서 상기 변화는 질병 진행과 전이를 추진하는데 책임이 있는 변화이며 비만세포의 동원 또는 비만세포 활성화 증가와 관련된 변화를 의미한다.

본 발명과 관련하여, 질병 관련 통증의 시기와 위중도는 암 발병의 마커로서 간주할 수 있으며, 비만세포 활성의 증가는 종양 진행 및 질병 관련 통증 두 가지 모두에 있어서 적어도 부분적으로 책임이 있는 것으로 간주할 수 있다. 따라서, 비만세포 활성의 억제는 질병 관련 통증이 있거나 질병 관련 통증의 치료를 위해 아편유사 진통제를 필요로 하는 암 환자들의 부분모집단에 있어서 권장할 만한 치료 표적이다. 이것은 겜시타빈과 조합 투여된 마시티닙이 질병 관련 통증을 수반하는 췌장암 환자의 부분모집단에서 전체 생존율을 증가시켰다는 예기치 못한 발견으로부터도 자명하다. 이에 더해, AB07012 연구 결과는 질병 관련 통증이 없고 질병 관련 통증 치료를 위해 아편유사 진통제를 필요로 하지 않는 췌장암 환자의 부분모집단에서는 마시티닙 플러스 겜시타빈이 전체 생존율을 감소시켰음을 보여주었다. 따라서, 통증 강도의 예측변수 인자에 따라, 그리고 다른 독립적인 예측변수 인자의 부재하에서는, 이 후자의 부분모집단의 환자들을 마시틴집으로 치료하는 것은 권장되지 않는다.

따라서, 일반적인 췌장암 모집단으로부터 매우 특징적인 하나의 부분모집단이 적어도 1종의 항종양제(특히 겜시타빈)과 조합 투여되는 본 발명의 적어도 1종의 화합물 (즉, 티로신 키나제 저해제, 비만세포 저해제 또는 c-Kit 저해제, 특히 마시티닙)에 의해 이득을 얻는 것으로 나타났다. 이 부분모집단은 질병 관련 통증 강도의 평가에 의해 동정될 수 있는데; 예를 들어, 0이 아닌 시각상사척도(VAS) 통증 강도 점수가 적어도 1번 나타나거나 (특히 VAS > 20의 컷오프를 갖는, 예컨대 100 mm 스케일에서 20 mm 보다 높은), 또는이 통증 강도 역치와 균등한 척도를 나타내는 통증 강도를 나타내는 것으로 동정되나 이에 한정되지 않는다.

몇 가지 생화학적 마커들이 통증과 연관되어 있는데, 이러한 마커들 중 하나 이상은 전술한 통증 강도 예측변수 인자를 객관적으로 뒷받침하는 대체적인 마커 역할을 할 수 있다. 이러한 생화학적 마커의 예로는, 신경성장인자(NGF), 브래디키닌, 트립타제, 히스타민, 뉴로트로핀-3(NT-3), 및 뇌-유도된 향신경인자(BDNF)를 들 수 있으나 이에 한정되지 않는다. 그러나, 통증의 생화학적 마커들은 다양한 것으로 알려져 있고, 현재까지 이들이 질병 관련 통증을 경험하는 암 환자들을 정량적으로 동정할 수 있다는 결정적인 증거도 없다. 마찬가지로, 비만세포의 공지의 생체내 생화학적 마커들, 예컨대 비제한적인 예로서 절대적인 비만세포 카운트 또는 트립타제 수준은 비만세포 활성화와의 관련성이 저조한 것으로 나타났다 [Hermine O, 등, PLoS ONE. 2008;3:e2266]. 따라서, 비만세포 활성화 또는 질병 관련 통증의 신뢰할만한 대안적인 생화학적 마커의 부재하에서는, 비록, 일차원 툴이 통증 강도의 비고적 주관적인 척도를 나타내거나 비만세포 관련성의 간접적인 증거만을 제시할 뿐이기는 하지만, 그나마 이용가능한 가장 적절한 통증 평가 옵션으로 남아있다.

본 발명과 관련하여, 비만세포 활성 증가, 암에서 임상 결과 불량, 질병관련 통증이 동시에 발견되는 경우에는, 비만세포의 동원 또는 비만세포 활성화의 증가와 관련된 다른 암들에 대해서도 본 발명의 발견을 일반화시키는 것이 가능하다. 분명한 것은, 질병관련 통증의 개시는 비만세포 활성의 마커 역할을 하고, 이것은 다시 질병의 진행과 전이를 추진하는데 책임이 있는 종양 미세환경에 있어서의 변화를 가리키는 것이다. 그러나, 어떤 주어진 암에 있어서 질병관련 통증의 개시를 수반하는 생체내 비만세포 매개된 종양발생 및 전이와 관련한 현재의 지식 부재로 인해, 통상의 기술자는 체험적인 '시행착오'를 넘어서서, 통증과 관련한 암을 치료하는데 비만세포 활성의 표적화 원리를 적용하는 것이 불가능하다.

통증 강도 예측변수 인자를 통해 규정된 환자 부분 모집단의 치료와 관련한 AB07012 연구의 주요한 발견사항을 이하에 요약하였다 (또한 실시예 1 참조).

'통증'과 관련된 췌장암을 갖는 부분모집단을 이 연구에서 베이스라인 시각상사척도(VAS) 통증 강도 점수가 20보다 큰 환자들 (즉, 100 mm 스케일에서 측정시 VAS > 20 mm)인 환자들로 정의하였다. 이 선형 스케일은 환자에 의해 지각되는 통증 크기를 시각적으로 나타내준다(도 2). 이러한 크기는 레퍼런스 마크가 없는 100 mm 길이의 선으로 표시되었다. 한쪽 말단은 통증이 없음 (0 값)을 나타내고 다른 쪽 말단은 상상할 수 있는 가장 심한 통증 (100 값)을 나타낸다. 베이스라인에서 각 환자들로 하여금 그들이 겪은 통증 강도 수준을 VAS 스케일 위에 수직으로 선을 그어 표시하도록 한다. 통증이 없거나, 통증이 무시할 정도인 환자들은 VAS 스케일 상에서 0과 5 사이에 수직선을 긋도록 하였다.

여기서 표시된 모든 VAS 점수는 선형 스케일 상에서의 절대적인 크기를 나타내거나 백분율에 대응한다; 예컨대 VAS 통증 강도 점수가 20이면 이것은 100 mm 스케일에서 20 mm의 통증 수준을 가리키는 것이거나, 상기 스케일의 20%를 나타내는 것이다. 본 발명과 관련하여, 이 통증 강도 역치의 균등한 척도도 타당하다; 예컨대, 일차원 통증 강도 평가 툴 점수가 > 20%이면, 적어도 보통의 통증의 기준에 기초한 통증 카테고리화; 또는 적어도 보통의 통증의 다차원 통증 평가 툴 등급화를 가리키는 것이며, 이에 한정되지 않는다.

이 통증 강도 역치의 또 다른 해석은 상기 암 환자들이 적어도 보통 강도의 질병 관련 통증을 갖는다는 것이다. 전술한 구체예에서 통증 강도 예측변수 인자는 다음의 이유에 기초하여 정의되었다: (1) 이 역치는 연구 모집단의 중앙 통증 강도 (모집단의 50%)에 근사하였고 (가장 가까운 십 단위로 반올림됨); (2) 20 mm의 VAS 통증 강도는 사망에 대한 위험 비율에서 플래토 (또는 수평 점근선)의 출현과 동시적으로 일어났으며 (도 1 참조); (3) 이 역치는 종래 간행물에서도 통증 강도 컷오프로서 인용되었던 값이었음.

VAS 통증 강도 VAS >20이거나, 균등한 통증 강도 척도를 나타내는 부분모집단(이하 "통증 부분모집단"이라 칭함)에서, 겜시타빈은 마시티닙과 조합 투여되었을 때 최상의 결과를 나타냈다. VAS > 20의 통증과 연관된 췌장암 환자들에서 마시티닙 플러스 겜시타빈 조합에 있어서, 중앙 전체 생존율 및 사망 위험 비율 측면에서, 통계적으로 유의한 잇점이 관찰되었다.

VAS 통증 강도 VAS <5이거나, 균등한 통증 강도 척도를 나타내되, 질병 관련 통증의 관리를 위해 아편유사 진통제를 필요로 하지는 않는 부분모집단 (이하, "무통, 무모르핀(no morphhine) 부분모집단"이라 칭함)에서, 겜시타빈은 단독일 때 가장 우수한 효과를 나타냈는데 이는 다른 독립적인 예측변수 인자의 부재하에서, 이 부분모집단을 마시티닙 플러스 겜시타빈으로 치료하는 것은 권장되지 않음을 가리키는 것이다. '무통, 무모르핀' 부분모집단의 환자들을 마시티닙 플러스 겜시타빈으로 조합 치료한 경우, 중앙 전체 생존율 및 사망 위험 비율 측면에서 부정적인(negative) 치료적 잇점이 관찰되었다.

VAS 통증 강도가 5< VAS <20이거나, 균등한 통증 강도 척도를 나타내는 부분모집단 (이하, "중앙 미만 통증 부분모집단(below median pain subpopulation)이라 칭함"에서, 위험 비율에서는 통계적으로 유의적인 잇점이 있었으나, 중앙 전체 생존율 관점에서는 어떠한 차이도 관찰되지 않았다. 이 통증 강도 부분모집단에서는, 마시티닙과 겜시타빈과의 조합 사용으로 인해 생존율 측면에서 어떠한 위험이나 잇점의 증가가 관찰되지 않았는데, 이는, 이 부분모집단이 중성(즉, 마시티닙이 투여되어도 유해하지 않음)임을 가리키는 것이다.

마시티닙 플러스 겜시타빈 치료군에서는 위약 플러스 겜시타빈 치료군에 비해, '통증' 부분모집단에서 유해사례 (adverse event)로 인한 사망 빈도가 감소되었다 (2배 더 낮음) (즉 각각 10.9% 대 21.9%). 마시티닙 플러스 겜시타빈 조합의 독성은 마시티닙의 공지 안전성 프로파일과 일치하였으며 모두 관리가능하였고, 생명을 위협하는 유해사례의 위험성은 특히 심각한 중성구감소증에 대해 그의 발생을 옐견하여 적절한 프로토콜을 실시함으로써 크게 경감되었다.

본 발명의 가능한 한 가지 구체예에서, 췌장암 치료에 본 발명의 적어도 1종의 화합물을 사용하는 것은 비제한적인 예로서 다음의 가이드라인에 의존한다:

● 만일 환자가 적어도 1번, VAS 통증 강도 > 20 또는 이와 균등한 통증 강도의 '통증' 부분모집단 기준을 만족하면, 치료를 수행한다.

● 췌장암과 관련되지 않은 통증 제거를 위해 적어도 하나를 질문한다, 예컨대, 환자에게 그의 통증 위치를 표시하도록 요청할 수 있다.

● 다른 독립적인 예측변수 인자들의 부재시, '무통, 무모르핀'의 부분모집단은 치료하지 않는다는 규칙을 철저히 준수함으로써, 마시티닙 플러스 겜시타빈 조합이 유해한 것으로 나타난 환자들을 보호한다.

이러한 가이드라인은 통증 관련 증상을 유발할 수 있는 기저의 다른 병태들을 우선 배제한 다음, 환자의 통증을 평가하는 (환자에 대한 설문과 신체 검사를 통해) 확립된 진단 기준인 섬유근육통의 만성 통증 병태를 진단하는데 이용된 것들과 유사하다.

위험 비율에 있어서 통계적으로 유의적인 잇점이 없었던 중성 부분모집단 환자들('중앙 미만 통증', VAS ≤20, 또는 이에 균등한 통증 강도 측정값)은, 상기 치료가 권장되지 않은 부분모집단과 표시된 치료 부분모집단 사이에 커다란 완충지대를 제공한다. 치료에 기인하는 유해/무해 관점에서의 진단 결정은 효과적인 '이원적(binary)' 표시자가 되는데, '무통, 무모르핀'의 병태에서 '통증' (VAS > 20)과 크게 구별된다. '중앙 미만 통증' 부분모집단에 속하는 환자를 잘 못 치료한 경우에는, 생존에 유해하지는 않고, 다만 관리가능한 독성으로 인한 위험성만 증가할 뿐이다.

본 발명과 관련하여, 통증' 부분모집단 (VAS >20)에서 췌장암 환자에 대한 효과적인 치료 옵션은 존재하지 않는다. 이 진술의 신뢰성은, '통증' 및 '무통, 무모르핀' 부분모집단 간의 관찰된 생존 기간 차이가 10.0 개월 (즉, '통증' 부분모집단 환자의 생존 기간이 더 짧음)인 것으로부터, 단일 제제로서 겜시타빈을 투여받은 환자들의 생존 기간에서의 통증 강도 관련된 차이점을 나타내는 AB07012 연구 데이터로부터 강조된다 (실시예 1 참조). 또한, 엘로티닙 플러스 겜시타빈을 평가하는 연구에서, 균등한 '통증' 부분모집단에서는 생존 잇점이 보고되지 않은 반면 VAS 통증 강도가 <20인 부분모집단에서는 잇점이 분명히 나타났다. 마지막으로, '통증'이 있는 췌장암의 부분모집단 (VAS > 20)에 대한 폴피리녹스의 잇점은, 이 연구 분석에는 통증이 인자로 감안되지 않아 알려지지 않았는데, 췌장암 환자 생존에 미치는 통증 강도의 유의적 영향(AB707012 연구의 발견에서 밝혀진 바와 같음)에 비추어 볼 때, 이러한 생략은 폴피리녹스 생존 데이터에 부정적인 영향을 미쳤을 듯 하다.

AB07012 연구로부터의 추가적인 안전성 분석을 감안하면, 유해사례(AE)의 전체 빈도는 두 가지 치료군 모두에서 유사한 반면, 심각하고 위중한 AE 빈도는 위약 플러스 겜시타빈 치료군에서보다 마시티닙 플러스 겜시타빈 치료군에서 더 높았다. 위약 플러스 겜시타빈 치료군에서보다 마시티닙 플러스 겜시타빈 치료군에서 투약 중단, 일시적 간섭 및 투여량 감소가 더 자주 일어났다. 영구적인 중단에 이르게 한 유해사례는 각각 환자의 42% 대. 27% 였다 (p-값 = 0.002). 이들 중, 마시티닙 플러스 겜시타빈 치료군으로부터는 위중하지 않은 유해사례 AE로 인해 32%의 치료 중단이 있었고 마시티닙 플러스 겜시타빈 치료 환자에서는 오직 16%만이 투여량 감소가 보고되었다. 위중하지 않은 AE로 인한 치료 중단은 부분적으로는 마시티닙 투여량 감소를 보다 자주 이용하거나 마시티닙 출발 투여량을 저감시킴으로써 회피될 수 있었을 수 있다. 결과적으로, 연구 약물에 대한 노출은 마시티닙 플러스 겜시타빈 처리군에서 유의적으로 더 낮았다(p=0.001). 전체 모집단에서, 마시티닙 플러스 겜시타빈 치료군에서의 겜시타빈에 대한 환자 노출은 위약 플러스 겜시타빈 치료군과 비교할 때 약 35% 감소되었는데, 이는 다양한 통증 강도 부분모집단에서 관찰된 것과 유사한 추세였다. 안전성과 약물 노출에 대한 이러한 관찰 사항들을 취합하면, 마시티님 투여량 9 mg/kg/일은 부분적으로는 이 조합과 연관된 부가적인 독성으로 인해, 우수한 환자 순응성 관점에서 최적이 아니었다. 마시티닙의 추론된 작용 메카니즘에 대한 새로운 통찰을 고려하면, 6 mg/kg/일의 마시티닙 투여량이 최적의 개시 투여량인 것으로 여겨지며, 제한 독성 부재시, 부적절한 반응을 나타내는 환자에서는 투여량 증가가 허용된다.

본 발명자들은 또한 마시티닙 플러스 겜시타빈으로 치료된 췌장암 환자들에서의 생존율 개선을 위해 유전자 발현이 독립적인 예측변수 인자라는 것도 발견하였다. 따라서, 본 발명은 또한 인간 환자에 있어서 암의 치료방법에 관한 것이기도 하며, 상기 방법은 치료를 필요로 하는 환자에게, 티로신 키나제 저해제, 비만세포 저해제 또는 c-Kit 저해제, 특히 마시티닙 또는 약학적으로 허용되는 그의 염을, 임의로 1종 이상의 항종양제와 조합하여 투여하되, 상기 환자는 치료를 위해 우선적으로 유전자 발현 예측인자 변수에 기초하여 먼저 선택되는 것인 방법이다. 전체 생존 및 치료 효율을 예측하는 유전자 발현 패턴을 동정할 목적으로, 마시티닙 치료에 앞서서 말초혈액 세포 샘플의 RNA 발현의 부수적인 약리유전학 분석을 AB07012 연구와 병행하여 실시하였다. 게놈 분석(Skuldtech, Montpellier, France)은 차세대 서열분석(독립적으로 삼회 수행됨)의 고처리량 방법을 이용하는 RNA 발현의 전체 전사체 분석으로 이루어졌다. 이 분석은 AB07012 연구에 무작위화된 환자들의 부분모집단으로부터 유도된 혈액 샘플 중 다수의 유전자들의 발현 수준을 동시에 측정하였다. 분석은 우선 어떤 치료물질이 투여되었는지 관계없이 전체 모집단에 대한 연구에 대해 수행된 다음, 각각의 처리군, 즉 마시티닙 또는 위약 군 각각에 대해 분석함으로써, 치료에 따른 가능한 유전자 트렌드를 탐지하였다. 이 부수적인 연구의 목적은 위약 처리된 환자에 비해 마시티닙으로 처리된 환자들에 있어서의 생존기간 연장을 예측하게 해주는 바이오마커 (즉, 증가된 OS)를 밝혀내기 위한 것이었다.

특히, RNA 혈액 샘플을 채혈 및 분석하자, 환자의 55%에서 공격적인 질환이 진행중임을 가리키는 유전자 발현 프로파일이 분리되었는데, 이는 전체 생존율 뿐 아니라 치료를 잘 예측하게 하는 것이었다. 이 부수적인 약리유전학 데이터베이스는 치료 효과와 상관관계를 갖는 유전자 발현을 검출하기 위해 AB07012 연구에 무작위화된 119명의 환자들로부터의 혈액 RNA 샘플을 함유하였다 (치료군에 따라 1:1 비율). 제1 단게에서 치료 유형과 관련하여, RNA 발현 수준과 전체 생존율 사이의 가능한 관련성 관점에서 인간 전체 게놈 (~27,000 유전자)을 분석하였다. RNA 혈액 샘플을 PAXgene Blood RNA System을 이용하여 수집한 다음 다음 환자 프로파일에 속하는 4가지 풀의 RNA 샘플에 대해 3가지 독립적인 디지털 유전자 발현(Digital Gene Expression: DGE) 라이브러리를 구축하였다:

- ≤ 4 개월 생존한 마시티닙 플러스 겜시타빈 치료군의 환자들

- ≤ 4 개월 생존한 위약 플러스 겜시타빈 치료군의 환자들

- > 15 개월 생존한 마시티닙 플러스 겜시타빈 치료군의 환자들

- > 15 개월 생존한 위약 플러스 겜시타빈 치료군의 환자들

결과적인 게놈 데이터베이스는 119명의 변형된 배정된대로(intent-to-treat) 처리되니 환자들을 포함하였으며, 1.5-폴드 변화 < 10%의 p-값 기준으로 조정된 거짓 발견율로 edgeR 방법을 이용하는 감별 발현 분석(differential expression analysis)을 통해 이로부터 169개의 유전자가 동정되었다.

제2 단계로서, 실시간 정량적 PCR (실시간 정량적 폴리머라제 연쇄반응 또는 qPCR)을 실시하여, 어떤 유전자의 사이클 역치(Cycle threshold: Ct) 값을 구하였는데, 상기 값을 하우스키핑 또는 레퍼런스 유전자의 발현 수준에 대해 정규화시켜 델타Ct (DCt) 값을 얻었다. 하우스키핑 유전자는 정상적이고 병생리학적인 조건 하에서 생명체의 모든 세포에서 발현되는 유전자들이다. 이러한 유전자들은 보통 비교적 일정한 수준으로 발현된다. 좋기로는 정규화는 2가지 하우스키핑 유전자의 발현 수준에 기초하는 것이 좋고, 특히, 유전자 B2M 및 GAPDH의 발현 수준에 기초하는 것이 바람직하다. 따라서, 주어진 유전자의 Ct 값을 정규화하는데 2가지 하우스키핑 유전자(예컨대, 유전자 B2M 및 GAPDH)가 이용될 경우, 상기 유전자의 DCt는 다음과 같이 계산된다: DCt = Ct (유전자) - [Ct (B2M) + Ct (GAPDH)]/2. 높은 DCt 값은 상대적으로 더 낮은 유전자 발현 수준에 대응한다. AB07012 연구의 부수적인 약리유전학 연구의 주요한 방법론적 측면과 유전자 발현 예측인자 변수를 통해 정의된 환자의 부분모집단의 치료와 관련한 후속적인 결과를 다음에 요약하였다 (더욱 상세한 내용은 실시예 2를 참조할 것).

일 구체예에서, 유전자 발현 측정과 관련하여, 어떤 유전자의 발현 수준을 상기 유전자의 단백질 수준으로서 측정한다. 그 경우, 단백질 수준은 면역화학 또는 웨스턴-블롯 분석과 같은 항체-기반 검출법을 이용하여 측정하는 것이 바람직하다.

또 다른 구체예에서, 어떤 유전자의 발현 수준은 상기 유전자의 RNA 전사체 또는 cDNA의 수준으로서 측정된다. 그 경우, RNA 전사체(들) 또는 cDNA의 수준은 마이크로어레이, 정량적 PCR, DNA 칩, 표지되 프로브와의 혼성화, 또는 측면유동 면역분석법, 특히, 측면유동 딥스틱 테스트와 같은 핵산 기반 검출법을 이용하여 측정되는 것이 바람직하다. 좋기로는, 유전자의 발현 수준을 상기 유전자의 cDNA 또는 RNA 전사체 상에 행하여진 실시간 정량적 PCR에 의해 측정하는 것이 바람직하다. 실시간 정량적 PCR은 실시간으로 반응이 진행됨에 따라 증폭된 DNA가 검출되는 PCR 방식이다. 이 검출법은 형광 시그널의 축적을 통해 만들어진다. Ct(사이클 역치:cycle threshold)는 형광 시그널이 역치를 넘는데 필요한 PCR 사이클의 수이다 (즉, 배경 수준을 넘음). 따라서, qPCR에는 정방향 및 역방향 프라이머, 그리고 리포터, 좋기로는 DNA 형광 인터컬런트가 사용된다. 좋기로는 유전자 암호화 영역에서 혼성화에 특이적인 프라이머들을 사용하는 것이 바람직하다.

유전자 발현 예측변수 인자 세트를 정의하는데 사용된 방법론과 분석 공정, 그리고 그에 따라, 마시티닙이 치료적 잇점 관점에서 가장 유리할 환자 부분모집단에 대한 설명을 이하에 요약하였다.

- 이 분석법은 AB07012 연구에 무작위화된 총 119명의 환자로부터 채취된 말초혈액 세포에서 많은 수의 유전자들의 발현 수준을 동시에 측정하였다(마시티닙 처리 환자와 위약 처리 환자의 비율 1:1).

- 분석된 샘플들을 제0주(베이스라인)에 오직 한번 채취하였다.

- 환자의 혈액 샘플을 채취하기 위해 PAXgene

Blood RNA System을 이용하였고, 제조자의 권장사항에 따라 PAXgene Blood RNA Kit V.2 (PreAnalitix)를 이용하여 RNA를 추출하였다. RNA 통합성의 조절은 Eukaryotic Total RNA 6000 Nano Chip (Agilent Technologies)을 이용하여 2100 Bioanalyzer (Agilent Technologies, Palo Alto, USA)를 이용하여 수행하였다. RNA의 양은 NanoDrop ND-1000 분광광도계를 이용하여 조절하였다 . 정제된 RNAs를 -80℃에서 보관하였다.

- 디지털 유전자 발현(DGE) 실험을 수행하여 추정적인 바이오마커 세트를 선택하였다. 바이오마커 검정은 COBAS 플랫폼 (LC480, ROCHE Diagnostics) 상에서 실시간 PCR을 이용하여 실시하고, 적절한 생물통계 접근법을 이용하여 최상의 바이오마커를 선별하였다.

- Roche Diagnostics' 프로토콜에 따라 RNA를 역전사시켰다. 추정적인 바이오마커의 유전자 발현수준을 실시간 PCR로 조사하였다.

- DGE 분석 결과 119명의 변형된 배정된대로군 (intent-to-treat) 환자들의 게놈 데이터베이스로부터 수집된 169개의 유전자가 선택되었다.

- 각각의 유전자에 대해 DCt에 대한 세 가지 컷오프값이 특정되었다: 중앙, Q1 (제1 사분편차: first quartile, P25) 및 Q3 (제3 사분편차, third quartile, P75). By "중앙 DCt(Median DCt)"라는 용어는, 검사된 환자들 모두의 DCt의 중앙값을 의미한다. 각각의 컷오프에 있어서 (컷오프 미만/컷오프 초과), 다변량 모델을 이용하여 처리군들 간의 전체적인 생존율 차이를 설명하고자 하였다. 만일 처리군의 효과가 유의적이면 (p <5%) 조사 대상 유전자가 처리군에 따라 생존율에 상이한 효과를 미치는 것으로 결론지을 수 있고, 추가 분석에 그 유전자를 사용하였다. 유전자 KIT의 중요성으로 인해, 그의 유의성 수준과 관계없이 이 유전자를 선택하였다.

- 다변량 분석에 의해 후속적으로 총 64개의 컷오프값이 관련된 유전자들로 유전자 선택이압축되었다.

- 이들 64개의 유전자 및 이들의 대응하는 컷오프 값으로부터 가능한 모든 이원적-유전자 조을 다시 한번 다변량 모델에 적용하였다.

- Cox 모델에 제공된 카이-제곱 테스트의 p-값에 의해 측정된 조합의 식별력에 따라 각 조합을 분류하였다. 주어진 이원적-유전자 조합의 부가적인 유지 기준은 압축된부분모집단이 적어도 40명의 환자 (총 샘플의 1/3)를 함유하였는지이다.

- 동정된 6개 유전자 발현 예측변수 인자에서 발견된 10가지 개별적인 유전자들(즉, p- 값 <0.00001인 조절된 유전자 쌍들)은 다음과 같았다: ACOX-1, TNFRSFS10B, RPS23, ABCC3, LYN, HIF1ALPHA, ABCC1, IGJ, UBE2H, 및 PARP-2.

이 유전자들의 발현 수준을, 유전자 코딩 영역 내에서 혼성화에 특이적인 프라이머들을 이용하여, 실시간 정량적 PCR (실시간 정량적 폴리머라제 연쇄반응 또는 qPCR)에 의해 측정하였다.

■ ACOX-1 유전자의 경우, 프라이머는 뉴클레오타이드 73,938,893 및 뉴클레오타이드 73,939,007 사이의 17번 염색체 상에 위치한 서열을 증폭시킨다 (Assembly Feb. 2009 GRch37/hg19, UCSC source).

■ TNFRSF10B 유전자의 경우, 프라이머는 뉴클레오타이드 22,877,657와 뉴클레오타이드22,877,728 사이에 위치한 8번 염색체 상에 위치한 서열을 증폭시킨다 (Assembly Feb. 2009 GRch37/hg19, UCSC source).

■ RPS23 유전자의 경우, 프라이머는 뉴클레오타이드 81,571,951과 뉴클레오타이드 81,572,049 사이에 위치한 5번 염색체 상에 위치한 서열을 증폭시킨다 (Assembly Feb. 2009 GRch37/hg19, UCSC source).

■ ABCC3 유전자의 경우, 프라이머는 뉴클레오타이드 48,762,132와 뉴클레오타이드 48,762,221 사이에 위치한 17번 염색체 상에 위치한 서열을 증폭시킨다 (Assembly Feb. 2009 GRch37/hg19, UCSC source).

■ LYN 유전자의 경우, 프라이머는 뉴클레오타이드 56,854,522와 뉴클레오타이드 56,860,210 사이에 위치한 8번 염색체 상에 위치한 서열을 증폭시킨다 (Assembly Feb. 2009 GRch37/hg19, UCSC source).

■ HIF1A 유전자의 경우, 프라이머는 뉴클레오타이드 62,214,901과 뉴클레오타이드 62,214,976 사이에 위치한 14번 염색체 상에 위치한 서열을 증폭시킨다 (Assembly Feb. 2009 GRch37/hg19, UCSC source).

■ ABCC1 유전자의 경우, 프라이머는 뉴클레오타이드 16,177,368과 뉴클레오타이드 16,180,772 사이에 위치한 16번 염색체 상에 위치한 서열을 증폭시킨다 (Assembly Feb. 2009 GRch37/hg19, UCSC source).

■ IGJ 유전자의 경우, 프라이머는 뉴클레오타이드 71,521,360과 뉴클레오타이드 71,521,432 사이에 위치한 4번 염색체 상에 위치한 서열을 증폭시킨다 (Assembly Feb. 2009 GRch37/hg19, UCSC source).

■ UBE2H 유전자의 경우, 프라이머는 뉴클레오타이드 129,470,836과 뉴클레오타이드 129,470,925 사이에 위치한 7번 염색체 상에 위치한 서열을 증폭시킨다 (Assembly Feb. 2009 GRch37/hg19, UCSC source).

■ PARP-2 유전자의 경우, 프라이머는 뉴클레오타이드 20,825,213과 뉴클레오타이드 20,825,283 사이에 위치한 14번 염색체 상에 위치한 서열을 증폭시킨다 (Assembly Feb. 2009 GRch37/hg19, UCSC source).

일 구체예에서, 실시간 정량적 PCR 수행에 다음의 프라이머들을 이용할 수 있다:

사용된 2개의 하우스키핑 유전자들은 B2M 및 GAPDH였다. B2M 유전자의 경우, 증폭된 서열은 뉴클레오타이드 45,010,919와 뉴클레오타이드 45,010,990 사이의 15번 염색체 상에 위치한다 (Assembly Feb. 2009 GRch37/hg19, UCSC source).

GAPDH 유전자의 경우, 증폭된 서열은 뉴클레오타이드 6,643,999와 뉴클레오타이드 6,645,738 사이의 12번 염색체 상에 위치한다 (Assembly Feb. 2009 GRch37/hg19, UCSC source).

실시간 정량적 PCR의 수행을 위해, 프라이머, 사이즈(좋기로는 80 및 150 뉴클레오타이드 사이), Tm (융점, 좋기로는 60℃±1℃), GC% (G 또는 C 뉴클레오타이드의 백분율, 좋기로는 3'에서 ~60%), 3' 및 5' 자가-상보성 및 안정성(좋기로는 4 뉴클레오타이드에 못 미침), 생성물 크기 범위 및 열역학적 파라미터들(프라이머 Tm 및 나트륨 염 농도에 따른 2차 구조 변화)를 선택하여 동시 검출하는 것이 유리하다.

- 이들 10개의 유전자와 6개의 유전자 발현 예측변수 인자들을 동정하여, 풀링(pooling) 전략을 최종 수행함으로써 가장 흔하고/특이적인 유전자 발현 프로파일을 동정하고 개별적인 변형이나 이상점(outliers: 예컨대, 샘플 조작 실수에 기인하는 것)은 폐기하였다. 샘플 풀링은 어떤 명확한 결론을 도출하기에는 개별적인 연구 규모가 너무 작은 경우 전염병학에서 빈번히 사용되는 방법이다.

- 따라서, 가장 유의적인 이원-유전자 조합을 먼저 선택하고 이어서 다음의 정보를 기록하였다: 부분모집단 중의 환자 수, 위험 비율(HR); Cox 모델의 p-값. 이어서, 두 번째로 유의적인 이원-유전자 조합을 추가하여 샘플 크기와 분석력을 증강시켰다. 전술한 것과 동일한 정보를 기록하였다. 위험 비율 및/또는 p-값이 유지된 조건으로 새로운 조합 추가 후에 추가적인 환자들이 전혀(또는 거의) 추가되지 않을 경우 선별 과정을 중단시켰다 (실시예 2, 표 5 참조).

- 이원-유전자 조합의 최종 6 가지 조합(총 66명의 환자들)이 다음과 같을 경우 (이하 개별적으로 "유전자 발현 예측변수 인자들" 또는 집합적으로 "유전자/전사체 지문"이라 칭한다) 프로세스를 중단하였다:

■ 환자들의 델타 사이클 역치값이 ACOX-1의 경우 3.05 이하이고 TNFRSF10B의 경우 6.1 이하인, 유전자 ACOX -1 및 TNFRSF10B 의 동시적인 상향조절; (HR = 0.19, p-값 = 0.0091).

■ 환 자들의 델타 사이클 역치값이 RPS23 의 경우 0.35를 초과하고 ACOX -1의 경우 3.05 이하인, 동시적인 유전자 RPS23 의 하향조절 및 유전자 ACOX -1의 상향조절; (HR = 0.20, p-값 = 0.00046).

■ 환 자들의 델타 사이클 역치값이 ABCC3의 경우 4.3 이하이고 LYN의 경우 1.65 이하인, 유전자 ABCC3과 LYN의 동시적인 상향조절; (HR = 0.19, p-값 = 0.00025).

■ 환 자들의 델타 사이클 역치값이 HIF1A 의 경우 3.95 이하이고 TNFRSF10B 의 경우 5.65 이하인, 유전자 HIF1A 및 TNFRSF10B의 동시적인 상향조절; (HR = 0.19, p-값 = 0.00013).

■ 환 자들의 델타 사이클 역치값이 ABCC1 의 경우 3.5를 초과하고 IGJ 의 경우 7.05 이하인, 동시적인 유전자 ABCC1의 하향조절 및 유전자 IGJ의 상향조절; (HR = 0.19, p-값 = 0.000011).

■ 환 자들의 델타 사이클 역치값이 UBE2H의 경우 3.7을 초과하고 PARP-2의 경우 7.1을 초과하는, 유전자 UBE2H 및 PARP-2의 동시적인 하향조절; (HR = 0.192, p-값 = 0.000004).

여기서, 최적의 역치가 시험된 컷오프 값들에 근사하게 위치할 수 있고 환자 코호트가 일반적인 암 모집단만을 대표한다는 사실을 반영하기 위해, 상기 정의된 컷오프값에 대한 약간의 변형 역시 본 발명에 포함되는 것으로 이해되어야 한다 (예컨대, 명시된 컷오프값의 ±10% 또는 심지어 ±25%).

적어도 1개의 유전자 발현 예측변수 인자를 산생하는 것으로 동정된 부분모집단 (이하, "유전자 지문" 또는 " 전사체 지문" 부분모집단 (65명의 환자)이라 칭함)과, 그에 대응하는, 즉 어떠한 유전자 발현 예측변수 인자도 나타내지 않은 환자들의 부분모집단 (이하, "비유전자 지문" 또는 "비전사체 지문" 부분모집단 (53명의 환자)이라 칭함)에서 OS를 분석하였다.

"유전자 지문" 부분모집단에 대한 분석 결과 마시티닙 플러스 겜시타빈 처리군의 환자들은 평균 12.9 개월의 중앙 OS를 나타낸 반면, 위약 플러스 겜시타빈 치료군의 환자들은 4.7 개월의 중앙 OS를 나타낸 것으로 밝혀졌다 (다변량 분석).

베이스라인 특징의 차이점 조정 후, 중앙 OS의 차이는 통계적으로 유의한 것으로 입증되었으며(p-값 <0.000001) 사망 위험 비율(위약 플러스 겜시타빈 치료 하의 사망확률에 대한 마시티닙 플러스 겜시타빈 치료 하의 사망 확률로서 정의됨)은 95% 신뢰구간 [0.09;0.34]에서 0.17인 것으로 나타났다. 따라서, 전술한 유전자 발현 예측변수 인자들을 적어도 한 가지 나타내며, 따라서, 정의된 "유전자 지문" 부분모집단에 속하는 것으로 동정된 환자들은 겜시타빈 단독으로 치료된 환자들에 비해 마시티닙 플러스 겜시타빈의 조합으로 치료될 경우 사망 위험이 83% 감소된 것으로 나타났다. 보다 높은 신뢰구간 바운더리, 즉 0.34의 최악의 시나리오를 고려할 때, '유전자 지문' 부분모집단에서의 환자들의 사망 위험은 마시티닙 플러스 겜시타빈으로 치료시 여전히 66% 감소되었다. '유전자 지문' 부분모집단에 대한 카플란-마이어 평가결과 생존 확률은 여전히 더 높고 겜시타빈 단독 치료군에 비해 마시티닙 플러스 겜시타빈 치료군의 경우 생존율이 6 내지 24 개월 더 우수한 것으로 나타났다 (실시예 2, 도 7 참조).

이와 대조적으로, '비유전자 지문' 부분모집단에 대한 분석 결과는 위약 플러스 겜시타빈 치료군의 경우 중양 OS가 13.2 개월인데 반하여, 마시티닙 플러스 겜시타빈 치료군은 중양 OS가 5.6 개월인 것으로 나타났다 (다변량 분석). 중앙 OS의 이러한 차이는 통계적으로 유의하였으며(p-값 =0.000036) 사망 위험 비율(위약 플러스 겜시타빈의 사망 확률에 대한 마시티닙 플러스 겜시타빈의 사망 확률로서 정의됨)은 다변량 모델에서 [2.11:8.52]의 95% 신뢰구간에서 4.24인 것으로 나타났다 (실시예 2, 도 8 참조). 따라서, 전술한 유전자 발현 예측변수 인자들을 1개 이상 산생하지 않는 환자들의 사망 위험은 겜시타빈 단독으로 치료받은 경우에 비해 마시티닙 플러스 겜시타빈의 조합으로 치료받은 경우 더 높다. 따라서, 다른 긍정적인 예측변수 인자가 부재하는 상황에서, 상기 "비유전자 지문" 부분모집단의 상기한 치료는 권장되지 않는다.

게놈 데이터와 베이스라인 VAS 통증 강도 상태, , 통증 강도 예측변수 인자 사이에는 아무런 상관관계도 없는 것으로 관찰되었다. 이것은 '유전자 지문' 부분모집단과 '비유전자 지문' 부분모집단 양자 모두에 있어서, 즉 전체 게놈 모집단(119 환자)에 있어서 그러하였다. 본 발명과 관련하여, 따라서, 통증 강도 및 유전자 발현의 예측변수 인자들은 질병 진행의 독립적인 메카니즘과 연관되어 있는 것으로 추측되나, 특정 이론에 구애되는 것은 아니다. 따라서, 마시티닙을 이용한 치료는, 하나의 예측변수 인자에 대해서는 긍정적이지만, 다른 예측변수 인자에 대해서는 부정적인, 즉, 모순이 존재하지 않는 환자를 치료하는데 유리하다.

독립 예측변수 인자로서 유전자 발현을 고려할 때, 치료 관리 플랜은 적절한 유전자 지문을 갖는 것으로 동정된 환자들에게는 마시티닙을 임의로 적어도 1종의 항종양제와 임의로 조합하여 투여하되, 상기 유전자 지문이 결여된 환자들에게는 마시티닙을 투여하지 않는, 단순한 이원적 선택이다. 통증 강도 예측변수 인자에 대한 치료 관리 플랜은 보다 복잡하며 통증 강도와 기존의 치료법에 대한 상이한 역치를 고려하여 수행하여야 한다. 따라서, 본 발명의 일 구체예에서, 특이적이고도 독립적인 예측변수 인자들로부터 본 발명자들은, 도 3에 제시된 계획에 따라 췌장암 환자들에 대한 새로운 치료 관리 플랜을 제안하기에 이르렀다.

따라서, 첫번째 구체예에서, 본 발명은 티로신 키나제 저해제, 비만세포 저해제 또는 c-Kit 저해제, 특히 마시티닙 또는 약학적으로 허용가능한 그의 염을 임의로, 적어도 1종의 항종양제와 조합 투여하는 것을 포함하는, 치료를 필요로 하는 환자에 있어서 인간 환자의 암을 치료하는 방법에 관한 것이다.

본 발명의 화합물 및 적어도 1종의 임의의 항종양제는 별도로, 동시에 또는 순차적으로 투여될 수 있다.

특정 구체예에서, 상기 티로신 키나제 저해제, 비만세포 저해제 또는 c-Kit 저해제, 특히 마시티닙 또는 약학적으로 허용가능한 그의 염은 암 치료를 위한 적어도 1종의 항종양제와 조합 투여되는데, 여기서 상기 환자는 상기 적어도 1종의 항종양제에 대해 나이브하거나 상기 적어도 1종의 항종양제에 의한 치료에 반응하는 환자이다.

또 다른 구체예에서, 상기 티로신 키나제 저해제, 비만세포 저해제 또는 c-Kit 저해제, 특히 마시티닙 또는 약학적으로 허용가능한 그의 염은 암 치료용의 적어도 1종의 항종양제와 조합되어 투여되되, 상기 환자는 상기 적어도 1종의 항종양제에 대해 내성이 있거나 무반응성(불응성)인 환자이다.

본 발명은 또한, 적어도 1종의 항종양제와 임의로 조합되는, 전술한 방법을 위한 의약 조성물 또는 의약으로서 사용되기 위한, 상기 정의된 티로신 키나제 저해제, 비만세포 저해제 또는 c-Kit 저해제, 특히 마시티닙에 관한 것이기도 하다.

본 발명은 또한 임의로 적어도 1종의 항종양제와 조합되는, 전술한 바와 같은 티로신 키나제 저해제, 비만세포 저해제 또는 c-Kit 저해제, 특히 마시티닙을 포함하는, 전술한 설명 및 실시예에 정의된 바와 같이 암 치료 방법에 사용되기 위한 키트에 관한 것이기도 하다.

일 구체예에서 본 발명은 티로신 키나제 저해제 또는 비만세포 저해제가: c-Kit, PDGFR, Lyn, Fyn 및 DDR1의 티로신 키나제로부터 선택된 것인 키나제 활성의 저해제인 것인 전술한 방법에 관한 것이다.

일 구체예에서, 본 발명은 상기 환자가 통증 강도의 예측변수 인자에 기초하여 치료 대상으로 초기 선택된 것인, 전술한 방법에 관한 것이다.

따라서, 일 구체예에서 본 발명은 인간 환자에서 통증과 관련되거나 질병 관련 통증의 치료를 위해 아편유사 진통제의 투여를 필요로 하는 암의 치료방법에 관한 것으로서, 티로신 키나제 저해제, 비만세포 저해제 또는 c-Kit 저해제, 특히 마시티닙 또는 약학적으로 허용가능한 그의 염을, 임의로 적어도 1종의 항종양제와 조합하여 환자에게 투여하는 방법에 관한 것이다.

일 구체예에서, 상기 환자는 만일 적어도 한번 상기 환자가 0이 아닌 시각상사척도 ( VAS ) 통증강도 점수 , 또는 통증 강도에 있어서 이와 대등한 측정치로 정의된 질병 관련 통증을 나타낸 경우, 지시된 치료 부분모집단에 속하는 것으로 고려된다.

또 다른 구체예에서, 상기 환자는 만일 적어도 한번 상기 환자가 5 보다 큰 VAS 통증강도 점수 (예컨대 100 mm 스케일 상에서 VAS >5 mm, 또는 5%); 또는 10 보다 큰 VAS 통증강도 점수 (예컨대 100 mm 스케일 상에서 VAS >10 mm, 또는 10%); 또는 20 보다 큰 VAS 통증강도 점수 (예컨대 100 mm 스케일 상에서 VAS >20 mm, 또는20%)으로 정의된 질병 관련 통증을 나타낸 경우, 지시된 치료 부분모집단에 속하는 것으로 고려된다.

또 다른 구체예에서, 상기 환자는 만일 적어도 한번 상기 VAS >20 통증 강도 역치와 대등한 측정치로 정의되는 질병 관련 통증을 나타낸 경우, 지시된 치료 부분모집단에 속하는 것으로 고려된다. 상기 환자는 또한 만일 적어도 한번 상기 환자가 보통 내지 참을 수 없는 통증으로 분류되는 질병 관련 통증을 나타낸 경우, 지시된 치료 부분모집단에 속하는 것으로 고려된다.

일 구체예에서, 개별적인 질병 관련 통증은 전술한 바와 같이 정의 및 평가된다.

또 다른 구체예에서 본 발명은 상기 환자가 통증과 관련되거나 질병 관련 통증의 치료를 위해 아편유사 진통제의 투여를 필요로 하는 췌장암에 걸리고, '통증'이 적어도 1번 20보다 큰 시각상사척도 (VAS) 통증강도 점수 (예컨대 100 mm 스케일에서 VAS >20 mm으로 측정되거나 또는 20%)를 나타낸 것으로 보고된 것인 치료방법에 관한 것이다.

일 구체예에서, 상기 환자의 치료는 만일 다른 독립적인 예측변수 인자가 부재할 경우, 상기 환자가 질병 관련 통증을 나타내지 않고 질병 관련 통증의 치료를 위해 아편유사 진통제를 필요로 하지 않을 경우 상기 환자의 치료는 권장되지 않는 것으로 여겨진다.

일 구체예에서 본 발명은 상기 환자가 유전자 발현 예측변수 인자에 기초해서 초기에 치료에 선택되는 것인 방법에 관한 것이다.

일 구체예에서, 상기 유전자 발현 예측변수 인자들은 상기 티로신 키나제 저해제, 비만세포 저해제 또는 c-Kit 저해제, 특히 마시티닙 또는 약학적으로 허용가능한 그의 염을 이용한 치료에 앞서 수집된 말초혈액세포 샘플에서의 RNA 발현 분석으로부터 유도된다.

일 구체예에서, 만일 본 발명의 화합물 투여 전에 수집된 말초혈액세포 샘플에서의 유전자 발현이 다음으로부터 선택된 적어도 2종의 유전자들의 동시적인 상향조절 또는 하향조절을 나타낼 경우, 상기 환자는 지시된 치료 부분모집단에 속하는 것으로 여겨진다: ACOX-1, TNFRSFS-10B, RPS23, ABCC3, LYN, HIF-1A, ABCC1, IGJ, UBE-2H, 또는 PARP-2. 예를 들어, 이원적-유전자 조합의 비제한적인 예로는: 유전자 ACOX-1 및 TNFRSF10B의 동시적인 상향조절; 동시적인 유전자 RPS23의 하향조절 및 유전자 ACOX-1의 상향조절; 유전자 ABCC3 및 LYN의 동시적인 상향조절; 유전자 HIF1A 및 TNFRSF10B의 동시적인 상향조절; 유전자 ABCC1 및 IGJ의 동시적인 하향조절; 유전자 UBE2H 및 PARP-2의 동시적인 하향조절을 들 수 있다.

마시티닙의 바람직한 염은 마시테닙 메실레이트이다.

또 다른 구체예에서, 본 발명의 화합물은 1일 투여량 4.5 내지 12.0 mg/kg/일로 투여되며, 좋기로는 출발 1일 투여량이 6.0 내지 7.5 mg/kg/일인 것이 바람직하다.

임의로, 본 발명의 화합물은 최대 12.0 mg/kg/일에 도달할 때까지 1.5 mg/kg/일씩 그 투여량을 증가시켜 투여되는 것이 바람직하다.

임의로, 본 발명의 화합물은 최대 4.5 mg/kg/일에 도달할 때까지 1.5 mg/kg/일씩 그 투여량을 증가시켜 투여되는 것이 바람직하다.

투여량 조정은 치료기간 동안 투여에 대한 반응과 독성 (두 가지 모두 약물 노출 시기 및 기간에 따라 변화할 수 있음) 사이의 균형을 최적화하기 위해 환자에 대해 복수회의 증가 및/또는 감소를 거치게 되는 역동적인 과정인 것으로 여겨질 수 있다. 만일 투여량을 증가시킬 경우, 임상 관찰에 따라 달라지는 기간 동안, 6.0 mg/kg/일의 투여량으로부터 출발하여 최대 12.0 mg/kg/일의 투여량에 도덜할 때까지 1 내지 2 mg/kg/일 씩 증분시킨다. 예컨대, 상기 티로신 키나제 저해제, 비만세포 저해제 또는 c-Kit 저해제, 특히 마시티닙 또는 약학적으로 허용가능한 그의 염, 및 좋기로는 마시티닙 메실레이트의단일 투여량 증가는 1 내지 2개월 걸릴 수 있다. 또한 본 명세서에서 상기 티로신 키나제 저해제, 비만세포 저해제 또는 c-Kit 저해제, 특히 마시티닙 또는 약학적으로 허용가능한 그의 염의 환자-최적화된 투여량의 치료적 잇점을 극대화하기 위해서, 1 내지 2 mg/kg/일 보다 적은 투여량 증분으로 투여량을 증가시킬 수도 있다. 적절한 경우, 독성 감소를 위해 투여량 감소 역시 고려할 수 있다.

본 명세서에서 표시된 모든 투여량은 활성 성분 자체를 기준으로 한 것이지 활성 성분의 염 형태에 대한 것이 아니다.

설명된 투여법에서 mg/kg/일 단위의 마시티닙 투여량이 활성 성분인 마시티닙의 양을 가리키는 것임을 감안할 때, 약학적으로 허용가능한 염인 마시티닙 메실레이트의 조성 변형은 상기 투여량 범위에 변화를 가져오지 않을 것이다.

본 발명의 상기 화합물은 경구 투여되는 것이 바람직하다.

본 발명의 상기 화합물은 좋기로는 하루에 두 번 투여된다.

유리하게, 본 발명의 용도 또는 방법은 티로신 키나제 저해제, 비만세포 저해제 또는 c-Kit 저해제, 특히 마시티닙 또는 약학적으로 허용가능한 그의 염의 유효량의, 3 개월을 초과하는, 좋기로는 6개월을 초과하는 장기 투여를 포함한다.

바람직한 일 구체예에서, 본 발명은 상기 정의된 방법에 관한 것으로서, 상기 티로신 키나제 저해제, 비만세포 저해제 또는 c-Kit 저해제, 특히 마시티닙 또는 약학적으로 허용가능한 그의 염은, 선택적으로 적어도 한 가지 항종양제와 조합하여, 절제불가능한 진행 또는 전이 선암종 췌장암 치료를 위해 투여되며, 상기 환자는, 유전자 발현 또는 통증 강도의 예측변수 인자에 의해 정의된 바와 같이, 이를 필요로 한다.

적어도 한 가지 항종양제는 암 치료용 약물일 수 있으며, 좋기로는 겜시타빈 (Gemzar

, Lilly), 엘로티닙 (Tarceva

, Roche), 파클리탁셀 (Taxol

, Abraxane

, Bristol-Myers Squibb), 폴피리녹스, 5-플루오로우라실 (5-FU), 카페시타빈, 시스플라틴, 옥살리플라틴, 이리노테칸, 류코보린, 및 이들 항종양제들의 조합으로 이루어진 군으로부터 선택된다.

구체적 일 구체예에 따르면, 본 발명은 췌장암 치료 방법에 관한 것으로, 티로신 키나제 저해제, 비만세포 저해제 또는 c-Kit 저해제, 특히 마시티닙 또는 약학적으로 허용가능한 그의 염이 선택적으로 겜시타빈과 조합하여 투여된다.

최선의 투여 요법에 있어서, 연령, 개별적 상태, 투여 형태 및 임상 환경, 상기 티로신 키나제 저해제, 비만세포 저해제 또는 c-Kit 저해제, 특히 마시티닙 또는 약학적으로 허용가능한 그의 염의 효율적 투여량에 따라, 췌장암을 갖는 인간 환자의 경우, OS당 4.5 내지 9.0 mg/kg/일, 좋기로는 하루에 두번 섭취한다. 췌장암을 갖는 성인 인간 환자에 있어, 상기 티로신 키나제 저해제, 비만세포 저해제 또는 c-Kit 저해제, 특히 마시티닙 또는 약학적으로 허용가능한 그의 염의 초기 투여량 6.0 to 7.5 mg/kg/일은 본 발명에 따른 바람직한 구체예인 것으로 밝혀졌다. 치료에 대한 반응 검사 후 반응이 부족하고, 독성 제한이 없는 환자의 경우, 상기 티로신 키나제 저해제, 비만세포 저해제 또는 c-Kit 저해제, 특히 마시티닙 또는 약학적으로 허용가능한 그의 염의 투여량을 최대 9.0 mg/kg/일까지 증가시키는 것이 안전하게 여겨질 수 있으며, 환자는 치료에 대해 이로운 효과가 있고 독성 제한이 없는 한 치료될 수 있다. 치료관련 독성을 경험하는 환자의 경우, 내성 없는 환자에 있어, 치료에 의해 이로운 효과가 있고 투여량에 독성 제한이 없는 한, 상기 티로신 키나제 저해제, 비만세포 저해제 또는 c-Kit 저해제, 특히 마시티닙 또는 약학적으로 허용가능한 그의 염의 투여량은 1.5 mg/kg/일씩 최소4.5 mg/kg/일까지 감소될 수 있다.

다른 일 구체예에서, 상기 티로신 키나제 저해제, 비만세포 저해제 또는 c-Kit 저해제, 특히 마시티닙 또는 약학적으로 허용가능한 그의 염은 초기 일일 투여량 6.0 내지 7.5 mg/kg/일로 투여되며, 겜시타빈은 환자 표면적에 대하여 주당 투여량 1000 ± 250 mg/m²으로 최대 7주간 연속적 초기 투여(3 주 내지 7주)로 투여되며, 그 다음 1주 동안 치료를 쉬고, 그런 다음 주당 투여량 1000 ± 250 mg/m²으로 3주 동안의 주기로, 매28일마다 투여된다. 겜시타빈에 있어, 상기 투여 요법에 대한 약간의 수정이 여기에 내포되어 있음이 이해될 것이다. 예를 들어, "매 28일마다"라 할 때, 1 주기는 3주간 치료하고 1주 동안은 치료를 쉬는 것을 의미한다.

구체적인 일 구체예에서, 본 발명의 조성물은 경구용 조성물이다.

이 기술분야의 숙련자에게 알려진 바와 같이, 투여 형태에 적절하게 다양한 형태의 부형제가 사용될 수 있으며, 그 중 일부는, 예를 들어, 목적 치료에서 유효 분자를 전체적으로 더 효율적으로 만드는 방출 프로파일을 증진함으로써, 유효 분자의 효율성을 증진할 수 있다.

따라서, 본 발명의 약학적 조성물은 다양한 형태, 더욱 구체적으로는 예를 들어, 주사가능한, 분말로 만들 수 있는, 또는 섭취가능한 형태, 예컨대, 근육주사, 정맥주사, 피하주사, 피내주사, 경구, 외용, 직장, 질, 눈, 코, 경피, 비경구 경로로 투여될 수 있다. 일 바람직한 경로는 경구 투여이다. 본 발명은 특히 약학적 조성물 제조를 위한 본 발명에 따른 화합물의 용도를 포함한다.

이러한 약물은, 이 기술 분야에 잘 알려진 약학적으로 허용가능한 담체를 사용하여 적절한 복용량으로 제형화될 수 있는, 경구 투여에 적합한 약학적 조성물의 형태를 가질 수 있다. 이러한 담체는 환자의 섭취를 위한 정제, 환제, 당의정, 캡슐, 액체, 겔, 시럽, 슬러리, 현탁액 등으로 약학적 조성물을 제형화하는 것을 가능케 한다. 상기 유효 성분에 추가적으로, 이들 약학적 조성물은, 약학적으로 사용될 수 있는 제제로 유효 화합물을 처리하는 것을 촉진하는 부형제 및 보조제를 포함하는, 적절한 약학적으로 허용가능한 담체를 포함할 수 있다. 또한, 제형 및 투여에 관한 방법의 세부사항은 Remington's 제약학(Maack Publishing Co., Easton, Pa.)의 최신판에서 찾을 수 있다.

실시예 1: 진행/전이 췌장암 환자를 치료하기 위한 겜시타빈과 조합한 마시티닙의 효능 및 안전성 평가를 위한 무작위, 위약-대조, 단계 3 연구

상기 적응증(indication)에서 겜시타빈과 조합하여 치료하는 마시티닙의 효능 및 안전성 평가를 위하여 AB Scicence에 의하여 수행된 췌장암에서의 발전 계획은 다음의 임상 연구에 기반한다: 연구 AB07012 "진행/전이 췌장암 환자의 치료에서, 겜시타빈과 조합한 위약에 대하여, 겜시타빈과 조합한 9 mg/kg/일의 마시티닙의 효능 및 안전성을 비교하는 전향적, 다중심, 무작위, 이중맹검, 위약-대조, 2-평행군, 단계 3 연구". 비맹검(unblinding)일에 해당되는 효능 및 안전성 분석 컷오프일은 2012년 3월 1일이었다.

AB07012 연구 모집단의 설명

배정된 대로의(intent-to-treat, ITT) 모집단은 이 연구 치료를 받았는지에 관계없이 전체 무작위 환자로 정의되었다. 수정된 배정된 대로의(mITT, modified Intent-To-Treat) 모집단은 잘 문서화된 비치료관련 원인 때문에 이 연구에서 조기에 탈락된 환자를 제외하고는 모든 ITT 환자를 포함한다. 연구 AB07012의 ITT 모집단은 2008년 11월 11일부터 2010년 7월 6일까지 등록된 353명의 환자로 이루어진다 (마지막 환자 포함됨): 마시티닙 플러스 겜시타빈 치료군에 175명의 환자 및 위약 플러스 겜시타빈 치료군에 178명의 환자. 5명의 환자를 제외한ITT 모집단으로 정의된 mITT 모집단에 대하여 임상 효능이 분석되었다. 마시티닙 플러스 겜시타빈 치료군에서 2명의 환자는 마시티닙과 겜시타빈을 모두 받지 않았다. 위약 플러스 겜시타빈 치료군에서 2명의 환자 중 한명은 위약과 겜시타빈 모두를 받지 않았고, 나머지 한 명은 겜시타빈은 받았으나 위약은 받지 않았다. 제외될 다섯번째 환자는 위약 플러스 겜시타빈 치료군에 속하였으나 췌장암을 갖지 않았다.

따라서, mITT 모집단은 348명의 환자로 이루어졌다:

- 마시티닙 플러스 겜시타빈으로 치료한 173명의 환자

- 위약 플러스 겜시타빈으로 치료한 175명의 환자

통증 강도의 예측변수 인자에 따라 임상 효능에 대하여 분석된 모집단의 설명

베이스라인(baseline) 특징, 치료 유형 및 효능 분석으로부터 세가지 부분모집단이 생겨났으며, 다음과 같이 정의되었다:

- '통증': 시각상사척도(VAS) 통증 강도 점수 >20로 정의되는 질병 관련 통증을 갖는 환자 (N=137: 마시티닙 플러스 겜시타빈 및 위약 플러스 겜시타빈 치료군에서 각각 64명 및 73명).

- '무통증, 무모르핀(no morphine)': VAS [0-5]이고 아편유사 진통제가 필요 없는 것으로 정의되는 질병 관련 통증을 갖는 환자 (N=68: 마시티닙 플러스 겜시타빈 및 위약 플러스 겜시타빈 치료군에서 각각 34명의 환자).

- '중앙 미만 통증': '통증' 및 '무통증, 무모르핀' 부분모집단에 속하지 않는 그밖의 모든 환자 (N=107: 마시티닙 플러스 겜시타빈 및 위약 플러스 겜시타빈 치료군에서 각각 57명 및 50명의 환자).

전술한 바와 같은 '통증' 부분모집단은 다음 이유에 기반하여 정의되었다:

- 연구 AB07012에서 전체 생존율(overall survival)에 대한 다변량분석으로부터, 전체 생존율에 영향을 주는 주된 요인(변수)로서 통증 강도가 정해졌다. 또한, 통증 강도의 변수 및 환자에게 투여된 조합 치료제 간의 상호작용이 발견되었다.

- 전체 생존율에 대한 연구 AB07012로부터의 결과는, 위약 플러스 겜시타빈과 비교하여, 마시티닙 플러스 겜시타빈이 VAS >20 mm의 통증강도과 관련된 췌장암 환자의 전체 생존율을 유의하게 증가시켰음을 보여 준다.

- 전체 생존율에 대한 결과는 위약 플러스 겜시타빈 치료군에서 OS(전체 생존율)는 감소하고 통증 강도는 증가하였음을 보여 준다.

- VAS 20 mm의 통증 강도는 사망 위험 비율에서 플라토(plateau) (또는 수평 점근선)의 출현과 일치하였다.

- Moore 등에 의한 췌장암 치료에 대한 유사한 연구에서, 20 mm의 VAS는 VAS 통증 평가 컷오프로 보고되었다. 이 연구에서, 엘로티닙 플러스 겜시타빈 조합은 VAS >20; 1.00의 위험 비율 (95%CI [0.78; 1.27])인 환자의 경우, 위약 플러스 겜시타빈을 받는 환자와 비교할 때 전체 생존율에 추가적 이점이 없는 것으로 나타났다. [Moore MJ, 등, J Clin Oncol. 2007 May 20;25(15):1960-6].

- 과학 문헌 중 몇 개의 다른 간행물이 20 mm에서 컷오프인 VAS 점수를 포함하는 임상 결과를 보고하였다.[(Marineo G. J Pancreas 2003; 4(1):1-10); (Zaza C, 등, J Pain Symptom Manage, 2002;24:526-542)].

이상에서 정의된 전체 모집단 및 세가지 통증 강도 부분모집단에서, 전체 생존율(OS)의 분석에 의하여 임상 효능을 평가하였다. 통증 강도는 시각상사척도를 사용하여 평가하였는데, 이는 환자에 의해 인식된 고통 진폭의 시각적 표현을 제공하는 선형 스케일이다. 진폭은 부호를 갖지 않는100 mm 길이의 선으로 표시되었다. 하나의 말단은 통증이 없음(0 수치)를 표시하고, 다른 말단은 상상할 수 있는 최악의 통증(100 수치)을 표시한다. 실제로, 임상 치료를 받기 전에(즉, 베이스라인에서) 각 환자는 느끼고 있는 통증 감각의 수준을 VAS 스케일의 수직선에 그려서 표시하라는 요청을 받았다. 베이스라인에서 무통증 또는 무시할만한 통증을 갖는 환자는 VAS 스케일에서 0 내지 5 사이의 수직선에 위치할 것이다.

연구 AB07012 에서 전체 생존율 효능 분석

전체 생존율은 이 연구의 일차적 종료점이었다. OS는 무작위 추출일로부터 문서화된 사망일까지 측정되었다. 사망이 관찰되지 않은 경우, OS에 대한 데이터는 환자가 생존한다는 것이 알려진 마지막 날짜에 검열되었다. 치료와는 독립적으로 전체 생존율에 영향을 줄 수 있는 변수를 결정하기 위하여, OS는 위약 플러스 겜시타빈 치료를 받아온 환자에 있어 각 베이스라인 특징에서 일변량(univariate) 분석을 통해 조사되었다. OS결과(5%에서 통계학적 유의, 데이터 기재 안함)에서 주된 차이점은 베이스라인 특징들: 통증 강도에 대한 VAS 스케일; 국소적 진행/전이 암; 알부민 수치 (정상 / 비정상); 및 췌장 체부에서 1기 종양의 위치에서 관찰되었다. 전체 생존율에 가장 큰 영향을 주는 변수는 통증 강도였다. 통증과 관련된 질병이 전에는 전체 생존율과 관련되어온 반면, 통증 강도가 전체 생존율에 가장 중요한 요인이라는 것은 전혀 알려지지 않았다. 따라서, 췌장암 환자의 전체 생존율에 대한 통증 강도의 영향은 주요한 발견으로 여겨진다. 이러한 변수들, 특히 통증 강도는 위약 플러스 겜시타빈 조합 치료제로 치료 받는 환자의 전체 생존율에 대한 영향을 뚜렷하게 나타내기 때문에, 베이스라인 특징에서 양 조합 치료군 사이의 차이점들도 역시 전체 생존율에 영향을 미칠 것이라고 기대된다. 전체 생존율에 대한 조합 치료의 효과를 알아내기 위해서는, 두 변수에 대해 계층화된 경우에서 조차(여기서는, 나라 및 전이/국소적 진행), 일변량 모델은 적합하지 않으며, 따라서, 다변량 Cox 모델로 대체되었다. 전체 생존율에 대한 다변량 Cox 분석으로부터 얻은 결과를 이하에 전체 모집단 및 세가지 VAS 통증 강도 부분모집단 기재한다('통증'; '무통증, 무모르핀'; 및 '중앙 미만 통증').

통증 강도 예측변수 인자를 결정하기 위한 다변량 전체 생존율 분석

전체 생존율 및 치료 효능에 대한 각 변수의 영향을 다변량 모델 구축을 통하여 조사하였는데, 여기서 변수는 변수의 삽입 및 유지 모두에 대하여 5% 역치를 이용하여 단계적 절차를 통해 선택되었다. 최종 다변량 모델은 다음의 요인들을 포함하였다:

- 치료의 유의성(significance) 수준과 관계없이 치료군

- "단계적" 다변량 모델로 선택된 요인: 국소적 진행/전이 암; 췌장 체부에서 1기 종양의 위치; 알부민 수치 (정상 / 비정상); 및 세가지 VAS 통증 강도 부분모집단에 주어진 VAS 통증 평가 (이상의 정의와 같음).

- Kaplan-Meier 추정(치료군 및 요인 양상에 의함)을 통하여 상호관계가 그래프로 확인되었다.

표 2는 전체 모집단에 대하여 다변량분석 Cox 모델에 의해 정해진 통계학적으로 유의한 변수를 요약한 것이다.

이 다변량 모델로부터 얻어진 결과는 전체 모집단에서 생존율에 대한 조합 치료의 효과가 없음을 보여 주지만, 다음 네가지 변수로부터 유의한 영향을 밝혀 냈다: 통증 강도 (p <0.001), 알부민 수치(p <0.001), 전이 또는 국소적 진행으로 종양 분류 (p = 0.016), 및 췌장 체부에서 1기 종양의 위치 (p = 0.021). 따라서, 이들 변수는 OS를 위한 다변량 모델에 남게 되었다. 놀랍게도, 이들 데이터는 베이스라인에서 상기 정의된 VAS 부분모집단에 따른 통증 강도가 췌장암 환자의 OA에 유의한 영향을 주는 중요한 변수라는 발견에 이르게 하였다. 따라서, 다변량분석은 전체 모집단에 대해 이전에 수행된 바와 같은 동일한 절차 후에, 베이스라인 VAS 통증 강도 부분모집단에 따라 부분모집단에서 수행되었다. 표 3은 전체 모집단 및 세가지 VAS 통증 강도 부분모집단 각각에 있어서 OS에 대한 다변량분석 결과를 요약한 것이다.

다변량분석 결과, 전체 모집단에 있어서, 마시티닙 플러스 겜시타빈으로 치료한 환자는 위약 플러스 겜시타빈 치료군 보다 나은 통계학적으로 유의한 생존 이점을 가지지 않음을 확인하였다. 베이스라인 통증 강도가 OS와 강한 연관성이 있다는 발견을 기반으로, 이 변수, 조합 치료 유형 및 전체 생존율 사이의 상호관계가 존재하는지 결정하기 위하여, 이 매개변수를 더 조사하였다; 즉, VAS 통증 강도 점수의 함수로서 OS가 양 치료군(마시티닙 대 위약)에 대하여 분석되었다. 서로 유사한 곡선들은 상기 두 가지 변수 사이에 상호관계가 없음을 의미하는 것인 반면, 분리된 곡선들은 상호관계가 있음을 의미할 것이다. '통증' 부분모집단에 대해 p-값 0.010, '무통증, 무모르핀' 부분모집단에 대해 p-값 0.041으로 증명된 바와 같이(표 3), 통증 강도를 평가하는 VAS 스케일 및 사용된 조합 치료 간에 유의하고 강한 상호관계가 있음이 밝혀졌다. 상호관계를 그래프로 확인하면, VAS>20인 환자에서 중앙 OS는 마시티닙 플러스 겜시타빈 치료군에 비하여 위약 플러스 겜시타빈 치료군에서 더 낮았다; 0.61의 위험 비율 (95%CI [0.42; 0.88]) (도 4). 반면에, VAS [0;5] 인 환자(즉, '무통증, 무모르핀' 부분모집단)에서 중앙 OS는 마시티닙 플러스 겜시타빈 치료군에 비하여 위약 플러스 겜시타빈 치료군에서 더 높았다; 1.63의 위험 비율 (95%CI [0.94 ; 2.85]) (도 5). 이는 암 환자에서 OS 분석을 위한 변수로서 통증 강도의 중요성을 부각시킨다.

전체 모집단에서, 전체 생존율에 대한 다변량분석은, p-값 0.740, 및 95% 신뢰구간으로 사망에 대한 위험 비율 0.90 (95%CI [0.71; 1.14])으로 OS에 대하여 조합 치료의 유의한 영향이 없음을 보여 준다. 마시티닙 플러스 겜시타빈 조합 치료제로 치료 받은 환자의 경우 중앙 OS는 7.7 개월(95%CI [6.1; 10.6])이었고, 위약 플러스 겜시타빈을 받은 환자의 경우 7.0 개월 (95%CI [5.8; 9.6])이었다. 6, 12, 18, 및 24 개월에서 OS 비율은 마시티닙 플러스 겜시타빈의 경우 각각 59.2%, 32.1%, 17.3%, 및 9.5%이고, 위약 플러스 겜시타빈의 경우 각각 56.0%, 28.5%, 14.5%, 및 7.5%이었다.

'통증' 부분모집단에서, (VAS>20으로 정의된 질병 관련 통증을 갖는 환자), 마시티닙 플러스 겜시타빈 조합은 위약 플러스 겜시타빈에 비하여 통증 강도 VAS 점수 >20 의 췌장암 환자의 전체 생존율을, p-값 0.01으로 증명된 바와 같이, 유의하게 증가시켰다. 사망에 대한 위험 비율 (위약 플러스 겜시타빈의 사망 확률을 초과하는(over) 마시티닙 플러스 겜시타빈의 사망 확률로 정의됨)은 0.61 (95%CI [0.42; 0.88])이었고, 이는 마시티닙 플러스 겜시타빈으로 치료한 환자의 경우, 위약 플러스 겜시타빈으로 치료한 환자와 비교하여 사망 위험이 39%만큼 유의하게 감소하였음을 의미한다. 더 높은 신뢰구간 범위, 즉 0.88의 최악의 경우를 고려할 때, '통증' 부분모집단 환자의 사망 위험은 마시티닙 플러스 겜시타빈으로 치료한 경우, 여전히 12% 만큼 감소하였다. 마시티닙 플러스 겜시타빈 치료군에서 중앙 OS는 8.1 개월인 반면, 위약 플러스 겜시타빈 치료군에서는 5.4 개월밖에 되지 않았다. 6, 12, 18, 및 24 개월에서의 생존율은 각각 마시티닙 플러스 겜시타빈 치료군에서 58.2%, 32.2%, 17.2%, 및 ≤6.4%, 대비 위약 플러스 겜시타빈 치료군에서는 43.9%, 17.8%, 7.8%, 및 ≤2.0%이었다. 이 부분모집단의 다변량 모델에 대하여 Kaplan-Meier 추정을 도 4에 도시하였다. 위약 플러스 겜시타빈 보다 우월한 마시티닙 플러스 겜시타빈 치료의 치료적 이점은 다변량 모델에서 뚜렷이 나타나는데, 여기서 마시티닙 플러스 겜시타빈 생존 확률은 지속적으로 더 높다.

'무통증, 무모르핀' 부분모집단(VAS [0-5]으로 정의되는 질병 관련 통증을 갖는 환자 및 질병 관련 통증을 치료하기 위한 아편유사 진통제를 필요로 하지 않는 환자)에서, 위약 플러스 겜시타빈 치료군은 마시티닙 플러스 겜시타빈 군과 비교하여 췌장암 환자의 전체 생존율을, p-값 0.041 및 사망 위험 비율 1.63 (95%CI [0.94; 2.85])로 증명된 바와 같이, 유의하게 증가시키는 것으로 나타났다. 이러한 다변량분석은, 그밖의 독립적인 예측변수 인자가 없을 경우, 통증이나 아편유사 진통제의 필요과 무관한 췌장암으로 손상된 환자의 치료에 있어 마시티닙 플러스 겜시타빈의 투여는 권장할 만한 일이 아니라는 결론을 지지한다. 이 부분모집단의 다변량 모델에 대한 Kaplan-Meier 추정을 도 5에 도시하였다.

부분모집단 '중앙 미만 통증' (즉, 5< VAS <20으로 정의되는 질병 관련 통증을 갖는 환자)에서, 치료는 다변량 Cox 모델을 통해 전체 생존율에 유의한 영향을 갖는 것으로 확인되었다; p-값 0.976, 및 사망 위험 비율 0.95 (95%CI [0.63; 1.41]). 따라서, 이 부분모집단은 중립적인 것으로 여겨진다. 이 부분모집단의 다변량 모델에 대한 Kaplan-Meier 추정을 도 6에 도시하였다. Kaplan-Meier 플롯(plot)으로부터, 생존 확률을 표시하는 두 개의 곡선이 거의 동일함이 확인되었으며, 따라서, '중앙 미만 통증' 부분모집단은 마시티닙 플러스 겜시타빈 치료에 대하여 중립적이다. '무통증, 무모르핀' 부분모집단에서 마시티닙 플러스 겜시타빈이 권장되지 않는 것을 고려할 때 이 사실은 중요하며, 그러므로, '중앙 미만 통증' 부분모집단은 치료 및 비치료의 역치 사이에, 생존에 해가 될 치료를 받는 환자의 위험을 크게 완충하는, 더 큰 완충 역할을 효과적으로 나타내는 것이다.

추가적으로, VAS >20으로 정의되는 질병 관련 통증을 갖는 환자는 통증을 관리하기 위하여 궁극적으로 아편유사 진통제를 필요로 할 수 있으며, 추후 통증이 VAS 점수 ≤ 5 mm 으로 감소될 수 있다는 것을 알게 되었다. 그러나, "무통증이지만 아편유사 진통제를 필요로 함"으로 정의된 환자의 부분모집단도 역시 중립적 부분모집단인 것으로 나타났다 (데이터는 기재 안함).

연구 AB07012 에 대한 안전성 분석

'통증' (VAS >20)를 갖는 환자의 부분모집단에서, 이상반응(AE)의 주기는 양 치료군에서 유사하였다(100%). 중증 AE의 주기 및 중증 AE는 위약 치료군 (각각 56.2% 및 71.2%)에서 보다 마시티닙 치료군 (각각 68.8% 및 85.9%의 환자)에서 더 높았다. 겜시타빈 종료 또는 컷오프로 이어지는 AE는 위약 플러스 겜시타빈군에서 보다 마시티닙 플러스 겜시타빈 치료군에서 더 자주 일어났다. 이러한 경향은 전체 모집단에서 반복되었다; 즉, AE의 주기는 양 치료군에서 유사하였고, 중증 AE의 주기 및 중증 AE뿐만 아니라 겜시타빈 치료의 종료 또는 컷오프는 위약 플러스 겜시타빈군에서 보다 마시티닙 플러스 겜시타빈 치료군에서 더 높았다.

위약 플러스 겜시타빈 치료군에 비하여 마시티닙 플러스 겜시타빈 치료군에서 겜시타빈에 대한 노출이 전체 모집단에서35%; '통증' 부분모집단에서 35%; '중앙 미만 통증' 부분모집단에서 30%; 및 '무통증, 무모르핀' 부분모집단에서 45%까지 감소하였다. 전체적으로, 마시티닙 플러스 겜시타빈 치료군의 환자는 마시티닙을 평균 3.0 개월동안 받은 반면, 위약 플러스 겜시타빈 군의 환자는 위약을 평균4.3 개월 동안 받았다. 따라서, 마시티닙 플러스 겜시타빈 군에서 연구 약물에 대한 노출이 유의적으로 더 낮았다(p=0.001). 연구 약물에 대한 더 낮은 노출은 연구 기간중 환자가 받은 약물 투여량의 강도에 의해 두드러진다: 마시티닙 플러스 겜시타빈 군에서 초기에 계획된 투여량의 80% 미만을 받은 환자는 34.7% 인 반면, 위약 플러스 겜시타빈 군에서는 환자의 17.1% 였음.

이상반응에 대한 관찰결과 및 약물 노출을 함께 고려해 볼 때, 투여된 마시티닙 투여량 9 mg/kg/일은 환자 순응도에 있어서 최적이 아닌 것을 알 수 있으며, 이는 부분적으로는 조합과 관련된 추가적 독성 때문이다. 마시티닙의 추론된 활동 메카니즘에 관한 새로운 시각까지 고려하면, 마시티닙 투여량 6 mg/kg/일은 최적의 초기 투여량이라 여겨지며, 부족한 반응을 갖고 제한된 독성이 없는 환자에게 투여량 증가를 허용한다.

통증 강도의 예측변수 인자에 따른 연구 AB07012 효능 결론

연구 AB07012의 한 가지 목적은 절제불가능한 국소적 진행 및/또는 전이 췌장암 환자의 치료에서, 마시티닙 플러스 겜시타빈의 효능을 위약 플러스 겜시타빈 효능과 비교하는 것이었다. 전체 모집단에서, 마시티닙 플러스 겜시타빈 치료는 환자의 중앙 전체 생존율에서 통계학적으로 유의한 개선을 보이지 않았다. 그러나, 서로 다른 베이스라인 특징들에 대한 다변량분석에서 통증 강도는 전체 생존율에 대한 예측 능력에 있어 유일한 가장 중요한 요인으로 밝혀졌다. 세가지 부분모집단은 다음의 기준에 따라 생겨났다:

- '통증': VAS >20

- '무통증, 무모르핀': VAS <5

- '중앙 미만 통증': VAS = ]5-20]

이들 부분모집단에 따른 계층화는 위약 플러스 겜시타빈(즉, 단일 약제로서 겜시타빈)을 받는 환자에 있어서, '통증' 부분모집단'에서 중앙 OS가5.4개월인 것과 비교하여, '무통증, 무모르핀' 부분모집단에서는 중앙 OS가 15.4 개월이었는데, 여기서 이 두 부분모집단 사이의 중앙 OS 차이는 10.0개월에 해당한다. 반면에, 마시티닙 플러스 겜시타빈 치료는 '통증' 부분모집단에서 중앙 OS가 8.1 개월, 위험 비율이 0.61 (95%CI [0.42;0.88])로서 유의하게 연장된 중앙 전체 생존율을 나타내는데, 이는 위약 플러스 겜시타빈 치료군과 비교하여 마시티닙 플러스 겜시타빈 치료군에서 사망 위험이 39%까지 감소하였음을 의미한다 (p-값 = 0.01). 위험 비율은 '무통증, 무모르핀' 부분모집단에서1.63 (95%CI [0.94; 2.85])으로서 반대이다(p-값 = 0.041). 따라서, 통증 강도의 예측변수 인자를 따르고, 다른 독립적 예측 인자가 없다면, 환자의 상기 치료는 '무통증, 무모르핀' 부분모집단에서 권장할 수 없다.

요약하자면, 본 발명자들의 분석은 통증 강도가 췌장암 환자에서 전체 생존율을 강력하게 예측한다는 발견에 이르게 되었다. 마시티닙 플러스 겜시타빈 치료의 조합은 적어도 한 번 이상 시각상사척도 (VAS) 통증 강도 점수가 20을 초과하는(예컨대, 100 mm 스케일에서 치수가VAS >20 mm, 또는 20%) 통증이 적어도 한 번 보고된 경우로 정의되는 부분모집단에서 효과적인 것으로 증명되었다. 이 부분모집단은 전체 생존율에서 예후가 가장 좋지 않았으므로, 의료적 필요를 가장 충족시키지 못하였다. 환자의 43.9%에 해당되는 '통증' 부분모집단에서, 중앙 OS는 위약 플러스 겜시타빈일 때 5.4 개월인 반면, '무통증, 무모르핀' 부분모집단에서는 15.4개월, 및'중앙 미만 통증' 모집단에서는 6.4 개월이었다. 마시티닙 플러스 겜시타빈 치료는 '통증' 모집단에서 전체 생존율을 유의하게 개선하였다: 위약 플러스 겜시타빈 치료군에서중앙 OS가 5.4 개월인 것과 비교하여, 8.1 개월이었다 (p-값 = 0.010). 위험 비율은 0.61 (95% CI of [0.42; 0.88])이었는데, 이는 대조 치료균과 비교하여, 마시티닙 플러스 겜시타빈으로 39%까지 사망 위험을 감소시켰음을 보여 준다. 12, 18, 및 24 개월에서 전체 생존율은 각각 32%, 18% 및 ≤6.4%이었고, 이에 비하여위약 플러스 겜시타빈 치료군에서는 각각 18%, 8% 및 ≤2.0%이었다.

실시예 2: 효능 예측 기준을 조사하기 위한 연구 AB07012 의 게놈 분석

게놈 데이터로부터 예측 기준을 정의하기 위하여 보조 약물유전체학(pharmacogenomics) 연구가 수행되었다. 즉, 연구 AB07012에서 무작위로 선택된 췌장암 환자 하부집합(subset)에서, 전체 생존율 및 임상 치료의 임상 효과와 연관성이 있을 수 있는 하향-조절되거나 또는 상향-조절된 유전자를 알아 내는 것이다. 유전자 발현 예측변수 인자를 통하여 정의된 환자 부분모집단의 치료에 대한 이 보조 연구의 주된 결과는 전술한 '발명의 상세한 설명' 항목에 나타나 있다. 여기에, 사용된 기법에 대한 추가적 또는 보충적 세부사항을 제공한다.

유전자 발현 분석을 위한 Skuldtech 프로토콜

마시티닙으로 치료하기 전에 수집된 말초혈 세포 샘플의 전체 전사체 해석을 포함하는 게놈 분석을 대량신속처리법(high throughput method) 및 차세대염기서열결정(독립적으로 3번 수행)을 이용하여 Skuldtech (Montpellier, France)에 의해 수행하였다. 발현이 전체 생존율 및 치료 유형과 연관성이 있는 유전자를 알아내는 것은 다단계 과정에 의존한다. Skuldtech프로토콜(단계 1 내지 7)로부터 선택된 발췌문을 이하에 기술하고, 그 다음에 선택적 유전자 발현에 대한 어떤 방법론적 측면에 대하여 일반적인 논의가 뒤따른다.

1. 샘플 수집 및 관리:

- 드라이아이스 내 PAXgene튜브에 환자의 전혈(발송자: LabConnect, USA)을 받아서 -80℃에 보관하였다.

- 수집된 튜브는 치료전의 119 명의 환자에 속하는 것이며, 0주(week)라고 명명한다.

- 치료전 119명의 환자의 혈액 샘플에서 전체 RNA를 추출하였고, 0주(week)라고 명명한다. 전사체 해석(바이오마커 시험)을 이 시점에서만 수행하였다.

- 모든 119개의 RNA 샘플을 분석하였다. 수집된 샘플 중 몇개가 품질이 불충분한 이유로 분석이 불가능한 경우, 사용하지 않았다.

- 디지털 유전자 발현(DGE) 실험을 수행하여 추정되는 바이오마커의 집합을 선택하였다.

- 바이오마커 확인은 COBAS 플랫폼(LC480, ROCHE Diagnostics)에서 실시간 PCR을 사용하여 수행되었고, 최선의 바이오마커를 걸러내기 위하여 적절한 바이오통계학적 접근법이 사용되었다.

2. RNA 샘플:

- PAXgene 혈액 RNA 키트 V.2(PreAnalitix)를 사용하여 제조사의 권고에 따라 혈액(PAXgene 혈액 수집 튜브, BD)으로부터 베이스라인 혈액 샘플에 해당하는119개의 혈액 RNA 샘플을 추출하였다.

- 진핵 전체RNA 6000 나노칩(Agilent Technologies)을 사용하여2100 바이오분석기(Agilent Technologies, Palo Alto, USA)를 통해 RNA 무결성 제어를 수행하였다. NanoDrop ND-1000 분광광도계를 사용하여 RNA 양을 제어하였다. 정제된 RNA를 -80℃에서 보존하였다.

3. DGE 라이브러리 구축 및 유전자-표식(tag-to-gene) 지도작성:

환자의 혈액 RNA 샘플 풀로부터 12개의 디지털 유전자 발현(DGE) 라이브러리을 구축하였다. 4개의 치료군(즉 위약/겜시타빈 P, 또는 마시티닙 + 겜시타빈 M, 및 4개월 전에 사망, M4, 또는 15개월 후까지 생존, M15) 각각에 대하여, 동일한 혈액 RNA 샘플 풀로부터 세개의 DGE 라이브러리를 구축하였다(세 개의 기술적 복제). 이들 라이브러리는 일루미나(Illumina)의 DGE 표식 프로파일링 키트를 이용하고5 ?의 전체 RNA(풀 내에서 각 RNA 샘플 간에 동량의 RNA)를 사용하여 제조자의 프로토콜(버전 2.1B)에 따라 구축되었다. 일루미나 파이프라인을 사용하여 염기서열분석법 및 염기해독(base calling)을 수행하였고, 정제 여과 후에 서열표(sequence tags)를 얻었다. 사용된 플랫폼은MGX (Montpellier, France)이다. 각 DGE 라이브러리에서 얻은 데이터는 표식 탐지, 표식 계수 및DGE 라이브러리 품질 평가를 위하여 바이오표식 소프트웨어(Skuldtech, Montpellier, France)를 통해 분석되었다(Piquemal D, 등, Genomics. 2002 Sep;80(3):361-71).

4. 표식 주석달기(annotation) 및 선택:

호포 사피엔스 서열을 편집한 지역 데이터베이스 및UniGene cluster의 잘 주석된 서열(Built#232, March 2012, NCBI)로부터 관련 정보를 얻었다. 이 데이터베이스의 각 서열에 대하여, (R1)의 3'-최근접 NlaIII 제한 지역(CATG) 상향에 위치하는 기대되는DGE 표식(표준 표식) 및 내부 위치에 위치하는 추정하는 표식(전사의3' 말단에서부터 시작하여 R2, R3 및 R4로 라벨링함)을 추출하였다(Piquemal D, 등, Genomics. 2002 Sep;80(3):361-71). DGE 라이브러리로부터 얻은 실험적 표식을 매치하고 가상 표식의 수집물을 이용하여 주석을 달았다(17bp에 대해 정확히 매치). 먼저, 가상 기준 표식(R1)으로 각 실험적 표식에 해당하는 것을 찾았다. 그런 다음, 매치되지 않은R2표식의 실험적 표식을, 그 다음 F3, 그리고 R4에 대하여 주석을 달았다. edgeR 방법(버전 2.6.9, Bioconductor)을 사용하여 DGE 실험을 분석하였다.

5. 실시간 PCR 을 위한 cDNA 합성:

SuperScript II 효소200 units (M-MLV RT Type, Invitrogen) 및 랜덤 프라이머250 ng을 사용하여, 제조사의 지침에 따라(10분간 25℃, 50분간 42℃, 15분간 70℃), 동일한 일자에 동일한 피펫 세트 및 동일한 머니퓰레이터를 사용하여, 전체 RNA 300 ng 가 들어있는 최종 반응 부피20 μl 내의 각각 119개의 RNA에 대하여 역전사를 수행하였다.

6. 실시간 PCR:

실시간 PCR (qPCR) 플랫폼(Roche Diagnostics)에서 타겟 유전자의 확인을 실시하였다. Roche Diagnostics의 LightCycler

1536qPCR 장치에서 DNA 그린 마스터 키트 및 실시간 준비 DNA 프로브 마스터 키트(Roche Diagnostics)을 이용하여 제조사의 지침에 따라 qPCR 실험을 수행하였다.

Sybr 그린 분석을 위하여, 최종 부피 2 μl의 반응 혼합물을 다음과 같이 준비하였다: LightCycler 1536 DNA 그린 마스터 5X (Roche) 0.4 μl, 브라이트 그린 20X (Roche) 0.1 μl, 셋업 컨트롤 20X (Roche) 0.1 μl, 50 μM 프라이머 커플(Eurogentec) 0.04 μl, DNAse RNAse 자유수 0.36μl 및 cDNA 매트릭스(1/50 최종 희석) 1 μl. 프로브 분석을 위하여, 최종 부피 2 μl의 반응 혼합물을 다음과 같이 준비하였다: 실시간 준비 DNA 프로브 마스터 5X (Roche) 0.4 μl, 콘트럴 셋업 20X 0.1 μl, 4 μM 포워드 프라이머(Eurogentec) 0.1 μl, 4 μM 역 프라이머(Eurogentec) 0.1 μl, 4 μM FAM/TAMRA프로브(Eurogentec) 0.1 μl, DNAse RNAse 자유수0.2 μl 및 1 μl의 cDNA매트릭스(1/50최종 희석). Agilent Bravo 자동 액체 핸들링 플랫폼으로 모든 피펫팅 단계를 실시하였다. PCR 프로그램은 95℃에서 1 분간의 첫번째 전배양 단계 후, PCR 50회 (95℃에서 2초 동안, 60℃에서 30초 동안)를 포함한다. 비특이 생성물 및 프라이머 다이머으로부터 특이 생성물을 구별하기 위하여, 온도를 60에서 95℃로 점차 증가시킴으로써 멜팅 곡선을 얻었다. 델타Ct (DCt) 방법(Livak KJ 및 Schmittgen TD. Methods. 2001 Dec;25(4):402-8)을 사용하여 qPCR 데이터를 분석하였다. 두개의 기준 유전자(하우스키핑)의 평균 Ct 값에서 Ct 값을 뺌으로써 타겟 유전자에 대하여 DCt 값을 결정하였다. 하우스키핑 유전자는 B2M(NM_009735, Mus musculus 베타-2 마이크로글로불린, mRNA) 및 GAPDH(NM_002046, 글리세르알데히드-3-포스페이트 디하이드로게나제, 전사 변수 1, mRNA + NM_001256799 호모사피엔스 글리세르알데히드-3-포스페이트 디하이드로게나제, 전사 변수 2, mRNA)이었다.

7. 전사체(transcriptomic) 프로파일:

DGE 방법을 사용하여 환자 전혈의 전사체 프로파일을 수행하였고, edgeR 방법으로 좋은(good) 마시티닙 반응자 및 나쁜(bad) 마시티닙 반응자 사이에 차별적으로 발현되는 유전자로서, 169개의 유전자를 선택하였다. (i) 최고의 차별 배수 변화(>1.5), 및type I (알파=5%) 에러에 기반한 FDR 조절 p-값 기준(<10%)으로 수학적 여과, 및 (ii) 특정 과정 및 공지된 대사과정에서 타겟 유전자에 관련된 생물학적 여과에 의하여, 분석된 유전자를 선택하였다. 실시간 PCR 분석에서, 형광 신호의 축적에 의하여 긍정적 반응이 감지되었다. Ct (사이클 역치)는 역치와 만나는(즉 자연수준을 초과하는) 형광 신호에 요구되는 사이클의 수로 정의된다. Ct 값은 샘플내 타겟 핵산의 양에 반비례한다(즉, Ct 값이 낮아질수록, 샘플내 타겟 핵산의 양이 증가한다).

전체 생존율의 유전자 발현 예측변수 인자를 확인하는 방법론

이 보조 연구의 목적은 (i) 위약 플러스 겜시타빈 치료 환자와 비교하여 마시티닙 플러스 겜시타빈 치료 환자에 대한 연장된 생존(즉, 증가된 OS)을 예측하는 바이오마커; (ii) 위약 플러스 겜시타빈 치료 환자와 비교하여 마시티닙 플러스 겜시타빈 치료 환자에 대한 조기사망(즉, 감소된 OS)을 예측하는 바이오마커를 알아내는 것이다. 이 분석은 동시에 연구 AB07012의 119명의 환자로부터 얻은, 마시티닙으로 치료 전에 수집된 말초혈세포 샘플에서 다수 유전자의 발현 수준을 측정하였다(마시티닙 플러스 겜시타빈 및 위약 플러스 겜시타빈 치료 환자는1:1 비율). 환자 혈액 샘플을 수집하고, RNA(리보핵산)를 분리하며, 배송을 위하여 드라이아이스에 포장하고 -80℃에 저장하기 위하여 PAXgene^TM 혈액 RNA 시스템이 사용되었다. PAXgene 튜브는 FDA 승인된 것이다(i.d. K042613). 분석된 샘플은 0주에서만 단한번 채취되었다(베이스라인).

일반적으로, 차별 유전자 발현은 재현성 및 실제 신규 유전자 발현 패턴의 감지에 있어서, 몇가지 과제가 있다. 예를 들어, 혈액 RNA 샘플의 분석은 실험적 및 개체간 가변성 때문에 다양한 오류에 부딪히게 된다. 또한, 관심 유전자의 사전선택은 전사체에 대한 기존 지식의 필요성에 의해 방해를 받을 수 있다. 다음의 방법들은 이러한 문제들을 해결하고, 최적의 재현성을 보장하기 위하여Skuldtech 에 의해 도입되었다:

- PAXgene^TM 혈액 RNA 수집 시스템은 부위별 서로 다른 수집 표준에 의해 RNA의 분해 및 샘플 품질의 차이를 방지한다.

- edgeR Bioconductor 분석 및RNA 샘플의 풀링을 통하여 내재적 유전자-특이 및 개체간 발현 가변성이 고려되었다.

- DGE 방법론은 관심 전사체에 대한 기존 지식에 의존하지 않으며, 따라서 어떠한 관심 환자군에도 적용될 수 있다.

- qPCR 실험을 위하여, 산업 및 연구 표준기술을 준수하는 기술 플랫폼의 현재 상태를 사용하였다.

첫번째 분석 단계는 edgeR [http://www.bioconductor.org/packages/2.9/bioc/html/edgeR.html]의 방법론을 이용하여 수행된 완전 DGE 분석을 포함하였다. 두번째 분석 단계에서, 실시간 PCR 실험, [www.bioconductor.org/packages/2.9/bioc/html/ddCt.html]에서R 패키지 ddCt을 이용하여 2^- ^ddCt (2exp - 델타 델타 사이클 임계값) 분석을 수행하였다. 이 분석은 선택된 유전자가 고전적인 임상 및 기술 특성을 충족할 것인지 검사하기 위하여 차별 컷오프를 위해 사용되었다. 이 연구에서 각 관심 유전자는qPCR에 의해 증폭되었고, 각 유전자 및 각 환자에 대하여 개별 일반화시킨 후, 델타 사이클 임계값(DCt)이라고 하는 산출된 매개변수를 검사하여, 그 결과 주어진 환자의 주어진 유전자의 발현 수준을 제공하였다. 두개의 기준(하우스키핑) 유전자(B2M, GAPDH)를 이용하여 Ct 값을 얻었는데, 이 값은 혈액 RNA 샘플들 전반에 걸친 DGE 분석에서 안정적 발현을 나타냈다. DCt는 기준 유전자의Ct 값의 기하 평균에서 사이클 임계값(Ct)을 뺌으로써 조사 중인 각 유전자에 대하여 정의된다. DCt 값은 유전자 발현 수준에 대하여 반비례한다: 그러므로, 상향 조절된 유전자의 경우, 더 낮은DCt 값은 더 높은 발현 수준을 표시하는 반면, 하향 조절된 유전자의 경우, 더 높은DCt 값은 더 낮은 발현 수준을 표시한다.

본 연구에 사용된 DGE(디지털 유전자 발현) 방법은 전사체 해석을 위한 대량신속처리 접근법이다. 이 방법은, 마이크로어레이로부터 얻는 간접적 아날로그 신호와 반대로, 관심 영역에서 서열 리드(read) 수로 표시되는 RNA양의 디지털 측정을 제공한다. 또한, 이는 더 넓은 다이나믹 범위를 가지며, 연구 중에 전사체에 대한 기존 지식을 갖는지 여부에 의존하지 않는다. 따라서, 이 방법은 신규한 전사, 및 대안적 증진제의 사용, 스플라이스 부위, 아데닐산중합반응의 결과로 주어지는mRNA 변수를 종합적으로 감지하는 능력을 갖는다.

DGE 라이브러리는 전체 RNA로부터 poly-A 선택에 의하여 분리된 mRNA으로 만들어진다. 라이브러리의 차후의 구축은 제조사의 프로토콜(버전 2.1B)에 따라 일루미나의 DGE 표식 프로파일링 키트(San Diego, USA.)로 이루어진다. 간단하게, RNA는 역전사를 위하여 무작위로 프라임되고, 그런 다음 두번째-가닥이 합성되어 2중가닥 cDNA 조각을 만든다. 그리고 나서, 각 RNA에 대한 특이적 21bp-표식이 추출되었다. 표식이 분리되었고, 특이적 어댑터가 라이게이션 되었으며, 그 다음PCR 증폭하였다. 라이브러리는 일루미나의DNA 서열 플랫폼(San Diego, USA)에 의해 서열화되었다. DGE는 절대값을 제공하고, 임의의 기준으로 조정하는 것을 필요로 하지 않으며, 그 결과 독립적 연구소에서 만들어진 다른 데이터와 비교될 수 있다.

인간 조작 및 세포 정제의 어색함에 의한 편견을 없애기 위하여, Skuldtech 전체 혈액에서 직접 리드를 선택했다. 따라서, 이 프로젝트의 첫번째 단계 중 DGE 방법에 의한 바이오마커의 선택 및 발견은 전체 혈액에 대하여 수행되었다. 마지막으로, 풀링 전략이 수행되었는데, 이는 개별 연구가 너무 작아서 명확한 결론에 이를 수 없을 경우 역학에서 자주 사용된다. 샘플 풀링의 주된 장점은 가장 보편적인/특이적 유전자 발현 프로파일을 알아내고 개별 편차는 제거하는 능력에 있다.

Roche Diagnostics의 프로토콜을 따라 RNA를 역전사하였다. LightCycler 480을 사용하여 실시간 PCR을 통해 추정 바이오마커의 유전자 발현 수준을 조사하였다. 실시간 PCR 실험의 기술적 효율을 검사하기 위하여 기준 유전자의 발현을 각각의 실시간 PCR 플레이트에서 정량화하였다. 각 실시간 PCR 실험과 관련된 Ct 값에서 편차는 기준 유전자 사이에서 평가되었다. 기준 유전자의Ct 값의 기하 평균에서Ct 값을 뺌으로써 모든 타겟 유전자에 대한 DCt 값이 결정되었다. 따라서, 데이터 매트릭스는 모든 실시간 PCR 다이나믹 분석에서 얻은 DCt 값을 기반으로 구축되었으며, 이는 추후에 모든 가설검정에서 사용되었다.

유전자 발현 예측변수 인자의 관심 유전자의 선택 및 발견

DGE 분석 결과, 119명의 수정된 치료 목적 환자의 게놈 데이터베이스로부터 169개의 유전자가 선택되었다. 이들 유전자의 선택은 전체 생존율에 대한 유전자, 예컨대, 마시티닙 플러스 겜시타빈 치료와 전체 생존율의 상호관계에 관련된 유전자의 영향에 기반하였다. 선택된 유전자 각각은 정성적 폴리머라제 사슬 반응(qPCR)에 의하여 증폭되었고, 개별 일반화 후, 주어진 환자의 주어진 유전자의 발현 수준이 평가되었다. 분석은, 기준 유전자 (B2M, GAPDH) 집합에 대하여, 각 qPCR 실험에 관련된 Ct 값의 변화에 기반하였다. 델타 Ct 값(DCt)은 기준 유전자의Ct 값의 기하 평균에서Ct 값을 뺌으로써 조사 중인 각 유전자에 대하여 정의되었다. 각 유전자에 대하여 컷오프가 구체화되었다: 중앙, Q1 (첫번째 분위, P25) 및 Q3 (세번째 분위, P75). 각 컷오프(컷오프 미만/컷오프 초과)에 있어서, 일차적 기준에 사용된 다변량 모델은 OS를 설명하기 위하여 위험-비율, Chi-squared 통계학 및Cox 모델의 p-값(유전자당 하나)을 계산하였고, 요인들: 치료군, 종양 상태, 종양 위치, 및 베이스라인에서의 알부민 수치를 사용하였다.

따라서, 각 유전자에 대하여 7개의 서로 다른 Cox 모델을 실시하였다:

- 모델에서 컷오프 원DCt 값 없음

- DCt 값 <중앙

- DCt 값 >중앙

- DCt 값 <Q1

- DCt 값 >Q1

- DCt 값 <Q3

- DCt 값 >Q3

치료군의 효과가 유의할 경우(p <5%), 조사 중인 그 유전자는 치료군에 따라 생존에 대한 효과가 다르다는 결론을 내릴 수 있다. p <5%인 경우, 조사 중인 유전자는 다음 단계를 위하여 선택되었다. 17개의 서로 다른 유전자로 이루어진, 전체37개의 유전자/컷오프 조합이 선택되었다.

상기 단계에서 선택된 17개의 유전자 각각에 대하여, 동일한 다변량 모델이 각 조합 및 각 컷오프에 대하여 사용되었다. 따라서, 각 유전자에 대하여 7가지 Cox 모델을 실시하였다. 적용된 규칙은, 조합에 의해 만들어진 부분모집단이 40명(전체 샘플의 1/3) 보다 많은 환자를 포함해야 한다는 것이었다:

이들 서로 다른 조합은, Cox 모델에서 제공된Chi-squared시험의p-값으로 측정된 조합의 차별적 파워에 따라 분류되었다. 여섯가지 가장 유의한(p-값s<0.01) 조합을 표 4에 나열하였다.

가장 포괄적인 전체 유전자 지문을 마무리하기 위하여, 가장 유의한 듀얼-유전자 조합을 먼저 선택한 다음, 다음의 정보를 기록하였다: 부분모집단 내의 환자수, 위험 비율; Cox 모델의 p-값. 다음으로, 샘플 크기 및 분석 파워를 증가시키기 위하여 또다른 듀얼-유전자 조합을 추가하였다. 상기와 같은 정보를 기록하였다. 위험 비율 및/또는 p-값이 유지되는 전제조건 하에, 신규 조합의 추가에 뒤따르는 추가 환자가 없을 때(또는 거의 없을 때) 선택 과정을 종료하였다. 표 5는 선택 과정을 요약한 것이다.

표 5. 치료군에 있어서, 듀얼-유전자 조합과 OA에 대한 통계학적으로 유의한 영향. 여섯가지 유전자 발현 예측변수 인자에 해당하며, 종합적으로 '유전자 지문' 부분모집단이라고 칭하는 가장 차별적인 듀얼-유전자 조합을 굵은 글씨로 나타내었다.

여섯가지 조합 후에 과정을 종료하였다. GBM를 지닌 것으로 인식되는 환자 중에서, 일부는 양 복제에서 모두 표식되었고(45명의 환자), 일부는 복사1에서는 표식되었지만 복사 2에서는 표식되지 않았고(11명의 환자), 일부는 복사2에서는 표식되었지만 복사 1에서는 표식되지 않았다(10명의 환자). 따라서, 최종 부분모집단은 총 66명(= 45+11+10)의 환자를 포함한다. 듀얼-유전자 조합의 최종 선택은 "유전자 발현 예측변수 인자"의 집합으로 구성된다 (종합적으로 "유전자 지문" 부분모집단이라고 칭함). 이들 유전자 발현 예측변수 인자는 다음과 같다: ACOX1<=3.05 및 TNFRSF10B<=6.1; RPS23>0.35 및 ACOX1<=3.05; ABCC3<=4.3 및 LYN<=1.65; HIF1A<=3.95 및 TNFRSF10B<=5.65; ABCC1>3.5 및 IGJ>7.05; UBE2H >3.7 및 PARP2>7.1.

상기 정의된 DCt 역치는 타겟 부분모집단을 구별하는 가장 포괄적인 전체 유전자 지문을 나타낸다. 그러나, 최적의 역치는 이들 컷오프에 근접하는, 예컨대 중앙값보다는 55%인 것으로 밝혀질 가능성이 있다. 게다가, 상기 정의된 역치는 일반 암 모집단의 대표로 생각될 수 있는 특정 환자 집단(n = 119) 에서 얻어지지만, 다른 집단에서도 전체 모집단의 대표 샘플이기 때문에 최적의 컷오프가 약간 달라질 것임이 예상되어야 한다. 따라서, 이들 유전자 발현 예측변수 인자와 관련된 컷오프를 정의하기 위하여, 약간의 수정이 여기에 포함되는 것이 이해될 것이다; 예를 들어, 기술된 컷오프의 ± 10%, 또는 기술된 컷오프의 ± 25%까지.

함께 고려할 때, 이들 6가지 유전자 발현 예측변수 인자는 연장된 생존에 있어서 마시티닙 치료에 긍정적인 치료 반응을 보일 확률이 높은 환자 부분모집단을 정의한다. 부분모집단은 일반적으로 암의 마시티닙 치료에 대한 '유전자 지문' 부분모집단으로 해석될 수 있다. 따라서, 전체 분석(베이스라인, 효능 및 안전성)은 '유전자 지문' 부분모집단(즉, 긍정적인 유전자 발현 예측변수 인자를 적어도 한개 갖는 환자)에 대하여 수행되었다. 추가적으로, 효능 분석은 유전자 발현 예측변수 인자에 부정적인 부분모집단(즉, '비유전자 지문' 부분모집단)에 대해서도 수행되었다.

유전자 발현 예측변수 인자에 따른 연구 AB07012 의 임상 효능의 검사

게놈 정보가 있는 환자 집단 전체(n = 119; 60명의 마시티닙 및 59명의 위약 환자)를 고려할 때, 중앙 OS는 양치료군에서 모두 7.7 개월이었고, 사망 위험 비율은 0.89[0.60; 1.31]이었다(p-값 0.55). 따라서, 이 부분모집단에서 마시티닙 치료의 유익한 또는 해로운 효과에 대하여, 유전자 발현에 따른 추가적 분석 없이는 어떠한 결론도 내릴 수 없었다.

적어도 한개의 유전자 발현 예측변수 인자를 지닌 것으로 알려진 부분모집단(이하, "유전자 지문" 또는 "전사 지문" 부분모집단(66명의 환자)이라 함)에서 OS를 분석하였다. 반대로, 전자 발현 예측변수 인자를 전혀 나타내지 않는 환자는 이하에서 "비유전자 지문" 또는 "비전사 지문" 부분모집단(53명의 환자)이라 한다.

표 6은 치료군에 따른 '유전자 지문' 부분모집단에 대하여 일변량 및 다변량 분석을 통해 산출된 중앙 OS 및 생존율 추정치를 나타낸다.

일변량 모델에서, 마시티닙 플러스 겜시타빈 치료군의 환자는 중앙 OS가 11.7 개월인 반면, 위약 플러스 겜시타빈 치료군의 환자는 5.3 개월이었다.

다변량 모델에서는 중앙 OS가 각각 12.9 대 4.7 개월로서 차이가 더욱 두드러졌다. 베이스라인 특징에서의 차이를 조정한 후, 중앙 OS의 차이는, 사망 위험 비율(위약 플러스 겜시타빈에서의 사망 확률을 포과하는 마시티닙 플러스 겜시타빈에서의 사망 확률로 정의됨)이 0.22 으로서(95% 신뢰구간 [0.12;0.40]), 통계학적으로 유의함(p-값 <0.00001)이 증명되었다. 따라서, '유전자 지문' 부분모집단에서 환자는 겜시타빈 단독인 것과 비교하여 마시티닙 플러스 겜시타빈으로 치료할 경우 사망 위험이78% 감소하였다. 더 큰 신뢰구간 범위(즉, 0.40)의 최악의 시나리오에서, '유전자 지문' 부분모집단에서 환자의 사망 위험은 마시티닙 플러스 겜시타빈으로 치료할 경우 여전히 60%까지 감소하였다. '유전자 지문'을 보이는 환자에 대한 Kaplan-Meier 추정치를 도 7에 나타내었다. 위약 플러스 겜시타빈을 뛰어 넘는 마시티닙 플러스 겜시타빈의 치료적 이점은 다변량 모델에서 명확히 확인할 수 있는데, 여기서 마시티닙 플러스 겜시타빈 생존 확률은 지속적으로 더 높다.

표 7은 추정된 중앙 OS 및 '비유전자 지문' 부분모집단의 생존율을 나타낸다. '유전자 지문'을 보이지 않는 환자에 대한 Kaplan-Meier 추정치는 도 8에 나타내었다.

일변량 모델에서, 마시티닙 플러스 겜시타빈 치료군의 환자는 중앙 OS가 4.8 개월인 반면, 위약 플러스 겜시타빈을 받은 환자는 14.4 개월이었다.

다변량 모델에서는 중앙 OS가 각각 5.6 및 13.2 개월이었다. 중앙 OS의 차이는, 사망 위험 비율(위약 플러스 겜시타빈에서의 사망 확률을 포과하는 마시티닙 플러스 겜시타빈에서의 사망 확률로 정의됨)이 4.24로서(95% 신뢰구간 [2.11;8.52]), 통계학적으로 유의하였다(p-값 = 0.00001). 따라서, '유전자 지문' 부분모집단에 속하지 않는 환자, 즉, 적어도 한개의 유전자 발현 예측변수 인자를 지니지 않은 환자는 겜시타빈 단독인 것과 비교하여 마시티닙 플러스 겜시타빈으로 치료할 경우 사망 위험이 더 높았다. 따라서, 다른 긍정적인 예측변수 인자가 없는 경우, '비유전자 지문' 부분모집단에서 환자의 상기 치료는 권장하지 않는다.

마지막으로, 환자 집합내에서 게놈 데이터와 베이스라인 VAS 통증 강도 상태, 즉 통증 강도 예측변수 인자 간에 어떠한 상관관계도 없음을 알게 되었다. 이는 전체 게놈 집단(전체 모집단), 뿐만 아니라 '유전자 지문' 및 '비유전자 지문' 부분모집단에서도 사실이다. 본 발명에 있어서, 이론에 의하여 제한되지 않기를 바라는바, 이는 통계학적으로 구별할 수 있도록 더 큰 모집단 샘플 크기를 요구하는 매개변수 때문이거나, 아니면 통증 강도의 예측변수 인자 및 유전자 발현이 질병 진행의 서로 독립적인 메카니즘을 통해 활동하기 때문인 것으로 보인다. 후자의 경우, 주어진 환자가 어떤 예측변수 인자에 대해서는 긍정적이지만 다른 예측변수 인자에 대해서는 부정적일 가능성이 높으며, 마시티닙 치료는 여전히 치료적으로 유익할 가능성이 높다; 명백한 모순이 없다.

따라서, 약 55.5%의 환자에 해당하는 '유전자 지문' 부분모집단에서, 위약 플러스 겜시타빈에서 중앙 OS는 4.7 개월인 반면, '비유전자 지문' 부분모집단에서는13.2 개월이었다. 따라서, 현재까지 베이스라인에서 '유전자 지문'으로 정의된 환자는, 겜시타빈 단독치료의 췌장암 표준 치료를 받을 경우, 전체 생존율에 있어 최악의 예후를 보이며, 따라서 의료적 필요를 가장 충족하지 못한다. 마시티닙 플러스 겜시타빈 치료는 '유전자 지문' 부분모집단에서 유의하게 전체 생존율을 개선하였다: 중앙 OS 는, 위약 플러스 겜시타빈에서 4.7 개월인 것과 비교하여, 12.9 개월이었다(p-값 = 0.00000056). 12, 18 및 24 개월에서 전체 생존율은 마시티닙 플러스 겜시타빈을 받은 환자에서 각각 52.5%, 18.3%, 및 12.6%인 반면에, 위약 플러스 겜시타빈으로 치료받은 환자에서는 7.4%, 0.8%, 및 0.3%이었다. 위험 비율은 0.17이었고(95% CI [0.09;0.33]), 이는 위약 플러스 겜시타빈 치료군과 비교하여 마시티닙 플러스 겜시타빈을 받은 환자의 경우, 사망 위험이 83%까지 감소하였음을 제시하는 것이다.

결론적으로, 상기 정의된 통증 강도 및 유전자 발현 예측변수 인자는, 암환자, 특히 인간 췌장암 환자에서 전체 생존율이 낮은 경우에 있어 서로 독립적인 것으로 나타났으며, 상기 정의된 '통증' 및 '유전자 지문'의 환자 부분모집단에서 의료적 필요를 가장 충족시키지 못함을 강조한다. 이들 두 예측변수 인자는, 선택적으로 적어도 한가지 항종양제를 조합하여, 적어도 한가지 티로신 키나제 저해제, 비만세포 저해제 또는 c-Kit 저해제, 특히 마시티닙 또는 약학적으로 허용가능한 그의 염의 조합으로 치료하는 것에 적합한 환자를 밝혀낸다.

SEQUENCE LISTING <110> AB SCIENCE MOUSSY, ALAIN KINET, JEAN-PIERRE PIQUEMAL, DAVID <120> USE OF MASITINIB FOR TREATMENT OF CANCER IN PATIENT SUBPOPULATIONS IDENTIFIED USING PREDICTOR FACTORS <130> CDM-427/PCT <150> EP12306214.3 <151> 2012-10-04 <160> 55 <170> PatentIn version 3.5 <210> 1 <211> 19 <212> DNA <213> artificial sequence <220> <223> probe <400> 1 atggggaagg tgaaggtcg 19 <210> 2 <211> 22 <212> DNA <213> artificial sequence <220> <223> probe <400> 2 ggggtcattg atggcaacaa ta 22 <210> 3 <211> 23 <212> DNA <213> artificial sequence <220> <223> probe <400> 3 gctcagtaaa gacacaacca tcc 23 <210> 4 <211> 21 <212> DNA <213> artificial sequence <220> <223> probe <400> 4 catctgtgga ttcagcaaac c 21 <210> 5 <211> 19 <212> DNA <213> artificial sequence <220> <223> probe <400> 5 ccagtgggga tcggacaga 19 <210> 6 <211> 23 <212> DNA <213> artificial sequence <220> <223> probe <400> 6 aggggatcat cgaagaggta aat 23 <210> 7 <211> 20 <212> DNA <213> artificial sequence <220> <223> probe <400> 7 tttcttcact gcagggcttt 20 <210> 8 <211> 20 <212> DNA <213> artificial sequence <220> <223> probe <400> 8 ggaaaggagg gattttgagc 20 <210> 9 <211> 20 <212> DNA <213> artificial sequence <220> <223> probe <400> 9 ttttgctctt tgtggttgga 20 <210> 10 <211> 21 <212> DNA <213> artificial seuqence <220> <223> probe <400> 10 cctggtccac agaagatgtt t 21 <210> 11 <211> 22 <212> DNA <213> artificial sequence <220> <223> probe <400> 11 ggacataaca gacttggaag ca 22 <210> 12 <211> 24 <212> DNA <213> artificial sequence <220> <223> probe <400> 12 tggcaatttc ttacactaac ctga 24 <210> 13 <211> 25 <212> DNA <213> artificial sequence <220> <223> probe <400> 13 ggtttcatat ttaatttggt catgg 25 <210> 14 <211> 23 <212> DNA <213> artificial sequence <220> <223> probe <400> 14 caaacaagga agcacattgt gta 23 <210> 15 <211> 20 <212> DNA <213> artificial sequence <220> <223> probe <400> 15 gatttggtcg caaaggtcat 20 <210> 16 <211> 20 <212> DNA <213> artificial sequence <220> <223> probe <400> 16 tgcctttgta tagggccaaa 20 <210> 17 <211> 21 <212> DNA <213> artificial sequence <220> <223> probe <400> 17 ggaggacatt tggtgggctt t 21 <210> 18 <211> 20 <212> DNA <213> artificial sequence <220> <223> probe <400> 18 ccctctgagc actggaagtc 20 <210> 19 <211> 22 <212> DNA <213> artificial sequence <220> <223> probe <400> 19 atccaacgtc caataaacag ca 22 <210> 20 <211> 21 <212> DNA <213> artificial sequence <220> <223> probe <400> 20 aaggctacca caatgtctcc t 21 <210> 21 <211> 22 <212> DNA <213> artificial sequence <220> <223> probe <400> 21 gggaaaggaa tctactttgc tg 22 <210> 22 <211> 20 <212> DNA <213> artificial sequence <220> <223> probe <400> 22 ttctttaggc gagaggcaaa 20 <210> 23 <211> 20 <212> DNA <213> artificial sequence <220> <223> probe <400> 23 cgcaggtttt ccactcatct 20 <210> 24 <211> 19 <212> DNA <213> artificial sequence <220> <223> probe <400> 24 atggccattt cttcccaag 19 <210> 25 <211> 44857 <212> DNA <213> homo sapiens <400> 25 acagatttgg aaagccgacc attatttctt cagaacaagg aacacattgt acagcccata 60 atggccaaca atgagcaaaa agatctcctc ctcagagtca tagtttgata gagaagtaag 120 atgtcctttg caaaaattgt atcagtgaga gaattaggac agcgggggag agctgatcta 180 gccagtcccc ctcttgcctt tggcctctaa gctgccctta attattcctg gatttgggcc 240 aagctaactt tgggagacat ttagtttaca gtttaaatga aaatagccct tccctaaaac 300 gcagccacct ttgtaaagct aatgagaaac caccaggcta ggagcacaga gaagcccgaa 360 ctctgctaag attgccagcc attattccag gggtcacaag ctaggcaact tccccagtta 420 ctcctgcaga taacatcact attgcagaac ctaagattgg cctttggaga tatcttttca 480 ggttttttgc atgtctgaca ccaacaactc cacatggacc ccacccacca ctcctgcggc 540 ccccctcaga ggtgactcag cctgcaggag gaccatttgc cacaccccta aggttgcacc 600 cccaaccaat cagcagcaag cacccattgc ctagctgcca ccaccccttc cccgaaacta 660 catttaaata atgtctaatc tctgagcctt ccagaagatt gactaataat accaactccc 720 acgtggtgtg gccagccttg tgtcaattag tctttcttga ctgtaatgcc atgctctcca 780 tgaaatgatt tcgtttgtgc tgtgggaacc catcaggtgg ttatagaggt ggcataggct 840 atgaaaacac tggttgtcta aaacaggggg agataacaat tatgaagggc tagtgtacac 900 gagtgtgtgc tcactaacat gaggggacta aaggagtgtc cccactagat gttcctgttt 960 ttctggtgga tctggggaaa aagaggtggg gaggatgctg gggttgctat gcaattctca 1020 ccgagggagg aatttgctgg tataatgatt atacattttt ctttctttct ttctttcttt 1080 tttgagatgg agtctcgctc tgtctgccag gctggagtgc agtggcggga tctcggctca 1140 ctgtaaccac tgcctcccgg gttcaagcga ttttcctgcc tcagcctcct gagtagctgg 1200 gaatacaggc gtgtgccacc atgcccggct aatttttgta tttttagtag agacggggtt 1260 tcaccatgtt ggccaggctg gtcatgaact tctgacctca ggtgatccac ccacctcggc 1320 ctcccagagt gttgggacta caggcgtgag acacctcacc gggcctcttc cttttttctt 1380 tctttttttt ttttttgagc caaggcgggc agatcacttg aggtcaggag ttcgagacta 1440 gcctggccaa tgtggtgaca ccccgtctct actaaaaata caaaaattag ccaggcatga 1500 tggcgggtgc ctgtaatccc agctacaggg aaggctaagg cagcagaatt gcttgaaccc 1560 gggaggcgga ggctgcagtg agccgagatc atgccactgc actccagcct gggcgacaga 1620 gtgagactct gcctgaaaaa ataataaata aataaataaa taaaactatg atcaatgctt 1680 gagcctaaga gtttgaggct gcagtgaact atggttgcgc cactgcattc tagtctgggt 1740 gacagagcaa ggccttgtct caaacaaaac aaaacaaagc aaaactatga tcaaatacat 1800 gtgtatgcct tttctcctat taatcacttg tgtggtattc ctgccaaaaa tgcatcatct 1860 gaatctaatc atgaagaaat atcagacaaa tctgaattaa gggacattct actgtaggtg 1920 ccaaggggcc ctctgaagtt tcgctgcaaa aaatcaactt acaaaaggca gagtaatagt 1980 caaaaatgtg tacaaattta tgtaacatgt acatatggga gccttcagaa ggaagaccca 2040 aagatacagg ggaaattgta catttttatg caaatgattg aacataaaag gtatgatcta 2100 atgctgatag actgagtggg gaggcccagc aaggcctgtc tgtctagatt cttcttggcc 2160 tcttggaaca ggcattcctt ccttctgggt gtgggggagg accctctctg gaatggagtc 2220 ttatggccta cagtcaaaca agctaggtca gataatttct ttttggccag tttttacacc 2280 aaaagaagga gggaaagtta agagtaatat atttagggtt ttttttgttt gttttttgag 2340 acagagtctc actctgtcgc ccaggctgga atgcagtggt gcaatctcgg ctcactgcaa 2400 cctctgcctc cccggttcaa gcgattctcc tgcctcagac tcccgagtag ccgggactac 2460 aggcacatgg cacctcgctc ggcttttttt gtatttttag tagagacggg gtttcaccgt 2520 gttagccagg atggtctcga tctcctgacc tcgctatcca cctgccttgg cctcccaaag 2580 tgccaggatt ataggcgtga gccaccgcac ccagcttata tttagggttt tatggctggc 2640 tttgggggta aatgactctg ttttctatga cctgccttgg ggaagaggat tctaacttct 2700 ctggctaggc tcgggggaga atgcacctga gggagaggag gacagaaggt aaaaaaaaaa 2760 aaaaaaacaa cttgctttgt gggttgcttc tgaggccttc attttggggt attgttttct 2820 gagacccaac actacaaaac aatgggctta tacacttcaa aagtgttaat gtcagccagc 2880 caggcgcagt ggctcacgcc tgtaatctca gcactttgga aggctgaggc gagcggatca 2940 catgaggcca ggagttggag accagcctgg tcaacatagt gaaaccctgc ctctaataaa 3000 gacacaaaaa ttagccaagt gtggtagtac attcctgtag tcccagctac tctggaggct 3060 gaggcatgag aatcatttga acccaggagg cggaggttgc agtgagctga aatcatgcaa 3120 ctgcactcca gcctgggtga cagaggaaga catcatctca aaagaaaaaa aaaaagcgtt 3180 aaagtcacag aagaaaagtt ctttgttcta ttcttgtaat tctcgtgtaa atttgaaatt 3240 atttcaaaat aaaaactcag caaatttagc tcttcatcta agtcttttct attcaatgct 3300 aagtacaccc cttatcattg ttacattaag agcaattggt ttcctagaat attagaacta 3360 gaaggtcagc tgtcaagcag ccatttgttc actccacaaa gatttcctga gcacctttag 3420 cggggcaggc actgtgccag gtacagagaa taaactagac accctctctg ctgttgaagg 3480 ggcctgagat cagcagctta ataagacaaa tgaggatcct gaggtcctag gggttaagag 3540 tgtgtattat agttctatta ttcaaattat gaatgttatg catctctcgt agttttactt 3600 ctgagaaaac caaagtcata gtattacaca gactacagac aggctaggcg cagcggctca 3660 cgcctgtaat cccggcgctt tgggaggccg aggcaggtgg atcaacaggt caggaattcg 3720 agaccagcct ggccaacatg gcaaaatcct gtctctacta aaaatacaat tagctgggtg 3780 tggtggcgag cccctataat cccagctact cgggaggctg agataggaga atcgcttgaa 3840 cccagggggt ggaggttgca atgagctgag atcataccac cacactgcag cctgggcgac 3900 agagcgagac tccgtctcaa gaaaaaaaaa aaaaatgact agagatgatt caacaaatcc 3960 ctgaatctcc cttgtctaca atcccactgg gcagaactgt ttttgttttt tgtttttttt 4020 ctgtagagac agggtctcac tatgttgccc aggatggagt gcaatgtcac aatcttggct 4080 caccgcaacc tccacctccg gggctcaagc caccatccca tctcagcctt cagagtagct 4140 gggactacag gcgcatgcca ctacacccag ctaatttttt ggtatttttt gtagggatgg 4200 ggttttgcca tgttgcccag gctggtcttg aactcctggg ctcaagtgat acgcccgcct 4260 cgtcctccca aagtgctggg attccaggcg tgagccaccg cgcccggccc tacactaggt 4320 tttaacagta agtgtgcatt tcccactttg atgacggtga tggcgaaagc aaagaagtct 4380 ggattccaag acctctagta actgccaggt tgcgggggaa aatgtctggt ttcccagaca 4440 gaaggcttag agcagcaccg cccgcttggt ctcattctaa gtccccgtcc accccttgaa 4500 cagcgctcac aatcccacac ccagggcccc ggaacccacg cctctgccag taaagacgcc 4560 attatcttaa caaaaggtaa ctggagcctc tccccaaaga gactggttcc cgtcccattc 4620 ttctccaatc cgggtggatt tggcaaaagc ccaagtgacc ctccctagca attccgcaaa 4680 gccccatctc ccgccccaga ctccagagtc tcccgaccac tctcatttcg gagaggccta 4740 ggggcacgga cccggaagcg tgacagaggc cgcggggtaa gaggggggca agtgcaggcg 4800 caatccctcc tcagcctcgt tgtcccgccc ccttcccaag gccccagcca acctgttcta 4860 ggcgtcgccg gtcctcggat ttcttctttc cgcctcgcgt ggtcacgtga cgggggaggg 4920 gcgggataca aaaagtgctt tattttccca ctccccggac gcccagcagg gcagtttctt 4980 gaccttcgga gcccctttcc cgaggatccg ctcgggagcc tcccctggcc aggagcaggg 5040 gattagtctg ccccgcgacc ggccccagcc acgacgcgga catcgccccc tctgtctggg 5100 ccgctgtcac tcacgcgcca aagggccacg gagaaagaag gggcgggccg gggcgggccg 5160 ggcgagcgga ggcggggact tgcgccgtcc tgaggctgcc tcctagggtc cggccggcgc 5220 tggagctgcg gatttagatt gtcactgcca cctcggtcgg tgcttacttc gctgccagct 5280 ggtcgtcgcc atgaacccgg acctgcgcag ggagcgggat tccgccagct tcaacccgga 5340 gctgcttaca cacatcctgg acggcagccc cgagaaaacc cggcgccgcc gagagatcgg 5400 tgagggcggc gggcgagacc tccctccttt cccgagaaaa gctggagact ccctcgatgc 5460 ggagtcaggg gcgctgtggg gcctaggccc tctggcccag cgttagggga gccgggaccc 5520 ccacttcgag gaacagcctg tgtccctggt ggggggatat cgccattccc caggtgtgtc 5580 cgcgactctg aagcctattg tgattcaggg agggtggaac ggaggcccga gtgtctgtct 5640 gccttttaat gccctttaac cccctttcag agaacatgat cctgaacgac ccagacttcc 5700 agcatgagga cttgaacttc ctcactcgca gccagcgtta tgaggtggct gtcaggaaaa 5760 gtgccatcat ggtgaagaag atgagggagt ttggcatcgc tgaccctgat gaaattatgt 5820 ggtttaaaaa gtaggtatgc cttagaacag agcaagtgtt gttaagccta aactttacag 5880 ctgcggtcta tggtggcctt tcatcaccgt gcttggtgtt tgaagatgca aactggcata 5940 ttttcatgca actttataaa gttatatgtg tggccgggcg cggtggctca cgcctgtaat 6000 cccagcactt tgggaggccg aggcgggcgg atcaccaagt caggagatcg agaccattct 6060 ggctaacacg gtgaaacccc atctctactg aaaatacaaa aattagccgg gcgtggtggc 6120 gggcgcctgt agttccagct actcgggagg ctgaggcagg agaatagcgt gaactaggga 6180 ggcggagctt gcagtgagcc gagatcgcgc cactgcactc cagcctgggc aagagtgcga 6240 gactccatct caaaaaataa ataaataaat aaataaataa agttatatgt gtgaaaaata 6300 atgtgatcac ttttgtatcc aagccttttc gtgggatgac gtgtttgtag aatgctgata 6360 ataaatggaa atgcaggagt ttttgttctc aagagtacag tttcaaggat gttgtaaaag 6420 cattgttctg cccaagcaac tcaaatttga ctgatttaaa tgcagaatca ttttgctctt 6480 tgtaaggagg actgctaaaa ttctgaatct gggagcattt ttttttttag ttgcacgacc 6540 atttaaatat tttggagcaa tagcagatta tattatatgg tagtgtggac ctggatgaag 6600 aatgatctgt gacgcctctg aatgaataga aagtctaaga acccagtagt tctgaatcca 6660 tgacagtgct tgaatggttg tcttgtgcat atgagagaga cgtcataaaa acctgccttg 6720 gttctagtgt ggaagagagt atatcctttt ttcagaccat gtgttttgtt gtgttttttg 6780 tttttgtttt tgttttttga gacggagtct cgctctgtcg cccaggctgc agtgcagtgg 6840 cacgatctcg gctcactcca gcctccacct cccggattca agcgattctc ctgcttcagc 6900 ctcctgagta gctgggatta caggcgcccg ccaccacacc cggctaattt ttgtattttt 6960 agtagagatg gggtttcgcc atgttgccag gctggtctca aactcctcac ctcgtgatcc 7020 accctgctcc acaaggaacg gtaaaaataa ataaaaataa ggacttcggg ccgggcacag 7080 tggctcatgc ctgtaatctc agcactttgg gaagccaagg caggtggatc acttgaggcc 7140 aggagctcga gaccagcctg gccaaaatgg tgaaactctc tctactaaaa atacaaaaat 7200 tagccgggcc tggtggtgcg cttctggggt cccagctatt caggaggctg aggcaggaga 7260 atcccttgaa cctgggaggc aaaggctgca ctgagccgag atcacgccac tgcactccag 7320 actgggcaac aaagagagac tctgtctcaa aaaaaaaaaa aaaaaaaaaa aagacttttt 7380 tgccttaacc taaacaaaca ctattacatg atcctagtac aagattattt tggcctatag 7440 catttttttc tcatttattc ctgggcattt tctcttttag gtttctccat tttaaaggaa 7500 ctccagtatt ttcatcggta aagactaaat cgtatgagtg gtgtatagac tagaaccaag 7560 ctaaatagaa catgttgcac gttctgcctt tatggtaata atggtcactg cctctagtgc 7620 ctttggtatc gattttcagc ttgacttggg ttatttttgt gaagatgaaa tggtttactc 7680 tggcactttg gactttcctc agagctccac tcagttttaa acgaaaaaat tttgtttatt 7740 tatttttggt agttcaaatc agcatacttc caaatggtct gttttgtttt tgaagtttgt 7800 aactcatggc tgtggggata ttgagataga gtaactcctc ctagaagatt atgttactga 7860 tacctgtgtt gtgtttgtaa atttgaaaaa attagtaaga ttttattcct tcttgaaacg 7920 tcaggaaaaa agtgggttga gtgtgtgtgt gtgtgtttga atgggtggtg cagtgcattt 7980 caaagctgat agagatgatt tcataacctg tgacctgttg ataatgtgaa ccagactcga 8040 gtgaggtcac aatgaaatag aacaaagtct tttatgcggg ttaaagattc atggacaccg 8100 ggaagttgtt ttgtgtatca tttttcatgt gaagtattaa agtacaaact ttaacacacc 8160 ctttgacaca cttccaatgt ccttaggata tgacaaggag atcagttttt aagtaagaga 8220 aggggtttgt aaatgagtcc tggaaattat cgcatgctat cgagttaaag cctcggttat 8280 ataatctcat cgattataac tcacaccagt gttttgtgta ccactaagaa agaaagaatg 8340 ctgccagtta accgtgacat gctattaatt gtgaaataca tcacctttct ttcttttctt 8400 ttctttcttt ctttcttttc ttttctttct tttcctttct ttttctttct ctttctcttc 8460 ctctttcttt ttctttctct ctctttcttt ctctctctct ctctctctct gcatttccat 8520 ttatttccat tatcagcagg tgaagaggca tctgccacct cacccagcta acttttgtat 8580 ttttagtaga aatggggttt caccatgttg gccaggctgg tctcgaactc ctggccttgt 8640 gatccacccg ccccttcctc ccaaaatgct gggattacag gcataagcca ctgcgcctgg 8700 ctgagaaaac atttttaact gatgttaatg agcagcttct aaacacatga ttaggacgca 8760 gaagtcgttc cctctggtgg aatctataat gattacatta attcattttg attaattaga 8820 aatattcgta tctaagagca tccatgttga gagttttttg tttctaagtg gattatgatt 8880 tatgtaagat agaaaagaca atgggactgg ggcatggtgg ctcacgcctg taatcccagc 8940 actttgggtg gctgaggtgg gcagatcact tgaggccagg ccacttcatg accagcctgg 9000 ccaacatggc aaaacgcctt ctctactaaa atacaaaatt aaccgggctt ggtggcacac 9060 gcctataatc ccagctactt gggaggctga ggcatgagaa tcacttgaac ctaggaggca 9120 gaggttgccg tgagctggga tcacaccact gtactccagc ctgggcaaca gagggagact 9180 gtctccaaaa aagaaaaaaa aagaaatggc ggggataacc gtgtagtact tatttaggaa 9240 atagaaaaat aagggtatat tgtgtttact attatttctt tctttctttc tttttttttt 9300 tttttttttt tttggagaca gagtctcgct ctgtcgccca ggctggagtg cagtggtgcg 9360 atctcggctc actacaagct ccgcctcccg ggttcacgcc attctcccgc ctcagcctcc 9420 tgagtagctg ggactacagg agcccaccac cacacccggc taattttttt tttgtatttt 9480 tcgtagagac ggggtttcac catgttagcc aggatggtct cgatctgatg gtctcgatct 9540 cctgacctcg tgatccaccc gccttggcct cccaacgtgc tgggattaca ggcgtgagcc 9600 accgcgcccg gctactatta tttcttttaa ggtggtagtt tggtttcagg gtcccccagc 9660 actgcaatgg cagcctatcc cttctgtcct ttagttcatg ctctgctcat tgcacaggtt 9720 aggataaact ggtagtaaca ttgcttccta atcatgtgtt gagaagtcgt gaagatcagt 9780 tagatgagat gtattttgta ctttaaactt tttagatacg agctttgtca aagtacaaaa 9840 ttgatcccta taaaatctat gacacagcac agccaaggcc aactactgtg gattctgttt 9900 tgtaagaaga gagttgagga ctaaatttca atgtgatgta gagttaatcc gtagtaatgt 9960 tcattgacca ttggggataa atttttacat gcccacatta cttattgtaa accctgaaga 10020 cctttagcga tgtatgattc tgccctggaa tatgtattta ctcttttgga tatttgctta 10080 tattatctag ggaaacatag ttgaaattat ttcttccttg gagctcttgt taacagcgct 10140 ataaataagt gttctatgga gttatttttg ctctttgaaa caaacaggta aaacctaaat 10200 aaagcaaaaa aaaaaaacca cacacattct aaaaaattca accaatcaaa ccagcaaata 10260 acaccaacaa cctccccttc caaaaattag agaagttttt atgctaaaac ttaggtagaa 10320 tttgcttagt ggattaaatg taaatacgaa atgaactgtg ggaactgtgg ccttgaaata 10380 attagaagaa gagagatcat caggttctgc tgctggcttt ttaggtagta aaatggtaaa 10440 tcttatattt aatttcataa gaagggggtt tacattttcc tgaccttctc cttgaaggcc 10500 aaagctgttt ggcaagaagg ggttgtagga tgcagtttct aaaggaaggc tgagatcctt 10560 ttctcttctc tcctgtagac tacatttggt caattttgtg gaacctgtgg gcctcaatta 10620 ctccatgttt attcctacct tgctgaatca gggcaccact gctcagaaag agaaatggct 10680 gctttcatcc aaaggactcc agataattgg cacctacgcc cagacggaaa tgggccacgg 10740 ttagtccaca ttgagggtct gtgggtaacc cacctcagga catcagttaa cagtgattgc 10800 tggcatttga cttttttctg ctgctacctg tttgggattc tatttttaag ttgttaagtc 10860 aaaattcaac ttcttgtttt ctcctagaca ttttccctgg aaactggtcc agggctctgg 10920 cctataaacg tcattcactg ttatttccta aagcctttta ttattgaaca gcttgaaaag 10980 atggggttta cagtgcagcg gggaacccca ttatgttact ctgggtctaa tgagtaaaga 11040 ctttgttgga aattcttcag agggttagtg cctcagcaat atctggaaag cgcctctctg 11100 ctctaatgca gttaaagctg tggattttaa tgggggcagc aggcagtggc agctacctgt 11160 ctcatctcat tgcccactag cagggttata aggcagtttg gaaaaaagtc catgattctc 11220 ttcatctgac ttcagtcttt ttagacattt tttcccctac atgtctggga actcttgtgt 11280 tgccagtaat tctttgttaa attgttccta aatatctggc ttccttcaaa aagttttgct 11340 tttgatctta atgtgaaata ggtttgtttt catagacaag gccattggca ggtttgagtg 11400 tttggaattt gaactgccca gcctcatgtc taattatcaa aatggcagga gtaaagaaag 11460 ggaaagaaaa agggatgcag atatcaggga aacatcattt tgtgtttgat tgctgatttc 11520 agtgtgtgaa ttggtttaag gaaaatgtta tttattgtca tctccatggg tactgcagct 11580 ttctggtcat ggtttgatgt tccagacact ttactaaaca ctcaagactt caacttcaag 11640 atggtcagta ctgaaattat aagcctgaaa gaaaggtttg taaaggaaga taagattctt 11700 tttttttttt ttttttttga gacagagttt tgcttttttt gcccaggctg gagtgcaatg 11760 gcatgatctc agctcactgc aacctccgcc tctgggttca agtgactctc ctgcccgagc 11820 ctcccgagta gctggaatta caggtgctca ccaccacgcc cggctgattt tgtattttta 11880 gtagagacgt ggtttctcca tgttggccag gctggtcttt aactcctgac ctcaggtgat 11940 ctgtccacct tggcttccca aagtgctggg attacaggct acaggcgtga gccaccgcgc 12000 ctggctgaca gatccttcct tttttttttt ttttttggag acagagtctc actctgtcgc 12060 ccaggctgga gtgcagttgt gccatctcgg ctcggtgcaa gctccgcctc ctgggttcac 12120 gccattctcc tgcctcagct cctcagtagc tgggactaca ggtgcccgcc accacgcccg 12180 gctaattttt tgtattttag tagagacggg gtttcaccgt gtaagccagg atggtcttga 12240 tctcctgacc tcgtgatctg ccctcccaaa gtcctgggat tacaaggcat gagccactgc 12300 acccggcctg agagataaga ttctttatgt agtcctcctc gcttggagta tctgtgtgtt 12360 tgtgtacatg catgcgtggt gtgtgtgtgt gttgtaattt tgaagtagct ttgtggtaca 12420 gaactctgtt tcagtattca tcattataga atttattcga cttaacagtc atgctgttca 12480 taggaggcat aagatgtgaa atagtctgag gctaatggat ttgttaagta tacctcttac 12540 ctcttgttgg tctaatgctt ctgcctcatt tataaagtaa tatcacaaat atatatttgc 12600 cctaattttt tttttttttt ttgagtcaga gtctcatcct gtgccccagg ctgaagtgca 12660 gtggagtgat ctcagctcac tgcaacctcc acctcctggg ttcaagggat tctcctgcct 12720 cagcctcctg agtagctggg attacaggca cctgccacca tgcccggcta attttgttat 12780 ttttagtaga gatggggttt ggccattttg gccaggctgg tctcaaactc cttacctcag 12840 gtgatccacc tgtctcagcc tcccaaagtg ctgggattac aggtgtgagt caccacgccc 12900 ggcctgccct aatttttgaa aggagagagg aagaaaggaa gacttgaact atactggttt 12960 gaggcaaaca gaagttggac agagatccta tatggctgtg ggcaagtttg catttgttag 13020 agttttcgtt cccttattgc ttttagtttt gggtattttt tttttttttt ttgagacaga 13080 gttttgctct tgttgcccag gctggagtgc aatggcgcga tctcggctcc ccgcaacctc 13140 cgcctcccag gttcaagtga ttctcctgcc tctccctccc tagtagctgg gattagaggc 13200 gtgtgccacc atgcccggct aattttgtat tttcagtaga gacggggttt ctccatgttg 13260 gtcaggctgg tctcgaactc ccgaccttag gtgatctgcc cgcctcggcc tcccaaagtg 13320 ctgggattat aggcgtgagc catcatgccc agctagtttt gggtattttc ttgtatttaa 13380 accaacgttg tcttaatctc tgtggtttag agaacagtgt cctaagatta gtcttttttc 13440 ttgctggaat tttgctaatt catattgctg ttcttggttg atgactgatc ttttccttgg 13500 aaataagtca ggttggttaa tttgcatcac gtgacggttt tatcttatat ggaatacaca 13560 aaaagtcaac gtccaggaga tcggcaatag agcagcttat atagaatgag atctaactat 13620 ttaaattctg agactttgga aaatggatca acagtgaaca gtgattatct aacgcggtct 13680 cacagaagta gctgtaactt tgggtttggg attctttcac ttctgggtag ctgctgagaa 13740 gtgaaggggc tcagaagtat tcaggttcac tccatgttcc ttccaaatcc taaaattcag 13800 tcacctacag aaagtctcag tcaccagcat tatccttctt tctagagtgt gtcttctttc 13860 ctctaaggac acgaagaaac tcggatatac acctgccctg tgggtctggg agccataatc 13920 aaaggcagag gcctgaacct gggtgatagg ctcacctccc tggagttctg ggatcaaagg 13980 aacagcctgg ggaactgggt ccatgttatc atcctgacca tatgtttctt taggccacaa 14040 aacaggtcgt ttgtttgctc ttcacagata tgtaatcatt tcaagatgtg gccatttctg 14100 gagattcttc ttgctttgtt ttccttgttt gcttgcttgc tcacttcctt ccttccttcc 14160 tctttttttt tttttttttg aaggagtctc atgttgccca agctggagtg gtgcaatggt 14220 acaatctcgg ctcactgcaa cctccacctc cccctggttg aagtgattct cctgcctcag 14280 cctcctgagt agctgggatc acaggtgtgc accaccatac ctggctaata tttatatttt 14340 tagtagagac agggtttcac catgttggcc aggctggtct tgaactcctg acctcaggcg 14400 atctgcccac ctcggcctcc caaagtgctg ggattagaag tgtaagccac tgcacccggc 14460 ctctttctcg ctctctttct gtcttcttcc cttcctccat tcctttcgtt cctttctttc 14520 tttattcctc acccatggac tggggtcaca ttgccttgtt tcgtattacc atctatttag 14580 gaatatagag attgtatgat acatagttat ccttgaagct gatgcagtat cctggcaaat 14640 tgccatcatt aacacttaaa tatgaaataa tgcacctttc tttgaaactg gaaagaggta 14700 gtaaacttga tttttaagtc atcagtcttt accgcactcc gttgccctct ctccctaggc 14760 ttaacagtct cctcttccct ctgcccaagt gattctcttc cctgttggac ttctcatgag 14820 acttgcttcc ctggggattt gggctaaatt tcaccaatat tagtgataat aatataaact 14880 ttatgaaagc tgtgttctgg ccaggcacgg tggctcacgc ctgtaatccc agcactttgg 14940 gaggccagcg tgggtggatc acctgaggtc gggagttcga gaccagcctg accaacatgg 15000 agaaaccccg tccgtactaa aaatacaaaa ttacctgggt gtgatggtgc gtgcctgtaa 15060 tcccagctac tagggaggct gaggcaggag aagcttttga acctgggagg tggaagttgt 15120 ggtgagctga gattgcgcca ttgcgctcta gcctgggtaa caacagtgag actccgtctc 15180 aaaaaataaa taaataaata aataaataag acgctgtatt ctttggggtc atacttctgg 15240 aatacctctc agaaatgaat tactatattg agggacatga gcattttaga gcttttgctg 15300 catagtttga ggcttttcct gaaacacaga accagttgac aatatattga gcaagctctg 15360 tacctgtatt tccacagctc catcaacgtg gtcactttaa tttattttgc tactttaaca 15420 tatttctttt tttttttttt tgagacggag ttttgctctt gttgctcagg ctggagtgca 15480 gtggcgtgat ctcggctcac cgcaacttcc gcctcccgca ttcaagcgat tctcctccct 15540 cggcctcctg agtagctggg attacaggca tgcgccacca cgcccggcta cttttgtatt 15600 tttagtagag acggggtttc tccatgttgg tcaggctggt cttgaactcc tgacctcagg 15660 tgatccgccc gcttcagcct cccaaagtgc tgggattaca ggcatgagcc actgcacatg 15720 gcctacttta atatatttct tttttttttt ttttttttca ggcggagtct cgctttgtcg 15780 cccaggctgg agtgcagtgg catgatctcc gctcgctgca agctccgcct cctgggttca 15840 cgctattctc ctgcctcagc cccctgagta gctggtacta ctggcaccct ccaccatgcc 15900 cggctaactt tttttttttt ttttttttga gacggagtct cgctctgtcg cccaggctgg 15960 agtgcagtgg cgggatctcg gctcactgca agctccacct cccgggttca cgccattctc 16020 ctgcctcagc ctcccaagta gctgggacta caggcgcccg ccactacgcc cggctaattt 16080 tttgtatttt tagtagagac ggggtttcac cgttttagcc aggatggtct cgatctcctg 16140 acctcgtgat ccgcccgcct cggcctccca aagtgctggg attacaggcg tgagccactg 16200 cacttggcct actttaatat atttctaaca cttaatgttt taatttccca ttactagtaa 16260 gcctggatgt tattacgtgt tttgatttac tgtttgtgtt ttctatgtat aaaatacggt 16320 tttttggctg ggtgcaatgg ctctcgcctg taatcccagc actttgggag gccgaagtgg 16380 gtggatcact tgagatcagg agtttgagac cagtctggcc aacatggtga aacctgtctg 16440 tactaaaaat ctaaaaatta gctgggagtg gtggcggcac ctgtaattct agctactcgg 16500 aaggctgaag caggagaatc gcttgaacct gggaggtgga ggttgcagtg agccgagatc 16560 gtgccactgc actccagcct gggtgacaga gtgacatgct gtctcaaaaa atatatatat 16620 atatacgtgt atatatatat atgtgtatat atatatgtat atatatgtat gtatatatat 16680 acgtatatat atgtatatat atgtatgtat atatatacgt atatatatgt atgtatatat 16740 atatgtatgt atatatatat atatttcgat tttttaaatt attttctgct ttgctaaacg 16800 tttttgcttt atatatttaa cacatccttc tctgcatagg tataaatttt atcttttcca 16860 taacttggat agttttcttc tgggtttttt tttttgagac atagtcttcc tctgtcacca 16920 ggctggagtg cagtggcatc atcttggctc actgtaacct ctgcctcctg ggttcaaagc 16980 cattctcctg gctcagcctc ccgagtagct gggatcacag gtgcccacca ccacacccag 17040 ctaatttttg tatttttagt agagatgggg tttcaccatg ttggtcagga tggtctcgat 17100 ctcctgacct tgtgatccac ccgcctcggt ctcccaaagt gctaggatta caggcgtgag 17160 ccaccacgcc cggcctcttc tgttttcttc taatattttt gtttggtttc tgtttaatga 17220 tttgacttgt atatgataca gagtgagaat gaatctcatg gttttctaga tttttttttt 17280 ttgtacttct tttttctttt ttttgagaga caagagtctc actctgtcac ccaggctggg 17340 gtgcagtggc gcagcttccg agatttctaa tgttcattgt taactagtgg ctttttccca 17400 ttattatctt attcccatta tgtcctttct ggtttgtctt agagttttat aataggttaa 17460 atttatttct ggaaccttaa atatattaca ttgataggtt tatttctttc tttgtttttc 17520 ttctaacata aattttgacc actggtgctt tataaaattt ttttgagaca gaatctcgca 17580 ctgtcacctg ggctggagtg cagtggcgca gtcatggctc actgcaacct ctgcctcctg 17640 gattcaagcg attctacctc agcctcccca gtagctggaa ttacaggtgc ctgccaccac 17700 gcccagctaa ttttttgtat ttttagtaga gacgaggttt caccatgttg gccaggctgg 17760 tctcaaactc ctgacctcgt gattcaccca cctcggcctc ccagaatgct gggattacag 17820 gcgtgagcca ccgtgcccag ccaagacttt ttactctatt tttattttta ttttttattt 17880 ttttatttta attttttatt tatttttaag acggagtctt gctctgttgc ccaggctgga 17940 gtgcaatggt gtgatttcag ctgcctgcaa cctccgcctc ccgggttcaa gcgattctcc 18000 tgcctcagcc ccctgagtag ctgggattac aggcgtgcac caccatgctc agctaatgtt 18060 tatattttta gtagaaacgg agtttcacca tgttggtcag gctggtctca aactcctgac 18120 cccgtgatcc acccacctca gcctcccaaa gtgctgggat tacaggcacg agccaccgca 18180 cctggccttt attttttatt ttattatttt tatttattat tttttttctt tttcgagatg 18240 gagtcttgct ctgtcaccca gcctggagtg cagtggcatg atctcagctc cctgcaacct 18300 ctgcctccca ggttcaagca attcttctgc cttagcctcc cgagtagctg ggattacagg 18360 catgtgctac catgcccatc taatttttgt atttttagta gagatggggt ttcaccatgt 18420 tggccaggct ggtctcgaac tcttgacctc aggtgatctg cctgcctcag cctcccgaag 18480 tgctgggatt acaggagtga gccactgggc ctggcatatt tttatttttg aaagacgggt 18540 tcttgctctg ctgcccaggc tggagtgcag aggtttgatc atagctcact gcagccttga 18600 tctcctagac tgaagggatc ctcctgcctc agtctcccga gtagttgaga gtatgggctc 18660 gtgacaccgc gcccagttga ttttttaaat ttttagtaga gataggatct tgctgtgttg 18720 cccaggcttg taaggtattt aaaaatctga taggataagc ctactgttgt tacatttcaa 18780 gatacgtgta tttggtattt aagcttgctt attctagatg aattctgatc tgaatctgtc 18840 aggttctaaa aaaaaattct acaggaatta aatgtgtttt tctccttctc tatctggaat 18900 tttaagttag ttttatattg aagccttgtc ttttcttggg aagctatttc tttcctgtta 18960 tttttatctt tttttcccac cctattaggt atttatcttt tttctgggtt tttttttttt 19020 ttttttgaga cagagtctcg ctctgtcgcc caggctggag tgcagtgggg cgatctcggc 19080 tcactgccag ctccgcctcc tgggttcacg ccattctcct gcctcagcct cccgagtagc 19140 tgggactaca ggcgcccgcc accacacccg gctaattttc ttgtattttt agtagagatg 19200 gggtttcgcc gtgttagcca ggatggtctc aatctcctga cctcgtgatg cgccctcctc 19260 ggcctctcaa agtgctggta ttaacaggtg tgagccacca cgcctgagtg ctgttaattt 19320 tttttccctt atagcctgca gcttttctca attcacttat tgtggtattt tgttgacatt 19380 attgatttcc taggatgata ctcatgcttt ctacagagct gctttttatt tcttcctttc 19440 tcatatatga ttagtctaat tggtttttcc tcagtattga ttgtcagcct ttccagcctt 19500 gtatcatgtg gaaagagagg ctggggatgc cttttgatgt tttggtttta aaagagctga 19560 ctctagccct tcactaagta taatgttggt gcttcgtaat tttacgataa attatttaaa 19620 aataatatct ttatcatgca taagcagctt ttaaaacaaa tacttggctt aagtcaaaaa 19680 actatgcagt tcactttctc cttgtaacat ttctaaattt catccacatc tgaataatcc 19740 ttgtcttatt tggaagaaat atttttttcc tgaaaacatt ctttagtgtc agaaccattt 19800 gtgattatag tggttttacc cctgccctac tgagcgcatt tgttgtaacc cttagcgtgc 19860 atcttcactc tgtggtacac tcagatgtaa atcttccaga ggctgatggg tgcttgatag 19920 tggcctttcc ttcaccagga attgctctga tttctagtga agtaaaataa ccttccataa 19980 aagcatgaaa agtgtctggt cccaggtttc agtcctaact cagttttcac cttccaggtt 20040 ctaagtgcac attgaatttt cttcctagac agtactcaaa aggctgggga cagttgacat 20100 ttctgtttga gtgaaaggca ctctcatccc atgaatgtgt ttttcttggg atttccgcta 20160 ttaatttttt tttttttttt tttttgagat ggagtcttgt cccccaggct agaatgcagt 20220 ggtgcgatct tggctcactg caacctctgc ctcccaggtt caagcaattc tcgtgcctca 20280 ccctcctgag tagctgggat aaccagcgcc tgccaccatg cccagctaat ttttgtattt 20340 ttagtagaga tggggtttca ccatgttgcc caggctggtc tcgaactcct gacctcaagt 20400 gatccgccca ccttggcccc ccaaagtact gggattatag gcatgagcca ccgtgcctgg 20460 cctttttttt tttttaattt tgaaatgatt gtagagtcat aggaagttac aaaaatagta 20520 ccaggaaacc ctgtgaaccc gtcacggagt ctctaccagt ggtgacacct tgtgggattt 20580 ccatttttga ggcttctaag gacagccctg gctttttcag catgtctttt tagcatcttc 20640 attacagtca cagtcttttt ttttttttag atagagtctt gctctgttgc caggctggag 20700 ttcagtggca cgatctccgt tcactgcagc ctccgcctcc cgggttcaag gattcttcta 20760 ccccagcctc ccgagtagct gggattagag gctggcgctg ccacacctgg ctaatttttg 20820 tatttttagt agagaggggt ttcaccttgt tggccaggat ggtctcgatc tcctgatctc 20880 atgatccgcc caccttggcc tcccaaagtg ctgggattac aggtgtgagc caccgcgccc 20940 ggcctgcagt cacagtcttt agtccatgct atgcttgtgc agtaatttcc ccagctagga 21000 gacaggacga ggtgacaagg tggttctttt tttaaaaaat aggtttaggg ggtacaagtg 21060 ccatttcctt acatgtatat attatgtaat ggtgaagtct gggattttgc agtacccatt 21120 gcccaaatag tgaacatagt acccagtagg taacttttca ggcctcatac ccctcccatc 21180 cttccacatt ctggagcctc cagtgtctgt tttgttcgtt gttgtttttt gtttttcgag 21240 acagagtctc tgtcgcccag gctggagtgc agtggtgcca tcgtggctca ctgcaacctt 21300 tgcctcctgg gttcaagtga ttctcctgcc tcagcctccc aagtagctgg gattacaggt 21360 acccaccacc acgcccagct agtttttgta tttttagtag agatggggtt tcaccctgtt 21420 gaccaggctg gtcttgaact ccaacctcag gtgatccccc tgcctcggcc tcccaaagtg 21480 ctgggattac aggcgtgagc caccgcgcct ggcccctgtg tctgttactc cattctgcat 21540 gtccatgttt taccccttgc tcagctccca tggtgacgag attcttgtcc ttgttttgcc 21600 attttctttt ttccctgagc aaggcattta attcatctca gccttaattt ctcctctgta 21660 aaatgaggga ttcagtcaca catactttga tttttctttt tctaaagtgt gattgcttag 21720 ctgaaagcct agccactaga ttggaagaag tcattgatta gcacttgtct gagcagtgtg 21780 ccctggttct tttcctccct accttgcaag gaacaaacag caatttaaaa actgaactgt 21840 catttatgct catttcaaag acacatagaa tgataagagc aatatggagt tgacggattt 21900 ggagctggca attacacaga ataccagtaa tgtggaaaaa tgcaaaggcc tatagaacga 21960 cttcctatcc ctagcaaaaa ttcacacaga atcctgtccc ctgcacgttt taagtggaaa 22020 agaatgaccc cagaaagttg atttaaaact aataaagctg tttattatca ttaatgataa 22080 tttctgtata attgtcacgg agagcttatg catgaatctg taacttgtcg ttattatggt 22140 cttcactaga aattgcatgt cttttttaat ttctgaaata aattattggg atgaagagca 22200 ctgtcagttt ttgtattaaa gtgtttcagt agagcgtggc cgaatatttg acatgatgaa 22260 tctgaatgaa atgatcagag ctatgtgagg aatatggttc tacgctggat gttttgtgga 22320 caaaacagaa aaaaaatccc agcctagaag cattattgaa attgcatcga ggaaaaacta 22380 taatctgggg gtcatactgt cactctgaga gaactactat gttctgtctc gctttctcat 22440 cagaggaaat ccttgtacca gtaccactca aattctctgt tctccgactc ctggcttcaa 22500 gcgattctgc ctcagcatcc caagtagctg ggattacagg cacatgccac cacacccagc 22560 aaattctcca ttctatacaa cttttttttt tttttttttt ttttgagaca gagtctcgct 22620 ctgttgccca ggctggagtg cagtggtgtg atctcggctc actgcaacca ccgcctccca 22680 ggttctcctg cctcagtctc ccaagtagct tggattacag gcatgtgcca ccacacctgg 22740 ctgattttgt atatttagta gagatggggt ctcaccatgt tggtcaggct ggtcttgaac 22800 tcctgacctc aggtgatccg cccaccttgg cctctcaaag tgctgggatt acaggcatga 22860 gccacggtgc ccggcctttt tttttttttt ttttttttgt atttttagta gaaacgggat 22920 ttcactatgt tggccaggct ggtctcaaac tcctgacctc aagtgatccg cctgcgtcag 22980 cctcccaaag tgctaggatt acaggcatga gccaccatgc ctggccctat acaacttttc 23040 aaattctctc tctctttttt tttttttttt tgagatggag tctcactgtg tcgcccaggc 23100 tagaatgcag tggtgttatc ttagctcact gcaacctctg cctcctgggt tggagcaatt 23160 ctcctgcctc agcctcctga gtagctggga ttacaggtgt gcaccaccat gcctgcttaa 23220 tttttgtatt tttagtagag acagggtttc gccatgttgg ccaggctggt cttgaactcc 23280 tgacctcagg tgatccaccc acctcggcct ctcagagtgc tgagattata ggtgggagcc 23340 actgcacctg gccaattctc tcttatttat ttatttattt tttttgagac agagtctcac 23400 tctgtcaccc aggctggaat gcagtgggca tgatctcggc tcactgcaac ctccgcctcc 23460 taggttcaag cgattttcct gcctcaggct cccaaatagc tgggactact ggctggcgcc 23520 accacgttca gctgattttt gtatttttag tagagtcagg gctttgccat gttggccagg 23580 ctggtctcga actcctgact taaggtgatc tgaccgcctt ggcctcccaa agtgctgaga 23640 ttgtaggcat gatccactgc actggcctct caaattttct ttatttcctt tgatttaatt 23700 cctgggcgag gatcctctgc cttgcacgtg tggttttgtg ctgcattggc tttggaatca 23760 gtaaccaatc cctgtcctcg tactccttgc cgactcagga aaaatggaaa ttaacaagag 23820 ctataaagta atacagaaag ggacagtgct cccatctatg attaagtgca cgcaactaat 23880 tcatacttaa ggtttttttg tctccttccc ttgctctatt taaattgctg attctctcac 23940 acctgatgac tcttctctca aatgcccatc cttgatattt cctcgaagtt ttgtgcaccg 24000 agggcggcct gagcctctgg atcttcactt gggcatgttc ctgcccacct tgcttcacca 24060 ggcaactgcg gagcagcagg agcgcttctt catgcccgcc tggaacttgg agatcattgg 24120 cacttatgcc cagacagaga tgggtcatgg tatggagtat tcagtctacc ttctgggttg 24180 ggcgggcccc tgtgagctta ccatgtgtgg agtgcccacc atgtgccatc gatggtgtgt 24240 cgatgttcta tggtctgttt aaatgagctc tttctgcaga gtccaggttt tggtataaac 24300 actgctttgg tgagtgggaa ttaaagacca tgatactgat aaaatgattg tcctttttat 24360 accatagttc cccttcagag ggtcaagaat tgcaaatcag gccttattta ccaagtggtt 24420 tttcaatgtt actgaggttg tatagaatct gtgtgcatat acaacccgaa gctgtttttt 24480 tcttcattac tatctgatta cctttactac tgatacctta atgagtacaa attccagaag 24540 aaatacaaat aatagtttgt gtactcttgg atttgcttga gggaaatgag tagcttataa 24600 ctgacgtgtg tgacattttg gagttatttg tactttgagt caatcagtag ttctgcaagt 24660 gacttggctg gagagtgaaa aaaccaagat aagccgaact tgcaggcatt tggtttcaga 24720 ctctgtatct ccacctttca ttgatctttc caccccccac ctgctttctt catgcacctg 24780 ggtgggctgg aggtggccgc tgttcctctt tgtatcttct ctgaattggg tccgtgtttg 24840 ccattcattt gcttatggct tctctttttc tgctctgacg tttcagaaaa actggtctag 24900 tgtgtatttg ccacttgctc cttatttcta tacagctgct gctttttatt tggtgttgaa 24960 tagtatttta caggattttc atgagactcc aagtggaata ctatttgttt cagttgtgct 25020 tttgaaaaca ttttgtcctt atctgttctg tttaatgtta tctgcttttc tgtaaaagct 25080 gcttctttga tgaaagatgt ctgtgtctga tttgttgact cccactcggg aaagttgtgg 25140 attgcacata agttggttat tcaacttgga agcttctaaa tgtttcaaag tgtgtttaat 25200 gaggtctaag cgttatgaaa gcagattggt aaaaggttcc caacgtttgc tttagtacag 25260 tatttttgta gagactgcca cctagaacat ttttctatga ctcttttcaa ataattttga 25320 tatatttgtg ttaagattta aaacataaga tcctgtctat cccagtacac ataagaaact 25380 ggaaactctt ccttgccaca ttaatgaacc agcaggacta agttaggcct gccattggaa 25440 atctctaggg tcaactgaga ccttattatt ggacctttag gaatttttaa aagtcacatt 25500 tcaggtcatt tccccaataa cagttatact tttatacttt tttttttttt ttttttgaga 25560 cggagtcgtg ctctgtcgcc caggctggag tgcagtggcg cgatctcagc tcactgcaag 25620 ctccaccttc cgggttcacg ccattctcct gcctcagcct cccgagtagc tgggactaca 25680 ggcacccacc accatgccca gctaattttt tgtattttta gtagagacgg ggtttcgccg 25740 tgttaaccag gatggtctcg atctcctgac tttgtgatcc gcccgccttg gccccccaaa 25800 gtgctgggat tacaggcgtg agccaccgtg cccagcttta atttttttgt tgttttttta 25860 gtagagacgg ggtttcacca ctttagccag gatggtctca atctcctgac ctcgtgatcc 25920 ccccacctcg gcctcccaaa gtgctgggat tacaggcttg agccactgtg cctggccttt 25980 ttctttttct ttttcttttt tttttttttt tgagatggag tcttgctctg ccacccaggc 26040 tggagtgcgg tggcacaatc ttggctcact gcaacctcca cctcccgggt tcaagcaatt 26100 ctcctgcctc agcctcctta gtagctggga ctacaggcgc atgccacaat gcctggctaa 26160 ttttttgtat ttttagtaga gacgggtttc accatgttag ccaggatgga ctcgatctcc 26220 tgacctcgtg atccacccgc ctcggcctcc taaagtgctg ggattacagg catgagccac 26280 cacgcacagc catacatttt taatttatac gaattttggc tgaaatgtct tcctctcaca 26340 tgttatctca ttcttctcat tagtacagaa ttcaagaatg ttgaattggt gtggttaaca 26400 caatacatat gacttgaaat tggcatactt gcaactcaga gatgggttta aaaagacagt 26460 taacatccct gttaaattca tatattgtga tcttaaaaat gtgattctaa gttgccttta 26520 tattttcttt cagttgctgt aaataaatgt aacaaatcaa atacagaaat ggaacatgca 26580 tgacacttag attttcaact taataggaaa ccatcagata gtgtgggaaa ttcagtgtct 26640 tggttatcaa ccagttgtag ctcatctaca ggtgtttttt gttagatttt gtttttctct 26700 gagatatgag agtttaaagg actgtgcagg aaatttttcc ttgtgcctat ttttttcccc 26760 atctcttaac tgaagtcaat gtaatttatc tccttaggaa ctcaccttcg aggcttggaa 26820 accacagcca cgtatgaccc tgaaacccag gagttcattc tcaacagtcc tactgtgacc 26880 tccattaaat ggtggcctgg tgggcgtaag tgaatttttc agcatttatt ggatgttttg 26940 aaggtttgtc atgagatttt gcttagaatg tagagctttt atgataatgt cggccagact 27000 tggtggtgaa atcctaacac tttgggaggc tgaggtgggc agatcacttg aggtcaggaa 27060 ttcaagacca gcctggttaa tatgctgaaa ccccatctct actaaaaata caaaaattag 27120 ccgggtgtgg tggcgcacac ctgtagtccc agctacttgg gaggctgagg caggagaatc 27180 acttgaaccc gggaaggttg caatgagcca agattgcacc attgcactcc agcctgggca 27240 tcacagcaag actttgtctc aaaaacaacc caacaaacaa atatatgtgt gtgtggtgtg 27300 tgtacataga ggggtgtgtg tgtgtgtata tagacagaga gaggtgtgtg tgtgtatata 27360 tatatatata tatatatata tatatatata tagagagaga gagagagaga gagagagaga 27420 gagagagaga gagagagaga gagagagaga gaggaaagcc aggcatagcg gcacatacct 27480 atagacctat agtcctggct actcaggagg ctgaggtggg aggaccactt gagcccaaga 27540 gttcaagcct gcagtgagct actatctgtg atcatgccac tgcactccag cctgggtgac 27600 agagtgaaac cctgtctctt aaaaaaaaaa aagaaaaaaa tttaaatagt tttaacacaa 27660 actttttttt ttttttgaga tggagtctca ctgtgtcacc caggttggag tacagtggtg 27720 tgatctccgc tcactgcaac ctccaccttc tgggttcaag cgattctcct gcctcagcct 27780 cctgagtagc tgggactaca ggagcgtgcc accacaccca actaattttt gtatttttag 27840 tagagatggg atttcatcat gttggccagg ctggtctcaa actcctgacc tctggtctgc 27900 ccgcctcggc ctcccaaagt gctggaatta caggcgcgag ccaccgtgcc cggctgaccc 27960 gaaactttta tatcttctta ttccattctg agttattatc ttggaatata tatttccaat 28020 acagttagtg gttgaaggat tttgttattc acattatata ttttatttat ttataattta 28080 tatgtaagaa gccacatgta gctagtgatt actgttttgg acagcactgc cttaagggat 28140 aacaaggaag tagtttaaat taatattctt atttttatcc taaaattttc tctacgtaaa 28200 tgtatgagaa ataagtagaa aagaaagtaa taactattag cttaagggaa tttctttctg 28260 aaagctaggt gtgatgctgt cagcagaaag gctttctgga cacatactat tggtttagtc 28320 tagtgttaga tttaacatat tctttcttct tttttctacc ctttaaaaat gtatgaacgt 28380 ttgcccaccc ctcccttgtt ctctttgata ttacagttgg aaagacttca aatcatgcaa 28440 tagttcttgc ccagctcatc actaagggga aatgctatgg attacatgcc tttatcgtac 28500 ctattcgtga aatcgggacc cataagcctt tgccaggtaa gaactgttca tctgatgttg 28560 agatgaaaat gaaactgagc actttcttct gcaaaaggta gaatgcccaa ctgaagaggc 28620 ggagcaaaag ccagaaattc cagagcataa acatctcgtg actgtccttt catctgtggt 28680 aggaattacc gttggtgaca tcggccccaa atttggttat gatgagatag acaatggcta 28740 cctcaaaatg gacaaccatc gtattcccag agaaaacatg ctgatgaagt atgcccaggt 28800 atgttttgat agaaaataaa gcagaggcat caaacagtgg agttgagtgg ctgttactca 28860 caatagggtt agaatggtct gttcttttag aaggtaataa cagcagggca cactggcata 28920 ttcctgttat cccagcactt tgggaggctg agtgcgtgga tgacttgagc ccaggagctc 28980 aagatcagtc tgggcaacat agtgagaacc catctctaca aaaagtaaaa aaatctagct 29040 gggtatggtg gcacacgtgt gtagtcccag ctacttggga gactggggtg ggaggatcac 29100 ttgagcctgg gaggccgagg ctacagtgag ctgtgattat gccaccgtac tccagcctag 29160 atgacagtga gaccttgtct caaaaaaaaa aaggaggctg ggcgcagtgg ctcacacctg 29220 taattccagc acttttggga ggctgaggcg ggaagatcat gaggtcaaga gatggagacc 29280 atcctggcca acatggtgaa accccatctc tactaaaaat accaaaaaat tagctgggcg 29340 tggtggtgcg cacctgtagt cccagctact caggaggctg aggcaggaga atagcttgaa 29400 cccgggaggc ggaggttgca gtgagcagag atcatgacac tgcactccag cttggcaaca 29460 gagtgagact ccgtctcata aaaggaggga ataaggctgg gcgcggtggc tcatgcctgt 29520 agtcccagca ctttgggagg ccaaggagga tggatcataa ggtcaggaat tcaagaccag 29580 cctgaccaat atggtgaaaa cctgtctcta ctaaaaatac aaagattagc cgggtgtgat 29640 ggcacacgcc tgtaatctca gctactcagg aggctgaggc aggagaatcg cttgaaccca 29700 ggaggcagag gttgcagtaa gtcgagatca caccactgca ctccagccta ggcaatacag 29760 cgagactctg tctcaaaaaa aaaaaaaaaa aaaaaggagc taataatgca tttttccttc 29820 tgatgcccct tttttttttt tttgagagag agagtctctg tcacccatgc tggagtgcag 29880 tggcgtgatc ttggctcact gcaacctccg cctcctgggt tcaagcgatt ctcctgcctc 29940 agcctcccaa gtagctggga ttacaggcat gcgccaccac acccagctaa ttgttttgta 30000 tttttagtag aggtggggtt tcaccctgtt ggccaggctg gtctcaaact cctgacctca 30060 ggggaccctc ttgcctcggc ctcccaaagt gctaggatta caggcatgag ccaccgcacc 30120 cagcattttt tggttttttt ttttttttga gacagagtct tgctctgtca cccaggctgg 30180 agtgcagtgg cgcaatctca gctcactgaa acctccgcct cccaggttca agcgattctc 30240 ctgtctcagc tcctgagtag ctgggattac aggcacgtgc caccacacgc agctaatttt 30300 tgtattttta gtagagatgg ggtttcacca tgttggtcag gctggtctcg aattcctgac 30360 ctcttgatct gtctgccttg gcctcccaaa gtgctgggat tacaggcgtg agccatcacg 30420 cccactctga tgcttctttt actgcgacag tgaaatcaga aacagttgtc agggttgaag 30480 gacatatttt gatttgctaa accaatgatt ctcaaacttt tgcatgcgtt agaatcacct 30540 ggaaggccag ttaaagccca ggttgctagg ccctaccctg gagtttctga ttcagttggt 30600 cagggtgggg actaagatgt agtatttcat gcaagttgcc aggtgatgct gatgctgcta 30660 ttccagggac cacactttga gaaccactga actgcctctt gggcttaaaa gaaggaagta 30720 tcagttccac gttcttcttc caggtgaagc ctgatggcac atacgtgaaa ccgctgagta 30780 acaagctgac ttacgggacc atggtgtttg tcaggtcctt ccttgtggga gaagctgctc 30840 gggctctgtc taaggcgtgc accattgcca tccgatacag cgctgtgagg caccagtctg 30900 aaatcaagcc agggtaagga tagggtccta gatgggctca gtaccaaagg cctagttttt 30960 accccattca gatcccagaa ttcccaaatg tcaatacaga agatgcatta gcactgcaaa 31020 attggctagg gtgataactg ggcctgtaat ttcatatcta ggcttccttt tcttaagagg 31080 aaagacagaa ataaccaccc ttgctataat cagtgactgc caaaaaagaa aaaaagagaa 31140 tacccacctt attattttta actttttaag aaaaatagta ataatattac ttgaacttta 31200 taagtgaaat gttcaacaca ctaaaggcag tttgaaagtt ctgattacta ctagcaactg 31260 taaattgtgc atggtgaaag tgacattaaa tttgtttccc ttttgcattc atagccacag 31320 tttattccta caactgcctt tcactgatac tccctgatac tctttttact cctaaggaat 31380 aaagaaactg gccaggtgtg gtagctgaca cctgtaatcc cagcactttg ggaggctaag 31440 gcaagaagat tacttgagcc taggagtttg aggccaactt gagcaacata gtgagaccct 31500 gtctctattt tcttttcttt tttttttttt tttgagatgg attctcactc tgttgcccag 31560 actggagtgc agtggcgcga tctcagcttg ctgcagtctc tgccaccctg ggttcaagtg 31620 attctcctgt ctcagcctcc tgagtagctg ggattacagg tgcacgccac catgcccagc 31680 taatttttgt atttttagta gagacggaat ttcgccatgt tggccaggct ggtctatttt 31740 caaaaaaatt aaaagttaat taaattttaa ggccaggcgc agtggctcac gcctgtaatc 31800 tcagcacttt gggaggccaa agcgggtgga tcacttgaag tcaggagttc aagaccagcc 31860 tggccaacat ggagaaaccc cacgtctact aaaatacaaa aattagctgg gtgtggtggc 31920 gggtgcctgt aattccagct actcgggaga ctgaggcagg agaatcactt gaacccagga 31980 agtggaggtt gtagtgagcc gaaatcacaa cactgcactc catcctgggt gttagagact 32040 tcatctcaaa aaataataat aataattaca tttttaaaaa ggaataaagg aattgataca 32100 atgagaccct tgctaattct tacacttcaa aatatttaac accatccatt gggtcttctc 32160 caagattgtg gtcaaaatac aatgtattca gccatctggt gagtagagct ttttggcatt 32220 gccttcttat taggttgact agcgttggtt ttgtatgttg ctatgagcta cggttttctt 32280 agtcatactg gaaagactag gacagatatg gactttgcag ccagaaaatt ctgtcagcct 32340 acgcagtaca aggtaattac agcatggtct tagggagcca aatagcctag gcaccgtggc 32400 tcatgcctgt aatcccacca ctgtgggagg ctgaggcaag agaatcgctt gaacttggga 32460 ggcggagctt gcagtgagcc aagatcgcac cactgcacta aagcctgggt gacagaggga 32520 gactccatca caaaaaaaaa aaaaaaaaaa aaaaagcctc aatttaaatc taagacctgc 32580 cacatacgag ctgtgtgacc tcaggcagat tcttaacctc tcagtttccc atttgtaaaa 32640 tggagatagt aatagtaact acctcacagt gcccttaaga ggactaaata agttaaaata 32700 ccaagtgctt agattagaac ctggcatata gaaagttctg tataaacatt tacttactac 32760 tttttttctt tttctatgtc acgtagtgaa ccagaaccac agattttgga ttttcaaacc 32820 cagcagtata aactctttcc actcctggcc actgcctatg ccttccagtt tgtgggcgca 32880 tacatgaagg agacctatca ccggattaac gaaggcattg gtcaagggga cctgagtgaa 32940 ctgcctgagg tatgagtttg gtctcattca ctcatgggca cccttctgtt tcgtggttgc 33000 ctgttggatg aggtccagag ataactaaat gttggtattt cctgaaaaga agtatgtatt 33060 ctgagaactt cttctggttg aaagtagatc agatatgaag atctgtgggg tttgttgttc 33120 agtattttta gtgttatcag aaatactgta ccatgttgat tatttgtcaa tcaaggaaat 33180 gtaagtggtg aatgtttagc caagtagaac agcttagatg ggcatgggta gtgttctgta 33240 ttcttctggc cagtcggaca gctgtgcttc ttcagtttgc atgtgtggca gctgtgtttt 33300 gacagtggcc aagatgttag aggaggggtg tgttttctca ttggttctcg ggctctcagc 33360 accacagatg tcctgacaga tctgtgcttg tcctctcagc ttcatgccct caccgctgga 33420 ctgaaggctt tcacctcctg gactgcaaac actggcattg aagcatgtcg gatggcttgt 33480 ggtgggcatg gctattctca ttgcagtggt cttccaaata tttatgtcaa tttcacccca 33540 agctgtacct ttgagggaga aaacactgtc atgatgctcc agacggctag gtgagagtca 33600 aatcctcgat tcctcccatc tgttcataag aatgttctag tccttttcct aggttcttgt 33660 tcccatggtt tttcttcacc gtatatatat atttgttcct gaaaggtata cttttgcctt 33720 ccatcctgac tcacggtttt tatttcgtgg tgaggctaga gagtatgaag cacctgttac 33780 atagcttgca gttgtatcaa ggatagagtt actgggctgg gcacagtggc tcatgactgt 33840 aatcccagca ctttgggaag ctgaggtggg cagatcatga ggtaaggagt tcaagaccag 33900 cttgatcaac atggtgaaac cgtgtctcta ctaaaaaaat acaaaaaaat tagccgggca 33960 tgatggcaca ttgcctgtaa tcccggccta cttgggaggc tgaggcagaa gaatcgcttg 34020 aacctgggaa gcggaggttg cagtgagcca agattgcgct attgcactcc atcctgggca 34080 acaagagcga aaactccatc aaaaaaaaaa aggccaggtg tggtggctta ctcctgtaat 34140 cccagcactt tgggacgcca agccgggtag atcacttgag gtcaggagtt aagagaccag 34200 cctggccaac atggtaaaac cctgtctcta ctaaaaaaac aaaatattaa aaattagcca 34260 ggaatggtgg caggtgcctg tagtcccagc tacttgggag gctgaggcag gagaatcatt 34320 catttgaacc caagaggagg aggttgcagt gagctgagat ctggccattg cactccatcc 34380 agcctaggca acaagaatga aactccatct caaaagaaac aaaagaaagt agagttacta 34440 aaagcatgtt tactggtgac ttttaggttc ctgatgaaaa gttatgatca ggtgcactca 34500 ggaaagttgg tgtgtggcat ggtgtcctat ttgaacgacc tgcccagtca gcgcatccag 34560 ccacagcagg tagcagtctg gccaaccatg gtggatatca acagccccga aagcctaacc 34620 gaagcatata aactccgtgc agccaggtga gctctccctc aagagctaga atacgcagca 34680 gtggggctgg ggccctgaca gatggcaaga aggcatgagt actgttgatc atttcctcag 34740 acctccaatc tatgtcttaa cagattagta gaaattgctg caaaaaacct tcaaaaagaa 34800 gtgattcaca gaaaaagcaa ggaggtagct tggaacctaa cttctgttga ccttgttcga 34860 gcaagtgagg tcagtggtag ttctctcttt ttccccttcc ctgccctcag catcccgcat 34920 tttctggtac agaaacccta gtcactgtat attgaatctt tttccaaggt tctcaaactc 34980 tggtgttttc tttttaatct taggcacatt gccactatgt ggtagttaag ctcttttcag 35040 aaaaactcct caaaattcaa gataaagcca ttcaagctgt cttaaggagt ttatgtctgc 35100 tgtattctct gtatggaatc agtcagaacg cgggggattt ccttcaggtc agtattttct 35160 aagtataagt cttttttgtt gttgttttaa gaaaaataat tgttggctgg gcacggtggc 35220 tcatgcctgt aatcccagca ctttgggagc ccaaggcggg tacggtgatc acttgaggtc 35280 aggagttcaa gaccagcctg gcctggtgaa accctgtctc tactaaaaat acaaaaatta 35340 gccaggtgca gtggcacatg cctgtaatcc cagctactag ggaggctgag gcacgagaat 35400 catttgaacc ctggaggcag aggttgcagt gagccaagat gaaaccactg cattccagcc 35460 tgggtgacag agcaatactc tgtctcaaaa aaaaaaaaaa agaaaaagaa aaatagccag 35520 gcacagtggc tcatgcctgt aatcccaaca ctttggccaa ggcgggcaga tcacctgagg 35580 tcgggagttc gagaccagcc tgaccaacat ggagaaaccc catctctact aaaaatacaa 35640 aattagccag gtgtgctggc gcatgcctgt aattccagct atttgggagg ccaagggagg 35700 agaattgctt gaacctggga ggcggagatt gcggtgagcc aagatcacac cattgtactc 35760 cagcctgggc aacaagagtg aaactcagtc tcaaaaaaaa aaaaagaaaa aaataattgt 35820 catccgcttt atagctgtat atgcatataa ttatgtctat ctatatacat atatatgttt 35880 tatttactta ttttggtctc ttttagggga gcatcatgac agagcctcag attacacaag 35940 taaaccagcg tgtaaaggag ttactcactc tgattcgctc agatgctgtt gctttggttg 36000 atgcatttga ttttcaggat gtgacacttg gctctgtgct tggccgctat gatgggaatg 36060 tgtatgaaaa cttgtttgag tgggctaaga actccccact gaacaaagca gaggtaaaaa 36120 tccagtgtct ctgcaccttt ttaaaagtct tcacttaaat attgaagcag gaaaggcctc 36180 tcgaagggga tttatctgtg aaagctctga aagtaccatg gccacttctg acagtcactt 36240 tatttgagca acaggttcag aagggaactg ggttgttccc acagtaacca gggtcttaat 36300 caatttcaat ttttgataac gaattgaaca tttaaaaata tatacaggcc gggtgcgttg 36360 gctcacacct gtaatcccag cactgtggga ggccgagtgg gcagatcacc tgaggtcagg 36420 agttcgagac tagcctggct aaaatggcga aacccaatct ctactaaaaa tacaaaaaaa 36480 gcagccaggc agtaatggtg cacggctgta gtcccagcta ctcgggaatt ctcctgcctc 36540 agcttgaacc caggagaacc caggaggcgg aggttgcagt gagccacgtt cgtgccattg 36600 cactccagcc tgggtgacaa gagcaaaact ctgtctcaaa aaaaaaaaaa aagtatacac 36660 acacacacac acacacaaat agaataaaat atacaaaaag agaattccgt agtgctcttt 36720 ggtacaccct ttgtctagca gcaatgacta tcaactcgtg gctagttgtg tttcatctga 36780 accttcatcc ccctcctcct ggggactatt ttgaaataaa tctaagacat cagggccagg 36840 ctcagtgatg cacacctggg aggccgaggc aggtggatca cctgaggtcg ggagtttgag 36900 accagcctga ccaacatgga gaaaccttgt ttctactaaa aatacaaaat tagccaggcg 36960 tggtggcgca tgcctgtaat cccagctact tgggaggctg agacaggaga attgcttgag 37020 cctgggaggc ggaggttgcg gtgagccgag accatgccat tgcactccag cctgggcaac 37080 aagagcgagg ctccgtttca aaaaaaaaaa aaaaactaag acatcagata attttatcca 37140 taaataattc aatgcatagc tctaaaagat aaggactctt cagaaacaac cacaggctgg 37200 gcacagtggc tcacgcctgt aatcctagca ctttgggagg ctgaggtggg tggatcactt 37260 gaattgagga gttctagacc agcctggcca acatggtaaa cccccatctc tacaaaaaaa 37320 tacaaatagc agccaggtgt catggcacac acctgtagtt ctagcaactc gggaggctaa 37380 ggtgggaaga tcgctggagt ctgggaggca gaggctgtag tgagccaaga ttgtgccact 37440 gcactccagc ctgagcaaca gagcaggact cagtctcaaa aaaaaaacaa aaacaaaaac 37500 aaaaaacagt atactattta acatggcaaa ctctttatta gtagttcttc tctctccttt 37560 ccccacaggt ccacgaatct tacaagcacc tgaagtcact gcagtccaag ctctgaagtg 37620 tcacaaggac aagtttaatc tgcttcagaa agcgcctgtg tgcaactcaa attttgtgga 37680 atctttttcg aattcaaata gctatagagc aaatgataaa ttgacccctt tttataaatg 37740 gagggaaaaa atgaacagat ttcagagatt aaatgaaaaa aagcagatgt tttaagtgca 37800 attaacactg aaagagacct gttaaaccat tcagaaaaag cttaagaaat gcgatatgac 37860 ttccttttgt aatgctgctg atcccagtag actatgactt ttgataatta gcagaattta 37920 actactgagt agttgattat tttcacattt taattgctaa tcactggcta tataagtgtt 37980 tttaagcaaa ggtatttttg aagtggtgta gaacccttcc aagctttcct gctcagtgtt 38040 ctaccagact taccctgggg cctggcttaa aagcaggatt gaagaaaagg gactggggga 38100 aggaaactta ttggaaaact tgatgcgaat gagtttctgc ttggcacagt ctctgcctgc 38160 ttgctctcct ttgctgatgg attgcattta tcaaactatt catgctagca tttttccaac 38220 gagggaactt attccgcacg ggcctactgt aggaccattg tctcgtgtaa ttaggaattt 38280 tccatttgaa ggattgctaa attgtcacag tagtaggaag tatagggaaa cctctcagct 38340 gtggcactgt tgtagctttg gagtgcagag tgtaactctg ggacaatcag atttcacata 38400 ttctgtcatc ttggcataag ccattaaaag cttggagatt actgtatttg gcattaaaaa 38460 aaaatgtcac ttaggtcagc actcccagac gtagcacaga aaaacccttt gacacaaacc 38520 atgtgttctg atttttggtt cagaaaatat tgaaactgtg agttgttttt tttttaacaa 38580 ctgggaaaaa acaaaaacaa aaaactatag ttagaaaaat ggaagttcca taggttctat 38640 ttcttactct atgtatggct ttgttttcag tctatttcta ggagctttct ctgaatcgct 38700 aattgtcctt tcagttgaaa tctaatttat acaatcattc tatacttaaa ggttaaatac 38760 atcttaatta attttttctt aaagtcaatg taagtcactt tgttttgttt ttttttaatc 38820 tacgccatat gcctcatgaa accagctgtt ctagaatcag tcctgagaat atggcttaat 38880 tccatggaaa cataactcct atcttgggac ctgacataat atctatctat cctggggaac 38940 tggtaatatg agacttatag gttacagcag aaatgctaca tgttgacaaa agccttaatc 39000 gttccactgg gagaactaat tgataattgt gttaagattg aagattaacc ctgtgttaat 39060 ctcacttgag tctatcctga cagtagttca gattctggaa aatgataaac tgacctgcta 39120 gatgtagaat tgtttcaaaa ttagtgttga aataccttgt tcacagatga atatctgggc 39180 aggatctgag ggtgtttgga atgacacccc ccaatccagt tgcatagatg ggatgtcttt 39240 gcaggtttga ggagatcatc gacctgcaga gccccctttg acccagtacc tcacgtttta 39300 tttaaaatct aaatctgggg ccaggcgtgg tggctcacgc ctgtaatcca agcactttgg 39360 gaggccgaag cgggtggatc acctgaggtc aggagtttga gaccatcctg gccaacatgg 39420 tgaaaccccg tctctactga aaaaaataca aaaattagct gggcatggtg gtagcacgcg 39480 cctgtagtcc cagctactcg ggaggctgag gcaggataat cgcttgaact tggcgggtag 39540 aggttgcagt gagccaagat ggtgccacta cactgcagcc tgggtggctg agcgagactc 39600 cgtctcaaaa aaaaaatcta aatctgacat ttgatgctat ttttattaat attggaatgt 39660 tctgtcttga actttattca atataatcaa gaataaagat agagtaaacg tcactgattt 39720 gtactattaa gagagaaaaa atatgccaca caactaaaca taggtttaaa ttatgaagaa 39780 atttagaata gaggtttatt agatttaggg aacactaaga acaaaaaagg aaggagtgat 39840 acctgcctga gtggacagct gtaaatcagc tgtaattact gcagttgtac caatagttgt 39900 gagtggctcc agtcacttta ggagtccttg gaagtacttg gtacacattt gttggctgta 39960 ccttaaagga agtggcaagt ccagtttgtt ctctctacca cactagactg ccactgacaa 40020 gtttgggtct gttggattca aaattttgta agccattttc acaagtacaa agatacattt 40080 taaccttgtc ttctccaaaa ttactgagta ggaattttat ttttatcttt ttgagacagg 40140 gtatcactgt cacccagact ggagtgcagt ggtgggatct tggcttactg tgacctctgc 40200 ctcccgggtt caaatggtcc tccctcctca gtctcctgag tagctgggac gacaggcacg 40260 tgccaccatg cccagctaat ttgttctatt ttttctgtag agacggggtt ttgccatgtt 40320 gcccaggctg gtctcagact cctgggctca agcgatcatt tcgcctcagc ctcccaaagt 40380 gctgagatta taggtgtgag ccacagcatc tggcccagag tgaggagaat taatgagatt 40440 ttttgtgtgt gttagataat attgatttaa gccttttttt aaaaagtact ctcaaccaaa 40500 tacaaaattg aaaatgtgag gtttaataga aatgtgttgg ctatttgcaa tggattttct 40560 tcttgcccaa gtgtttggag ttctacttta tgctctgtat ttaaaaatta gtgacctcaa 40620 agcagagttg atgacacagg ctttggggcc ctcatgttct tgtctttaga acatatcact 40680 actaagtatc agcttatctt cagaacatta caacattcac cgtgttcata tgctttctga 40740 gaagtcacca cttgtaattt cagatcacat acacctgaag gcattttata gttcctaaag 40800 ttaacatgtt agatcttttt tttccacccc atgagggtct cactctcacc caggctggaa 40860 tgcagtggtg tgattgtagc acactttggc caccaactcc tgggctcaag tgatcctcct 40920 gctttggcct cctctgagaa gctgggatta ctggtgcaca ccaccacacc tggctaattt 40980 tttatttttt tttatttttg gaaatagggt atggctatgt tgccttgggc ccgtcatgaa 41040 ctcctagcct caggtgaccc tcccacctca ggcctcccaa agggttggga ttacaggagt 41100 gagctactgc actgggccaa catgttaatt tttttttttt tttttttgag atggagtctc 41160 ccaggcggga atgcaatggt gcgatctcga cttcactgca atcttcacct cccgggttcg 41220 agcgattctc ccacctcagc ctcctgagta gctgggatta caggcacctg ccatcacgct 41280 cggctaattt ttgtattttg agcagagatg gagtttcacc atgttggcca ggtgatctgc 41340 actcccactc cccccacact tcccaaagtg ctgggattac aggcataagc cacaagccac 41400 ctcacccagc caacatgtta catcttaatt cttggatttt cttcactgca gggctttggg 41460 tggagaaata aaactcttca aatgcatgat cttggagatc cctgtgaatc aataattctt 41520 tagacaactg cggctcaaaa tccctccttt cccttttccg agttattcca tccatcttat 41580 tagaaaggaa gtgaattagg tgtaggtggt ctgtaacacc tgcacatctt tttatacgtg 41640 tagagggtat gcctgggata tataggttgt cttcaagcag tagctgctac tacagctaga 41700 gagaggagga gtgccaggaa actgatgacc tgagaccaag agtcttgttg atgttctgac 41760 ttagataaag gttttgatca ttttcatgaa ataatgcagg gaagtcattt ctgctgtttc 41820 tttactactc cattcttgga ggattagaac aagtcacact gtaattgact aaaacgactt 41880 tttattttaa aatattgatg gtggggtttt gctttttttt tttttttttt ttttgagacg 41940 ttgtcttgct ctttcaccca gggtagagtg cagtggcgaa atcttggctc actgcaacct 42000 ctgcctcccg ggttcaagca attctctgcc tcagcctcct gagaagctgg gattacagcg 42060 cctgccacca tgcctgtcta gtttttttgt atttttagta gagacagggg tttcaccaag 42120 ttggccaggc tggtcttgaa ctcctgacct cgtgatccac ccacctcggc ctcccaaagt 42180 gctgggatta caggcgtgag ccaccgtgcc gggccagtgt ttttaactgt ccacacttac 42240 taaattttcc agtacttctt cctatggttc atgatagtaa acacagaaac atataaggaa 42300 cattattaga gttaccagat gttagctgtt gcatatgtgc acattcctag attcaagggt 42360 gtttttgcct taaatttaag tgggtcattg gttgtcttgg gaagatcatg gaaaattcgg 42420 gattttttag aattctgaac caaaatatgt tttgagtgtt tcttagtaaa tgtgtgatct 42480 tccaccttcc acattcagac tgcggactac acttcataaa tgccttttta tttccagtta 42540 tggattcaac taaatgactg ccttgggagc acataattac tttgctacct ttttccccct 42600 ttgctgttgt ggctcgagtt tggttctcac ctgagaagat gcattgagca tatgttgtta 42660 cccagccctg gcttaatggt gtcctgtggg gtaggggtgg gaggacgagg ggcacggggc 42720 cagagcatgt gaatggatca tggttggaca gctgtgacct gccagcactg cgggtaagca 42780 aaactacaaa ccgttctttc ctctgtgaca ttgaataaac cttaataaaa ttcataatta 42840 gcacatacta gaaaaaatgt gacttaatct ttttgtgggg cgacagtatt gggtttcatt 42900 ctggctatac agctttgatt ggatcattaa acaggtcagt cacttccctc aagctttggg 42960 gtgtggaata aacaccggtg aatttgtgga ttcacccgtc aacctcccaa tatcaacaca 43020 tttctcacgc ctccgcgtcg gccacgtgtc agccctcaga agtgggcagg aggaactttt 43080 aagcttcccg gcagttccca agagggcctt tgagcctggc gccctcttcc cggagaggcg 43140 ttggggcagc tcctagcaac gtgcccgccg ccggcagaag cccggccccg ccaactgccg 43200 cgcgcggctc cctgggagct gtagttcttc atggcgtccc cacctcctct gtgagggcgg 43260 gtgagtcgac cgccgactgc gactcccagg atgcctcgcg cccgcctttc cgcgggaggc 43320 cagacggctg agggtgccgg cagcggctgg aagcgggagg ccagtcctgg ccgggctggg 43380 cgacccgaat ggagccaggg ccggcgctgg tcccagcggc cgcacctccg ggggcacggc 43440 gcgtaacagg aggcttccgg ggctgagagc gttacaggct gcgctccggg gccagatagg 43500 ccgggcgctc agaagggtga cgcattgagg ggcgcggagt ctcgggacgg aggggcgact 43560 ccggctaggg gtcttgctta ggggtggtct cgggatctgt aaaacgcctg gcatggagtc 43620 ggctgaatac atgtggggac ggggttactc tgtagccctt tggccttggc aaaccaagcc 43680 tagaaaatcc ccatagtctg agaagcccgt acaggatcga taggagatgc cagaagttcc 43740 ttgatgtgtt atgggacaca tttggacttg taggtcgtga agtcgccatt gcagagaaaa 43800 agaaacaagg ccgggcacgg tggctcacgc ctgtaatccc gacactttgg gaggccaagg 43860 cgggaggatc acttgaggcc aggcgtctgg gacgaccctg ggcaacatag ggagaccccc 43920 gtctctacaa aaaaaatttt aaaatttgcc gcacatggtg gcgtgtgcct gtggtcccag 43980 ctgctaggga ggctgacatt ggaggatcgc ctgagcccaa ggaggtcgag gctgcagtaa 44040 gctatgagag ctgtgatcgt gccactgcac tccagcctgg gcaacagagc gagaccctgt 44100 ctggaaaaaa aaaaaagaaa gaaggccagg cgtggtggct cacacctgta atcctagcac 44160 tttgggaggc cgagacgggc agatcacgag gtcaggagtt cgagacctcc tggccaacag 44220 tgaaaccccg tctctactaa aaatacaaaa attaaccggg catggtggca tgtgcctgta 44280 ttcccagcta ctcgggaggc tgaggcagga gattcgcttg aacccgggag gctgaggttg 44340 tggtgagcca agatcgcacc actgcactcc atcctgggca acagagcaag actccgtcta 44400 aaaaaagaaa aaaaagaaaa cacatgtatt cagggtgggc tctgtaggta agcccagata 44460 acccttgcat tccaataaca ggacaggcca atacttggga cataaagagg acccctctga 44520 ctcctttctt ccaggacatc ctgtaggtgg gttttggtaa agtggaggag ggggagggag 44580 acagctaatt ccgaggaaaa tgttctcaat gggtcagatt tactgcctat gtaaagggaa 44640 atatttccac tgtcagtgaa aatcgtgttg ctggacgtgg tggctcacac ctgtaatccc 44700 agcactttgg aagaccaacg caggaggatt gcttgagccc cagagttcaa taccaacctg 44760 agtaacacag tgagaccccg tctcgaaaaa aaaaatttta aaaagaaaaa gaatatcaaa 44820 gagtaaccag agttcatacc tgcttttgtg ctaaatg 44857 <210> 26 <211> 56055 <212> DNA <213> Homo sapiens <400> 26 ttatgggaag tgctgtattt cagcgcacac tctgaatagc ataatcatta ctaaaagaat 60 tttttttttg agacggggtc tcactctgtc tcccaggctg gagtgcggtg gtgtgaacac 120 ggctcactac agcctcaacc ttccaggctc aggtgatcct cccacatcag cctcctaaac 180 agctgggact acaggtgcag gccactgcac caggctaatt ttctgtgggt tttgttgttg 240 ttattgtttg tagagatggg ttttgctatg tttcccaggc tggtcttgaa ctcctgggct 300 caagtgatct gcccgccttg gcaggactac aggtgtgagc cattgcaccc tgcctaccct 360 ggcccattga ctattatgaa ttaaaggcta ttgaaaaaca gcaggtgcat cgctggcaaa 420 agtatacttg tgtaacgaac ttgcacattc tgcgcatgta tttcagaact taaagtaaaa 480 ataaaataat aaagtaggcc gggcgtggtg gctcacgcct gtaatcccag cactttggga 540 ggccgaggca ggtggatcac aaggtcagga gatagagacc agcctggcta acatggtgaa 600 accctgtctc tactaaaaat acaaaattta gccgggtgtg gtggcgggca cctgtagtcc 660 cagctacttg ggaggctgag gcaggagaat ggcgtgaacc caggaggcgg agcttgcagt 720 gagctaagat catgccactg cactccagac tgggcgacac agcaagactc tgtctccaaa 780 aaattaaaaa aaaaataata aagtattcag ggataaagag agaaaaataa atttagattg 840 tatacatatg taaaatatat tttaaaaggt aagcttgtct tttttattcc ttaaaggagc 900 agatattaaa aaaaaaagaa tagaataact catcttttta gcctccacat atttacttgc 960 ttcttcccaa gttacttggt ctaattcagt atataagtaa ctgactctca ctgctttttc 1020 tgtgccatgt aaaacttgca ttgtattaat ttgtgtgctt ttctcctgtg gacctgtctt 1080 atgtcaactt aattctcagg cccagccaaa aaaaaaatac ccttaaaggg agcttagctt 1140 gcctccatga ccctcaatgg tggctgtaat caaaccacat cttccaggca aacaatacca 1200 catcctatgg ccttgcaatg gcatggcctc cctccagcac agcctctctg gaggaggggg 1260 aggcaagggt ggtgagatct caggcctccc tcatgctacc tcctattagt tatatgaccc 1320 ctggtgtcac ctctcccacc acactgtagg ctccagggag taggattcac atggggttca 1380 tttgtcctcc ctgccttcag cagactccag gcacaggtgt tcccagagta aagggctcac 1440 tgtctgcttc ctgggtgaat cattctcccc gcaaacccat gaggtgagtg cagtcgtggc 1500 ttcagctcac cgcctgacag gctccaggct gtagcacagg gagggccctg tggactctgc 1560 tgaggaacca tacgagctcc cagaggccaa gtgcaggaca gagaatagag aagcagctgc 1620 tcagagaact ctagccctgt agaggtgcaa atatggctgc tattatacag aaggtgaggc 1680 caaaaatgct ggagacactg ctcctgaatc tcagttttgc cacttgtaaa acagggaaaa 1740 caacctactc tcatgtcccc aggttgttag gaaaatccac tacatgaaga tgtgcagtct 1800 ctggctggga gcaggacacc agctgcccaa cagcacaggc tcagggcatg gcactgtctc 1860 cactgtcccc atccccaacc tggaagctag agcctcgctg ccctgccact tctggatgca 1920 ggacagagaa ccggaactgg gactgtggtc tctcagtaga ggctgtgaac agccatctgt 1980 ggccacacgg attgagacct ttcctgctca ctcttcaaac tggggcaccg gctgggtgcc 2040 caacagaaag acaattggaa gagtggcagg taaaccaggc tgtggccctg cagtgccatc 2100 accgtcctca tttgaattct ggctcgtctg ttcctctacg gcccctccgc atggcgctcc 2160 accccagtct tcagaaattt ctgcctcaag ctcagggagc tggtactgag gtacaggtag 2220 gagaaggtgc agcctctgct gagtggagga catgtgccct ggggatccag agtctagagt 2280 gactgacacc agccctgcaa tttgtcctcc tagacctgtt aacagagcct gcagaagttt 2340 acacagggct gctgaagatt tttatcccct cattttacag gaaggagctg gggccatacc 2400 agagtcagag ctggaccggg agcacggcag ggcccagcca tccacagcct ccaatttcag 2460 tactctctaa caacctgaga gcctgagcct tcggatcttc ttgattccta ctttgataaa 2520 gagagggatg gggttggaag gacctggcat agagattgga ccagtccggc attgacagag 2580 ccaggacctg gggtccggaa ctgagctcag ctccaggctc atctgaagtc accctgacag 2640 cctgaggatg gagaccttat ttccattaac aggcatggcg gttggcaggg actggcccca 2700 gctgagcacg gttttccaag tacacagctg ggaattaagt cttctctgcc gccctcccct 2760 gtagtcttgc ctggatcccc ccagtcatct actcccagta ccaaaaactc ctgtattctt 2820 gaaaatccgt agtactgaga ggtgacagct tgctggcagt cctcaacagc cctcgctcgc 2880 tctcggcgcc tcctctgcct gggctcccac tttggcggca cttgaggagc ccttcagccc 2940 accgctgcac tgtgggagcc cttttctggg ctggccaagg ctggagcccg ctccctcagc 3000 ttgcacggag gtgtggaggg agaggcgcga gcgggaaccg gggctgcgcg cgcggcactt 3060 gcgggccagc tggagttccg ggtgggcgtg ggctcggcgg gccctgcact cggagcagcc 3120 ggccggccct gccggccccg ggcaatgagg ggtttagcac ccgggccagc ggctgcggag 3180 ggtgtactgg gtcccccagc agtgccggcc cactggcgct gcgcttgatt tctcgccggg 3240 ccttagctgc cttcccgacg ggcagggctc gggaccgcca tgcctgagcc tctcaccccc 3300 tccgtgggct cctgtgcagc cggagcctcc ccgacgagca cctccccctg ctccagggcg 3360 cccagtccca tcgaccaccc aagggctgag gagtgcgggc gcacggcgcg ggagcacggc 3420 gcgggactgg caggcagctc cacctgcaac cccggtgcgg gatccactgg gtgacgacac 3480 ctgggctcct gagtctggtg gggacgtgga gaacctttat gtttagctaa gggattgtaa 3540 atacaccaat tggcactgtg tatctagctc aagttttgta aacacaccaa tcagcaccgt 3600 gtgtctagct cagggtttgt gaatgcacca attgacactc tgtatctagc tagtctggtg 3660 gggccttgga gaacctttgt gtccacactc tgtatctagc taatctggtg gggaagtgga 3720 gaacatttgt gtctagctca gggattgtaa accaccaatc agcgccctgt caaaacagac 3780 cactccgctc taccaatcag cagggtgtgg gtggggccag ataagagaat aaaagcaggc 3840 tgccagagcc agcagtggta acactgtgga agcttccttc tttccctctg caataaatct 3900 tgctactgct cactctttgg gtccacactg cctttatgag ctgtaacact caccttgaag 3960 gtctgcagct tcactcttga agccagcgag accacgagcc caccaggagg aaagaacaac 4020 tccagaccca ctgccttaag agctgtaaca ctcactggga aggtctgcag cttcactcct 4080 gagccagtga gaccacgaac ccaccagaag gaagaaactc cgaacacatc cgaacatcag 4140 aaggaacaaa ctccagacac gccgccttta agaactgtaa cactcaccgc gagggtccga 4200 ggcttcattc ttgaaggcag tgagaccaag aacccaccaa ttccggacac agtaccatga 4260 aggaatgaaa atacataaca atgtgatgta tcatgtttta tttcctagac tagtgacaaa 4320 tgaaagctaa gtgtagcaag ggtgcaggga cacaggcaca tttgtggact aggtgtgagt 4380 gtaagctggg ttcgatggtc ttttggccaa catagtgaac ccctgtgtct actaaaaata 4440 caaaaattag ccaggcgtgg tggtgcaggc ctgtagtccc agctacatgg gaggctgagg 4500 tgggagtatc gcttgaacct gggagacgga agttgcagtg agccgggatc acaccaccgc 4560 tcaccaatct gagccacaga gagactgtct caaaaaataa accacaagga agggaggtag 4620 ggggaggggg agggagggag gaaagagaaa gagagaaagg aaggaaagag aaagcaggaa 4680 ggacggaaag aagacgaaag aacgaaagaa aacgaaagaa aaaaggaaag aagagagaag 4740 gagagaacag aaggggcagg tgcccctggg aaggggagaa gatcaagacg cgcctggaaa 4800 gcggactctg aacctcaaga ccctgttcac agccaagcgc gcgaccccgg gaggcgtcaa 4860 ctccccaagt gcctccctca actcatttcc cccaagtttc ggtgcctgtc ctggcgcgga 4920 caggacccag aaacaaacca cagcccgggg cgcagccgcc agggcgaagg ttagttccgg 4980 tcccttcccc tcccctcccc acttggacgc gcttgcggag gattgcgttg acgagactct 5040 tatttattgt caccaacctg tggtggaatt tgcagttgca cattggatct gattcgcccc 5100 gccccgaatg acgcctgccc ggaggcagtg aaagtacagc cgcgccgccc caagtcagcc 5160 tggacacata aatcagcacg cggccggaga accccgcaat ctctgcgccc acaaaataca 5220 ccgacgatgc ccgatctact ttaagggctg aaacccacgg gcctgagaga ctataagagc 5280 gttccctacc gccatggaac aacggggaca gaacgccccg gccgcttcgg gggcccggaa 5340 aaggcacggc ccaggaccca gggaggcgcg gggagccagg cctgggcccc gggtccccaa 5400 gacccttgtg ctcgttgtcg ccgcggtcct gctgttggtg agtccccgcc gcggtccctg 5460 gctggggaag agcgtgcctg gcgcctggag agggcaggga gagaggggga cacggcgggg 5520 gtgcgtggcc cgggtcgcct gcggccgggc atgtccgggc aagacgcacc agtcgtcgga 5580 gtcgggggaa gagatgggtc cccgggttgg gcaggagcga cctgggccgc cagggaacag 5640 agcgcgcgct ccacttggtg taaattcccg aatccagtgg gggagggcga caaggaggga 5700 attcccgagt aagctgcgtg aagccacgga gaggtcgtcg gactttgatt ttgttttctt 5760 tccttacttt ctgtttcttt ctctttttct ctttcttcct ttctttccct cccttccttc 5820 ctcgctcagt tcctgcctta atttcttttt cttttgcgcc ttcgaatgaa ttcctaaagg 5880 cgctcattgc agatcgcttt gaacctgcgg ccggcgaaga actcccctgt ggtcgctgcg 5940 gcccagtggt tccgttccgt gcgcgggagt cgtcgcgggc gcagctggag aggccccttc 6000 ccctccttag cggctgcgcc cctacgcgtg cggggccgct catcgccaat gccattgttt 6060 ggggttcctt gggaaaacga gatttaggag aagggagttg tggcacttgg ggcctgacct 6120 gcttgataat agcagctgca ttttggcctg ggaagagcct ttcttgccac ctcttggcaa 6180 gtatccgtga taatggggaa gggacaaaga gtcggctttg tagggaacag catggtgtgc 6240 tcagcgcctg gaactgcgct tggggccagg agaggttctg aatcatcaca ttttacagag 6300 gaagagaccg cagctcagag tggggaagtg tgtgggccta gacctaactc aagactgtac 6360 agaggggctg gaagggagag gaggaacagt gaaaggaagg tcaagagaat gctggtgttg 6420 acctagaaga atgtcagtgt gaagcattgg agtttcatgg gatattgtta cacacctcat 6480 gttttcactg tttccgcccc acaccacagt atgtccttgg tctcacctct gagtggaggg 6540 aggacctaac tgtcctagtg aggagagtgt acaggggcct ctgcctcccc ctcctgctgt 6600 ggtttctgtg ggcctaggtc cccagggcat cttgcctctc tttgggtggt ggatctttgg 6660 tctctggctg cttttaaaga tttttcttag cactggtttg cagtgatttg gtttgtttgc 6720 tctgttgtgg ggtttttttt ttatctctat aaagaatttt ttggattttt ggctttagac 6780 tttcatgttc tttctacttg gaagattttt ctgtaaagaa agccacaact gggttgtgtt 6840 gaatttcttg gatttggggt tttagagttt atgttctcct tggagacttt tctgtaaaga 6900 aagccacaac agccgggtct ggtagctcat gcctgtaatc ccagcacttt gggaggccga 6960 ggcgggcaga tcacatgagg tcagggattc gagaccagcc tgaccaacat ggtgaaaccc 7020 cgtctctact aaaaatacaa aattagctgg gtgtggtggt gggcacctgc aatcccagct 7080 acttgggagg ttgaggcagg agaatcactt gaacctggga ggcagaagtt gcagtgagca 7140 gagatggcgc cactgcactc cagcctggga gacaagagca agactccaac tcaaaaaaaa 7200 gaaagaaaga aagccacaac agagttatgt tgaatttctt ggatttgggg ttttagagtt 7260 tatgtttttg tttgtttgtt tgtttgtttt gagatggagt cttgcctctg tcgcctaggc 7320 tggagtgcag tggtgggatc tcagctcact gcaacctctg cctcctgggt tcacgccatt 7380 ctcctgcctc agcatcccgt gtagctggga ctacaggcat gcaccaccac gcccagcgaa 7440 ctttttgtat ttttagtaga gacggggttt caccgtgtta gccaggatgg tctggctcgt 7500 gatctgcccg cctcagcctc ccaaaatgct gggattacag gggtgagcca ccacgcccag 7560 ccgagtttat gttctacttg gaagattttc agccattatt tcttcaaata ctctgtctct 7620 tctggtgact gagatcttat tatatttacg ttagaatgtt agattttgta tcagagctaa 7680 cttagtatct gttctttttt ttcccccatc attttctatg tttcactttg gacatttccc 7740 tgtgagggct cttcaagttc attgatctgc ttctgcagaa tctaacctgc tgttaatctc 7800 atctactgta tatcagatat atattttttg aactttagaa gttctctttt ggcattttta 7860 atatcttcca tctatttcct ggtcatcttt gtgtttttct tttttgagac agggtcttac 7920 tctgtcaccc aggctggagt gcagtggcac agtcagagtt cactgcagcc tcaacctctt 7980 gggctcaagt gatcctccca cctcggcctc ccaagtagct gggaccacag gcacttgcaa 8040 ccacacctgg ctaatttttg tatttttagt agagacgggg tttcaccatg ttgcccaggc 8100 tggtctcaaa ctcctgcgct caaggaatcc tcccaccttg tcctcccaaa gtattgggat 8160 tacaggcctg agccaccgtg cgcaacctat gattttggtg gtggtgtttt ttgtttttct 8220 gttttttaaa tattcttgag tatatttgta agctttagat gacctgtttt aagttattta 8280 atctatcaac accattatat ctgttattac ggccactgtt tctgttgatt acattttttt 8340 tcctgcccat agggactttt tttttcatgc atagtaattt cttattgctt gacattgtga 8400 attttgcttt cttgggtacc gaacatcact gtgttctttc aaagtctatt gggcattatt 8460 ctggtcacag aaaactgagg atcagtttgc tcctctgata ctagctttta tctacatata 8520 actatatacc ttgtgttcag ttgccttatt caggggctca tttagttaac tactaaagtt 8580 atagtggttg acttctgatg gtaactcgcc agcaccctgg catgcgttct gtccactgtg 8640 ggaaggggaa catgcagatc tcccagccct gagtggtcca caatctagtc tctccttccc 8700 tgggtggctt cttctcaggc acctagagtc agtctcagca gacactggac atgtcttctg 8760 caaggatcca gagtcctcca ggcagctgct tctcccagtc tctgccctgc acttggcctc 8820 tgggagttcc tgcctgtggt tctcaacaga gactacagag ctctacaggg tcctctgccc 8880 ctgctgtagc tggaggctgt ccttacgcag tgagctgagg ccacagctag tctcactgca 8940 tgtgcttggc ggcggggaca ggagtgattc attcatcagg tagaggagga accctttact 9000 ctgggaaaat ctgtgcctgg gttggggaag gacaaatgag ccctgtgtga atactgacta 9060 ctccctggag cccacagtct ggtggagcag gtgacagcag ggacctaaat aactatcagg 9120 aagcatgagg tcccaccact gtcacctccc ccacctccag agtggctgtg ctggctccag 9180 agatgtcatc cctccatatt tgactgacag agggaggctg tgcagtccca aggctccagg 9240 tcatggtagt ttggccagga taatatggtt tgcttaaaat caacattgag ggtaatgatc 9300 gtactaatca gagcatgtgt ttaaagttct gtgttttaag cactttccat acatattaac 9360 actttcagtt cacacaacaa cctatgcagg aactgtgatt atcctgggca gttttaagga 9420 tgtgggtgac tcagagagga aagaagaggt tactcgggtt aatttttgac gagaaatatt 9480 agcaggtttt atgctcaaac ttggtgtaaa gcaaggagcc tgaatcacag gtgggtgagt 9540 cacaagacag ggaaaccccg ccaatggctc atgtccggga ggaggcaggg tccctagaat 9600 tcaatgggac aagaactgaa ataagccaaa cccctgacct cccttcttct tgttttcctt 9660 ctctctctta accatgccca tggacacccc catgagccca tttctgtggc ccaacacagc 9720 tgtgcatctc tggccacacg cccattctcc ctcaatcaga gaggcccacg gacggcacag 9780 cctcgtcctg cacagcagaa agagtgaatg gtgatgaatg gatctatatt atttcaactc 9840 tcctacattt tgtaatcata ttacaatatt aattcagcag tacctctctt gtttttactc 9900 ccctccccca ttacactgga ttcctgtctg tctgggattc tgtctgtgtg cactctttcc 9960 tctatgtcca ctactgtccc tgccaccgat ggcatttgtc acctctgcct gggcagcccc 10020 tccagactct ttgcaagttc atggactttg gggttaatga tggctgtgcc tcagctcctg 10080 tgaatggaaa ctgtgctaag gaaaggaagg gccgtgccat gttcccgata ctccacggct 10140 ccttgcatat gcggtcgcca ggcgcctaca tgccttccat gaatgaatga atgagtaacg 10200 tggattctag gaagctgcac taacccagac gttgtgtcct cagcctgctc atagagtgtg 10260 ttaaacgtga gaggtgggga gtgtggcagg caggctgagg acagaacaga ggatctgaat 10320 agagtacgga ggatcaccca agtccagagt caccaaggcc attgtcaagt tttccccggg 10380 gacatccctc atcagatcca cccattaaag atcattgttc acccagtgga gagtggacta 10440 ggtgggtgca ctcaggtgtg gcctggacag cattcgggat gggtcctagt ggttagggtg 10500 agggtcaggt tgcattatcg tgaaggaggc aagtggcagc tgaggcagat ctgagggaaa 10560 tgatgataac gcaggccggt gatgcaatgg gtttggtaag aagaggaaag aggtttgtgg 10620 tggattctag tgtttctaat ctgagacttg ggtgaggtca ttaccaaata agaaagagta 10680 aatgggcata aatggcttta agaattagga acctgaatgt gctattggag acagtatggg 10740 cacgtcattg ctcatagacc tgcagtacac aaaatgctaa aagatttcaa tctgaataga 10800 gatgaaatga aatggaaaca tggatttttt tttttttttt tgagacagtt tcactgttgc 10860 tgcccaggct ggagtgcaat ggcgcaatct cggctcactg caacctctgc ctcctgggtt 10920 caagcgattc tcctgcctca gcctcctgaa cagctgggat tacaggcgct tgccaccaca 10980 cccagctaat ttttgtattt ttagtagaga ccgggtttca ccatgttggc caggccagtc 11040 tcaaactact gacctcagga gatccaccgc cttggcctcc caaagtgctg ggattacagg 11100 catgagccac cttgcctggc tgggaacatg gatcttaagg aaagaaggaa gatcatcagg 11160 aatagaaata tgaatgcaca tataaagaat gattatttcc tcttaatttc ttgaaaatat 11220 tcactatcaa gtaatataac actttgtagg gtttgtaaca tatgaacatg cctgagacaa 11280 ctatagcaga aagaatgagt agtggagatg aatcaatctg tattatttca agtctcctac 11340 attttataat attaccatat taattctgcc atacaactca gtaatgaaaa ggaatggagt 11400 actgatgcat atgaaaatat gaccgaattt caaaataatt atgctgagtt aaagaaacca 11460 gacagaaaag catatatagt atctgattcc atctatgata tttatagcca gaaatggttt 11520 aattaaaaaa gaagaaggat cttaaatcaa cgagctaagt ttacaaatgt aggaattaga 11580 aaaagaatga accaaaccta gagttagcat tataaaggaa ataattatta gaagagaaat 11640 aaataaaaca gagaatagaa aaacagtaga ggccggatgt gatggctcac gcctataatc 11700 ccagcacttt gcgaggccaa gacaggagga ttgcttgaag ccaggagttt gagaccagcc 11760 tggatatggc aaaaccctgt ctctacaaaa aatataaaaa gcagcctggc ccgggggagc 11820 acacctgtga tcccagttac tcgggaggct gaggtgggag gatcacttga gccccggaga 11880 tgtaggttgc agtgagccaa gatcacatca ctgcactcca gcctgggcaa cagagtgaga 11940 ctctgtctca aagaaagaaa gaaaaagaaa aaagaaaaac catagagaaa atccacaaaa 12000 ccaacattga ttcttcaata ctattaatta aactgacaga attcactagt gaattctaac 12060 aagcttttaa tgaagagcta ataccactac ttctcaaact ctttcaaaaa cttgaagaga 12120 agggaacctt tcttgactct ttctgtaagg ccagcattgc tctgataccc aagcagataa 12180 agatattaca agaaaataaa gctatatccc agtatcccta actgatgcaa aaatcttcaa 12240 caaaatacta tcagagagaa ttcaacagta ccttagatgg attatacacc atgaccaagt 12300 tggatttatt tccggaatgc aagaatgttt gaacaaatga aaactgaaca atgtaataca 12360 ttgcattaat agaatgaagg gggaaaaaga cacatgatca tctgagttga tacagggaaa 12420 gcctctgata aaattcaaag ccctttcatg atgaaaacac ccagcaaact aagaatagaa 12480 gaaaacttcc acaacatcat aaaagccatg taagaaaacc ccacagctaa catcatactc 12540 agtgttgaaa gacggaaagc ttttccttta agattaagaa caacataagg atatctaccc 12600 acctttgcca ctcagcatag tactggaagt tctagccaaa acaggcaaga aaaagaaata 12660 agagcatctg gactgtaaag gaaaaagtaa aataatctgt gttttcagat gatatgatct 12720 tactggtaaa aaatccaaaa gatttcacaa aaaattaaac tgccaaaaat aaaataatat 12780 taaattttta aaattttgaa atttattgtt gttcagtaaa agacagtaca gattgcaatc 12840 tgggagattt caaaccaagt ggtaagaaac ttgccttaca gcaggtatag tacaggctat 12900 aaaggaggat gtattttgac aatttcatga ttgacttata aatttatatt ctttttaaag 12960 gcaatcagag ctgtttaagc tgatttttct atagctgctt gatttaactt cactgaacca 13020 tattatgtca tgatgaaggt gtaaaactta tattttgtgg gattttttat gattatagct 13080 aatgtttcag ggatatcagg atgtcttaag ttttggctac atggttatgg gtaattgccg 13140 tggggtatat ctaaactgtg tttttaattt ttatttagta gtactaaaat gaattcatca 13200 aagaagcgga atacaaaatc aactggaaaa gtcaattgca tttctataca ctaccaatga 13260 acaattcaaa aaaagaaatt aggaaaaaat ccatttacaa tagtatcaaa aataataaaa 13320 taggagtaaa ctcaccaagg aggtggaaga ctagtacaat gaaaactata aaacattact 13380 gaaagtaatt aaagaataca aaaataaatg gaaagatatg ccatgattat gaattataag 13440 actaattatg tcaacatttc ctaaagtgat ctatacattc aatgtaatct ctatcaaaat 13500 cccaaggaca tttttgcaga aatgaaaaaa tgtatcctaa aattcatatg gaatttctag 13560 ggaccagaat atccaaaaca atcttgaaaa tgaataaaaa tgtagtagga ttcacacttc 13620 ctgattttca aaacttccta caaagctgca gtaatcaaaa caggatggta ctgacataaa 13680 agcagataaa tcgatcagtg gaatagaata gaggagccag aaataaacac tcacatatat 13740 ggccaaatta tttttcacaa ggatgccaag actgttgaat ggaggaaagg gccgtctttt 13800 caatgaaggg ggctaggaga accggatatc cacattcaaa agaatgaagt gaaccttagc 13860 ctaacattgt atttaaaaaa tagctaaaaa caaataaaag atgtaaatgt aagtgctaaa 13920 gctatagaac tcttgaaaga aaatatagga taaaaattct gtgacattgg atttggcaat 13980 aatttcttgg atgtgacacc atggacatag gcaacaaaag aaaaaataaa cattttggac 14040 ttcttgaaaa tcagtaactc ttgtgaatca aaagatacta ttaactggat aaaaaggcaa 14100 aacccacaga atgagagaaa atattttaag ttatatatct gataagggct taatatctaa 14160 aatatataaa gaattcctac gatctaacaa aacaaaaaca acccagttaa aaatgggcaa 14220 ctgattttta taaacatttc tccaaagcaa atatacaaat ggtcaataag tatatgaaaa 14280 gatactttaa tcactaatca ttagggaact gctggtcaaa acgacagaga taccatccta 14340 tacccatcag gatgactatt ataaaaaaca cacacaggcc gggtgcggtg gctcatgcct 14400 gtaatcccca cactttggga ggccaaggca ggcggatcac gaggtcagga gattgagacc 14460 atcctggcta acatggtgag accccgtctc cactaaaaaa aaaatacaaa aaaattagcc 14520 cggcgtggtg gcaggcgcct gtagtcccag ctacttggga ggatgaggca ggagaatggc 14580 gtgaacccag gaggcggagc ttgcagtgag ctgagatggc accactgcac tccagcctgg 14640 gcgacagaac gagactctgt ctcaaaaaac aaaaacaaca cacacacaca ataagcatta 14700 gcaaatttgt agagaagttg gaaccctcgt gccctgttaa tgggaatgta aaatggtgca 14760 gccactatgg aaaacagtat gatagttcct caaaagtaaa aacaggatta gcagatgatc 14820 catcattccc acttctaggt atacgtccaa aagaattgaa agcatggttt caaacagata 14880 tttgtacacc cacgtttata gcagtattat tcacaatagc caaaaagtgg aagaaactca 14940 agttggacag atcaatagat aatgtggtat attcatacaa tggagtatta ctcagccttg 15000 aaaaggaagg aaatactggc acatgctaca caatggatga acattaaaga catgctcagt 15060 aaaatgccat tcataaaagg acaaatgaaa taggattcca cttgaggtac ctaatgtagt 15120 caaattcata aaaaccaaca gtagaatgtt ggatgccagc ggttgtaagg agggaagaat 15180 gggaagatga aataacttct gaggatggat agttgtgatt attgcacaac aacattaata 15240 aatgtagtgt cactgaacta tgtattttaa aagattaaaa gataagtttc atgttatata 15300 taatttacct tagttttaga tttaaaaaaa cagcatttat tttagtcact ataacaatta 15360 cacataaaat ggaaatattg ttgatttaaa aagccaatgc acaagctggg cacggcggct 15420 cacacctgta atcccagcac tttgggaggg tgaagcgagc agatcacctg agattgggag 15480 ttcaagatca ccctaaccaa cacggagaaa ccccatctct actaataata caaaattagc 15540 tgggcattgt gatgcatgcc tgtagtccca gctactcggg aagctgaggc aggagaatcg 15600 cttgaacctg ggaggcagag gttgtggtga gccgagattg tgccatggca ctccagcctg 15660 ggcaacaaga gtgaaaatcc atctgaaaaa aaaaaagcca atacacaatt aaaatgggat 15720 tctaaaacat actcaattaa cattaaatat acaggtaaga aggaacaggt aaaaaataga 15780 atggacaaaa attggtaaaa ttatagaact attttggcta tagtaataat tacactaact 15840 gtaaatccac caaacactat aactcaaagg tagatatggt tagaaggatg aaaaagcaag 15900 acttaactac ataatgttta taagagatgg aatttttttt tgagacagag tcttggtcta 15960 ttacccaggc tggagtgcag tggcgagatg tcagctcact gaaacctcct cctcctgggt 16020 tcaagcgatt ctcctgcctc agcctcccaa gtagctggga ttacaggcat gcatcaccat 16080 gcccggctaa tttttgtatt tttagtagag atggggtttc accatgttgg ccagtctggt 16140 ctcgaactcc tgacctcagg tgatctgccc gcctcggcct ccccaagtgc tgggattaca 16200 ggcatgaacc attgtgccca gccaagagat ggaatttaaa agcaaaatgc aggtatagta 16260 ggagcaaatg gatgaaaata gatataccat tcaagtaata agcctaagaa aactgctgtg 16320 gctatcttaa tatcatatga ggtggatttt aaggtaaaga atattataag acatgaaaag 16380 ggacctttgt agtgttaaga gagttaattc atctggtaga cataataatc ataagatata 16440 tgtcctcaat aatagagctt caaaataaat gaagcaaaaa tttacccagc actttgggag 16500 gccaaggtag gcggattcac ctgaggtcag gagttcaaga ccagcttagc caaaatagag 16560 aaacttgtct ctactaaaaa tacaaaaatc agccaggtgt ggtgtcatac acctgtaatc 16620 ccagctactg gggaggctaa ggtaggagaa tcacttgaac ccaggaggcg gaggttgcag 16680 tgagccgaga tcatgccaca gcactctagc ctgggcaaca gagtgagact ccaatctcaa 16740 aaaaaaaaaa aaaaaaaatt acagaattca gaggaaatta taatacactg ttctaagcaa 16800 ttaatggaat ggtttgacaa aaatattagt aaagtcataa aagggccagg cgcggtggct 16860 cacgcctgta atcccagcac tttgggaggc tgaggcaggt ggatcacaag gtcaggagat 16920 tgagaccatc ctggctaaca cagtgaaacc ccatctctac tgaaaataca aaaatgagcc 16980 gggcatggtg ggtggtggtg ggctcctgta gtcccagcta ctcgggaggc tgaggcagga 17040 gaatggcatg aacctgggac gcagagcttg cagtgagcca agattgcacc actgcactcc 17100 atccagcctg ggcaacagag tgagactccg tctcaaaaaa aaaaaaaaaa agtcataaaa 17160 gatctgaacc accttgactt aattgacatt tataagagga cacatgcatc tactgaaaac 17220 tcattctctt ctagtgaaga tggtaccctc actcatttta tagcccatat tctgggctat 17280 aaaataagtc taagtaaagt ctcttttaaa aaagagaact catatatgtt ctctgatctc 17340 aatgaaattc aattggaaat agataacaat gtctagaaag acctccaaat ttggatgcta 17400 agcaacacac ttataaataa tccatggttc aaaggagaaa ttaaaagcta atacaaaaat 17460 atttcaaaat ataatgaagg tttaatgcat caaaacttgt gggaagctat taatatggtt 17520 ctcttttttt tttttttgag atggagtctt gctctgttgc ccaggctaga atgcagtggc 17580 acaatcttgg ctcattgtaa cctccacctc cctggttcaa gggatcctcc tgcctcagcc 17640 tcctgagtag ctgggattac aggcatgccc caccatgccc ggctaatttt tgtattttta 17700 gtagagacag ggtttcacca tgttggtcag gctggtctca aactcctgcc ctcaaatgat 17760 cgcccgcctc ggcctcccaa aatgctggga ttacaggcgt gagccacact taacttcaca 17820 tttcataatt cctgagtctt atcaggcaaa aacaagtcct gaaaaaacaa agtaaatcta 17880 cttattatag tagggcagat aatacaaagt tgggcattaa ggtaatatcg tatttatagt 17940 tttaaagctg atgactctat aaggacagta tgtgcttcag tgaaattata aacatgaaaa 18000 ctctgctttc agttcttttg gatacatacc cagaagtggg attgctggat catctggtaa 18060 ttctactttt aattttttga ggaacaacca tactgttcct ggaccaaact gagggtcggg 18120 ctgctatttc ttgccaccca ttaatgagat gccaatgaac tgggaagaaa gagtttttat 18180 ttctgtagct ggttacaggg agaaggcctg gaaattatcg ccagaccaac tcaaaattac 18240 aaagtgtttc agagcttata tcctttctaa cctatatgtc tacatgtaag tgtgcattca 18300 tctaaagaca taagtgatta acttctttta atctataact aaggtctgag tcctgaagac 18360 cttcctgtgg agcctcagta aatttactta atctaaatgg gtccaggtgc tggggtgatt 18420 accctgctaa accatggagg tttggggagt tccttcaaac ctccaatacc cttgtttgtg 18480 gaggcctggg gagtttcttc aaaaccccca ataaaacttg tttaatccta aatgggtcct 18540 gttatgaatt cctccattat tttgtcatgc tttaaggccc aggaaaggcc taagcaaaac 18600 tcttgatggg cttttgttac attccagcct ttgtataagg gcactggctt tttttttttt 18660 ttttttaagc atttaatagt taacttaagc acttgattag tactgaaaca gttgtgatgg 18720 aggcctgcat tagtgaaacc tggcctgcta caatccccac tgtcaatttg cgcatgattt 18780 ctatcatgct tgtgtattta tttatcatga gaatcgtagg gagatggggt gtcataatct 18840 ttctggctac tttcagctga gagagggtca ttgttatggg gcaccaaatg cagtactgga 18900 gtggaggagg ttgatttgtt cccggtagca ctgtctattt taggggctta gagagagtgc 18960 ctgctgaaac acctagtttt cagttcacag ggctttaaga aagcaaagct taggtttcag 19020 tgatttccag ttagggaaaa tggagaaaaa ggaaaagaaa aaggaaaaaa ttgaaaacat 19080 tttgagactt gcagccagaa aaattagaat ttaatccaaa ctgtagaaaa taataaaaac 19140 tgaaaaacat cgaggaagac tagaatttaa caggtgtaac tataattttt gaaacataat 19200 ttttctctct tgtttcccat ttttattaaa agacaaatca tggtaggact ggtttgcttt 19260 attatacttg gcctaattac ttatataccg tgcagcaaga ataattattt tttacatagg 19320 cgttttaaat gggctttgat ggaactttgt tccatagcag gaatctgaga taagaccttt 19380 ttaaagccga gcccaaccat ggatttatac catcaaatac ctatgagttg ggtgaattcc 19440 tctcttcttg aggttccaag ataacttggg gttcctggcc tgtcagaaag tgacattctt 19500 tacttaccac aggtcagaaa ccctgtacag ggtctatgta cacaaattat gaggccagtt 19560 tccaagggct ttcttggctt cctaagtcaa gtttgattcc ttaaaggaga gcaaagtcaa 19620 agccttggta aaataaccag tttttccaat tgtgtcctgt tacaaaagaa aacagattct 19680 tactgcactt atgcaaataa ctatattgcc ataacttaag aatactcaca gtttcgaaat 19740 tctggagaaa atcaggtaga gagaaacaaa tatgctccaa attttgttca taggagtata 19800 ctgtacttaa atgttaaaag gtgttaatag ctcaaaagaa aagtttcctt gcctctgaaa 19860 agcaaaacaa aggattagca acattttaag ccgaaagtca aaaagatcac ttcagtctcc 19920 tattagttca gttcatgcag ttaattcctg tcctgtttga tattaatgaa cattttaact 19980 cttcaagagt catcaacgtt tttcctctat tttgatgtca caatctccaa agttatcaga 20040 aacctgcatt caagagcacc tgttagagct ttacagctga ttataaaacc accttctaaa 20100 gaggaccaaa acaagacaga caacaattat ttatggagga caaaaggttt tagggtagcc 20160 atagttaaag acacaattga tgacaagggt atctgttacc tctgtggcac acaataattt 20220 taacataaca attataatta ttaatgataa catacactaa gatatatcag aattatagga 20280 gtcttccata actttggaac acataccaat aatatattta tgcacataca gcccaaagaa 20340 agccaaacac catttcatgt ttgacaatgc ttcctgtata attttatatc aaataagcca 20400 catttcacct ttacattagt gtactattaa tgttaaatcc aatttttaat aaaaccttat 20460 agacacattt acccaatttt aatgtttgac cataaagtaa gagttttata gacctttcat 20520 aactctttac aatttttgtt aaacagaagg ttagtgctct aagagaaacc cattgtgctt 20580 ttattttaat gctcaattta cagaaaaact ggatgatatc cctttaattt tagccaatac 20640 atttacacac agaattgtct ttacaattac ccttccacag cttgcttaaa ctttcatttt 20700 tattttatcc aacttaaaac aatcctttaa ccttttaatc tagtaaaaaa tatccacatt 20760 ctcatgcctc cttataatct ttttaccaaa agtatatttt actttcctta cacaacttgc 20820 atgtaaactg ttttttcaat agtcttaaat acacattaca ttgttaattc ttagcaacct 20880 tttcttttgg tgaaaacctt ggtaaatttg ggattttaat tatatactag gtatggagcc 20940 tacgacctag acagaaatgc aggtaaggtc tgacttattc tagcatctag ctccatgtgt 21000 cctaggcctt acctagctgc aaagcaggca agttgtacag ctaagagtca tagtggcatt 21060 ttataaagca tttaggaggc ctaatcacct ttaaattgta caacatttct tgcataaatt 21120 tcctttcata aattctttca caacttacac agacaatctc tgacatgcct tgactttctg 21180 acttgttcta aacatccctc tctttaaaca accagttaat ttactttagg acaagaattt 21240 accatacagg agcccttctt gtataaattc tcttttcttt aaaacttttt gcatagctag 21300 gggacatggc taatttcaca tgtccccagg ccgtatctag aatttaacag tccaaaataa 21360 attgaacact ttttaagtca aagaagcatt ttatgaccta aagcatttag caaacctagt 21420 atttgacctg cataatttag accaactatt tacatttttg aagatacttt taccaataat 21480 ctttaaaatt ctccttattt ttataacttt ctgtatatct ctcttatttc ctggtttctt 21540 ttaccttgtt ttatatataa cctttaaata agctttgaat aagacaacaa ttagttaccc 21600 ttggccaggc gtggtggctc acgcgtgtaa tcccagcact ttgggaggct gaggcgggcg 21660 gatcacaagg tcaggagatc aagaccatcc tggctgacac ggtgaaaccc cgtctctact 21720 aaaaagtaca aaaaattagc caggcgtggt ggtgggcacc tgtagtccca cctactcggg 21780 aggctgaggc aggagaatgg tgtgaacctg ggaggtggag cttgcagtga gcagtaattg 21840 tgccactgca ctccagcctg ggtgacagag caagactctg tctcaaaaaa aaaaaaaaaa 21900 aagttaccct ttaaaaagga cacaatcttt agaaagaatg ttttcctacg atatattttt 21960 attagaaaat acccaaataa ttagatatct gttgtttaat ataactttag attctaaatt 22020 atgacaagtt tacttatgag tatgtatccc attacattta tctaattatt tattttaatc 22080 atttacccag attatatatg aaaactgcga tagttgtcat taaagttagg aaaccaccat 22140 tgcaaaatta tgaccgagac agtgaaaatg atctgaccta actgactcca tcttccttct 22200 aacctacaag gtattcttgt ttattaactt agtttataat ttagctttga aacaaatgtg 22260 ataacagtcc tttcccagaa caaacttcct tcatgtctgt ggactagact gcttaaggcc 22320 agaagattag aagttagggt attttggcca ggcacggtgg ctcacgcctg taatcctagc 22380 actttgggag gccgaggtgg gcggatcaga aggtcaggag atggagacca tcctggctaa 22440 catgatgaaa ccccatctct actaaaaata caaaaaataa ccaggcgcgg tggcgggcga 22500 ctgtagtccc agctactcgg gaggctgagg caggagaatg gcgtgaaccc gggaggcaga 22560 gcttgcagtg agccgagatc gcgccactgc attccagcct gggcgacaga gcgagactcc 22620 atcttaaaaa aaaaaaaaaa gagtatttta ctaaataatt caagatgtaa ctatcttcat 22680 taaaacaata ttaatgtttc atttatttaa aaattacaca tgcaaagatt attctgtttg 22740 cactgaatta tagttttgta gcctctatgc cagattttga caccttataa tatttggcag 22800 agataagtat gaaattgctt gatcaataaa tgcaaactaa aatgtatgct ggaaactctt 22860 aagacatttc taatattact ttaccaataa tttttaaaac cagcttactt attaaagatt 22920 ttaagtcaca taaacttgaa aaagcatttg actagtcttt ccttttttct gttattcaag 22980 tgcttttttc tttgagccat ttaattagac ctcttttgta tatcttcagt agtgaaacat 23040 ggtgtacaca agacaaatac ataagtgtat tatgcatgcc aatagaagta cattttatag 23100 attcgtaaga cctcattttt cagtctccct ctactgccta ggccagagta cagtggcatg 23160 atctctgctc actacaacct ctgcctccca ggtaaaagca attctcgtgc ctcagcctcc 23220 caagtagctg ggattacagg tgcctgccac catgcctggt taatttttgt atttttctta 23280 gagatggggt ttcaccatgt tggccaggct ggtctcgaac tcctgacttc aagtgatcag 23340 cccgcctcgg ccttccaaag tgctgggatt acaggcatga gacaccacgc ccggccttaa 23400 ctggatgttt gagctctggg tggagcccat actgaatcct gggttttcaa aaagggagaa 23460 ttattatgag gctagaccat gtgatgcttt tacagtgcac ttaaacaatt ttttcccaaa 23520 gacatttcta agtgtctaaa ttacactttt tctttaaaac cccagagtag cttctgttta 23580 atagctatta atgaagaaaa cagaattcag tcaactgaga agaaaaaaag ttttgctcaa 23640 aaagataagg ccctaggaga gagagaaata aaaccaaaaa cacgaaggcc ttttaaaggc 23700 cttcacgccc ccgtgcgcac acacacacat atgcacatac acattttgga tgttagcttt 23760 taattaagct gactcccaat cattgagctt caaaaaatct ttctccttcc cagaggcctc 23820 tcagcagaga tggacccaat acttcccatt ttcaagttta catggtatca aaaggaacaa 23880 gacagacaca caaacaaatg gaaacatttc agaaaaaccc aaggggaagt gcactacggc 23940 aaaacagact ctcaaaacta acgcaaaacc tgatatcaac caaagggaaa gtgggtgtat 24000 gagccagccc tgttgcttcc cttggcagta ccggataaat ggcttaacca gcccaaatgg 24060 gaaaacaata ggctcctggc ctaagatccc attgactcac cctttgagca cgtccgctcc 24120 ttatctctgt tcttccccag tagagaaagg gacgtgtaga tttgcacata aacagccctc 24180 tggagggtcc cctggggaaa cctcacctga cagctgctgg gatcctcctg aagactgtct 24240 catcgcaagc taccagccgc tgaacgcggc actgtcctta tcttctggct ggcgactttt 24300 ttgttcccag accaaactga gggtggggct gcccaataat gagatgcagg tgaatctcgc 24360 tgcccaataa gaagatgcag gtgaatctcg ctgcccaata atgagatgca ggtgaatctc 24420 actgcccaat aatgagatgc aggtgaactg gggaggaaga gagtttttat ttctgtaact 24480 ggttacaagg agaaggcctg gaaattatca ccagaccaac tcaaaattac aaagcttttc 24540 agagtttata tcccttctaa gctatatgcc tacatgtaag tgtgcattca tctaaagaca 24600 taagtgatta acttctttga atctataact aaggtctgag tcctgaagac cttcctctgg 24660 agcctcagta aatttactta atctaaatgg gtccaggtgc tggggtgatt acccttatct 24720 tgtctcctgc taaatcatgg aggtttgggg agttccttca gccctcccac acacttgttt 24780 ttggaggcct ggggagtttc ttcagacccc cagtaaaact tgtttaatcc taaatgagtc 24840 cttgttaaga atttcttcat tattttgtca tgctttaagg cccaggaaag gcctaggcaa 24900 aactcttggt ggggttttgt tacatcccag cctttatata agggcactgg ctttttttag 24960 cttttaatat ttaacttaac cactcagtca gtactgacac agttgtgatg gagggctgag 25020 tgaaacctgg cctgccacga tactgttttt cccagtgtgt gttttacatt cccaccaaca 25080 gggcacgaag gttccagttt cttcacacct caccagcact tgttattttc catgctgttg 25140 tttttaatat agtagacgtt agtggtggtg agcatctttt catgtgctta tgggccattt 25200 gcttatcttc tttggagaaa tgtctttcaa gtcctttgcc ctttttaaaa ttttttaaaa 25260 atttttattg taaattaaga aattacggcc aggcacagtg gctcatgcct gtaatctcag 25320 cactttgaga ggctgaggca ggaggactgc ttgagcccag gcgaacgttc aagaccagcc 25380 tgggcaacat ggcaactccc aataaattgt atgtatttat ggggatttat agggtacaaa 25440 gttatgttat gatttatgaa tacaatatgg aataattaaa tcagctaata tgtccaacac 25500 ctcaaatact taacattttt atggtgagaa catttgaaat ttattctttt agcaattttg 25560 aaatgtacaa tatgctgtta ttaactacat tcattgcact gtgcaacaga tctcaaaaat 25620 cttattcctc ctgtctaacc aatggtttgt acctttgatt atcatctccc cattcccccg 25680 tgcccagact ctagtaacca ccattctatt ctctgcttct gagttcagtt gttttttttt 25740 tttttttttt gacacaaaaa tttcactttt gttgcccagg ctgtcgtgca atggtgccat 25800 ctcagctcac tgcaacctcc gcctcccggg ttcaagtgat tctcctgcct tagcctcctg 25860 agtagctggg attacagatg cccaccacca cgcccagcta atttttgtat ttttaataga 25920 aacagggttt caccatgttg gccaggctgg tctcgaactc ctgacctcag gtgatccaca 25980 ccctaccttg gcctcccaaa gtgctgggat tcaggcatga gccaccgtgc ccagcctcgt 26040 tgttttcaat ttcatgtatg aaaacataca gtatttctct ttttgtgcct cacttatttc 26100 acttagcatg atgtattcca attccatcca tgttgtttca agtgacaaaa tttctatctt 26160 tttaaaggct gaatagtatt ctgtattgtc tacataccac attttcttta tccatttatc 26220 tgttggtgga cacaggttga ttgcataact tggctgttgt aaatagagct gcaatgaaca 26280 tggaagtgca gatatctcct tgatatactg atttcaaatc tttttggtaa atacccagaa 26340 gtgggattgc tggagcatat aataattcta tttttagttt tttgaggaag ctccatactg 26400 ccttctgtaa tggctgtact aatttacatt cccaccaaca gtaagcaagg gttccctttt 26460 ctccatatcc tcaccaacac ttgttatcgt gcatcttttt gataatggcc attctgatag 26520 gtatgagatg atatctcatt gtggttttaa tttgcacttc cctaatgatt cgtgatgttg 26580 agtttttttt tttcaaatat ctgttgacca tttgtgtgtc ttctactgag aaatgtctac 26640 tcaggtccct tgcccatttt gtaatcagat tattttttct ctttgaatag aattatttga 26700 gttccttata tattttagat attaacccct tatcagatgt atggtatgca aatattttct 26760 cccagtctgt agcttattgc ttcactctgt tgtttccttt gttgtgcaga aacttttttt 26820 tttttttttt gagatgaaat ttcactcttg ttgcctaggc tggagtgtaa tggcatgatc 26880 ttgactcacg gcaacctcca cctcctgggt tcaagtgatt ctcctgcctc agcctcctga 26940 gtagctggga ttaccggtgc atgccaccat gcccagctaa ttttgtattt ttagtagaga 27000 tggggtttct ccatgttgat caggctggtc ttgaactccc gacctcaggt tccgcagaaa 27060 cttcttatgt tgatataatt ccatttgtct atttttgctt ttgttttttg cactttaggg 27120 gtcaaatttt aaaaaatgtt gcccagataa atgttgtgta gttttagccc ctgtgttttc 27180 ttctagcagt ttaatagttt aaggtcatat atttaagtct ttaatccatt ttgagttgat 27240 ttttgtatat ggtgtaagat aagggtccag tttcattctt gtgcatatgg atatccagct 27300 ttcctaacac catttattgt ggagactttt ttttcccact gtgtattctt ggcacttttg 27360 gcaaaaatca attgaccata gctatgtgga ttcatttata ggctctgtat tttgttccat 27420 tggtcaatat gtccattttt atacccgtgc catgctgttt taattattat tgctttgtag 27480 tatagtttga aatcaggtag tgtgatgcct ccagcattgt actttttgat catgattgcc 27540 ttggctattt gtgttttttt tttttttttt ttatggttgc atatgaattt taggattgtt 27600 ttctctattt ctatgaaaaa tgatattgga attttgatag tgattacatt gagcctatag 27660 attgctttgg atagtatgga cattttaaca atattagttc ttccaagtca tgaacattta 27720 ttttcatgca tttgtgtctc tttccgtttt atttgtctct tctgttttgt tcattagtgt 27780 tttacggttt ttaacataca ggtctttcac ttccttagtt aaatttacta attttttttt 27840 gtcattgctc ttaataggtt tgttttctta atgtctgttt catatagttc attattaata 27900 tatagaaatg ctactgattt tcatatgttg attttgtatc ccacaacctt actgaatttg 27960 tttacaaatt tctaacagtt ttttggtgga gtcttcaggg ttttctatac agaagatcat 28020 gtcatcggca aatagacaat tttacttctt ccttttctat ttgaatacct aataattctt 28080 ttctttttct tgcctaattg ctctggctag gacttccagt accatgttga aaagaggtgg 28140 tgagagtgag catccttgtg ttgttcctga tattaaagga aaagctttca gcttttcact 28200 gctgagtatg atattagctg taagcttgtc atataaggct ttttttgtgt tgatacattc 28260 cctttacacc taatttgatt agagttttta tcatgaaaga atgttgtgtt ttgtcaaatg 28320 ctttttctac atctaatgag gtgatcatat tgtttttgtc ctgcattttg ttaatatggt 28380 atatcacatt tattgatttt catatgttga accatctttg catcccagga acaaattcca 28440 ttttatcatg gtcaatgatt cttttaatga gctattgaat ttggtctact ggtattttat 28500 tgaagatttt tgcatctgtg tttattagag atattggcct ataattttct tttcttacag 28560 tgttctattc tggctttggt atcaaggtaa tgcaagcctt gtaaaataag tttggaagta 28620 gtccctcctc tgtaatttat ttgggaaagt ttagaaagga ttggttttag ttcttgttta 28680 aatgttttgc tgaattcagc agtgaagcct tctgggtcct gggtgtttct ttgataggag 28740 acttttcatt actgattcaa tatccttaat cattattggt ctgttcggat tttccatttc 28800 ttcatgattc agtattggta ggttgtatgt gtctagaaat ttatccattt cttccgggtg 28860 gttcaatcct ttggcatata attgttcata atattttcat atgatccttt gcatttctgt 28920 ggtatgcatt gtaatgtgtc tcattttttt ttttatttga gacagagtct ccctctgttg 28980 cccaggctgg agtgcagtgt gacaatctca gcttactgcc actttcacct cccaggttca 29040 agtgattttt gtgccccagc cacccaagta gctgggatta cagatgcaca cctccatgcc 29100 tggctttttt tttttttttt tttttttgta ttttattagg gacgaggttt tgccatgttg 29160 gccaggctgg tctccaactc ctggcctcaa gtgatccatc cgtctcggcc tcccaaaatg 29220 ctgggattat aggcatgagc cactgcacct ggcctcctca ttcatttttg atttaattta 29280 tttgtcttct ttcttttttc ttagttagtc tagttaaagt ttagtgattt catttatttt 29340 ttcaaaaaac taacagaatt ttgataatct tttgtatttt tttcagtctc tatttatttt 29400 tgctctgatt tttattattt cttttgttct gctaactgtg ggcttagtgt atcttttctt 29460 ctatttcctt gaggtacaac attaagtctt gtatttgaga tctttcttct tttttgatgt 29520 aggcgtttat tgccatttcc tcttaaaact gcttttgctg catcccatac atttggttat 29580 gttatgtttc catttcattt tctaatatac tcttaaaatt cccttttgat ttcctctttg 29640 acacattggc tattcaggag cttgttacca ttcaagttct ttgttcattt cttaatcaca 29700 ttgttggctt tttgttgttg ttgttgagtt ggagtttttt atatatttta gatattaacc 29760 ttttatcaga tatacaacta gcaaatgttt tcctcttcct gtgggttgcc ccttcactgt 29820 tgatcatcat tggatgcaca aaagttttta atttttacat agtgcaattt atctactttt 29880 tttcctatat tgcttgtgtt ttggggatca cattcaagaa atcattgcca aatccaaggt 29940 caggaagaat agttcctatg ttttcttcta agttttaggg ttttcacttt tatgttagat 30000 tttggatcca ttttgagtta atttttgtat acgtgtaagt taaaggtccg aggtcattgt 30060 tttgtgatga gtcaatgtct agatttccca agaccatttt taaaaagatt gtcctctcaa 30120 ttaaatggtc tttatacctt tgccaaaaat tacttgatca tatacagtca tgcaccacat 30180 aacaacattt ctgtcaacaa cagactgcat atgtgatggt ggctccatgc aattatgtaa 30240 catgctacac aggtttgtag cctaggagca aaaggctata ccatataggc caggtgtgtc 30300 ataggataca ccatctaggt ttgtgtaagt acactcttct gatgttcaca caacacaatt 30360 gcctaatgac cctttgctca gaacaatgtt gagcaataca tggttgtacg tgcaagttca 30420 tttctgggct ctctggtcta tatgtcaggc accttttaaa tcagaagttc actatttaat 30480 gtttgatcct gtatcccaat tttttaagtt tgctatatta taacccccat ttataaaaat 30540 gtgtgtctgt gtgtatgtct gtgtgagaga gaataagaga aagagagaaa gagagaatag 30600 gcatacctat ggaaaaatag tggaactaaa tgagacaaaa tattaatgga tgctatcttt 30660 agctgagaat atcacgtgtg gtctgtgtat tcttgtaaaa actttccttg cccacatttt 30720 ctggaatgaa catgtttaga agagttttgc aggtgtatgt tacttggcct tccctgaaat 30780 atgaagggac aaacaaacac taaaggatgt ttgagaggtg agagctgcaa gaaagatgag 30840 ggttctgttt agcttgggtg cctgggctca agagaatgtg agtggatcct gggaggggtg 30900 aggtctggaa gccactcatg cccatccctg ctttgtcccc acaggtctca gctgagtctg 30960 ctctgatcac ccaacaagac ctagctcccc agcagagagc ggccccacaa caaaagaggt 31020 ccagcccctc agagggattg tgtccacctg gtatgttcaa gatgggtctc taatccttgc 31080 ccctcctccc cttgtctcca tgagcttcca gtctgtttcc tttgcacttc cttgttcttt 31140 attccacaga gaggcattgg gtgcctccag ttcaaggctc tgtccttctg gagccttcct 31200 gctaggatgg tatcaagaca cacaaatgaa tgagacagcc aaagaaactg ataggaacct 31260 tgagagagaa ttgagtggga cagagatggg gctggtgagg cctccaggca atggtgactt 31320 tgggctgaca tccggaggag ggcagggcca gaggttcaga gagccaggaa gagtgctcct 31380 aggagggttc cactggaaca attgccaggg ggcaagagtt ggagaagatg gagcaacagc 31440 agggggctgc tgtggggagt ggagggttag gaagttagag agacacgtgg ggtcagatcc 31500 cacacagatg aagctggatt ttatttcatg agtgatggat gtccctgaga agttttcagc 31560 agagggccac cagcatcgga tgtacatctt gagtgcccac tcctggactg aaccggagca 31620 agacaggaag caggtggagg gccttgagtg tgaggcgctc ccctgggatg ttatgtggtg 31680 tcccgtaagg tcatttgagc ccccagagat gcagcaggaa cctggcctga agtgtgcttg 31740 actgttgtgt tcgcctcgca cttcttcccc cttttccccc atgtgtatga gttaggaatt 31800 gattgctgca tgaaggtttc cagggcaggc aagtgtggca agcagtggct tttaaaatcc 31860 atttacaaag ttgcatttct tttccatgac taagggccac aggaaaggct tgcctgaggg 31920 caaaccctca cattgcacat gtgggcttgc caggagcaga gcatggagaa ggaagaaccc 31980 agcgtgaagc agacacaaac tcatctgtaa atgctcctat tgctgtggtc cagggtcaag 32040 accaggaagc aggacgggaa taggaaggac tcaagacata tttggggtgt ggatggatga 32100 cgtgtgggga atgaggacaa tcgaggcacc aaattcaact gctcagggta acttggcctc 32160 tgaggggaca gtgtgtggca gggctagcag tacacatttg gggaccctag cacataggtg 32220 atgcttgaag ccgctgtctt gagtgtgtcc acctggaaga agttgtaaat actgaggagg 32280 ggcacaactg agcccatgag gatttgaagt tggagacgat aggccaggga gacaggactg 32340 caatgggctg agcaggagca gttggagaac ttccatccta gaggagagat ggcccttcca 32400 gccacaggga gcaggccata gcaagtgtca aggactgaga tgtggaaact cctcgaaatg 32460 tgcatttctc ttcctgtgaa tgaggtcaag aatctgttca tgacacagac actgtttgta 32520 cactggttct cctaggtttt cttcactcct agtaagaggt taggtttttt tttttttttt 32580 ttttaaatca ttgagtcaca tgaattctta cagattaggg aaattataca ttgattgatt 32640 gattgattga ctgattgaga taggatttca ctctgttgcc caggctggag tgcggtggca 32700 ggatcatagc tcactgtagc ctcaaccact tgggctcaag cgatcctctc acctcggcct 32760 tccaaagtgt tgggattaca ggcgtgagcc actgcgctgg gtccaaaatt ctaataaaaa 32820 ttcccatata acgccgggcg cagtgactca cacctgtaat cccagcactt cgagaggcca 32880 aggtgggcaa atcacttgag gccaggagtt tgacaccagc ctgaccaaca tggcgaaacc 32940 ctgtttctac taaaaataca aacattagct gggtatagtg gcgtgcctgt agtcccagct 33000 acttgggagg ctgaggcagg agaatcgctt gaacccggga ggcagaggtt gcagtgagct 33060 gagatcacgc cattgcactt cagcctgggt gacagagtga gaccctgtct caaaaaaaaa 33120 aaacaacaaa aaaaaaatta tcatatatct ttgcagtcat tttgtggttt cctattttgt 33180 aattaagtca ttgagccaca tggacttcat tttgtagtaa gaggagagtg aggaagacac 33240 attattattt gacagccacc tttttggttg ccccaacact attattaaat aatcacgttt 33300 ttatcagtga catgaatcac tatgattatg tatgatactt acattattaa gtaaggtttg 33360 tgtaatttgg attttttaga atgtctttca atattaataa aaataattca ggaatcttgt 33420 ggctagcata taggtgatta tggtctattt tttgcgtttg tttttactca ttctgccact 33480 ctctgccttt taattgcaga gtttaaacta ttttcaatta acatagttat tgacaagaaa 33540 agatttgttt ctgctcttca gttatttgtt ttctttatgt cttatatata ttttgttcct 33600 cccttatcac cttttgaaaa aactttagtt tatttcttgg catgtaccat tttcactcac 33660 ttcttttctt ttctgcatat tttaaaatat attttctgtt tttcttaaat atatattttg 33720 tgtatatata tttaataaat atatattttg tatatatata tttaataaat atatattttg 33780 tatatatatt taataaatat atattttgta tatatattta ttaaatatat attttgtata 33840 tatttaataa atatatattt tgtatatata tttattaaat atatattata tatatttaat 33900 aaatatatat tatatatata tttaataaat atatatttaa atatatactt agtatatatc 33960 ttaaagatac atatcttaaa tatatatata gatatatata tattttttga gacagggtct 34020 gctctgtcac ccaggctgga gtgcagtggt gcgatctcag ctcactgcag cctatggctg 34080 ctgggtttaa gcgattttcc tgcctcagcc tcctgagtac agggagtagc caccatgcct 34140 ggataatttt tgatttttag cagagacagg gttttaccat gttggtcagg ctgtctcaaa 34200 ctcctgacct caagtgatcc acctgcctcg gcctcccaaa gtgttgggat tacaggtatg 34260 agccacgcac ctagcctaaa acttattttc ttactggttt ccttgaagat tacaattacc 34320 ttcttaagta tctaaacagg tagttttata ataccggcag aatttcattg caatccaaat 34380 actgtgctcc tgtaccactc catctctcca gctttctatt gttgctgtca tagatcacat 34440 ccttgcacgt tgtgtgacca ctgacgtcga tcttaaggac atgtatgtgt atggagcaag 34500 gttgacttgt gatggttgat tttatgtgtc aacttggtta cccagatact tggccaaata 34560 ttatcctaga tgtttctgtg aaggtgtgtt tgttgttgtt gttttgttgt tggttttaga 34620 tgggattaac atttaaatca gtgggctttg agtcaagcag attaccccct taatgttggc 34680 aggtcccatc taatcagttg aaagcctcaa tagaaaaaag actgacctcc accaagaaag 34740 agggtgttct gccagcaggc agccttcaga cctgagctgt gactcttctc tgctggccta 34800 tcctgtacct tttgaatttg ccagcctcca cagttatgtg aaccaattcc ttaagataaa 34860 tctttatctc tctagagcag gggcccctga cccccaggcc atggaccagt actggtccgt 34920 ggcctgttag gaaccaggcc acacagcagg aggtgggctg tagatgagtg agcattactg 34980 cccgagctct gcatgccgtc aaatcagcgg cagcattaga cttcatagga gcgtgaaccc 35040 tattgtgaac tccacatttg agagatctag gttgcgcact ccttatgaga atctaatgcc 35100 tgatgatctg tcactgtctc ccatcacccc cagataggac catctagttg caggaaaata 35160 aactcagggc ttccactgat tctacgttat agtgagttgt ataattattt cattatatgt 35220 taccatataa tagtgataga aataaagtgc acaataaatg taacatgctt gaatcatcct 35280 gaaaccatcc ccatgccccc aactccagtc cgtggaaaaa ttgtctttca ggaaaccagt 35340 ccctggtggc aaaaatgttg gagacccctg ctctagagag ccctgactaa tacagaattt 35400 ttaaagattt gaaattcttt taaaccatac ttgatctcca agtaatggaa ataataagat 35460 tatatttcca cctaacataa tacagctatc ctgtatacaa ctgaaaacgc actaaccctt 35520 tctccagaag aggatgcaaa gttcttgagt ggtgtttact cctttccttg ataccctgga 35580 acataaatac tataaagtga acaatactta aatactatga tataaattca aaatatcttg 35640 tgttacataa caaggggata agagaaggaa gaaaacacag atattcgctt aacatatatt 35700 tacacataaa cacacacaca taacacaata aggaagaaat acttataatg attacagtcc 35760 ttatttccat agctggtcat gtcattgtag ctggtattta taagaagctt ctttcgctgt 35820 gcattctgta ttccctgtgc cctcactaag cacctcagct ggtcatggct ctgtgcctgg 35880 tagagtgaac taacctttat tcctgaaggg tctgagctat aagtggtcct gctttaatag 35940 ggtcgtggta gttttccatt gactttactc acagggcatg gtaatactaa gagatgccct 36000 aaggaatctc ctgtattcta gacatcctct tccttacgtc cattgtggaa taacagtcca 36060 attttccctt caatttcccc tttgtgttca gaatcagtca atccagccag cagggtttgt 36120 gtaactggtt ttcgcctgtt gattcagagg catgaggaac ccaaagtggc caagtggcag 36180 tcttcaagtt acacagaatc actgttgtgt ctcctcatgg aatcattcct ccctctgaaa 36240 ctcagagctc tagcaaagca taaagcagca aaaattttga taacaggcca ctaagggtaa 36300 tgtggagtgg ggccattcct gcttccaccc ctagattcct ggacacatga atcctagcaa 36360 tggaagaagc aaccgcatgt attggaggat aattcagagc atagacagtc tcctggagaa 36420 ccttgttgca gcccttcaag gtactgccac ccagctgaca ttgtaaatga gttttcaaaa 36480 agccatatcc caccatctta ccaagccagc agttttgaga tggtggggaa catggtaaga 36540 ccagtaattc catgagcaca ggcccattat agtgggcgct tcatttgcca tcaagtgagt 36600 ccctcaatca gaagcaatgc tgtgtgaata ccatgactgt ggataaggca ttctgtgagt 36660 ccacagagga tagttttgac agaagcattg catgcaggga aggcaagtct atgtgcaaaa 36720 taagcttctc ttccagtaaa aatgctgccc cctccatgat agaaatggtt cagtgtaata 36780 atcaacctgc caccaggtag ctggcagact gaccctctga atggtgctat atcagagact 36840 cagtgttgga ctctgctgcc tatagattgg gcactcagta gcagctgtag ccaggttggc 36900 cttggtgagg gaagtctgta ttgttaagcc catacataac ctccatccct gccaccatgc 36960 acactttgtt catgagccca ttgagtgatg acaaggatgg ctgggaaaga agctgactgg 37020 tagtcacaga acaggtcatc ctatccacct gattattaaa atccttccct gctaagatca 37080 ctttttgtga agatatttgt gtcacatggg gcacaaatat cttcatggtt tttttaccca 37140 ttgagaaagg tctatccaca cacctcttcc ccagacttcc ttgttatcag ttttccttca 37200 gagcctctga ccctccagcc aaatcattga ccacagctca tgaatcagta tataactaca 37260 tgtctagcca ttcttccctc aagcaaaatg aacaaccagg tgtactgctc agagttctgc 37320 ccagtggcag gatctctttt ttttgagacg gagtttcgct attgttgccc gggctagagt 37380 gcaatggggc gacctcggct cactacaacc tctgcctccc gggttcaagt gattcccctg 37440 cctcagcctc ccaagtaact gggattacag gcatgtgcca ccatgctcgg taattttgta 37500 tttttagtag agacgaggtt tcaccatgtt ggtcaggcca gtctcgaact cctgacctca 37560 ggtgatccac tcacctcggc ctcccaaagt gctgggatta caggtgtgag ccaccacacc 37620 cggcctagcg gatttctttt caccactgtc cttcagggac gtcccagaca gtggatgtga 37680 tgctgcaaac atccacttct aagggttacc tgtatgtggt gcagaaccat ctgtaaacct 37740 tcttctggca actgaccata gggaattcct catgaggcca taagtgcagg ccaggcaaaa 37800 gaaagtaata ttgcaggagt ggggatcatg ggcacttggg ccacttcttc atgtaacttt 37860 cttgtgcctt cagggcctat ttaagcccaa ttttgtatat ataccaatta catttgaaaa 37920 tggaaatgga aactttaggc tgtatgtgcc caaacttatg gcttggtagg caaaataaca 37980 ctcagttcac gatgagcagt caggtcgtag agtaatttgg tggcctatgg ttaaccattc 38040 agtctgcact aaggcccaga aacaagccaa gagctgtttc tcaaaaggag agtagttatc 38100 tgcagaggat ggcaagtctt tgctccaaaa cctaagggcc tgtgctgtgg ttgacctaga 38160 gtgggctact aaaggttcaa aacagcattg ctgtctgcca ccaatacttc aagcaccgtt 38220 gggtctgctg ggtcgtatgg cccaagtgac agaaaaatgt ctacggcagc ctggacctgt 38280 tgcagagcct tttcttgttc tgagcaccac tcaaaactag cacattttta ggtgacttga 38340 taaataggcc agagaaacac acccaaatga ggaatatgtt gccaccaaaa tcaaaataag 38400 cacactaggc attgtgtcat tttcttggtt gtagggaggt gggggtggca gatacaacaa 38460 tttatctttt atcttagaat atcttagaag agaaggaata tcttatgtgc cacatcattc 38520 aacaactagg aatttgtttc ccagttgttg tccttctact gaggtaaaag gcccttgaaa 38580 ttttgtcaga tttatttccc accccctgac atgcaaatgt cttaccatta agtctagaat 38640 agttgctact tcttgctcgt gaggttcaat cagtataatg tcatcagtat aatggatcgt 38700 cttgtgtgtt atcttgtgga agggaaaggc catcaatatc cctgcaggcc agatgtggtg 38760 gctcgcgcct gtaatcccag cagtttgaga ggccaaggtg gctgggtcac ttgagaccag 38820 gagttctaga ccagcctggc caacatggtg aaacctcatc tctactaaaa atacaaaaat 38880 tagttggatg tggtggcaca catgggtaat cccagctact tgggaggctg aggcatgaga 38940 atcgcttgaa cccaggaggt gcaggttgca gtgagctgag atcatgccac tgcactccag 39000 cctgagagac agagcaagac tctgtttaat taaaaaaaaa aaaatacctg caaactaaat 39060 tatgacatag ggctgcgagt tgatgcatcc cggagacagg atagtgaggg tatattgctg 39120 gccttgccaa ctgaaagcaa actgcttctg ggagtcttta ttgacaggta tgaccaacaa 39180 agcatttgcc agttcaacac ctgcatacca gggtaccagg gatgtggcga tttgctcaaa 39240 caatgaaacc atatctggga cagttataac tggaatcacc acctggttaa gcgtatgata 39300 atccactgtc attcaccaag atccatctgt ctttggcaca ggccaaatag tcaagttcaa 39360 tgggcatgtg atgggaatca ccacagatgc atcctggatg gtggtaatga tctctgcaat 39420 ccctccagga atgttgtatt gcttttgttt ttttgtgctt tacaggcagg gtatcactct 39480 gtcacccagg ctggagtgca gtggcacaat catagcacac tgcagcttga actcctgggc 39540 tcaggcaatc ctcctgcctc agcttcttga gcagctaaga ctacaggcat gtactgtcat 39600 acctggataa ttttgtatgt gtgtgtacag atggagtctc actgtgttgc ccaggctggt 39660 cttaaacccc tggcctcaag taatcctcct gccctgacct cccaatgtgc tggaattaca 39720 gacatgagcc accatgccca tctggtattg cttttgattt actatttttt ttaagtaaat 39780 gcaaatctgg tggcttccac ctggtctttt ccaccataat agtcttcact tcacatgtca 39840 gggaatgaag gtggggattg tgccagctgc tgagtatgtc tattccaatt acacatacta 39900 aaatgaggaa atcagacagg atgggtgtgg ggacccactg gcccctttct gagatggact 39960 tgagcttagt ttgagtaatg acaacataac ttcaatggta tgcaaacact gtgctcctgt 40020 acttctccgt ctttcctcct ccatcttgtt gttatagatc acatccttgt acattgtgtg 40080 cccattaaca tcaatttgta attattgttt tctgcatttg ctctttaaat catataagta 40140 aataagagga tttacaaacc aaatgtacca taatactgtg ctacagactg aattgtgtcc 40200 ccaaaatcat atgttgaagc attaccatcc aatgagatgg tatttggaga tggtgccttt 40260 gggaagtaat tgggtttaga tgaggtcatg agggtggggc cctcatgatg ggattagtgc 40320 ctttttaaga aaagacccag acaacttgct ctctctcgct tgctcgctct ctctctcccc 40380 ccctcttctg gtgtgtgcaa ggaagaggtt acgcaaatgc acagcaagat ggtggccatc 40440 tctagaacta tgataaataa atgtctattg tttaagccac ttggtctatg gtattttatt 40500 atagcagcct aagtagctgc gtaccagcat ttatatttac ctaaatagtt accttttcca 40560 gggttctttt tttttttttt tttttttttt tttttttttt ttgagacgga gtctcgctgt 40620 cgcccaggct ggagtgcagt ggcgtaatct cggctcactg caggctccgg cccctgggtt 40680 tcacgccatt ctcctgcctc agcctcccga gtagctggga ctacaggcgc ccgccacctc 40740 gcccggctaa tttttttttg tatttttagt agagacgggg tttcaccgtg ttagccagga 40800 tggtctcgat ctcctgacct cgtgatccgc ccgcctcggc ctcccagagt gctgggatta 40860 caggcgtgag ccaccgcacc cggcctccag tgttctttat ctcttcgtat gcctttgagc 40920 tattatctaa tgtcattaca ttacctccta aaggattcct tttagcattt cacagggcag 40980 atctactagt aatgtgctcc attacctttc atttatctaa gaaggtctta atttcttctt 41040 cattcttgaa tgataatgtt cctggatatc aaattcttgg ttgcaggatt ttgtatgctt 41100 gtgtttttgt ttcttggcac tttaaatatg ttacccactc ccttctgggc tctatggttc 41160 ctggtgagaa attagctaat aaccttattg aggttccctt gtacatactg agtgggccac 41220 ttgctacttt caggattttc tgttggtgtt gggcttttgt ccatttgact ataatgtgtc 41280 tcagtgtagt tctcttttaa cttatcctgc ttggagatca ttgagtttct tggatgtgca 41340 gacaaatgtt ttttaaaagt cttgcacctc cttgttaaat atcattccta aatgttttat 41400 tcatttttat gtcattgtca atgaaattgt tttcttaatt tcctttttgg attgttcttt 41460 gctactgcaa aacttttacg ctgaaaacta tcaaacattg ctgtaagaaa ttttaaaaaa 41520 gcaaaataaa caggaagata ttccatgttc atagatcaaa atggtgttaa attacccaaa 41580 gcaatataca gattcaatga aatccctacc aaaatctcag tggtgttatt ttaaaaatgg 41640 aagaacttat attcaaagtc gtatggaatt aaaaagactt attgaccaaa aacaatctgg 41700 taaaagaaaa gcagagttgg cgggactcac actttccaat tttgaaacat atcctcattc 41760 cagggcagct ttagtcccct tttctttgga tcattctttg actctataga gattcctccc 41820 gttttcttcc catggctgat ggtgtgagct ttaattttga aggcttttcc cattgttgta 41880 tgacttctgc tcctggtgta tcttccactg gctaggagct cattcagaac aggtattagg 41940 acattcttct gtgcatttta aaggtctaag atggcactgt ctaatatagt agtccctagg 42000 cccatgtgat tgccaatcac ttgaaatatg tgaggcaggt ggatcacgag gtctggagtt 42060 cgagaacagc ctggccaaga tggtgaaacc ccgtctctac taaaaacaca aaaattagcc 42120 gggtgcggtg gtgggtgcct gtaatcccag ttactcggga ggctgaggca ggagaatcac 42180 ttgaacccag gaggcagagg ttgcagtgag ccgagatcgc tgcactctag cctgggcaac 42240 agagcaagac tccgtctcaa aaaaaaaaaa aaaaatgcta ctgcaaattg agatgtgcca 42300 tgagttaaaa tatacgcagg atttgaagac gtactgtgaa aaaaatgctg taaaatatct 42360 caatgtttta tgtggattac atatttaagt gatattatct ggggtacatt aaattaaaat 42420 gcattattaa cattaatttc accccttctc acctttttta atgtgctgag tgtggattta 42480 aatttcatat gtgggctggg cacagtggct gacacctgta ttcctagcac cttgggagtc 42540 caaggagagt gaatcacttg agcccaggag tttgagacca gcctaggcaa catggtgaaa 42600 cctcgtctct acaaaaaaaa agtacactaa aaattaaccc ggtgtggtgg tgtgcacctg 42660 tagtcccagc tatttgtggg tcggggggag agggagggtc cgggaggtcg agggtgcagt 42720 gagctgagat cacaccactg cactccagcc tgggctatag agcaagaccc tgtctaaata 42780 aataaataaa taaataaata aataaataaa taggccgggt gcagtggctc acgcctgtaa 42840 tcccagcact ttgggaggcc taggcaggca gatcatgagg tcaggagatc gagactagcc 42900 tggccaatac ggtgaaaccc tgtctctact aaaaaaatac aaaaattagc caggtgtggt 42960 agtgtgtgcc tgtaatccca gctactcagg aggctgagcc aggagaatct cttgaaccca 43020 ggaggcggag gttgcagtga gccgagatca cgccactgca ctccagcctg ggtgacagag 43080 tgagactacg tctcaaaaat aaaaaataaa ataaataaat gtgtggctta tatttctttt 43140 ggcagtgctg gtttaaggtg tgtaaatgca gaattgatga actgaccaag ctaggtagag 43200 gagatttccc tcttttggtt ccacacatcc ctgaaagagg agtcccccag ccaccactgc 43260 cagcttctgg gaatcctgtg gcatttcatt caccggcttt tctctcccct cccaggacac 43320 catatctcag aagacggtag agattgcatc tcctgcaaat atggacagga ctatagcact 43380 cactggaatg acctcctttt ctgcttgcgc tgcaccaggt gtgattcagg tacagaacat 43440 atggacccca tgcctaaagg tggaatgcgg ggtgatgaca taaaagttgt agctaaaatg 43500 ggatcaggag acctagattc tggtccacct tggtcttcat cataccatgt tccatgattt 43560 tgtctttgag ctttttaata aataaaacag gcccggcaca gtggctcatg cctgtaatct 43620 caacactttg ggaggcatca cttgagccca ggagtttgaa accatcctgg gcaacatgag 43680 aaaccccgtc tctacaaaaa tataaacatt agccgggcat ggtggcgcgt gcctgtattt 43740 ccagctactt aggaagctga ggcagaagga tctcttgagc ccaggaggcc gaggttgcag 43800 ggagccgaga ttgtgccact gcattccagc ccaggcaaca gagcaaaacc ctgtctcaat 43860 aattaattaa aataataata atacagaaat tatttgtata atgtatgcta catggtaagg 43920 aaatctttta aactgtcagc tgcaaggggg tggggccatg agccaggcca agtggacagg 43980 gctggatctc agcagtggca caggtctgct ttggggccag gctctctccc ctgggctctg 44040 tgctcctggc aggtgctcgg cctcactcac ccttcaggtt ctcaggcctc tccctcctcc 44100 ccagcaggct gggccttggg gaagtccccc aagggctcct ctccttgcag tctctcaggt 44160 gatcccttgc acttcccttg ctactggcca tgcaatctaa acgatgcttg tcccctaaac 44220 ggtgctttcc cctaatctaa tgtaataaat aatgaactgt ggtccttttg tatgactcaa 44280 cgagtgttag tgacagctga agggtgggta tcctgaatga gccatgagtg tgctggtgca 44340 gaaactggcc ctcagaactc cttggcaaac tgagttgagc tgagtagcag ggtcttgggg 44400 tggggaggaa gggtcaaggg acacatcagg aaaacacatt cccaaaacct tatgctctgt 44460 cgtcaggtga agtggagcta agtccctgca ccacgaccag aaacacagtg tgtcagtgcg 44520 aagaaggcac cttccgggaa gaagattctc ctgagatgtg ccggaagtgc cgcacagggt 44580 gagacaggag ccgggggctc ccagtagctc catggaaccc caaaagaccc aagtctcctt 44640 gtacccctgt ctctcccctg acagcacccg caaggggcat ccttgaggct gtggctgccc 44700 ctcctggtcc ctctgcgtgt caccacccct gccccctgca gcagcctctt tccacccctc 44760 cccagcacga gtccccttga ccaggctgac ttgttcactg accacagaag gccatgactt 44820 ggggcccatg ataattttag gggcccatga aatgatttaa tttctcttga aataagaaga 44880 atgagtagaa tgcagccagg catatattca tctttatacc aattcagcaa taaaatgtat 44940 tttttaatat ttttatgcat gcaggggccc ataaagacaa aagtgcccat ggcccacaaa 45000 aggcataata aggccatggg tggagctcct tcaagttccc atgaggacct gagcccaccc 45060 agccggcctc acccctggcc cctgatccct cagtaagacc tgtcttttcc ctatttgggt 45120 tttaggggcc aagagtaatt tgctcttctc tggcccccct agtatttgct gtgattgggg 45180 gaaatgggca gacagctggg gacaagagct cacttttgtg gttgactgga agaccggact 45240 catcttgtgg ccacacgggc ttgtgacctt cccctggagt gtgattgctc ctaacgcagg 45300 cctcccctgc agcccaggga agctcagtgt gtgcccagca cagaaggctc ctggaactgc 45360 agctctgacc ccagagcagg gaggccgagg ggctgaagtg cgcatgctca gacccttccc 45420 cagcctcaag aagggagcac agggggaccc actgctgaca cgaggagact gtccttcccc 45480 tgacaccttc tcagggacac tggggaggga gggtggctcc tctttcatcc cacctggcca 45540 gctttccatc aagagtcccc cctctccctc tgtgtgtgta cccaggtgtc ccagagggat 45600 ggtcaaggtc ggtgattgta caccctggag tgacatcgaa tgtgtccaca aagaatcagg 45660 tacaaagcac agtggggaag tcccagctgt ggaggagacg gtgacctcca gcccagggac 45720 tcctgcctct ccctgttctc tctcaggcat catcatagga gtcacagttg cagccgtagt 45780 cttgattgtg gctgtgtttg tttgcaagtc tttactgtgg aagaaagtcc ttccttacct 45840 gaaaggcatc tgctcaggta ggtgctggct gagggcgggg gcacagggca ctctctgccc 45900 tgccccctcc caccctattc ccacagacag aaacgcctgc ccctgcccca agtctaagtg 45960 cctccagcct ggctctatcc tcctcctcgt ggtcaccccc atccccacat cccgtgcacc 46020 ccccaggacc ctggtctctt cagtccctct cccaggtctg ggggtcccca tatctcccag 46080 ccaagtccag gagggcaggg ccagttcctc ccatcttcag gcccagccag gcagggggca 46140 gtcggctcct caactgggtg acaagggtga ggatgagaag tggtcgtggg attttttcag 46200 ccttggtcag agcagaacca gagattttcc aagtgtttgt ttttactcta gttccccttc 46260 tcatccccct tcctcagggt gtctctgagt tgtaaggccc cattctgtcc ccagccccag 46320 ggctccttgt ccagtgtccc agcccccagc ccagccctgc gccccactgt cctctgggag 46380 gggggtgctt catgggcccc tcccttcctg ctaaggagac tgcttctttt ttaggtggtg 46440 gtggggaccc tgagcgtgtg gacagagtga gttgatttct ccaggagctg ggggctcagg 46500 ggttcaggaa ctgcttcctg ggacagcaga acctgggtgg gtgggtcccc attgtcctca 46560 tggctgccct gactctctga agtggcctgg gtgctctggg ctgactgtgg gggacacatg 46620 gccattttga gcaccacata ggctggtgag ccctgctgca gcccaggtga catcctcacc 46680 ccacagcctg caccctaggg atggggtgtc tgcctgagca cagcactggg ggcctggccc 46740 cagcagcggg tcctggatgt gctgagtctg ggctgcctgc ggtgacctca ctgagagggg 46800 gtggggatgt caggtgcagc tgcatactga ggaccctgca gcgagcccta ggtgtggact 46860 cctgagtcgg ctttttgcct tcccaatgtc tttttccaga gctcacaacg acctggggct 46920 gaggacaatg tcctcaatga gatcgtgagt atcttgcagc ccacccaggt ccctgagcag 46980 gaaatggaag tccaggagcc agcagagcca acaggtgtca acatgttgtc ccccggggag 47040 tcagagcatc tgctggtgag tgggggacag atcattttgt ttcctggcat gctgctcacc 47100 tgggatttcg tagacagtgg gagagggcag tgccttagct ctcctggccc aggggaaatg 47160 gaacctgaag gagccagggg actgcagggg atggagcagc tgcactgagg tggtgaccgt 47220 gccagtctgc aggacatctg cttcttactc cctgtcctgt ccttgctgtg tcccccgagc 47280 ctggagctcc acaggcatag agtgggggtc acagggttca ttgatgagtg aataaggctg 47340 cacagtctcc atcgtatgct cctaacagaa gtcagtgagc ccttgcttgt aacagcagga 47400 gttttaaatt tactctgaaa ttgttattac attgaacata tttcaaagtt cgtagggcag 47460 cttccaaaaa gtaggattcc aagtcgatgc acaaagggct tttgtattgg acacacgcac 47520 acaatcagtt catatcaatc catcagtttt gatgtgatat tgagtaggca ggaaatctgt 47580 atatacattt attgttcatt gctcgtaagc actgaaagtc cttccctcga acataagatg 47640 agactatcca gtttcctgca gtgttttatt tttaatgatt tgatttttaa catacagcaa 47700 tataatctaa acagaattga attttcgatt caatataagc tgagaaactc cctgaattat 47760 tctgagtctc tgtttccttc ttccaagccc atttagcaac caattcttcc tttttccctt 47820 gcctttgccc ttttgccacc tcctttgcta catgtcaaat gtttactttt ttctctcttc 47880 ctcttcactc ttttttaaaa aaacaaacaa acaaaaaaaa actagatctt atccttgaaa 47940 atgtcaaatg tttatatggg cagagatctc ttccacctag actgtttctg tttcttcctt 48000 gcatctgtac cactttcttt ttaaataaag agaagagatt ttaaaaggaa acaaatgaac 48060 aatgccaata cttcctccat gcttattaat gactttgaag attttttttt ttgagacagg 48120 atcttgctct atcacctggg ctggagtgca gtggcaccat cttggctcat tgcaacccct 48180 gcctcctggg ctcatgtcat cctctcacct cagcttcctg agtagctgga actataggca 48240 tgtgccaccg tgcccagcta agttttgtat tttttgtaga gacgaggttt ggtcatgttg 48300 cctaggctgg tctcgaactc ctgaactcag gcaatccacc ctccttggcc tcccaaaatg 48360 ctgggattac aagcatgagc caccatgcct ggcctgatca ttttttgaaa gcaggtcacc 48420 catagccaca catccaccag agtatgaaaa aacttgatca taccaagagc cttctttact 48480 ctttcccagc cttttggccc ttcttatttc aggtaactac agtggataat ttcttgtgat 48540 tctttgctaa actctttatg catataccat ctaggtacat aaatgcatat gtatttatgt 48600 ggtattgaca tgaaaaggat tatatcatgt acaacaccaa acaaaactgt ctaatatgtt 48660 ttaatatctt agacagcaaa tatgttttca aaattatttt tacacatctt ataatttaga 48720 attagataaa atttagaatt ataagatttt ctctagtacc cctcccgccc acatagtcac 48780 tagactttac aaatattaat ttaaattaat acatggttct aggaatgatt gacatccttt 48840 caacattcaa ttttattatc aaagaagata atatttcaag tcaagtgttc tattatgact 48900 caatcgagat ttgggagttt atttcagata aatttttcct attcctcatc aaagctgttt 48960 ctttgcattt tgggtcttct tgtaagtcca ttttctaatt tattatgtct gctgctactt 49020 ttcttttctt tctttctgag atgggtctca ctcttgtcac ccaggctgga gtgcagtggt 49080 acaatcatgg ctcactgcag ccttgacctt ctaaggccaa gtaagctcgg acttaccggc 49140 ttctgagtag ctcggacgac agttttgtgc cactacaccc agcttatttt attttatttt 49200 attttatttt tagaaacagg atctcgctat gtcgcctagg ctggtctcaa actcctgggc 49260 tcaagcagtc ttcacacctc agcctcccag agtgctggga ttacaggtgt gagccaccat 49320 gcctggcctc tgctatgtgg tttaacattc atcagggcta ggtgcagtgg ctcacgcctg 49380 taatcccagc actttgggag gccgaggcgg atggatcatc tgaggtaagg agtttgagac 49440 tagcctggcc aacatggtga aaccctgtct ctactaaaaa tataaaaata cgataaaata 49500 attagctggg catggtggtg cacacctgta atcccagcta cttgggaggc tgaggcagga 49560 gaatctcttg aacccagagg tggaggttgc agtgagccaa gatcgcacta ttgcactcca 49620 gcctgggaga cggagtgaga ctctgtctcg aaaaaaaaaa aaatcatcaa gacatattca 49680 cttttgagta ttacaaatta aaccttgggg ttttaaaaat atacactcct aatctaaaat 49740 attgactgct gtatcggcct ccttccgaga gtcttgcccc tttgtctcct gtcttgttgc 49800 cagacctttc agaacaatgt tctggaagtg acgtgctgca ggtctcagag ctggctggtg 49860 gtcggggtca gtactggact gtaggactcc tggctctgac caggacattc cccactatgt 49920 gttacaggaa ccggcagaag ctgaaaggtc tcagaggagg aggctgctgg ttccagcaaa 49980 tgaaggtgat cccactgaga gtaagtgttt tgctcctgga gatgcagcag gaatggaggg 50040 aatagggaca gggtcctaac tgctgtcccc agaggtcaga gggctcttcc agagtattcc 50100 atgctggaag ccgtgggtcc tgtgctatag accatctgga ccctaaactg tcttctccca 50160 tctcttctcc ccactctacc tcatcctctc tgcaccctat cattgaccct aatgactctg 50220 tccgtcccct catcctctct cctcctttgt tcagggcctg atgtagcccc cgcctgcccc 50280 tgaggacctc ctgaggggct ggcctgtcct gcacagcacc actaacccca gtgggctaag 50340 gagctcttga cctgtgcctc agcccaattt gcagagctgt tgtgtaaact acatacgaat 50400 gccaaagact taatgcaaaa aagagtggaa aatatttcac tcataatttt tgtatattga 50460 ttgtatatta aattatattt taaatatatt cagtaccata cattaaaatg aatgtcactt 50520 gtttctgatg ttctttaaaa taaggctgtt ggaaaacata gcctcgtgtt cctgaccctg 50580 tctatctctg aggacggcga ggtgcatcat gttgcacaca cgtctcattt aatccctcat 50640 cgtcccgaga tctgggcagc attgctcggt ctttgggttc acttcttgct cagagtctgt 50700 ttgcctccac ctagctctgc cccagcccca ggaagtgagg ccgagctggg tgaaaacaga 50760 ggtcccctgt cccaggccct gtgctttcca cagatgcaga agtggccgcc ctgggacctg 50820 ctcccatgac aagcgcagcc caggcagcct cctccctcct ctaagctccc gctgcagcca 50880 ctgtctctcc ctccctcgga ctctcacgca ctttactttc tgcctctgta acgtccatcc 50940 atactcccct ggtgggttct cagccctgta tgagggctga ttctctgacg actttgactc 51000 cccgcagtgc cttgcgtgtg ggggaggcca ggcagtgtgg gcgcgctctc tgtggatggg 51060 aagcgggtgg gcactggagc ggcaggtttg cccgcacacg gggctctcca ggttccccgc 51120 cttgggttct gggcctgatg tggaatcctc tgccctttct gagtcccaac tcacctggct 51180 gtctctgtgg ctttctccac cagctctgag acagtgcttc gatgactttg cagacttggt 51240 gccctttgac tcctgggagc cgctcatgag gaagttgggc ctcatggaca atgagataaa 51300 ggtggctaaa gctgaggcag cgggccacag ggacaccttg tacacgatgc tgataaagtg 51360 ggtcaacaaa accgggcgag atgcctctgt ccacaccctg ctggatgcct tggagacgct 51420 gggagagaga cttgccaagc agaagattga ggaccacttg ttgagctctg gaaagttcat 51480 gtatctagaa ggtaatgcag actctgccat gtcctaagtg tgattctctt caggaagtca 51540 gaccttccct ggtttacctt ttttctggaa aaagcccaac tggactccag tcagtaggaa 51600 agtgccacaa ttgtcacatg accggtactg gaagaaactc tcccatccaa catcacccag 51660 tggatggaac atcctgtaac ttttcactgc acttggcatt atttttataa gctgaatgtg 51720 ataataagga cactatggaa atgtctggat cattccgttt gtgcgtactt tgagatttgg 51780 tttgggatgt cattgttttc acagcacttt tttatcctaa tgtaaatgct ttatttattt 51840 atttgggcta cattgtaaga tccatctaca cagtcgttgt ccgacttcac ttgatactat 51900 atgatatgaa ccttttttgg gtggggggtg cggggcagtt cactctgtct cccaggctgg 51960 agtgcaatgg tgcaatcttg gctcactata gccttgacct ctcaggctca agcgattctc 52020 ccacctcagc catccaaata gctgggacca caggtgtgca ccaccacgcc cggctaattt 52080 tttgtatttt gtctagatat aggggctctc tatgttgctc agggtggtct cgaattcctg 52140 gactcaagca gtctgcccac ctcagactcc caaagcggtg gaattagagg cgtgagcccc 52200 catgcttggc cttacctttc tacttttata attctgtatg ttattatttt atgaacatga 52260 agaaacttta gtaaatgtac ttgtttacat agttatgtga atagattaga taaacataaa 52320 aggaggagac atacaatggg ggaagaagaa gaagtcccct gtaagatgtc actgtctggg 52380 ttccagccct ccctcagatg tactttggct tcaatgattg gcaacttcta caggggccag 52440 tcttttgaac tggacaacct tacaagtata tgagtattat ttataggtag ttgtttacat 52500 atgagtcggg accaaagaga actggatcca cgtgaagtcc tgtgtgtggc tggtccctac 52560 ctgggcagtc tcatttgcac ccatagcccc catctatgga caggctggga cagaggcaga 52620 tgggttagat cacacataac aatagggtct atgtcatatc ccaagtgaac ttgagccctg 52680 tttgggctca ggagatagaa gacaaaatct gtctcccacg tctgccatgg catcaagggg 52740 gaagagtaga tggtgcttga gaatggtgtg aaatggttgc catctcagga gtagatggcc 52800 cggctcactt ctggttatct gtcaccctga gcccatgagc tgccttttag ggtacagatt 52860 gcctacttga ggaccttggc cgctctgtaa gcatctgact catctcagaa atgtcaattc 52920 ttaaacactg tggcaacagg acctagaatg gctgacgcat taaggttttc ttcttgtgtc 52980 ctgttctatt attgttttaa gacctcagta accatttcag cctctttcca gcaaaccctt 53040 ctccatagta tttcagtcat ggaaggatca tttatgcagg tagtcattcc aggagttttt 53100 ggtcttttct gtctcaaggc attgtgtgtt ttgttccggg actggtttgg gtgggacaaa 53160 gttagaattg cctgaagatc acacattcag actgttgtgt ctgtggagtt ttaggagtgg 53220 ggggtgacct ttctggtctt tgcacttcca tcctctccca cttccatctg gcatcccacg 53280 cgttgtcccc tgcacttctg gaaggcacag ggtgctgctg cctcctggtc tttgcctttg 53340 ctgggccttc tgtgcaggac gctcagcctc agggctcaga aggtgccagt ccggtcccag 53400 gtcccttgtc ccttccacag aggccttcct agaagatgca tctagagtgt cagccttatc 53460 agtgtttaag atttttcttt tatttttaat ttttttgaga cagaatctca ctctctcgcc 53520 caggctggag tgcaacggta cgatcttggc tcagtgcaac ctccgcctcc tgggttcaag 53580 cgattctcgt gcctcagcct ccggagtagc tgggattgca ggcacccgcc accacgcctg 53640 gctaattttt gtatttttag tagagacggg gtttcaccat gttggtcagg ctggtctcga 53700 actcctgacc tcaggtgatc caccttggcc tccgaaagtg ctgggattac aggcgtgagc 53760 caccagccag gccaagctat tcttttaaag taagcttcct gacgacatga aataattggg 53820 ggttttgttg tttagttaca ttaggctttg ctatatcccc aggccaaata gcatgtgaca 53880 caggacagcc atagtatagt gtgtcactcg tggttggtgt cctttcatgc ttctgccctg 53940 tcaaaggtcc ctatttgaaa tgtgttataa tacaaacaag gaagcacatt gtgtacaaaa 54000 tacttatgta tttatgaatc catgaccaaa ttaaatatga aaccttatat aaaaagaggt 54060 gtggtttttg tctcccgccc cccaacctcc cctcctcctg tgaatcagct ctgagtgaca 54120 ggaaaccagg gctgtgctcc tgctgggact ccttccttcc tccctcccct ctgttttcag 54180 gcttggcctc ctgggggtgt ttcctgaatc cgactcccca gagtttaaag agctaggttc 54240 ctggggactg ggattcatac ctccttcccc tctctctcct gcctgctcct ccctctgggg 54300 acagggacac caatgttggc ctggctcacc cacagcctcc caggagagtt ctctgggctg 54360 ccgggttgca tctggttccg acagctctcg gggaatgggc ggtgggtccc tgaagttggg 54420 gggccggccc tgtttctcag ggaatcccgt ggtcactctc ctatggcttc ctacagccct 54480 gggtcgacct tcactttctc tgccccggcc ttccctgcat ccccaccagg gtacccaggt 54540 tgctcagcgc ttcaggcacc taggagacct atttcccgtt ccccttgccc tggaggaccc 54600 gctctccctt tcgtccacag cttccgggag gcccaggtgt gcccccacgc tgtccatctt 54660 ccctagaagt ggaggtgctc cgggttcccc cttcgtcccc ccagccctgc ccatgggctt 54720 ctgggcctca cttggagccc tgggctgcgc tgagctgcag ggaggccgag cagcctgtag 54780 agggcagcat acgcgtggct ttccagccag ccgccctgga ggccgtggag gggaggcagc 54840 cacagtcctg gaggggcctg ggcctggaca acatggccgc ccccagggtt agagccgctt 54900 gtcctccagc cgcctggtct ctcttgatga ggatttaacc tctggtcatt aggtcctgcc 54960 tgctaccttt gtttcaggtt agctcaatcc caggcctaac cagcgttttc ctggagccca 55020 ccccagggcc aggccctctc agctagaaca tctctctcag gtaaggcgac tcctgagctc 55080 tgagcccaca gccccactgc ctcctggctc tgcccctcct ccgtgggact ccatctttta 55140 cacctaaaaa gagtgtgggt ggtgaaatct gagtcggggt tagaaaacgg aaaggggcaa 55200 ttgtggccca gctgctgccc catgggggct gggagctagt ttcaatcccc cacattcctc 55260 cagccccgcc ctcctcctct ctagaccaac tctgcttttc ctcctgctcc attctccctc 55320 ttctccttcc ccttatccca ccccagcagt aataaggctg tgtcctgtgg cctttcacta 55380 caggtcagtg cccctttccc tgacttttgg cccctattgc agccccgcaa aaacacccac 55440 cataagcact ctctgagggt aaggaaggga gcctgcagtc tccagatggg caaaagcaag 55500 agtctggtgc catttaagcc ccgagaccaa acccctcttt gccgccagcc cgggcccctc 55560 aatcaccagc cctctagagg ccaggcccct gtgttgccct cggagccagc tggcagggtc 55620 agggcctccg cagtcagaga agtgccgagt cctttcctga aaggcattgg agtcgattct 55680 gcaacctaaa tcttcacctc ctcatcatgg gggcctctgt ttatagaaat gtgagctagg 55740 caggggcttt ttctgatttt cattctttgg agggatagag gacagagtgt ttgttgattt 55800 ttcgtttcgg tttcagtttg gttgtcattg gtttttgttt tttgctaatt ttgccccacc 55860 ctataaaaag cagtgccacc cagaggcagg ggagggccct gaggagcacg gggtcgccgt 55920 gcactcattc ctacttcctt ctccacctgt cccagctgct tcctttggtt accatctcca 55980 aatctgaggg taaaggaggg ggtgagggag aagtttcttg ttgcaccaag aggcactgct 56040 tccaggcctg gagct 56055 <210> 27 <211> 200498 <212> DNA <213> homo sapiens <400> 27 tgacctcaag tgatccaccc accttggctt cccaaagtga tgggtgggat tacaggcatg 60 agccactgca cctagccaag ctcaatgaat tttaaaatat aaatgtgtgt gtacgtgtgt 120 gtgtgtgtgt gtgtgtgtgt gtatatatat atatatatat atatatgttt aaaaccacat 180 aactaccacc aaatcaagtt atagaacatt tacatctccc taggacattt cttcctatct 240 tgactttgat caacatatgt tgttgttatt attattatta ttattattat tattattatt 300 attattcaga gacagggtct acctctgttg cccaggctgg agtgcagtgt tgcaatcgta 360 cacaattcac cgcagtctgg aactctgggg ctcaagcaat tctcctatct cagtttcctg 420 agtagctagg accacaggtg tgtgccaata tgcccagcta atctttaaaa ttgttttgtt 480 gaggcaggca tggtggctca cgcctgtaac cccagcactt tgggaggccg aggcaggtgg 540 atcacaaggt caggagtttg agaccagcct ggccaacatg gtgaaacgcc gtctctacta 600 aagatacaaa aaaattagcc aggcaccgtg gcacgcacct gtaatcccag ctacttggga 660 aactggggca ggagaatcac ttgaacccgg aaggcagagg ttgcagtgag ctgagatcat 720 gcctccgcac tccaacctgg gccaaaggga gagagtctgt ctcaaaaaat aaaaaaaaaa 780 aagaaatttg ttttgtagaa atgaggtctc actatgttgc ccaggctggt ctcaaacttc 840 tggcctgatg agcaatccgc ctgcctgggc ctcccagatt gctggtatta cagacatgag 900 ccacagtgcc tggctcttga ataatgtata ttagttttgc ctattgttga acatcgtgta 960 aatgagatca tggcaaatat gctcttttgt gtctgccttg ttttgctcct tgttgtgttt 1020 tgtgggattc atacatattg ttgctattat gaacattttt tgtagatgtg ttttggtgga 1080 tgtaagctca cctttctttt ggaggcgagt ggaatttctg tgtcactatg taattgtatg 1140 tttcacttta gcacgaatta ttagttttct ttcttttttg gagatggagt ctcactctgt 1200 cacctaggct ggagtgaagt ggtgcgatct tggctcagag caacctgtgc ctcctgggtt 1260 caagtgagtg ttgtgcctca gctccccaag tagctgagac tataggcatg tgccacaacg 1320 cccagctaat tttattttat tttattttac ttttgagaca gagtctcact ctgtcgccca 1380 ggctggagcg cggtggcgcg atcttagctc actgcaacct gcgcctccca ggttcaagca 1440 gttctcctgc cttagcctcc cgagtagctc ggattacagg catgtgccac catgcctggc 1500 taattttttt gtattgttaa tagagatggg gtttcctcat gtcagccagg ctggtcttga 1560 actcctgagc tcaggcaatc cacccacctt ggcccacctt tttgtatttt ttgtagagat 1620 ggggtttcac catgttgctc aggctggtct caatctcctg agctcaagag atccacctgc 1680 ctcggccacc caaagtgctg ggattacagg catgagccac tgcacccagc caaattgtta 1740 gttttccaaa gtagttaagc caatttatat acctcccaac agagcgtgcc ttttccagtt 1800 aatccacgtc tttgtctgca ctcgtaattt tcagtctttg tttccagtca ctctggtggg 1860 tgtatgatgg tatttcactg gggttttatt tgcatttccc tgatgactaa tgaagttgag 1920 catgttttca tgtgcttgct caataaatat ttgttgaaag gatgaataaa gagtgaatga 1980 ataaaacatg gaaagaaatc caactctgtc ttgtgccctg cctaaaaccc accagtggtt 2040 cccactgccc ctcctttggc cgacgggtac ctgcctgccc tggctccttc tgaccccacc 2100 tgctccggat ggatttcttt tgcttcttct ctgggttcct gccatccagg ctgtcttcag 2160 tttcctccaa ggaccctccc tgcttcataa ctttgctata aactgttttc ttctgcccag 2220 aacacaaccc aggcccaagg aacccagacg cgttccttgt atctcagttt gaaagcctct 2280 tcctccagga agccttctct gacttccacc ccccagcaag ggtggtataa attgctaact 2340 taggcccact tttgcccact ttttttgttt gtgtttttga gatggagtca cactttgtcg 2400 tccaggctgg agtgcagtgg ggccatctca gctcactgca acctccatct cctgggttca 2460 agtgattctc ctgccttagc ttcctgaata gctgggatta caggcaccca ccaccatgtc 2520 cagctaattt ttgtattttt acatttattt atttatttat ttgagataga gtattgcttt 2580 gtcgcccagg ctggagtgca gtggcatgat cttggcttac tgcaacctcc gcctcccagg 2640 ttcaagtgat tctcctgcct cagcctcccg agtagctgag cctgcaggtg cctgccacca 2700 cacccagcta atttttgtat ttttagtaga gatggggttt taccatcggt cagactggtc 2760 tcgaactcct gaccttaagt gatctgcctg ccttggcctc ccaaagtgct gggattacag 2820 gcgtgagcca ccatgcccgg ccaccacttt ttttttctag ctgtgaccat agttgtacat 2880 atctcccctt ccctggcttt tttttttgtt ttttttttcc tgagacagga tctcgctgtg 2940 ttacccaggc tgcagtgcag cggtgcaatc atagctcact gtagccttga actcctgggc 3000 caaatgagcc tcccacctcg gcctcccaaa gcactgagat tacatgcgtg agtcactact 3060 tctggcctgt aaataccctt tcaaaaatat aatatttgat taacatctgc catcttacca 3120 taagaaacac ttaaaaaaat cccaatccaa aaaaattcca atcctttaag ctatataaga 3180 gtagcaattt tatcttgttc ctagcaagac atctggcata tagtaaatgc tcaataaata 3240 tttgttgaca gtataaaggt caagcaacag cataactggc attattacat gaaagtaatt 3300 atcccttaga aactcattca cccttggggg acccgggcca ataaaaaaat cacagaaaac 3360 aatcctatct accttcctcc ttcctccttc cctcgctagg tcctttgatt ggggggaggt 3420 ctcaaatgca cacactgttt ctgttttatt tggtgcagct gttgtgtgca tgtgttatgg 3480 aaacccacat caggcaggag attaaggagg agaggagaaa agaaaggcat cgctggtatc 3540 acagtgaaat ttacactctg cggcctcgcc ctagctcctc tgtctctacc tgtctgccta 3600 tgaaacagtt caaaactaat atggcgcaat ggatggtatt atagacttcc cacctccctg 3660 gccagacttc ttgggttcaa agtttggctt aatcacttac catctaaata atccctgaca 3720 atgtactctg tctttctggg ccttagtggc ctcatctgca aaatggggat aatactactt 3780 cttacctcat ggggttgtga ggattgcaca agttaatttg tgtaaattgc taagaacaca 3840 gccttaggaa gccttgtcac tgtgaatgca tattaatttt ttttattatt attttttgag 3900 acagagtctt gctctgttgc ccaggctgga gtgcagtggt gtgatctaag ctcatttcaa 3960 cctccgcctc ccaggttcaa gtgattctcc tgtttcagct tctcaagtag ctgggactac 4020 aggtgcccgc caccatgccc ggctaatttt tgtgttttta gtagagacag ggttttgcta 4080 tgttggctag gctggtcttg aactcctgac cttatgtgat cggcccgcct cggcttccca 4140 aagtgcttga ttacaagcac gagccaccat gcctggccta cgattatcat gtctccaggc 4200 ttcagtttcc ttacctctga ggtgaggatc aataacctgg ttatttctaa gtgatgctta 4260 aagaggttga gaagaagcaa aggcgctctg cacacaggtg aggtcaacag ctgttagtga 4320 tggagactgg cgccgtctgg gtcatcagtg ctccggaatc aggctgctca cgggtttgaa 4380 tctcacttcc actttcactc cttattaact gtgtgacctc gggcaagtca cttcgccttt 4440 ctgaacctca gtttccccat ctgtaaaagg taggtgaata acagtattca cctccttctg 4500 tgtgactcag ctttggagtc agcggaccgg gttcaaatcc cagccctgca agtgattagc 4560 caggtgaccc tgggcagagg gaatcactca acctctctgc acctgggttt cttccttcat 4620 gaacgtggag actttacagg atgaaatgag ggcacagtta aggcgcccgg tacactccag 4680 gcaggtaggg ggctccgttc acgttatttt cccctggtga cggatactgt ccttaaacag 4740 catttgaaaa gtggtcgcag ggtgtgtggc cccaaagatc ccaggcgctt ccggaaggcg 4800 agccaacgct ccccaggccc gtccgcgagc gggtgggcct aagccttgga ggatctgggg 4860 tgggggtggc gcggggtcca ggcccggggc gccgagaggt ggctggtccg gctgcccacg 4920 ccgagacgcg cgaggtgagc gggcgccggg gcggggcggg gtggggcggg gccgccgcat 4980 ccccgtgacg cgcgggccaa ccaggcggcg ttgcggcccc ggccccggct ccctgcgccg 5040 ccgccgccgc cgccgccagc gctagcgcca gcagccgggc ccgatcaccc gccgcccggt 5100 gcccgccgcc gcccgcgcca gcaaccgggc ccgatcaccc gccgcccggt gcccgccgcc 5160 gcccgcgcca ccggcatggc gctccggggc ttctgcagcg ccgatggctc cgacccgctc 5220 tgggtacgtg ccgggggccg cgtgaggccg gcgggacgga gggaggccgg cggggaggga 5280 aagcaccggg cccgcagccg cccggggcac cccgctcccc gctctgctgc cggcctcggg 5340 ggcccgggac cctcacgtcg cccgcggccc agcccctttc gggggtgcaa ggcatggggg 5400 aaacttgggt gactcagttc ctgcggagca gagcgtgggg ggccgcgtgc ccagccctgg 5460 ggttttggag ggtcgggtcg ggtcagagcc gccgtgagga ggccttcctg ttttggggtt 5520 cccgtctgta aaaacaacct tccagggaag gggacgctag agatgggggg cgggaagagg 5580 ggtgtctctc tgcttctgtt ttcccatctt ttttgtggtt agggtccccc cttttcacga 5640 aaaatactcc gtgaccaacg gggtgagctg gggaggggct tagattgtag aaagggactt 5700 tcattgtctc cccaaagttg tcgtacaagc cacattactc ttctgtggtt acctagcttt 5760 gttttttttg ttctttctac ttagatactg cgggggaagt ttgggggaac cagggaagaa 5820 gggggatgtc cacccttgat gtgccctacc tgaccctcgg ctcggggcag acttggggtg 5880 cagctgagga cgcccaggac cctggtagct gtggtcctgc cctcccttcc ctgcaacacg 5940 tggagctcct ctctggggat gccccttaga tttaaccccg gcaagttttc ttctgtaacg 6000 tggcctgcgg agcctgactg ggtgtctgga gtccacttgc tgtggtttaa gccccagtct 6060 tttgggcttc agcttctccg taatgcgatt tgcctctttg ttccaggaag gcaggcactt 6120 ctgtctcgtg ctgtcttgat tgttggtgaa cgcagtaggc aaatctggac acgactgttt 6180 ctctctcctc ttttgtttag gaatcaggag aaacagcctt ggttcttagg agctggtgat 6240 cagcttccaa aaatactttc ttgtcctgtt ttgccggcct ttcctcgagg gttgcatttg 6300 gagtgttgaa aagtcatcct ccagggcccc attggagggt ttggttttgt ttgtttgttt 6360 tttttagtag ggtatcattg tgtttaataa cctaccacac tttgatatat ctcccatttt 6420 aagccagtgg ggttggagag taaccccagg ggtggaaata gaacacagac tttgccttga 6480 gggtctgggg gtgattggag cctctttgca gatggacttt ctttagcagg ggaaaacctg 6540 tggcttcctt gttgccaggt gtagtaacag caagattatt ttttgcaaag attcacatgg 6600 tgatctgggt ttgtgttgct gtgaattcca gaatattctc ttgtttattt tcttctgaat 6660 tgaggagggg gcaaaacagg gtgaacatcc atgaggtttt gtatcaggac gtattttatt 6720 gatggcaatt ggtagttgat ggctaatgag tatgtttggg gtgcgctttg tttatcttaa 6780 gaaactcatt cacgaagtcc agttgtaata ttttttaaaa tttttatttt cttttttctt 6840 tttatttttt ccttcgttaa ggactttctg ccacagaaat tgccaggtgg ttgggttttg 6900 cttgggggta attgtagctg atctctgcct ctggtaggta ccccatcccc gtgtttgacc 6960 ttgcgtattt ctgctgtctg gattccaaga cttgttggag gtgccttgga accagaattt 7020 gagaggaggc aactggggcc tgagtgggaa aattgaaata taattaactg aaagctagaa 7080 agtaggtagt tgttgctttt ttcttttctt ttttttttct ttttcttttt tgagacagag 7140 tcttgctctg tcacccaggc tggagtgcag tggcacgatc tcagcttact gcaatctctg 7200 cctccccggc tcaagtggtc ctcctaactc agcctcccaa gtacctggga ctataggcgt 7260 gtgccaccac gcccagctaa tttttgtatt ttttatagag acagattcgc actatattgc 7320 ccaggctggt ctcctactcc tgggctcaag cgatcctcct gccttggcct ccaaaagtgt 7380 tgagattaca ggcatgggcc tctgtgcccg gctgtttttg tgtttttcaa ggtagcgtgt 7440 ccgaggccag gagcgactgg cctcccaggc agtcagataa ctgtgtgacc ttgagcaagc 7500 cactttccct ctgtgtgcct cactttcctc atctctaaaa ttggacagga gccaaaaatg 7560 tggcagcctt cttgggttgt tgcgaagggt caatgagtta atcttgtaag tggctcagct 7620 tgtgccctgc acggagataa acaatggtta gtattaaata ttattttttc caaagatgaa 7680 gttgtgtgtt ttaagctcct tgttcttcct ttggattccc cttttcttca gctggtggag 7740 atgggattgg gctgtgaaaa ggcagtgagg cacccgtgcc tggctcctgt tgtgaccaag 7800 gtcatgtgct tagaagtcaa ggtcagtggg cctcgggtga ctctgtcaga gctttgtttc 7860 tgggctactg tctgcctctg agccgcagga aatgtccaga aaacccagaa gatggaaatg 7920 gcccatgata agtgttctgt tgacctttac tcagacagat gctctgggaa gagaaaagga 7980 gaactttgct atcaaaacgg aaaatagggc ctgaggacag gtcacagcag cccttggctt 8040 tcttttctca tgggggtggg actggtagga ggcgctgctt tgtggttgat attggcatga 8100 tggttggaaa aatgggcctg ggactttttg tgagttcatt aaaaaaaaaa aaaaaaaaaa 8160 aaaaaaaagc aggccgggtg cagtggctca cgcctgtaat cccagcactt tgggaggctg 8220 aggcaggcgg attgcttgag gtcaggagtt cgagaccagc ctaggcaaca tggattgacc 8280 cccgtctcta ctaataatac caaaaaaaaa aaaaaagcct ggcatggtgg tgtggcacct 8340 gtggtcccgg ctactaggga ggctgaggca ctagaatcac ttgaaggctg tgggggtgga 8400 ggttgcaatg agctgagatc acggtcactg cactccagtc tgggccacag actgagaccc 8460 tgtctcaaaa aaaagagggc cgggtgtagt agatcatgcc tgtaatccca gcactttggg 8520 aggccaaggc aggcggatca cctgaggtca ggggttcaag accagcctga ccaacatggc 8580 aaaaccccat ccctactaaa aatacaaaaa ttagctgggc ctggtgattc acgcctgtaa 8640 ttccagctac ttgggaggct gaggcaggag aattgcttga acctgggaag aggttgcagt 8700 gagctgagat cacatcactg cactccaacc tgggcgacag agagactgtc tcaaaagaaa 8760 aaaaaaattg tgcttcaggc cctgtgtaga aaaattggaa attatggaaa agcagaggaa 8820 acaacttggt attaagcagt atagtgtggt ggctcagagc aaattcgcct ctgctgctga 8880 ggcaggttac gtcatctctc cgtgcctcag tttccctatg tgggataacg tagtacctag 8940 tgaatagcgg tgacttgagg aataagtgag ttaatcctta gcaaggactt aaaatgttgc 9000 tgcttggcac acagcgctca gtaaagatca gtggtcgttg ccacctggaa ttctccagtt 9060 aatttttgct gttgcaccaa ctgccactgg agaagaccag aaggaagctg caggtgtgtg 9120 tcaccgtcga tggagtgagc tggtcccagg gttgatgtgc acctctgaga tgctctgtgg 9180 catccaccaa ctcagtaacc ccctgaatat ctgacttagc cgccaaggaa gaatatctta 9240 gaagctatta ggaattcctc ttggggctag gtctgggcct tggagtcagt ctgatccctg 9300 gtttaattct tccccttggc tcaacagcag tgtacgacga gccaattttt cccctcctcc 9360 aagtgtggct ttggttttca aatccatccc ttagccttct cctacttcct ctgttttccc 9420 ctccccaccc tttttttttt tttttttttg agatggtgtc ttgctgtgtc gcccaggcta 9480 gggtgcagtg gtgtgatctc ggttcactac aacctctgcc tgctgcgttc acatgattcc 9540 cctgcctcag gctcccgagt agctgggatt acaggcgcac agccaccatg cctggctaag 9600 ttttgtattt ttacaaaact ttacaaaacc cccatagaga cggggtttca tcatgttggc 9660 caggctggtc ttgaactcct gacctcaagt ggtcaacctg cctcagcctc ccaaagtgtt 9720 ggggattgca agcgtgagcc accgcgctca gcctgttttc cccctttttg gctgcccctc 9780 cttccagacc cttcctctct cccttcctta tggagtgtta gagtggaaag ggatgtcaga 9840 tcttgggggg ccctcctctc cacccacccc atttcgtgga tgtggacact gaggtccagg 9900 atggtgacat gacagggtgc aaggtggcaa ggtgaatggc tttgggagga gatgagggtg 9960 acccgggaga ggcctgggca ggagtggact caggggttcc tggtccaaat gggttcgtga 10020 ttcaggccaa tcaggagcgg attcagggtt ccttggccaa atggagccac tgcagccaca 10080 ggggccctgc agaaggcagc tgcagccggt ccctttggcc aagactctcc tgaagggtcg 10140 tgttctcttt ctccgaggac aagttccatt tgtgatagcc tggagggggt gcctcgcctt 10200 tgggacctgg tggtagatgg gggggaagaa aaccttttct gtttgtggac acaactttta 10260 ggaactgatc tctctatgtg ggtgtctccc actgaccatg ttcctaaaga acgtgagctt 10320 cctcttccca tgtcagtctc cagctttgac ttctcttttt ctcctcccat tcctatcaca 10380 tctgtcagca aatcgtgttg cccgttgcct caaacgggct gcttttcatg gcttccccga 10440 cttccactct ggctcgagtc atcgttggcc agtttctgga tttgaacagt cacctcagtc 10500 caggcgccgt ggctcatgcc tgtaatcctg gcacttcggg aggccaaggc agacggatca 10560 tttgaggcca ggagtttgag accagtctgg gcagaatggt gaaaacctgt ctcaactaaa 10620 aatacaaaaa ttagccgagc ctggtggtgg gcgcctgtaa tcccagctac ttgggaggct 10680 gaggcaggag aatcgcttga gcccagtggg gttggaggtt gcagtgagcc gagagttcgc 10740 cactgcgctc cagcctgggt gacagtgaga ctctgtctca aaaaaaaaga aaacagccac 10800 ctgttcgctg ctgtgcctac tctgcccttg acccctacag tctagtcttg gcccagctgt 10860 ccctcttcta ctaaaaccct gcagtagttc cttgagggta caagccaaag ggcttacagt 10920 ggcctcgaag gctgggcagc atctgtcccc ttggcctccc tgacctcttc tctggctgct 10980 ttctgtctca ctctcctcca gccacacttg tggccaggcc tgtccctgcc tcagggcctt 11040 tgcacttgct gtttctccta cctactatgt ccctcacctt caaactttgt tcaggtgtca 11100 cctcaggcat cccgttcttt ccctccacta gcaaatctct gtcccccatc tacaccccca 11160 gtagcactta ctgccttcta atacacgtaa tattttgctt aagtattgtg cctactctgt 11220 aaactcctac caaaagatcg gctccatagg ggcagggatt ttggcctgtg tttgtttacg 11280 gctgtaatcc cagcacctag aactgtgcct ggggcttagt aaataacagt tgaccttgga 11340 acaattcagg ggttaggagt gctgatgccc catgtagttg aaaatttagg atgcagcgcg 11400 gtggcttaca cctgtaatct cagcactttg ggaggccgag gcaggtggat tacctgaggt 11460 caggagttcc agactagtct ggccaacatg gtgaaagccc atctctacaa aaattagcca 11520 ggtgtggtgg ctcatgcctg taatctcagc actttgggag gccaaggcag gcagatcact 11580 tgaggtcagg agtttgagac cagcctggcc aacatggtaa aaccctgtct ctacaaaaat 11640 tagctgggtg tggtggcggg tgcctgtaat cccagctact tgagaagctg aggcatgagc 11700 attgcttgaa cctggtaggc ggacactgca gtgagccgag atcgcgccat tgcactccag 11760 cttgggtgac agagtaagac tctgtctaaa aaaaaaaaaa cacaataaag gaaagaaaat 11820 tcaggtctaa ctttcaactc cctaaaagtt taactactaa cagcttactg ttgactggaa 11880 gccttaccga gaacataagc agttgataac actaattctg ttgttgttgg ttgttttttg 11940 atagagatgg ggagcttgct gtgttgccga ggctggtctc aaactcctgg cctcaagcta 12000 ttcacctgcc tcggcctcct aaagtgctgg gattataggc gtgagccact gcacttggcc 12060 taactcatac cttgtatata tattatatac tgtattttta cagtgaagca aggtagagaa 12120 aagaaaatgt taagattaat tcataagaga gatttttact atttattaag tggaagtgga 12180 tcatcataaa ggtcttcatc ttcattgtct tcacgttgag gaggctaagg aggaggagga 12240 aggggagggg ttggtcttgc tatctcaggg atggcagagg cagaagcata atctgagtat 12300 aagtggaccc gtgcagttta aatgtgtgtt gttcaagggt cagctgtttg ttgaataaat 12360 gaatgacatg aagtattaca gtggcttttg ggcggtgtcg aaacttcttt gtaaggattt 12420 taaggatgaa ataatcactt aactgtctgg aatgaacact cagataaact gagtcctcca 12480 gctttctcat cagatggctt gtttttttat tttatttttt tgagacaggg tcttgctctg 12540 tcacccaggc tggagtgcag tggcgcgacc tcagctcact gcagcctcaa cctcctgagc 12600 tcaagcaatt ctcccacttc agctccccag gtagctggga ctacaggcac acaccaccat 12660 gcccagctaa tttttttttt tttttttttt gtagagatag ggttttgcca tgttgctcag 12720 gttggtggtg aactcctgaa ctcaggcgat ctgcctgcct tggcctccca aagtgctggg 12780 attataggtg tgagccaccg tgcttggcag aacagcttct atttcatctt ggaaaggtca 12840 gaacagggtt ttgtccaccc ctcttttccc aggactcagt gtctcacaca cagtgggggc 12900 tcaatcaaca ttagaatttg agtgtttgag gtatgagttc caagctaggg gttagatata 12960 gctcaccact gtgctggttt ggcttgattt taattatagg aatgactgtg atttccaatt 13020 ttatttattt atttatttga gacggagtct tgctctgttg ccaggctgga gtgcagtggc 13080 acgatcttgg ctcactgcaa cctctgcctc ctgggttcaa gcaattctgc ctcagcctcc 13140 ccagtagctg ggactacagg ggcacgccac cacatccagc taatttttgt gtttttgata 13200 gaaacggggt ttccagtatg ttggccagca tggcctcgat ctcttgacct cgtgatccgc 13260 ccgcctcggc ctcctaaagt gctgggatta caggcatgag ccactgtggc ccgccctaca 13320 atgtttattc attggcagat ttcacagaaa catctggatt tctggcttcc cttgaaaaat 13380 cagaagttct gctagcccca ggcccacatt tatacatggt agcggtccgc tgaggctgtc 13440 cgtttctgag ttgctccagt ttgccgcagt ccccacccct ccctgttgtt gctttaattt 13500 taaggccaaa tgtttgttgc ctttgtttta ttttatatta tttttttgag acgaagtctc 13560 gctctgtcac ccaggctgga gtgcagtagt ggaatctcgg ctcactgcaa cctctgcctc 13620 ccgggttcca gtgattctgc tgcctcagct tcccgagtag ctgggattac aggcccgcac 13680 caccacactc ggcttatttt tgtattttta gtagagatgg ggtttctcca tattggccag 13740 gctggtcttg aattcctgaa ctcaagtgga tcacttgagt tcctcagcct cccaaagtgc 13800 tgggattaca ggcatgagcc accgtgcctg gcctgttgcc tttttaaaat tgtgcttcct 13860 cacacctggt ctgcttcttg catggatgga acccactttg gcacctgttg gtatctgagt 13920 tggcatctcc tgctttgcag gccaaccttg aagttagcat ctgattggta tgttggcttc 13980 agattttcat ggcgaagtaa ggcctagctt tgatgatcag ctcttagtgt ggtcagtaca 14040 actctagctc gtgaaaactt gcccaaacat tttgccaaaa ttaattaatg gccagacatc 14100 ctgaggcaag cttccccccg cttagcaaga aaactgggat agggcagcat ccctgtgggt 14160 ggagtggtgc tggggacctg cacttacctc ttagaggctg aatggttgaa cggggccttt 14220 gaggaagctg tattttgcgg gtggggacat ggagcacagt tgctcagtgt cggccccgtt 14280 gacatgtagg ccacatcatt ctttgtggcc tggttgctgt tctgtgcagc gtagtcttag 14340 ccccaaacct ggcctctacc ccctagtaga tgctggtagc acctcctctt gttgtgacaa 14400 ccgaaaatgc ctctagatgt ttccatatgt tccctggggt gtgaaatcac acagccactg 14460 gtgtggagga atatggggga gaaacatgga gcaagacctt cctcctcatc ctgcatttcc 14520 ctaggaggtt gtgggctgtc gaaattctag tgtaattggc ttactggggt tgccttggag 14580 aagcttaatg agacgttaag gaggttaaac tccaattagc tagagaagaa acttgcggca 14640 gtttcttttt tactgagggc tgtgtctttt tacctttttc cattttccca gttggagttg 14700 tgacagttca ttctcccctg ggaaaacaaa aatggctttc tttttctttt tctttctttt 14760 ttcttttgag acagggtctc cctctgtcac ccaggctgga gtgcagtggc acaatcatag 14820 ctcactgcag cctcgacctc ctgggctgaa gctatcttcc caccttagcc tcccaggtag 14880 ctgggaccag aggtgcacac caccataccc ggctaatttt tgtatttttt gtagagtcag 14940 ggtctcacca tgttgcccag gcttgtctca aactcctggg ctcaagcgat cctcctgcct 15000 cggcctccca aagtgctggg attacaggcg tgagccacca tgcccagccg aaaatggctt 15060 tcttgagaga tcagctttga agctctactc cttcatttta aagtgcccca ggagaagtgg 15120 acgattacaa agttgagatt ccacttaagt gtccccttag tttaactgtg ggattcatct 15180 cctggggagg ttgccaggtt ctggaaagtg ggtgttaatg accagggagg gtgcccctag 15240 gctagcatcc tgtaaccctc aggaattgag atttttatgg aggttttctc ttcctctctg 15300 tgagttttct ctctgagaaa cctgtctagg gagggaggct ctaggctagc atcctgtaac 15360 cctcaagtag taattgagat ttttatggag cttttatctt cctctctgtg agttttctct 15420 ctgaggaacc tcagtgtacc ttttactggc ctcctaggta atacttgttt ggagaatatg 15480 tgtgatgtct aagtcttccc agtacaagaa atttgtgtgg tgtttgactg attgatggat 15540 ggagtcttgt tctgtcgccc tagctgattg taccactgca ctgcagtctc gacctcccag 15600 gccaagtgac cctcccaact caccctccca agtagctggg actacaggca tgcaccagca 15660 cacccggcta atttttgtat ttttttttgt agagatgggg tttcactatg ttgcccagtt 15720 tggtcttgaa ctcttgagct caagcagtct cccagagtgc tgggattaca ggtgtgagcc 15780 accacgccca gcctcgtgtg gtctttgata cccctgggtt cattgtattg ttcttcccac 15840 actgcttttc attcattcat ttattcagtc attattaatt gagcagctac tatgtgctgc 15900 tgctgctcta ggcactgagg atacaacagt gaacaggaca gaccaggccc atgttctcat 15960 ggggtttaca ctgagggtga cggaaatgat ttcagatgct ggcaagtgct gcaaagactt 16020 gaaccgggaa aaactgggtg aggtgcaaac tactacggag ggatgtccac agaaggcctt 16080 tcggaggcgg tgaggtttga ccccagagct cagtggcaaa gctggccatg caaggatgtg 16140 ggggaaggga gtcccagagt gggaagagaa tgtgcatagg ccttgaggaa gatcatggtg 16200 tggttaaagt attgaggagt ttaactcaaa ggaactgcag agcccatctc ataaaaatct 16260 agcctggagc attcggcaaa atgcataaag cactaacaca atggcttgtg gtcctggaat 16320 ttccagggaa ggcgcttacc agctcagcaa ggaagtagaa caatgcatgg tccctggcag 16380 aagcaagaac cttctgatct gtttatgttt gaatgaaacg caggtttttt tttttttttt 16440 ttttttttaa aatagatggg ggtcttgcta tgctgctcag gctggtctcg aactcctggg 16500 ctcaagcaat ccacccacct tggcccttcc atgtgctggg attacaggca tgaggcacta 16560 cgccctgctg aatctcaggt cttaaaaatt cagtttattt tgttttatga gtctcttctc 16620 tttctcagaa ccttaactga aacgtttgtg atcaagacca acttgggttt ccccactccc 16680 cagttgcctt tgattctccg ccaaaggctt gttcgtaaga tgatgaggta cttttttcct 16740 gtggttaaga ggactttcta taggttgcta gaaaactctt gttttaaaac aagatgttgt 16800 tgaattgatc tggctgattg caggaggaag atcttgtact gcaactttgt tgatgatgct 16860 aatactttaa ggtgaatatt ctagaagaat ataaagggaa aaataaaagt tttagtatgt 16920 tcccaccctg ccctttgttc ccagaagtag ccgttattga tgatggttgt tgatgatagt 16980 ttcttgggtg tttttcgaga aaagtttcaa gtatatgcaa atgtatgtgc aagaacgtgt 17040 tcgtttgtgt gtatatgttt acatattcat tttttccctc cctagttggg tattttaaat 17100 actgttttgt ctcttgttct cttcacttaa ccagtgttga ttttcttgcc attttaagcc 17160 catgcaaatt gaaagtaaaa gccaatcaaa tcaacttttt tttttttttt tttttaaaca 17220 agccacgcat ttgcctgtta aatggctgag ccatgtattc acccattccc ctcttggtgt 17280 ctatcaaggt cattcccagt tcctggtttc ttgctgtgat aagcagtgct gcactgaagg 17340 cacatgtatg caaatatatg taaatgattc agcagaataa attttcccac aggaaattgc 17400 taggttgaca gtatgtgcat tttgaaattt gatagttaat tgtcaggtta ctgcagcagt 17460 ttatactccc actaatgggc ccaccagcac ttattaagca cctgttgttt tcctgccata 17520 tcagaaaaat tgagcaagct gggaagtgat caggcccatg ttgcttggct gtgtgtgaga 17580 gggctttgcc cagttaagtt aaaccttact ttccagaggt caggagatca aagcagaagt 17640 gtgctttggt tttgttcagt tttttaaaag atgtgtttaa attttaaaca tctttggact 17700 tattttaaaa attgctttta aatcaataat ttaacaatgt gtaaaaacat tactgatagt 17760 ctcaccatgc taatgtcact ctgattttta cacctaaact aatttaattg cagagttttc 17820 tgatcacaag tgacatgtgt tccatatgac agaacaaaca atacaaagat atttaaataa 17880 agcctgaaca tggtactgat attagtttgt tcatgctgct atgaaaaaat acctgagact 17940 gcgtagttta taaaggaaag aggtttaatt gactcacagt tctgcatggc tggggaggcc 18000 tcaggaaact taaaatgatg gtggaaagga aagcaaacat gtccttcttc acatggtggc 18060 aggagacaga agtgcagagt aaagaggaga aaagccggta taaaaccatc agatcttctg 18120 aggactcact atcaggagaa cagcatgggg gaaccgctcc catgatctaa tcacctccag 18180 tgaggtccct ccaccaacac gtggggatta caattaagat tacaattcaa gatgagattt 18240 gtgcggggac acagagccgt gccatatcat tctgcccctg gcccctccca aatctcatct 18300 ttctcatatt tcaaaacaca attatgcctt cccaacagtt ccccaaagtc ttaactcatt 18360 tcagcattaa ctcaaaagtc tatgtccaaa atctcatctg agacaaaatc tagtctcttt 18420 cacctatcag cctgtaaaat caaaagaagt tagttagttc ctagatacaa tgggggtaca 18480 ggcattggat aaatacaccc gtttgaaatg ggagaaattg gccaaaacaa aggggctgca 18540 ggccccatgc aagtctgaaa tccaataggc cagtcataaa actttcaagt tccatagtta 18600 tctcctttga ctccgtgtct cacatccagg tcacactgtt gcaagaggtg ggcttccacg 18660 gccttgggca gctctgcccc tgtggctttg cagggtatag ccccgctcct ggctgctttc 18720 acaggttggc gttgagtgtc tccgtctttt ccaggcacac gatgtagctg caggtggatc 18780 taccattctg ggttctggat ggtggccctt ttctcacagc tccattaggc agtaccccag 18840 tggggactct gtgtgggggc tctgacccca tatttccctt ctttactgca ttggtagagg 18900 ttctccataa aggctccacc cctgcagcaa acttctggct ggacatccag gcatttgcat 18960 acatcctctg aaatctaggt ggaggtttcc aaacctcagt tctttagttc tatgtaccca 19020 caggctcaat accacatgga agctgccgag gcttggggct tgcaccctct gaaggcacag 19080 cctgagctgt gtaccttggc tcctcttagc catgactgga gtggctgggc accaagtcct 19140 aaggctgcac acatcagggg ggccctggac ccagcccagg aaaccgtttt tccctcctag 19200 gcctgtgatg ggaggggctg ctgtgaaggt ttgtgatatg ccctggagac attttcccca 19260 ttgtcttgga attgggctcc ttgttacttt tgcaagtttc tgcagccggc ttgaatttct 19320 cttcagaaaa tgggtttttc tttttacatt gtcagactgc aaatttccac actttttttt 19380 tttttgagat ggagtctctc tctgttgccc aggctagagt gcaatggcat gatctcggct 19440 cattgcaacc tctgcctcct gggttcaagc aattctcctg cctcagcatc ccgagtagct 19500 gggattacag gcacccgcca tcatgcctgg ctaatgtttg tatttttgta gagacaggat 19560 ttcaccatgc tggctagact ggtctcgaat tcctgacctc aagtgatctg cccaccttgg 19620 cctcccaaag tgctgggatt acaggcgtga gccactgcgc ccggccaatt tccacccttt 19680 tatgctctgc ttcctcttga atgctttgct gcttagtaat ttcttcccct agatgcccta 19740 aatcttctct ctcaagttca aagttccaca gatctctagg gcagggtcaa aatgctgcca 19800 gtctctttgc taaagcatag caaggatcag gagaacagca tgggggaacc gtccccatga 19860 tctaatcacc tcccatgatg tcccttccct aatatgtggg gattccaatt cagattacaa 19920 ttcaagatgg gatttaggtg gggacacaga gccagaccat atcagtaatc tcttgggcta 19980 accaataacc aatgtattct tgtatttttt ctttgaaatt ttataaatat ttataaattt 20040 aaataacatt taaatcaaaa tggattatgt tgtaatcatt actctgccag tttttttttt 20100 ttaattttta aatttatttt ttgtagagac aggatctccc tatgttaccc aggctggttt 20160 tgaacccctg gactgaatcg atcctccggc tttggcctcc caaagtgctg ggatcaaagt 20220 ttgttaattt gatagctaaa atatattttc atctgcattt caattacaat tagaagctat 20280 gtatcctgca acatattttc cagcaatttg tgtattttca gtgtgtcttt ctgagtcctt 20340 tttgggtatg cctggactag tttgtctttt tcctgttagt ttgtaagggc tcttgttatt 20400 gtgggacctt tcctctttgt ccatcacctg tattgtataa atattttgtt acaggctatt 20460 gttttcctat tggcatatta acatttgagt cttgttctta ctagtatgta gttttgcaag 20520 gttgcatttg tagcttgcat actgtctcct atgtttttat ttactgtaat aagtattttc 20580 ccatgtaccc acgtaacctt tttaattaaa cctataaatg tccaatcgat agttccctgt 20640 gttggtgggc tataatcaca taattattat ctgtggtttg acatttgggt tgctgtgttt 20700 tctttctcct tttttttttt tattattatt tttgagacgg agtcttgttc tgtcgcccag 20760 gctgaagtgc agtggtgcga ccttggctca ctgcaagctc cgcctcccag gttcacgcca 20820 ttctcctgcc tcagcctccc aagtagctgg gactacaggc acctgccacc acgcctggct 20880 aatttttttg tgtttttagt agagacggag tttcaccgtg ttagccagga tggtcttgat 20940 ctcctgacct tgtgatctgc ccacttcggc ctcccaaagt gctgggatta caggcatgag 21000 ccactgtgcc cagccccttt ctcccttttt aacttttttg agacagcatc ttataccatc 21060 acccaggctg gagtgcattg cgcaatcttg gctccctgtg acctctgcct cctgggttca 21120 ggtgattctc ctgcctcagc cgctggagta gctgggatta cacatgtgta ccatgatgcc 21180 tgattaattt ttgtattttc agtagagatg gggtttcacc atgttggcca ggctggtctc 21240 gaactcctga cctcaggtga tctgcctccc aacgtgctgg gattacaggc gagagccacc 21300 atacccagtc atttttattt ttcttttaaa gaaaacactg tcctgaatac cacatgggta 21360 gagtgcgtat tggcttattt ccttagatga tgttctcagg agtggaatga ataacatctg 21420 aaaaggcttc actctagcca ttgtcttatt ttctaaaagt gagctggccc agctcaccgt 21480 tctagcaggg tctaaggtta cttactgctg tggttattat tcagagtgga cgatggtgca 21540 tgttaatgtc aggcacagca gggcgcggtg gctcacgact gtaatcctag cactttggga 21600 ggccgaggtg ggcggatcac gaggtcagga gttggagacc agcatgacca acatggtgaa 21660 accccatctc tactaaaaat acaaaaatta gctggcgtgg tggcaggcac ctgtaatctc 21720 agttactcgg gaggctgagg cgggagaatt gcttgaaccc aggaggcgga ggttgcagtg 21780 aactgagatt gtgccactgc actccagcct gggtgacaga gagactttat cttaaaaaaa 21840 aaaaaaaaag tcaggctttt ctagggttcc tccatcagcc ttgtaaggct ggagacccgt 21900 ggccaggaag aaaattggag ctgtctggca ctgggaaggg taacccagta gttataatta 21960 ggttggctta tctgcgagcc ctttgataag gcttcactaa tttactaacc caggatcgca 22020 tgttagatca ggatctctct gagtgctgca attgtagttt gcttttctct ctctcttttt 22080 tttttttttt tagagacaga gactcactct gttgcccagg ctggagtgca gtggtatgat 22140 catggctcac tgcagccttg aactcctggc ctcaagcgat cttcctgcct taccctcccg 22200 agtgtcttgg attatagatg cttgtcaaca tgcccagcta atttttaatt ttttttagag 22260 atgaggtctt gccctgtcac ccaggctgga gtgcagtggc atgaacatag ctcactgcag 22320 ccttaaactt ctggcctcaa gcagttctcc tgcctcagcc ttccaaagtg ctgggattac 22380 aggtgggcac cactgtgcct ggcctgcagt ggtttaatag ggctctttca tctttaactt 22440 tggtcccctg ccccctgaga tccgtggagt gagccgtttg acgcttggta cttgggacaa 22500 agctggccta tgtccagttc tctgcatact tggtagggga gtgtttggag aaaaggctca 22560 cctctgagtc acaccctcta tattctccaa agggccatgg ggatggggtg gaggaggctg 22620 gggtgaagag atgttgtagc tccagagaaa gccagggagg tgtatgctgg gtgaagaggc 22680 caagttcagg agcctaggtt tgaaaatcag tatagacgat tcaggttaat tcaccctgtt 22740 gttatagagc atctgtctgt agggtggcca ggtctgggtg agtctcttgg acaagatggg 22800 tatcaggttt cagctctgaa attggactga tatgtgggga gattcattct gcagttttat 22860 ttgtagttta ggtttaagaa aacttggact gggcactgtt gctgtcgtct gatcccagca 22920 cttagtgatg ctgaagtggg aggatcactt gagcccagga gtttgagacc agcctgggca 22980 acagaaagac cccatctcta caaaataata ataataataa ttattattat tattattagc 23040 tgggcatgat gggacatgcc tgtagtccca gctactcagg aggctgaggc gggaggtttg 23100 cttggtcctg ggaggttgag ctgcagtgag ctatgattgc accactgcac tccagcctgg 23160 acaacagcat ggcactgtct ccaaaaaaaa aaaaaacaac aaaaaaaaaa cttgtttaac 23220 tacctaaatc atagcatttg tgtgaagcca gactatcaca actctgagaa ctgctgacat 23280 atacatattt tggaagttcc aggttttctg ttactataaa catggtagag attgaattac 23340 ttaaagggac gtcttttctc ctactctttg tcttgtctga tgttataagg ggtacagtat 23400 agaatgaaaa cagtgcagaa atgagtgaaa catgaaaatc ccttctagag ataattttct 23460 tttattattt ttttgagacg gagtcttgct ccattgccca gtctggagta cagtgatctc 23520 ggctcacggc aacctccacc tcccaagttc aagtgattct cctgcctcag cctcccgagt 23580 agctggggtt ataggtgtgt accatgcacc accatgcccg gctaattttt gtatttttag 23640 tagagacagg gtttgctgtg ttagccaggc tggtctcgaa ttcctgacct caggtgatcc 23700 gcctacctcg gcctcccaaa gtcctgggat taccggggtg agccaccatg gccagcctct 23760 tctagagaca atcttattgg caggttgatg tttttaattt tcagcctctc ttctccacag 23820 atcctaaaga tatagtaatt tttttttttg agacagagtc ttgctctatt acccaggctg 23880 gagtgcaggt ggcgtgatct ctgctcactg cagccttcac ctgccgagta gctaggactg 23940 caggcatgca ccactatgtc tagctaattt ttgtattttt agtagagatg gggttttacc 24000 attttggcca ggctggtctc aaactcatga cctcaagtga tccacctgcc gcagcctccc 24060 aaagtgctgg gattacaggt ctaagccacc gtgcccagcc ataaatacat ggtatttttt 24120 aagaacaaga acgggattct acaaaaacat atatatgtgt attttgagac aggatctcct 24180 ctgttgctca gggtggagtg caggggcacg atcatggccc actgcagcca tgacctctca 24240 ggctcaagca atcctcccac cttagcctct ggagtagctg ggaccacagg tgcccaccac 24300 catgcccagc taatattttt tctttttttt ttttgtattg aaaacagtca gccaggtgtg 24360 gtggctcaca cctgtaatct cagtacgttg agaggccgag gtgggcagat cacttgaggt 24420 cagtagttca aggccaggct gtccaacatg gtgaaactcc atctctacta aaaatacaaa 24480 aattaactgt ggtggcgctt gcctataatc ccagctactg ggaaggggga ggcataagga 24540 tcacttgaac ctgggaggag gaggttgtag agagccaaga tgatggcact gcactccagc 24600 ctgggcaaca gagcaagact ctgtctcaga aaaacaaaac aaaacatata gtctttattt 24660 ttttgtttgc gtgggctggt gcatcttgat tatgatgcat ttttgttaat tgatatttaa 24720 ttgcagatga aatgtaacat ggatctgagt aattgctgat aattgtttcc tctttaggca 24780 gctggtcagt cttttttttt tttttttttc tttttaagag agtttctgtc ttgttgccca 24840 gactggagtg cagtagcgtg atctcggctc actgcaacct cctttgccag ggttcgagtg 24900 attctcctgc ctcagccccc cgagtagctg ggattacagg catgtgccac cacgcccggc 24960 tactttttgt atttttagta gagacgggtt ttgccatgtt ggccaggctg gtctcaaact 25020 cctgacctca ggtgatcccc cctgcctctg cctcccaaag tgctgagatt acaggcttga 25080 gccactgctc ccagcccata gtcttttttt tttttaaacc tctgtgtaca ggtaggtcct 25140 ggggaaattc gaggcaagac ttgggtgagt gggtatctta gaccctctca ggagctcttt 25200 gcaggaggta gaatctccga gggtcagtgc ccatgaatgg gtcccatggc ctgactggtc 25260 ccattcaggt gacagtctct gagggtcctg catagccctt acctgggctc catgctggga 25320 atcgagcggt atacagagca tggttccctg ccttccttga gccccagtct tgttggggaa 25380 atggccaaat aaatgaataa tcatcaggaa gtgctatgaa ggggagctgc gtggtgcccg 25440 gtgagtgcaa tagcggggtt tcatctggtt ggagagaaaa aaggagactc cttaagtggg 25500 gaacccgttt gatgatacag gtttggctat gtgtgtcaaa gaccccaaat atagtgggtt 25560 aagatacaag ctcatttctc tctcatgtaa aaatcccagc tggtgtggca gctctgtccc 25620 caaaataatc agggtcccag gcccctccca tcttgttgct ctgctgtcct catctgcatg 25680 gatcaagatg atgcatctcc atgtccacat ggcagccagt aggaaagcag agtaagggca 25740 caacctggag gttgcctacg tctctcctcg tcacatccca ttggcttgta cctagtcatg 25800 tggtgcctct agctgcaaag gaggctggga aatgtagttt cctttctaag caggatgtac 25860 ccagctgaag atgttactca gggatgaggg agagttgata ctggagcgca gctagcagtt 25920 tctgctgtat aggcaaaagc agaaggtaag aatgttctgg gcagtgggaa atgcatgtgc 25980 agaagcactg gcttaatgag gaaggccact gtggctggag tcaaagagta gggaagagaa 26040 aaagaaccag aaggaggctg agaattgggc ctgtaggact tggatcctgt gggaagcctt 26100 ggcagctttc tttcccccct ccttgcttag gcattagctc taagacaggg atatttacaa 26160 cacaattatt tctttaaaat tatatatata ttttaatttg tacagatgag gtctccctgt 26220 gttgtccagg ttggtttcaa acccctgagc tcaagccatc ttcttgcctc ggcctccgaa 26280 agtgttggga ttacaggtgt gagccattat acctggcctt caactcagtc cctaaagaca 26340 actccttctc aagtgttgga aagaaccaat gactaatcac ttctagtctg ccttatcccc 26400 atcttgcttg tgtgactttg gtaagagttt gtttgtttat ttaaaggagc agagagttta 26460 ataggcaaga aggggcaaga aagaagggag aataagatcc cctgtataga gacggaggag 26520 ggctccaaag ctgagagagg gaaccccagc tgccacagat agcagctagg tatatgtaca 26580 gaggctggaa gaggcagtgt ctgatttgca taggcctcag gggattggtt tgactaggca 26640 tgtctttcac gtagcgcatg aaaaagctgg ccctcccacc tagcctttta atatgcaaat 26700 gcagggtacc atgatctgca cacttgggga ggtgtggtgg cggccatgtt gctaggaaca 26760 tgtggggaaa gggcaagaag gctgtgggaa tcgccatgtt tgggtggacc cagtttctaa 26820 tggcttgcat ttgcatatca aaggttgctg gcctggctct aagagccggg gctttacaag 26880 aaacttttcc ggagttgctt taaaaaccaa acatttccca aggacccctt ttcctctcta 26940 tttgcctaaa ataattgctt aactcctaca ttaccccctg tggagatgcc acattaactg 27000 ctgttagggg gttttgggcg acgacttctt ctggctactt cctggtgaaa aggggcgttg 27060 aatggggaac agcagctagg gctcctcctg gggtggatct aagggtcctc ggaagaatgg 27120 cgtgtccatg tgtgcttcag gttacagcac cattttgagt ttgattgctt cagtctgatg 27180 aaataatttc ctttcctggc caacacacca aaatgatacg gctccgatga gtgggggaac 27240 accagggttc ttggtcctca tgccggttta gataaaatga cacagacaca cgtggagtgg 27300 ttttaaggag tggagagttt aataggcaag aaggaaggga gaaggaagaa ggtcccctgt 27360 acagagacag agggtggggg gctccaaagc tgagagacgg aacctccagg agttgatttt 27420 ataaataaaa taacatgcgt tgaggtcact ctgtgttgtg tggtatgccc agccctctct 27480 gcacataact tgtttcaggc ccacagtcat gctgggtggt tgctgtaatg actttttatt 27540 ttaaatgggg aatctgtgac acagttaaac atgcgcagga tcatgtcact agcaaggagt 27600 ggacacggta ttcaaaccca gcaggttgac tcaaagcctg ccctttcccc agctgttttg 27660 cccctcagtc atttgagtct agtcttcagg attttgacat ctatctctta ccttgtatct 27720 gttaggattg catctggctt caagaaacag ccctacttca gcagcctaag cagaaaggta 27780 ttcatttgtt tattttttac atgtcaggaa ttccagtacc tcttggagtt gctggcattg 27840 gattagtgat gcagggttgt taggactgac atctctgctg ttttcttgtc ttttcctcaa 27900 ggcccctaaa tggctgctac agccctaggc aatatatctg ggttcaaggt aggaagaggg 27960 agggattgca ccagcctcat gggttccttt ctattcagga aagtccaagc cttcttcaaa 28020 ggctcttctg tccacattgc agacttctgg tcatgtctcc ttggctgaaa ctggattaca 28080 tgaccacctc tagctgcaag ggaggcagga aaaatgagca tttggtttta tgcttctcta 28140 ggaggaaaca gcaagggaga aacttttgag taagccagcc aatattgtcc aacatgtact 28200 tattttttaa cttttttttt tttttttttt ttttttgagg caaggtctgg ctggctctgt 28260 tgccgaggct agagtgtggt ggcacaatct cagctcgctg caacctctac ctcctaggct 28320 gaagctatcc tcccacctta gcctccagag tagctgggac taccacatgc accaccatac 28380 ctggctaatt tttatatttg tagagatggg gtctcaccat gttgcccagg ctgctcttga 28440 acttgtgagt tcaagtcgtc tgcccacctc agcctcccaa agtgctggga tgacaggcat 28500 gagccatcac actcagctaa tgtttttctt tcaatcaatt cactttttaa gccttaacaa 28560 agttatcgca aaaggaagtt tcatatcact ttagaatgtc tttgaagtca caggttggtt 28620 atatttatgt gcttacttta atagctatta aagtaaatat agcactacta agaaaaaaag 28680 atattcttta aatcgcctat tatcagtggt tcttaactct ggatgatttt gtctccaggg 28740 gacatttggc aatgtctgga aacatttttg gctgtcacga tggggcaggg agcgcacgcc 28800 tagagtctag tgggtagagg ccagggggtg tgctaaatat cctacaatac aggatgggct 28860 ccataatgaa aaatcctctg gtcccaaatg tcagtagtac tgcagttgag aaaccctggc 28920 atggacgcaa tccacctgct gccaggagtt atatacaagc catgttaggg taatgctgca 28980 atatgtccat cgtgattgtg ttttctcctg ggtgactatc agcaatggtg tagcctgctt 29040 gttggttttc aaggtccatt ctcaagatac tatcagatct ccagcaatcg tgtgatgcag 29100 tttaaaatgt tcatgtgagc tgggcgtggt gactcatgcc tataatccca gcactttggg 29160 aggccaaggc tggagaatgg cttgagccca ggagtttgaa accagcctgg gcaacatagc 29220 gagacccagt ctctacacaa aattaaaaaa aaaaaaaaat tagcccggta tgatggtgca 29280 tggccatggt cacagctact caggaggcag aggtgggatg atcacctggg cctgggaggt 29340 tgaggctgcg gtgagccacg attgcaccac cgtattccag cttgggtgac agagtgagac 29400 cctgtctcaa aaaaaagaat gtgcatatga attcaagata tgtcccttat agagactggt 29460 gaggacacag cttattgacc ctgaagctga agtggttgaa atgatagccc tcttgccagg 29520 caaatcctat gtgagtgctt ctaaaagaac actgtacctt gcagagagta ttcctgggac 29580 ctggcaggaa tcagggcctc ttggtgacca catgctttgg aaagggctgt gctttggcaa 29640 gtgggagatt ttattattta ttttctcctg tctgcctcgg tttggcaaaa acaaacctgg 29700 cctgggcatg ggccttgtgg agacaagaag gcagcttgag attatcagag atcaggctgc 29760 tggtgggttt gcctgagctg gcctggtcag gtagcttgac aatgatgctc agacccccat 29820 taaagttaat tgagcggtta cagagtggga gtggggagtg gggggtgtgg tgactgcctg 29880 tctccttgag ttggcgtggc taagaagtaa gggaattttt taacttttcc ttcttaattc 29940 tggaaactta gaaaaaagcc tctcaccatc ccttaatcat tcagttagag agaccaggct 30000 gttgatatgg acatgctgcg tttcatggaa tcctagaggc cagtatttat gacatacttc 30060 ccagtttcag agatgttagg atataaaaat gtagccagca gtgtttacag gatgggctaa 30120 tcgagagaca cagacaaata tcaaagatag caaaatagga agaaacagag tcttagaatc 30180 aatgcagtat aataatagct tctagtttct ttctgttttt ctttttatga tacagagtct 30240 cactctgtcg cccaggctgg actgcggtgg catgatctcg gctcactgta gcctccgtct 30300 cctgggttca agtgatcctc ccatctcagc ctccaagtca ctgggattac aagttgtttg 30360 ccaccatgcc cagctaattt ttgtattttt aatagagaca gggtttcacc atgttggcca 30420 ggttggtctt gaatgcctga cctcaagtga tcccccccag ccttggcttc ccaaagtact 30480 gggatgacag gtgtgagcca ccatgcccag cctccccctc actcttaagc acagctcttc 30540 ggcagtcaga gatgttgcct gctgtatttc tcgttctgct tttacacatg gtttaaaaat 30600 cctcgcccaa gaatgtaagc cccatggcta gtgctacctg ctacctttag gggtggcctc 30660 tcctggggtg caggaggttg cacagttcgt tttgtgacag cagggtcatt ttttaatcgg 30720 atcatctgcc ccagtttgct tggctcttag gtgcttggga gttctcctgg ttttttgctg 30780 ttgtgaaatg gcccagcttg tacacgttgt tccttttctt gctggagtta tttcctttag 30840 actcctgtcc ctaaagtagg attgttgggt gaaaatgggg tatgcgtggt taggcttttc 30900 tctgcctgct ttctggattg ctcttcagat agatttaatc accttttatt tatgttttgt 30960 ggtggttttt tttgtttttt ttgttttttt ttgttttgag actgagtttt ggtcttgttg 31020 cgcaggctgg agtgcaatgg tggggtctcg gctcacagca acctctgcct cctgggttca 31080 aacgattctc cttcctcagc ttcctgagta gctgggatta caggcatgcg ccaccatctc 31140 tggctaattt tgaattttta ttacagacgg ggtttctcca tgttggtaaa gctggtctgg 31200 aactcccaac ctcaggtgat ctgcccgcct cagcctccca aggtgctggg attacaggcg 31260 tgagccgcca cacctggcca ccttttattt gttgaatgag tgtttaataa gcatgtccta 31320 tatgcatcag gagaattaaa tggacatggt cttgctttgg ggggaaatga caggtaggag 31380 agaaagagac acttagaact caacagaggc cagacgcggt ggcttacgcc tgttatccca 31440 gcactttggg aggctgaggt gggcggatca cctgagatca ggagttcgag accagcctgg 31500 ccaaaatggt gaaatcccgt ctctactaaa atataaaatc aatcaggcgt ggtgatggca 31560 catgcctgtg atcccagcta ctcgggaggc tgaggcagga gaattgcttg aacctgggag 31620 gcagacattg cagtgagccg agattgcact actgcactcc agcctgggca gcaagagcaa 31680 aactctgtct caaaaaagaa aaaactcaac agagaaaagg cggatcgtta aggcttcttt 31740 ggcacttcct aagtgccagg gactgttgtt aatgcctttg aagtgctaat aatgacttaa 31800 tggtgacaag ttccctgtga agcagggact gtgattgttt ctaccttatg ggtggggaaa 31860 ggaggcagag agaggtgaag tcacccagct agtaaatgac aggactagac tgaaacccag 31920 gcagtctgtc tccagggcct ggccggtacc ccatgctcca tcttgcccca taaacaccct 31980 ggggtgggcc agagaggagt cttttccaac aggctgtgcc agatgacttt ggctaatctt 32040 ggaggctgga ggattagtca gtctactaag ggggcttcag cattttggca cgtggcttta 32100 tgagctgttt actccaacag tgatgatgac aatagccata gtagtgataa tactatggta 32160 gaagtaactg cagcaaactc aacccctaac gagtattcta tcttcccaac attgtgtgca 32220 atagccatga gagatgggtg ttattctttt aatttgacac acgggaactg aaagccagag 32280 agattgggtg gcttccccca ggccacacag cctggaagta gtaggacagg gactcgagcc 32340 cagatctgct gccccagagc ctgtgccctt gaccaccaag tcatggtcac tcctttcaac 32400 cctgcctgcc cctgggccat ctgtgttgtg atgccggctg gccaggatgg ggagtgagga 32460 tttcagtttg tcatagggca gggagatggg tgaggcagga cactccttga gatggaaggc 32520 tctggggtcg ggggagaggg agtggtggag actggggtgt ctccgaagga gtgtttgaag 32580 atgacggtgg tttttccagt ttcctgttct tagctatatt caagaaaagg gtaagccaga 32640 aaatttccct ctgagtttca caacttctgg gagcttttgc aaagtctggg tgatgcagca 32700 ttttcctggt ttgaatccta agtgaagttt cattttcctt cacttaactc attctggctc 32760 tggcctgtct tcccagctgt attggccatc tggtcctctt ctggctcttt gtcccattta 32820 ttattattta tttttatttt taacagagat ggggtctcac tgtgttgccg tctgttctgg 32880 aactcctgga cccaagtgat cctcctgcct cggtctccca aaatactggg attataggca 32940 tgagcctctg tggccagctt atacccccta agcttgtgac tatcttctat gtgtgtccct 33000 cttggagtga ggttccctcc tgtctccatg ttggcaaatc ttagcacctt ggcccttcga 33060 gatggaggtc tgtgttgcct aggctggtcc tgaactcctg gtctcaagtg atcctcccat 33120 cttggccttc cagagtgctg ggattacagg tgtgagccac tgtgtccagc caacccttct 33180 tagattttac ttacttcaag aagcctgctt tgacctctca agtggaaata acaacttcca 33240 ggaatagagt gatcactggg catccatctg ttgtcacatg aatgatttta tccatattaa 33300 ggaggcatta catgcagcag tgagctaacc tgcctgtgtt gaagttttct tctttttaca 33360 ggctgtacaa ccttgggcaa gttgctttac ttctctgtgc cttagtctct tcctcagcaa 33420 aatggaaaaa atactaccca tttcaaatgg ggtgaaaatg aaataatata taagtctcgt 33480 cttcacaatg tctctgatga aaagcaggta ttggttgcac atggtgctca tgcctgtaat 33540 cccagcactt tgggaggccg agcagggagg attgcttgag gccaggagct tgagaccagc 33600 ctggggaaca tggccagacc acatctctta aaaaaaattt agctaggttt ggtggcatgc 33660 acttgtggtt ctaactagtt tggagcaggt gaggagggag gatctcctga gctcaggagg 33720 ttgaggctgc agtgagctgt gattgcacac gactgctttc cagcctgggc aacagagtga 33780 aaccccatct caaacaaaca aacaaacaaa caaacaaata aacaaaaaac aggtattgtc 33840 cttgctgtat gaatgaggaa agtgagtttt cctttttgct ttgtgaaact cttttctgga 33900 tatttcttgc cttttatgtg tatctctttg gtggtactct gtgcttttaa aatcttttgt 33960 aatggccatt tatggacaaa tcgtatctta tattcaagat tctaagcttt ctgagggcag 34020 gatataaatg tggttgtttc tggttcaagt cctgatacaa gcaaagctca gtaatttttt 34080 taaatgaatg ggtgggccgg tggttgggtc ttcagagtca ctaaatactg gtggcaggag 34140 tgggaccaca tagaaaaaaa tattaaggca gtggatctca atggggagtg atctgcctct 34200 cagaggacgt tcattgatgt ctagagacat ttttgttgtc acagtttggg atgggggtgc 34260 agttggtgtc tgttgggtta ggatcaggaa tgctataaac atcctgtgat acacgggaca 34320 gacgtatcca gcctaaaacg tcagtagtgt tgagggtgag aaaccctggg cttattaagg 34380 caacaagcaa catattaata gcaacaggag aaaacatgca tttaaatttt ttttggccag 34440 gcgtggtggc tcacacccgt agtcccagca cttcgggggg cccaggtggg cggatcatga 34500 ggtcaagaca tcgagaccat cctggtgaac atggtgaaac cccatctcta ctaaaaatac 34560 aaaaattagt tgggtgtggt ggtgtgtgcc tgtagtccca gctacttggg aggctgaggc 34620 aggaaaatca ctttaacctg ggaggcggag gttgcagtga gctgagattg cactactgca 34680 ctccagcctg gagacagagc aagactctgt ctcaaacaaa caaacaaaca aacaaaaaaa 34740 aaacaaaatt ttttttccac aaatgtgaag tagtctagat gagatacgct cttcctgaga 34800 tgataaagtg aggtctaagt gtatttatta attcttttga ggagggtgtt aggtgctaaa 34860 ggcagcacgt gtaaggtgaa aattgcgtat agccaaaatg accctggggc ttattctctc 34920 tctctctctc ttttttaata aacagctttt ttgttgagat ataattcaca taccatatga 34980 tgcacctata aagtgtgcaa ctcagtttag tacattcaga attgtgcatg tctcctgtct 35040 ccaggtaggc aaatcttagc acctcggccc ttcttagatt ttatttttta gagatggggg 35100 tctcactatg ttgcccaggc tggtcttgaa cttcttggcc ttcctcccat cttggccttc 35160 cagagtgact atattcaata ttcaaagtga ctgtagtcaa cattagatat ttttatcacc 35220 ctgcttactt gtttttattt aagacctggt gtggtgtgtg cctggccttg tgatcacaaa 35280 tgctagttac actgaattga cattttgctg agactcgttc tgaggtccat tcatagatgc 35340 cctaggtact tcctgattac ttgccacacc ccaggaattc tgcacagtga gtggggagtg 35400 acattttgag ggacagcatc agtacattca ctgcgctaaa gaaacagtct ggggagagtg 35460 agacatcgaa aaaataacat ataaaataaa catctgatgg agacatagga agatgccaac 35520 cttcaacaat gtttgacttg gagcaggggt tggcatgctt tttctgtgaa gggttaggta 35580 gtacatattt taggtctctc aggcccaggg gcaaatagtc tttcttataa tatgtattta 35640 aaaattggcc aggcatggtg gcttctgcct gtaatctcag cactttgaga ggccaaggtg 35700 ggaagattgc ttgagcccag gagttcgaga ccagcctcag caacaaagtg agactctgtt 35760 tgtattagtc tgttctcacg ctgctataaa gaactgccca acactaggta gtttataagg 35820 gaaagaggtt taattgactc acaattccac agggctgggg agacctcagg aaacttatac 35880 tcacagcaga aagggaagca aacatgtcct ccttcacatg gtggcaggaa ggagaagtgc 35940 tgagcaaaag gggaaaagcc gtttatcaaa ccatcagatc ttgtgagaac tcactataat 36000 gagaacagca tggaggtaac tgcccccatg attgaattgt ctctcactgg gttcctccca 36060 caacacatgg ggattatgag aactacaatt caagataaga tttgggtggg gatacagctg 36120 aaccatataa ttccatggcc aaatgatatc gttctgcccc tcccaaatct catgtcctca 36180 catttcaaaa cacaatcatg cctttccaag tgtcacccag agtcttagct cattccagca 36240 ttaacccaaa agtccaattc caaagtctca tctgagacaa ggcaagtccc ttctgcctat 36300 tagcctgtaa aactgaaagc aagttagtta cttcctagat acaataggag tacaagcatt 36360 gggtaaatac acccattcca aatgggaaaa tttggccaaa atgaaggggc tgcaggcccc 36420 atgcaagtct gaaatccagt ggggcagtca tttcttaaag ctctgaaatg atctcctttg 36480 actccatgtc tcacatccag gtcatgctta tgcgagaggt gggctctagc tatggccttg 36540 ggcagctctg cccctgtggc tttgcagggt acagccccca tcaaggggct ttcacgggtt 36600 tgtgttgtga gtctgcggct tttccaggtg cacggtgcaa gctgtccatg gatctaccat 36660 tctgcagtct ggaggatggt ggccctcttc tcacagctcc actaggcagt gtcccaatgg 36720 ggactgtatg gggcctctgg ccccacattt gccttctgca ctgccctagc agaggttctc 36780 catgagggct ccactgctgc agcaaacttc tgcctggaca cccaggcatt tccatgcatc 36840 ctctgaaatc taggtggagg ttcccaaacc ttgattcttg acttttgtcc acaggctcaa 36900 taccacatgg aatctcctaa ggcttttgag gcttgcaccc tctgatggca cagcccgagc 36960 agcattttgg ccccttttag ccacagttga agcaactgga acaaagtgta ccaactccct 37020 aggcagcaca cagcaggggg gccctgggcc cggcctatgg aatcattttt tcctcctaga 37080 cctctaggcc tgtgatggga ggggctactg caaaggtctc tgacatgccc tggagacatt 37140 ttccccattg tcttggtgat taacatttgg ttccgtttta cttatgcaaa tttctgcagc 37200 aggcttgaat ttttccccag aaaatgggtt tttcttttcc gtcacatcat cacccttcca 37260 atgtttcaaa cttttatgct ctgcttcctc ttaaacactt tgttgcttag aaatttcttc 37320 tgacaatcat ctaaatcatc tctctcaagt tctaagttcc acagctcttt agggcaaagg 37380 caaaatgctg ccactctttt tgcttaagca tagcaagagt caccttggct ccatttccca 37440 agaagttcct catctccatc tgagaccacc tcagcctgga cttcattgtc catatcacta 37500 tcagcgtttt ggtccaagtc attcaataag tccctaggaa gttccaaact ttcttacatc 37560 ttgctatact cttctgagcc ctccaaactg ttccagcctc tgcctgatac tcagttccaa 37620 agttgcttcc acatttttgg gtatctttac agtagcaccc cactcccagt accaatttac 37680 tgtattagtt tgttctcacg ctgctataaa gaactgccca agactgggta gtttataaag 37740 ggaagagatt tagttggccc acagttctgc agggctgggg aggcctcagg aagcttgtaa 37800 tcatggtaga aggggaagca aacacgtcct tcttcacatg gcggcaggaa ggagaagtgc 37860 tgagcaaaag tgcttctttt gctgagaagt gttgagcaaa atcagatctt gtgagaattc 37920 actgtcacaa gaacagcatg gaggtaacca cccccatgat tcagttacct cccactgggt 37980 ttcttccatg acatgtgagg attatgggaa ctgcagttca aaatgagatt tgggtgggga 38040 cacagccaag ccatatcact gtctctacca aaaaaaaaaa aaaagccagg tgtggtggct 38100 catgcctgta tcccagctac tcatgaggct gagatgggag gattgcttaa gtccaggagg 38160 ttgagactgc agtcagctat gaccacacca ctgcactcca gtctgggcaa cagagtgaga 38220 cgctgtcaaa aaaaaaaaaa aaaaaaaagg aaatccattc ttagcctgtg tgctgtacaa 38280 aagcaggcag caggctgaat ttggcccaca ggctgtggtt cgccaactta tgacctatac 38340 aaatggcaat tcatatggtt catcctagcg ataactgtac atggtgtatt agatactata 38400 tagcatgttc atatcaaatg tcatataatg tataaggtaa catatacagt ataaaatagt 38460 gcctgagaaa tatttgatga aaaaatctga taagtactta gcaggcacag tacaaagtac 38520 catgaagttg ttaaatgggg gatcagggtg tttgagaaag gggtggggag ataggtgggc 38580 ctccctcaag aaggaatgtt tcaactgtga gctgaaggat gcccctgcat tgcatgtcag 38640 ggcagtgatg gggagaaaga ctccaggtag agggaaccca ctctgcaaag gccctgagtc 38700 atgaaggggt ccctggaaca gtgagttggg gctgaaccca caagctgcag ttgtggggat 38760 tgtgatccat cctgagagct ctgagaacct ggaatagttt tcagcgcagt gtgaagggac 38820 tggggctgtg ttttgaagat atcccctgtc tgcggttggg aggggagtca ggaaacctat 38880 ttggaggctg gggttttcac ccaggtcatg cagataagat ttattaggtg tggaatgaac 38940 tgagcaaatc acatgtcttc taatggtaca ccacactttt tttttttttt tttggttttg 39000 agacagtctt gctctgtctc ccaggctgga gagcaatggc atgatcacgg ctcactgtag 39060 ccttgacttc ccaggttcaa gcaatcctcc tacctcagct tccggagtag ctgggactac 39120 aggtgcccac taccatgcct ggctaatttt ggtattttta ttggagacgg ggtttcatca 39180 tgttggccag gctcctctct aacttctgac ctcaagtgat tcgcctgcct cagcctccca 39240 aagtactggg attacaggta caagccaccg cgcctggcct ttagtgatat tttaaagact 39300 aaattccctt agagatgcct gggtctgcat ttattgctac tgttctgttt ctcactgtgt 39360 gtcttgaggt catcaaaagt aacctgggcc ttttcccttg ttttctgcct cctctaggct 39420 tatgagccat taagcaaagc cggattggtg tgtgggtcag gctcttcatg ttttctttag 39480 cttaataagc agtttctaag ggaactcatt gtgtcattgt ttagaatagc aaaagatgag 39540 cagcctccca agtggcaatc agtaggggct gggtgaatac agtgggttcc accccttccg 39600 tggtagggtg ggatgcttgc agaaggacat aagacgagga agccctttgt gcacagatgt 39660 gcggcagcct ccaaggtcca gtttttaagt gaaaacgtgg agatccactt ggtatatttg 39720 gtatgttacc tctgtgtaaa aaagcagaca agtaagaatt acgtagttgt atttgctgta 39780 tttgtaagaa attccagagg gataaatgag aaactaaaag aggcaattgc atttgggcag 39840 agtaactttt tattgtttac cttgatatat actttttttt tttttgagat agagtctcgc 39900 cctgtcaaca ggctggagtg cagtggcgtg atcgtggctc actgcatcct ccgcttccca 39960 gtttcaagcg attctcctgc ctcagccttc tgagtagctg agattacagg tgtgtgcgcc 40020 accaagctca gctaattttt ggtatcttta gtagagattg ggtttcacca cgttggctgg 40080 gctggtctcg aacccctgac ctcgtgatct gcccaccttg gcctcccaaa gtgctgagat 40140 tacaggcttg agccaccgcg cccggcctat atatgtatta tataaacata tgcacacgca 40200 tgcatacgta cacacatata tattttttaa aaattgagtc atggccaggt gcagtgtggg 40260 tcacacctgt aatcccagca ctttggcagg tgaaggtggg aggattgcct gagctcagga 40320 gtttgagacc agcctgggca acatggagaa accccttctc tacaaaaatc acaaaaattg 40380 gctgggcgtg gtggcataca cctgtggtcc cagctgcctg gaaggctgag gtgggaggat 40440 tgcttgagcc tggtaggtag aggccgcagt gagccatgat cacgccactg cactccagcc 40500 tgggtgagag agtgagactc tgtcttaaag caaaaacaga gtcatatatt tcctattaag 40560 gtgaaattta aaaaataaat tcctatattc catcatcccc agcttctgcc attctaaagc 40620 attttcctaa gcagctccac tgtggatgta gcgggtattt cagaaaggca ttagaaatgc 40680 cctgggaggg cagaacccgg ggcttcactg gaggtgctgt tgggctcagt ctgatgtcaa 40740 ggcagggaca tggcaagggt attgagatgt gaacaagcat tactcagcaa ggtgacatgt 40800 gttcatgcct tgatacactt gtttccccac cagctctatt tttgttgcct gctctattgg 40860 tttctttttc tttttttttt cttttgagac tgagttttgc ttttgttgcc caggctggag 40920 tgcaatggca ccatctcggc tcactgcatc ttccgcctcc tgggttcaag tgattctcct 40980 gccccagcct cctgagtagc tgggactaca ggtgtgcacc accatgccca gctaattttt 41040 atatttttag tagagacggg gtttcttcat gttggtcggg ctggtctcga actcctgacc 41100 tcaggtgatc ctcctgcttt gggctcccaa agtgctggga ttacaggtgt gagccactgt 41160 gcccagtctc tattggtttc ttattgctgg tattgccatc aacttggtga ctgagaacaa 41220 cacacatcac tctagttctc gggagtcaga ggtccaaaat gtacggctgg tgttctttcc 41280 ggaagcttgc agggagaatc catggcctgg ccctgtccag catcaagagg ccacctgtct 41340 tcctcaattc gtggtttcat gtccctccac ccctgcttgt gttgtcaaat ctcctttact 41400 ttttttttat ttttgagacg gaatctcagc tcactgtagt ctctgcctcc caggttcaag 41460 tgattctcct gcctcagctt cctgagtagc tgggattaca ggtgcatgtc accatgcctg 41520 gctaattttt gtatttttag tagagacggg gtttcaccat gttggacagg ctggtcttga 41580 actcctgacc ccgggtgatc tacctgcctc agcctcccaa agtggtggga ttataggcat 41640 gagccaccac gccctgcctc aaatctcctt ttctgactca gatattccca ccgtcctctt 41700 gtcccttata attccctgtg attacattgg gcccacctgg atcatctagg acaggggtcc 41760 ccaactcctg ggccatgaac cagtagcgag cagtctgtgg cctgttagga actgagtcat 41820 gcaacaggag ctgagtggcg ggcaagccag cattaccacc tgaattccac ctcctgtcag 41880 atcagtggct gcattggatt ctcacaggag cgtgaaccct aacgtgaacc gtgcatgcga 41940 gggacctagg ctgtgtgctc cttatgagaa tctaatgcct gatgatctga gggggaacag 42000 tttcatcctg aaagccaccc cccgccatcc ctggcaaaac tgtcttccat gaaatccatc 42060 cctggtgcca aaaagcgtgg ggacctctga tctgggacat tctccccatt ccaaagtcct 42120 taatgatacc tgcagagtcc cttttgccat gaaaggtaag agactcaggt tctggggacg 42180 gggatgtagg catctttacg ggctattctg tgtactgcac ctgttcagct tagttccagg 42240 cacatagtag gggctcagta catctttgtt gaatgacaca atcaatcatt tggttaggct 42300 agagaatgtg gaaggaggcc gggtgcagtg gctcacgcct gtaatcctaa ggctgaggca 42360 ggtggatcac ttgagctcag gagtttgaga ccagcctgga caatgtggcg aaaccccatc 42420 tctcctaaaa atagaaaaat tacctgggtg tgatagtgtg tgtctgtagt cccagctact 42480 caggaggctg aggcgggagg atcacttgag cccagaaggt ggaggtttca gtgagctgag 42540 atcatggcac tgcagtccag tctgggcaac aaaacgagac cctgtgtcag aaaaagagag 42600 aatgtggagg gatattatag caagaagtgg atctggaagt tttactagta gtggtattta 42660 ttgagcacct actgtgtgct ctggctcatg tttaacaaag tgcttatttg cataatgtta 42720 gtattcccat tttacagatg cggaaactga ggtttagttg ctggcctagt attacagggt 42780 gaggagctga agccccatct gcctgacgag gggtgtgttg gggatgtgga ctagaagctt 42840 ggtcagggag ggattctgtt caaacagggc tgcttagctt tggcactgtt gacatttggg 42900 gccagatatt tcccgtcgtg ggggctgtcc tatgtattgt ggccattaag cagtatccct 42960 ggcctctgtc cacagagtgc caatagcact accctcttcc taagttgtga aaacccagga 43020 tgtttccaaa tgttgtcaca tgtcccctga gtgacaaact tgcccccact tgagaaccat 43080 ggtgttgaaa catagatcac ggcacatcaa ctccatgctc ctcaggtcac cctgcgtgaa 43140 agtcagaatc cctgcggtgg cctgtgcgtc ccgcactgac tgtctcctcc ctgccttctt 43200 ccttcctcgc tgtcttcact gcttgttatt cttcagacct gttggcctct ctgcggtttc 43260 tcagaaatgc caggcctggt ctgacttcag gacctttgca ctggctgttt tctctgcttg 43320 gtgtgccctt cctccagatg gccatttggt ttactcctct gtttccttcc atcctgtatt 43380 tgtttattta tttttaattg agatggagtc tcgctctgtc acccaggctg gagtgcagtg 43440 gtgtgatcgc agatcactgc aacctccacc acccaggttc aagggattct cgtgcctcag 43500 cctcctgagt agctgggatt acaggcatgc actaccacgc tatgttggcc aggctggtct 43560 tgaactcctg gcctcaagtg acccacttgt cttggcctcc caaagtgctg ggattatagg 43620 tgtgagccac tgtgcctggc tcaatcctgt atttaaatac ccgtcctcag caaggcttgc 43680 cctcttctct gagtgctttt catcacacat gtcttcatat cctctccttt ctaaaccatc 43740 tgtctcttct ctttaggctg tcagctccag gagggccggc ccttggtccc tattgttcac 43800 tgctgggccc tcagccctag gaaccgtgct ctgtaaatgg atgaatgctg tctgtcctgt 43860 tactgcagtg tccccagaca tatccctatg cccagcacat gcctgacccc tcacaagacc 43920 ctggaacatg actaagggat ttatttggtg aaacatgaga gtctgataag aggagaggaa 43980 gtggctgggg agcaaccttg caaagatagc cagggttgga tggagaaaac gagggtgagt 44040 gtcagcttca taggacgggc cttccacgag aggcctcatg gtgcttggga gagttggggt 44100 gaaagcaggt tggaacaaga tgcttgctgc tgacatttgg gcactgatgg gcagcctgac 44160 ctctgctttc tttttagtgc ttaacaacac tgaagccctg ttaagacagg attcttagga 44220 ctgggcacag tggctcatcc agcactttgg gagccctggg tgggaggatc atttgagccc 44280 caggagtttg aggccagaca gggcaacata gcaaggcccc atctctggaa agaaatacaa 44340 aaattaacca ggcttggtgg tgtgcacctc tagtcccagc tacttgagag gctgaggtgg 44400 gaggatcact tgagcctggg agttcaaagc tgtaatgagc tataatcatg acattacact 44460 ccagccgagg agacagagca agactctgtc tcaaaaaaaa aaaaaaaaaa aaaaaattag 44520 ttttgcatgt aactgtgttc agttctgtgt cttggacgtg aggatttgtg gtacccgcct 44580 ggatagagca aggatggccg tgcccctgcc ttcctgggtg atggggataa gtctggaaat 44640 tgcccctgtg atgttactgg gctttattct tagctctgct gagttagggg gcagggtggg 44700 gtgcagccca gccaacagca tgccagggcg cgtcactgcc cacgcgatgc tggcttcagc 44760 cgccttcctc tcacctcatg gccctgccag ccgtgcttgc ctcctgctgt gtcggggctg 44820 ggagacttta gcctttctcc agatgttttc aggagtgcgg tggggaaatg aaggccacat 44880 gctgtctctc taaacaggat taatgttcag aagcccagcg ggtgccctga cctaaccacg 44940 ggcctcttgc actccttttc tcagcttccc ttggcttctg agctacccct ctgcagcgtt 45000 gtttctgagt gtggcattta ggagcaccct gtcgtcttgc ctttcgtccc tccaagcccc 45060 gtctgttcct tggttggttg tgcagaagag ttgctagggt ttgaatccag gacggtcctg 45120 cccctgtgac tcgcgggcca tcttctcacc tgtttgtctc tgtgttcctc tctgtaaaag 45180 tgggaatcat tacagtacct tcctcataga ctgctagggt gataaaatgg agcgatgtac 45240 atgaaacctg aacgcagtgc ctggtatgca gtccgtgctt agacagggct ctggttttat 45300 ttttatttct ttttctttga gacttggtct cactctgtca cccaggctgg agttcattag 45360 cataatcacg tctcactgca gcttcccact cctgggctca agcgatctta ccacctcagc 45420 ctcccaagta ggtgggatta caggtgtgag ccactgtgcc tggcaccatt cagcaatttt 45480 tttttgtttt gtttttgaga cagagcctgg ctctgtcacc caggctggag tacagtggtg 45540 cgatctcagc tcactgcagt ctctgtcttt caggttcaag tgattctcct gcctcagcct 45600 cccaagcagc tgggattaca ggcgtctgcc accacaccca gctaattttt agtagagaca 45660 gggtttcacc atagtggcca ggctggtctt gaactcctga cttcaagtga tccaccctcc 45720 tcggcctccc aaagtgctgg gattacaggc atgagccatc acacccggcc atcagcaaat 45780 ttttaagtat acaatatagt attgtgagct atagacacta ttctgtacag tagaccgtag 45840 gactgactga ctcatcttgt atgaccaaaa ctttatacgc tttgaccaac acctccctgt 45900 ttcccccacc accagctcct tgcaactacc attctgttct ctgcttctat gagtttgtct 45960 tttttagatg tcacatgtga gtgagatctt gcagtgttcg tcttcctgtg cctggcttat 46020 ttcatttagc ataatgttct ccaggcgcat ccatgttgtt gcaaatggca ggatttcttt 46080 cctttttttt ttagacagag tcttgctctg tctcccaggc tggagtgcag tggcacgatc 46140 tcggctcact gcaagctccg cctcctgggt tcacgccatc ctcctgcctc agcctcccga 46200 gtagctggaa ccacaggtgc ctgccgccac gcccggctaa tttttttttt tttttttttt 46260 gcatttttag tagagatggg gtttcaccgt gttagccagg ttggtctcga cctcctgacc 46320 ttgtgatccg cctgccttga cctcccaaag cggtgggatt acaggtgtga gcgactgcgc 46380 ccggccagga tttctttcct ttttaaggct gagcgatagt ccatggcatg tatagatcat 46440 gttttctttg tccacttgac cacggataga catttagttg tctccatctt ggttgctgtg 46500 agtgacgctc cagtgaacac gggagtgcag atatctcttc agggcccatg tgtggctgag 46560 attaggagat cactgctgtc gtctctagtt cagcagtgct agtgcctcct ggcgtttagc 46620 gtccagctca agggagtgga atttgggtgt ctcagggtct agggccacct gtgcctctaa 46680 atcgcaggga agctttgtgt gtgtgtgtgg tggggtgcgg ggggctatgg gtatgtggtg 46740 gggtgaatct tatttctctt ctttcccttt tcttaatttt ccgttggcaa aacagagcgc 46800 cactccagac ccctttcatt cttgcaatat acatgaaaag tacagggctt gttctgcaaa 46860 agaagagtag ccccagcgag ctcagggttg agtgaagttc cgcaaggatg gcacctctcg 46920 gctcttctgg gggcttcagg acagagctca gtgtcgccaa gcaggacccc cactgcgggc 46980 ggagctgcag ggccatcaac attcattagg tggatcagtg aatgtagact ctgcggtgtc 47040 acaaagcagc acctgtactc actgtgcctg tctcgggatg gaatctaagt cagacatcct 47100 tgcatcccca cttatgggct gttccttcac cttgctggtc ctcacctttc tcctagagtt 47160 acggggagga gtaaatgtgc taaggccata cacgccgact ctgcagtggc cttgaaccat 47220 gcttctctgt cacccctttc gttgccttga caatggctgc agcctccttt cccatctccc 47280 ctaggatctt ctcctagggt ctcttaatac aggggtcccc aatccccaga gcacggactg 47340 gcaccagttc atgcatgccc tgttaggaac caggccacag gccacacagc aggaggtgag 47400 tggcaggcga gcgtgtgaga cttcatctgt atttacagcc gctccccatc ttttgcatca 47460 ccgcctgagc tctgcctcct gtcagatcac ctgtggcatt agattctcat aggagcgcga 47520 accctgctgt gaaccgtgtg cgcgagggat ccaggctgtg tgcttctttt gagaatgcaa 47580 tgcctgatga tctatcactg tctcccatca cagctgagat gggaccatct agttgcagga 47640 aaacaaactc agggctccca ccgattctac ataatggtga gttgtataat tatttcatta 47700 tatatgacaa tgtaatcata gaaataaagt gcacaataaa tgtaatgcac tcgaatcatc 47760 ccctaccctg tctgtgaaaa atcgtcttcc acaaaaccta tccttgctgc caaaaagggg 47820 atggctgtct ttttttcttt tgagatggat tcttgctctg ttgcccaggc tggagtgcag 47880 tggcacaatc tcggctcact gcagcctctg cctcccaggt tccagcgatt ctcctgcctc 47940 agcctcctgg gtagctggga ttataggcac aatggcaccg tgcctggcta atttttgtat 48000 ttttagtaga gacggggttt taccatgttg gccaggctgc tctcaaactc ctaaccttgg 48060 gtgatcctcc cgcctcggcc tcccaaagtg ctgggattac aggcgtgagc cactgtgcct 48120 ggccagggac cactgtctta atatgtgaat taggcgatgc catgaccctg cttaatgcac 48180 tcccagggcc tcctgtgaga attagaacaa aaaatccatg ctctgtacca tgcctccaag 48240 attggctatg tggtggcctt tggtgacttc tcccgcccaa tcttgggtcc tagctcattg 48300 gtgcagccat atcctccccc caccccaccc cactgtggcc tttgcctgtg ccatctttct 48360 gcctggtatg tgcttcccga gatctttgca cagccagctc ttcctgaccc ttccagtctg 48420 ctaggatgtc atctgcccag accgccactc tggtgcttcc tgtcctgaca cccctgctct 48480 ttccttcaca gcaggtactg ctctttgtca ttatgttctt atctgtgagc tttcatcttt 48540 gatggactat gagtcttaag aggacagaga tatcgtttct gattttcccc catgcctgtg 48600 actagcccag gtctaggcat atagtaggtg ctcaataaac agtcatcgaa tgatagattg 48660 aatgaatgaa tgcatgacag gaaccctgca cttatctgtg ttaatccgtc tcttggctgc 48720 cgggaacacc agctcctgca acctggcact tgggtcacct gattgaaccc tcctgataac 48780 tctctaaact ctgtaatagg tgggttctag aattagtccc atttcacaga tgaagaaatc 48840 aaggcctggt gaggtgaact gacttgcttt agggcagcag ggatgatttt tgcctctctg 48900 gagatatttg gcaatgtcta gagacagttt tgattgtcat aacttgagga ggtggggagt 48960 gctactatca tctagtggca gaggccagcg acgccactca gtatcttaca atgcacagga 49020 tggcccccga caaccaagaa ttatttgggc tcaaatacca gcggttctga ggttgaagaa 49080 gccctgcttg agggcacaca tctgtaagtg gtggagacgg gaacctagac ctggaacctt 49140 gttttgttaa ccactaccct gcactgctca catgcggggg tgggtgggtg ggaagagttg 49200 tagaatgttt ccatgtctga gtcaaaatct tgcttctctg ctctagggag atgaatttgg 49260 aatctgtgag gcctgaggcc attcacttga tctccggccc tggagatctt gcctccaagc 49320 gacctcaggc tccatctgtc tgccatgtac cttgcaaaca ccttagaatt ctggctgggc 49380 atggtggctc acacctctaa tcccggcact ctgggaggcc gaggcgggca gactgagttc 49440 aagaccagcc tgggcaacat ggtaaaaccc tgaatctaca aaagatacaa aaattagcca 49500 ggcatggtga tgcgtgccag gtagtcccag ctacttggga ggctgaggca ggaggattgc 49560 tggagcccag gagatcgagg ctgcagtgag ctgtgatggt gccagtgtac tcaagcctgg 49620 gcaacagagt gagaccctgt ctcaaaaaac aaaaccagct gaccaaacaa accaaaaggc 49680 cttagagttc aagcacgtgg tttagaggtg gtggatctca gtgtcagact ctcagtgggt 49740 tcaaatcctg gccctgtttc ttctaggttg acgagcccaa gcaatttaca taaactctct 49800 ggacctcaga gcccttgcca ggaaagggga gagttttaat agtcctgact ttgtagggct 49860 gttggaaagc ttaaatggac tgtgcttggg aagcacttaa tcactgtgcc tggcgtgatc 49920 actctggctg ttattattgg cacccaataa atacatgctt tctctttgtt tccaactcag 49980 catttagaaa tgtcctaccc ttcaattcct gctgctattt atttatttga agtgcgaact 50040 agctttctta ttattatttt agaaatcatg cagaggagaa aattcaaaca gtacgaaaga 50100 taatacaaca aaaaatagta gttgccttcc tctccctggt ttcaggccta ccccctgcag 50160 attaattagc tttttttctt tctttttttc ttttcttttt tttgcaatat gaagtcttgc 50220 tctgttgccc aggctggagt gcagtggtgt gattttgact cactgcaacc tccgcctcct 50280 gggttcaagc aattctcctg cctcagcctc cctagtagct gggattaggg cagatcatga 50340 ggtcagaaat gtgacaacag cctggccaac atggtgaaac tccatctgta ctaaaaatgc 50400 aaaaattagc caggcgtggt agcaggcgtc tgtaatccca ggtacttgcg aggctgaggc 50460 aggagaattg cttgaactcg ggaggtggag gttgcagtga gccgagacca caccattgca 50520 ctccagcctg ggcaacaaga gcgaaactcc gtctcaaaaa acaaacgaaa catcaaattc 50580 ctgactgtgt atgctgcttg caggttatat atgaccaggc ctggttctgt atctgtaaaa 50640 tgggttacgt tatagtacct gagtcctaga gttgtgtgtg aggatgaaat gtaatgtgaa 50700 acacttagag tggtgcttgg ctgatgcaac taatgaatct tccctcttac tctttctata 50760 gacagaagaa ggcggcacag gtttcttcat tgcttttcgc cctttgctga aatgtcatct 50820 tggcccagag gccctttctg tctacctgat aaagaactag cacctgccca cccaccatta 50880 tgcttcaccc actttcttct tcttcaagcc atttgctccc attgggcata catagagttg 50940 ttttttttag ctgttggtag ttttggccgc tttgcataaa gtgaaattgt gtgagagtgg 51000 agactttatt ttacttccac atgaccttgg cccatggtag tagtcgctga taaatgtcca 51060 ctgagcaata agaacccgac tgttgcaagt tacttattta tttatttttg agacagggtc 51120 tcagtctttc acctaggctg gagttcggtg gtgcagtcat agctcactgc agcctcgaac 51180 tcctgggctc aagggatcct ccttcgtcag cctctggagt agctgggact aaaggcaaac 51240 gtcatcacat ctggctactt ttaaattttt ttatttgtag aaggtgggga gtctcactcc 51300 attgccacct ctggtctcga actcctgggc tcaagtgatc ctcctgcctc ggtcccccaa 51360 agtgttggga ttacaggtgt gtaccaccac gcccagctaa gttttttttt tttttttttt 51420 ttttttgaga tgcagtctca ctcttttgtc caggctggag tgcagtggcc tgatctcggc 51480 tcaccacaac ctccacctcc tgggttcaag cgattctcct gtctcagtct cctgagtagc 51540 tgggactaca ggcgcacgcc accatgcccg gctaattttt gtacatttag tagagagagg 51600 gtttcactat gttggccagg ctggtctcga actcctgacc tcatgatccg cccgcctcag 51660 cctcccaaag tgctgggatt acaggcgtga acccctccac ccggccagct aagtttttaa 51720 atttttttgt agagatacag tctcactgtg ttgcccaagc tgatctgaaa ttcctggcct 51780 caaactatcc tcctgcctct gcctcttcaa gtgctgggaa atataggcat gagccactgc 51840 acccagctgg ttgtgagtta ttgagatggt tgaattggga gtggatgctc aggcctcagt 51900 ggaacttgtg gtacacagta tgtcctcatt acctcccatc agtggcagtt gagattcata 51960 atcacttttt ctgcctgttg tctgccccat cctctctgtg gccttccctc ctgtcctgga 52020 gttggctggc tgggtccctg gcagggctgc atgcgttatc cctgcaggcc tgcttgcctt 52080 atccctgcag gccctggtgg agcatctgtg cagaacctgt gccatccaga tgggagcagt 52140 aagggtgtag ggcaaagtta gtgagctgcc cggtgcacga ggacttccat gataatcagg 52200 gctgaaccag gaaggcaggt caaggccagg gtcatgtaca gaaaggaggt cagcaccagg 52260 atcttgtatg ggaagactta gatcaatgcc tagtgcctta gtcatcatca ttcagcccag 52320 aaaacatgac gctatgcaac aggaatttta tgaacacaca aaggtcaggg gccactcgga 52380 cttggacggg gtccccaact ctttgagtgt cagggctgag ggcatggaga cacaacttga 52440 tcaagctggt gaagtgtcca gcaaggagaa gcctctgttg gagggagccg ggagctgggg 52500 aggacatgcg ctttctcttt tttttttttt tttgagacgg agtctcgctc tatcgcccag 52560 gctggagtgc agtggtgcaa tctcggctca ctgcaacctc tgcctcctgg gttcaagcga 52620 ttctcctgtc tcagcctctc acgtagccgg gactcaggcc tgtgccacca cgcctggtga 52680 atttttttgt atttttagta gagacggggt ttcaccatgt tagccaggat ggtcttgatc 52740 tcctgacctc gtgatccacc tgccttggcc tctgaaagtg ctaggattat aggcgtgagc 52800 caccgcgccc agccgacttg cgctttctct gtaaagattt ctgtgggcca ggttccccaa 52860 agggcaggcc ctgggccagt gcagtgaccg gtgaccgtgt tcaggactca tctcttgtgg 52920 ctgaattgtg tgtctggaga gttgggtcct tctgattctg ctcagagcgt ggtgggcctg 52980 gctggatttc cctagattag gaagcagcct cgggtagctg tgattctttg agttgggaac 53040 agcaagtggc ctgcagactg ccagggaatc gtcccttcct tgagccttta ggtattgccc 53100 attattcacc gtttttccca gaagcctcca gtagtgagag tcgcacttct tacctcctgg 53160 agttgttaaa gtaaagaagg acacattagg gtccctgccg gtaaggaaca tccaggaggc 53220 ctcgatacct tttttttttt tttttttttt tccctgagac agagtctcgc tctgtcaccc 53280 aggctggagg acaatgacct gatctctgct cactgcaacc tccacctcct gggtttaagc 53340 gattcttgtg cctcagctgc ccgactagct gggattacag gcatttgcca ccatggctgg 53400 ctaatgtatt ttttttttct ttttcagtag agatggggtt tcactatgtt ggccaggctg 53460 gtcttgaact cctggcctca agtgatctgc cctcctcagc ctcccaaagt gctgggattt 53520 caggtgtgac ccactgcgcc cagtcccgat actttgtttc tttgagacag tctcttactc 53580 tgtcacccag gctggagtgc ctgggtggga cgatcaaagc tcactgcagc ctcaagcccc 53640 taggctcaaa agatcctccc acttcagcct tctgagtagg tgggactaca ggcctgcact 53700 accacgcctg gataattttt aaattttttt ggtgaagaca gggtcttact ttgttgccca 53760 ggcttttctt gaactcctga gctcaagcaa tcctcccgcc tcagcctccc aaagtgctgg 53820 gtttacaggc gtgagccact gtgcccggtc ctcagatgat cttagctttg tgacctatgc 53880 tgttggccgc tgtaggggct gtgatggagg tgatgtgggg gtggatggca ggggtgaccc 53940 gtgttggctg ctttctgtaa cagtcatagt tcatggtcag agtcagattt cctctcgtca 54000 tgccttcctt cccttccttc tgctccctcc cacagccgcc ctttgggtct gggctggcca 54060 tctggctctg agcaggaagc tagcctgtgc tcttcaattt gctttctgca ggggaaacac 54120 cttcctttgc tcagcgtttc ctgacctctc cttccctgga gttccggtgt ccttaaatgc 54180 tctctggttt cttctgtagc ttactttctt gcttgaaagg acaacttttc tttgtccttt 54240 agacttctta tctctgggca atacagtggt ggtggcagtg gtgattatta tcaactatta 54300 gtatctgcta ctacggttta ttgtctctag actgtatcag cacctgtcac acattgtccc 54360 attgaatcct ctccagaact cttccaaatg atgtgttttc ctgactttta aaaaaattaa 54420 aaaaaaattt ttatattttt ttgagacgga gtctcgctct gtctcccagg ctggagtgca 54480 gtgctgcgat ctcggctcac tgcaagctct gccttctggg ttcatgccat tctcctgcct 54540 caacctcctg agtagctggg actacaggtg cccgccacca cacctggcta atttgttttt 54600 taatattttt agtagagaca gggtttcacc gtgttagcca ggatggtctc catctcctaa 54660 cctcatgatt ctcccacctt ggcctcccga agtgctgggt ttacaggcgt gagccactgt 54720 gcccagccaa aaaaattttt ttaaagaaat ggggtctcgc tgggtgcgat ggctcacgcc 54780 tgtagtccca gcactttggg aggctgaggt gggcggatca cctgaggttg ggagttccag 54840 gacagcctga ccaacatgga gaaaccccat ctctactaaa aatacgagat tagccaggcg 54900 tggtggcagg cgcctatagt cccagctact cgggaagctg aggcaggaga ctcgtttgaa 54960 cccgggaggc agagattgcg gtgagctgaa atctctccat tgcactccag cctgggcaac 55020 aagagtgaaa ctccgtctca aaagaaaaaa aaaatagaaa aagaaaaata aaagaaatgg 55080 ggtctcactg tgttgcccag gctggtctag aattcctggg ctccagctgt cctcccattt 55140 cggtctccca aattgctggg attaaatgtg tgagcctctg tgcccggcct ctttctctct 55200 ctctctctct ctctctctct ctctctctct ctcctctctc tctctctctc tctctctgtc 55260 tctttctttc tttctttctt tctttctttc tttctttcag cctgagtctc gctttgtcgc 55320 caggctggag tgcagtggca cgatctgggc tcactgcaac ctctgcttcc caggttcaag 55380 tgattcttct gcctcagcct cccgagtagc tgggactaca ggtgcatgcc accatgcctg 55440 gctaattttt gtatttttag tacagacgga gtttcaccat attagccagg atggtcttga 55500 actcctgatc tcatgatctg cccgcctcgg tctcccaaag tgttgggatt acaggcgtga 55560 gccaccgctc ctggccttcc ttttttttga agcaggttct cactctgttg cccaggttgg 55620 agtgcaatgg tgtgattatg tctcactgca gtgtctacct tccaaggctc aggtgatctc 55680 ctgcttcagc ccactgagta gctgggatta taggcgagtt caccatgcct ggctaatttt 55740 tgtgtttcta gtagagacgg gtttcaccat gttgtccagg ctggttttga actcctgggc 55800 tcaagtgatc cacccgtgtc ggcctcccaa agtgccggga ttacaggcat gagccaccgt 55860 gtccagcttt tctgactctt tttacttatc aggagactga agcttggaga aattaagtga 55920 cttgcccaag ttcacatggg gttaaggcct gaatttgaat ctacatctgc tcaattagga 55980 agtgagtggt catagctagt ctctacctgg atggattgtt gtttaattgt taaatttttt 56040 caaaataatt ttaaattatt ttattaaaaa agagggtatc attatgtttc ccaggctggt 56100 cttgaactcc tgggctcaag tgatcctcct gccttggcct cccaaaatgc tgaggttaca 56160 agtgcaaact actgtgccta gccagattat tacttaacaa ccaaaacaaa ggaggaaatt 56220 gacggtggac aagtaagaag atcattgcaa aggttggggg caggttgttt ggggagtgtg 56280 gaggaagctt tttaaatgag gtacctgagt tggattttga aggatgaata ggagtttgtt 56340 aggacagaaa gacattgcag agagaggatc tagcaagagg tgactgaaga aaccatttat 56400 ttgaccagca gttggggaat gccttgaagg caggaaccac agcctttcag aatctccagt 56460 gcctgcaaca gtgtctagaa cattatctga caacaagctt ggtaaatact tctttaagta 56520 aatgcctgag taaggcacat ttggggaaca gggtgggaga aattgtagga gaagtagatg 56580 ggacttgaat gtagaaggaa ggcctcatgg atcactgcaa gggttggtta ttttttttta 56640 ttttttatgt tttgagatgg agtctcgctt tgtcgcccag gctggagtgc agtggcgcga 56700 tctcggctca ctgcaagctc tgcctcccgg gtgcacgcca ttctcctgcc tcagcctctc 56760 caagtagctg ggactacagg cgcccgccac cacgcccggc taattttttg tatttttagt 56820 agagacgggg tttcactgtg gtctcgatct gctgacctcg tgatccaccc acctcggcct 56880 cccaaagtgc tgggattaca agcgtgagcc accgcgccca gccagggttg gttcttaaaa 56940 gccaataggg agccatggga agttgtttcc cagcagaaga gagaaggcca ttagatctgc 57000 cctatttatt aatgcaaata tctaagtcta tgaatcttcc tctgagcagg aaaacgtgat 57060 tgcttttaaa tccatatgga aagaccctca gttttactca tgataaagag aaaaggaact 57120 taaactacac agagatattt ttcacttcag attggcagag gtcggaaact tgttatctgc 57180 tgtgctttgt gaagtaattg cctttgtacc ttatcagctg gagtatgaat tgatgttccc 57240 tatttggagg gcagtgtctg tctaaatgtt actgtaggca ccctttgacc tggcaggttc 57300 cttttttgaa agtttatata tatgtgagac agagtctcat tatgttgccc agggtggttt 57360 caaactcctg ggctcatggg atcctcccac ctgggcctcc caaaatgctg gagttacaga 57420 tgggagccac cacacctggc agagaaagtg atcttatcaa cactcttgct tgagtgtgaa 57480 attcaattgt ttattcaatg ctgcattgtt tgtaagagga acaccaatgc caagtcccca 57540 ggagaccgat ggaagtcaag ttcatcccta caatagaata caaagcagcc gtaacaaaga 57600 gtgaggaaac tgttcatgta tactgcggga tgatctttaa aatctgtggt taagagaaaa 57660 aagcaaagta cggaacatta tgtaacgtat gcttccttcg atttgataac agaagatgta 57720 tatttacttt atttttgtat aaaatatttt ctgaaagaag acataagcaa cccatgatca 57780 ttgcctctag agagaggaac tgaggggagg gccataggga atggaatgag aagacttgtc 57840 ccttgtacct ctttgttcaa aagaaatatc aagaataaaa cacatctatg ttactgataa 57900 agatagtttc caaaggctgt gtgcggtggt tcacacctgt gatcccagca ctttgggtgg 57960 ccaaggcgag tggatcgctt gagctcagga ctttgagacc agcctgagca acatggcaaa 58020 accccatttc tactaaaaat acaaaattag ctgggcatgg tggtgtgtgc ctgtggtcct 58080 agctgctcag gaggctgagg tgggaggatt gctggagcct gagaggttga ggctgcagtg 58140 agctatgatt gcaccactgc attccagcct gggcaacaga gtgagacctt gtctcaaaaa 58200 aaaaaaaaaa agttcagttt ttaatattag ctaagtaaaa aaaagcaagg tatagaatgg 58260 agtatcgtag tgccttttgt ggcaacaaaa taggtcgtat ttggaatata tctggaagaa 58320 tgtaagatgt tagcaatggt agcttgcctg tagggtagca atggggggct gttaatttgg 58380 ggagaaagac atatttttca ctgtatacct ttttgagtaa tttgaaagag ttttagcaca 58440 caaatatatt acctattaaa aataattaca aagagaggga gacatgggtg gatgcatgga 58500 tggatagttg gttgggtaga tggatacata gacaggtgga tggattggtt ggtggatgga 58560 tggatgaact gttgggtggg tagatggatt gatgggtgaa tgaattggta ggtgggtagg 58620 gtggatggat gaattggtgg atgggtaggt ggatggatga atgaactggt gggttgctgg 58680 atgggtggat gaattggtag gtgggtggat ggatggattg atgggtgaat gaattggtag 58740 gtgggtaggg tggatggatg aattggtgga tgggtaggtg gatggatgaa tgaactggtg 58800 ggttgctgga tgggtggatg aattggtagg tgggtggatg gatggatgga tgggtgaatg 58860 aattggtagg tgggtagggt ggatgggtga attagtggat gggtaggtgc atggatgaat 58920 gaattggtgg gttggtggat gggtggatga attggtaggt gggtggatgg atggatggat 58980 gggtgaatga attggtaggt gggtagggtg gatgggtgaa ttggtggatg ggtaggtgga 59040 tgtataaatg aattggtggg tgggtggatg gatggatgaa ctggtgggtg ggtggatgga 59100 tggatggatg ggtgaatgaa ttggtaggtg ggtagggtgg atgggtgaat tggtggatgg 59160 gtaggtggat gtataaatga attggtgggt gggtggatgg atggatgaac tggtgggtgg 59220 gtggatggat ggatgggtga atgaattggt aggtgggtag ggtggatggg tgaattggtg 59280 aatgggtagg tggatggatg aatgaattgg tgggtgggtg gatgggtgga tgaattggta 59340 ggtgggtagc tgaatggatg aattggttgg ggggggtgga tggatgaatt ggtgagtggg 59400 tagttgggtg gatggatgca ttggtgggtg ggtggatgga tgaattggtg gatggatgga 59460 tggatgggtt catggttggg tgataaatat atccatgggt atacatatgg atgtgtacat 59520 agataattct ctggctatga tagggaggac tggctgtggt ggggaacact gactgtggtg 59580 gggagcactg gctgtagcgg ggaggactca gtaggacaag gagaggctgg aggcagtgaa 59640 gacttaggaa gcagttgcat agtcctggca aggaataatt tggggctagg atcaggtcaa 59700 ttaaatgttt aacattggaa ctatgtctct tgtatacata actgcatatg tcaagtcttg 59760 gtatcgtttt ctttctagca gggcacattc ctttggaatg agcttttact ggcaactgct 59820 cagaagctgt tctgtatata atgaccacca acagtttaat ccttttttca gccatcacct 59880 caggaattaa cagtagtatg aaatcaatta aaataatcag tctttgagat gtcatgcctt 59940 ctccacgatc aacttcttct ttacaaggct gtgttccaaa tacgccaggc caaaaagacg 60000 tgaactttgt cctttttagg gtttgtgtct tgatgtttcc tggctaaatc tctttgtatg 60060 tgttggcctt gtaaggttta cttttttttt tttttttttt gagatggaga ctgtgttgcc 60120 caggctggag tgcagtggtg cagtctcagc tcactgcaac ctttgcctcc cgggttcagg 60180 tgattctcct gcctgagcct ccctactagc tgggattaca gacgtgcact accctgcccg 60240 gctaattttt atgtttttag taaaatataa aaattatgtt tttatggggg gttcttgcca 60300 tgttggccgg gcttgtctca gactcctgac tgcctgccta ggcctcccaa agtgctggga 60360 ttacaggcat gagccaccgc gcccaaccta ataactagat ctctttaatt attggaacat 60420 gtatattttg atcagattga cacttttttt tttaagtgaa gtgatcttat ttccctcatt 60480 tctcattttt aacttttttt tttttttgat atggctttaa agctctgtgg agctgtaagg 60540 gtctgggttc cttgacactc catgggggtc tcaggtgatc gtgggagggc tgttggaatc 60600 agagctattt ggagggtgca taggccagta ggatgggaag gctgtgggag aagtgggctt 60660 tttggggacc gcagccaaat ggacaactgg gcctaatcta aagattggcc cctcccagct 60720 cctactgatg gtcatgtaac aggaatgggg cccagcacca ccagattttc tgattttttt 60780 tttttttttt gagacacagt cttgctctgt tgccaggctg gagtgcagtg gcatgatatt 60840 ggctcactgc aacctccgcc tcctgggttc aagtgattcc cctgcctcag cctcccaagt 60900 agctgagact acaggcatgc gccaccatgc ctggctagtt ttttgtactt tagtagagat 60960 gaggttttac catgttggcc aggatggtct tgatctcctg acctcgtgat cctcctgcct 61020 cggcctccca aagtgctggg atgacaggcg tgagccactg cgcccagaag attttctgat 61080 ttttaaagtt atgccagaga ccgggcgtgg tggctcacgc ctgtcattcc aacactttgg 61140 gagactgagg ttggcagatc acctgaggtt taggacttcg agactagact ggccaatatg 61200 gtaaaacctt gtctttacta aaaattcaaa aaaaattagc caagcggggt gaccgcagtc 61260 ccagctattt aggaggttga ggcaggagaa tcacttgaac ccgggaagca gagattgcag 61320 tgagccgaga tcgcttgaac ccgagaagca gagattgcag tgagctgaga tcatgccact 61380 gcattccagt ctgggtgaca aagcaagact ctgtcaagaa aaaaaaaaat aaaaataaaa 61440 agccggaaat caaattttaa atgttgggat ctaatctaat ttttttaaaa acaaaaagta 61500 tgcctaaaac aacagcaata acaacaagcc atctatgggc caaactgtgg gtggggaaac 61560 ctattttgta cttcttattt tatccgattg aattgtggtg gagataggaa attgagaccc 61620 caaaaagggt agtaagtttt cccaaagtta tttagtcagt tgccagatta tggcttgaat 61680 taaatttaaa ttcttcagct gggcatggtg gtgcacacct gtagtatagc tgcttgggag 61740 gcagaggtgg gaggactgct tgagcccaaa agttcaaggc acaggaagct gtgatcttac 61800 caccacactt cagcctgggc aacagagcaa gacctcattt caaaaaaaga aaaaaaaaag 61860 aaaaatttaa attcttcatt acagaacagc tgatggtgga ggtttattct tgggcaggta 61920 catctgatct atttatgtat gtatctatga atttgtctat ttggcatggc tctttagcaa 61980 aatacaggct tttttttttt aagtaaaagt aattgaaaca aaatttgttt ccaaggctgg 62040 acagctcagt ggcaaaatgc agacttgaac aacattgccc gagtttgaat tcagctccag 62100 agcttaccag ctgtgtgata ctggacacag tatttaaccc ttctgtgcct gagtttcaca 62160 tctgaaaaag gagatgataa aaataattac agaatgaaag gagataatac acatgaggta 62220 cttagaataa agcctggcat acagaactgc agtttggttg ttatccgtgg tggtggcggt 62280 ggcggtggcg gtggcggtgg cggtgatggt ggtggtgatg gtggcgatgg tgatgatgat 62340 ggtggtgatg gtggtgatgg tgttggcagt gatattggtg gtggtgatgg tcatagtggg 62400 gaaggtgatg atgatgaatg aagatgatta gaaagtcctc agttcacaag gtcagagtga 62460 tctagatgac acagggctct tcggttataa gagaatatcc ttcagggttc ctttaaatgg 62520 ctctctccat ctttcgtact acagtgggac ttgccacagg ttctggggac tgttaatgtg 62580 agatgagatg ctacatacct ttttgttgtt ggtgggtttt tttgtgtgta tgcactgttg 62640 tgtgtgtgtg tgtgtgtgtg tgtgtgtgag agacagggtc tcgctctgtt gcccagggtg 62700 tagtacagtg gcatgatctc agctcgttgc aacttccgcc ttccaggctc aggcactcct 62760 cccacttcag ccgcctgagt ggctgggaat acaggcacgc tccatgctca gccacttttt 62820 gtgtttttca tagaggcagc atctcactat cttgcctagg ctggtctcga actcccagcc 62880 taaagtggtc tgcccacttg gcctcccaaa gtgctgggat tacaggcatg agccactgca 62940 cctgacctgt atgctcctgt taagagagct ttatttttat ttatttattt tgagacaggg 63000 tctctgttgc tcaggtggga gtgcagaaga caccacatac ctttatccct tgttcctcat 63060 ttcttagtct ttctggctac tgatcttttt agtttgcgtg ttcatcctga aaggtccttg 63120 gatatatagg agccttgtct gtttcttcaa accccgtggc agctggtttc atgctccagg 63180 cgagctcctg tcctctgggg tgtgtcctgc tgacccctcg cctgtgtttg tgttcgcagg 63240 actggaatgt cacgtggaat accagcaacc ccgacttcac caagtgcttt cagaacacgg 63300 tcctcgtgtg ggtgccttgt ttttacctct gggcctgttt ccccttctac ttcctctatc 63360 tctcccgaca tgaccgaggc tacattcaga tgacacctct caacaaaacc aaaactgtaa 63420 gtcactgggg ggtttcgttg tggggggtgg gaaggtgcac ctggacgggg agtggtggtt 63480 ggtgataact gacatttctc ttctacttag ttgaccctaa gttccttctt ctagaaggca 63540 gaagaataat gtgggaggtg aaaactggag ctctggagac aaacatgggt acaaatcttt 63600 gctctgccgc ttagtatttg gcctcgagca aattttttaa cctccccaag cctcagtttc 63660 cctgtttatg caataggaat gataggcttg ttctcaaggc attcctggga gattatcagc 63720 tcttcccctc ttactgagcc gatctccttt ttatttaatt aaatatattt atatagattt 63780 tttctggcca atttttaatt tattttttgt agagaggggg gacttgctgt gttgcccggg 63840 ctggtcttga acacctggcc tcaagcagtc ctcctgcctt ggtctcccaa agtactggga 63900 tgctcagtgt gaaccaccac gcctggcccc taattttttt tttaagttgg cttttatttt 63960 gaaataattt aaagctacag gaaaattgca ataatgggcc aggcgtggtg gctcacgcct 64020 gtaatcccag cactttggga ggccaaggcg ggcaggtcag gagtttgaga ccagcctgac 64080 caacatggtg aacctgtctc tactaaaaat acaaaaatga gctgggtgtg gtggcatgtg 64140 cctgtaatct tagcaacttg ggaggctgag gtgggaggat cccttgaacc caggaggcag 64200 aggttgcagt gaactgagat agtgccactg cactctagcc tgtgcaacag agcgagactc 64260 cttctcaaaa aaaaaaaaaa aaaaaaaaag ttgcgatgat accaggaact gctgcctgat 64320 tttctctatc catcactcat agtcactgtt tcctgttttt tttttttttg ttgttgtttt 64380 ttgttttttt ttgacacaag gtgttgctct tttgcccagg ctggagtgca atggtatgat 64440 cacagcatac tgcaaccttg aactcctggc tcaagccatc ctcctgcctc agctttttga 64500 gtagctggta gctgggactg caggcataca ccaccatgcc tggctaattt aaaacaattt 64560 tttgtagaga cagggtctcg ccttgttgcc caggctgttg tcaaactcct ggcttccagt 64620 gatcctcctg cctcggcctc ccaaagtgct ggtattacag gcatgaatct ggcctgtatt 64680 cactgatttt ttaatctttt gctacatttg ttttatcatg agcttttgtt ctctctctct 64740 gtatgcatgc tataatttat tttttctgaa tcatttgaga atggatgcac cttgaaacat 64800 atcccacccg tagagggctc tcagtaaata ctggttgaat gaatggttgt cgtggagggc 64860 tttcttgtgc agtgcgccgg agttgcagct agagatgagc tgtgagctga gctcttgagt 64920 gttcaggcac cggggagcat ggtgaccaga caaacagtcc tgttggaggt agtggggcgt 64980 agcaggctga ttacagacca tcacgtgccg gcctggatgc cagctcacca taccgaggac 65040 ttgtccttat tccagtggat atgtgccatg tcctaggact gtggctgatc atttgaaggc 65100 tggctggttc tcctatccct ggggctgagc tgttcgtgca ggccctgggg gaggttccag 65160 ggcggtctgt tgtaggatat gtatgtgctt ctcttccagg ccttgggatt tttgctgtgg 65220 atcgtctgct gggcagacct cttctactct ttctgggaaa gaagtcgggg catattcctg 65280 gccccagtgt ttctggtcag cccaactctc ttgggcatca ccatggtaag taggagctgg 65340 ctgtgacccc tgggccatct gctgggctca gtggagacca aaagtaataa ctcgtaagac 65400 tagaatcata gttttttaag gcaatgatca gctggagctg ggatataaat taaatgtagc 65460 cttttttttt tttttttttt ttttaaagac atgagatctc gctttcatcc aggctggagt 65520 gctatggtac catcatagtt cactgcagcc tcaaacttct ggcctcaagc aatcctccta 65580 cctcagactt ctgagtagtt gggactacag gtgtgtgtca ccacgcccag cttatttttg 65640 gctaatttta aatttttctg tagaaatggg atctcactgt gttgtctagg ctggtcttag 65700 actcctggcc tcaagtgatc cttccagagc actggcatta taagcatgag ccactgttcc 65760 cagccccagc tgcagtcttt ggatggggca tgtgttgtcc agtttgccac agtccccacc 65820 atgccctatt gtcttccctg ccactgattg agtggcagat gccccctttt gttgcgtttg 65880 ccacactttg ctcttgcatt ggctactttg gtcacttata tactaactgc ctggggtcta 65940 atggccttga gttttcacta tctggcatag ggggtgggtt gctaagctaa ataggaaact 66000 gctctgtccc gggggataca caacttagtg agtgacagag acaaggaaac aactttatta 66060 attacagctg gtgtgtattg agcacttact atgtatgtac ctggcagtat tcttggtgtt 66120 tcacgtgtct tgaaattcat tgaattttca caacaaccct gtgagatggg tcctgctttg 66180 ttcccatctt acaggtgagg aaaccaggca agagaggtta agtgtcctgc tcaagatcac 66240 accactaatg tgcagccgag tcaggggtgg gaccccagat gccatgcttt tagcccctgc 66300 aacctgcagc ttctgagccc tgaacagaga gttctcggag agtgtagccc ttgagtattg 66360 taaaaagagg agggaggctg ggcatcgtgg ctcatgcctg taatcccagc actttgggag 66420 gctgaggcgg gagaatcact tgaggtcggg aatttgagac cagtatagcc aacatggcaa 66480 aaccccgtct ctactaaaaa taaaaaaatt agccggcgtg gtggcacacg cctgtagtcc 66540 tagctactca agaggctgag gcaggagaat tgcttgaacc cgggaagtgg aggctgcagt 66600 aagccgagat cgcaccactg tgctccagtc tgggggacag agcgagacct catctcaaaa 66660 aagaaaaaga aaaaaaaaag gagagaacaa gtttaaggca ggacattctg agcagggtga 66720 acagtgtgtc cagggagggg tggaaggtta aggggaggat gcaggcaggg aggacaaggt 66780 gttcggtgaa ggaacacggt gtgaaggttg gggggataga gtggatgtga cagaggggtc 66840 aggaaagaca acgtggagcc aggttgccaa ggaccatgaa tctttatttt tctaaattaa 66900 tttttcattt tttaaatttt agagtcagag tcatactctg ttgcccaggc tggacttcac 66960 tggcgtgaga tcacagctca ctgcaggctt gaactcctgg gctcaaatga tccttctgcc 67020 tcagcctccc aagtagctgg gagtgtaggc atgcaccaac atgcccatct acatttattt 67080 tttatttatt tattttttta tttttccccc cgagatggag tttcgctttg ttgcccaggc 67140 tgaaatgtaa tggtgtgatc ttgagttgcc gcaacctctg cctcctggat tcaagcgatt 67200 ctcctgcctc agcctcccga gaggctggga ttacaggcat gcgccaccac gcccggctga 67260 ttttgtattt ttagtagaga tgggatttca ccatgttggc caggctggtc tcgaactccg 67320 gacctcaggt gatccaccca cctaggcccc ccaaagtgct gggattacag gcatgagcca 67380 ccacccccgg ccagtttgtt atttttgtag agacagggtc tccctatgtt gcccaggctg 67440 gcctcaaact ccttgtctca agtgatcctc ctgtctgggc ctcctaaagt gctaggatta 67500 taggtgtgag ccaccatgcc ctgcccagac catgattcta tatagcacac atatgtgctg 67560 tccactctct gccaagaact gtcctaatcc ctttattaac ccttttacgt tgtaaataag 67620 gtaagcaaag tgtggtacag agaggagaag gactggccca aggtcacctg gtcagtaagt 67680 ggtagagcca gcttccagtc taggccccag cgtgtagcct ggcacctgct ttacgcctgg 67740 ctctcctgct gggtttgatt cccctttgtg tcctcagagc ctggccctgt gcctggcatg 67800 cagtaagcgt tccataaatg catggaggga atgagagagt aaagggcttt gctttgtcct 67860 gaattcgggt cttgggctct gtgttctggc agtggggtat tagagtggat tttttttttt 67920 ttttttcaat ttcactataa tagagacagg gtctttccat gttgcccagg ctagtcttaa 67980 actcccgagc ccaagtgatc cctctgcctt ggcctcctaa agtggtggga ttacaggcat 68040 gagccaccat acgtggtcag ctgtttttga cttgagtagg tcatcctccc ttaacattcc 68100 ttgttcctgg tctttttttt ttttcctttg aggcagagtt tcgctctttt ttcccaggcg 68160 caatggcatg atcttggctc actgcaacct ctgcctcccg ggttcaagtg attctcctgc 68220 ctcagcttcc ccaataactg ggattacagg cacgcgccac cacacctggc taatttttgt 68280 atttttagta gagatggggt ttcaccatgt tggccaggct ggtctcaaac tcctggcctc 68340 aggtgatcca cgtgccttgg cctcccaaag tgctggtatt acaggcgtga gcaactgtgc 68400 ctggccgttc ctggtctttt gatcgttcat ttatgcctct gtcaccctgg gggaaacagg 68460 ggtgatagtc tgagggttgg ggcttttgac tcctcagggg actctgagct gggctggcca 68520 agaggtgaac tggcctgtga gatcctcagc ctctctttat ctacctgaga tctctgggat 68580 ggaatggagg accaccagct cagctgtgaa tgtgtcagaa acattctgac tatatcccag 68640 ggaaccagga tatgcaggca ctggtaatat gggacaggat gcagccagca catgtttttt 68700 ttttttttct ttgagatagc gtctcactct gtcgcccagg ctggaatgca gtggcatgat 68760 ctcagctcag tgtagcctcc gcctcccagg ttcaagtgat tctcctgcct cagcttccca 68820 gctagctgtg actaaaggcg tatgccacca cgcctggcta atttttgtat ttttagtaga 68880 gatagggttt caccatgttg gccaggctgg tctcaaactc ctgacctgcc cgccttggcc 68940 tcccaaagtg ctgggattac aggcatgagc cactgcacct ggctgatttt ttttttttta 69000 tccctactct gtatcaagcg ttggagacac aaccatatag tctagctgtg caaacagaca 69060 ttaaacaaat gattcctcaa aaggcacaaa gtgtttgaac gtctgcagag tgctgtgtga 69120 gggtgaaggc aggggagctt ggtttggtct ggggcatagc caggcttctc tgagggaggg 69180 atggtggagg tgaagcctga gaatgagcaa gttgttaaaa agcttaaggg gctgagggca 69240 gaggaccagc tgcggagaaa agcacatgta aagtcctgag ggtcacaggg aaaacttgag 69300 agttgtgtgt ggctggagca gagatggccg aggcagagag caggggcgat ggggcagagg 69360 ctgaccccgg gaacgttgag catcagggca agtgggtttt gttttctgta ctgggttctc 69420 tgcctgttct tttaaataaa gttttattgg catgaaggca tgtccattca ttaacatctt 69480 gtctatggcc actttcacac tgcagtggca aagctgagta gttttgatgt agtctatggc 69540 ccatgaagtc caaaatattt attacgtggt ccattaagaa atagtgtggc tgggagcagt 69600 ggctcacacc tgtaatccca gcaccttggg aggccaaggc aagtggatca cctgaggtca 69660 ggagtttgag accagcctgg ccaacgtggt gaaaccccgt ctttactaaa aatacaaaaa 69720 ttagctaggc atggtggcgg gcacctgtag tcccagctac ttgggaagct gaggcaggag 69780 aatcacttga acctgggagg cggaggttgc aagtgagctg agattgcacc actgcgctcc 69840 agcctgggtg acaagagtga aactctgtct caaaaaaaaa cccaacaact cctgtcttgt 69900 gcttctctcc tcagctgctt gctacctttt taattcagct ggagaggagg aagggagttc 69960 agtcttcagg gatcatgctc actttctggc tggtagccct agtgtgtgcc ctagccatcc 70020 tgagatccaa aattatgaca gccttaaaag aggtaagtgg cagtctcctt cctcatcttc 70080 cttcagtgga cccggaggga gagatgctgg gtccctctgg cttgtgtaga agtcatgcgt 70140 tgccatggga accaggggct gggtaccaca tgcacctagc ttctcccttg gtgactttcc 70200 taccccacca aatcctcact aaatcagccc cagccttttt tctagcacct cctttcccca 70260 gggcctgatt tgtctgtgtt gctccaaggg gctcccatgg gacctccaag ggcaggagct 70320 gtgggccgat gccaggctgg ccccatcagc aggaaacagc aagacaggcg gctccaaatt 70380 ttgccaggct gggatggagc cgagccggga acggtgtttg cagagtgact gttcccctgg 70440 gggaccctag gcttgtcctc gcgttacctt tgtcccatca gttgctgctc tggctgggga 70500 agttgtttac attggctgct gtgtgctgct gctaggaatt ttgaggagtg tgcacttttt 70560 tttttttttt tttgctgttg ttgaggcgga gtctcgctct gtcaccaggc tggagtgcag 70620 tggcacgatc taggctcact gtaacttcta cctcctatgt tcaagcgatt ctcctgcctc 70680 agcctcccca gtagctggga ccacaggcac gcgccaccat gcccagctaa tttttgtatt 70740 tttagtagag acggggtttc accacgttgg ccaggatggt gtcgatcact tgacttcgtg 70800 atccacccgc ctcggcctcc caaagtgttg ggattacagg cgtgagccac cacgcctgac 70860 ctggagtgtg tgcttttgga ataacctgct gttcctgcca tcttggagct aattagagac 70920 tggcatgagg caaaggaagg aaaagaagct gaacatttga ctattgattg cctacatatt 70980 attatgagtg atagcagctg atgctgattg agttcatgtt ttcaaagtgc ctcgcagggg 71040 actgtgtatg tgtcacgaat aatcttcctg acctcttgca gtgacttgga cagaatttct 71100 cagcctcagc actaatcgac attttggatt ggagactcgt tggttgtagg ggctgtcctg 71160 tgctttgtag acatttaggg gtgtccctgg cttcccctga ctgggtgcca taacactccc 71220 aagttaccac aaagaagata tccccagaca ctgccagatg tttcctggga ggcagaatca 71280 cccctggtta agaaccaccg gtggtttata ggtggggaat ctgaggcaca gaaaggttaa 71340 ataagttgac aagatcccac agccagtgtg agagagccag gccttgatac agctctgttt 71400 cactcccaag ccctgtcttc ctcccatcag gcagcggtga gcagtgagac tacccgtgat 71460 ggagccggct ttctgccatt acatcccggg gggagctggg agcccctggg gagcctgcag 71520 tgtccctgtg gctgagtggg tttctgccac ctgctctcag aatgtgatct tggttttttt 71580 tttttttttt tttttgagat ggagttttgc tctgtcacac aggctggaat gcagtggcgt 71640 gatctcggct cactgcagcc tccgcctcct gggttcaagt gattctcctg tctcagcctc 71700 ccgagtagct gggattacag ttgcccacca ccacgtctgg ccaatttttg tatttttagt 71760 agagacgggg tttcaccatg ttgaccagga tggtctccaa ctcttgacct caggtgttct 71820 gcctgtctcg gcctccaaaa gtgctaggat tacaggcgtg agccaccaca cccagcccca 71880 gaatgtgatc tttttcttcc ttccttcccc accatgtagg atgcccaggt ggacctgttt 71940 cgtgacatca ctttctacgt ctacttttcc ctcttactca ttcagctcgt cttgtcctgt 72000 ttctcagatc gctcacccct gttctcggaa accatccacg accctgtaag tgtgaccaca 72060 gatgagtgtg tgtgcgtgtg tgtgtgagag agatgcgtga cacagtacca gctaacattt 72120 cttagatcca tccaggatct cgttccagcc tccctcaacc cctgatacag ggaatatcat 72180 cccacctact ttacagatgg aaaaactgag gcttagatgt ggctggggga gctgaaggag 72240 agaatctgct ttgtcattga tgaactgctg tcttgcaggc ctgtaggttt ctcacttggc 72300 atggtgattt tggaaaatgt gagcagataa ttacaaatca ggtatttttt atgaattcta 72360 gctgtccaga tgttctggaa aagtaaagtt ctgacagatt aggcctataa tcctacaggg 72420 cagagctgag gagttgctgg agtccccggc actccctgtt gtattatact ggcatgcttt 72480 cctcacttgt ggcaaatgcc tggcccctga gggatttgag tgtgagatcc ttggtctatt 72540 ttgtcagttt cagagaaatt ctgtaaatat ggaaacttat cagtgaggag tgtagagatg 72600 gccaccgttt ctgctagtag aacaaaaggg aacactttat taatttccct taattctttt 72660 cttctttttt ttgagacagg gttttgctct gttgcctagg ctggagtgca gtggtgtgat 72720 ctcggctcac tgtagtcttg acctcctggg ctcaagcaat cttcctacct cagctttctg 72780 agtagctgga attacaggca cacaccacca tgcctggcta attttttttc tttcttcaac 72840 ttttatttta agttccaggg tataggtaca ggatgtgcaa gttcgttaca taggtagatg 72900 tgtgccatgg tgatttgctg cacagatcaa cccatcatct aggaatcaag cccaggatcc 72960 attagctatt cctcctgatg ttctccctac acctgctccc caacttggct tacttttaat 73020 taattaataa ttaaagatgg ggagatggtc tcaaacccct gggctcaagc gatcctcttg 73080 ccttggcctc tcaaagtgct gggattacag gtgtgagtca ccacgcctcg cctattcttt 73140 atttttttaa atagagatgg gatcttgctg tgttgcccag gctcatgtgc agcttttgat 73200 aagagagatc tgggaaggcc tgcccagaaa actgcatgtg agcggagacc tagaggggtg 73260 aggtagtggg tggagcaaac acctagagga agagtgttcc aggcagaggg gaataagtac 73320 aagggccctg gggtggggag gtgtggagag aacagcaaga aaagccagca cagcaggaga 73380 aggctaagag acagtgggtg cctgagaggt gggacagccc ccttgtgagc cagatgagct 73440 gtttgggttt tattgtgagt atggggcagg gaggccttgg agcacctatt tgatgctgat 73500 tcatggctag tcagctggta atgggcggat tgcagtggga gaacttttca cctctgtggt 73560 tctgttgggt ttggcctaaa cctctgtgag gggcagaggc tcaccttgtg ggtgacgaaa 73620 gggcttggtg ggcatcagta tggaggagga ggttgatgat aactaagaga ttttagaaac 73680 ctatgtctca ggccaggtgt ggtggctcac acctgtaatc gcagcacttt gggaagctga 73740 ggcaggcaga tcagttgagt tcaggagttc gagaccagcc cagccaacat ggtgaaatgc 73800 catctctgct aaaaatacaa aaattagcca ggcatggtgg tgcatgcttg taatcccagc 73860 tagtcgggag gctgaggcag gagaatctct tgaccctggg aggcggaggt tgcagtgagc 73920 agagatcaca ccactgcgct ccaacctggg tgacagaatg agactctgtc tcaaaaaaag 73980 aaaaaagaaa tgcatgtccc agtgtatgtt ctgaggagtc ccgtgttggt atttccttgc 74040 ccaaagagga gctgggttgg agaaatgagc aagtgcacac atctgtgtat gtattcctgt 74100 gcatctgtgt gtacgtgtgc atgtgcctgc ttgtgtgtct cggtagtcat aggcatgtat 74160 atgcgtgtat gtgcttatat gtgaatgtgt gcttgtgagt gtgtttatgt tcatgtatgt 74220 gtgtgtttgt gtgtgtgtgt gtctttgtgt tgtgtgtgct tgcatatgta taaagttcac 74280 aaaggcaatg gtgactcatg cctgtaatcc cagcactttg aaaggccaag gctagaggat 74340 cgcttgagcc caggggtcac cccattttgg atccctggct ggtgcctgac acagaagaga 74400 ggggctcatg agtcagtggc tgttatatgt attgtgtatc agtgtgtgta agtgtgtggc 74460 agccgagtgt ccctgtttgt caaatgttgg gctattcttt tttgtctttt gtttgttgtt 74520 tttttctgtt gttttgtttt gtttttagac ggattcttgc tcttgttgcc caggctagag 74580 tgcagtggca tgatctcggc ccactgcaac cccgcctcct gggttcaagc gattcttctg 74640 cttcagcctc ctgagtagct gggattacag gcgcccatca ccatgctcga ctaatttttg 74700 catttttagt agagatgggg cttcaccatc ttggcccggc tggtctcgaa ctcctgacct 74760 caagtgatcc acccgcctcg gcctcccaaa atgttgggat tacaggtgtg agccaccgtg 74820 tctggccgag ccattcttta gaactgggat ttatacaaaa caagtcacac ctcaactggg 74880 tggctgcaga ccttggattg ctcagggtaa acagagtctg gttggggctg cctggctggc 74940 gtggggatca cccaacccat caagcttcct ctgggagcct gggaagagct ctcttgccat 75000 ggatggttct ggaagctttt tgaaggaggg actttcttaa tttctgatct cccttgggaa 75060 tctggataaa ttccctttca cttctcccct gggcgtgtgt gtaccagggt gactcacaga 75120 tctgacttgg accttttttt gtgctttctg cattcctggc agcctgggcc tgggatttgc 75180 tctgccaccc tgggtgacat gaagctctca gctctggcgg ctaaaaggct acactgttgt 75240 ggggctggga caccctgact cttctcccca gtcattgttt tctgtttctg tgtcatctcc 75300 cccagctcgg ctcctcctgt gtcactgctg gtcttccaag atggtggaag acactgtggt 75360 ttgtctcttt gcagtctcgc tctgtcgcca aggctgtagt gcagtggcat gatcttggct 75420 ctgcagcctc tgcctcccag gttcaagcaa ttctcctgcc tcagcctcct gagtaactgg 75480 gactacaggc gcacaccacc atgcctggct agtttttgta tttttagtag agatggggtt 75540 tcaccgtgtt ggccaggatg gtctcgatct cctgacttca agtgatccgc ccactttggc 75600 ctcccaaagt gctgggatta caggcttgag ccaccgtgcc cggctgtggt ctgcctcttg 75660 tgcagtgaga tccagcaggg tgtcaaatgt gggtgtgcag gctgctgcat ttctgacatt 75720 tgtgcacctg tccaggagag aacactttga ttggctgaca ctctctgtcc aggaagcctg 75780 aacttccctc tgggttcctg ttcaggaacc ccatggggtt gccatttacc tttttgcaga 75840 ttagagttta gaccaggagt tagccagtag cccatgggcc gaatctggcc tgctgcctgt 75900 ttttgtaaat aaagttttat tggaacacag ccactcgcgt tcatcacata gtgtctacag 75960 gtgtctggag ctgcagcagt ggagttgtgt agttgctaca gagactgtag cacccacaaa 76020 gtctaagata cctaccatct gaccctttac agaagaagtt tgtccacccc tggtctaagc 76080 atttctttag ctctgatgac tttttagctt ccttttttgt cccctttcca tttgcaggca 76140 ttctttcttc ctatgcaagg caaggacggg aatcgacatt tattagatgc ttgcggtgta 76200 ctggctagca ctatgctaag ttctttatat gcatgtctca cttgactctc acagcagtcc 76260 tggtgaactt ggtactattt ttctcatttt acagacaaac aatcgcagac ataagtgcct 76320 tgctcgacct gagtagtaga gcagagattc gaactcacga ctggctgttg tgcacaatca 76380 tgtcacttcg cttggttgta actgctgaat gggagggtct tggctaaata atggctttgt 76440 gttaggctag aggcttcacg tggcagtatc caccttgtaa cctcagtgcc taagacacag 76500 ccaggcacac ggtgggcctg tagtggtaat ttattgttgt gttatatggg gaggtgctca 76560 gtacatgtgg cacgtatatt atgtcttgca taagggtgaa gtgtgcatga ggcctcacag 76620 gacatcagat taagctgctt ctctgccttc atcctgttca agtattacca gcaagaaaga 76680 ggaaggggac tgatgtatgc acagatgttc tgaaggcttg gcatggtgtc aagagcctta 76740 tttttttttt taatgttgca ttttgggggg ttaaatatat gtaacctaag atttgccatt 76800 ttaaccattt taagtatgca attcagtgat gctaagtgct tttaaaaatc ttgttcaagg 76860 ccaggtgtgg tggcttacac ctataaaccc agcactttgg gaggccgagg caggtagatc 76920 acctgagatc aggagtttga gaccagcctg accaacatgg tgaaatccca tctctactaa 76980 aaatacaaaa attagctggg catggtgttg agcacctgtg atccctgcta tttaggaggc 77040 agaggcagga gaattgcttg tgcccgggag gcggaggttg cagtgagctg agatcgctcc 77100 agtctgggca acagactgag accctgtctc aaacaaacaa cgaacaaatg aacaaacaaa 77160 caaacaaaat aaccacataa ctacctagca acgtagccta gcaattgaga tgggggcaag 77220 gaagggtagg aaccaggtcc tgtgagaatc agctagactt gtggctttgg gctcggtgct 77280 cttcctttgg ggacgtcagc agccccttct tgaaaacggg ttgcaactcg atttgttgtt 77340 ggcttcacct cctctctctg tcccagacct gagccctgtg atctggggag gaggacaacg 77400 ggacaacctg tttgcttgtt ttcccatcac tctcagggat tgaatcacag tggagccagg 77460 aagatgggga gagtccaggc ttgctgctct cccatcctca gagcagcagc aggccatcca 77520 tcacctgtcg cctgtcctca gagtgatcag ccaaggcctg gggcggctgg ggtcaggtca 77580 ggcagggcgt gggtgggagc tggcagggct ggctcctcca ggccacttcg tgctgagtca 77640 ctgagtcggc caatcctccc cagctggccc tgctcccact ccatgactca gatgtctatt 77700 ccagccctgg ctgcttggtg gggctcctcc catctgtcct tctggctctg gggctgccga 77760 ggcttttggg agcctgggca gggctgacca agactgccag agctccggcc ggtccccagt 77820 ctcctgcctt ttttctcatt ggcactgagt ctgtggttta ggtttggggg aggagggtct 77880 tgtagataag gggatcaagg ccaaaggaga tcatttatta ggtcccagct gaaagcagag 77940 gtccttggac cagttggaat gctcgacatc ccccggaagc ttgctagaaa tgctgggtct 78000 caggcctcat cccagaccta ccaagtcaaa ctcattttaa caagatctcc aggtggttca 78060 gggttgcaaa tcactggttt ggaacattca gtgaaagcta ctcagctcgt ttgcagtaag 78120 aggtattttt agtcctgtct gtataatatg taatattttc cccccagcat tttactatga 78180 acattcttaa acctacagaa aagtcgaaag aattctactg tgagcagtca tatagttggt 78240 acctagagcc acagttaaca ttttgctaaa cttgctttgt cacatatctg tctgtctaac 78300 cagatagcta atcagccagc caaccggcta cttttgtttt gttttttgtt tttgagatag 78360 ggtctcactc tgtctcgcag actagagtgc agtggtgtga tcatagctca ctgcagcctc 78420 caactcctgg gctccaatga tcttcccgct tctgcctccc aggtagcttg ggccctacag 78480 gtgcacacta ctgtgtttgg ctaattttta aattttttgt aggcgtgagg gctccttatg 78540 ttgcccagtc tggtcttgaa ctcctggcct caagccatcc tcccacctca gcctcccaaa 78600 atactgggat tacaggcctg agccactgaa cctagttttt ttgatatctg aaacttcctt 78660 cgaaatatat tagtattctt tcatgcaccc acttccaagt aaatcattag ctagagttta 78720 agatctgttt acacttctga gttttttgct taaaatttac atacagtgaa attgctgatc 78780 tcaagttagc atttgatgaa tcttggtaaa ggaatacttt aaacccctgt caagatatag 78840 aacactgcaa ggacgccagg aagttccctc gtgccccttc atgatcagtc tctgtcccca 78900 cccaccaagg cctgatcttg gaccgttgat taaagcgttg aaactccatt ttctttccat 78960 ttctccgtca tgctttcagt catttaataa tcaggtgttg tgccaggggc tgagctagaa 79020 agaaacagac cttgaccact gccctggagg agagatggaa ggtgggtggc aggcagttga 79080 accaacaact gcaggatgga cagtgggggc tctgagggag ggaagtgctg ggagttgtgg 79140 gggctgggag agtggtccct gactcagcct ggggctccag ggctagcatc cagggaggag 79200 aggggatgct caagtctaag gaatgcgagg ctctggccag gtgaatatgt ttggaggtgg 79260 tggggtggga gggtgctcct ggtagagcaa ctggcatgtg caaaggtcca gttgagggag 79320 cttgtgggtg ttgggaatca cttggaattc ggcttggcta ggctgggtgc agtggctcat 79380 gcctgtaatc ccagcacttt gggaggccga ggcaggcaga tcacctgaga ctaggagctc 79440 aagaccagcc tggccaacgt ggtaaaaccc cgtctctact gatcataaaa aaattagctg 79500 ggtgtggtgg tgcatgcctg taatcccagc tactcgggag gctcaggcag gagaattgct 79560 tgaacccggg aggcggaggt tgcagtgcgc cgagatcgcg ccactgtact ccagtctggg 79620 cgacagagca agactctgtc tcaaaagaaa gaaagaaaaa aagaattctg cttggctaga 79680 ttggaagggc taggatgtaa gcgaaaagag aggcaagagt cagcatcaga gatcaagggt 79740 gcaattatgt gtcacaataa ggacttggaa ttttttgttt gtttgtttgt tttgagatgg 79800 agtttcactc tgtcaccaag gttggagtgc ggtggtgcca tctcagctca ccgtgccctc 79860 cacctccggg gctcaagcga tcctcccacc tcagcctcgc aagtagctgg gaccatagtt 79920 gcgtgccacc acgcccaagt aactttttct gtttttggta gagatggggt ttctgtatgt 79980 tactcaggct ggtcttgaac tcctgagctc aagtgatgcc ctgccttggc ctcccaaaat 80040 gctaggatta cagggatggg tgaaccacca catccagcca ggacttggaa ttttaaccct 80100 actgtggtgg gagctgagga aaggtttttc accagtggaa tgacacactc aggttggaca 80160 ggttgtggaa gatcctcagg ctcaaaggaa gaggatacat tggacatggg ggtgaggtcg 80220 gtggcactta aaaagccttt gcaggcaccc aggcaggtag agagggaggc tgagccagga 80280 tattcccctg tgcccactac agcatcaaaa accagaaaaa gggccaggtg cgtggctcac 80340 acctgtagtc ttggcatttt gggaggctta ggggggaaga tttcttgaga ccaatctggt 80400 caacatagtg agaccccatc tcttgaaaca aaaaaacaaa gaaaacagac aagttgatgg 80460 gcaaagggca tgggcaaaga ttctggggtg tgctccagta gaggaaacgg aggtcctggg 80520 cagggaggca ttttgcacag ttggtaagca acagggcaaa caaatcacca gtgtttacgt 80580 tatactggca aatctcttac tgctggacat ttaggctccg tctaataata aggataacag 80640 ctgggtgcac tgtattattt atttagtcct cacagtaggg caggatgatc agtctcccca 80700 cttgacagat gaagacactg agggtcagag tggtgatgtg tcaggaaccc tcccactggg 80760 ttctcacgct tgaaacacag attgctggtc cccacccaca cagtttctga tgcagtaggt 80820 ctgggtgggg cccgagcatc tgcggttccc aacaagttcc caggtgccac cgatgctggt 80880 gacagagctg cgtttgagga tcactgctct aaacattatt gctgctgcac gcattgcctc 80940 ctgctgggtg caggggttgt ggggggcact ttggcagtgc agagcggagg taaccagcag 81000 aaaacccgtt agaactaaaa gctgagagtg tttctgacaa acaggtcaac atgctgaaag 81060 acccagacaa ggtccttaaa ctaccctgcg ctccaagaat cagtgcctgg ggctgccgta 81120 cctaattggt tcaaaccaca gggtttctgg ccagctcatc tggtaccaaa cgtagatgtc 81180 aatatggtgg atgccaaaga acacatcact ctgtttggat gaatcaggct tttcctccct 81240 ctgccttcag ccaggacttc tctgaattgt tttcatttca aatgaaagag ggaccagttc 81300 acaagctgct ttcatgctat ctgggacagg agttactgta tttcagtgtc tgaggctggg 81360 aaaccccctg gaggtggctc tgtcttttgt acctagtgtg tgatgtcaaa agattctcct 81420 tggtttgggt taaatgacat gctccctgga ttacaatcca gtgccccatg attttttttc 81480 ctcctttttt attgtcaatc cttgacctac ttcagaagtt agttgtcttt gttgtcaagt 81540 aaggccttcc acgtcagata gaggctgttt ccaggccggg tgcagtggct catgcctgta 81600 atcccagcac tttgggaggc cgaggtgggt ggatcgcttg aggtcaggag tttgagacca 81660 gcctggccaa catgataaaa cccccgtctg tactacaaat gcaaaaatta gccaggcatg 81720 gtggtgtgca ccatgtaatc cccgctatgt ggcaggatga ggcaggagaa ctgtttcaat 81780 ttgggaagcg gaggctgcag tgagctgaga acgcaccatt gcgctgcagc ctgggcgatg 81840 agagtgaaac cgtctcaaaa aaaaaaaaaa aaaaaaaaag gctatttcct tttttttttt 81900 tttttttttt ttgccagtga aggggggacc ctgtgttggc ctccctatcg gtcacttgag 81960 ataatctgaa aatctgtgtt tagatccata gaagagaggc ggcctgagga gaagaatttg 82020 acaaagctct ttgagtgtgc aaattagaaa tggcaattgc tgggcgcggt gggtcatgcc 82080 tgtaatccca gcgctttgtg aggccgagat aggcggatca gttgaggtca ggagttcgag 82140 accagcctag ccaacatggt gaaaccccat ctctatcaaa aaatccaaaa attagccagg 82200 tgtggtggca gatgcctata atcccagcta ctcaggaggc tgaggcagga gaattgcttg 82260 aacctgggag gtggaggttg cagtgagccg agatcgggcc actgcactcc agcctgggcg 82320 acagagtgag actcagtctc aaaacacaaa aaacaaaaaa ctgtgcagtg ttctgtctgt 82380 caatgtcctt gttgcatttg cagggcaggt tttctaccag tggctgggga cttagtttta 82440 ctgggccgag ggaaggttag gatttgaggg tcttgttaag ctggatatgg gctgcatttc 82500 aagcctcccc tggctgtctc tatcctgcgt gttgatgcca aggctgaaga agactggatt 82560 tgcaggcaaa agactgtcat ttgaggcctg ttttcacccc ttaatcactg tgtcttggta 82620 tgttgtgggg gttgaggtag gcagaggtta gccaaccttt tctggaaagg gctggctgat 82680 aaatacttga ggctttgcat cccatacact gtctgtggca acccctaact ccgctgtgta 82740 gctcaaaagc tgccatactc atttataata cataaatgaa tgggtgtgac tgttccaatg 82800 aaactttatt tataaatagc tggtctgtgg gccatagatg cttctgatat ataaagcatc 82860 tggtatagtg gtgtattgtg aacccactgg ggttttttcc cccccaaaca cttgagcttt 82920 attgatgtat attgacaaat aaaaatggta tataggttgg gcacggtggt tcatgcctat 82980 aatcccagga ctttgggagg ccgaggcagg tggatcactt gagctcagga gttcgagact 83040 agctcaagga atagagtgaa attctgtctc tacaaaaaat acaaaaatta gctgggtgtt 83100 gtggtgtgcg tctgtagtcc cagctacctg gggggctgag gtgggaggat cacttgaacc 83160 tgggaggtcg aggctgcaaa gagctatgat tacactaccg tgctccagcc tgggtgacag 83220 agcgagaccc tgtctcgaaa atatatttaa ggtgtacagt tttatgtttc catataccag 83280 aggctactgt cactgcttct attattatta ctactactac tactcatgtt accctttctt 83340 tggctgttac tttgtgccag gtactattct aagtacttac catgtttgat ctcatttaat 83400 cttcaccacc aaggaactga cccaaggtcc cacagctagg aaatggcaag ctgggattga 83460 gccgtgccag ctagccccgt gctatgcact gcttcacaca gaagctgccc ctccacccct 83520 gccgccttcc ttttcctttg ttcctttgtt atcagctggc cgtttccaga aacggttggt 83580 taacctctgc ctacctcaac cctcagtgat taaggggtga tatcgggcct caaatgactg 83640 acctttttcc tttgttgcag ctctcactga ttgtaattct gattgtaatt atatatttgt 83700 ttgcaccgtg gtttacttac tgtccatctt ccccagggca ggaggctgaa tggggcaggg 83760 gtctcgctgt ctcgtttgca gctccgtccg cggcacttca cccacatcct ggcctataag 83820 caagtcctgc ccatatattt gaccaataaa taaatgaatc attgacagcc gtgccccacc 83880 ccttcctcct ctctctgcca gccagcacct tggtctttca cagtgggtag agggcttggg 83940 ctgcaggtga aatggatttg caattccctg ataacccacc cgccgactgt gggagtgggc 84000 aggaaggtgt cagctcttcc ggatgaaaaa ccagcctgca atgcagtgtt tctacccagc 84060 ctacaaagca aacaccacta cctccacgcc ttaggttgga gaaattccgc tttacgacac 84120 agtcccatgg gcctcatgtc atttgtccct cctggcagtc ccgggggata ggtcgagcaa 84180 gcagtaggac aaacgactcc cattttccag gtgtaaaaac tgaggcttgg aggtgaaggg 84240 acttgcccaa ggtcatcagc tagaatatag cagggctggg attagaaccc aggtctgtcc 84300 gggtccacgg tctgatctga actcggcttc agttggtctg gaatgcaccg gctgcatctg 84360 atgatcttat taaagatctg tggctgtcag ggtcctcccc ctggaggtgc tgatttagtt 84420 ggtctgggtt ggggccctag gcacttggca cttaacaaac tccttaggtg attccagtgg 84480 acaggcaggg ctgggaactt catcacccct ccgagcccca gagcggagcc tgatccttag 84540 ccctggctgt gtatttgaat cactggagga gctttttatt tagcctttta tgatggaaac 84600 ataaagtaga cagcctagga taatgaacta ccatgagctc tttttctttt ctttttattt 84660 atttttgaga cagggtctca ctattaccca ggctggagtg cgatggcaca atctcagctt 84720 gctgcaacct ctgcctcccg ggttcaagcc attctcgtgc ctcagcctct tgagtagctg 84780 ggactacagg cacgtgccac catgtccggc caatttttat attttttgta gagacagggt 84840 cttgccatgt tgcccagact ggtctcgaac tcctgaactc aaagcagttc tcccgcctca 84900 gcctcccaaa gtgttggggt tacaagtgtg agccactgcg cccagctgcc atgagctctt 84960 taccatgcat tgcataggtg aacgttttaa tatgtatctc tgaaggacat ggatttgttt 85020 attttaaatg actttttatt tcgcaatagt ttggctcaca aaaagttgca aaaataacag 85080 agttcctgtt gttcattgct caactttctc taatgataac atctgaaaga taagaatttt 85140 aaaaactgta actgttgggc tgcatgtgat ggctcatgcc tgtaattcca gcactttggg 85200 aagctgaggc aggaggatca cttaagccca ggagtttgag accagcctga tcaatatagg 85260 tagaccttgt cttgacaaaa aacatgtata tgtgactgta atactaactt taataataat 85320 tcattattat caaatattcc agtaatccat tgtgtttgta caatggctca ttcttctatg 85380 atatcattct ttatgtttta gctgggattt ttttatggaa aagagtttcc ccttcatttc 85440 tttgatcact gatcactctg tggtgatcga ataaatgact gttttcctca gggaagcctt 85500 ctccaaccct ggtgaaccaa atgagtacat ttgggaaagg tggagaaaat acttgtttct 85560 ttccgctttt tctgcgttca aacaatgacc tggttcactg acaacatcag atgtttctct 85620 ttatttccag cgtcaatatg aaatttgtgt acataaacat gtaaggctgg gcgcagtggc 85680 tcaagcctgt aatcccacca ctttgggaag ccacggtggg cagatcactt gagtcaggag 85740 ttcgagacca gcctgttcac caacatggtg aaaccccatc tctactaaag atacaaacat 85800 tagcccagtg tggtggctga tgcttgtaat cccagctact taggaggccg aggcgggagg 85860 atcacttgaa cccaggaggc ggagtttgca gtgagccaag atcacgccac tggactccag 85920 cctgggcgac agagcaagac tccatctcaa aaaacaaaac aaaacaaaaa ccttgcttgg 85980 tatgtttcag cctgttgtac ttattctcct tgtcaaagct caaattgtcc ctcttttagc 86040 ctgcagcggc cacttctgct tggctcttga gccttttaac aatcctgttc atgcttagtt 86100 tccttgttgt ccggtgtgac aagatgttct tggcttacct tgcatatttc ctgcccagcc 86160 acttttccaa gaaaaatctg gaagtttaaa acaaaaacaa agcttcagtg ccccagtcgc 86220 acccagaacc agcttaatca gattgcctgg tgcgggtagg gcccggatac agtatttttt 86280 taaattttat ttttattttg tttgagacag ggtccctagg ctggagtgta gtggcacgat 86340 ctcagcttac tgcaacctcc gcctcatgga ttcaagcaat tctgcctcag cctcccgagt 86400 agctgagctt gcaggcaccc accaccacat ccagctaatt ttttgtattt ttggtagaga 86460 cgaggtttca tcatgttgcc taggctggtc tcgaactcct gaccacaagt gatctgcccg 86520 ccttggcctc ccaaagtact gggattacag gcatgagcca ccacacccag ccaggataca 86580 gtatttttta aaaagcacgc ccagccttga atggaaaacc actggacgag agtatgccac 86640 cttatcgggc tctgtaaatg ccttatatct gcacaaggct ggaactttga gtggagtcct 86700 tggctaaagc tttcattact gcctggtgac ctctcttccc tctgctgcta aagcttgtgt 86760 ttcagaattt agacccggat gcatccatgt tgaaagccag gctttgtctg tcatcccagg 86820 agctctgtat cggtcccttt ccttgcctgc atgttgttga cttggggctc atcttcattt 86880 ctctgggaaa tgagttcttt gatagcttgc ttagaatctc tcagtacttc ccattgccct 86940 tagaatgaag accaaaatat gtggcctgca gtgtagactg tgcacagcct ccagtgtaga 87000 ctactcaggc cccttcttgg ttcctggagt ctaccatgct ttcttctacc accgggcctt 87060 tgcacacact gctgtctgtt gggaatgcgt tgcctttcct tgttacttag ttctcatcta 87120 ctcacccttc aggtgccagc ttgactgtct gcctcggggg cgccttctct gaccttcgta 87180 caccagatca gcccccatgc acttactttg tctcattggt aatatttctc tcccttcagg 87240 acacacatca aggcccagaa gttgtagttt tgcatttgtt catgtgatca tttgatgcat 87300 gtctctctct ggagcctgac tctttggggc tcacatcctc actccaccgc ttttagctgt 87360 gggaccttga acaaatcttt tcatctctgg tccccagttt ttaagttaaa ttaaatttta 87420 ttttattttt attttgagac actcttgctc tgttgccagg ctgtagtgca gtcgttcgat 87480 catggctcac tgcaacctcc gcctcctggg ttcaagcgat tctcttgcct cagcctccca 87540 agtagctgga actacaggcg cctgccacca catccagcta atttttgtat ttttaggaga 87600 gacagggttt caccatgttg gctaggatgg tctcgatctc ttgacctcat gatctgcctg 87660 cctcggtctc cgaaagtgct gggattacag gcccagtttc ttttaactgc aaaacaggga 87720 tgatataata cttttattta tcttgtgagg tgaggatgaa gattaaataa ggtagtttgt 87780 gtaaagcact tagaaaagag ctagctacta atagtagaga atcttggcag gtattactga 87840 tgattactgc agtagaccac aagctccata caggcagggg tcatttctgt ttgtttagat 87900 ttgtatgcag ggtgcttggc acaagggttg tgctcaggaa atacttgttg gatgaacgaa 87960 tgaatgaagt ggagataata gtaataccat gtttatagaa ttccatgagg atataaaata 88020 atgcaagtat ataagctctt ggtagagtgt ctagcacata gtagatggtc aataaatatt 88080 cagtgactga atgagtaaag tggggacaat agtaataccc gctcatgagg ttgtcgtggg 88140 gatataaggc aaccctgtag taccttgtag aatgcctagc acatagtagg tgctcagaaa 88200 atatttgttg aatgaatgag tgaagtaggg atgacgttaa caccaactcc tagggttgtt 88260 gtggggatag aagacaaggc aggtctatag catgttgtat tgtggttgca catggtagac 88320 actccgttga ttgaaactgg aagagctgcc atgaatttct ttctcctggc tattaggaga 88380 gggtcctttt ggggtgcaga atggtgtgga gctgacgcta gtcctctgga aggaagagtg 88440 agcagctgac tacttgctaa gctctgacct ggatgaaaag tcaaatcatt cctttccctc 88500 ttcctcccaa acctgtgctt tctttccact agaatccctg cccagagtcc agcgcttcct 88560 tcctgtcgag gatcaccttc tggtggatca cagggtaagg ccaggccccc cagacctcag 88620 ggaggtggtg gggagtgaat gaatgaatga atgaacgaat gaacatgctc agctccccct 88680 ccccaacttc tccctccttt gctcttctgc agagttgtct tgaatctgcc tgtgctggcc 88740 atgtggtctc agagacacca actctgtccg gcagttccgt gaacttgaat gtgataaaca 88800 cgtgagccgt gagcagctga cacctctgca gaaggctttg cctgggacag ccatatgctg 88860 gactgctttt gctttagctt cagatttggg tttttaaaat attaggtata gttattattg 88920 acattgtccc cctcctgtcc cccacgcctt agaaaaataa tactgtctca ccacaggaag 88980 tgtgggttaa aaaaccacat gtgcagatca gcagtgcagg agacatctag aggtaaccag 89040 tgtcaccatt ttagtatgcc ttcttctggt cgtctttctt ttttttttga gacggagtct 89100 tactctgtca gtctcagctc actacaagtc tccgcctccc aggttcaagc gattctcctg 89160 cctcagcctc ccaggtagct gggattacag gcttgcgcca ccatgcccgg ctactttttg 89220 tatttttagt agagacagag ttttgccatg ttggccaggc ttgtcttgaa actcctgacc 89280 tcaggtgatc cacccgcatc gacttcccaa agtgctggga ttacaggtgt gagccaccat 89340 gcccagctac cttctggtcc tctttttgta tatctttttc tgcccgttgt taacatctta 89400 gtggggattg tttgaagaat ctttttttgc ccctaataag catcatcttt tttttttttt 89460 tttttttttg agacaggctt tcgctctgtc gctgaggctg gagtgcagcg gcacacttgt 89520 agctcactgc agtcccaatc tactgggctt aggtgatgct cctgcctcag cctcctgagt 89580 agctggggct acaggcacac tcccccatgc ccagcagatt tttgtacttt ctgtagagat 89640 ggggtttcat catgttgccc aggctggtct ccagcttctg agctcaagtg attctcccgc 89700 ctcagcctcc agagtgctgg gattacaggc gtgaaccacc atgcccggtc tcatccttgt 89760 cttaatgaca aacatcgttt taaaaaatta gatgttttaa ataatttctt caagttacta 89820 ttaaaaagca tcactgggac agttgatgta atttgttcat gactacagga ccccggatgc 89880 atgctaataa cattcattct tgttttggaa aattgtgctc tagttacata agagcatgtc 89940 ctggattgga agagaatacc tccagttttt cttgggtaaa ggcatgtaga ggctgtatgt 90000 taactttttt tttttttttt tttttttttg agatggagtc ttgctctgtc atccagggtg 90060 cagtgcagtg gcaggacctc agctctctgc aacctctgct tcctgggttc aagagattct 90120 cctgtctcag cctcctgagt agctgggatt acagggacct gccaccacat ccagctaatt 90180 tttgtatttt tagtagagat ggagtttcac tgtgttgtcc aggctggtct caaactcctg 90240 acttcaggtg atccacccac gtcagcctcc caaggtgctg agattacagg tgtgagccac 90300 catgccagcc ctttaactgt ttaagtggtt cagaaaaaga tgatgtgttt gcatgtgtgt 90360 gtgtgtttgt gtgtgcatgt caatggatac agacagagaa tgatactgca aacgtggcaa 90420 cgtgttaaca atggtgagtt gagtgaattc ttagtatgat ttgagtaatt tttctataag 90480 tttgaaatta ttttagaaca aaacatgaaa gtattttacc ttttattata aaagtgttta 90540 gtctgctggg cacggtggct catgcctgta atgttagcac tttcagaggc caaggtgggt 90600 ggatcacctg aggtcaggag ttcgagacca gcctggccta catggtgaaa ccctgtctcc 90660 actaacaata caaaaattag ccgggcagca cacgcctgta atcccagcta cttgggaggg 90720 tgaggcagga gaattgctag aatacaggag gcagaggttg cagtgcactg agatggcgcc 90780 attacactcc agcctggatg gagtgacata gaaagattaa tataataaaa ctcaataatc 90840 tcatcaccca gatttcatgc ttactaatgc tttgtcatgt cagccttttt attttttaat 90900 tttttccttc agcctatttt tttttttttc tttttatagg gtctgactct gttgcccagg 90960 ctggagtgca gtgacacaat gacggctctt tgcagcctcc acctcctggc cttgagcaat 91020 cctgccacct cagcctcccg agtagctggg actacaggtg cgagccatca tgactggcta 91080 atttttttat ttttactttt cgtagagata gtctccctat gttgtccagg ctggtcttga 91140 actccagggc tcacaaaatc ctcccacctc ggcctcccag agcgctagga ttatagacat 91200 gagctaccgt gcctggccca tatcagcctt ttttaattta aaattttaaa aagttggcgg 91260 ggcacggtgg cttatgccta taattccaag acttcgggag gccaaggtgg gagggttgct 91320 tgagcccggg ggttcaagac cagcttgggc aacataggga gactcttgtc tctacaaaaa 91380 taaaaaataa aaaaaaaatt agccagtcat aatggcttac acccaaagtc ccagctactc 91440 gggaggttga gatgggagaa ccactctaga ccgggagctg gaggctgcag ggagctgcga 91500 tcgcaccact gtactccatc ctgggtgaca cagcgagacc ctctctccaa gtaaataaat 91560 gaatgaacga ataataaaaa ataaaaaaga gctatcctga tacttcgctc ctaaatcatc 91620 tttttttccc taagtctttt gtatgcacca ctaaaaaaaa aaaaagccat ttttcctgca 91680 tgacccaaca gaatgagctg taattagctt gtaatatatg caaatgtcca tctgcattct 91740 gacttcccaa gctgcatggc tgccttcatt tgcagcgggc agctgtgctg cagaggggag 91800 cagcatcagc aggcgtgtgg agtgagtgag ccccgtcctc cccctcctcc tgtcattgac 91860 tctcattgcc taaccccctt gtgtcttggc cccaggttga ttgtccgggg ctaccgccag 91920 cccctggagg gcagtgacct ctggtcctta aacaaggagg acacgtcgga acaagtcgtg 91980 cctgttttgg taaagaactg gaagaaggaa tgcgccaaga ctaggaagta agtgtgagtt 92040 tccttgtcct ccaggatgcc ctggtcacct cctttccact cctgtggcct caatccagga 92100 tggggccctg gcagtgctgc ctgttactag ctttgtggtt ctgggcaaga tgcctcactt 92160 ctcctcctgg cctcagtttg cttttctgcc aaatggggta ggatctcaca tgtcattaaa 92220 gcaactgggc agagaaaaga agaaagaagc tgggtgcggt ggctctcgtg tctaatccca 92280 gcactttggg aggccaaggc aggcggatca cttggtcggg agtttgagac cagcctggcc 92340 aacatggtga aaccctgtct ctactaaaaa tacaaaaatt agctaggcat ggtggcaggc 92400 gcctgtaatc atagctactc aggaggctga caggagaatc acttgaaccc aggaggcgga 92460 ggttgcagtg agctgagatt gtgccactgc atactagcct gggagacaga gtgagactcc 92520 gtctcaaaaa aaaaaaaaga agaaaaatgt tgtccaaaca ggcagttgat gctgtctgcc 92580 atggcgcgtg actatccctc cttgagtcag tctcactttt ttctgtctct ttctgagcat 92640 ctggcatcct gcatgttctt gctgtttgaa tgttctgtcc aacatgccca gctgaccacg 92700 taagtctgtt tagccaaaga agccccattt gagggtgatt ttggctgtac tggattttag 92760 gctctacccc ctatgtaagg cgtgccccac tgcaccacct ctgtcactct tcgggaatca 92820 ggccagtgcc tcccctgcac ataccttaac tcatcaaatc tgagacacca ttagttgcgt 92880 gatgcgttat tattctatgt aacagtaaga aagaaaagca gctgccaatt aaacaaggac 92940 ataagacttg tctcgagccc ggacgaactg gaacatgaaa ttgtgggtga catgggggca 93000 gtggattgcg gccatggggg tagtagaatg gctgtttttg ttcctgttgc ctgttctggg 93060 gtaagtttac tacgataaac tgtggtgggg ccagtgtggt gcattggatt ccccacagac 93120 ccattggcct tacagggaaa aaccccagac cggggttctg ttcctcattc tattccgggg 93180 atgcccagga tacaggcctt cagtcagacc cagatggtgg gtgggaatct ggacatccat 93240 gtgccagcca ctaggacatc agcagaggac ctcgtgactc cggtcggagg ctgtttgggt 93300 ggtccaggtg atgggagaaa ttgtctcgtg ggaggcagat agagcttggg cctctgtgac 93360 tgagcattgt aaggaaatgg cccatgtcca tgacccagtt gaaggttttt ggcaggcaaa 93420 ggtggggtcc ctgtttatta cagttcttca tggagacaga actagtagga tggatggatg 93480 gatggataga tgatagatag atggatgata gattgataga tgataggtag atgatagacg 93540 gatagttggt ggatgtatac atggtaggta gatggataga tgatagatag atggatgatt 93600 gatagatgat ggatggatgg atggatggag gatgagaggg gatctactag ggaaactgga 93660 tcatgtgatt atggaggctg agaagtccca ccctaggtca tctgcaacct ggagaaccca 93720 ggaagctggt agcatggctc aggcctagtc caaaagtctc agacccaggg aagctgatgg 93780 tggaattctc agtccatagt caaaggcctg agaacctgga gtcattgggt aagtcccaga 93840 ggccagaaat cctggagttc tgatgttcaa gggtgggaga ggatgacatc ctggctgcag 93900 aagagagagt gcctgcattt gccattactc tgactttttg ttgtgtccgg accctctgct 93960 gattgggcgg tgccacccac atggggcgag gatggatctt ccttagtcag tccactcatt 94020 caaatgccag tctcgtctgg aaacatcctc acagacacac ccagaaataa cactttaaca 94080 gcaatctggg tatcccttaa cccagtcaac ttgaccccta acatcaccca tctcatctgg 94140 attccttcag cctcacctgc agcatccccc ccgctaagca ggccacattt gtagtgtggg 94200 cttcagcatt cctcatcatc cacgcctctg ctgatcacct ggctcggctt cctctcatgg 94260 aagacggatg cccacctttg tgtcccctgg agcttgtcag gagagcaggt tgctggagac 94320 accatgggag aggccaatat cacagccttg ggaggaggac agagtttgaa tccagaagct 94380 cctccactgg cctggctctt aatccactga gcagatgaaa ctgactgctg cttttgtgct 94440 tagcgacgtt tagtccctga gggttcagag agtggaacaa aagagacaca ctctagttgg 94500 gtgccatcga cattctatat gggagacagg acgttggttg tgaaacatgc attgacaaga 94560 agctttggag aatgatggtg ttggggtgag ataaaaatga ggaaatgagg gtgagagtaa 94620 ccgaggaagc ttttgtgtgt gtgtgtgtgt gtgtgtgtat gtatgtgtgt gtgtgtgtgt 94680 gtgtgttttc tttttttttt tttttttttg agatggagtc tcattctgtt acccagggtg 94740 gaatacagta gtgtgatctc ggctcactgc aacctctgcc tctcgggttc aagcaattct 94800 tctgccccgg tctcccaaag tgctgggatt acaggtgcat gccaccacgc ctgactaatt 94860 ttttgtattt ttagtagaga cggggtttca ccatgttggc caggctggtc ttaaacttct 94920 aatctcaagt gatcctcctg ccttggcctc ccaaagtgct gggattacag gcatgagcta 94980 ctgtgtccgg ctgagagagg tgttttagat acagtggtca aaggttctac ccagtgtggc 95040 catgaccctt ggtgagcatg tgcctgtccc tccctaagtc tatctctggc tgttttcgag 95100 cctctggcat cctgagtgtt actgcttttt gaagtgtttt tgttcaacat gcccagctga 95160 ccatgtatga ttgttttgag aaggtcacat ttgagcagag acttgcattg gagggagtga 95220 gccttgtgtg tatctgggga aggaagggct ttccaggtag agggagcagc cagtgcaaag 95280 gctctgagga cactcgtggt gcatcagggg gcttgtgtgg cttgaggaaa gtgagtgagg 95340 gggagaaagg gaggagatga agcaggagaa ggatttgcag gggtctcctc tgagagttaa 95400 ggtgggattc caggtgcagt gagaacacag gcgcaggttt tctgcagggc agtggtgtga 95460 cgtgagttct gttgtttgtt tgtttgtttg tatgtatgta tgtatgtatg tatgtatgta 95520 tgtatgtatg tattttagag acagggtctt gctctgttgc tcaggctgga tggcagtggc 95580 atgataacag ctcattgcag cctggaaatt ccgggctcaa gcagtcctcc cacctcatcc 95640 tcccagagta gctgggatta caggtgcaca ccaccatgcc tggctgatga attaattaat 95700 taattttata ttttatattt gtttttttga gatggaattt tgctcttgtt gcttaggctg 95760 gagtgcagtg gtgctgtctt ggctcactgc aacctccacc ccccgggttc aagcgatttt 95820 cctgcctcag cctccggagt agctgggatt acaggaatgt accaccatgc ccggctaatt 95880 gtgtattttt agtagagatg gggtttctcc atgttggtca gtctagtgtc aaactcctga 95940 catcaggtga tctgcctgcc tcggcctccc aaagtgctgg gattacaggt gtgagccact 96000 gcgcctggcc tttttaaatt tattttattt tattattatt atactttaag ttttagggta 96060 catgtgcaca atgtgcaggt tagttacata tgtatagaga caggtctcac tgtgttgccc 96120 aggctggtct ccaagtcttg gcttcaagca gtcctcctgc ctcagcctcc caaatagctg 96180 ggattacagg tgtgagccac cacacccagc tgagttctgg ttcataacaa cccaggctgt 96240 cctggggaag gtggatattt agggacaaga gtgaaggcag ggagaccagg gtgggaacct 96300 caagggctgt ccatgaagtc ccttcatgcc tcaccgggag ccgccattgt atttatttat 96360 ttattttttg agacagggtg tcactctttt gtccaggctg gagtgcagtg gcacgatctc 96420 ggctcactgc aacctccatc tcctaggctg gagtgatcct cccacctcag cttccctagt 96480 agctgggact acaggcacgt gccaccacac ctggctaatt tttttttttt ttttttgtag 96540 agatgatatc tcgccatgtt gcccaggctg ttctcaagct cctgagctca agcagtccac 96600 ctaccttggt ctcccaaagt gctggtatta caggcgtgag ccactgtgcc tgactggagc 96660 ctccattttt cacccagagc attttctgag aattcagtga gatatatgat atgataagct 96720 gtgccctagc cctgagtaca tgctgggcag gttttaattg tacaagtttt atttattcat 96780 ctgtacactt tgatcttgcc agggaggatg tggtgagaac tgggtcttgg ggcttgaaag 96840 cgggccacct gagaagggtc tggctctgtg agtaccttgg tgtttagaga tcctcagcgt 96900 ggagccaggg gatcatttac ttgggacatt ggtagacgga tcgcttgctt tattcccaga 96960 ggcataagcc agatctggca cctgtaaccc ctgtgaacct ggagagagtg agaaggaaaa 97020 ccctgtccta ggctggaatt tcctggtgtg gccccttaca ctcagatccc ttttgttaac 97080 cagagaaagg aatgcagctc gtgcagctct gggctgctgg gtatcctagg ctcggggatc 97140 aggtgatgga cgccagggct gggggctctg catggcttcc tggatccttt taccacctct 97200 cttcacccat gagtgactcc ttctcaaaag tcaggtgtgg ctgggcatgg tggctcatgc 97260 ctgtaattgc agtacgttgg gaggctgagg cgggaggctc acctgagttc atgagttcga 97320 gaccagcctg gccaacatgg tgaatccctg tctctgctaa aaatacaaaa attagccggg 97380 tgtggtggcg ctcacctgta atccagctac aggggggctg aagcatgaga attgcttgaa 97440 ttgtttggat ttaaaaaccc agtgcttcat tggtttgtgt gtagtggttt tatgttctct 97500 tttgtgtatg gccactcaga gcttagggcc attttggact gtggtttctg ctggcatgaa 97560 tgtgaaatgc ttctgtgact ctggaagagt ttggcagttt tttttttttt tttttttaag 97620 ttagacacag tgaacatacc accagtcacc cccttcccag gcatccagcc aacagagctg 97680 agaacatatg ttcataaaag gctggtacag gaatgttctt agctactttg tgataaccca 97740 aactggaggt aagccagaca tctattagca agtgaacaga cagatgcacc agttatgtac 97800 atctgcacaa ctgaatacta agtgatgtac aagaacgaac tattggccgg gcacagtggc 97860 tcatgcccat aatctcagca ctttgggggc ccaaggcagg cagatcactt gaggtcagga 97920 gttcaagacc agcttggcta acatggtgaa accctgtctc tactaaaaac ataaaaatta 97980 gctgggtgtg gtagcgcaca cctgtaatcc cagctactcg ggaggctgag gcaggagaat 98040 cgcttgaacg caggaggcgg aggttgcagg gagtcaggat cgcaccattg cactccagcc 98100 tgtgtgatag agcaagactc catctcaaaa aaaaaaaaaa aaatccctat aagataaaga 98160 ctactttttt ggtgacagct ttattgagat attcatacac cgcacaattc atgtatgcag 98220 aacatacaat tcactgattt ttagtgtgtt cacagagttg tgcagtcatc atcacagtca 98280 attttattta tttgcttttt aagacagagt cttgctgtgg cgctgaggct ggagtgcagt 98340 ggcacaacct cggctcattg caaccccctc ctcctcctga gttcaagcga ttctcctttc 98400 tcaccctccc aagtagctgg gattacaggc aaccgccacc atgcctggct aattttttat 98460 atttttagta gagacaaggt tttgccatgt tggtcagggt gttctcaaac tcctgacctc 98520 aagtgatcca cccgcctcga cctcccgaag tgctggcatt acaggcatga accactgcac 98580 ccagtcaaaa aaaaaatttt tttttagaaa tagggtcttg ctgtgttgct ctggctggct 98640 ggactgtttt tttttttttt tttttttcca ctgatgtata tatgcctatc cctttacctg 98700 tcttgatgat tgttgttctt ttttttgttt tgtttttttc tttttgagac tgagtctttt 98760 tgcccaggct ggagtgcaat ggtgtggtct cagctcacca caacctccgc ctcctgggtt 98820 taagcgattc tcctgcctca gcctcccaag tagctgggat tataggtatg tgccaccatg 98880 ccgggctgat tttgtatttt tagtagagat gaggtttctc catgtttggt caggctggtc 98940 ttgaacctgc cgacctcagg tgatctgccc acctcggcct cccatagtgc tgggattaca 99000 ggcgtgagcc actgcgccca gcctattgtt gttctttctt tttgagatgg agttttgctc 99060 tgtcacccag gctggagtgc aatggcctga tctccactca cagcaacctc cacctcccag 99120 gttcaagtaa ttctcctgcc tcagcctccc aagtagctgg gattacaggc acctgccatc 99180 atgcccggct aatttttgta tttttagtag agatggggtt tcactatgtt ggtcaggctg 99240 gtctcaaact cctgacccca agtgatccag ccaccttggc ctcccaaagt gctgggatta 99300 caggtgtgaa ccaccactcc tggccatgat tgttattttg tattgttttg aaatcaggaa 99360 gtgtgaatcc tccaacttga ttcttatttt tcatgattgt tttgactgtt ctggatcctt 99420 gagtttccat gtgaatttta aagttagctc ataatttcta cctggcagcc agctgggctt 99480 ttgatgggga ttgccttgac tctagatcag tttggagcca tcagttttct aagtctttaa 99540 cttattcaac tcgtttaatc ttacctacct tggaggtagg tcctactttt atcctcattt 99600 cacagaggag gaaactgagg cccagagagc ttaaggacct tgtctgaagt cacgcagctg 99660 gccagtggcc aagccagacc ttgagccggt ggctctggag cccgtggctc tggagcccgt 99720 gtttgtaacc actgtgctga gctgcctctt tccctgggct tgttgtcttt gactctgcct 99780 tccctgaagg gtgacattcc ctggccatgt ccctgtggta gggggctgca tctctggcag 99840 accccacaac ggcttcacct ccttgtgttc caggcagccg gtgaaggttg tgtactcctc 99900 caaggatcct gcccagccga aagagagttc caaggtggat gcgaatgagg aggtggaggc 99960 tttgatcgtc aagtccccac agaaggagtg gaacccctct ctgtttaagg tgttatacaa 100020 gacctttggg ccctacttcc tcatgagctt cttcttcaag gccatccacg acctgatgat 100080 gttttccggg ccgcagatct taaagtaaga ccccttccct cccaggtggg ctccattttc 100140 cctccttggc tttgatcttt cagttgcatc agtcataacc ctggggtcat gctgtgtcct 100200 gaagtgggct catagccaga tgtctccatt tttactttag cttttttgaa aaaaatagag 100260 acagggtctt gctttgttgg tcaggctggt ctcgagctcc tgacttcaag cgatcctcct 100320 gcctcggcct cccaaagtgc tgggattgca gatgtgagcc atggtcactg cctagcttta 100380 ctttatgctt tacttaatta ccatattagt gaagaccaca tcgtttgcaa gtaacagaaa 100440 cccactaggc tcccctaaaa cccaaatggg gaggatatgg cattgtcttg ggaaaccaag 100500 agcaaggaaa tgccagcaga tctcatgaaa aaactgcaac cagggttggg cgcagtggct 100560 catgcctata atcccagcac tttgagaggc tgaggtggga agatcacctg aggtcaggag 100620 gtcaagacca gcctggccag catggtaaaa ccatctgcta aaaatacaaa aattagccgg 100680 gcgtggtggt gcacgcctgt aatcccagct actcaggagg ctgaggcata aaaattgctt 100740 gaacccagga ggcagaggtt acagcaagct gattgcatca ctgaactcaa accttggcga 100800 cagagcaaga ctttgtctca aaaaaaaaaa aaaaaaaaaa aagaataaaa acaacaacaa 100860 aaaactgcaa ccaggaactg gggagtcaga aaggaagttg cctctctcct acctggctct 100920 ctgctgctct gtgactcagg ggctacacat cccttctctt ttcctcccta cctctttacc 100980 tcgtgttccc tatgcaattc ctttgggtga cttgctggtg atgagatata gctagagcaa 101040 ttagtgcaca accccaaggc agaggcctct tttatgagca gtttgggtca cctgcacagc 101100 cagatcacca ctgtggactt gtttttccat ctatgaaatt gaagtgatag tgtctagctc 101160 atctggctca ggagaaagtt gcagtgccaa cactgaagct ctcttccctg cccccacgtg 101220 tcacaagtca ttccaggccc tctctttgct cctttgcagg ttgctcatca agttcgtgaa 101280 tgacacgaag gccccagact ggcagggcta cttctacacc gtgctgctgt ttgtcactgc 101340 ctgcctgcag accctcgtgc tgcaccagta cttccacatc tgcttcgtca gtggcatgag 101400 gatcaagacc gctgtcattg gggctgtcta tcggaaggta ggggacgctg tgccattggc 101460 atgtggcccg acttccacat cccctcctgc agccctgggt tactctgggg ccagcgtggg 101520 gatttccagc ccagcttctg gagcagtagg atgagggtag cttccgtgac cttaggtggc 101580 agggacagca cgcatcaggc attgtacgtt aggaaagctg atttcaaggg tgggcgtgta 101640 gatgtctttg tgtatcagct gtgagtaatt gagtttctta gatggatcag tggcccttgt 101700 tgtggggaaa tccaagtttg gatcctcatt ctgctgttaa cattctgtgt ttcagcttgt 101760 tgtcactctt tttttttcgt ttttttgaga ccaggtctca ctctctcccc cagactggag 101820 tgcagtggca tgatattggc tcactgcaac ttctgcctcc tgagttcaag cgattcttct 101880 gcctcagcct cctgagtagc ggggactaca ggcgcctgcc accacgaccg gctaattttt 101940 gtatttttag tagagacagg gtttcgccat gttggccagg ctgatcttga actgctgacc 102000 tcaggtgatc cgcctgcctc agcctcccaa agtgctggga ttacaggcat gagccaccgc 102060 gcccagcctg ttgtcactct taatttgaac tgagcaggtg gcacattcct tgcatggtaa 102120 gagtatgtag caggcatttg tgtacatcca atttcaaagg acctaaatta ccttcttgat 102180 ccctataaat tttttttttt ttttgtctcg aggtcaagga aactgcttgg ctcctaggtt 102240 aggaagagac agtcttgcag gtacttgatg aactagagga gtgattctca ggcctgtctg 102300 tgaattagac tcacctgggg agcttaaact gatgcaggcc aggcactgta gctcatgcct 102360 gtaatcccag cagcttggga gaccaaggtg ggggaatcac tggaggcttg gaagttcaat 102420 accagcctgg tcaatatagc aagaccctgg ctctgcagaa aatttaaaaa aattagccag 102480 gtatggtggt gcgtacctgt agtcccgtct actcaggaga ttgagttaaa agaatcactt 102540 cagccccgga gttggaggct gcagtgagtc ctgatagcat ccctgcattc cggcctgtgt 102600 gacagaatga gaccctgtct gaaaaaacaa aaaaacttcc tgacacctag gttgcaccag 102660 accagtgaaa ttgcgattgc tgtggtggca cccaggtgtc attgtttttg ttttttattt 102720 atttttatgt tttgagacag ggtctcgctc tgtcacccag gctagagtgc agtggcatga 102780 tcttggctca ctgcagcctc cacctcctgg gctcaaacga tcctgccacc tcagcccacc 102840 acgtagctgg gcccagaggc atgcatcacc acgcctgcta atgtcttagt gtttttaaaa 102900 ctcacgaggt gatagtgtgc aatcatgttt gagggctagg gacattttcc cccaccaggg 102960 cacgtttggc aatatctggg ggcattttcg gttgtcccaa ctgggggcga gggcatgtag 103020 tgggtcgagg ccaggtattg ctgctaaaac tcctacagtg cgcaggacag ccccccaaag 103080 aattatctgg ctccagatgt caagaatgcc aaggattaga gaccctggcc cacaccctca 103140 gtccttcagt gggatctggg accagtagca ctgacacagc ctggaagcgt agaaatgcag 103200 aatcccaggc cacaccccag acttgcagaa tccaaaacaa ctccccccac cccccaccac 103260 tccccccaga aaaacccggc cgcatgtgtg cacattaaag catgcgaagc cctggtttcg 103320 aggacaccta gggtcccttg ccaactgatg agttcaaggt tgggaggcac tgagcaccgc 103380 ggataagaat gtgggctttg agatgacaca ggcgtcctgg gcagacagat aggtcgggag 103440 gggaggagga gagatctgcg gcatttctgc ccctgagagt ctccttcctc tccgtgggtc 103500 tggagggaga gtcaggcctc ttcagctgcc acactcaccc accttccctc tcctttgtcc 103560 cacaggccct ggtgatcacc aattcagcca gaaaatcctc cacggtcggg gagattgtca 103620 acctcatgtc tgtggacgct cagaggttca tggacttggc cacgtacatt aacatgatct 103680 ggtcagcccc cctgcaagtc atccttgctc tctacctcct gtggctggtg tgtgtttaac 103740 gccgtttccc tttgcatgca gggagggact tctacgtgtg ggcagtgggc cgagggagtg 103800 ggtgttgatg gtaatggcat gtagagctcc ctggcagttc cggctgtggt tcatatttta 103860 ttttccagcc tgttaaccaa ttcctcagta ttttgttcct ttcctgaatt gtcaggttga 103920 tgttctcctt ggtggcatgg cgttttcatt ttctcttttc cttgacagtg tcagtaatta 103980 actaccctac aatggacgac acatcatatt tctccccttg aatcctccca aacgctaacc 104040 agactcactt attcattagt ccctaattat ggtggtcaaa attctctcaa ttgcaaggga 104100 tataaatctg tcttaaagta gcctaagtgg ccggttgcag aggctcacgc ctgtaatccc 104160 agcactttgg gaggccgagg cgggcagatc acctgagatc aggagttcga gaccagcctc 104220 aacgtggaga aaccccgtct ctactaaaaa tacaaaatga gctgggcgtg gtggtgtatg 104280 cctgtaatgc cagctacctg ggaggctgag acaggagaat tgcttgaacc tggaaggcgg 104340 aggttgcggt gagccgagat tgggccattg cactccagcc tgggcaacaa gagtgaaact 104400 ccaattccaa aaaaaaaaaa aagtagccta agtaaataga gggaactttg gggctgcatg 104460 tatctcagaa atctggggac tagcttcagg tgtggattga tccaggagat caagcaatgt 104520 tgtcagtact cagtttcacc cactgccctg ttgtcctctg agttaacatc attctcagtg 104580 gtacttccct acatggctcc gtagctttgg gctgataaca tcctgataga taaaggtgcc 104640 agagaaaaga caaggcagca tttctctgca cagccagagt cagtctcaga gagcactctg 104700 attagcctgg cttggtccta ttcacacccg tgaaccaatc actgtggccc aggaggcaga 104760 gttctctcat tggccagcct gggtcacatg tcctctccca tggcagaaga gatgtgattg 104820 acagcccttc catgtggaga gggagagttc ccaaaataaa atgataagca aagaggctca 104880 tagcacaaca catgccttgt gctttgctac ctctggatct ttgccacgta cctttccttc 104940 cttcttccta attgatgaaa gcctgctcat cccccaaggc tgtaacaaac actacttcca 105000 ttgatttacc ctcccttctc aattagatgg acttcttctt ttgaattttg agtcccaata 105060 actttagtat aggaactcat ctaataatac tttctgaaat agtttttttt gttttgtttt 105120 tgttttgaca tggagtcgcg ctctgttgcc caggctggag tgtggtgtgc catcttggct 105180 cgctgcaacc tctgcctccc agcttcaagc aattctccta cctcagtctc ccgagtagct 105240 gggactacag gcttacacca ccacgcccat taaattttct tttttttttg tatttttagt 105300 agagacagtg tttgatcatg ttggctaggc tgatcttgaa ctcctggcct caggtgatct 105360 accctctgtg gtctcccaaa gtgttggaat tacaggcgtg agccaccgtg cccagcccac 105420 tccctgaaat agttttgttt tgtttttttt gcatgctcag tgtactgcct cctctttgaa 105480 gggtaacatg ttagctactt gcagacatat agcagctgac ttttgtgtct tctgtgggta 105540 caaccccagc agggcctgat gcataatggg cacagctcaa attattatct gttattgaaa 105600 gagaagggct ggacgaaatg gctcatgctt gtgatctgaa cactttggga ggccaaggcg 105660 ggtggatcat ctgaggccag gagagcagcc tggccaacat ggcaaaaccc cgtctctact 105720 aaaaatataa acattagtca ggcatggtgg tgtatgccta taatctcaac tacttgggtg 105780 gctgaggcag gagaatggcc tgaatccggg aggcggaggt tgtattgagc tgagtttgta 105840 ccactgcata ccagcttggg caacagagcg agactctgtc tcaaaaaaaa gaaaaaggaa 105900 gaagaaaaaa ttactggttt atttggctgt agtttggttt ttttttgtac atttgtagag 105960 cagaaggtga gtaaagtgtt tctaataata aaactcagaa aaaacaccag aatttaattg 106020 tctaataggc tgggtacaga tataggtggc atgcgcctgt aatccctgca ctttgggagg 106080 ctgaggtgga aggattgctt gaagccagga gtttgagacc agcctgggca acatagtgag 106140 accctgtctc tacaaaaaaa aaaaaaaaaa aaaaaaatta gctgggcatg gtggtgccta 106200 cctgtggtcc cagctaccgt ggaggctgag gcaggaggat tgcttgagcc taggagtgca 106260 gaggctgcag taagctagga tcacaccact gcactcctac ctgggtgaca aggcaagacc 106320 ctgtctctag aagaaaaaaa aaatctaaat aaagtgtctt ttcaagcagg tgtcttgggg 106380 agtccacttt tgtaaaagtg ctactatggg aaaaatattt ttggaacatt tgttctagaa 106440 ctgccttcag gattggttta tgaaccgtta agaaaattgt ctaacatcac gttttgtttt 106500 agatggtagt tgcttgagct cagcactgtt gacacttggg gccagacagt tctttgttgt 106560 gggggctgtc tttttttttt gttcttgtta ttgttttttt tgttttttta agggacagag 106620 tcttgctctg ttgcccaggc tggagtgcag tggtgcgatc atagctcact gcagccttga 106680 attcttggcc tcaagcagtc ttcccacttt gtcatctcat ctagctgggg actacaggtg 106740 cacgccacca tgcctggcta agttatttat ttttttgtag aaatgggggt cttgctgtgt 106800 tgcccaggct ggtctcgaac ttctaccctc aagctatctt accactttgg cctcccaaag 106860 tgatgggatt acaggtgtca gtcactgcac ctggccacaa ggctataagt taatacagca 106920 aaattagcaa ggaattaagg cacacatggg gcggtgttca agagaagcca ggtgcaggct 106980 tccaggagtc cccagcagag tcacaggttc actaattctc tggcaaccat gatgattatg 107040 tgtgtgaaat gttgccaacc agggaagctt ggtaggagct cagttcctgg gtttgtatta 107100 ggggcaggtc acataagcag cctttgcttg gcacatacca aaagtctaga ctcccagagg 107160 gaaagcggtg ttcagcataa accatattgt ttgtacaaac agttgaggca cactgagcta 107220 ctctacccaa ttctgttaat ggtggaaacc ctgtaagtat gcagacacta gccaagggct 107280 aaacttgtaa gcagccttca agcaggaaaa gcaatcaggt ggtcgtgttc acacttttct 107340 gcttactacc ttattacctt tctaaaaatc taagctgggt gtgatggctc gcgcctgtaa 107400 tcccagctac ttgggaggca gaggtgggaa agtcgcttga gcccatgagt ttgagaccag 107460 cttaggcaac atagtgagac cttgtctcta caaaaaatca aaaaaatagc tgggcatggt 107520 ggtgtgagtg tagtcacagc tacttgggag gctgagttgg gaggatcact tgagcccagg 107580 agatcgagag cagtttgagt aacatagtga gaccttgtcc ttacaaaaaa ccaaaaaaat 107640 tagctgggca tggtgatgtg actagtcaca gctacttggg aggctgaatt gggaggatcg 107700 ctggagccca ggagttggag accagcctgg gcaatgtagc aagacctaat gcttacctgt 107760 agtcccagct actttggagg ctgaagtagg aggatcactg atgcaaatag ccactgtact 107820 gcagcctggg caacatagcg agacctcatc tcctaaaaaa aaaaaaatta gaatcctgca 107880 gttgtaattt gcaaaactca tgtggcccca agggcttggg agaaaggagc gtggacctgc 107940 ttattcttca agggattggg aggacctgga gagatgctca ggaatgaaac cacaggctct 108000 taacacccta ttgtggggta aaagtaacac accttgccct gaacttggtc agcagcatcc 108060 acgtgggatg gatcaaccgg ggaagctgtt acgggccctg ttttcttctg tctggtgagt 108120 gatgaagagt ctcctttcct tccttagaat ctgggccctt ccgtcctggc tggagtggcg 108180 gtgatggtcc tcatggtgcc cgtcaatgct gtgatggcga tgaagaccaa gacgtatcag 108240 gtaaggcatg tgtctctgcg ggcccccaag ccgggcccta ggcagaggcc tctccatgag 108300 gattttagtc cagttccttc tgctctgtcc ctggggttct cagccttgcc tgccagttgg 108360 actcacttgg ggagccttaa caaatgctga tgccccggct gcatatctgg gattctgatt 108420 cacttattgt gggtggggtc tggacatcaa gatgttttaa agcttcccag gtcattatat 108480 tgggcagcca agattgagag ctcctgacac atggttagac cttgtaggcc ggtgactgga 108540 atcagaaggt ctgtgagcct ctgagaaagt ccttgtttcc cacggtcttg tttattatgt 108600 gtatgtgtga ctcagctttc aagagttgag tacaaattac cccctacttt tttccccctt 108660 attagctctt accttatagg atacatgctg ttaatctctt tatttaaatt aaaataatta 108720 atttctaaaa tggggccttg ctgtgttgcc caggctggtc tcaaactcct gggcttaagt 108780 gatcctgttg cctcagcctc tcaaagtgtt gggattacag gtgtgagcca tcatgcccgg 108840 ctttcagctt tttatttttg gagatatttt gtattttaaa aagtttgaat acccaagtaa 108900 tagagtgatg tttcttatta taaaaaagtc caaatcaagc cgggctcacc cctgtaattt 108960 cagcattttg ggaggccaag gtgggtggat cgcctgagct taggagttca agaccagcct 109020 gggaaacatg gtgaaacctg tctctaccaa aaatggaaaa gttagctgca tgtggtgatg 109080 cgtgcctgta gtcccagcta cttgggaggc tgaagcatga ggatcacctg aacccaggag 109140 gtcgaagctg tagtgagcca tgattgtgcc actgcacaac agagtgagac cctgtctcaa 109200 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaagt ttaaatcgta caaaagtaca 109260 taaattaaaa ggggataccc ccttccctac tctctcaacc actgcaaata tatagaagca 109320 aatccttcta caactttcta cgtatgtata tacagacctg attaatggta tagtttggtt 109380 tgtttttata tatgtgggtt tttttttttg tttgtggaga tggagtctca ctttgttgcc 109440 caggctagag tgcagtcgta cgatcttggc tcactgcaac ctctgcctcc cgggttcaag 109500 tagttctcct gcctcagcct cccgagcagc tgggattaca ggtgcccacc accacaccca 109560 gctaatcttt gtatttttag tagagatgag gctttaccac attggccagg ctggtcttga 109620 actcctgacc tcagatgatc cacccgcctc ggcctcccaa attgctggga ttacaggcat 109680 gagccaccat gcctggccat tatatatgtt ttgtgtgtgt gatattatta ccatatctgt 109740 ttttacctaa atgggcccac gtggcagcat gatttttgtc ctttagcgcc ctgctttggg 109800 gacctctctg tgctgtgccg tatagcttca attcattctt ccaacccggt gccttttggt 109860 ctataatgga gatggtgcag tttatttctt tgctcttctg ttgatggata tttatggtgt 109920 gctgtggaat ttcaaatggg agcactaggc tgcactgacg ataccacagg gagatgagtt 109980 tcaggacatg ggcctgttgg aaggagaggc ctcacgtggt agggttgggt gggatgggtg 110040 aggcaggggc tttaggattg agtcaccctt cagtctcttg atgtgtagga tgccctgagt 110100 ggcccgactc aacccatttc agtccctggc ctccagatca tgtagcttat attcttccca 110160 tctgtgaccc ggggatgact gtagcactaa atgataagag ttcttgtgat tgttaagtgt 110220 ctgaatacat gtaaaatgct tagaaaagtt gctgggatac acaaaatcct gggtggtagt 110280 aaaagtattt aacaactgca ctgcacaagt atccactatt tggaaccagt gctagccagt 110340 acagaaacat ttcactattt taacaaccat gggccaggca caggggctca tgtctgtaat 110400 cccagctctt tgggagcctg aggcaggagg ttggcttgtg gccaggagtg caagaccagc 110460 ctgagcaaca tagcaaggtg ccatctctac aagaaataca aaaatgaact gggtgtggtg 110520 gcatatgcct gtggtcccag atactaagga ggctgaggtg ggaggatcgc ttgagcccag 110580 gaattcaagg ctgcagtgag ctatgatcat gccactgcac tccagcctgg atgccagagt 110640 gagatgatgt ttccaaaaaa aaagaaaact gggctgacaa gaaataagaa aacaggctgg 110700 gtgcggtggc tcacacctgt aatcccagca ctctggtagg ccgaggttgg atcacttgaa 110760 gtcaggagtt cgaaaccagc ctggccaaca tggtgaagcc ccgtctctac taaaaataga 110820 aaaattagcc aggcgtggtg gcaggcgttt atagtcccag ctactcagga ggctgaggta 110880 ggagaatctc tttaacccgg gaggcagagg ttgcagtgag ccaagatcgt gctactgcac 110940 tccagcctgg gcaagagagc gagactccgt cacaaaaaaa aaaagaaaaa atacgaaaac 111000 agagaagaaa aacaccacca ccatgtctcc tgtgtttggg tcagcagagt agggactgaa 111060 tcccttcttt tctgtacacc tgaagggttt ttcttgcctc tgttcctgga ttctaaattg 111120 agtatgtttc tccaatgtct aacctaacgt gatttgaagg ggtttttttt ttcttgatag 111180 cggggtcctt tggtgtggtc ttggggctca agagtagggc tagtagggat tacagggtca 111240 gctctcccac cctcaggagg cccattttta atagacggtg aagttgaggc ccagtgcggt 111300 ggctcacacc tgtaatccca gcacaggagt ttgagaccag cctgggcagc atggtgaaac 111360 cccatctcta ttgaaaagaa aaaaaaaaat caatataaaa aacatttaca tgtcaaagta 111420 tataataaag tttatgagaa aaatagctgg tgatgttgag tgatgggctg atcccagggt 111480 cgccccagat gtgttgactg cccgtctctt ccaaggtggc ccacatgaag agcaaagaca 111540 atcggatcaa gctgatgaac gaaattctca atgggatcaa agtgctaaag ctttatgcct 111600 gggagctggc attcaaggac aaggtgctgg ccatcaggca ggaggagctg aaggtgctga 111660 agaagtctgc ctacctgtca gccgtgggca ccttcacctg ggtctgcacg ccctttctgg 111720 tgagtgaagc cacatttttc ctggccctca ttgtttgatg ttttattttc tctgcgtacc 111780 tgaatatttt taaaaggtca ctatgttgcc caggtgcagt ggctcatgct tggtaatccc 111840 agcactctgg gaggccaaag caggtggatc acctgaggtc aggagttcaa gaccagcctg 111900 gccaacatgg tgaaacccag tctctactaa aaatacaaaa aaataagccg ggtgtggtgg 111960 cgcatgcctg tagtcccagc tactagggag gctgaggcaa gagaattact tcaacctggg 112020 aggcgacggt tggagtgggc caagatcacg ccagtgcact ccagcctggg cgacagagca 112080 agaccttgtc tcaaaaacaa acaaaaaagt cactatgtca gcaaggcctt ccctgaacac 112140 ttggtttaaa catttgccat cttctccatt ctcctttgtt ttattcacac ttagcagctt 112200 ctagccaacc tgtgtaggaa ccgttcgtta tctatttact gtgatataag gagcttgtgc 112260 cagaatgtaa accagtgccc cctgcttcct gcattaagat agccttgcaa gacaaaaagt 112320 gcgagctgag tcgaacggca cgcttggtgc catagttgat ctacattgtg gtgctgcgtc 112380 cttattttgt caccaactgg tcacaaagtg tggattgtca gtgtctcata ggccacatgt 112440 caagtggcat ggtctaaaca cactctaaaa tttacttatt ttgggctggg tgcggtggct 112500 tgtgcctgta atcccagccc tttgggagtc caaggtgggt agatcacttg aggccaggag 112560 ctcgagacca gcctggccaa cctggtgaaa ccctgttact gcttaaaaaa aaaaaaaaaa 112620 aagaaagaaa aaaaaagctg ggcatggtgg tgcatgccta tattcccagc tactcaggag 112680 gccgagacat gagaatccct tgaacctggg aggctgaggt tgcagtgagc cgagatcgag 112740 ccacggcact ccagcctggg caacacagca agaccctgtc tcaaaaaagt aaaaaaaaaa 112800 aaaaataagt aaaataaaat gtacttattt tattgtctgc ttttccccca ctaggatgtc 112860 agctccagat gggcattttt gtcgtttctc ttgactgctg tatcctcagt atataaaaca 112920 gtgcatagca ggtgctgaac aaatattgtc atccattgta aaaaaaaaaa aatacagaaa 112980 gatataaaat gaaaagtata ttgtcctctc ttccatcagt tcctcccttc taaagtgaca 113040 gtttcgtgta cgcttttaga gaaaaatgga caagcatata ggtatttaaa aatactttga 113100 cagatataaa tggaatcata ctgtacatag tgttctcttt tctttggtta acaatatata 113160 gtcttggttc gttcattctg gtctacttca ttttagtttt ttggggggtt ttgttttgaa 113220 atggggtctc gctctgtccc ccaggctgga gtactgtggt gcgatcatag ctcactgcag 113280 ccttgaactc ctgggcccaa gcaatcctcc tgctttagtt tcctaagtag ctgggactcc 113340 aggtgcactg ctaccactcc cagcttgttt catttgtgtt catgatggat gcttgtctga 113400 cgtgcagatg cgccctgctg gaattaccct ttctcccatt ccttgcaaaa acaggttgtt 113460 ccctgttttt tttgctgtta tgatccatgc tacactgaaa gttctggtac ctgtcctggg 113520 gtatggtaat gggtctatcc ctgcctagct ggctttgaaa agtttaaaga caacagtgca 113580 acttacaatt tgcaaagttg gccgcaaatc aggagaccat acagagatgg actttggaaa 113640 ttcccttttt aagcacagtt aaaaacagtt aatggtgaag gatgacttca gatcatgccc 113700 catgtttgtt ttttctttct gtctttttat taactgtgtc attctttttg taatgttgtg 113760 ctcattacaa ctattccttc ttggtcaggt tggcaaatta tatgtttttc tggcaagttt 113820 ctgtgaagca gagttaaaca tgtttatgaa tatgaacttt tctgttaaac taccatctgc 113880 ttcatctttg ttgagtttca ggtggaatgt ctaaggaagc tccagctgtt tcagcatttg 113940 cgaaagcgtg ttcatgctcc cactgaattt tcttagtctt gccttacttc tctcagggtc 114000 tggaactgca ggagagatgg tgttcaaatt caagcctgca tcagaatcac ctggagagct 114060 tgttattata ttttattatt tattcattta ttgagatgaa gtcccagtct gtcacccagg 114120 ttggattgct atggcactat cttggctcac tgcaatctct gcctcccggg ttcaagcgat 114180 tcttccacct cagcctctga gtagctggga ttacaggcat gcagcaacca tgctcagcta 114240 atttttaaaa tatctttagt gtagagatgg tgtttcacca tgttggccag gctggtctcg 114300 aactcctgac ctcaggagat ctacccgcct tggcctccga aagtgctggg attacaggca 114360 tgagccacag tgctggctgt tagcttgtta ctataaaact cagctttctg ggccccaccc 114420 aaattttcag ttttagtagg tctggttggg gcctgagtat ttgctttcct aacatatccc 114480 taggtgctgc tgcttctggt tcaggttgac atgtagagac accggagtgg atcctcactg 114540 cctaaagtct ggtccgtgga ccagcagcca tggcatcacc tggtgcttgt taacggtgca 114600 gaatttcagg cctcagccca gatccactga aacggaatct gagttgtaac tagttctcta 114660 ggtggtgtgt atgcacatta aatttcgaga gagactggca gaaagtagga gtaaagaaac 114720 tttttctgta aatactttcg gaattccggg ccatacagtc tctgtcacaa ataccagtct 114780 cttccagcgt agtgcaaaaa cagccttaga taatatggaa atcgatgggt gtggctgtgt 114840 tcctgtaaaa aagtatttag agacaccaaa atttgaattt tatagaattt gcatgtgtca 114900 tgtaatattg ttttgatttt tttaactttt aaaaaatatg aaatctggct gggcgcaggg 114960 gctcatgcct gtaatctcag cactttggga ggccgaggcg ggcgggttgc ttgaggctag 115020 cagattgaga ccagcctagc caacgtggtg aaaccccgtc tatactaaaa atacaaaaat 115080 tagctggaag tggtggtgcg cacctgtggt catagctact cgggaggctg aggcaggagg 115140 atcgcttcaa cccaggaggc agaagttgca gtgagccaag atcatgccac acactcctgg 115200 ctgggcaaca gagtgagacc ctttcctgct gctgcccccc caccccctcc cagcccccca 115260 caaaaaaaaa ttagccaggt gtggtggagc atgctggtca tccaagcttt ttgggaggct 115320 gaggtacggg aatcgtttga acccgggagg cggagatcgc agcgagctga ggtcacgcca 115380 ctgcactcta agcctgggca acagaacaag actctgtctc aaaaaaaata aaaaaaatga 115440 aatcaatgct gagctcatgg gccgtatgta aacaggtgtg ggccaaatgt ggacctgagc 115500 catccttgtt ggccagcccc tggcttagag gactggaatg ttcttctgag aatcaggaca 115560 cctgccacat tctactgcca gctcacagtg tgaccccaaa gctggtcatc tcacctcgct 115620 ggctctagat tttgtcacat ggaaaatgaa ggggttagat tccaagcatg tcaaatactg 115680 ggccctgtcc tccttcctca tgcccacagc agacacccac agtcactcat ggggttcttt 115740 cccactgagt tatgttcaag cagccctcca ggtgactggt gccagtggcc tagagttgag 115800 caagaaatga catcttgttg cccttctgta actccatgtt ccctaagatc acttccagct 115860 ccaatgcccc tgcattctgc cttgtacatt gcattcttct tacactccaa taccttgact 115920 ttaccggggt gcgttgatga actctctctt tttttgtttt ttttgggact gagtctcact 115980 ctgtcaccca ggctgaagtg cagtggtgcc atctcagctc actgcaacct ccatctccca 116040 gttcaagcaa ttctcctgcc tcagtccccc gactagctgg gattacaaac atgcactacc 116100 atgccttgtt aattttaata tttttagtag agatgggttt ttgtcatgtt cgccaggctg 116160 gtctcgaact cctgacctca agtgatctac ctgccttgat ctcccaacgt gctgggatta 116220 caagcgtgag ccaccgcgcc tggactctcc tttttttttg agaaggagtc ttgctctctc 116280 gccaggctgg agtgcattgg cacgatctca gctcactgca atctctgcct cttgggttca 116340 agcgattctc ctgcctcagc ctcctgagta gctgggatta caggcgccta ctaccatgcc 116400 cagctaagtt ttgtattttt agtagagacg gggtttcacc agggttcaag caattctcct 116460 gcctcagcgt ccgagtagct gggagtacag gcgcacgcca ccatgccaag ccaatttttt 116520 gtatttttag tagagatggg gtttagccgt gttggccagg ctggtctcaa actcctggcc 116580 tctagtggtc cacccacctc ggcctcctaa agtgctggga ttacaggtgt gagccgccat 116640 gcccggtggg tcttacttta taaagtagga agtaatgtat ttgcatatgg tgaaacataa 116700 ttaaagctgc accagatggt attcatacag ccggacttcg cacgtggcca cctcagcctg 116760 ctgacattcg ccaacaggtc atcctttgtc cctgtgttgt agggcctgga ctgcacattg 116820 caggatgttt cccagcatct gtggcctcta cctgccagat gctaagtcgt acctctccct 116880 cttcttccca gtggtgacaa tagaaaatgg ctccaggcat tgcgaagtgt ccccttgggg 116940 gacagaattc tcccagttga gaaccacagt caatagtgaa aggcccaagc ccttcctcct 117000 aacaccagtc accttgcttc cctctctcca tgtttcttgt gtgtttttcc agagtccacg 117060 tctgtatcac tgtaatggtg gatacatgtc atacatgtag ttatggttac ttgattctgt 117120 ttactttact tttatacaag tgatagtaag agtcatacat aaatacatac aaaatggctt 117180 tttttttctt tttttctttt tttttttttt tttttgagat ggggtctcac actgccgccc 117240 aagctggagt gcagtgacat gatcttggct cactgcaacc tctgcctccc aggctcaagt 117300 aatcctccaa cctcagcctc ccaggcagct gggactacaa gcatgcacca ccatgcccag 117360 ctaatttctg taattttgca gagacagggt ctcactttgt tgcccaggat gttttcaaac 117420 tcctgagctc gagcagtccg cctgcctctg tctcccaaag tgctgggatt gtaggtatga 117480 gccactgcac ctggccttga tggcattttg aaaggtcttg tctcagagga aaagatacaa 117540 gccagagggc gctggtgatg aggtttggtc tgtgccttgt gtcccgctta ggaggggatg 117600 ggcagcgtgt tctcacagct ttttgctctg cacattggat tcgttggcaa aacccacagt 117660 ttccaggctg tcaccaaact ttgcttatca cttcctgccc tgttccccat taggaaacca 117720 cagcagaaga tgcttaagag caggactggc ttttcttctc ttttttcttt ctttctttct 117780 tttttaaaga gacagggtct tgttttgctg tccaggctgg agtacagtgg cttgatcaca 117840 gctcactgca acctccaact cctgagctaa agcgatcctc ctgcttcagc ctctggagta 117900 gctgggatta cagatgtgaa atactgagcc cggctaccgg ctttacttaa ccttttcttg 117960 agctttcttg ccatttagtt tcccggagtt tccagagaca gagtttgttg agctgtttgg 118020 caagaaacag atgggcctgg gtgtcagctg gggagacctt gtcctggccg aggcatcgaa 118080 gcctctgact acattaggat aaaatatgtg gcctttagtt cccctggaag gtgcctgagt 118140 gttttttcca ctggtgtgca ttcctgtgct tcaaagacga tgaggtgttt acccagcggt 118200 aggtgtgatg gaacacagag gccggggaag gccagggatg ccatccaggg actgatggga 118260 ctgtttttct ggaatggcaa acctggcatt taccacgtcc acctaatgca ctttcctaaa 118320 atagcatcgc caggcagccg tcaatattta acattttctg tcttggatga tttgtgagct 118380 tcttgccttc tgtttaccct gaatctccct ttgttagaat aattcatcat tctctatggt 118440 aatgatctgt cctgtagttc tctgctgatc atatcctagg gcccatggag acactgccac 118500 gaccatgtca ttttatttat ttatatattt atacatttct gtatttttga gacggagtct 118560 cattctgccg cccaggctgg agtgcagtgg cacaatcaca gctcactgca acctccacct 118620 cccaggttca gctgattctc ctgcctcagc ctcccgaaga gctgggatta caggtgtgcg 118680 ccaccacacc tggctaattt tttgtctttt tagtagagat ggggtttcac catgttggcc 118740 aggctggtct caaactcctg acctcaagtg atccgcccac ctcggcctcc caaagtgctg 118800 ggattgcagg tgtgagctac catgcccagt cagaccttgt cattttgtgc ttgtaccagc 118860 aaagcatagg gaccttggca aatagttcat gctctgtaaa tgtatgtagg taaatgaata 118920 aatacatgaa tgaatgagag gttgaaataa atcatattaa ttaggaactg tcttgcaaat 118980 aacagaaacc tagcttaaat caactagagt aagagaagag ggggattttt gagtcacaaa 119040 actaaaaagt ctagaaaaag acttttaagc atgaatgggg ttccaggcat ggctggatct 119100 aggagttccc aagataatgt tgggaataac aacgtctctg actctcagct ctgctttctt 119160 gatggtggtt tctttattag ctggtagttt cctgatcatc ctgtcacctc agcaacccct 119220 gtgaacagag agtcttactc ttttccccta atatttcctg caaagctatg ggattgagtc 119280 tcattggttg tggtcgatca catgcttctt cctgagccag tcactgaggc cagggagata 119340 ggatgcttgg gtcagccagg gctaggtcat gtctttcagg gcttggggcc aaggtagggg 119400 gtgagggagg aggttcatct gtggctgaag ctcataggtt gacactggga gaagttcagt 119460 tcccccagag aaaattgcat gttgccataa acagagtaat agatgccagg taggcaggaa 119520 gagcaggtaa ctgcacacag ggcatcagga tttttaggga gtgggctgga gtgtaggggt 119580 tccattcatt ggttttccac gtttctcaga aaaggcacct aggggacagg tgctcctcac 119640 tgtgtatgaa gggcttttgc accctagacc ctcgcctatt acaaggcgaa ctccagtctc 119700 ctgctgcctg gagccccagt cattgtgccc gtcctaccag cctcttcgga tttccaaaca 119760 ctgcctgcag ggaacctgtt aaagcctgtg cttccactag actgtgcgtc tcagggttgc 119820 caagcccacc tcagtcccca gcgcatgatg ggtgctcagt taccacctga ggggtggatg 119880 gctagatgac ctcctccttc tggagaagcc aggaccatgg acctgaaagg ggccgcatga 119940 tgttgtcctg tcccctctct gtgtgtgccc tgtgctgcca gcagccggca tcgattggta 120000 cttggctcac caagggggct ggtacgtttt ggtggtgaga tgcctgaggc ctggtttgct 120060 tcactgctga agagacacct gtgatgtgct cttctgccct caggcaaatt cacctacccc 120120 gtccccaccc atttatccac tcccacccat ccattatcta tccagcagac attcactgag 120180 caccatgatc tgggctctgt cctaggctct gacaatacag cagtgcatac tacaggtaat 120240 aatctccagt catggaacat tcatttttca cggagagaaa cagacaagga aaaataggca 120300 caataaataa atcctagtgc tagagaaagc catcctaagt gctatagaaa gaaaagagtc 120360 agatctttgg aataagggcg gcttgcagtt ttaagtaggg tggtccaagc tcactgagaa 120420 ggtgacactt gaggaaagac ttgatggagg taaagaggcc aaccagggag tagcaagagc 120480 atgtgcaaag gccctggggc attactgtgc ccattcatag gtgggataac catggaggct 120540 gaaacagtgg gagtgagggg agagtgacag atgacgccaa atgaggtaca gggaagggac 120600 tttacaaatc agctgggcct tgggatctga gtcagcactt tgacttctac actgaaaaat 120660 aggttgactt tggagaggta cttttttaaa aattacttgt ttagagatgg gggcctcact 120720 ctgttaccca ggctggtgcg ggggcacagt aatagctcac tgcagcctcg acctcctggg 120780 ctcaaatgat tctcctgcct cagcctccct agtagctagg actacaggtg catgccacta 120840 tgcttgactt atttattaat attattgttg ttttgagacg gagtcttgct ctgttgcaca 120900 cgctggggtg cagtggtgca atcttggctc actgcaacct ccacctcccg ggttaaagtg 120960 attctcctac ttcagcctcc ctagtagctg ggactacagg cacatgccac cacacccggc 121020 taatttttgt atttttagta gagacagggt tttgccctgt cagacaggct ggtcttgaac 121080 tcctgacttc aggagatcca cctgccttgg cctcccaaca tgctgggatt acaggcatga 121140 gccattgagc ccagccacct ggcttatttt ttaaaaaatt ttgtagagac acagccttgc 121200 ttttttgccc tggctctgct cgaacttctg gcctcaagtg atcctccctc ctcggccttg 121260 caaagcattt ggattacagg catgggctac catgccgatc gaaatgtatt tttttaacgg 121320 aggtataatt caccatttaa aagtgtgcaa ttcagtggtt tttttgtgtg atgtgtggtg 121380 gtgtgaaggt cacccagtgg gttttttgta taaatgataa tgacaatcac cactaattcc 121440 aggacgtttt cattacccca aaaggaagcc ctgtacctgt taccagttgc tccccaaatc 121500 ttccattcca ttccaggcaa ccagtaatct gctttctgtc tgtctctgtt tatctactgt 121560 ggacttttca tataaatgga atcaaacaac aggtggcctt ttctgactgt tttctttttt 121620 tttgagacga agtgtctccc ttgttgccca cctgaagcgc aatggcatga ccttgcctca 121680 ctacaacgtt tgcctcctag gttcaagcga ttctcctgcc tcagcctact gagtagctgg 121740 gattataggc atgcaccacc actcctggct aattgtgtat ttttagtaga gacggagttt 121800 ctccatgttg gtcaggctgg tctggaactc ccgacctcaa gtgatccgcc cgcctcagcc 121860 tcccgaagtg ctgggatttc aggtgtgagc caccccgcct ggccatctga ctggtttctt 121920 agcatgatgt tttcaaggtt tatccatgtt ttagcatgta taagaatttc actccttttt 121980 atggttgaga agtctatcat gtagatacat gtagaccctt tcgagtaaag aatatctctg 122040 ggctgggcat ggtggctcat acctgtaatc ccagcatttt gggaggccga ggcagacgga 122100 tcacttgagg ccaggagctc aagaccagcc tgaccaacat ggcgaaaccc catctctact 122160 aagaaaaata caaaaagatt agctgggcat ggtggtgggc gcctataatc ccagctactt 122220 ggagactgag gcatgagaat cgtttgacct tgggaggcag aggttgcggt gaactgcgat 122280 cgcaccactg cactccatct tgtgcaaaag aatgagactg tgtctcaaaa aaaaaaaaag 122340 tatctttagg taagatgcca gtgttgcgtt accgcttaga agatgggagc caggatgggt 122400 gcagtggctc atgtctgtaa tcccagcact ttaggtggcc gaggcaggca gatggcctga 122460 gcccaggtgt tcgagaacag cctaggaagc atagggagac cctgtctcta caaaaataaa 122520 aaaactagcc gggcatggtg gtatgcgcct gtagtcctag ctactcggga ggctgaggtg 122580 ggaggaatgc ttgagcccgg gaggtcgagg ctgtggtgag ccatgattgc accactgcac 122640 ccagggatca tgcgtccctg tcgtttcgag caccttgcct ccctcttgac atcggagcct 122700 ggaaaatttc tgtgccatgg ctcagcgtca tctgtcttgt taatgtcaga gccagaacac 122760 gaaccagctc tggcttcccg tgggaccggg ctctcgcttg tgtgaccacg ttaatagatt 122820 ccttggaaga atgatctaag gaatttggac caaatcttcc aacaagaaat aaaaacagct 122880 gccatctgtt gagttttact gtgcttgggc cctgtgcaaa taaacaccct acataagtgc 122940 caacagccct taaaagccta tcatgacttc cattttatag atgagaaaat aggggcttgc 123000 ctggagaggt gaaataactc aaccagggtc ccacagcgga aatatggcaa agtgtatggt 123060 ttttattttt aagctgtatg accttccagg aagtaacaat gaaatggcag tgctgagacc 123120 ctgaaaatac atgggccgat ggccagatgg cagggctatt tgggtaaagt gggagagaca 123180 gctcccttga atggtgagag ggaggagtca ggtggccccc tggatggaag atggtttcag 123240 gcagaggaaa cgtcaggggc aaaggcctgg cttggggatt gtgcttggtg cttttgagga 123300 atactaagaa tgcccctcta ggacatctct gagaaagttg atgggagagg ccggctcttt 123360 gggctcccgg tcgttgattt atccagttca ttcccagagt gtttagtgag cacctgccat 123420 gtgccagata ctgccccagg tttttccacg agctccagca gctggtcagt tgtggccacc 123480 tggggagggc ccaagcgcgt ctccagggcc tgtcactgct cctaggatga tgactctcac 123540 tcggggcaca gcagtcagca ctgggcgttc tgcttgcagg tggccttgtg cacatttgcc 123600 gtctacgtga ccattgacga gaacaacatc ctggatgccc agacagcctt cgtgtctttg 123660 gccttgttca acatcctccg gtttcccctg aacattctcc ccatggtcat cagcagcatc 123720 gtgcaggtac agggggaagc tggggcgact tccgagaggg ggccttgggg ttctaggcca 123780 cgaaagcatg gaagtgcccc cgagcgcagc ctctagatca cactcccggt cgggctccat 123840 gaggcccgga caaaggctgc catgctttcg tctggtcatg cctgaaagaa agaaaacaca 123900 tttgacttct tgacagagaa ctcgcacttg agtatatgaa tcaagtttaa tgcagcaggg 123960 ctttcccatg ctctggaaga atctttccga aatactctgt tctcttcagc ctgttcctcc 124020 gccattccta tccttttttt aaaaaacgta gctcttgtct gacttgattg attttacaac 124080 ccactgatag gtcttgacca cccacgcttt gagaaacccc aaccttacag ccgggcgcgg 124140 cggctcatgc ctgtattccc accattttgg gaggctgagg cgggtagatc acctgaggtc 124200 aagagttcga gaccagcctg gccaacatag tgcaacctca tctctactaa aaatacaaaa 124260 attagccagg tgtggtggcg ggtccctgta atcccagcta ctcggaaggc tgaggcagga 124320 gaattgcttg agcccaggag gaagaggttg cagtgagcca agatcgtgcc attgcattcc 124380 agtctgggtg acacagcaaa aactccgtct caaaattaaa aaaaaaaaaa agaaaaaccc 124440 caaccttacg gccgggcatg atggtacatg cctgtaatcc cagcactttg ggaggccaag 124500 gcaggtggat ctcttaagcc caggagtttg agactagcct gggcaatatg gtaaaaccct 124560 gtatgtaaaa aaaaataaaa taaaataaaa taaaaataaa taaataaata aataaataaa 124620 taaataaata aataaatatg tttgaaaatt agccaggcat ggtggtgtgc ccctgtactc 124680 ccagcgactc agaaggctgg ggtgggagga tcagctgagc ttgggaagtt gaggctgcag 124740 tgagtcatag tctcaccact acactccagc ctgggtgaag ggagtaagac cctgtttttt 124800 tttgtttttt gtttttattt tttagaaaca atgtagacca tgtagaatct ctaaaattcc 124860 tgccattgac tgtgtaagga ggggtggctt tctgttttgt cacacttggg cactactgga 124920 agctcctgtc acttttctgc actgttttca cattcttttt ccgagcattg cgaacatccc 124980 ttttgaaaac tccattttaa ctacataggc aaatcaaccg taaaatttgg tagtacaagg 125040 ctgatagcag gctttgtcaa aaacaaaaaa atccatttta ttatgaaaaa tgtcaagtgt 125100 acacagaagt agaatagctt aaagtttgta aactggcatt aaaagaaaaa gaaaaagaaa 125160 aaaaaagcca agcatgatgg ctcacacctg caatcccagc attttgggag accaaggcag 125220 acagatcagc tgaggtcagg agttcgagac cagcctggcc aacatgggga aaccttgtct 125280 ctactaaaaa tacaaaaatt agccagatgt attggttggt gcctgtaatc ccagctaatc 125340 tggaggctga gacacgagaa tcgcttgaac ctgggaggtg gaggttgccg aggttgcagt 125400 gagccgagat tgtgccactg cactccagcc tgggcgactg agtgagactc agtctccaag 125460 aaaggaaata atacaacatg aaccccgtgt acacatcact cagattcaac atcggcattt 125520 tttggctggg cgcagtggct cacgcctgta atcccagcac tgtgggaggc tgaggtggta 125580 ggattgcttc agcccaggag ttcaaaatca gcctgggcaa tgagaccctt aatctacaaa 125640 aaataacaaa atgggtgtgg ggtgcatgcc tgcagtgact acatgggagg ctgaggcaga 125700 aggatcgctt gagcctagga gtttgaggct gcagtgagtt atgtttgcac cactgcactc 125760 cagcctgggc aacagagcaa gactctgtct caaataaaga aaccaaggtt gggcgcagtg 125820 gctcatgcct gtaatcccag cactctggga ggccgaggtg ggcggatcat gaggtcagga 125880 gatggagacc atcctggcta acacggtgaa accctgtctc tgctaaaaat ataaaaaaat 125940 tagccaggtg tggtggcagg tgcctgtagt cccagctact cggttggctg aggcaggaga 126000 atgttgtgaa cccgggaggt ggagcttgca gtgagccgag attgcgccac tgcactccag 126060 cctgggtgac agagcgagac tccatctcaa aaacgaacaa aaaaacccaa aacattttgc 126120 cacagttgat ttatctcatt ctttttcagt atccctccct tgtccctctt tcccttcatt 126180 tgtttttaat gctaaactct gctatctatc ccttcattct ttcctttctt tgccgaataa 126240 ttttaaagca aatctcagac cccttacatt ctacccacaa atatttcagc atgcatttct 126300 tcctacataa tgtaatacca tcatcatgtc taagcaaact aacaataagt ttttacaata 126360 atactcagcc catatccaag ttttctggaa tatctcagaa atgcctgtcc cattgggctg 126420 tttgaattgg ctctgttgca tttgctgtta cgtttccaga gtcccttttc caccaggcct 126480 ctgccctttt cttcttttat ttttattttt atttatttat tttttgaaat ggagcctcac 126540 tctgtcaccc aggctggagt gcagtggcat gatcttggct cactgcgacc tctgccttcc 126600 caggttcaag tgattcttct gcctcagcct cccgagtagc tgggattgca ggtgcgtgcc 126660 accatgccag gctaatttta tgtatttttt tttttttttt tagctgaggc ggggtttcac 126720 catgttggcc aggctggtct caaactcctg acctcaagtg atctgcctgc cttggcctcc 126780 caaagtgctg ggattacagg tttgagctac cgtgcccagc cattcgccca ttttttctga 126840 aatacctttt gtgggctttt aaaacaaagc agaaccaaac ctgtttcttt ttttgttttg 126900 tttaattcta aagtatacac tggttctaag aaatgtggga ccttcagaaa taagggaggg 126960 tgtgtgcccc tccacacctg gggaaaccct tgaaagttaa ccttggttgg ttttgcaaaa 127020 atgcttttta aaaataactc tcccctgcca ttgctctctg tacaggcgag tgtctccctc 127080 aaacgcctga ggatctttct ctcccatgag gagctggaac ctgacagcat cgagcgacgg 127140 cctgtcaaag acggtgtgtg tgtgttcagt cctggcttct ggaagtggcc gccttcccat 127200 ctcccactgg gtcctcccta cttgcatttc tttcccttgg ctgccctcag gtttgactct 127260 gcccagccgc ttgtctgcga gaccccgggg gacaagggtt ctgcagagcc tgcagaaggg 127320 aagggaagcc tggcctcctg ggcttctgtc ctgtctcaca cttcccagga gggtgaactt 127380 gcacttgcat ttttgttttc ttgctgaggg tcagcagctg cttgaggctt ccccgtggga 127440 gtcactttcc aaggctttga ccttgattct attctgggct aaatgaggac tctggaggct 127500 ggccagcctc catcacccac aagctgtgta gacttaggtc tgagcctcag ttttatctag 127560 ataagggaaa caaaagtacc tttctttggc tgagtgttac ttggattttt tttttttttt 127620 gagacagggt ctcattccat ttcccaggct ggagtgcagt ggtgcagtca cagctgtcac 127680 tgcagccttg atttcgtggg ctcaggtgat cctctgacct tagcctccca agtagctaga 127740 actacaggca cacacagcac catacttgga taatattttg gtatgttttg tagagacagg 127800 gtttcaccat gttgtccagg ccggtctcga actccttagc tcaagcaatc cacctgcctc 127860 agcctcccaa agtgctgggc ttataggcat gagccagttc tcctggcctt tttttttttt 127920 tcaatattaa attgttttat ttggagagac aaggtcttgc tttgttcctc aagttggtct 127980 tgagctcctg ggctcaagga tccctctgcc tcagcctccc aaagtgctgg gatgacagat 128040 gtgagccact gcacctggcc atgcattttt attggcaggt ttgtttgttt tgtagcttgt 128100 taatttatcg tttcccagcc catccccctg agccagggat gttgtttgta accatctctc 128160 taggcactta ataataaata ttaggccggg cacagtggct cacgcctgta atcccagcac 128220 tttggggagc tgaggcaggt ggatcacttg aggtcaggag ttcgagatca gcctggccaa 128280 caaggtgaaa ccccgtctct actgaaaata caaaaattag ctggacatgg tgttgggcac 128340 ctgtaatccc aactactcgg gaggctgagg caggagaatc acttgaaccc aggaggcgga 128400 ggttgcagtg agccaagatc gcgccactgc actccagcca gggcaaagag tgagacttca 128460 tctcaaaaaa aaaaaaaaaa ataataataa taaatattaa tggcactaag tgcagtgaca 128520 cgttcactta taaagcctct gtcatgcaca tgccattcca aggatgtcaa tgtcccaact 128580 tgtccattac tcaccatggt acccctggag gagggtgatg gaaaccccca ttttccagat 128640 gaagaaactg gtctctgaaa cttgcctgag attgcacagc tgatcaaaag aagaaccagc 128700 attcacaccc acagcccatc ggtagagtcc atgctcttcc tggccatagg gtgttgcctc 128760 actgagattt actgagcacc tactatgtgc caagcattgt gagaagtgct ctgtgtgcac 128820 tgcctcatag acaccccatc acagccctct gaagttgatt gcatgattgt cagccttatt 128880 ttacagatga aaaagtgagg cacaggctgg gtgcagtggc tcctacctat aatcctagta 128940 ctttgggagg ccaaggctgg aggattgctt gaggccagga gtttgagacc accttgggta 129000 atgtagtgag acctcgtctc tacaaaaatt aaattcacca ggcatggtgg tgcacctgta 129060 gtcctagtta cttgagaggc tgaggcagga ggattggctg agcccgggag ttcaaggcta 129120 tagtgagcta tgatcatgcc actgtactcc agcctgggtg tcagagtgag accctgtctc 129180 aaaaaacaaa caaacaaagg cacagagaag ttaactaact tgcctgtggc tacccaggta 129240 cgaagtggta gccccaggat tcaaacccat acagtctggc tccagagtcc aatgtcagaa 129300 gattgaatgt gtgtaaacgt cggttatacc gcgtgagctg tgtctggcac ctcgcaggcg 129360 ctcaggtatc tttagtggca cctaaaacgt ttgacacgtt tgacacagca cctggtgcat 129420 agaagatgat aaacagatcc tgggagttgt cacttctctg gtctgagcga gatggtctca 129480 gcatcttcag ctcagccccc tggtgtgggg ttttttatcc tgggcgctac tgacatctgg 129540 agacacattg ttctttgtgg ttggggactg tcctgtgcac tgtgggatgt tgagcagcaa 129600 ccctggactc tacccattag atacagtagt atccatccca attttggcaa ccaaaaatgg 129660 ctccagacat tgccagatgt gccttgaggg acacagttac ctccagttga gaaccgtggc 129720 ccaagtggat gctggactct tcctcccaac actcctgggc tgtggtcatc tggtttctgc 129780 tgtcccagtg tcccacatcc cctcacatca taaggcaatg attccatcta ctctggggtc 129840 aaatttctct gctaaccaca ggctgaaatt tgaggtggcc ggcggtgggt ggggggtggt 129900 ttcttggtac tgaagttgtt cacagctcaa tgcaagcatc aggaaacccc taggcccctg 129960 ggtgccgccc gcaccccagc ccctccttcc tgccctaata gtggcctcct aggtggttgg 130020 acttcctgga atgtttagca cgctctagcc agtgggggcc cccttggctg ctcccagctc 130080 ccaagctaac cgttctctgc aacctctctg tctccagtgg cttttcttaa attccttaaa 130140 tagcaactcc cagtttcctc attccacgtc cactcgtaga agagctgagg gagaaagtta 130200 atctaggtta accagcacct tcctctctct ctaggttttt tgtttttttg atgcatggag 130260 gaagttattt cttcatttga caacttaaac aaaaaatact cctgtattat ctccagatgg 130320 tcttaaggtg gctcataatt cagagagctg cttttctgtt ttttcttttt cttttttttt 130380 ttttttttga gacagagttt cactctgttg cccaggctgg agtgcaatgg cacgatcttg 130440 gctctctgcg acctctgcct tggtttcaag cgattctcat gtctcagact cccgagtagc 130500 tgggactaca ggcatgcgct accacacctg gctaatgttt gtatttttag tagagatggg 130560 gtttcaccac gttggccagg ctggtctcga actcctgaca tcaggtgatc tgcccgcctc 130620 ggtctcccga agtgttggga ttacaggcat gagcccctgc gactggcctg cttttgtttt 130680 aagtgagaga catgaagtaa aaggaaaata acaggaagaa gagtaaaaga agacagaggt 130740 gctaggagct ttagaagtgt ggagctggcc gggcatggtg tctcatgcct gtaatcccgg 130800 cactttggaa ggccgaggca agcagatcac ttgaggccaa gagttcgaga ccaggctgag 130860 caacatgtca agaccccacc tctacaaaaa atacaaaaaa aaaattagct gggtgtgatg 130920 gtgcacatcc tgtagtccca gttgctcagg aggctgaagt gggagaatcg cctgcgcctg 130980 ggagatggag gttgcagtag gccgagatcg caccactgcg ctccagcctg ggtgcagaag 131040 ccagatcctg tctcaggaga agacagaaac atggaaccag ttaacgtggg ctttgtctcc 131100 gacactctcc ccttccctgt gccctcgtac cacacttcct gttccgtatc ctcttttttt 131160 gagtttatcg tgatggatgt tttagaaaga tccacctgct gtgatgtgct gtgtgtagag 131220 tggtgtggct gggggaggaa gacagaggac ctggggagaa gggtgaacga cctccctttg 131280 cacctcaagg agggcccagc ggtctgatgc tggccacccc agtggagaga ggtttgcatg 131340 tggacgccag ctgtttccca ctgaccttgg ccactgctcg gccctcccag ctggagctgc 131400 cccgaacctg cctgagaagg gccagggcat cgagagcatt gagtaattct catgcggccc 131460 ccgcctctgc agtcatctcc caagatgatc gtccagatgg cgcaacccca tcttacaagg 131520 acaaagctgc ttgcagtttc cttctgcttt ctgggtctgg ggctgcctcc agaactgcag 131580 gttgagtttc ttctttcaga acccgtggct gatgtcacca gataataatg cctagcgcca 131640 ttcgtgccaa gcgtctgggg ttgaaccatt caagcagaga aagagagtgt tctgtgcatg 131700 tggagtcgca cagctcagcc tgtccctgac atgtctctgt gctttgtagg cgggggcacg 131760 aacagcatca ccgtgaggaa tgccacattc acctgggcca ggagcgaccc tcccacactg 131820 aatgggtaag ccgggacgtg gacacacgtg atggtgtgga gagagccaca gggcttttgt 131880 taaacgtgga ttcgaattcc caccgtgctc cctctctgtg accttgaaca actcactttg 131940 cctttctaag acttagctta cccatctgga caatgggtgc agatacacct gcttaggctg 132000 tcgtgagaag cagacacaca tgcctagcac agagggttcc ctgggattgt aagttacagc 132060 agccttggac agctagactt agacaataca ggagattctt ggcttgcgta actgggaagt 132120 tctactttca ggtgcggtgt gatccaggga ctctgccgtc agaactttct tcatattttc 132180 tgtgtttcac tttctcctgg tctgctttat cctcacgcat cctctcccct tgtgatggta 132240 aatggtccca acagctccca ctgtgtatcc cactgttagg agaactgcct gcttcttatt 132300 gacccagatt gggtcctgtg ccctctgtga ggcaatcgct atgccttcag acactgagtg 132360 tgctgattgg ccagtctcag tcaggggctg tgatgctgct gaactccagt gcccctcagc 132420 tgcccagctc accctttctt gccagctttc tatctggcac cccacaccct acagtcctta 132480 cctttccaaa gcacatgatg tctaggaaat tgaccttatc cccaggcaac ttgtcaagca 132540 cctctcattt tgttctgacc agaggccttg atcaacagct ttttaggccc ccttaaggaa 132600 tccgcaaaac acaggggtga tgggaccctt ttagaggttt agctcatgcc tgggtagcca 132660 aatcactgct gtattttatg atgaaggaga gaaactctcc agagaaaaca atctgtagaa 132720 ggcctgcatt gaaaattcat gggggtactg catgcttagg aagttcttcc ttatgtctaa 132780 cttaaatcct gcctgcttca attgtagctg ttctgtcttg ttgagctgca caactaatct 132840 gtatctgtgt ccctttcctg acccagtggt tttcctgttc agttaccttc cccccatgag 132900 cccccagaac ctttctctaa cccttttctc tcatcagcct gtaagaatat ttcagtctca 132960 cgtggacagt ggcaggtact gtctcacgtg gacagtggca ggtattgtct cactgggctt 133020 cctgcccact caggccccat aatcctttcc cctcccagca caggaacaaa aagcctgatg 133080 agtgtcacca tgcagcagtg tcataagaat gaaacaatca gtgacagcaa cgactatcag 133140 catttccact aatactctga aatcagaaag gtggcagtta aaaagcacag aatcccagca 133200 ctttgggagg ccaaggtggg cacatcacct gaagtccgaa gtctgagacc agcttggcca 133260 acatggtgaa accctgtcac tactaaaaat aaaaaaacta gctgggcatg gtggtgcatg 133320 cctgtaatcc cagcactttg ggaggctgag gcgggcagat cactggaggt cagcagttcg 133380 agaccagcct ggccaatgtg gggaaacccc atctgtacta aaaatacaaa aattagctgg 133440 atgtggtggc gctcgcctgt aatcccagct acttgggagg ctgaggcaca agaatcattt 133500 gaacctggga ggcacaggtt tcagtgagcc aagattgagc cactgtactc cagcctgggc 133560 cacagagtga gactcttgtc tcaaaaaaat aaataaatac ttaagtaact aaatacagat 133620 aaataaaaaa taaaagcaca ttccatataa gtgagtccag caaaggtttg gatgtgccct 133680 cccttccctg ggaggatgga aaccctgctc tggaggtgcc gtcggcagtg ggagtggcct 133740 ggggttgacc tgccccattg acagccggtc ttactgggtg aatgctgagc ttattttatt 133800 ttgctttctg ctgttcgtta aaggatgatt tcaatagaga catcttcctg aaattcaact 133860 cagatttatt catatgcgtt tcccttttca accctttggt ggctcccggc tggcagagtt 133920 caggtgtctt agcacagcgt ccttccaggg catatttcaa ggtgctccca ggtctggcca 133980 ctacctacct cagtgccatc gcatccctgg ttacaccctg tgccttcacc cctttacacc 134040 tttctccggc tctccacatg tttctgtgtg tgggacactc ctgctttttg tcagagtttt 134100 ttggtttatt tattttctga gacagagtct cacgctcttg cccagatcgg agtgcagtgg 134160 cacgatctca gctcactgta acctccgcct cttgggttca agtgattctt gtgcctcagc 134220 ctcctcagta gctgggacca caggccctgc caccaccacg cctggctaat ttttatattt 134280 ttagtagaaa cggggtttca ccatgttggc cagactggtc tcgagctcct gacctcgtga 134340 tccgcctgcg ttggcctccc aaagtgctgg gattaccagc actggcatga gctaccgtgt 134400 ccggccccag tttgtcttga ggtgtcctct cctttcagac cttgcgtcat gcccccagta 134460 aagtttctgc ctctccgagg ggcaaaaact gttccagaag cccactgtga caggatccct 134520 caggttactc cctgcctcac ttctctaagg gacacctgtc acctgcctcc cacctggagg 134580 ccccctgaga caggtcactg aactgaactc agcagtagaa atggaaggaa tgttgaggcc 134640 ttcagtgttt agtacagtct tgccttctgt ctttctcttt ctctacttgg ggtaaattga 134700 ggctcggtgg ccatgggcat tagcccggca ggcctcattc agcgtggctg agccaggtgt 134760 gttgtgtcgt ttcagcatca ccttctccat ccccgaaggt gctttggtgg ccgtggtggg 134820 ccaggtgggc tgcggaaagt cgtccctgct ctcagccctc ttggctgaga tggacaaagt 134880 ggaggggcac gtggctatca aggtaggatg aggaccagcg gggaggggca gtggggaagc 134940 tggtggtctg aggaaaagct cagaaatgat ggtgtttctt ttgactgtcc ctgtgccaga 135000 agcgaaagca gcaacgtctc ttttcctcct cctcctgtat ctttccactg tctctttctc 135060 tctcgttctt tctgttctgt tccgtgctgt cctagaaggc aggattttgg tatcatttat 135120 ttccatctgt ctcccagcac ttaaaatagt gcccagtata tagtaggcac ttaataaata 135180 tttattttgt tacctcttta ttaagctgtt attttattat tattattatc attattattg 135240 tgtttttttt tttttgagac agggtcaggc tctgtcccgc aggctggagt gaagtggcgt 135300 gatctcggct cactgcagcc tctgcctcct gggtccaagc gattctccct cagcctcccg 135360 agtagctagg attacaggca tgcgccacca tgtccagcta atttttatat ttttttagta 135420 gagacggtgt tttaccatgt tggccaggct ggtctcaaac tcctgacctc aagtgatctg 135480 cacacctctg tctcccaaag tgctgggatt gcaggtgtga gccaccgcat ttggccactt 135540 aagaaatact tagtagacac acgaagactc cctggtacgc agcctgtgtc tccttccctt 135600 gcgtctctgc ctgtcactga gtgtctcttg gtctgtttgg gtctttttgg attgttcttt 135660 atctttatgg atctctgagt atctattctt ataaatgtaa caaaacaaaa atgtttatgt 135720 ggttggaata ttttcttaga acatttttta aagggaacag tttaaatttt tagtgttgaa 135780 ttcttaatat ggagctaaaa gaagactgca gttttactgc ttttaaatac acagtgtact 135840 ttgaagtaag ttgaaattcc ccaggagtga gcttaagagg ctcctttaca aataatcccc 135900 actggaaatc aacagccttt gtttgcattt agttcactcc ccatgaaggc cttttcctag 135960 tgtaacgaca cgtccctgga agttttgcta ccagcatttc caggagtgtg gtctgcagcc 136020 agctcatctt gcaggacatt tgggcgataa agaaccccag gctcaaagaa gcgtgggaaa 136080 taatgcatac tccagccccc tccctcttgg agacttacag taaacattag caaattaaag 136140 gctctgacaa gtcctgcaag gagaaaaaat ctattaactg tttaacctta tgtgtcccag 136200 gtgtacttgt ccgcacctct ttagtgtctg tgcaactgca catttgtctc ttggaatctg 136260 cctttgggaa tgtcaagttt atgacgttgt ttgttgttgt gggttttgag acagagtttt 136320 ttttgttgcc caggctggag tgcagtcgtg tgatcttgac tcactgcaac ctctgcctcc 136380 tgggttcaac cgattcttct gtctcagcct cttgagtagc tgggattata ggcacccacc 136440 attactgcac ccggctaatt tttgtatttt cagtaaagac gggattttac catgttgacc 136500 tgggtagtct agaactccta acctcaggtg atctccccat ctcggcttcc caaagtgctg 136560 ggattacagg cgtgagccac cgctcctggc ctagttaatg acattgtttt tatttcagag 136620 caaaaccctt tctttgatta tacagtgcct ttagaaagta tacattgtgg ttgggtccaa 136680 attaatgacc tttagctgtt gttttaagaa atgttttatc attactttca agttcctgcc 136740 ataaaataag atgaatgaac catgagagct agattaatgg aagaaaattc caaatcccga 136800 tgggatccac attgctttct gtttccttaa ccccagcttt ctgctatcct ggcactatta 136860 gcatttcagg ccagatgatt atttattatt ggttgtttgg cctaggtaag gggagtgcta 136920 gaaatgtata taaaatattt atcttttccc aaatgtttta gttggtgtgg tttgtgtata 136980 ttatgtctga aatttctgtg ggttctatgg taaggcacca ctgttgacat tttggctttt 137040 taaaagttag gatattcaag tcagcaggtt aattatttga gaatttagag taagaatgag 137100 ggtacctggg acctgctgtc agctttgccc tctctagaat tcccttattc aagaatcttc 137160 tggctgggcg cggtggctca catctgtaat cccagcactt tgggaggctg aggcaggttg 137220 atcacctgag gtcaggagtt tgagaccagc ctgaccagca tggcgaaacc ccgtctctac 137280 tgaaaataca aaaattagtg ggcctggtgg tgtgtgcctt tagtcccagc tactcaggag 137340 gctgaggaag gagaatccct tgagcccgga ggcagagact gcagtgagct gagatcttga 137400 cactgtattc cagcctgagc gacagcaagg cttcgtttca aaaaaaaatc ttcaggggct 137460 ccccttgccc ctctgataaa gcccatgctc cccaccaagt ataggccccc ttgctgtccc 137520 tggtgtgttt tctgccagtc gttccctcac aggattgatc gatgttcctg tcacgctggc 137580 ctttctgttc cttgaatgtg ccaagtactt ttcacttcca ggccttcgca tgtgctgttc 137640 cctcggactt gaatgctctt ccctcttctc ctcatgaaac tgactcattc ttcacttttt 137700 ggttcttgtc taaacatatg tttgagctga gcatgatggc tcatgcctat aatcccagca 137760 cttcaggagg ccaaggcagg aggattgctt gaggccagga gtttgagacc aggcttagca 137820 acatggcaag attttgtttc tacaaacgta ataaatatat agagaattaa ctacctcagc 137880 attttcatta gcaaaataca caaaacaaat atccttactc tagcctttat tctcatgctg 137940 tttgtgatac ctgacatatg gaaataaaaa taagcctttg aaatggatgc ttgatatagg 138000 agtctttgct tcaattttta gcaaggatat ttcctcaaag atccttcccg gatgtcccaa 138060 actaggtcag tcttttaatt tttttgagac aggatcttgc tctgtggtcc aggctggagt 138120 gcagtggcac ggtgcaatct cagctcgtgg tacctccatt tcctgggctc aggtgatcct 138180 cccacctcag cctcccaagt agctgggact acagatgcac agcgccatgc ctggctaatt 138240 tttctatttt ttttagagat gggatttctc tatgttgtcc aggctggctt tgaactcctg 138300 acctcaagca gtctgcctgc cttggcctcc caaagtgctg ggattacagg catgagccac 138360 tgcgcctagt caagttagac tcttaaaaag tgtcatatat ctttttatct ttgcgtccac 138420 cgtaactgta atcaagtagt tttccgtcac ctgagggact tccactcttt ggaagcaggg 138480 gttttgatca ccgctgtagg cattgagtta atagctagct actaagtaaa taactgtaat 138540 cttatcaacg aggatatcaa ctctttgact cctgatattg gagtcagtga ttcacctgct 138600 gtgggttctg atcccagccc tggcatctgt tgtcctttgt gagtcagttt ccctcttgcc 138660 aaagcaatag ttgtgatgaa aatgacttgt gaagtgaggc cctcctagca ggcgggtggg 138720 ccagctgttg tctcgttgat cagatctgtc tgtgtgtctg tctcacctcg ttctccattt 138780 gcaacttagg gctccgtggc ctatgtgcca cagcaggcct ggattcagaa tgattctctc 138840 cgagaaaaca tcctttttgg atgtcagctg gaggaaccat attacaggtc cgtgatacag 138900 gcctgtgccc tcctcccaga cctggaaatc ctgcccagtg gggatcggac agagattggc 138960 gagaaggtca gtataggttg gatgttggcc cctgaatcag tcagctgttg ccgcgtaaca 139020 aatgctctca caatctcagt gggctgtgag tctgctgcta tcagctgacc cggcagggct 139080 cagctgggcg gctctgctgc acgctgcagg ccagctgaac ttgggtccag gctgtgggtg 139140 tggctcaggt ctcacttaca gagcttttgc tggggaccgg ggtgaggggt ccacagcttt 139200 ccaaaggggg gctcttctca tggtggcagc agaggcccaa gataggcccc ccagaaagca 139260 tgcaatgtcc cttaaagtac actgtccctt ctactcacaa agcaagtcac ttggccaagc 139320 tcaaaggcaa gggaccaaga aggaagtaca ttctaccttt gtggtcacat gactgcagag 139380 tcacatgaca gagggcatgc tgttgggagg aggggagtcg atgattcata tgttcacagt 139440 ccctgtcaag atagccataa tactgaaaat agcacaatag ctaacactta ctgagcattt 139500 tctctttctt ttctttcttt ctttttattt atttatttat ttttgagatg gagtcttgct 139560 ctcttgccca ggctggagtg cagtggcacg atctcagctc actgcaacct ctgcctcccg 139620 cgttcaggtg attctcctgc ctcagcttcc tgaggggctg gaattacagg tgcatatcac 139680 cacactcggc taatttttgt atttttagtc gaggcagggt ttcaccatgt tggccaggtt 139740 ggtgtctaac tcctgacctc aagtgatccg ctggcctcag cctctcaaag ttcttttttt 139800 tttttgaaat ggagtctctc tctgtcgccc aggctagagt gtagtggctc actcttggct 139860 cattgcaacc tctgcctcct gagttcaagt gattctcctc cctcagcctc ttgaatagct 139920 gggactacag gcccctgcca ccacgcacag ctaatttttg tatttttatt cgaggcaggg 139980 tttcaccatg ttggccaggt tggtgtctaa ctcctgacct caagtgatcg gctggcctca 140040 gcctctcaaa gttctttttt tttttttgaa atggagtctc tctctgtcgc ccaggctaga 140100 gtgtagtggc tcactcttgg ttcaacctct gcctcctgag ttcaagtgat tctcctccct 140160 cagcctcttg aatagctggg actacaggcc cctgccacca cgcacagcta atttctgtat 140220 ttttagtaga gatgggattt cgctgtgttg gccatgctga tcttgaactc ctggcctcag 140280 gtgatctgcc cgcctctgcc tctcacaatg ctgggattac agatgttaac cacctcgccc 140340 ggcctataac ttgagtattt tctgtatgtt gggaactatg ctaaacattt tacacgtaat 140400 tcttccccac agcaagccca tgggtggaat ttgttgttat acctaggtaa tcattgagga 140460 aaaaggaggc acagagaggc caagtgactt acctgaggcc acacagccac agagctgcag 140520 agagcatggt tcctgtgtcc atgttgttac ctgctcattt tgtcatctct aaaagggcca 140580 ttctctgcct ctcaccactg cagaccctcc ctcctgctgt gctccatctc ccaggttttc 140640 ctgctgcttc acagcaaccc ccagcccctg cccacctcca caccttggtc tgagccttca 140700 aggcctgggg tgcctcccct gctgcttgcc tggccacttt gctctggcac cccatggtgg 140760 tcgtctggtg tgtcccctct tggaagacca agagtgcaaa gcactggccc atttctgttt 140820 ttagttacaa gccaggggct ctgtcggctt tcttacgtgg tgaatgatgt ttaaaaattg 140880 agataagcct gcagctcctt ggaaataaaa aacgaattat tggctgggcg cggtagctca 140940 cgcctataat cccagcactt tgggagacca aggtgggagg attgtctgag gtcaggagtt 141000 cgagaccagc ctgggcaaca tggtgaaaac ccacctctac taaaaataca aaaagttgcc 141060 aggcatggtg ccgtgcacct gtggtcccag ccacttaggg ggctgaggtg agaggattgc 141120 ttgaacctgg gaagcggaga ttacagtgag ctgagattgt gccactgcac tccagcctgg 141180 gcgacagagt gagattctgt ctccaaaaac aaaaagaagg cacgtggctg ccaggacccc 141240 acctcagtgc atgggagtca gggcaggcat ctcaggaggg actgggcagt aacctgtgat 141300 ttccagccaa atagggaaac gacgttggct tatctgtcat ggtgggagct ggcgctgctg 141360 ctggtccatg cattgtcctt cctcctggtg actgggatgt gggctggatt tcagcatccc 141420 caggccggag ccttgcttca cctatatgtg gctttgccag acagtgacag atccagagta 141480 agctggcaaa catggcagct gtcaccaaca gcagcagtaa caataatatg accacgtcca 141540 ccagcgcctt ccatgagact aagggatcac ggccttccca ctggtcaaca tgatttggtg 141600 ccgtcagcca tcctttgctg agcacttgct gtgcaccacg tgccctgctc agcacctcac 141660 gggagattca ggttttctct tttgcccagt tgacaggtgg ggctaaaccc tgtgcctgtg 141720 atcccatcct tggtggtggt ggagctgggg cctggctcca ggtttgtgca ggcgtgacct 141780 catgccttca gcatcaaact taaagaagag gaggtgggtg cagctctgca gggccttcac 141840 ccaggacctg ctgtgtcctg agcaggctct atgcctttct ttctttcttg tttaaagaga 141900 cagggtctca ttctgtcgcc caggctggag tgcagtggcc cagccatagc tcgttgcagc 141960 ctggaactcc tgggctcaag ccatcttccc actcagcctc ctgaatagct ggaactacag 142020 gcgcacatca gcaggcttgg ctaatttttt cttttctttt cttttctttt tttgtagaga 142080 cagggtctcc ctatattgct caggctggtc tcaaacccct ggtctcaagc agtccttcca 142140 ccttggcctc ccaaagttct gggatcacac cacactcggc ctgcttctac gtattgtgag 142200 tctcaagatt tcccaggaaa cccactcctg tgtgtgtctc tccccagggc gtgaacctgt 142260 ctgggggcca gaagcagcgc gtgagcctgg cccgggccgt gtactccaac gctgacattt 142320 acctcttcga tgatcccctc tcagcagtgg atgcccatgt gggaaaacac atctttgaaa 142380 atgtgattgg ccccaagggg atgctgaaga acaaggtgcc tgctggcggg gtggggcttg 142440 gtgttgggcc gtctcgccct ttggttaagt cagaacgtgt cccctttagg agtcctttac 142500 tttctctggc tttctttgtt tttaattgga ctttaaagaa cacatttctc atgcttgtct 142560 tggaagcctt cctaagacag ccgtcttgta cttgtcttta taggggtaag tcctccgcgc 142620 agagttaaat tcattgcctc tccatggcca agggaggcct ctcttcctga ttaagtcaca 142680 gggctggctt cttagcgggg aatcccactc caagacattg cctgtgacct agcaggctgc 142740 attttcttac ttgcagaggt gtctgtgggt agaggggtcg gaaaattgcc acaacacctt 142800 aacataatag gaaatagttc ctgtgttctt tttatagggc agttgtggta atgggtacac 142860 actggctctt ttttttctcc ccctgatttt atttttttga ggtggagttt cgctactgtt 142920 gcccaggctg gagtgcagtg gcatgatctc agctcactgc aacctccgca tctcgggttc 142980 aagcacttct cctgctttgg cctcccaagt agctgggatt acaggtgccc accaccacgc 143040 ctggctaatt ttttttattt ttagtagaat cgaggtttca ccatgttggt caggctggtc 143100 tcgaactcct gacctcaagt gatctgcccg cctgggtctc ctgcaatgct gggattacag 143160 gcgtgagcca ccacacccgg ctgtttctgc tgattttaaa actaacacat ccccatgggg 143220 ggcatataga ttaagaaaaa catgaaaaag aaaaatggaa gcagttacac acattccact 143280 ggttagaggt tttgtatttt tttcaagtct ttttgctctg tgtataaact ttttaaatag 143340 ggttatcttg ttccacgtat atatacagga aacatcgtgc tacatgacct cttgtaatcg 143400 ttcccataca taccactaac attctgtgta aacatatttt aaaatagtac aaaacatttt 143460 tgaaaattac taagtaatac atgcccattg taacaaaatt gaaaagtaca agaatatgga 143520 tatcttctta taatatatgt gtgtatgcgt gtgtgtgtgt gtgtgtgtgt gtgtgcatgt 143580 atataaagta aataaagctg ggcacggtga gtaatcccaa cacttttgga ggcctagacc 143640 agtggatcac ctgaggtcag gagttcgaga ccagcctggc caacatggtg aaaccccatc 143700 tctactaaaa atacaaaaat cagccgagtg tggtgatgca tggctgtaat cccagctact 143760 cgggaagctg aggccggaga atgtcttgaa cccgggacgt ggaggttgca gtgagctgag 143820 attgcgccac tgcactctag cctgggtaac agagcgagac tccgtctcag aaaatatatc 143880 taaataaagt aaataaaata gtccctcttc atcctgcatc cctaatcttt aattcttctc 143940 ttagagagca agggttagca aatctggccc actgcctgct ttttatatgg ctcttgagct 144000 aagaatgatg tgtgtatttt taaatagaag aaatctaaac aggaagaata ttttatgaca 144060 tttgaaaatc gtattaaatt tagatatcag tgtccataaa taaaacttta ttggaacatg 144120 gccaatgtat tttttttctt tttttttctg cagacagggt tttcctctgt tgtccaggct 144180 ggagtgcagt gccacagtca tggcatggta gcctccagct cctcggctga atcaatcctc 144240 ctgccttctg agtagctcct gggaccacag gcatgcagca ccatgcctgg ctaatttatt 144300 tttattttta ttttgtggag acaggtctca ctatgtttcc caggctggtt tcaaactctt 144360 ggcctcaagg aatcctcccg ttttggcctc ccaaagtgct gggattacag gtgtgagcca 144420 ccgcacgtgt cctgttcttt aaagcatcgt ctacagctgc ttcaactcgg cagggctgag 144480 ttggtgccat ggcaactgta agatccataa agctgaaaag attgaccgtt agctgtttaa 144540 ggaaacatat gctgacttct attaatagtt tgatgaatgt cttcccaaac tttcagattt 144600 gcagataaaa tgtatgcatg tgcatatttt gtagtggttt tgggggtggc tgacagcggg 144660 agttgtttta gaaaaaaatt aagccagagc tgggcacggt agcgcatgcc tgtagtccca 144720 gcacttttgt aagccaaggg cgaatggatc gcttcagttc aggagttcaa gatgagcctg 144780 gacaacatga tgagacccct gtcttgacaa aaaatacaaa aattatctgg gcatggtggc 144840 acgtatctgt agtcccagct acttgggagg ctgaggcagg agaatcgctt gaacccagga 144900 agcataggtt gtggtgagcc gaggtcgcac cactgcactc cagcctgggc gacagagcga 144960 gaccctatct caaaaagaaa aaaaaaaaag aagaaaaaaa ttaagccatt gggctgggcg 145020 cagcggctca cacctgtaat cctaaaactt tgggaggcca agataggcag attgcctgag 145080 gtcaggagtt tgagaccagc ctgggcaaca tggtgaaacg ccatctctac taaaatacaa 145140 caacaaaaaa atcagccagg tgtggtggcg ggcgcatgta atcccagcta cgcgggaggg 145200 aggctgaggc acgggaattg cttgaacccg ggaggcggag gttgcagtga gccgagactg 145260 tgccactgca ctccagcctg gacaacaaag tgaaactctg tctcaaaaaa aaaaaaaaaa 145320 gccattgcat acaaactgtt ttgctgtggc accatccttt tattccttta cacacttgta 145380 tggttccctc cctacctctt gtcattcagg tttttgttaa aaaataacct tccccattac 145440 ctttgttaaa attgcaaaac ccgcacactt ggtacacccg ttcccctttt tgctgtgttt 145500 ttgccattca gcaagcacta ttctactagt gttcgtttct cctgcggccc tggaatctgg 145560 ggcaggggtc tttgtttcct tccccttccc cagcttttag ctcagcacct gaggcgtggc 145620 aggccctttg cacatgcatg ttacaggacc gtgtgcacag gttcagctgc tcctggatgc 145680 tgttatcgcg ggtgcatgtc ccaccttcag acctgagttt tgcccaccag gtgttcgtcg 145740 gctcattcct cctttagtct tcactctgcc aagctaggca gtctcacaca tgtgcactca 145800 cgtggccggg tgtccccttt gcccacagac gcggatcttg gtcacgcaca gcatgagcta 145860 cttgccgcag gtggacgtca tcatcgtcat gagtggcggc aagatctctg agatgggctc 145920 ctaccaggag ctgctggctc gagacggcgc cttcgctgag ttcctgcgta cctatgccag 145980 cacagagcag gagcaggatg cagaggagaa cggtaggggc agccccaggg ttccacccac 146040 tcagggtgtc tggcaccttg aagggccaca ttggcctctt tgaggttgcc accagccact 146100 tggggaaggc ggctcctcag ggcatgaggg tgggagctgg atggagcccc ctaaagaagc 146160 aatgtggaaa accaccttag tccctgcagt gctgaactgg gagagagtct cggtgcttta 146220 tggccagggg atgggagcac caggcttcag ctcagctgac ctcagggcag ggtctagcgc 146280 cttcctggaa catgaccttg gacctgatga gtttcagggt ccttatggca aaaatgggaa 146340 tgatggtaat taaagtcctg gctctcgggg ctgagagaaa ctgaggacat acgtgacaca 146400 agagatgtga gggttgtgag gtgaagcacg gagttaagct ggcaggctcg ggttggtgac 146460 gtctgggttc aatccccggc cgctcatctc cccagctatg tgacctgagg cctgcccttc 146520 agacccatct gagcttcact ttcctccctc ataaagcagt tcagcagggc cagacgtggt 146580 ggttcccagc acttgtaatc ccaacacata gagaggctga ggtgggagga tcgctccagc 146640 tcaggagttt gagaccatcc tcagtagcat ggcgaaacct catctctaca aaaaatacaa 146700 aaaatttgcc aggcacagtg gctcacgcct gtaatcccag cactttggga ggccgtggtg 146760 ggtggatccc ttgaagccag gaggaattca agaccagcct ggccaacata ctgaaacccc 146820 aactctacaa aaaaaaaaaa aaaaaaattc agatgctatt aagtgctttg gaggggaaac 146880 aaaaaagaca atgccatggg ctgaggagtg atgggtgtca ttgtggcaac tcaggcaggg 146940 gatagggaaa ccctctctgg ggaggttgca ttggcatggg aaggagccag cagggagaag 147000 atctgggaag tgttgtgggc agagggaaca gccagtacaa aggcctcagg accagcatga 147060 gctcaatttg tttacaaaac aaaaagggtg gtgtggccag accatggtgt gccaggacgt 147120 ggggggcagg agaagaggtc agcacagtga ttgtcctgca gggccttcca ggtgggtttt 147180 ggtctaactg ccctgggaag ccactgagtg tcagagaggc aaagtgacca gccccaggat 147240 acacagcagc tgctggcagg gttggttctc aagttggtct ctgagtttct catcctttgc 147300 ctggggtggg agctccttct ctgcagaggt cctagtgatc tctaataagt gctttcttga 147360 gatgtaattc acacacgtag gctgggcgca gtggctcacg cctgtaatcc cagcactgtg 147420 ggaggctgac acaggtggat cacctgaggt caggagttgg agaccagcct ggccaacatg 147480 atgaaaccct gtctctacta aaaatacaaa aattatcctg gcgtggtggc gcacgcctat 147540 aggcccagct actggggagg ctgaggcagg agaatagttt gaaccttgga ggcggaggtt 147600 gcagtgaacc gagatcgtgc cactacactc cagcttgggc aacagagcaa gacttcgtct 147660 cagaaaaaca aaacaaaaca aaacaaaaat tcatacaaca tacaattaac ccacttaaat 147720 cacaaaatcc aaccatcacc acagtcaggt ttagaacttt ttttaatcac ccccaaaaga 147780 aaccccaatc catcagccat gactccctat tttccccagc acctccgaag ccctaggcaa 147840 ccactaatct ttctgtctct ctagatttgc ttattctgga catttcatat aaatgccatc 147900 acaataggtg gaatgttgtg actggcggct tttacactta gcgtggtgtt ttcaaggttc 147960 gtctatgttg tagcttcatt tccttttatt gcggaataat atgccattgt gcagatagac 148020 catactgtgt tgatctgttc actggttgat ggacattcag gttttttcca ctttctgact 148080 cttgtgaata ctgctgtcat gagccctggt ggttttaaag gaaaagttgg tggccgggtg 148140 tggtggtttg tgcctgtaat cccaccactt tgggaggcca aggcgggtgg atcacttgag 148200 gttaggagtt caagaccagc ctgggcagca tggtgaaacc tcgtctctac tgaaagtaca 148260 aacattagct gggatggtgg tgcacacctg tagtcccggc tattcgggag gctgaggtgg 148320 gggaatcgct tgagcctggg agtcaggctg ctgtgagcca aaatcatgcc actgcactcc 148380 atctggcctg ggtgacagag caagaccatg tctcaaaata cagttggatt tttgtttctt 148440 gccagtgcat gatagctgac attcccttca gcttttaaat tatttgatta gactgaattt 148500 ctgcatgttc attcccttgt ggttgggaag ttctaccttg agtctagcct gtttcttctt 148560 gctgcagaat ccccctttgt ctatctctca gcccgagcaa tgcattgtgg caacttctcg 148620 gtgacttttt cactgacctg cttggcaggc tacttttagg tgacaatacc ctttgtgctc 148680 tctaaatcaa aatgtgtggg tttagctgaa tcttttgccc agcgtgaggt ctgtctctct 148740 acccttccgt ccaggtgagc aaaaaatgtc cttaaactct cttggcccca gataggttcc 148800 gcacccccgc ctttctttcc cagctgctag agtatccaag cagtgtatac agaacatgga 148860 aggctgccag atgctttgtg atttttgtac acatcagcac ttaatttggt gatgcaaatg 148920 ccgcccacca ccctggcacc tcgtgcgttc attttcccag tttgacctcc ctacctcctg 148980 cctttgaggt tacatagaag tccttggcag tgggtcttac atcaaactgg ggcacccccc 149040 tctctcacca cccacccttt tccattgctc tggaggggcc ctggctataa agtcttgaca 149100 tcagggtctg gtcttgccca gccttagcca actcgaagcg ccaatgacct tgggtttgtt 149160 taaaccacat ttttggctct tcctaaaggg gaactttttt ccttgttgga ttaatcagct 149220 ctttttttta gaacacccag gctgaagggg tgcaggtgtt ggtatttggt ttgggagaat 149280 ccttgagggg ggatgggcag gaaccaggct tgtgaatggg gccataccga cctctctccc 149340 gggatattca gtttactgat ttctaagaaa tatatctttt ttactgtttg tctccctctc 149400 tccttttttt tttttttttt tttttaactt ttaatggcat tccttttatt cctaatttat 149460 tcccatgcca taagcttttg tttcttcaat ttcttctggg atatattttt cttctgtgca 149520 gcctcccctt ccggtttagg aacagtttgt tccctttcag gcaggatcat ctggatgtgg 149580 cagagtgagc tcacgtatgg gttaatccga ccgaccctga gctctgtagg tccggcgacg 149640 caacttaggt gctttcttca gttggatatg ctcaaggacc agagaatctg catctgaacc 149700 cttaagttca gtgtgactct ctgtattttt aagcatgtgc agcagaaatt cagtgctctt 149760 tttgggccgc cgaccttgtg gccagcccca cttcttggcc tgggtacatc taccaactcc 149820 accattataa tgtcagaatg gtacatgttg tttctgtaaa gtggcatctt tctgatactt 149880 tgtggccttt tgtacgtgca tacctttgat ggcctgggcg ctttcaggag tgttcttttt 149940 ctttttcttt tttttgagac ggagtcttgc tctgtcgccc aggctggagt gcagtggcgc 150000 gatcttggct ccctgcaagc tctgccgccc aggttcacgc cattctcctg cctcagcctc 150060 ccgagtagct gggactacag gcgcccgcca ccatgcccag ctaatttttt ttgtattttt 150120 agtagaaacg gggtttcacc gtgttagtca ggatggtctc gatctcttga cgtcatgatc 150180 cgcccgcctc ggcctcccaa agtgctggga ttacaggcgt gagccactgc gcctggcctt 150240 tttttttttt tttttttttt gatacagagt ctcacttgtt gcccaggctg gagtgtagtg 150300 gcacgatctt ggctcactgc agcctccacc tcccgggttc aagaaattct tgtgcctcag 150360 cctctcgagt agctggagtt acaggcatgt gccaccacgc ccagctaatt tttgtatttt 150420 tagtagagat ggggtttcac catgctgacc aggctggtct caaactcctg gcctcaaggg 150480 atcctcctgc ctcagcctcc caaagtgttg ggataacagg catgagccac catgcccggc 150540 ctcacaaatg ttcttaaggt gaacacgaag atttgaacct cttgatctgc atgattctgt 150600 ggtgttttct ggataaagtg aatagtgaac cattttcaca gattgcctca agccccttag 150660 gggaacaaat ttttaaggga tttaaaaaaa tggctcatta accttcatac ctggaaggta 150720 aaacacatct tcatgactct ggtttctttc ttaggaacct aatacctaga gcagtggttt 150780 tccatcaggg gcaaattgcc cccaccctgg ggacagttgg caatgtttgg agacatgttg 150840 ggatgtcaaa actggagtgg ggtttgcccc tggcaggcaa gcagggtaga ggccagcgat 150900 gtcgctaaac atcctacagc actcaagacg aattccccct taccctgccc cccgtgacag 150960 ggaatcccct tgccaggaca tccaaagcac cacgagcaag aaaccctgtg tgctccgact 151020 tcacactgct gaattcttcc cttgtcctct tgggagaagg atctttattc caacaatgtg 151080 gccatttttc tcttttaaaa aattttattt atatattttt atgttttttt atggagatgg 151140 gatatcagtc tgttgcccag gctggtctcg aactcctggg ctcaagcgat cctcccacct 151200 tgacctccca aaatgcaaat gctgggatta taagcatgag tcgcggcacc tggcccgtgg 151260 ccatttttca aaaccttgct tgaaccatct gttaacctca tggcaaatat ttttccctct 151320 taagtattta ccgagttttt cttaatgatt ataaaagcaa catgtgctca tcgtagacat 151380 ttgcaaacta caaaagagta caaagaatca ggaaaaaagg tggctcatat gtgtaatgcc 151440 aggactttgg gaggccaagg taggcggatc acctgagggc aggagttcga gaccagcctc 151500 gccaacatgg tgaaacccca tctctactaa aaatacagaa atgtcaggag gctgaggcag 151560 gagaatagcg tgaatccggg gggcagagct tgcagtgagc caagattgtg ccactgcact 151620 ctagcctggg taacagagcg agactgtctc aaaaaaaaaa caaaaaaaca aaaaaaaact 151680 cccgagaaag aacatctttc tgccctcact gcccagaagg ggagctgttg ttagctttgg 151740 catctttttc acctgtcctt ccttcctagg ccttctccct tgacaagatt gagagtatat 151800 cttagagttt tctcatctcc tgccaccttt tgatttcttt tcttaacagt gggccataag 151860 cacctcccca agttacacaa attagttgtc agcacagagc agctgccgag agagttcatc 151920 agacagaccc ccacattcct tctggctgtc ctcagaggcc ggatttcttc ctcttttgag 151980 gatgaagagc tttctctgcc gaggctgggg gaggaggtca gtgaggcagc cagtgaatgc 152040 cgtttttggt caaaaatgag gcgttgacta taaagctgtg agttgaattc ttccctccgg 152100 ggaggctggc ctgctggacc ttgcccaagc agagttccag aaccttcttg agtaaaggca 152160 gtgttggtgg aataaacagt gagaggactg gcaacggaat acacagaccc ggggcagcac 152220 ttaacgtacg tgggtcaagg gtagaaacag cacctggctt gacagcatcc aaaacccaac 152280 acctggtggt tgcatgaact cagtgacagt cactgaatta caagtttcgt gtgtttgctt 152340 taaaaaaaaa aagaaagaac tcttgctact ttatagcatt ctccaccctg gcccccagcc 152400 ttcatgtccc tcttcttccc tgctttgatt actttgtggc acttattgct gcctggagta 152460 aattatggat ctacttgttc atttattgtt gatctcttcc tttggaattt aagatctgag 152520 ggttttgttt gtttgttttg ttttgttttg tttgttttgg gagtctcacg ctgttgccca 152580 ggctggagtg caatggtgca atctcggctc actgcaacct ccacctcctg ggtccaagtg 152640 attctcctgc cgcaacctcc caagtagctg ggattacgga tgcctgccac cacgcccggc 152700 taatttttgt atttttagta gagacggcgt tgtgccacat tggtcaggct ggtcttgaac 152760 tccggacctc aagtgatcca cccgcctcag cctcccaaag tgctgggatt acaggcatga 152820 gccatcgtgc ccggctgctc tgagggcttt ttggttgtct ctccatcccc aggactaaga 152880 aaagagcctg acacatagta gacactcagt aaatgtgtta aatgagtgga tgaatcgcac 152940 cttggctgtt caaggcatgt cctgcataag cagtgggtag gccggagggc tttggatgtt 153000 tacactgcag ataaatacct cagactagga gaaaatagga gtggatttca ccccctctca 153060 ggtctgcttt agaaagcagc tttgtcagtc ctgcctatga gaggggcccc tctggcattg 153120 ggaagtcagc tctgcttctt gacttgacta tacacttgtc agtctgccca tctgtctgtc 153180 gggtgtgtac agagtgcctg ctgtgtgcca caaggccacc tggtacgtga gcctctgtgt 153240 ggaatggtgc cccccacgtt gagttgtgca gtgtgcatct tgtgtaactg cacttggcca 153300 cctgctgtgc caggtgctgg tgatacagta atggatatga cccacttcat gcccttgaga 153360 gctcacagtc tgatgggaga gacaaacgcc aaacaattaa gggtatcata gtgctaaatg 153420 cagtgatgga gggctgcttg agggcctggg aaatcacaga gaaggagccc ccatcccagc 153480 ctgggagggt ccagggtgat atctgggcta agtcaccttt tcttctcctc ttgggcacat 153540 gtgcatctgg ctctgtgtgg ggccagcccc tctcaggagc agtgtctgtc ctcaaagggg 153600 ctggagctga tgcccatgcc acctcccagt gtcatgcctg gcctgcctac tgtaatactt 153660 tatttctttt cctctcctgc gtaaaaacaa gcctgaagac tgaaggttgg tctgcattat 153720 ttgtttagct ctatttatgg ttaaacacag ttatgacttt ggccaggcat ggtggctcac 153780 gcctgtaatc ctagcacttt gggaggccaa ggcaggtgta tcagctgagg tcaggagttt 153840 gagaccagcc tggccaacat ggcaaaaccc cgtctctact aaaaatacga aaattagcca 153900 ggtgtggtgg cgggcacctg taatcccagc tatttgggag gctgaggctg gagaattgct 153960 tgaacctggg tggcggaggt tgcggtgagc taagatcacg ccacttccct ccagcctggg 154020 ctaaagagtg aaactctgtc acaaacaaac aaacaaaaac ccaacacagt tatgactttg 154080 gagaaagggg ttggtcttgt gcagtgtgct tgtcccggat ccacccagca cgtgtgggat 154140 ggggaaactg acgcacaaat ggagcagacc cttcagccat tcttgcctct ccccctttag 154200 aaaagacact cccttcactc ctttatttag ataggggctt agggcgggag tttcgctttg 154260 cttcttaaca atatcttggg tcttctgaat tcccaggcag cacagtgatg gacgaggagg 154320 aagcaggtca gtactgcccg ggttggagtt ggcttggctc atagaatgag gccagagacg 154380 ggccgagact gtcgctgcat gtctggggag gtgccgtcag atgtctgtgt tttcacccct 154440 ccggttgttc attggttcat ttagcacaca tttactgggt acctactgtg tgtctggctt 154500 tgaggctggc actgggggat acagcctgag tccccagatc cctttattgt cactgatgac 154560 cttgggtaag ctctactgtt tcatgcatca cgttaccgtg accagcatgc cttgagggga 154620 ccatgcttat gaagtgcctg gcacacagtg gatggacaat aaatggcaac agtttgattg 154680 tgagctgcca cgcatagatc ctggggcaca gtcaagacac acatgggccc agacaatgca 154740 gggtgatcag cgcctgttgg ggaactgcag caggtggtgg tggggaccct gaagagggat 154800 gtcgcctagt ggaattccag tggccagact ggacccatcc ctcctgcctt ctgcagtgtg 154860 tggcttaggg tcccagccaa gggctttttt tgtaagcagc agaagctgaa tctggccacc 154920 ttaaacaaac agagggtgtt tcctggaagg ataccaggta actcatgaat caaaggcaga 154980 actgagcaag taggactcag gaaatgggaa ctctgggaga ctagactctt ttaggacagg 155040 tgaacttgaa ctgtctttgg tccttgtaga ccactgatga cggttcaaat cctgggagag 155100 gggcttttat ggggcgacct cagacagtgc ccaccttggc tgggggaatc tgaggcaccc 155160 tgattgacag gcccaccaag gctgtaggaa gagggagagc tgatcccttc aaaaagccaa 155220 cagggggcca ggcacagtgg ctcacacctg taatcccagc actctgggag gccgaggtgg 155280 gtggatcacc tgaggtcagg ggtttgagac cagcctggcc aacatggtga aaccccgtct 155340 ctactagaaa tacaaaagaa ttagccaggc acggtggtgc atgcctgtaa tcccagcttc 155400 ctgggaggct gaggtgggag gatcgattga acccaagagg cagaggttgc agtgagccaa 155460 gatggcacca gtgcaatcca gcctgggcga cagagaagac cttgtctcaa gacaaggaaa 155520 aaaaaaaatg ctgagaggat ggtggactaa ctgatgttca gattcctcct cttaggcgct 155580 tggtcctcct ccgtgcagag tggaattttc cagctgccca gttcgacctg tgggctaatt 155640 ggtgggttga gagggtaaga cagccttagc gagcactgca tgcctgcaga agctcccagc 155700 tgaccatggt ggctgcgctc agtgacgaac aggagaagtg aaggctgagg cttataggag 155760 ggtggcctga ggctgctggt aggagagcgg gggggctctc tgcggcatgc agcctccaga 155820 tgggggtccc tgggagtgtt ctggaacatt ctcatccctg cacagagaaa gatggttaag 155880 ggcatggctg gttcccagtg tcacacatgt gtgtgaggac aggctgcatg ggaagtcctg 155940 cttggtatca ttcttccttc ctgggtgatg tggctatttg tgttttgttt gttttttaag 156000 ttagtgttta gttagtttag acaaaacaaa acagatgctg acattaaagg gaatgtttaa 156060 agcagagttt ctcagttcct ggctgtgcct agaattctct gtagaacctg tttaaaaatg 156120 tatttagtaa taagcaacac gggggtcgcc atcactgaac acttgctgtg ccaggcactg 156180 cgtgcagtct cgtttcaccc tctcgcaaat gaaggttggg tctgctgttc ctgttttgca 156240 gatgtggaag atgaggctca gacagattta tcatttcccc aaggggcaca gccaggaagt 156300 gagagaacac ttcccacata tcacagttcc tggagctcta atcgagactc atagcaggga 156360 ctgggctgga cacgagggca cctgctcagt ttttaatttt aattttttgg tttattttct 156420 tttattcgtg ttttttagat ttttttttta tttttatttt ttatttttat ttttagacag 156480 agtctcgctc tgtcacccag gctggagtgt ggtagcatga tttcagctca ctgcaacctc 156540 cgcctcccgg gttcaagcaa ttctagagcc tcagcctccc gagtaggtgg gattacaggc 156600 atgcaccacc acgcccagct aatttttgta tttttagaat agagttgggg tttttccatg 156660 ttggccaggc tggtcttgaa ctcctggcct caagcgatct gcccgcctcg gccttgaaag 156720 tgctggggat tacaggtgtg agccaccgtg cccggcggcc acctgctcat ttataaagcc 156780 ccccgtgact catttacaac caagactgag aattcctggc atggagtgcc tccctctgtc 156840 caggaatgat ctgcagcccc ctcttccctt ccaggtgtgt ctgtgtctcc ctgtggctgt 156900 ttctgcaaga ttttgcattt ttgagctctg cttttattca tgtcatcacc cgagcatgtt 156960 cccagggtca ccctgaccat gctgctggct gcgtatttat cccttttgta tcttctgtcc 157020 tgggtcctct cccaccttct ctggggtcag ccctgtggtg ccttacattg tgctgctttc 157080 tctcctggca ccaaagaatg aggcagtcag tgcggagtgg gggcagtagt catcatcatc 157140 actgagttat tgtgaaccgg gaaagagata tgatctgtgt tgacacgaca cacggtgccc 157200 aagtgcactt gataaatgtt ggctgtcatt gtcattgttg atgttccggt gattattgtt 157260 gatgctgggt ggattcttcc tgggatcagg gcagatatcc agctgctgtg tcccttggtg 157320 tccttatcag tgtccttcct aattctgcaa ccaaggcatc tgccagggct ggggtctcat 157380 ctgaagactc aatcagggaa gggtccactt tgaagctcac ctggttgttg gcagaacttg 157440 gttccccagt tcaaatgttg aaatacttta ttactgtgga aacagccact gccccaggta 157500 ccttttaccc tgaactcttg ggacctctct gtggtctagg aactgaaggg ttaactcctg 157560 gcactacagg ggtctccggg cctctgcctg ttggctgatg gccttgtcaa attggttatc 157620 tattttgaat atcacttctt ctttcaatgc ttgggaatca cggggctatg ccctttccct 157680 catgcgtttc cttgcatcct ggtcctagga agtgagctta acatagcagg gctactgttt 157740 tctgggctgg gttttaccca ttgctgctgg cacaggatgc tggctcaggc ccagtgccct 157800 cagtggatgg agccttctgc acagttgcaa agcactgtcc ctaccccaag ggactgagct 157860 ccagatacca cctgccccac aaccagacag cctgttcatg gcctctgcag agcaggtctc 157920 ctactttctg atcatcctgg cggccaggtg ctctgtggtc tcctcactga agtggccggt 157980 ttttgttgcc cttggtttta gcatctgcct catataaccc cacttgcccc ctttgtctct 158040 cttctgccag gggtcacggg cgtcagcggt ccagggaagg aagcaaagca aatggagaat 158100 ggcatgctgg tgacggacag tgcagggaag caactgcaga ggtaagggcg gggaggaagg 158160 ccccaaccta aggaccctgc cctgccagtg ggaggacaag aggaggaaca aaaaaaggcc 158220 tcagccccct gaggtcctgg aaggcctggg cttttacctt ccctcccaaa tcctccaagg 158280 accttgcttt tcagagtaca gaggcccaaa gaaggaatgt ggcactcttt ttgccaggtg 158340 gcacaactca cacaggcctc atgatttaac cagctgtcca cgcttctgac actcgggctc 158400 cctacatggt gtgggtcttt gctcaggtct cttggcgggg cctggaaggt tcaggctttg 158460 tgaagcagca tttgatttaa aactgtctca aggccaggtg tggtggctcc tgcttgtaat 158520 ctcagcactt tgggaggttg aggcaggagg atcgcttgag gccaggagtt tgagaccaca 158580 gtgggtaaca tagcaagacc tcatctctac aaaaaaggaa gtatgctcgt gtttgattat 158640 agagggcttc cttagatccc tggggattta tagcgtatgc agtatattaa ccatcctagc 158700 ttttaaaaaa ctggctaagt cggccaggca gggtggctca tgcctataat cccagcactt 158760 cgggaggctg aggcgggcgg atcacctgag gacaggagtt gaagaccagc ctggccaaca 158820 tgatgaaacc ctgtctctac taaagataca aaaattagcc aggcatggtg gcaggcgcct 158880 gtagtcccag ctactcggga ggctgaggca cgagaatcgc ttgaacccag gaggtggagg 158940 ttgcagtgag ccgagattgc gccatggcac tccagcctgg gtgacagagc gagactccat 159000 ctcaaaaaac aaaaacaaaa caaaacagca gcagcagcag aaaacagtaa aacaacaaca 159060 aaaattgaca aagtcggagc ctaaacgtat cagaccgcgg agatctgaga aaggatcccg 159120 gacctgcagt tgctacaggg gtcaggagag agcaaagacc atgcggcata gcacggtgcc 159180 tggaacagac aaacacttcg tagatgtcgc ttttgccatg gttatcatcc ggacatggtt 159240 atggtccgga attggtgggt cttggtctca ctgacttcaa gaatgaagcc gcagaccctc 159300 acggtgagtg ttacagttct taaaggtggc acgtctgggg tttgttcctt ctgctgttcg 159360 gatgtgttcg gagtttcttc cttctggtgg gttcgtggtc tcgctggcct caggagtgaa 159420 gctgcagacc ttcgcggtaa gtgttacagc tcttaaggtg gcgtgtctgg agtcgttcgt 159480 tcctcccgct gggtttgtgc tctggctggc ttcaggagtg aagctgtaga ccttgatggt 159540 gagtgttaca gctcacaaag gcaatgtgga cccaaacact gagcagcaga aagatttatc 159600 gcaaagagtg aaacaataaa gcttccacag tttggaaggg taccccagta ggtggccact 159660 gctggctctg gcagccagct tttattctct tatctggccc tacccacatc ctgctgattg 159720 gtccatttta cagagagccg attggtctgt ttttacagag tgttgattgg tccgttttga 159780 cagggtgctg attggtgtgt ttacaacccc tgagctagat acgtaagttc cccacatccc 159840 cactagatta gctagatata gagtgttgat tggtgcattc acaaaccctg agctagacac 159900 agggtgctga ttggtgtgtt tacaaacctt gagctagata cagagtgctg attggtgtat 159960 ttacaatccc ttagctagac ataaagggcc tccaagtcag caccagactc aggagcccag 160020 ctggcttcac caggtggatg ccacactggg gctgcaggtg gagctgcctg ccagtcccgt 160080 gccgtgcgcc ctcactcctc agcccttggg cggtggaagg gactgggcgc catggagcag 160140 gggcggcact cgtccgggag gctcgggccg cgcaggagcc catagcgggg aggtggggag 160200 gctcaggcat ggcaggctgc aggtcccgag ccctgccccg cggggaggca gctaaagccc 160260 ggtgagaaat caagtgcagc agctgctggc ccaggtgcta agcccctcac tacccgggct 160320 ggcggggctg cccggcagct ctgagtgcgg ggtccaccga gccgacgccc acccagaact 160380 agcgctggcc cgcaagcgcc ctgtgcagct ccggttccct cccgttcctc tccctccaca 160440 cctccccgca agctgaggga gccggctcca gccttggcca gcccagaaag gggctcccac 160500 agtgcagcgg cgggctgaag ggctcctcaa gcgctgccag agtgggtgcc aaggccgagg 160560 aggcacagag agcgagcgag ggctgcgagg gctgccagca cgctgtcact tctcaatctt 160620 acacagccta aattctagtg ggagactcca gacagtgcat gagtgtagaa ggatgtaaga 160680 ttttctgtcg aggtgtgtgg atgtgtgaag tcctaggtca tgaagcagga agccccagct 160740 ccccatttga attctagatt ccatccagag ttggttccag ttgctccctc tgccactccc 160800 tgaaaactca ctcttgcttt cagatttgag ggccacttcc acctcactag gccttaacta 160860 aagacctttg cacagatctc atgggtaagg aaagtttacc caatcccagg cgctaattca 160920 aagaggggag gtggtggagg tttattcggc cttcaggaag tgttttcagg ggacacagtt 160980 ctgggggtgc agggatgact catatggggc tcttgacctc agttagctta taatcttgtg 161040 caggagataa gtgggtagag gaaagtatag aaatttccac ggcagtgagc cgcagctgtg 161100 ttttgcatgg tctccataat ttcttttctt ttcttttctt tttttttttt ttttgacatg 161160 agtctccctc tgtcgcccag gctggagtgc agtgtgcagt ggcgcgatgt cagccactga 161220 acggaaaact gtgggcgacg caatctgtga tcatctctgg gggtctgcat aaagctcatg 161280 accactgatg tgcgaaaagt gctttttttt ttttttttga gacagggtct tactcagtcg 161340 ctgaggctgg agtgcagtgg tgcaatcacg gctcactgca atttctgcct ctgggattca 161400 agcgattctc ctgcctcaac ctcccaagta gttgggactg caggtgcacg gtaccacgcc 161460 tggctaattt ttgtattttt agtagagacg gggtttcacc gtgttggcca ggctagtctt 161520 gaactcctgg cctcaagtga tccgcccacc tcggcctccc aaagtgctgg gattacaggt 161580 gtgagccact gcacctggcc aaataatgct ttctgagtaa cacgcttgca tgaaggagca 161640 gtcaggcaag atcccacccc agtgcccacc acatttgtaa aacaagaaaa tcgaactagc 161700 tgggtacttt gccctatgtt tttcatcata tgttacattt tgaatctttt tcatgtttga 161760 aaaatgatct acgatgtgcc ctttctgtta tatcttttat tggctttttt ttttttgaga 161820 tgaattctaa ttgatctcag aaaaaaaaaa aaaaagcacg cactttttat ataccagttg 161880 tcatgggctt tttgcaggcc cccagagatc atcacagatt gcgtttccca tgggtctcat 161940 tcctgcctga gacactgcct ttctctgggt acctataaac ctggagagtg acatggtggg 162000 gtgtggtgca tatattcata tatatgttta catgtgtgca tgtggaaaca ctccgtctct 162060 tatgccatgg ttcagaccca caatagcagt cccagcaggg agccctccga ccctgcccaa 162120 ggcatctgta cggttgacac ccttgtgctt tgcttctcca gacagctcag cagctcctcc 162180 tcctatagtg gggacatcag caggcaccac aacagcaccg cagaactgca gaaagctgag 162240 gccaagaagg aggagacctg gaagctgatg gaggctgaca aggcgcagac agggcaggtg 162300 agattcgctc cttaagtgat gacagtggct ggagtttata gagcgcccac tgtgcactgg 162360 gcactgtgca aagtgccttg tctatgttaa ctcacctgtc catcacaaca cacctgtgaa 162420 gatactattt gcagcaccag aaactgaggc cagagaggct aagtgactta ctcacggtca 162480 cccctggtca gcggcagaac tgggatttga accctggcca actccagggt tagtacttgt 162540 agtctctgct ctattgactg cctgagcagc tcaggggggt ctcattcgct agaggtgagc 162600 tggatgcttt aaatcagggc ttcctgcaac gtggggttca gttgtgcatg agatggtgtc 162660 cggttgtgca cagacgcatt aaatgacaga ggaatgtttg tttcatttct ttttttaatt 162720 tttatttttt tgagatggag tctcactctg tcaccaaggc tggagtgcag tggtgcgatc 162780 tcggctcact acaacctctg cctcctgggt tcaagcagtt ttcctgcctc agcctcctga 162840 gtagctggga ttacagaaac ttgctacctt gcccagctaa tttttgtatt tttagtagag 162900 acagggtttc accatgttgg ccaggctggt cttgaactcc tgacctcagg tgatccaccc 162960 accttggcct cccaaaatgc tgggattaca ggggtgagca ccgcgtcctg cctgtttttc 163020 atttctcatt tggtcctaat gattacgtcc ctgagaaagt cccagttggg tcctaccctg 163080 ccttctcaac ctatcaacca ctatcctctc tttgtaacaa ggagaccggg ttttgagctc 163140 ctgttttatt gtttttaaag atcgtctatt ttgggcaagt gttaataatt ctccatttat 163200 ggtggtgatc caaagtttat ttttaaaaat aaatgtggtt ttttttgttt ttgtttttaa 163260 agggaatgga atttttaaag taggtaaaaa ataagcatgc agataaagaa aaacaaaaaa 163320 aaaaacatga aaggtggtag ccggggagtg gggctggggc actttctctt agatctgccc 163380 ggatgtgtcc agagcttccg aggactgtct gttcctggct tcttccttaa cttgtcatca 163440 gagtcaggac cgtaacaagg ggcagaggtg actctggtgt cctctctcgc cttaccctta 163500 gtgaccctcc aggaagccag agaagttacc ccaaatcgca ggacatggga aggaagggcc 163560 agagatgcca ggcccattta atcctcattt aactccaatt ttatattcaa ggaacatcaa 163620 agccaggggg cttgttactt gtcaaagttg gacccagagt ggagccaggc acaacacgct 163680 tatcgtttct ttgtgtcttt tttttttttt tttttttttt tgagacgaag tcctgctgtg 163740 ttgcccaggc tgtagtgccg tggcgctcac cgcaacctcc gcctcccggg ttcaagcaat 163800 ttacctgcct cagcctcccg agtagctggg actacaggcc tgcgccacca tgcctagcta 163860 atttttgtat tttcggtaga gatggcgttt cactatgttg gccaggctgg tctcaaactc 163920 ctgaccttgt gatctgcctg cctcagcctc ccaaagagct ggtgctggga ttataggcat 163980 gagccactgc gcccggcctt tttttttttt ttaatttgtt ttcttttttt tttttctgag 164040 acaaggtctg actctgtcac ccaggatgga gtgcagtggc acaatcatgg ctaactgcag 164100 cctccacctc ccggattcaa gtgattctcc cacctcagcc ttccaagtag ctgtgactac 164160 atgtgtgcac ccccacgctt gactaatttt tttaattttt ttgtggagat gaggtttcgc 164220 cctgtcgccc agactggtct tgagctcctg ggctcaagtg actggcccgc ctcccaaagt 164280 actgggatta cagatgtgag ccaccacacc tggccacaca cttgtcattt ctgacccccg 164340 agcccaccac attccactac tcatgagaaa gaggttcctg aacgctgcag gctaatttca 164400 gggacagcag gcaacttggc cgcatgacaa agccaagtgg tgaaataaac acattcttaa 164460 ttatgacctg tctcctcacc cacatttttc attttccaga atggggactt gaaaactcaa 164520 aaggaagcag ccagttacac atcagacctg ttatctttca cctgttacct ttcagctaga 164580 ccgtagggtc agatgatttt tgtttttttt tctggtgagg ggcagagcct cactgtgtcg 164640 ctcaggctgg agtgcagtgg tgtgaccaac gctcactgca gccttaagct tctgggttca 164700 agagctcctc ctagctcagc ttcctgagta gctgggacta taggtgtgga ccaccacacc 164760 tagctaattt taaaattttt tgtagagaca gggtcttact gtgtttccca ggctggtctc 164820 aaactcctgg gctcaagtca ttgtcctgcc ttggcctccc aaagtgctgg cattataggt 164880 gtgagccacc gcacccagtc cagatgattt tcatgaccca aaattcagca tgaaaagctt 164940 gaaatgacaa tgagcacaga cacgggtaaa gatccctgga atttcttgaa accaagtcag 165000 gtggtttagg tgggggctgg cctaaagcag attgccctgt ctctcatgtc aggcggctag 165060 acacatttgt ttagccccat gctgggctcc acagggaata taggagggaa agaaactcca 165120 accttcacct cctggagcga actgggcact gggaagatgg gtgagatggt attctgtgct 165180 cagagtgaaa agagttggag gaggctggcc cagttgtggt gttgaggtga catttggcct 165240 tggttgccag gcaacatgtc acacgttgct taaaactcat tggtggcttc tgctttctgt 165300 cagtcttggc taaaagttgg aatcctgacc cgagtctccc atgccatgtg tggtctgact 165360 gcgaccggtt tttccagcct cttgttcctt gctgccccat gatctcctgg ctccagccac 165420 cagtgccttc tctcagttcc ccagatgcac tgtgttccct cctacctcag ggcctttgca 165480 catgctggtt ctgccacctt ttttccattt tcagctggtt taactccttt tttttttttt 165540 ccccctggag gcaatgtctc cctctgtcac ccaggctggt gtgcagtaag tttggcttgg 165600 tgcaacctcc acctcctggc ttcaagcgac ccttgtgcct cagcctacag gcatgtgccc 165660 ccacgcctga ctaatttttg tattttttgt agaggtgaga tttcatcatg ttggccaggc 165720 tggtctcgga ttcctgacct caggtgatcc acttgccgca gcccctcaaa gtgctgggat 165780 tacaggtgtg tgagccacga tgcccagcac tctttatttt tttttatttt ttagagacag 165840 tctcactctg tcacccacgc tggagtgcag tggcgcattc tcggctcact gtaacctccg 165900 cctactgggt tcaagccatt ctcttgcctc agcctcccga gtagctgaga tgacatgtgc 165960 ctaccaccat gcccagctaa tttttgtatt ttagtaggca aggggtttcg ccatgttagt 166020 caggctggtc tcaaactcct gacctcaggt aatccacccg cctcggccta ccgacgtgct 166080 gggatcacag gcatgagcca ctgcacccag ccttggttta actctttaat gtcacttcct 166140 cgaagaaaac ctcccccaat acctctctag actgcattag gtcaggttgt ctgattttat 166200 actcacgtgg aattgtgcac cgtttacagc ccttctctgt gatgacgcat ttatctggga 166260 tgattttatg ggagcctatc tcaccacgcg actggaagct ccatgcatga gggcagagac 166320 cctgagtttg tctctttttt ttgagacgga gtctcactct gtcgcccagg ctggagtgca 166380 gtggggcaat cttggctcac tgcttctacc tctgcctcct gggttcgagg aattctgcct 166440 cggccttcca attagctggg attacagatg ccgaccacac acccggctaa ctttatattt 166500 ttaatagagg caggattttg ccatattggc caggctggtc tcgaagtctc tacctcagtt 166560 gatctgcccg cctcagcctc ccaaaatgtt gggattacag gtgtgagcca cggcgcctgg 166620 ccctcgactt tgtttactgc tgactttgtt gaatagctaa aggggagggg tgttctacgt 166680 aggagcaaag gcaggcagct gggtggcaca gtgctggtga agcccccgac cttgtggggc 166740 tggggctggg gctgggtgcg tgcatgtgct aagctgcctt atctcctgtg atctccaggt 166800 caagctttcc gtgtactggg actacatgaa ggccatcgga ctcttcatct ccttcctcag 166860 catcttcctt ttcatgtgta accatgtgtc cgcgctggct tccaactatt ggctcagcct 166920 ctggactgat gaccccatcg tcaacgggac tcaggagcac acgaaagtcc ggctgagcgt 166980 ctatggagcc ctgggcattt cacaaggttg gtgccgctgt ctcccacccc gcctgatttg 167040 ggcccctgtt gtggctttgt ctaattatag aaatggatcc ttagagtcct cagcgttttg 167100 tgggacccca aaccaagcca aacccagaaa aatggtagct gtcagctagt agacactcag 167160 atatttgtag agtgggtgtt tgagtgcttt gttcatatgg gccttggtgg tagacgggag 167220 gagtgctcca gtgtgcccat tttacagatg aggacagttg agaacagagg cctctggaag 167280 cactgagggt tgggaggacc cccttgagca tgtttgcttt gtcacagtga cagagcttcc 167340 atgaggtctc atttgcggac ttttgcctgc tgagtgaggg cggaaattgg cttatactag 167400 taattcccaa ttatgggcag tgttgtccct cagggatgtt tgacaatatc tggagatgct 167460 tttggttgtc aaaagattga gaaaccctgc tgttggccag gcatggtggc tcacacctgt 167520 aatcccacac tttgggaggc tgaagtcaaa ggattgcttg aggccagata ttcgagacca 167580 gcctgggcaa catagtgaga ccctatttct agaaaaaata gataaataaa ataaactaca 167640 ggtcacgtgg tggtatgcgc ttgtggtctc agctacttgg gcagctgagg tcacaagatt 167700 gcttgagccc aggagtttga gcctacagtt agacctatga ttgcaccact gccctccagc 167760 ctgggtgaca gagcaagacc ctgtctcaaa aaataaacaa aaaaaaaaaa accctgctct 167820 atactgttct gtgtggtcct atgggagtcc tcaaatgcag cagcgttgat attaacagct 167880 ggcatttact gagcatttac ttggtgcttg gatttgttct aaacacttcc acgtgtttta 167940 acttatttta tccttgcagc agtcctgtga ggtaggagtt aatatttccc tcattttgga 168000 gatacagaaa ctgaggcccg gagaggttga gtcagttgcc aaaagtcaca cagctaatac 168060 atggcagcat tggcattgaa caaggcagtc tggctcagga gctcacgctg ttatccactg 168120 tgctacgcag tatgtgagcc atgtttgcaa atacacatgt atggtccata tgatatatac 168180 acagtaaatg gatagtcttg acacatttga gtacttctgt atgccaggca cattgccagg 168240 tggggacttc acattccaca gtgctccgag gtcagcgtca ttgtcccatt ttacagatga 168300 ggaaactgag agattcagtg accagtagga ggtcccatag ctggtaagtg gcagagatgg 168360 gatttggcag cattggctcc agagcctgtt acttgagccc ctgcctattg ggtgtcttcc 168420 cgattaaaga ggccgagatg gaagcctctc tgttcctagg aagttgctgc tctggaacac 168480 acagtgcgct cctgtggatt gtttgagaga agcaccagtg tctcaggatc tccaggaggt 168540 ggctttggga aaacccagcg gtagcagagc acacatggac tccttgagtc tctcaatccc 168600 tcccctcccc tctccttgcc attaggggaa aggactgtgg cctacaaatt ataattgagg 168660 gaaggtagag aacagagagg gtgtggtatt acctgaactc acacagcaac aacgtctgtt 168720 ccagagctgt gctgtctggt gcggtagtca caagacacag gtggctattt taatttcagc 168780 tgttaaaatt aaataaacgt tgggcgcagt agctcacgcc tgtaacccca acactttgag 168840 aggccaaggc gggtggatcg cttaatccag gggttcaaga ccagcctggg cagcatggca 168900 aaaccctgtt tctacaaaaa atacaaaaat tcgctgggcg tggtggcgca tgtctgtaat 168960 ccctgctact caggaggctg aggtgggagg attgcttgag cccaggaggt cgaggctgca 169020 gtgagccgtg atcacagccc tgtactccat cctgggtgac aggatgagag agaccccatc 169080 tcaaaagaaa aataaaatta aagatttatt cgattagact agacacgttt caagtgctca 169140 gtagccatca tttcagaaaa ttatctcagc actgttctaa aacagcgatc cctagccttt 169200 ttggcaccag ggactggttt catggaaatg gtgggtggtg atttcgggat gaaactgttc 169260 caccttagat catcaggcat tagttagatt atcagaagaa gcgcacagtc taggtccctt 169320 gcatgcacgg ttcacaatag ggttcgcact gctaggagga tctaatgcca ccactgagct 169380 cacaggaggc agagctcagg cgctgatgct caggaggtga ccaccactca cctcctgctg 169440 tggggcctgg ttcctaaccg gtcatgagct gctgccaatc tgtggccccg gggttgggga 169500 cccctggtct agaagaatat ggcatgggga ttaagagcag gctgtctgga ttaaaatccc 169560 agttctgctt ctgctaggca cagtatacta agggcaaagg cgttcaccta tctggacttc 169620 agttttctta tctgtaagtt gggtagtaat agaagttatt cagagtcatc ataaaaatca 169680 gttacatgta aaacccagca cagtgcttag cacataggaa gtaccctctg aataatagct 169740 gccattatca tcatcattat tattactatt tttttttttt tgagacggag tctcattctg 169800 tcgcccatgt tggagtggag tggacgcagt cttggctcac tgcaacctcc acctcccgga 169860 ttcaagcaat tcccttgcct cagcctcccg agtagctggg attacaggcg ccaaccacca 169920 cgcctggcta atttttgtat ttttaggaga gacggagttt cactgtgttg gccaggctgg 169980 tctcgatctc ctgacctcaa gtgatccacc cacctcggcc tcccaaagtg ctgggattac 170040 aggtgtgagc caccatgcct ggttcatcat tattattatt attagaagtt gggagtccag 170100 gcctgcctcg tccacatggc cactcctccc tgcagtgcct ggtcagctcc ctctctgcat 170160 tgtggagttt taactccgag tgtctgcagg gatcgccgtg tttggctact ccatggccgt 170220 gtccatcggg gggatcttgg cttcccgctg tctgcacgtg gacctgctgc acagcatcct 170280 gcggtcaccc atgagcttct ttgagcggac ccccagtggg aacctggtga accgcttctc 170340 caaggagctg gacacagtgg actccatgat cccggaggtc atcaagatgt tcatgggctc 170400 cctgttcaac gtcattggtg cctgcatcgt tatcctgctg gccacgccca tcgccgccat 170460 catcatcccg ccccttggcc tcatctactt cttcgtccag gtaaggggtg aggtcttagt 170520 gttcgggaca agccctactg tgcattatat accagtgtta cctaaagcct tgttttatct 170580 taccatgtcc ccagtgtggt gcttttgaag catgtagatt tgtttttgtc agtttcgaat 170640 acctaaattg tttttttgct cacaataaca aaatgcactt tttttgtgga atgcagtttt 170700 ttcctaagtt ttacttttcc acctgtcaat tcaaaaagga aacaaaacct atcactataa 170760 agacaacttc attattaaaa tttctttttt tttcttgaga cagagtctcg ctctgtcacc 170820 caggctggag tgcagtggca caatcttggc ttactgcaac ctccacctcc cagttcaagt 170880 gattcccctg cctcagcctc ctgagttaac aggtgcgcac caccacggcc ggctaatttt 170940 tgtattttta gtagagacag ggtttcacca gtgttggcca ggctggtctc aaactcctga 171000 gctcaggtga tccacccacc tcgacctccc caagtgttgg gattacagat gtgagccact 171060 gcgtccagcc taaaatttct tcaagtataa aattctttag ttcttaagcc tcctgcagga 171120 ggcaggaact aaacaaaaaa catgactaat agcagcctaa ataagataga cgttttcttt 171180 ttctctgtca taatagaaat ttagaggtag gctgttcagg gctggtatgg cagcttcatg 171240 agtttaatat cccagatacc tgcttttatt taaaaattta aaaaatctta ccatatttat 171300 acaagccttt cattctttct ttctttcttt ttttttttta atttgacatg gagtctcgct 171360 ctgtcgccca ggctggagtg cagtggcgcg atctcggctc actgcaagct ccacctctcg 171420 ggttcacacc attctcctgc ctcagcctcc cgagtagctg ggactacagg cgcccgccac 171480 tacgcccagc taattttttt tgtattttca gtagagacaa ggtttcacca tgttagccag 171540 gatggtctca atctcctgac ctcgtgattc gcctgcctca gcctcccaaa gtgctgggat 171600 tacaggcgtg agccactgcg cccggcccct ttcattctta agttggcctc atggtccaag 171660 gtggctgctg gagctccagc cattatatct atatttcagt cagtgagatc aaggaaggga 171720 agtagggcaa gggagcatat gggtgctgaa tcagcactac tcccttatct gcaggcacac 171780 attctaagac tcccccaatg gatgccttaa actgcagata gtattgaatc ctacatatcc 171840 tgtttttttc tgtacataca tacctatgat aaagtttaat ttataaattt ggcataatag 171900 attaatagca gtaatttata ataataaaat agaacaatta taacaatatg ccagtatcac 171960 tacttctcca cattagaggc gttattttta ttactttttt ttttgagaca gagtttagct 172020 gtgtccttca ggctggagtg cagtgatgga atctcggctc actgcaacat ctgcctcccg 172080 ggttcaagtg attctcttgc ctcagcctcc caagtagctg ggattacagg catgcgccac 172140 acccagctag tttttgtatt tttagtagag acgaggtttc accatgttgg ccaggctagt 172200 ctcaaactcc tgacgtcaag tgatccgccc gcctcagcct gccaaagtgc tgggattaca 172260 ggcattgacc cactgagccc agccaggggc attattgagt aaattcggat tacttaccca 172320 taagcactgc agtacaatgg ccgtcagtct gataaccgat atggctatta agtgactaaa 172380 ctgacaggga gggtctgcag catggacctg ctggacaaag ggatgattca caccgcggat 172440 gggactgggg gggatttcat cacactactc agaagggtgc acaatttaaa acttacacat 172500 tatttttgga ccacagttga ccatggataa ccgaaaccat gtgtgttagt ttgtcctcat 172560 actgctatga agaaataccc aatactgggt aatttattaa ggaaagaggt ttaattgact 172620 cacagttccg catggctgag gaggccatgg cagaaggaga agcaaacatg tccttcttca 172680 catggcagta ggaagaagaa tgagagcacc acgaagtcgg ggagccccct tataaaacca 172740 tcagatcttg tgagaactaa ctcactatca tgagggttgg gggaaactgc ccccacgatt 172800 cagttatctc cacctggtcc ctcccatgac acatggggat taagggaact acaattcaag 172860 atgaaatttg ggtggggaca cagccaaacc atataaccac ggaaagtgca accttggatt 172920 agagggacac ctgtacatct aattgtccag aacttagtca tgggaccacc tctattcaca 172980 agggaccctg gaaagtgccg tgttttagct gggcacattg cacttcccag caaaaacttt 173040 cagttgggcc taggcacggt ggctcacgcc tgtaacccta cccctttggg aggccgaggc 173100 gcgtgtatca cctgaagtca ggagttcgag agcagcctga ccaatatggt gaaaccccac 173160 ctctactaaa aatacaaaaa ttagccaggt gtggtggcat gtgcctatag tcccagctgc 173220 tctgaaggct gagacaggag aattgcttga acctgggagg tggaggttgc agtgagccaa 173280 gattgcatca ctgcaatcca gcctgggcaa cagagtgata ctctgtctaa aaaaaaacag 173340 agaagtttct gttgggaaag gagaaattgt gtaggcagtc agtcgtctct gctgcatccc 173400 ttctgcagaa acggttatat gttctttgtt ctttgaacac atgtggtttc ttaggatatc 173460 gcaggataga taatgttttc aattgacagg tggagcatct tgctaagtgg gagagctgag 173520 agtgcaacct caagtctgtc caattccaaa actgctgtta ccgctaaagg attaaccgca 173580 gcacaattgc cagtagggat gggttgttta gatgggagca ttccagctgc aaagcaaaac 173640 aagagtaaga aaccatgagg ctcaccatat ctcaaaccac gctgcacagc tgttcaggtg 173700 gcatccaggg ggccttggtt caatcatgtg gcccctgcgc cccaccacac tgtggcccaa 173760 tgattgatga gaacgaacag tgatggaatc agagagagta ggtccagttc ctggagtctc 173820 gttatatcct cttgaaattg gtgccagctt tttttttttt ttttttttcc cctgcattta 173880 ccaaatatgt tatctgtgtt catacgcaag ctggaaaatt tcctgaaaga cccaaaaaga 173940 acaaaacagg ccaaatgcag tgttgaaggc aacttaaatg tctgccaata gcaggacctt 174000 gggtacaccg tggagcaatg tggctttgag cagggataat tagaagacgc agctgttgga 174060 gcaccaagga tttttatttt tcaacaacaa aggaaatgat tttagcaaag gaccaagttc 174120 taggtgcact gtcgttatca ccgagatgaa atgcataatg tgtgtgggca ggactggaag 174180 ggaggcagat acatgaaaac atcgtctttt taagggttga gattatagaa tagttaattt 174240 tttaatggct tttggctaaa tttacattta tcctctcact aggcagtctc attcctaagt 174300 gtatattaaa aaaaaaaaaa aaaaaaaaag agcaaaggca gtgcttagaa tgttctcagc 174360 atcttgattc ataatcgccc aaactggaaa cagctcaaat gtccattaac aggaccgtgg 174420 agaaataaat tgtgatataa ttatacaatt tatggttgag tagtaaaaag gaatgaaatg 174480 ctaatacaca acaatttggg tttatctcag agatgttata gtgatcaaaa gaagccagac 174540 gaaaaagagt aggtactgtg agatttcatt tatatgaagt tcggtcgggt gcagtggctc 174600 atgcctttaa tcccagccct ttgggaggcc tagacaggag gattgcttgg gcccaggagt 174660 tcgagaccag cctgagcaac atgggaaaac ctggtctcta cagaaaatac aaaaattagc 174720 tgggtgtggt ggcgtgaacc tgtagtccca cctgcttggg aggctgagat ggaagggtca 174780 cttgagcctc ggaggcggag gttgcagtga gctgacattg tgccagtgca cttcagcctt 174840 ggtgacaggg cgagttgtct gaaaaaaaca tcagatcggc agggcaggtg gatcacctga 174900 ggtcaggagt ttgagaccag cctggccaac atggtgaaac cccatctcta ctaaaaatag 174960 aaaaattagc caggcacggt ggtgggcgcc tgcaattcca gctacttagg aggctaaggc 175020 aggagaattg cttgaacctg ggaggcagag gttgcaatga gccaagattg tgccactgca 175080 ctccagccag ggtgacagag cgagactgtc ttaaaaaata aaataagatc attcctgaac 175140 aaatattcat ctcaggttag atttttccag taagtaaggt tcagaggcag tggcaagtgg 175200 aggaaagtga acaggtaaca cacttgagag cgatttgcat ctggattgtt cagaaagcaa 175260 gctggtaaga gaggaaggag atgtggtcca gggtaagatg gggcagatca cctgggcctt 175320 cagccatgca gaggggtctg gatttcatgg gaggcggtgg gaacagctgg agaagaaatt 175380 atatctgatc cacattccag gaattggcag aacagctatt ctgagactgc gtggggttgt 175440 gcggtacctg ggttcactta catagcttct ggggccccag aagactctcc atctgtgggt 175500 tgcaattaac gcccgtgccg ccacccagga agaagctgcc aaccacagag gccttgtaaa 175560 agccacctgc tgctattgat gctttttgtt ggactctgcc ccaaagcagc ccagtacacc 175620 tggcccaggg caggatgcag ggaggccgag ttcctagcaa ccctttgtta gttttcccag 175680 ctctcctgtc gataagcaat tgtaggcacc ttgtggaatc aggaaccccg ggctcaccag 175740 ttccttttgc gtagatgaga aaaacctagg ctaggagagc gcagtgtcct cacatggctg 175800 gtgcagcctc tgatccacag ctccacaaag cttgcagaag gtggttggct tttgttctga 175860 atctaacaag acttatcggg aggctcttgg tgcctggcac tggctgaatg cccaggttgg 175920 gggaggcaga gcagatgaag catctgcccg cgagggtggg tggagctgct tgtgaaacgt 175980 atcatcgtag cccgggagct gggacactga agcccggaga aggtgctcat ggaggatggg 176040 aagggcttcc cgaggaagtg acatctgtgc tcccatctgc tgggtgatga ggaatggcct 176100 ggacgggatg ggcatggtgg gtggaggcag gcggcctgtg tgcagggaag gaaggggaga 176160 gttacaggat gagatgagtt gagggaagaa gcatggttgg caactctaac agcgctggga 176220 ggccatcgga ggggggtgac gagattgacc ctatcctcat gggcatctca gctgggctga 176280 gtgtgctgga accggccatt gcatggacac agtcactcct gaggggatgt gatcaacagg 176340 cggaattctg tcacttaatg ataacaatag tcaccagcta actgaatgct tactgttagg 176400 tcaaactata tgaaactgct aatacttatt tcttatctac agaaacagct atttcctgtg 176460 gttcaaccta gtattaccag gcactgtgct tagtgacatc atgcatatct atatgattta 176520 tgaaataatg tgtccacgca aatacacatc acatgtaaga ctgtaactct tacatgtcac 176580 cctcacaatg accccgtgaa gcaagctttg ttttgtttcg tttgttttct taataatatt 176640 ttatttttgt agagatggca ttttgccatg tgcctgggct ggtctcagac tcctggcctc 176700 aagtgatctc ccgcctctgc ctcctgaagt gcgggtatta caagcatgag ccaccccacc 176760 tggccgagca agccttgttg ttcccatttt acagataagg aaactgaggc ttagagaagt 176820 aaagtgttag tcgtgtttat attgccagtc agtagttgag tcaggatttg aactgaggtc 176880 tcgttgacct caaagcctat gctgaaaacc acactgctgg ttccagaaaa ccctagaggt 176940 gaaaggcttc agagaggcag tacagggtag aggttagcac tttgcagccc agatggcctg 177000 ggtttgaatc ccagttctgc cccttgctag ccatgtgacc ttggggagga gattaactag 177060 cttctttgtg ccttagtcta cccatcacat ataggaatga gcacctcagg ttttttgtga 177120 ggattgaatg aactgatgtt tgtaaaactg cttagaacga tgcctggggc tgtgggcttt 177180 gtataagcgt gagctattat tgtcactgtc cttgtcattg gtggtgctat tcctgtggtt 177240 caccaggtga gtgggcaccc ctgtgagggc agcccggctc taacattttg cctcctggag 177300 gtatcggtta cgtctagatg ttctccagca cagccctgcc ctgggaggat ggcaggaggg 177360 aaccttcatc aactccccgc gtctgttctc taccccagag gttctacgtg gcttcctccc 177420 ggcagctgaa gcgcctcgag tcggtcagcc gctccccggt ctattcccat ttcaacgaga 177480 ccttgctggg ggtcagcgtc attcgagcct tcgaggagca ggagcgcttc atccaccaga 177540 gtgacctgaa ggtggacgag aaccagaagg cctattaccc cagcatcgtg gccaacaggt 177600 gggcatggtg ggcctgcagg agcgggtgga ggaggccgcc ttagcacctt gtctctttgc 177660 ctcgatcttt tcctcgcacc ttgagctggg tataaagcca aaccccggcc ttgcagaaag 177720 gatggagagg cttgatgagc gcggaggaca gatgaatcat taagagcaga cagcggcact 177780 gtagacatgc agtgcccgcg gcatttaagt gcagggacac agctcttctg gagtcagaaa 177840 gccctgcaag tgcttcccgt taactgtcat cctagtgatg caagactgcc agcgaccgac 177900 tctgctattg agtatcttca taccgctgtt cccgtctggg ggtgatcatg cacccctggg 177960 tgatgtgtgt cagaagcaat ttactaatac taagctaaac catatgagat tgtcatcttg 178020 tgggccagat gtcatggctc acgcctgtaa tcccagtact ttgggaggct gaggcaggag 178080 gatccattag attccaggcc agcctgggca acatagcaag acccccatct ctcttaaaaa 178140 aaaaaaaaaa aaaaaaaagt agcccatcat ggtggtgtgt gcctgtagtc ctagcttctc 178200 gagaggctga ggctggagga tcgtttcagc ccaggagttc aaagttgcat tgagctatga 178260 ttacaccact gcactccagc ctgggtgaca gagtgagacc ctgtctctgg aaaaacaaaa 178320 aaaggagatg ggggtgggag attgacatct tgtggatcac agataatagc atcaatccaa 178380 aagaggcaga agtttgctaa ttatttgctg aatttagaga agtgtccctc tcacccattt 178440 gcatccttat agacttttct gaaaaagtga cagcacccca gaggtgtccc ataaccatta 178500 gcccgtctta cacactctaa tcccatagcg taagtctggg tgggctaacc ctgaatgatt 178560 acagaccttg acttcccttc agaattttta gggagtttgt cacaatctgg ctgtgtctgt 178620 cggagtagtg aggatcagtc acttggttca taagggctgc aatggagaaa agatcaacac 178680 cccatcttcc tagaatgctt tatattttag aacattaaaa taatagttct agtgctatat 178740 gatatcatac gaagcctagc tttaaacaaa taagatggcc aggcgcggtg gctcacatct 178800 gtaatcccag cactttggga tgccaaagtg ggtggatcac ctgaggtcag gagttcaaga 178860 ccagcctggt caacatggca aaatcccatc tatattaaaa atacaaaaaa attagccggg 178920 catgatggtg ggtgcctgta cttgggaggc tgaggcagga gaatcacttg aacccaagag 178980 gcagaggttg cagtgagcca agaccgcacc attgcactcc agcctgggca acgagagcga 179040 aactctatct gaagaaataa tagaagagaa gagaagaata aaataaaaag taaaataaaa 179100 tagttctgat ggtacatgat accatactaa acctagcttt aaacaaataa gatgaccagg 179160 cacattggtt gacacctgta atctcagcac tttgggtggc caaggcaggc gggtcacttg 179220 agcccagcag ttcgagacca gcctgggcac tctagggaga ccctgtctct aaaaacaaaa 179280 caaaaaacca aaaatttgcc aggtgtggtg gcatgggcct gtagtcgcag ctactcaggc 179340 tgaggcagga ggatcactgg aacttggaag gttgaggcgg cagtgagctg tgatcatgtc 179400 atccacactc cagcctggat ggcagagtaa gaccccatct caaaaaaaca aaatgacaga 179460 aaacatgatt tctgtttcta ttttaaaggg taaaatagta tattttaaca ctttgaaatg 179520 aagagtctgg gcttgggaac gttacaatga tgtttactcg tactagttac gcactcccct 179580 cccagatctg tctcgtaaca agagactgtt attttctact tgtttttagc caaaaggccg 179640 agaaacgatg gttattttaa atccctagtg tctcttacag ttgatgtctt cttagtattt 179700 aggaatttcc aggacatctt tttgttgttg ttaatgcact gtgtgtgtgt gtgtgtgtgt 179760 gtgtgtgtgt gtgattatag gagtgaccca ctacgcccgg ctgtgtgtgt gtgtgtgtgt 179820 gtgtgtgtgt gtgtatgtgt gtgtgtgtga ttataggagt gacccactac gcccggccta 179880 tgtgtatgta ttttaaaggc ttcaatgaga aaaaagttgg ttcttaaaaa ggcaagcttc 179940 agattccagg gaagattgcc tctggagagc tctgttttaa tccatgggtt tgccagatta 180000 atgaggattt actggcctcg tgccttcggc cctccctacc ctgcgcccat tgtgcatgtt 180060 ttgaaaaagc agtgccagga aggactctct ctggaattac tgcggagtta cttgagttag 180120 caaagaatcc ccttcctccc ccaagagctg taagccaagt ctctgtagag ctgactccat 180180 gcctgtttgt ctgcctgtgt gtcttggcgc aggtggctgg ccgtgcggct ggagtgtgtg 180240 ggcaactgca tcgttctgtt tgctgccctg tttgcggtga tctccaggca cagcctcagt 180300 gctggcttgg tgggcctctc agtgtcttac tcattgcagg taagagggga tgctcttggc 180360 tggattatta aagtctgtta atgggggagc cagttgtcct tggctttgga ttccagctcc 180420 aacaggaatg ggggagagga acttgagagg tacggagttt gaggagcagg tacagtgcca 180480 cagtgcctgg tgaccaacta gagcaggaga cggatttgac atgtggccag gattttcccc 180540 atcagtcaca cagattcctt agtggcccaa gaggatactt ccaggtacga ggggaatgct 180600 tttaaagcta tgaatttccc tctaagaact gctttagctg catctcacaa atgatgatac 180660 attgtgtttt catattgtca cctggctaaa aatattttcc agtttcttat tatgtggccc 180720 atgagttatt ttggaaatgt gtgtgcttag gagatggcaa tgtggcaggc ctgggtgatg 180780 gctatacctg gggttgctaa tttcggtacc tttcttacct gaatgtttca taactcataa 180840 ccttttattt ttatttattt attttttttg gagacggaat ctcactctgt cacccaggct 180900 ggaatgcagt ggtgggatct cggctcactg caacctctgc ctcctgggtt caagtgattc 180960 ttctgcctca gcctcccaaa tagctgggtt tacaggtgtg cgtcaccatg cctggctaat 181020 ttttatattt ttagtagtga ctgatggggt ttcgccacat cggccaggct ggtctcaaac 181080 ccctgacctc aggtgatctg accgcctcag cctcccataa ttcatacttg ttgaaaataa 181140 tttgtttcct attatctcag tggaaaaaaa gaaaaaggaa agtcaagtac gcccgcttac 181200 tctagaaatg ccacgtgact cttccactca caggtcacca cgtacttgaa ctggctggtt 181260 cggatgtcat ctgaaatgga aaccaacatc gtggccgtgg agaggctcaa ggagtattca 181320 gagactgaga aggaggtagg caagggcccc tggctggacc tcttggtctt tggtgtagct 181380 ttaccccaag gagatctctg gaccctatcc tgtgcacctc tgcctctgag ctggatacct 181440 caccaggtag aagtgcatct taacgcttgt ccagtctttt tgcagcactt atttagagcc 181500 cggttttagg gtgaaaatag tttaccggct ttacccaaga tctggggtat ccatatacga 181560 gactgtggga tgctgtcagg gcattcagaa ggtattcaca ttgtgaagaa gtttccccct 181620 ctatttctct ttcataactt ctgatggtat cacagagaaa gtcttagtct ggggctagca 181680 ggtctttaac accttagcaa ttgagatgat ctcccttcaa cagacagata aacagcagcc 181740 ctcacacttg gagtcttcaa caggacggat tctgtctatc agaaataacc ttctgttatt 181800 tgttatgaat ttggtttttt tgtgtgtgtg atggagtctc actgtcaccc aggctggagt 181860 gcagtggcac aatctcggct cactgcaacc tcctcctccc aggttcaagt aattctcctg 181920 cctcagcctc ccaaatagtt gggattacag gtgcctgtca tcatgcctgg ctaatttttg 181980 tatttttagt agagatgggg gtttcactaa gttggccagt ctggtctcaa actcttgacc 182040 tcaggtgatc cgcctgcctc agcctcccaa agtgctggga ttacaggcgt gagccactgc 182100 gcctggcctg ttatgtattt gtatagggga ctcctgttac ggaaaataat actacttttc 182160 cttttgtgat tgtaataaat tttcctctta agtaagttga gaaattaagt ctaagtgact 182220 tgattaagca tattaaaaca acaagagaat gagtacatgc atactacacg aatgatgtag 182280 ctgggaactg accaaagttt gggaaaccct gccgttattg aaccccagtc ccctttttat 182340 agatggagaa aaagggaacc tggggaggga caacagctga tccaaggtcc cacgtggctt 182400 ggtagaacag ctgggactag gacccgtgcc tccagtcttt gatgttgcgt tgcccttaat 182460 aactgccttc ttaggccctg aacagcagca caagtaggaa cagcagtgat aatagataat 182520 cacaataatg cctggcgaca cccccaccct acattaatga taacagggac acacatagtg 182580 ccttgtagaa tgtcaggccc agacttaaac gtttaatata gagtaatgca ctcagtcttt 182640 accccgctct atgactgatt tttgagacac ggtctcactc ttgcccgggt tggagtgtag 182700 tgcgatctca ttcgctgcct cccaggctca agtgattctc ctacctctgc ctcctgagtg 182760 tctgggacca cgggcatatg ccatcacacc ggactgattt ttgtattttt agtagagacg 182820 ggattttgcc cagactcatc ttgatctcct gagctctagt gatctgcctg ccttggcctc 182880 ccaaagtgct gggattacaa gcgggagcca ccatgcccag cccagcccta taatttagat 182940 gctactatta cccccatttt acaggtgagg aaactgagac aaaaagctga agttacttgc 183000 ccaagatcac atggctggta aatggcagac ctaggcgttg agcctgtgcc tcctcagaga 183060 ccctatccag tgccatggga gtcatgctac ccggcctcct gaggagagat gccccttggg 183120 agtgagacca aggcctctgt aaggtctgtc ctcctgagga attcacagag gtgacctcgg 183180 cccactcctt taacattctg actgggtgaa ccaggtccca tgtcacgggt gagcattgta 183240 agaatggcgt gagtgccccc gtgaggaacc aagggtgtat tacaccggcg gcttccaact 183300 tgacactgaa tttaattcac ttacaaggta tttcattagg tttttttttt tttttttttt 183360 agatggaatt tggctttttt tttgcccagg ctggaatgca gtggcacgat ctcagctcac 183420 tgcaacctcc acctcctggg ttcaagtgat tctcctgcct cagcctccca attagctggg 183480 attacaagta cccaccaccc cgcccagcta acttatttca ttagttttta taatagcctc 183540 attgacatgt gaatttcaca tgccatggaa ttcacccagt taaagcgttc agttagattg 183600 aattcagttt tttttttgtt tgtttgagac ttaagtctcg ctccagcctg gagtgcagtg 183660 gcatgatctc agctcactgc aacctccttc tcctgggttc aagcgattcc cagcctcctg 183720 agtagctggg attacaggcg atttttgtat ttttagtaga gaagggattt caccatgttg 183780 gcccggctgg tctcgaactc ctgacctcgt gatccacccg cctcagcctc ccaaagtgct 183840 gggatcacag gtgtgagcca ccacacccgg cctgagttca gtttttaaaa gcattttact 183900 tttgactgac ttttatattt ttagaaggat cgtgtttgac aaacccaaga gaaagtaatt 183960 gtcctcatta gtcctaccac tattctgtat ttgcatgtat ttttatatat agatagaaag 184020 ttccacatac ttctctccat tccgctcact gtgttgttat agcatctccc cttcaattat 184080 gtacataaat tataaaatag agatacactt gttgttttaa aaaagaaaaa atcaatacag 184140 ggctggacac agtggcccac gcctgcaatc ccagcacttt gagaggccaa ggtgggtgga 184200 tcacttgaag ccaggagttc gagaccagcc tggccaacgg tgaatcccgt ctctactaaa 184260 aatacaaaaa ttagttggca tggtggcagg tgcctataat tccagctact tgggaggctg 184320 aggtgggagg atcgctggaa cccgggaggt ggaggttgca gtgagctgaa gaaacatcac 184380 tgcactccag cctgggtgac agagtgagac tctgtctcga aaaacaaaaa aacaaagaag 184440 tttatggtgg agaaagacag tttgttcctg ttcgccccgt tcctctcctc tccagagaga 184500 ggccccatta gcattcgggt gaatttcccc caaaactttc ccgtgtggat tcccacatac 184560 cccaacactt ttgtttgctt gtttcttttt cttttaacgt aagtggaatc tacctgttat 184620 cctgtgaaac cttttcttta accatgaggc acctttgcat ctgtgtatag taacagtcac 184680 tgcctctaag ggctgctgtg aggctcagat gagatcatgg gtctcaagtg ctgagcagag 184740 caacttgcct tagttgcatt gtaagcgctc aataataaca tttatttttt ggccaggcgc 184800 ggtggctcac gcctgtaatc ccagcacttt gggaggccaa ggcagatgga tcacttgagc 184860 ccaggagttt gagacgatcc tgggcaacat ggtgagacat cgtctctaca aaataaaaaa 184920 taatactttt tgttgttggc ggtggtggtg gggttttttt ttgttttttt ttttttgaga 184980 cagaggagtc ttgctgtgtc acccagactg gagtgtagtg gttttatctt ggctcactgc 185040 aacctctgcc tcccagattc tagtgatcgt cgtgtctcaa cctcccaagt agctgagatt 185100 acaggctccc accatcaggc ccagctaatt tttgtatttt tagtagagcc agggtttcac 185160 catgttggtc aggctggtct caaactcctg acctcaagtg ttctgcccac ctcggcctcc 185220 ctaagtgctg ggattacagg tgtgagccac tgcgccggca acgctgtgat tttatagcac 185280 gtccacaaaa gggctgcatg tcttgcctaa aagttgcccg gcgttttctt gttatgtgcc 185340 gtctgcagtg cccctgagct tggccatgtg ctctgcagcc tggttcagca cctgtgtgtg 185400 ccctggacgg ggaggtgcat tccccgaggc taaaaccagt gaacctggcc caggccatat 185460 ccagctgtgg gcctcaggaa atgctgaact gaactacttt tcaaaaggag ggttgtgtgt 185520 ccctgggcaa gttaccgccc ctctctgtgt ctcagtctcc ttgtgtgtaa actggggata 185580 atgaaaggac cctcccacat ggggttgctg tgaggattgg atgagacact gcgatacaga 185640 tgctgctttt atccttgcct tcctgccggg gtgggcagcc agggtaactc acttttattg 185700 tcgtgtctgt ccagagaaga ccactcattt cattgactcc atttataaat atttatttaa 185760 attttttttt atcaaaaagt aagttttatt ggcatctaaa aacaaaattc acccaacact 185820 gaaacatact tcaatattta tgttattgtt ttcttgtttc ttttttactc actgcagtgt 185880 gaggaacaaa tcacatttac tttggagaaa cagagaccat agtgtagatt ttacaaaatc 185940 actttttaaa ctctctgtat tgcgctcctc aaatacctag agccagtctg tgcataacat 186000 ggcacactgt tgtctaaacc gtaaaatttt gcatcagcct aaagatatgg ataagatata 186060 cctccacttg ctcttttgaa atacatctat taccttatcc agcctaatga tagttaccta 186120 aaaaattctt tgttccgtag gaagtctctg acaagctgtt attcatttcc ttgacgttaa 186180 aagaatctgg gggcaacatt tatattttat cagaaaaact ttttaaaagt ttacctatca 186240 tgttcatatt gagaacaatg tctgtggcgg gcatggtggc tcacgcctgt aatcccagca 186300 ctttgggagg tagaggtggg tggatcatga ggtcaggagt tagagaccag cctggccaac 186360 atggtgaaac cacatctcta ctaaaaatac aaaaattagc tgggtgtggt ggcgggtgtc 186420 tgtaatccca gctactcagg aggctgaggc aggagagtcg cttgaacctg ggaggcaggg 186480 gttgcagtga gctgagatca tgccattgca ctccagcctg ggcgacagag tgagactcca 186540 tctcaaaaaa aaaagaacaa tgtctataca aatcagttgt acaattattt taaaagaatg 186600 gtgagcatga acgtcacgtt aattctggca gacaaaaatg aacaactatg gtccattgag 186660 ccattatctg ttacacagag atgacagctt tacagaaggt atctctgacc tactgaggga 186720 tgatcatgtc ctctcagttt ctgtgccttc taccactagt tcactttcta tatcagcagc 186780 tgtgtcactc ttcttgttta tgttcataaa tgtgtgttga acacctacta tgtgctctga 186840 gccctgggat acagcagtga acaattagag cctgtcctca ttgagtggat ggtgcagtgg 186900 gtgtgggaga cagaatacac tcaagcatgc gagccccaag agggctgggg acaggcagtg 186960 ccctgaagga gaaggcagtg cgggagggga cagagggaca cagggctgag agggtgctct 187020 gtatcgacca gagatccaca ggatgcaagg gggtcatttg gggaataaca ttccaggaag 187080 ggcaaccccc cagtgctgag gcctgggagg ccaccttggg cagcagagtg agtgagaggg 187140 gaggtcaggg gagtcacagc tttaccagat ggactggaaa ttccttactc tctcccttca 187200 ctgcgatcga aggcgccctg gcaaatccag gagacagctc cgcccagcag ctggccccag 187260 gtgggccgag tggaattccg gaactactgc ctgcgctacc gagaggacct ggacttcgtt 187320 ctcaggcaca tcaatgtcac gatcaatggg ggagaaaagg tgggtacaca tcgccccatt 187380 ccctcaccca ttcccagtcg ggcacagggt gccatcgggc aggtgaacct agctgcagcg 187440 tctccccagt cactcacggc tccacacctt tgcttgaatg gctttttggg gggctgggag 187500 tggactgtgg cagtaaaagc tgttcagagc gcatacagct tgcagaagtg aaggctttta 187560 ggtgaactga cagcctgaag accaaatgag ccccacagat ttgttttgga agattttttg 187620 ttgttgttgt tgagagaggg tcttgctctg ttacccaggc tagagtgcag tggtgtgatc 187680 tcagcccact gcagcggcag cctcccaagt ggggggacta cacatggttg ggagtgcagg 187740 tgtgtgccac tgcacctggc taatttttgt attttttgta gagatggggg tcctactatg 187800 ttgtccaggc tgatctggaa ctcttgagct caaccggtct gcccgcctca gcttcccaaa 187860 gtgctgggat tacaggaatc agccaccatt cctggcccct ggaagaagtt ctttttttgt 187920 tttttggttg gttgtttttt tttttttttt tttttttttt tttgagatgg agtcttactc 187980 tgttgccaag gccagagtgc aggggcccga tctcagctca ctgcaacttc tgcctcctgg 188040 gttcaagtga ttctcctgcc ttagcctccc gagtagctgg gactacaggc atgcgccacc 188100 atgcctagct aatttttgtg ttattagtag agatggggtt ttgccatgtt ggccagggtg 188160 gtcttgaact cctgacctca actgatccac ccgcctcagc ctccccaagt gctgggatta 188220 caggtgtgag ccactgcacc tggcctggaa gaaatttgaa taagttgcaa atactgaaaa 188280 atctggaaga cttaatataa aaatttattt tctgcttttt ttggaagatc agaacatctg 188340 gcaacatcag gtcaatcctc ccccgcctgg ctctttctag tcaacctgtg agcctcctgg 188400 ttcaccccag tccctccctg tcccattcat tgcctagttg gcccctccaa aacattagaa 188460 tttgtgatct ctagaataag gtgtcaccat cccttctagg gggatggctc aagggaagtg 188520 agaaattgtc agaattttgg aaccttctct tggttccgag ctgttcttgg aagaggttcc 188580 ttgacctgag tgataccctt agactttcct ctggaattgg tctgacagtc ttcctggcca 188640 tttgctgggg gacaaggctg ctttcacctc tgaacatatg gacttattga actgttccta 188700 cgtacctccc acaaagctca gaacattctg ttcccagcag ataatttctc tctgagttac 188760 agagaagagc agagtgggtg atgttcttgc tgtctttttt tgtttttgtt tttgtttttg 188820 tttttgtttt gttttgtttt gttttgagac agcctctcac tctgtcaccc aggctggagt 188880 ccagtggtgc tatttcggct cactgcaacc tccgtcccct gggttcaagt gattctcctg 188940 cctccgtctc ccgagtatct gggactacag gtgcatgcca ccacgcccag ctaatttttg 189000 tagttttagt agagatgggg ttttaccatg ttggccaggc tggtctcgaa ctcctgacct 189060 tctctgatcc accttcctcg gcctcccaaa gtgctgggac tacaggcatg agccaccgtg 189120 ccccagccct tgttgagtct ttatggctta tctcacgtca tgagaatttt tgcacgcatg 189180 ctgctctgtg acacccctgt aggagggaag aaggagccca cttctcaaga gccaggcagg 189240 aaggggagaa ctggaggtca ggaacatcat cctttggcca ttagctagag aacctagttc 189300 cttcaagaga ggatgcatgg agaccaggtc atagcaaagg gccggaagat ctgcctgaat 189360 ctttcagata tttcaacaac tcatgatggg aaactcacca tcaaaggtgt gaaaaacagt 189420 ggggaaatga ggaaatgcct gattattact taatagtttc ttgagtctaa acaaataggg 189480 ctttgttgga aattccttct gcctcttctg tatctctttt gaggtctcta gtaacttata 189540 aaaagccgag tcattccttt tgggagcctg gcaaagggaa gagagtcctt cttgaccttc 189600 ggccgaaaca cccttaaagg agtgtctctg ggcagcgcgc aagggagagg gctgtcgagt 189660 tgggttgacc agatgactga tgcctgaggt ggggccgaga tgagggcact ttggggcagg 189720 gacaagtccg gatgccagca ttcccaccac acctgggccc ttctgtcctg caggtcggca 189780 tcgtggggcg gacgggagct gggaagtcgt ccctgaccct gggcttattt cggatcaacg 189840 agtctgccga aggagagatc atcatcgatg gcatcaacat cgccaagatc ggcctgcacg 189900 acctccgctt caagatcacc atcatccccc aggtggggtc tgggtgtggc ccagggggtg 189960 agccagagct ggcaagccct atgattgcac tgacagtggt gtatgtatat ttttggggca 190020 aacatacatt tggccctact tcatcgttct tttttttttt tttttttttt tttttcctga 190080 aacagggtct cgctctgttg cccagagtgg agtgcgctgg cgcaatctca gctcactgca 190140 acctccgtct cccaggctca agcgattctc ccaccccagc ctcctgagta gctgggacta 190200 caggcacatg ccaccacacc cagctaaatt tgttttgtac ttttttgtgg agatggggtt 190260 ccactgtgtt gcccaggctg cccttgaact cctgggctca agcaatccac ccaccttggc 190320 ctccaaaagt gctgggatta caggcatgag gcaccgtggc tggccttcat tgtttttatt 190380 gaagttaggc tgtgctgctg cttccctgaa tttcctctta gtatatgatt aacaacgtgg 190440 gaattaactg actatcagtc ccgacttcct gtccccggga ggggtagttt cagagcatct 190500 agaaaaatcc aaaaagacac cgtcttctct ctctgctgcc agagtcagac tgagcatctc 190560 taacccttcc aagagctaga caagaaataa gactttttaa ttttcgattc acggggtgca 190620 cctgcaggct tgttacgtgg gtatattgtg tgatgctgat gcttcggctt ctatggatct 190680 catcacccaa ctattgaaca gagtacccga gagagagtag tttctcaacc attaccctcc 190740 tccatctgtc cccacttatg gaggctccag tgtctatcat ttccatcttt acaaccatga 190800 gtacccagag tttagctccc tcttacaagt gagaacacac agtatttggt gagaaataag 190860 gattttcttt ttctttctct tttctttttt ttcttttttt aactgagacg gagtctcact 190920 ctgtcaccca gtgcagtggc acgatctcag cttactgcaa cctgcacctc ctgggttcaa 190980 gcgattcttc tgcctcagct tcccaagtag ctgggattat aggcacgcac caccatgcgt 191040 ggctagtttt tgtattttta gtagaaacgg ggtttcacca tgttacccag gctggtctca 191100 aactcctgac ctcgagtgat ctgcctgcct cggcctccca tagtgctggg attacagggg 191160 tgagccaaca tgcttggctg aaataaggat tttctagacc aatccccgca ggtggattcc 191220 ttaatatgtt gccttttagt gtaatcttcc ctaaagtgtc ttagaagatt ctcttctgtg 191280 gttggatgac gggagaatcc acgggacttt actgttagga atcacctgtg ctgcgtctca 191340 tttctggagg ttctcaaccc acttgcatat tgaaggctcc aggaagttgt atggaaagga 191400 aatctgttgt attctgccaa actcagactt tccagacttt tttttttttt tccattatta 191460 aggcaatttt ttttttggag atagagtctt gctctggagt gcagtggcac aatcttggct 191520 cactgcaact tccgtctccc gggttcaagt gattctcctg cctcagtctc ctgagtagct 191580 gggactacag gtatgcacca ccatgcccag ctaatttttg tatttttact agagacaggg 191640 tgttgccatg ttggccaggc tggtctcgaa ctcctgacct taagtgatcc actcgcctcg 191700 gcctgccaaa gtgctgggat tacaggcgtg aaccaccgta cctggccttt ttctccatta 191760 ttaacatctc cagaaatagt gattccaagg agctctgata ccccaccttc aacagtcctg 191820 gccagaagtc cttaggtcgc ctccatccat gtcagcgtga cacaggtgtc acatgccgtc 191880 cactctcttc tctctgaaca ggaccctgtt ttgttttcgg gttccctccg aatgaacctg 191940 gacccattca gccagtactc ggatgaagaa gtctggacgt ccctggagct ggcccacctg 192000 aaggacttcg tgtcagccct tcctgacaag ctagaccatg aatgtgcaga aggcggggag 192060 aacctcaggt aggcgggggt gaacaaggag acaccgggta aggtgtccta ggcgccatct 192120 cggtaggggt gtttgaagat tctgtccaga tctgtgtcac ctggatttga gtcccagatg 192180 accatttgtc ccttcacctc ttggagcctc agtttctgta tctgtaaaac gggtctcaat 192240 ccaggctctt tgtaccatga ggtagaataa ccaggatgac cagtacattt ccttttatac 192300 acaccagctc cattcagttg atagtggctg tcagttgtta agctatggaa agtcttctgt 192360 accagttggt cactagcact gctctgagcc cccaggtccc catgcactac cccagctgtc 192420 ttggtctcta ccaggatcct ggagctctgt ccatgaccca gcaactaaag cattaatgcc 192480 tggcacacca gcggaacctc tggggtcctg ctttggtggt gtttgttagt gcctggttct 192540 ggttctgtta tccgtctcca tgacaaccaa ccataaagcc tcaggcatgt tcaaccataa 192600 agcaacgatc attgctgcca tacgagggca gtcagccagg tggctctgct gatctcggct 192660 gggctcacat gcatgtctgg gagtcagctg gctgttggct gatctcgggg tcagctggct 192720 tttggcctca ggtggggcaa gaagggtatg ttccgtgcat ccctcattct ccagcagacc 192780 agcttgggca tgttgtcatg gcgatggcag gggcacaaga gcgtgcaagc ccctattgca 192840 tctaacagta ttcttttggc tgtccttact tttgctggtg tcccattggc caaagcaagg 192900 aacatgtctg attccagagc cacctctcat ggccccacag ttggataagg gatgcatggg 192960 tatgaggcct tttttttttt tttttttttt tttttttgag acggagggtc tcactctatc 193020 acccaggctg gagtgcagtg gcgcaatctc atctgcaacc tccgccccca ggctcaagca 193080 attgttctgc ctctgcctcc taagtagctg ggatgacagg tgcctgtcac catgcccagt 193140 taaattttgc atttttagta gagatggggt atcaccacat tgtccaggct agtctcaaac 193200 tcctggcctc aagcgatcca cccgccttag cctcacaagg tgctgggata ctaggtgtga 193260 gccactgtgc ccggctctta tttttttttt attttatttt ttttaagaga cagtgtctca 193320 ctctgttgcc taggctggag tacagtggat tgatctcgga ctctaactcc tggactcaag 193380 caatcctgcc tcagcctccc agtaactggg actacaagag catgccacca cacccagcta 193440 atttgtttat ttttgttttt ggagagatgg gggtcttgct tttttgccca ggctggtctc 193500 aaattcctgg cttcaagcta tcctcccacc tcagcctccc aaagtgctca gattgtaggt 193560 gtgagctgct gttttgagaa tgattctgaa cctgcatctt gctgaatagg agatgtgctc 193620 tgattgatta gtgatgtctg ctgcagacac agatgttggg agtggacatg ctttcctggt 193680 caagcaacat agagtgtctc ctttcgcttc tcccagcctg ggcctaggtt cagggtcagg 193740 ggtggtttga cccaacacta tctcctggtt tttttcttcc ggtcaagtgt cgggcagcgc 193800 cagcttgtgt gcctagcccg ggccctgctg aggaagacga agatccttgt gttggatgag 193860 gccacggcag ccgtggacct ggaaacggac gacctcatcc agtccaccat ccggacacag 193920 ttcgaggact gcaccgtcct caccatcgcc caccggctca acaccatcat ggactacaca 193980 aggtgatgcc actggcacag tggcctctag gctttgggag tttgccttac tcactggctc 194040 actcattaat tcattaattc attcaacact gtccttatcc ctagtgacag ccccagtggg 194100 tggatcctct cttcatcctg gatggtacca gctatttctt tttttttttt tttttttgag 194160 acagagtctc gcttcatctc tggagtgcag tggtgtgatc tcggctcact gcaacctctg 194220 cctctggggt tcaagcattt ctcctgcctc agactcccga atagctggaa ctacaggaat 194280 gtgccaccac gcccatctaa cttttatatt tttagtagtg acagggtttt gccatgttgg 194340 ccaggctggt ctcgaactcc tgacctcagg cgatctgccc gcctccgcct cccaaattgc 194400 tgggattaca ggcatgaacc gctgtgccca gtggtaccag gtatttctaa tatcatctag 194460 tcattcattc acgtcagcgc acctgcggtg ttcccagaca ctggggactc tgtaggctgc 194520 tgtcagacaa agtccctgcc tccaggacca agtagcttat tagatggagg agacaaaaaa 194580 tatacagagc aataaaccaa caggattcca gagggcagca ggtgctggga aggacgcttg 194640 ccaaggagac gggatagcga gtgctgggca gggccactgt ttccattgaa cactgcaggc 194700 ccagtgcgtg gggcccacaa aaaggtttta ttttttttaa aaaatcagaa gcaggccagg 194760 tgcggtggct cacggctgta atcccagcac tttgggaggc cgaggcaggc agatcacctg 194820 aggtcgatag tttgagacca gcttggccaa cacggtgaga ccctgtcacc attaaaaata 194880 caaaaagtag ccaagtgtgg tggtgcgtgc ccataatccc aggtacttgg gaggctgagg 194940 aaggagaatt gcttgaacct gggaggtgga ggttgcagtg agctgagatt gtgccactgc 195000 agtccagcct gggcaacaga gtgagactcc atctcaaaaa aaaaaaaaaa aaaaaaaaga 195060 atataatcca acctggattt tatttatact aacacagtca taaaatagaa tttctagcat 195120 tttgtgtgga gaaagccacc tccgtaggca tcagtgccgg ggaccacaaa agtcagaatg 195180 ctgccatagt gccagggtcc tggggggttt tgagttttgt gtgggtcatc tctgaagagg 195240 tgacatttta gctgagacct gaacaatgaa aaggagtcag ccttgagaag atctgggaca 195300 gcgatctgca accttgttct taagggccgg ggtagtttca gctttgtggg ccacatggcc 195360 tctcagccac ttgactccag tgttgccgtg tgaaagcagt catagatagt gcacgaatga 195420 atgagcatgg ctatgttcca ataaaacttt attcataaaa acaggcaagg ggtcagattt 195480 ggcctgcagg ccacagtttg ccaaccttgg atctaaagga agaacattct aggcagccgg 195540 tacagccgaa tgtaaaaatg aatgcgctta atgaatttga aggctagcat gaggaggcca 195600 tgtacctaga ggttggaatt gagtggacag gggcaggaga ttaggccaga aaggtaggca 195660 ggggctggat cttagagcac catgtaacca cggtgagaag cttggaactt actctaagag 195720 ccctataaag ccattggaag gttttaagca gggaagtgac atgagtttct attttatttt 195780 atatattttt gagacagggt ctcaccctgt cgcccaggct ggagtgcagt ggtgggatca 195840 cagctcactg cggcctcaag tgatcctcct gcctcagcct tccaaagtgc tgggattata 195900 ggcgtgagtc tctgcaccca gctgacatga tgtttctagt tcactgagta ccacctacta 195960 agtggcagat gctgagttgg tgcttttgaa atataggaca tagaaatgag gacagaagtg 196020 ggcagtgtca aatcttacag gacctaaaat attaggggtc agccaactat ggcccacagg 196080 ccacagatct ggccccctgc gtgtttttat gaataaagtt ttattggcac gcagccacat 196140 ctgttcattt tcctgttgtc tctggcagct ttcacactat aaatacagca gagatgcgta 196200 gttgtaacag aaagcatatg gcctgcagag cctcaagtat ttactatctg gcctttttca 196260 gaaaaatgtt gccaatcgtt attgtagact gtggtaagat ctttttattt tactctgaat 196320 gtaatggaac agtgaatgtg aacagtcaac actgttaata ccattcacac catgattgat 196380 gtggggtaga tattaaggag ctggcctcat gggaatctga cattgactag aaatagggat 196440 tgagggtgag caaccagctg gaaggtactg caccagtcct agcaaaaagt gttaggggcc 196500 tgacccgaag cagtgacttg cccaggtcag ttgtcccagg ggcacgaggt gctcacccct 196560 ccccttcccc tcatgtctgt atcccctctc cctcagggtg atcgtcttgg acaaaggaga 196620 aatccaggag tacggcgccc catcggacct cctgcagcag agaggtcttt tctacagcat 196680 ggccaaagac gccggcttgg tgtgagcccc agagctggca tatctggtca gaactgcagg 196740 gcctatatgc cagcgcccag ggaggagtca gtacccctgg taaaccaagc ctcccacact 196800 gaaaccaaaa cataaaaacc aaacccagac aaccaaaaca tattcaaagc agcagccacc 196860 gccatccggt cccctgcctg gaactggctg tgaagaccca ggagagacag agatgcgaac 196920 cacccaaaac acgcacaccc tgcccctggt gccctgagac agacacacag cctcacgccc 196980 ccaggaatgc aagtggtttc ctggtgcttc ccacggagga gttttggcag ccagacttct 197040 ggaggaattg gttgtataga agatcctagt gaccaaattc agcctactgc ctcggatctc 197100 tccagccgaa gtctgtggac tgcaagtctt tgagatgctt ctggctccca tcacctctaa 197160 catccttgtc tgggtctacc aggaacgctt catttccttg gggctgcagt tttgtggttg 197220 aggggcctgg agaaaatcat tttctcccct tggcagtgtc ccagggccct ggatggtcct 197280 cttaccaaca tctggtcttc caggcactca aaagctggga accagcatct cagcgccagc 197340 tctaccagtt ctcgttttgg gccagaggca gcctctgcac tcccacgcct gtcctcctgg 197400 aagggacctg gttggactaa cggctaacct ggacctggaa ctgtagggcc aggggattgt 197460 ctcagggccg acgttccacc tggggcttcc ctccccaccc accccgactc caggctttcc 197520 cttttttctt ttgttcaaca ttgtaagaac aatcaatgct gttattactg ttcccaccat 197580 gattgatgtg gggtaaatat taaggagatg gcctcatggg aatttgacct tgactagaaa 197640 tagagactga gagtgagcaa ccagctggaa ggtactatgc cagtcctagc agaaaaatgt 197700 gttaggggcc tggcccaaag cagtgttggt tgcttacagt gttgattgat tttgttcttt 197760 tttcttacca cctcttttct ttccctctca tggtacctgc tcatggttat gaagctttca 197820 aagtaaagaa cacgaaatac ctcccaagta ttaccagtgg gtaccaaaaa aatgtcccct 197880 tgagtctttt ccttgttttt agatgttaat tctctccctt ggcatccggt tagcccccca 197940 gggggggcag cattgtggag aacttgatat ttagttactg atgctcttcc aggacacgaa 198000 aagaacccat ctttgaatat caatgatttt ttttttttaa gtactgttcc ggggagaaaa 198060 acagtctcaa aacttgaact tcttgggaat agaagtgttg ggctgagaag taacattccc 198120 aggaaatagt gagaagctcg ccctgtgttt gaaaccgtgt tggtctctgt gttcctggaa 198180 gaaaacaggg aagcagcatc ttttaaagcc tgttctttaa ggtgtctcgt tagagcccaa 198240 agtggaatcc ggaaggcagc cagagctgag gctgccccaa gactcagact tgctaagaat 198300 tacgccgccg acttcaaacc cagagagcat ctttctttta ggcgaaaacg catatattta 198360 ttttttgtaa gttataccat tctttcacat tagataaact aagttttggg ggatcctttt 198420 gtaatgactt acactggaaa tgcgaacatt tgcagtaaaa aaatatatat atatctatat 198480 attttatttc tttctaaaga atggttccct ttcctttggg gcctcggcga gggttccagc 198540 catgtcctct gcagggtcag gatgtggcat cttcctgttt ctgttctttc cttttgacaa 198600 caagtcgcct ctagtgggag ctgttgccag aaagggcaag ttgtagagat cactagtcag 198660 atggggttta gtgggaaggc gggacagccg caaggtggac ggagcccagg ttttggggtt 198720 ggacagaccc tggcttgagt cctgctcttg tcatttgctg ttcttgtgac cctggggaag 198780 tcactcagcc tctgtgcctc acttgctttg tctgtaaaat gaggctgatc gtacttaccc 198840 tgtgagcagt gatgtgtgcg gtactcgtag cctcggtcag gttctaagac acaggcgagg 198900 cagaaatcac atgtggccag aacgatcctt gaaaatcctg ccctccccct gccctttttt 198960 tttttttttt ttttgctaga ggcacggtct cactctgttg cccaggctgg tgtgcagtgg 199020 cacgatcata gctcactgca gcctcaaact cctgggctta cgcaatcttc ctgcctcagc 199080 ctcctgggta gctgggacta caggcatgtg cccagctaat ttttaaaaat ttttatagag 199140 tcagggtctt gctatgttac ccaggttgtt cttaaactcc tgggctctgg ggatcctcct 199200 gcctgagcct cccaaagtgc tggggttcag gcacctggcc tgaaaatccc tttatgttag 199260 tccagagagg cgaggctgcg ctgcagtaac aaattcgccg taaaatcttc ggaaatgatc 199320 acaaggcttt atttcttgct cacgcagttc ttggtgaggg tcagctgcct ctccagggta 199380 ggtgacttcc ctgtgacaag tgatccaggc tgtcctggtt ttgtgacatg gcctcccaag 199440 ggttggcctc caggtcccca cagtgggaga agggagagtg gacgactctc acccactctt 199500 ctgtgtctga aaccggaact gacgcagtta atcccactca cagcccattg gccaaaatga 199560 gtcacatggc cccaacccaa ccactgcggg agctgggaaa tggagcggtg cctgtggaag 199620 agaaggattt ctccctttcc taactgatgt ggttctggag ttttggatag cggagtagtc 199680 agactagtgt gttcggtttc taacttcgaa ctgggtgagt ctgggcagta aggaatgtct 199740 gtatttgggg agcacaccat ttctgccaca cctaaaacca tgcaccaagt acatgtgcag 199800 atagaacgtt ctagcactgc cattgttccc tcaagctttc ctgtcccctg attgaaattg 199860 ttggcttgca ctagggactg tggtgtacaa aggtgctcag ggaagagccg gcgaggtggt 199920 gaccattaga atgagtagta gtgtctgggt gcagtgactc atgccccatt gaaactgttg 199980 gcttgcatta gggactgcag agtgtgaagg tgcctagtga aaagccagta aggtcataac 200040 cattagaata ggtagtatca gccagccggg catggtggct catgcctgaa tgatgtcatt 200100 ggcttgcatt aggaaccaca gagtatgaag gtgcccagtg aaaaactggt gacgttgtga 200160 ctattagaat tagcagtatt ggctagacga ggtggctcat gcctgtaatc ccagcacttt 200220 gagaggctga gacaggagga ctgcttgagc tgaagagttc aaaaccagcc taggcaacat 200280 agtggaactc tttctatata aaaacttttt ttttgttaaa ttagaagtag ttgaggctgg 200340 gtgcagtggc tgacgcctgt aatcccagga ctttgggagg ctgaggcggg tggattgcct 200400 gaggtcagga gttcaagacc agcctgatca acatggtgaa accccgtctc tactaaaaac 200460 acaaaaatta gttgggcatg gtggcacatg cctgtagt 200498 <210> 28 <211> 57476 <212> DNA <213> homo sapiens <400> 28 cgggggcagg gagaccggac ccagaggcac tggggtaggg ctcggcaggg cgggtccggg 60 cggagcgcgg ggtgcggagg gcggaggcgg ctccggcgcc cgctctgccc gccgctgggt 120 ccgaccgcgc tcgccttcct tgcagccgcg cctcggcccc atggacgccc tgtgcggttc 180 cggggagctc ggctccaagt tctgggtaag gcgcggggct ccggggtcac tgcgcggggg 240 ccagggtcgg ccggcttcgc ccggtccccg ccgcctgcct tcccgcgggg ccggcaggta 300 tcccgggacg gagcccctga gacggcctgg gcgcccggga gggggcgatg ggctcgggag 360 ggaggttggc tgcgccgccc ggagccgggt cccacgcggt gtcggggacc tgccctgctc 420 tgcccttccc ggctgcagca ctggggagcc cgggaaagtg aggaagagtg cgcggctggg 480 gcgcaaaggc acagtgcgtg gctgggtgag tcggctccat cccagcccct ccgtcgggtg 540 cggaaggggc gtttcgcaat cagccgcggg ttcctgatgg agggtcttcc ctcagcatct 600 gcctcaggtt aggactcggt tgcccacctg ggcatggatt gcccccaggg catccagagc 660 acctgctcaa ccaggtgttt tgggaggccg gctgtgcagt gtcccaccct tcttaggaag 720 gtttcctgcc accttctttt ctctaggtaa gactgaggtc tgagagcagg ccatccccac 780 cactccggac tcagaaggga gaagcagacc ccagtctgga gacaggtgca gggtgtcagg 840 attcctgtag tccaactccc ttctcacaga tggagaaagg gaggcccaga gagaggaagg 900 gacttgccca aagttaccca gttcaatgaa ggcagagctg ggatagaaaa acaggctaca 960 ggccaggtgc agtggttcac gcctgtaatc ccaccctttg ggaggcagag gtgggaggat 1020 cacttcagcc caggagtttt agattactgt gagctatgat cgcaccactg cactgtggcc 1080 tgggcgaaag agtgagaccc tgtctctaaa aaaataaata aataagaaaa gaaaatcaag 1140 cctttggtga ctctcactcc aaatctcttt ctaagacagg ctgctcttca gcctgctgac 1200 tccagcctcc agcacagttc aggtgagcta agtgcataca gcctaggagc tttcttacca 1260 acttgcaaaa cttacttgcc tctatgaggc aagtgatcat gtggtctccg ttttacagag 1320 ggagctcaga ttaaaggtgc ttctctgtgg tcattaaagg ggtgtccagg gcttgtgaat 1380 cccaatctct aagtcttttc ctattttgag tatttgtaca tatatgccct ttgtgtgtgt 1440 acgcacacac gcaggcacgt ggggtgttac ccaagagttc gtgctgtgca cgtgtgtgca 1500 caggtgtata agtctggagc tatgctcttg ggctgtgttt agaatgggct gaaggcgtta 1560 tatggatttt ttgaaacttg gggcaatgga ggtaaaaaaa aaaactgtaa aaaggcatat 1620 ttgggattct ctctttttct gtgggtgacc caaaggttaa tccgagatgg tgcaacttct 1680 ctgccactgc ccttctttcc cagtcccaca ggaacttcat gtattattca gcatggacag 1740 gccacttgcc accagggtcc agaggttgtg cctttgcctc atgagcacac ttcctttcac 1800 tgccctttgg gccaggctgg tatgaccgtg gcaggtttgt ggtgcctggg atgccaaaca 1860 gaaaatcaag agggtagttg tgcccaagct tcaggcacaa gggctcattg ttcctgggta 1920 gcctcctgaa ccctgagagc ttaggactct acagagacag gtctcctgga ccccagagtt 1980 gggaaattca ggactccctt tttgtcccat gttcagacat cctctggctc taccttaaca 2040 tgggattgtg gaatccaaga aagtgggagc ttgggagttt gaagcagcga gtccaacccc 2100 tcagtgtaga gctggggaaa ctgaggccaa gggagtgaag gtcacaggac aatcaaagac 2160 agagtgctgg gctgggaaac cggaccccgg ggctgtggtt acagggttgc cattgcctgg 2220 ctgtgagcct ttgagcctct gggccctctg gcccgcgcac ttctccttga tgctcgtgag 2280 ctatacacac ctcctctgag gatgcaggct cagtgggagt cagctcatct acattatgaa 2340 gccctcgtga gatctctgct tggatacctt aaatggcaaa ctgaccaccc cccttcccac 2400 cccaatctct aaacatcttt cacattctct tctggctcct gaaagctgtt ccaggctgca 2460 cccagtgtgg ctggtgactg gggaaggagc gtggagagag aaaggaggct cccagctcat 2520 cctctgaggg aatgacaggg tttgtacagc tgaaaggaga gagagtctac actggaagct 2580 ggatcctctg ccacagccta attacaaaaa aggcctggag ttctgggctg ttcatttgtg 2640 atgtgctgtg ttgcatctca tttgcatggt gtattattaa ggcacaactc cccctgaacc 2700 tttaccttag gggcctgtgg gtgacccact ttgtgggaag tggttcaggg cagcccggaa 2760 gtacctgaac taggagtgaa aatgcaagga gggggtgggg tgttcaggcc cctctgggcc 2820 gctcatttaa tctaccaaga tgctcagtag ctcatcctta tagcttcagt ttctccacca 2880 gtggaatggg aaataaccca acccctaccc acctcacaag atttttctga tcaaatgaga 2940 cagggaatgt ggaatgattt taagaactaa gaagttttct atgggtggca agttctgaca 3000 ttccccggaa gagggaggag aaagaaaaat ggggttagaa gaaaatgtca gacgtgggaa 3060 gacctgcagg gaaagagctg gtagggctgt cgggccagtg gctcccattt cagctgtttg 3120 ctggggagct gggagctgtt cctggctcag tctgagggta ggagactgga gaggaccatg 3180 ccccttggga catgtgtaca cacatctgtg tactcacaca ccacctgcca ggtgaatgat 3240 ttgtgtgaat ccttctctct ctcacccata tcgactttga agcaggttac caacttccct 3300 gaatgtgcct tgggagtttt tgtggaaata aattccaaaa gagtgaactg tgtaattaaa 3360 ccacctcact actcaggagg ccagaggtgc ctcagaacaa gggaggaggt gggatcctct 3420 gcctgcagga ttcctctctg ttctgaacca cagaggttgg gagcacctgg gtggtgaagg 3480 gagtatgtgg aggaagggcc tggaggtatt taccccccgc cagataaaca cctgttggca 3540 gaattagcct tgatctgaca gccccaggaa gcttagaaat ctgaagatcc tgaccatgaa 3600 agccatccaa agatggcaag gaccgcctga gaagtagtga gctccctgtc actggggggt 3660 atgtaaggac atggttagtg actgcttggc ggagatgctg gagagaggat tcaagccagg 3720 aaagaaggtg gggtcctgag attctgtgac tgggtagagg gaagatgcgg ccagtgggga 3780 ttcattagtt cctcctctga gatttctgga ctcctccttc cctggctctc tccctgctct 3840 acatacggaa tttgcctaga agcagctctt ggtagaggcc tctgggtctc cccttggtta 3900 ggcccacatg ggaaaggtga cctcattgtt cccttagctg tttacccatc ctagggaggg 3960 gcagatccct ggtcccttgg aggctcagct ccctgtgtct cctgctctgt tttagctagc 4020 cccaattctg ctattcacca gctgtgtgac tttgggcaaa tgactcacct tctctgggct 4080 ccagcagggc tgaggtgggc tctggggcct gcttcaggtc tggagttgcc caattttgga 4140 aggatgagcc ttgggcttgg gggcgaaggc tatgcatgat tagggccctt caaagcttag 4200 agctcctggg tatcagggtc tcctctgcct tcttagtagg cagccacaaa aatgtatgag 4260 taatgggcaa ggctcctatg ccaatgtatt ttgactcaca aatgaagaca gtgtcctgca 4320 catccatggg gaagctgagt gggaggtaga cactcctccg cttagcagac accatagctc 4380 accctcccct caggaaccca gtcctccctg caaggccaga gctcccgggg ctcctttcct 4440 ccatctcagc tgctgcaagc aaacccagtg ctggatggct ttgacctctg agctcttggc 4500 ttctggctac ggcatttcat tgcttgtggc ctcaggctgg cttctcctca atcctgctgt 4560 tcccccactt cacctgggcc ttaggtccct gagggccaga gagatacggg gaaggaagtg 4620 agtcagggaa gtggcattca ggagggagct ttgccaagcc cgcctgtagt ccccagacag 4680 ggaaatggtc ttgaaacact gggcaggctt ccagggagga aggacttggc agggatgacc 4740 agctgagcca ccccggagta gggccagagc acccggactg tattcagtcc tctccattgg 4800 ggcaggatcc ctggggagtt gggggtgaaa tgagacctgg tatgccattg ctggggtggc 4860 tgggcccctc cccttcccga actgaagttg tttctgtttc tggtactgcg gtgcagtggt 4920 tggggctggc agggggcagg gtgggatagt gaatgagagc ctaactctag gcttggattt 4980 tggatttctc cttttttttt tttttgtgac agagtcttgc tctgtcgccc aggctgaagt 5040 gcagtagcac aatctcaact cactgcaacc tccacctccc aggttcaagc aatcctcctg 5100 cctcagcctc ccaagtagct gggattacag gtgcacacca ccatgcccgg ctaatttttg 5160 tatttttagt agagacgggg tttcaccatg atggccaggc tggtctcaaa ttcctgacct 5220 caagtcatct gcccacctca gcctcctaaa gtgctgggat tacaggcgtg agccaccgca 5280 ttcagccaga tttctcctaa ctggatattc aggtttctag tcaggggctc ccagaacccc 5340 agctaggcca ctacccaggt gttagccgct ctgctccctc agctctgtga gaataattgc 5400 aaaaagcagg tgatatgaga atgggctgca tggctgaaag gtgatctggg tgcaagtgct 5460 ctatccccag ggtgggacat catgccggag tcctaccagg tgtacaggaa acactaatcc 5520 tgtgggaagg agctgggccc tggaacaaaa ctctctgggt ctaatcccag catcagccct 5580 gggtgtcagc tgtcatgagc gtgaaatgat catcctggcc cacagcagga gctcagtgaa 5640 ccaaagcccc ttccagaagc acattggcca gttgagcccg tgagccatcc ctgcaagggg 5700 ccagcaggcg cagcacaacc agtttttgtt tgtttgtttg ttgtgttgtg ttgtgttttt 5760 gagaaggagt ctcgctctgc caccctggct ggagtgcagt ggcgtgatct cagctcactg 5820 caacctccgc ctcccaggtt caaacaatta tcctgcctca gcctcctgag tagctgggat 5880 tacaggcatg cgccaccatg cctagataat ttttttaaat atttttagta gagacagcgt 5940 ttcgtcatgt tggccaggct ggtcgcagac tcctgacctc aggggaccca ccctcctcgg 6000 cctcccaaag tgctgggatt acagcacagc cagtttttga cccctgcccc caggccttcc 6060 aaaggctgag ggagggtgag tggggatcag cacgtgtcct tgctctctcc acgccttcat 6120 tgctgctgag tcaatggtct tgtctgttca tcccttccct atctgggact tcaggagctg 6180 ccctgcagtg gtggcttcct tctccagtac cacacaggaa tagggaagta atgactcttc 6240 tcatgacaga gactgtcaac aggcctgggg cccccagggc ttgggaagtc cctggcaaag 6300 ctggggcaga gggctccggg gtcctcaccc cccgccccca tcgcctgtat gagtctgcag 6360 tgatttcagc ttcagtgacc atgaagtctg ccatgagggg gcctctgcca cgtggtccat 6420 tctggatgtg ggaccttacc ccttatcagc cccatccagc tgtttaatcg cattattaag 6480 gaagctgttg ttgctgtgga aactgtgtgg gtgatggtgg gggagggggc tgtgggctca 6540 gctctcacct cccagcagtg ctcttcagag cgggaatgag aggagagcct tgagtaggga 6600 tcgtcatcct gccctgcagg gattcaggga gtgttacagg gtccagggaa taaccttcac 6660 tggccctgtc ctcaccttca ttttacacat aactgagttg gagacccttc tgggtgccaa 6720 gaactgtggc cttggtacca gggagagaac actgtgttcc tgggcatgaa gctgcagagg 6780 ctgcggctgg agttggcacc ctccatttat ctattcattt gtttattcat tcttttgttc 6840 aatagatggt tattgagtac cttctctgtg ccaggccctg ctctaagcaa caggaaatac 6900 catcaactgc agaatacaga gctaaagaat ctgtcttcgt ggagcatata ctctagtggg 6960 aagaggcagt aaaacaagaa tcataaaggc caggtgcagt ggctcatgcc tgtaatccca 7020 gcactttggg aggccgaagc aggaggatca cttgagccca gaagttcgag accagtctgg 7080 gccacatagt gggaccccat ctctacaaaa aaattaaaaa attagctggg cgtggtggca 7140 catgcctgta gtcccagcta ctcaggaggc tgaggcagga ggatcgcttg agcccaagag 7200 gtcaagatta cagtggggaa aaaaaaaaaa aaagaacagt tgaatgtggc actgtcatgc 7260 cgttcaacct gtaatttgaa ggtagaatgg acagggtttg ctgagagacc ggatgtggga 7320 tgtgagagaa agagaagaat caggggcaac tccaaggact ctggtctggg aagagagaca 7380 ggaggaagga actgccatcc ccgggccagg caggctagaa aggcagggac ggccaagagc 7440 tcagttctgg acgtgttttg tatgacgtgt cccatagttg atgtcctagc tcagggtctg 7500 gagtgaacca aatagggagt taggggtgag ggcctgtgtg ggcgggtacc ccctgcctcc 7560 tagggagggc cctgcccagg tgggacatgc ttatctcaag gaaaggagcc caggctgaat 7620 gcccttgagg gtcaaagcag ccacccagtt ctcacagccc caaagtcccc tggttgttgc 7680 cacagagcag gtgtctgcga aaccaaaaca cgggcctgac agctggaggc tccatcaccc 7740 gcttccctga gtgttgtccc gttgccatcg aagtgctttg ctgttcattc tccctcacct 7800 tctccccgct gtggggaggt gaccagatgc tgtcatcact cccattactc acaggtggag 7860 actgaggttc aagggcacga aggggctcac caacagttgc atggctcaaa agtggcagaa 7920 gccatcctgg attctccgca tcggggttgg gttcttcctg tggccactcc ccacccgcct 7980 tacagagcca tgccaccggc ctgcaagtgc acacagcgat tcccaccatg tccccacgcc 8040 tgggctcctg tcctcaacat gcacactccc ttgtgagtca atggccccgt gtggcatcac 8100 aaagcctggg tgcctgtccc ggccacacac tgctgggtgt ccttgaacct gttgccaaag 8160 tgggtgtagt ttctcttttg tacactgggc ctaacagtgc ccctcctata tacccctgga 8220 agttgttctg agacaacatc cagataacaa ctaggtaagt gcagtaataa aatgcgggag 8280 aaacattagg ggcctttatt ttcctcactt aactggctgc cagggaaaag caaggaaagg 8340 tcagaggctg gggtgcccca gagaggcccc atgtagatga ggctctggct gggcccagag 8400 aaatgggatg tacactccgg cccagagacc tgaagatctg ggttcagggc agctttggga 8460 caggctatct ggatggcaac taactggagt acctgatcag gcctagaggt gtgtcctgtg 8520 acccagtgtc caggcctggg ccagcatgtc agagactcag caagagtatg tgggtccttg 8580 gctcacattg tttgagcaac tactgaatac tgaataggac tactgaatac tgaatactga 8640 ataggacaag atgtacatgg tacaacttct gcccacctgg gccttcaatg aaatgccccc 8700 aggcagcatg tccctgactg catgcttcac agagcaggga taggcctgcc caacgtgcca 8760 ctgtatctgc agaacccagc ccactgcctg actcaccaag gccctcacca aacattgtca 8820 aggccaagag tgacgctcca gggaagggga tctctctagg aggaagggtg ctcaagatga 8880 agaaggtggg ttttcagcca ggcctgtcac ccctccctgg agtggttagg ttaggatttt 8940 gacaagtggt aaaaagaggg actaggttga gcaagggggt aggagcaaga atctcagagc 9000 agatttagga tgaagtgagt tggctgtggg ggaagggagc aatgggaaag gaggtgggag 9060 gagatgccat ggggggggtc ttgaggacca ggttgggtgc taggatgtgg cttcatgagc 9120 agcaggagtc actgcaggtt tgtgggcatg aggcaagagg cacaaagctg tattttggga 9180 agagccatct cgcaggtggg caggggcact ggagggcaga gggctgcccc agatgggatt 9240 aagaagggaa ggcaggccag gcacagtggc tcacgcctga aatcctggca ctttgggagg 9300 ctgaggcggg cggatcacaa ggtcaggagt tcgagaccag cctgaccaac acggtgaaac 9360 cccgtctcta ctaaaaatac aaaaattagc tgggcgtggt ggcgggcatc tgtaatccca 9420 gctactcagg aggctgaggc aggagaatca tttgaacccg ggaggtggag gttgcagtga 9480 gccaaggtca caccactgca ctccagcctg ggtgacagag ccagactccg tctcaaaaaa 9540 aaaaaaaaaa aaaaaaggaa gaagggaagg caggctgggg aggttgggga aaggaagcag 9600 ggagtgcaga tcactcccct tccatgagtt gttttcttaa gatgctagaa cttggccagg 9660 catggtggct cacccctgta atcccagcac tttgggaggc tgaggctggc agatcacttg 9720 aggtcaggag ttccagacca gcctggccaa catggtgaaa ccccatctct actaataata 9780 caaaatttag ctgggtgtgg tggtgtgcac ctgtggtcct agctacttgg gaggctgaga 9840 caggagaatc acttgaaccc tggaggcaca ggttgcagag agctgagatc gtgccactgc 9900 actccagccg aggtgacaga gtgagactcc gtctcaaaac caaaacaaaa caaaaaccaa 9960 ggccgggtgc agtggctcat gcctgtaatc ccagcacttt gggaggccga ggtgggcaga 10020 tcacaaggtc aggagatcga gaccatcctc gctaacacgg taaaaccccg tctctactaa 10080 aaatacaaaa aattagacgg gcatggtggc gggcgcctgt agtctcagcc aatcaggagg 10140 ctgaggcagg agaatggcgt gaacccggga ggcggagctt gcagtgagcc gagatcacgc 10200 cactgcactc cagcctgggc gacagagcga gactccgtct caaaaacaag caaacaaaaa 10260 aacagaaaac aaaaattagc ctggcgtagt ggcatgtgcc tgtaattcca gctacccagg 10320 aggctgaggt gggagaatcg cttgaaccct ggaggcagag gttgcagtga gccaaggtcg 10380 caccactgca ctccagcctg ggtgacagag cgagacttgg ccttaaaaaa aaaaaaaaaa 10440 gaaagaaatt aaccagccgt ggtggtgcac gcccgtaatc ccagctactc agaaggctga 10500 ggcacgagaa tcacttgaac acgggaggca gaggttgcag taagccaaga ttgtgccact 10560 gccctccagc ctgggcgaca gagcaagatt ccatcaaaaa aaaaaaaaaa aaaaaaaaaa 10620 aaagatggga gaactcagaa ctcaagcata tagattattc aacagttcac atagccagat 10680 agttcaaggc cagctgtggg ctttgaatgc catagtaaaa tgtttgaact ttgccttcta 10740 ggcagtaggg agctactgaa agtttaaagg gatggtatac tattattctt tcattcattt 10800 attcaataaa cgtgtatgtg tgtgtgtgta tttttttttt aagagtccag gtcttgctct 10860 gttgctcagg ctagagtgga gtggcataat catggctcac tgcagcaaca aactcccggg 10920 ctcaagagat cctcccgcct tagcctccat gtaactggga ctacaggtgc ctgtcaccag 10980 accaggctaa tgttttacat ttttgtagag acagcgtctt gctatgttgc ccaggctggt 11040 ctcaaactcc tggcctcaag tgatgctcct gccttggcct ctcaaagcac tgggcaatgt 11100 ccctggtctt caataaatat ttgatttatt taagcaaatc ttttttctga gcacctacta 11160 tgtgctaggc accattctaa gtacttagga tacatagata aataaaataa aggttcttcc 11220 cttcaaagag cttacatgtc agcaagtaaa ggaaaagatg agagaaaata taataaatca 11280 gtaaattata tatcatgtca aaaggtgata ggtgttatag agaaaagaaa aagcggagaa 11340 gggtgggaga attgggaata caggggtggg acacaggtgg cagtattaaa caggatggtc 11400 agggtaggct tcattgagaa agaaagactt caggatgtct gggggaggag tgttccagga 11460 agagagaaga gcaagtgcaa aggccctgag acaggagcag caagtgcatt tagaaacagc 11520 aaggaggcca gtggctggag tgaagcagga aaggcgggga gagggtcatg ggttggggga 11580 agggacattg tgcaggtcta tgcaggctat tgtagggtgt atggagtgaa gatgtcaagt 11640 cagcagttag atatggagct ggagatttgg ggagcaatga gctggagaga tagacttgaa 11700 agtcattggc atatagatgg tacatcatat catcatatga gactgcatgg gattgccaag 11760 aggttgagtg cagataggaa ggaggcagag aagaggaaag gactgagctc caggaccctc 11820 ttgcaccagg caggggaatc agcaaagaga ctgtgatggc atggccagaa aggaagggga 11880 aaaccatgca ggatctggga ccccagggaa tctgaaggga agagaccaga agtctatggc 11940 aattgctcat gaagagatga gggtctggcc aaggggccag gtgggaggaa ccaggtaaga 12000 gatattatca tcccaatgtt acccttaaag aaaccaaggc ccagagaggg gagaggttaa 12060 gaacctgggt caagatcaca cagcttaagt gtgacttctt ctttttattt tttatttttt 12120 tgagacggag tctccctctg tcaccaggct ggagtgcagt ggcacaatct cagctcactg 12180 caacctccgc ctcccgggtt caaacagttc acctgcctca gcctcccgag tagctgggat 12240 tacaggtgcc tgccaccacg cccagctaat ttttgtattt ttagtagaga cgggatttca 12300 ccatgttggt caggctggtc tcgaactcct gacctcgtga tcttcccacc tcagcctccc 12360 aaagagctgg gattacaggt gtaagccatt gtgcccggcc aagtgtgagt tcttttaagc 12420 tgtgtgacct tggccaaggt gcttaacctt tccctgccaa gtctcaaaca cctctttgtc 12480 cagctactat gcttccatca agaatcaata ggacctatgt ccctacaggt gtcagggtag 12540 ctggcagaat ggtgatgccc ttggcagagg caggcaaggc caaaggaagg gctggttctg 12600 gcagggagtg aaggatctta ctttgagagg tattgaatat gaggtggctg cagacagatg 12660 gtgacgccat ctgagaggca gcaggaagta ggcgctgagg ctcaggaggt gatttgagct 12720 gttgatctgg atttgggact cctcaggaca atctgtgaac aatgatgaga gagagcacca 12780 aggaccaagg tctgaacttg ggagctaggg cccatgtcca cagggtgaac tggaaggaag 12840 ataaggagac agcaaggaat gcttgccaag aaaccaggag accaggaaag agtagtttcc 12900 aagagatggg ggaagcccac actgttgcag ggaggtcctg cataaagtct gaaacgggtc 12960 tatttaattc gcccttggag gctgggcatg gtgtctcaca cctgtaatcc cagcactttg 13020 ggaggccaag gcgggtggat gacctgaggt caagagtttg agaaccagcc tggtcaacat 13080 ggcaaaaccc cgtctgtact aaaaatacaa aaattggccg ggcgtggtgg tggaagcctg 13140 taatcccagc tactcgggag gctgaggcag gagaatcacc tgaatcccag aggcggaggt 13200 tgctgtgagc tgagatcaca ccactgcaca ccagcctggg agacagagca agactctgcc 13260 caaaagaaaa aaaaaaattg tagttggaag gacttctggt tctatagggt ggattgaaca 13320 caagacttta tctccagtcc ttcctgattt tccatcaaag tgacagtaag gaataaagaa 13380 tgtaaaccta caaggacaaa gagaagagga gacaacagca gacaagatat taacaccttt 13440 ttggaaagtg agaaacaggt tgaggagtga tcactgacac agcagagaac aactgaaacc 13500 aaaggccatt tggagtctgt aaaagctcgg ggattggagg gctgaaggag gcaaggggaa 13560 gagcagggct gaaagcagcg gctgctagga gaatgcataa ggagagatga aacacccaag 13620 atacttatcc atctcctctc aaagccaggc aaattccagc cacctcacag aagaccagca 13680 gtttattctg tggaattaag taaaagtctg catactgaag gatagaaccc tcagccctca 13740 ctcctaaatt ggtcccagag aaaagacctc cagattcttc cagttgttgg gggagtcttc 13800 cctaaaggac caggttccta cttgatcact ctgcagtgaa gcccaacagc caataagctt 13860 ggtcctcggt actctgtctt cagtagctgt ttcttggtcc ttggtccttg gtactctcac 13920 tcatcattgt tcacagattg ccctgaggag tcccagatcc agtcccaaat ccacctgccc 13980 ccaacacaca gagcagccaa ctctttagtg tcttactcca aaatattgag acagccaagc 14040 cgcaagaatc accacaggtc gggtgcagtg actcacgcct gtaatcccag cactttggga 14100 ggccgaggca ggcggatcac ttgaagtcag gagttcgaga ccagcctggc caacatggca 14160 aaacccctct actaaaaata caaaaattag ctgggcattg tgacacgtgc ctgtaatccc 14220 agctactcgg gaggctgagg caggagaatt tcttgaacct cagaggcaga ggttgcagtg 14280 agctgagatc gtactaccac actccagcct gggcgacaga gggagactcc atctcaaaaa 14340 aaaaaaaaaa aagtcaccac acatttgagg aaaaattctg ttaaaataaa aactttagac 14400 aaattaaatt tagcagagtt tatctgagca aagaacaatt catgaatcag ccagcatcct 14460 gaaccagtag aggttcacag agttttacca cccagcagta tgggcaggca gtattaatgg 14520 acagagaaag gaattgatgt atagaaacag cttgattggc gacagatcag tatttgcctt 14580 atttgggcat ggtgcaatga ggtgtttgcc ttatgtggac atgttctgat gatctggcag 14640 cttgtgattg gctgaaaatt ctgctatatt tggctgagac ttggctgctt attgtaagaa 14700 tatactctca agttacgttg cagtttgttt acatattgaa ttatgctaca gtccactatg 14760 tatggagtca gctttatacc tgggtgacag agtgagactt tgtcaaaaaa agaaggagag 14820 gagaggagag agaggagaga gatgaggggt ggggagggga agggaggaaa ggagaaagga 14880 aggaaggaaa gaaggaaggg agggagggaa gggaaggagg gagggaagaa gggaaagaaa 14940 gaaggaagga aggaaggaag aaagagagag agagaaagga aggaaggaag gaaataggca 15000 acacataaaa taaatttttt taataggatc acaggtcact gtgaacaata gccgttcatt 15060 aaatgacttc ggaggcatat acaaaaagtt acatagttgt agaaaaagct tagctgtttt 15120 aatagcgagt tctcagtttt cttaagtgat caaaaaccta acaaagacag catgaagcac 15180 aggaaattat ctgggtagaa cacagaatct ttgttttcta ggccaactac ctaaagagaa 15240 agaaaaacat tttacaattt cctattatga tcagaccaat aatctaagaa caccatgttg 15300 ttttaatgga gagaaccaaa ttctagtttt gcatcagtgt aattttgata ttaatgctag 15360 ctcttatcgc ccaggctgga gtgcaatggt gcaatctctg cttactgcaa cctccgcctc 15420 ccgggttcaa gtgattctcc tgcctcagcc tctcaagtag ctgggattac aggcgcctgc 15480 caccacaccc ggcttatttt ttgtattttt agtagagatg gggtttcacc atgttggcca 15540 ggctgggctc gaactcctga cctcaagtga tccacccgcc tctgcctccc aaagtcctgg 15600 gattacaggc gtgagccact gcacccggtc gctaactttt attcttaaaa aacttgtaaa 15660 taattacctc ctaatcttaa ccagcttgat cacccataaa atttctttca caagattcat 15720 cttccacaaa cctcctacaa ctcttatatc cattcacttt ttgtcctata ctttcctctt 15780 ctcattttcg aaaaatcagt catttcactt taggacaaaa tttattctct ttttccgtta 15840 tcaaaacaaa acatcctcac gtcttatagc ttttccttag cttcctttgt atatttcttt 15900 ttcatatatt cctttttctt accttccttg tatattttca tatagatttt cccccttatt 15960 gtttctagta attgtagcta catatattaa ttagaattct taaccccggc caggtacagt 16020 ggctcatgcc tgtaatccca gcactttgga gtccgaggta ggcagatcac ttgagggcag 16080 aagttcaaga ccggcctggc tgacatgctg aaaccctgtc tctattaaaa atacaaaaat 16140 tggctgggcg tggtggcggg cacctgtaat cccagctact ggggaggctc aggcaggaga 16200 attacctgaa cccaggaggt ggaggttgca gtgagtcaag attgagccac tgcactccag 16260 cctgggtgac agcgcgagac tccatctcag aaaaaaaaaa aaaaaaaaag aattcttaac 16320 ccttagtgac cttaatttcc atggacatta gaaagtaagc atttgtgaat tgtgtgtcac 16380 accagctgta gattggtaaa tctatgaacc ataatgtcta gaagcatgag ctttctcata 16440 gtacaatttg tcagtgtggc acagaacatg tttctcaatg gtccaaaatg tctttaagtc 16500 tctctgtaaa aataaactgt aaaggaggca aaatttcatt tgtatccctt taggtttttt 16560 gtttgtttgt tttgtgaggc ctgaaaacta aattgttgtt tgtacagatt tccctcctcc 16620 tcaactttct attcttgatg ctaagagtgt taaaaccttc tggtggctga gcgtggtggc 16680 tcacgcctgt aatcctagca ctttgggagg ctgaggcagg tggaacactt gacctcagga 16740 tttcgagacc agcctgggca acatggtgaa accccatctc tacaaaaaat acaaaaatta 16800 gctggatgtg gtagcttgtg tctgtagtcc cagatacttt ggcggggctg aggcgggagg 16860 attgcttgag cccaggaggc agaggttgca gtgagccgag atcttgccac ttgcactcca 16920 gagtaggcga tagagaccct atttcaaaaa agtaataata aaaccttctg gtataggaag 16980 gacatctttt acatgggaat tttatcttac attcatttaa ctcacttatt ttcaacactt 17040 atgcttggat tgcctataaa gatgagataa taaacaacta gtcatcattt tgtttttctt 17100 gctgacaaat tttataatat aaagacaaca taagcttgtt ttaccagtaa acctagatag 17160 gaaatcatgc atctttatga tatttaatcc ccaaaactat gaaaacatgt ctgtttcagt 17220 caaaccaaca atattcttat ttgccaaaga ttacccaagt cagatgagct gcaaaagtat 17280 ttgaggtagt tcttaatttt ctgagagaat acttcattta tacaagcact tatttttctt 17340 aaagccaaca aaatagagct ctttcataat ttaattttgg agcattaaaa ggagataaga 17400 aactatgata cctgtatcat acatacagac ttatataaac ataaacagca acagatctta 17460 cagctttcat ttaaatatct tagccatgtt ccaggtacag taatataaaa ctcctgaatt 17520 tattaaagac tatctggatc caaattgttc ttctggccaa tggaacaaga tttcttgccc 17580 agatgactaa agcttttgaa taagattcgt gaaggagctt ttaagatttt tttgtttgat 17640 ttctgtaagg aacctattat aaagaggcaa ttttttattc atttaatctt ttagatgcct 17700 ctgtgtatca attaaagaat gcatcccatt gcttttgtgg catttttgaa cctttctttt 17760 ctaatgcacc ttgcaagtga acagttttat ctaggtcaaa actttcccac tgtggccact 17820 gtaactctta agttgtcctc agcaaagtta acccattttt ccaaaaatac acatgttcct 17880 cataattgtt gttcatgaag ttagccaccg tcccagaaag tggcgtctca gactctggag 17940 tcccagactc cttagatttg gaggaactca ctttcaaaag gcacctgcct gaggctttta 18000 actggatcca tttcagttaa ttatcagatc tgatttgctc ctggacccag tcctacttga 18060 cccagtctaa gaattgttca aataaacttg gagaacacaa aacacaaatt cctgaagctt 18120 ggaatctgag atagaactca cccatgacct ccagttgcta caagagaaca attggcacag 18180 tgtgccctgt caggtaccct tacttggtca ctaaatgctc ctgagggtca ctggagttct 18240 acttccgatc ccacttctga caccaatctg ttaaaagaaa agctttaggc cgggcacggt 18300 ggctcacgcc tgttatccca gcactttggg aggccgaggt gggtggatca cctgaggtca 18360 ggagttcaag accagcctgg cctacatggt gaaaccccat ctctactaaa aatacaaaaa 18420 ttagtcaggc atggtggtgg gcgcctgtag tccaagctac tcaggaggct aaggcaggag 18480 aattgcttga agctgggagg tggtggttgc agtgaaccga gatcacgcca ttacactcca 18540 gcgtgggggc caagagcgag actgtctcaa aaaaaaaaaa aaaaaaagaa aaagaaaaag 18600 aaaaaggaaa agctttagac aaatttagca gagcttattt gaaaaaataa gcaattcatg 18660 aattcagcag catgctaaac tagtaaagac tcggctgggc gtggtggctc acacctgtaa 18720 tcccagcact ttgggaggct gaggcaggca gatcacctga ggtcaggagt tcaagaccac 18780 cctggctaat atgatgaaac cccatttcta ctaaaaatac aaaaaaatta gctgggcgtg 18840 gaggcacaca cctgtaatcc cagctactca ggaggctgag gcaggagaat ggcttgaacc 18900 tgggaggcag aggttgcagt gagccaagat cacaccattg cactccagcc tgggcaacaa 18960 gagtgaaacg ccatctcaaa agaaaaaaaa aaaaaaccta aaccagtaaa ggctcaaaga 19020 actccaccta accatgtggt caagtagtac ttacagagag aaaaaaagtg acacatagaa 19080 atagcctatt tagaactcgg catttgcttt atctggacag gtctaagcac tttgcagtct 19140 gcgattggct gaaagctcag ttgcaatgat tggctgagac tcagctactt gttacaagaa 19200 actctcatgt taggtttgtt tacatattaa gttgggtttc agttcactat gtaaggaggc 19260 agcttaaggc caaatttaat ctaatttaac acctccagct tgaaagacaa aaccaaacca 19320 aatcaaccaa gaaacagaaa aaagaaaatt caaagatgta tgagcatgca taactttgat 19380 aaaaataaaa ataataatta tttgaattgg caattagaaa atagttatat cctcaggtaa 19440 cagatgtctc taggtggatg agattgtggg tggtttttct tgttgttgat attttctgtg 19500 catctctaaa aaacatctaa tgctttgcaa agaacataag aaacagatta gtacattagt 19560 ggccttggag gaaacaatct cagtaaaaca tgtgtttatt aatgaatgta ttcccccatc 19620 cctttccaaa aaagttcata ggtgtagtta tagtcaaagg taagaggcag tcttgtcaga 19680 gccagtaaag taaccaacca tcctggtttg cccaagacca agcagcttcc caagacacta 19740 gactttcagt gctaaaacca gagaagtccc atccatacta ggagagttga tcactctagt 19800 ctgtgtaatt tgcaaagact ctccatatcc tttggttcct gtgagtctca aatccaccca 19860 gtgaggtaca ggtgggccgg tggatggtca cctccatttc agaagagagg cagctaaggc 19920 tcagggaatc tccctatccc tgacccggga aaggccttaa gagaaagtgg tcttttaaac 19980 tgtgtgtata tatcactttg ataaaattaa aaattagttt taaagaagag agagggccag 20040 gcgcagtggc tcacgcctgt aatcccagca ctttcggagg ccgaggcggg caggtcgtaa 20100 ggtcaagaga tcgagaccat cctggctaac acaggtgaaa ctccatctct attaaaaata 20160 caaaaaaaaa aaaattagcc gggcgtagtg gtgggcacct gtagtcccag ctactccaga 20220 ggctgaggca ggagaatggc gtgaacctgg gaggcggagt tttcagtgag ccgagattgc 20280 gccactgcac tccagcctgg gcgacagagt gagactccat ctcaaaaaaa aaaaaaaaaa 20340 aaagagtgag ggccaggcgc agccgtcacg cctgtaatcc cagcactttc ggaggccgat 20400 gcgggcagat cacgaggtca agagatcgag accatcctgg ccaacatggt gaaaccccgt 20460 ctctactaaa aatacaaaaa ttagccaggc gtggtggtgg gcgcctgtag tcccagctac 20520 tcaggaggct gaggcaggag aatcgcttga acccgggagg cagaggttgc agtgagccaa 20580 gatggcaaca ctgcactcca gcctggcaac agagtgagac tctgtctcaa aaaaaaaaaa 20640 aaaaacaaaa acaaaaaaaa aagagtggga atccagaatg atagaaagaa aatgagcctg 20700 ggagggatga actgcagagg accataaggt aacatgggag cagttttgca ggtgtataca 20760 actgtcaaaa ctcactgatt gtacacttta attgggtgca gtttttgttg cccttaaatt 20820 atgcctcaat tagagagaaa gagagagaat ataaggaaat gggggcagcc atggcgtcct 20880 tggagaattc acacttggga cgacaactgc tcatttgtgt actctctcct cctcacctgt 20940 cttccactcc acccctgtct ctgatggaac atctctccag ctaagccatc ttcctcaagg 21000 cagcccaatt ctctgtgggg ctgccacagc actaaactgt tctctgtgtc cccaggactc 21060 caacctgtct gtgcacacag aaaacccgga cctcactccc tgcttccaga actccctgct 21120 ggcctgggtg ccctgcatct acctgtgggt cgccctgccc tgctacttgc tctacctgcg 21180 gcaccattgt cgtggctaca tcatcctctc ccacctgtcc aagctcaaga tggtcagtgg 21240 ctcagggatc tcctaccgat ggggctgggc cctggggatt ctgcttttat tttttaattt 21300 aattaaatta attaattaat taatttagag acagagtctc actctgtcgc ccaggctgga 21360 gtgcagtggc atgatcttgg ctcactgcaa cctctgcctt ctgggttcaa gcgattctcc 21420 tgcctcagcc tcctgagtag ctgggattac aggcatgcgc caccacaccc agctaatttt 21480 tgtattttta gtagagatgg ggttttgcca ttttggcagg ctggtctcca actcctgacc 21540 tcaggtgatc agcctcccaa agtgctggga ttagaggcat gagccactgt gcccagccag 21600 cattctggtt ttaatgaggc cctctcccac ctcctcggct ggactgggtt ccccagtctc 21660 acctgacctg cttggggtca tgggaatctg acaactgaga atatatacag ccagctgaca 21720 tattccccac ttgggaaagt ttaagtaagt tcagcaacac tctccccacc tccagcaagc 21780 ttctggtcag ctccattccc agacctcagt gccagtccca ggcaggtcta gtggattctg 21840 gtggcttcag gtacaaagac cccttcccag tgaggactgt ccttgcctct ggggatgcgg 21900 attccaacct gtgctctctt cgcaggtcct gggtgtcctg ctgtggtgcg tctcctgggc 21960 ggaccttttt tactccttcc atggcctggt ccatggccgg gcccctgccc ctgttttctt 22020 tgtcaccccc ttggtggtgg gggtcaccat ggtcagtgtg gggccctggg aaagtggatg 22080 ggggaggtct ccattgggtt gtggactgtg atagggaaac tgtgggctct gaggagaggg 22140 ctggacatat tgggaatggg aagaagaagg gggtggcccc agaaacttct ggccatgtgg 22200 gatggggaga aatggaggca ggtccagatg tgtgtgttct gcccgggcct ccctgccctc 22260 cctgcacagc tgctggccac cctgctgata cagtatgagc ggctgcaggg cgtacagtct 22320 tcgggggtcc tcattatctt ctggttcctg tgtgtggtct gcgccatcgt cccattccgc 22380 tccaagatcc ttttagccaa ggcagaggta aggttggggg agaggggaac ctgccaggtt 22440 tagccctgat aggagggtga cctcagggtt caaagtcact gctgggtccc aggtccctcc 22500 ctcgaggctt caagtacaaa cacaattgtg ttgttctcca cttgctacat ttctacctgg 22560 aagcaggctg aggagggggc accagtgtaa cacaggaatg agccaagatg ccaccactgt 22620 tggaccatca tgtgagggta gggggctgtt ccacagcacc cacccaccaa gtgcaatatc 22680 tgacgtgggt gtcagtcagt gcctgtgtaa tgaacacatg tatgcagaca agtgtgaaga 22740 gttctggctt acctagaggt cccattagca tgttcccttc ctttcttccc acctccctca 22800 gttcctggcc ttcctcttga tcttcagtgg ctgtgatgtt gggctggtgg gatggaacac 22860 tgcaggccaa cctagtgcct cccatttctc catctcagcg ggaagcaggc aaggagagta 22920 gcaaagaaca taggctgtga acaacccact tactccccat gtgggctcgg gcgggtcgct 22980 gaaacctttg gagcctcatt tccttaattg cagaaagggc gtcatgagct gtcctgcctg 23040 taggctgatg tcccagttag acaaggtcat gtaggtaagg tgatggcacc acacctggca 23100 caggtgccac acctggtcct cgctgaacca gagctccctt gtgatccttc ctcatctctc 23160 agagtcctct gagtggggac ctggaggccc ccaggtgctg cctcctgccc cagaggagac 23220 tgatgcccca agggactccg cagggcaggg gctgcaggcc caggcttttc cagtgcttct 23280 gacgcccctc cactctccca cccagggtga gatctcagac cccttccgct tcaccacctt 23340 ctacatccac tttgccctgg tactctctgc cctcatcttg gcctgcttca gggagaaacc 23400 tccatttttc tccgcaaaga atgtcgaccc tgtgagtttc ccatggaggg tgcgggggct 23460 ccacagctga gtcctcagcc caactctgac cagcagcccc caacccctcc agttcctttc 23520 aaagtgggag agaggtcatc cccacaatct gtaaactggg gcttggagca ggaacaaggg 23580 tcccctccat ttccctactc tgctttgaga gggtggtggg cactcctgat tcccccgtcc 23640 tattctctcg ccttctagaa cccctaccct gagaccagcg ctggctttct ctcccgcctg 23700 tttttctggt ggttcacaaa gtgagttggc tcttccacca gccaggccag agggagggga 23760 gggatggaag gtgagatgga gaaaggggag cagggcagca gtttagggac cgggctggcc 23820 acctatccca ccccccaccg cagtgggcac agggcagatg agggtaggga agtggtctgg 23880 gagggggacc aaatgcagag gcctggcctg gcccagtgcc gcccccaggc tacaggccag 23940 ccctgcatct ggcaggctgt ggggacaggc ccaggaggct ggaagaagac tgtcattagt 24000 tctgagctcc tctgtttgtg ataaacttgc agcctgtcat ctccttggct gcgcctcaga 24060 gcggcttgag caggataact gtgtctgtga cctgggtgac agctcattaa ccccacagca 24120 ctgaggaagc acccgaggct ggggccaaat tgcccaggcc tcgtcctcac ccagggcccc 24180 aggcagcgtg gattccatca ccagggcctg gggtggggag gagatgggac acctggggag 24240 gaggaggaga agggggtagt ggtaggaact tcggagggag agccagtgac ctcaagccta 24300 ttcactgagg aaatgaagga gacacctttc atggtcacag tgcccgaggg agaccctcct 24360 ttctggagac cctggggccc tggagacact gacccttggc tccaggctgc taaaccctga 24420 ccctctgcgg ggctgcctgc cgggcttcac ctccccccag gatggccatc tatggctacc 24480 ggcatcccct ggaggagaag gacctctggt ccctaaagga agaggacaga tcccagatgg 24540 tggtgcagca gctgctggag gcatggagga agcaggaaaa gcagacggca cggtgaggcc 24600 ctccccttgc cccaacaccc agccccttcg cttaccccag atctcctgca gaggacgctg 24660 gtagaccttg gagggcggca ttgctggggt ggcaagcaga gcaggaccag gtgatttctt 24720 ggcagcctcg ggaccattct atgggaagct taggcctgga tggcgctagt tctcccagct 24780 ctggtggggg caggagaatg gctggcactt tggagcaact actccatccc aggtcccatc 24840 ctaaggatat aaataaactc acttaatttt tcaacagccc taaagggtag gttcaagtgt 24900 ccctgtgtta cagatgggga cactggggcc gggtgtggtg gctcacagct gtaatcctaa 24960 cactttgaga tgccaaggca ggaggattgc ttgagtccaa gagttcaaga ccagcctggg 25020 caatatagtg agaccttgtc tctacaaaaa ataaacaaga tgagccgggc atggtggtgt 25080 gcacctgtag tcccagctac ttgagaggct gaggtgggag gatcatttga gcccaagagg 25140 tcaaggctat agtgagctga gattgtgcca ctgtactcca gtctgggcaa tagagtgaga 25200 ccttttctca acaacaacaa aaacagatgg agacaccgaa gcacagaaat ttaacagagg 25260 gcctcccagg gtccccaagt tggtggtggc agagctggaa tccacatgga gccggctggc 25320 cccagaggtt ctcctcatat cactgcacca ccctgcctga ctgagagggc tgattccagg 25380 gccaggagcc agcacacccc tgccaattct gcctcctcct gtctggaggc ggcggctgaa 25440 tgagatgatc ttcccctgag gggtcttccc actgtcagcc tcttatcaag gaccacaaac 25500 ctgtctctgg ccaactgcct caccaagaga gctgacgctg agcatcatct ttctccaccc 25560 aattctgacc ccaggattga accctccctc ctcccatcca caatccaggc ctaggagttc 25620 aatgtttgct cagcccggag cttccggttg tcaccagctg ttggaggagc ctggggctgg 25680 gcatggttag cagtatcctg gctttcatgg cttggagcct ccacgaagac ctatgggccc 25740 ccagtctgcc tgctgcaccc cctctcagtc cctccatgcc actccacccc ctccctgttc 25800 agctgcccgg tggctgtacc aacagccatc cttgatctta tctaccttcc ctcttggcgt 25860 cctccctgga gccagcactg gggaggcggg gagagggcca gactgggggg atagctgggt 25920 tttagagtcc ttgtggtagc agtctggcca ccccttcaga tgccctctgg cagctgagga 25980 cagagtcgct tgtgcaattc ttatgctgtc tgttcccctc ccagctctga gagccaagaa 26040 aacagctcct tcctcctcct cactcctagc cagcccagcc tagcccttgg cttcctggag 26100 cccctgtccc cattcctaac ccactgctcc ttcctccctg gaccagacac aaggcttcag 26160 cagcacctgg gaaaaatgcc tccggcgagg acgaggtgct gctgggtgcc cggcccaggc 26220 cccggaagcc ctccttcctg aaggccctgc tggccacctt cggctccagc ttcctcatca 26280 gtgcctgctt caagcttatc caggacctgc tctccttcat caatccacag ctgctcaggt 26340 ctctccacac tccggctcac tatagccctg ccctgggcag cagggctggc tggctagccc 26400 agaggaagga acaacgtaca gtgaaaagaa ccccagacca ggaaccaggg aggctagctc 26460 cactttctgt gtgacctttg gcaagtggca ttgcctgact tgtttcctca ctcacattca 26520 acttagaatt gctgtgcata tactatgtgc cgggcaccgt ggtgtgtacg ttaacaagca 26580 ttgggtcttt aaatcttccc aacaatccta tgcggaattg ccccattccc atgtcacaga 26640 tgagaaagca ggaactcaga gaggtgaagt gacttggcca agggcacaca gcaaagaagg 26700 aatcaggtct gagtccagga ctctgagctc cgactgaggt gctctgtccc caccatcagg 26760 ctctaacatc tgtctcagga atggcttgga ctagaacgag ctctcaaatg agagggtggg 26820 aaggagagct gcctagtagc taagtcccca cctccttgcc cctccgtgca tgcattaatt 26880 tgttcagcaa acatttattg aacctccagg gtaccagaat ggtgctcgat actagggata 26940 cagagttcaa taagacaggg tcttgatgtc ttatgggaga aaccagcgtg taaatcaatt 27000 agaattcagt gggggcagaa gtgttctcgg gtgtctggaa aaccccggga ggggcaaaga 27060 agccagcctg ggatgcagca ggaagcaccc actggcttgg gaggtcaacg aatttggaga 27120 gacaagtagg tgaagaaaca ggggaaagtt cagcctcagc ttagtcacaa agccctgaaa 27180 cagcatgact caggtgtttc tgagtggcag aggaaatggc aacgagaggg aggggcagga 27240 aaacagagag agggagagct aaggatatcc ttgaaagatc tgagccaggg aggggcatct 27300 ggcttcaagg atctcctgcc aggagtgtgg gggatgtagg gcagggtggc tggatggaag 27360 tgggccaacc cggtcagatg gagtccaggc caggaatgag acaagtattc aggagcaatt 27420 tgggagatgg gcgtgtgcgc cagagagaca gaggagtgcc aggcaacctg ggtgctggcc 27480 tgggtaactg gaggacgatg gatcttttgc tgagctgatg ggctcggtgg gaggaggagg 27540 ctgggtgggg ggcaaggtgg tggatggagt ctggtcatgt ggggccagtg gtgctggtgg 27600 gtcctccaag gggagattcc cagctagctg gaagtcaaac tctcgagccc aagagtttga 27660 gaccagcctg agcaacatag caagaccctg tctctacaaa aaagttaaga tattagccag 27720 gcctggtggc atacgcctag agtcctagct actcaagagg ctgaggtggg aagactgcct 27780 gagcctgaga ggttgaggct gccgtgagct gtgatggcac caccgcactc cagtctaggt 27840 gacagagaga gaccctgtct caaaaaaaaa aaaaaaaaaa aagagagaga gagacaccag 27900 tcactgggct ggggccactg gggcccaccc tactccaata tgacctcacc aaatgaggcc 27960 acgttcacag gtaccaggtg ttgggagctg aacatatctt tctgggagac acaacttaag 28020 ctatcacaga aggggaggcc tggctatgat tatggctgga gggctccatg tagtcgagag 28080 gagagtgtcc caacaatgaa gagactcggt catgtcaata ggtgaaggtg tagagcttcc 28140 agcagaggtg gccagggtga agctcagcgg caaagggggc aacagcgcag caagttcctg 28200 aggaggcaga ggaaggccag ggctcggggg caggggcagc ctccgacagc ctgagcacca 28260 gaaaaaggag gacaagccac tggagggcag tttgtgagtg gcaaggagtt tgtgggtggc 28320 agggagttct caatgggtgg ctaagcaaga aggcaggtag ctgctgagag gggtgggggg 28380 ctgggatggg cctgaaggga agagaagaga ggtgaagaag gccccaagag cgggggcgga 28440 ttagggacct agagaaggtt gctaggcagt gctgggggcc actgagtttg gaaaggtgga 28500 tttgagcggc aagagtcttt gtggtcatgt ggcggaatct agagccccca gcagcctagg 28560 agaaggagca gggaagtcca gtcaatggaa acgtggcatt tcttcccgcc atatgtcagg 28620 aggtaagaag gcaggcaggt gaggctggtg gtgagagcgt catcgatagg gcgtgcagca 28680 gggtccatgg tggatagaga acgaggtgaa ggcagagtgg agccaggagg tcgtggtctt 28740 gaggcagtac tgggttgacc ctccctggcc caagaggttg gagggggtgg aggtttcaga 28800 ggccaggggt gcagtggaga ctgcgggtaa aagcaaaggg cagcagagga gggagcagcc 28860 atgggggcag cactgcccac ctcactcctc tctcctcccc acagcatcct gatcaggttt 28920 atctccaacc ccatggcccc ctcctggtgg ggcttcctgg tggctgggct gatgttcctg 28980 tgctccatga tgcagtcgct gatcttacaa cactattacc actacatctt tgtgactggg 29040 gtgaagtttc gtactgggat catgggtgtc atctacagga aggtcagctg gagcagggcc 29100 caggggaaag gctggccctg ggcagcttgc aagaggctcg cagccaagtc cacccactac 29160 tgtctacctg caggctctgg ttatcaccaa ctcagtcaaa cgtgcgtcca ctgtggggga 29220 aattgtcaac ctcatgtcag tggatgccca gcgcttcatg gaccttgccc ccttcctcaa 29280 tctgctgtgg tcagcacccc tgcagatcat cctggcgatc tacttcctct ggcaggtgac 29340 tctccaaccc tgacctctgc ctccttcctc tgacatgctg cagaagtggc aagagaggat 29400 tattctggaa ctgggagcat ggcacatgct tgtagtccca gctgctcagg cggctgaggc 29460 aagaggatca cttgagccca agagttctgg ctgcagtgcg ccacgattgt gcctgcgaat 29520 agccaccaca ctccagcctg ggcaacatag caagaccttg tctctaaaaa gaaacaaaga 29580 aaacagaaaa aaagaaggag ggttattctg ggttagcaga ggggatatag aattgacaca 29640 agagctggct gggcacggtg gctcacgcct gtaatcccag cattttggga gaccaaggcg 29700 ggtggatcac gaggtcagga gttcgagacc agcccggcca ggatggtgaa accccatctc 29760 tactaaaaat acaaaaatta gccagacgtg gtggcgggtg cctgtagtca cagctactca 29820 ggaggctgag gcaggagaat cgcttgaacc caggaggcag aggttgcagt gagccgagat 29880 cataccactg cactctagcc tgggtgacag agcaagactc tgtctcaaaa aaaaaaaaaa 29940 aaaaaaaaaa agaattgaca caagagcttc cctaggcatt ggtggggatg gagggatagg 30000 acttcgagga tgctgatgtc tgcaaaggaa tcttcccaac atctgttgct atccttcctg 30060 cagaagccag ggaggaaaga aagtcttgga gggaggtggg tgtgactctg gctgtcatcg 30120 tctatatttg ccttcctgtg tgtctggaca cccttctata tctgctgtct gtccctgtcg 30180 tcgttatcta atggctggct gcttctacaa atgttgtggt cattctgact ttctatctgt 30240 ttggccaacc accatctttt gcttcctgcc catctacaca tttcaagtta acaggcctct 30300 gtttgcctgt tgggttctct ctgtagactt tggtaatctg tccctatgtg tcatctatcc 30360 accggtgcct cctcagaacc taggtccctc tgtcctggct ggagtcgctt tcatggtctt 30420 gctgattcca ctcaacggag ctgtggccgt gaagatgcgc gccttccagg taggtgctgt 30480 cagaggtgca tcctcctgcc tgcagcaccc ggccggctgc ctgggggaag gtgtccacta 30540 accttggggc ctcccaacta ccttgcttcc tgagtatgga tggctactag ccatttgcag 30600 aaaccatagc tcactcttcc ctcacagctc tcagagggtt ttactgacat tctcattttg 30660 tagcagaaga ccaacgctta gagaaataat ggcagtccag aatcaggcag ggctgggact 30720 caaacctgac tatcctggtc taacaaggag ttttcccgct gcactgtgct aagcatgaat 30780 agccagtcac tcagtctact atttgcaaac atttcttgaa gtgttttttt tctttttttt 30840 tttttttgag acagggtctc gttctgtcac ccatgctgga atgcagtggc atgatctcgg 30900 ctcactgcaa cctctgcctc ccgggttcaa gcgatcttcc tgcctcagcc tccctagtag 30960 ctgggactac aggcacatgc caccacaccc ggcttatttt tgtatttttt tttttagtag 31020 agatggggtt tcaccatgtt ggccaggctg gtctcaaact cctgacctca ggtgatccgt 31080 tcatcttagc ctcccaaagt gctgggatta caggtgtgag ccatcacacc tggcctattg 31140 aagtctacta gcttcccact gcccatagga aaaatgacaa accccctaag aagactcagc 31200 aggcttctgc ttaccttgca agtcctcacc ccctgcggac tggccaagtt tcagccagtc 31260 tggtcttctt tcttttctcc acagcaccaa gctcagggta cctctagggg ccaccacata 31320 tactattccc tctgcctgga atgcttgtca tccccctctt gcctgcctaa ctcctttcct 31380 tcccttacct ctcggcattg aagtcacttc ctcggctggg cacggtggct catgcctgta 31440 atcccagagc tttgggaggc cgaggcaggt ggatcacctg aggttgggag atcgagacca 31500 gccagaccaa catggagaaa ccccgtctct actaaaaata caaaattagc cgggcatggt 31560 ggcacatgcc tgtaatccca gctactctgg agtctgaggc aggagaatcc cttgaatcca 31620 ggaggcagag gttgcggtga gccaagatcg cgccattgca ctcccacctg ggcaacaaga 31680 gcgaaactcc gtctcaaaaa aaaaagtcac ttcctccaga agtccaccct gactgcccag 31740 tctcagtcta agttagtttc cctgccatca cctcattact ttcttacagg atcctgtgat 31800 ttcccatcag aacacacata atgattaata attaagcatt tattcagatc attgtttgct 31860 tattgtatgc ctcccccatc agatcgtcag ctgtatcatg gcaggggcct tgtctgaatt 31920 catcgtgaca aattctacac gtagcccatg gcctggcaca tagtaggcac tccataaata 31980 ggggttgaat gaatacatta atctggtgtg ccacaccttg ggctaaggtc ttggagaaca 32040 aagagaaata aatagtccat cccctcagga agctcacagt ctgattagag aaacatatat 32100 gtaaaggaat ggttatggaa caaaaggaaa gtgcaatgtg ctttagaaac ccagggaagg 32160 ggaccaggtg tggtggctca cacctgtaat cccagcactt ggggaggcca aggtgggagg 32220 atcacatgag gccaggagtt tgaaatcagc ctgggcaaca gagtgagacc tcgtccctac 32280 aaaaaaattt aaaaattagc tgggcatggt tgttcatgcc tgtagttcca gctagtcagg 32340 aggctgagac aggaggatca aaggagccca ggagtttgag gctgcagtga gctatgattg 32400 taccactgca gtccagcctg ggcaacacag tgaggcacca tctctaaaat aaataatact 32460 agcaataata ataagaagaa gaaaaagaag tagtaggaga agaaacccag ggcaggggac 32520 agaggatgct gcctggggag gccggtgcag tggcactgag ggtggagatg gatcttgtca 32580 ggcagaggac acagggaggc aggggctgtg cattccaggc caaggcacag cacaggccca 32640 gcaaggagtt gtgagaagga atggtgggca gcgtggaatg gctgcaatgg atgagaatgg 32700 atggaaggta ggaccctgtg agcaggaggt caggggaggg agcaggtgtg ccactgacac 32760 tctttctgcc tgcacaggta aagcaaatga aattgaagga ctcgcgcatc aagctgatga 32820 gtgagatcct gaacggcatc aaggtgctga agctgtacgc ctgggagccc agcttcctga 32880 agcaggtgga gggcatcagg cagggtgagc tccagctgct gcgcacggcg gcctacctcc 32940 acaccacaac caccttcacc tggatgtgca gccccttcct ggtgaggctt ggcacagggc 33000 tgggtccctg cctccagggc tctgggtgcc caggcatggc cagggctcat tggactctac 33060 cctgacacca cctccacgct gctcaggtga ccctgatcac cctctgggtg tacgtgtacg 33120 tggacccaaa caatgtgctg gacgccgaga aggcctttgt gtctgtgtcc ttgtttaata 33180 tcttaagact tcccctcaac atgctgcccc agttaatcag caacctgact caggtaaccc 33240 tgggtagggc tgggggctct actggagttg gaacaggttg ttggggtcag ggaagggtca 33300 cttagggcaa gggataatca gggggagtta ttggattcag ggaaggttgc tagcattatg 33360 aagagctatt caaggttgaa tgaggtcatt aaggtcaggg gtcatttgga gtcacaggtg 33420 gtcaggtcgg gtgtctggaa acctgagttc tgtagatagc ctcctcttac caacctggac 33480 tttctctttg ggcagtggga gccatggaag actcagtcgt gggagggacc ccagtgctag 33540 tgtctgggcc ctcagggggt cctgcctagc ccaggatgct ggggatgggg cgagggtagg 33600 ggttgggggt tgggaaagta cagtctctag ggctgactca catcctcccg taggccagtg 33660 tgtctctgaa acggatccag caattcctga gccaagagga acttgacccc cagagtgtgg 33720 aaagaaagac catctcccca ggtctagaga gcccctacct gggctgcctg ccccagtcct 33780 tgctccagaa aaacctctgt ttcaagcttt tcctttgttc tctcctgacc ccttttcttc 33840 ttcctctgtt cacatctgct tcgactctga cctcctccct cttccgggtt ctctgctctc 33900 ctccgccctc ctccacaggg ctccccacat ccctttcttc ctcccttttc ccaaggatcc 33960 cctccccatg gcccaggctc ctcccctgtc ctcctttccc ctgcccccca gcctccctgc 34020 aggctacccc atcccttgag ctccctccct gaccctgccc accttggtcc tctcaggcta 34080 tgccatcacc atacacagtg gcaccttcac ctgggcccag gacctgcccc ccactctgca 34140 caggtaccag cttctcccac tcccttccca gctgcccacg gtgggctgga agttcagatc 34200 aatagcagca ccctgcaaag cctttgacca agaatgcagg aagagcttca gcctgccagg 34260 ggggtgtctg gaagggcgga gggcttggtt ctgcaggtgg agggttggag accaaaaccc 34320 tgatccctgc ctctaactgg actcctgggg tccttgcccc cagcctagac atccaggtcc 34380 cgaaaggggc actggtggcc gtggtggggc ctgtgggctg tgggaagtcc tccctggtgt 34440 ctgccctgct gggagagatg gagaagctag aaggcaaagt gcacatgaag gtgagagagg 34500 caggggctcc tgggcagggt gtggggctca gccaggcctt gggcaagccc cgaggtaaat 34560 ttctcctgtg gccagggctc cgtggcctat gtgccccagc aggcatggat ccagaactgc 34620 actcttcagg aaaacgtgct tttcggcaaa gccctgaacc ccaagcgcta ccagcagact 34680 ctggaggcct gtgccttgct agctgacctg gagatgctgc ctggtgggga tcagacagag 34740 attggagaga aggtacagag tcctcttcca tccctaagag gctagggcat agagctgccc 34800 acctcaaccc agcccaggtc catatattca tcccttcatt cacacattgg tgtaacgtta 34860 tgcccaactc tgtgccaggc actggggaaa cagatctatt agcagatctg tttagtgaac 34920 aagtaggaac tattgaatat tctaggagcc aggctgaagg cctgtgcagg gtacagggag 34980 ggcacagcag ggagcctaca taaggaagag catcactttt tttttttctt tctttctgag 35040 ataaggcctc actctgttgc ccaggatgga gtgccatggt gacatcatgg gacgctgcag 35100 cttggaactc ctgggctcaa gtgatcctct cgcctcagcc tcctgagtat ctgggaccac 35160 aggcacatgc caccataccc agctaaattt ttaatttttt ttagagacag cgtcttgcca 35220 tgtcgcccag gctggctcag gagatcctcc caccctggcc tcccagagta ctgggattac 35280 aggcatgagc tgctgcacct ggctgagcat cacttttttt ttttagacag agccttgctc 35340 tgtcacccag gctggagtgc agtggcgcag atcatggctc actgcaacct ccacctcccg 35400 ggttcaagca attctcgtgt ctcagccacc cgagtagctg ggattacggg tgcgcaccac 35460 cacacttggc taatttttgt gtttttagta cagacggggt tttgccatgt tggcccatct 35520 ggtcttgaac tcctggcttc aagtgatccc cccgcctcag cctctcaaag tgctgggatt 35580 acaggcatga gcaccgtgcc tagccttaag catcactttt gacctcagtt ttaacaactg 35640 aggaggagga gctcatcatg tatctgttca ttcatttacc atatatttat taagcaccca 35700 ctctattctg ggaaatagta tacagtagtg aatactaaaa tgccgggcta atatctctac 35760 cttcatatag ctcacattct agtggcagga agagataata agtaagataa ataagtacaa 35820 tatataatat gttagataaa tgctcagtgg aaaaaataaa gcggggaagg aatacaggaa 35880 tgcctgcaga gttgaatggt taaggtagct tgggaaatcc tcactgagaa tcagagaact 35940 caacaaagag accgagtgag ccttgtctgg agccagaaag ctctgtctgg ggccatggaa 36000 ccctgtatgg ggtcttggag ttctctggca tgactaggag ttgggaaatg gagggaaaag 36060 atagagagag gcagaaccct gattaccttg gttaagattt tggcctttac tctaaaaaac 36120 atggaacact ggggaaaatt tggggctttg ctttttaaca atttttaact gtggtaaaaa 36180 ccacacataa cataaaatat atcatcttgc ccggcatggt ggctcccagc actctgggag 36240 gctgaggcag gtgtatcatt tgaggtaagg agttcaaggc cagccttgct aacatgataa 36300 aaccccatct ctactagaaa tacaaacaaa ttagccgagt gtgatggcgt gtgcctgtag 36360 tcccagctac tcaggaggct gaggcaggag cattgcgtaa gcccaggagg cggaggttgc 36420 aatgaactga gattgattgt atcactgcat tccagcctgg gcgacagagc aagactctgt 36480 cttaaaaaaa aaaaaaagaa aaaaaaactt aatcatttct tagtgtacag ttcagcaatg 36540 ttaagtacat ttacattgct gtgcaaccga tctccagaac cttttcatct tgcaaaacta 36600 aaattgtgcc tattaagcaa ctcctcattc cccactgccc ctaggcccca gtaaccacca 36660 ttctattttc tgttcctagg aatttgacta cttagtatct tagtccattt tctattgctt 36720 ataagagaat gcctgaaact aggtaattta taaagaaaag aaatgtattt tgtacagtta 36780 cggaggctga agagtccacg gtccaggggc tgcatctgga gagggcctcc ttgttggcgg 36840 ggagtctgca gagtcccaag gccatacagg gcatcccatg gcaaggggac cgagcatgct 36900 agctcaggtc tctcttcctt ccttcctttt tttttttttt tttttttttt ttttttgaga 36960 caaggcttca ctctgttgcc cagactgtag attggagtac agcggcgtga tcttggctca 37020 ctgcaacctc cgcctcccag gttcaaacga ttctccttcc tcagcctccc gaatagctgg 37080 gattacaggc gcacgcaact acagcccgac taatttttgt atttttagta gagatgggtt 37140 tcaccatatt ggccatgctg gtcttgaact cctgacttca aatgatccac ccacctcgac 37200 ctcccaaatt gctgggatta caggcatgag ccaccacgcg cgacctcagg tttctctttc 37260 tttcttataa agccaccggt cccactcccc cagtaaccca ttcacgcatc aacctattaa 37320 tccataaatg gatcaaccat tcatgagggc tctgttttca tgacctaatc acctggtaaa 37380 tgccacccct caatcctgcc acactggggg gtaagtttca acatgcactt tggaaggaac 37440 aaatatttca accatatcac ctaggtacct cacgtaagtg gaatcatcca gcatttgtct 37500 tttcgtgacg ggcttatttc acttagcata atgtcctcaa ggcatatcca tgttgtagca 37560 tgtgtcagaa tttccctcct tgtaaggctg aatgatattt cattataggt atatacacat 37620 ttgtgtgccc atttatccgt agatgggttg ggcaggacac caagctgggc agggtggtga 37680 ccaatggagc agaatggcct cacctgcccc aggaggactt accctttacc tctgtccctc 37740 acagcattgc agggacagac taggccccat gtgaaatata gattcagaag actgctgttc 37800 tggtcaggca cagtggctca cacctgtaat cccagcactt tactttggga ggctgacgtg 37860 ggccaattgc ttgagctcag gagttggaga ccaggctggg caacatatgg agattctgtc 37920 tctataaaaa ataaaacatt ttagtcagta gccaggcatg gtggtcctgc aatcaatcct 37980 agctactcgg gaggctgagg catgagaatt gctcaaacgc gagaggcaga ggttgcagtg 38040 agccaagatc gcaccactgc actccagcct gggtgagtga gaccccatct caggaaaaaa 38100 aaaaaaaaat ctgccatccc aaataacagt ggacaggccg ttgtctccct gtgcctgtct 38160 gaccccattt ttcccacccc ccgcctccct ccagggcatt aacctgtctg ggggccagcg 38220 gcagcgggtc agtctggctc gagctgttta cagtgatgcc gatattttct tgctggatga 38280 cccactgtcc gcggtggact ctcatgtggc caagcacatc tttgaccacg tcatcgggcc 38340 agaaggcgtg ctggcaggca aggtgaggcc tgccagaggc taagggggct aaggtgagat 38400 ctgaggcccg aagagagagc tggtgagagg ctgaggggtt tggatgagac ttggaggtgt 38460 ggggggcgca agaagtgggc atgtgggttg ggcatcagga gaaacctgtg gggacaactc 38520 ccccacctgc gaggttctga gcaggctgtg gcgagcacag ggtgagtcac ccatgtgcct 38580 gtccaagctc cctggcacat gggcacactt cacactcact ctgtggctcc gtgcctgtgc 38640 caggggtgtg ctggagggtg gtaggggtga gagcctgctg ccttctcccc agacgcgagt 38700 gctggtgacg cacggcatta gcttcctgcc ccagacagac ttcatcattg tgctagctga 38760 tggacaggtg tctgagatgg gcccgtaccc agccctgctg cagcgcaacg gctcctttgc 38820 caactttctc tgcaactatg cccccgatga ggaccaaggg cacctggagg acagctggac 38880 cggtatctgc catcctgggc cctctgattc ccatgccttc ccagcattcc ccctgtctgg 38940 ggtctctgag tgtgtctaga ctggcctagt gttgtgccag gcaggttctg ggaaacttgg 39000 gccatctgtg tgacagtcac cagaggtaaa gtaaactgga catagtcggg tcccactgcc 39060 tcctccatcc tactctaccc taactgtggg aactcagatc ctccgccccg gtctcagagc 39120 ctgttttctt tctttctttc tttctttctt tctttctttc tttctttctt tctttctttc 39180 tttctttctt tctttctttc tttctctctc tctctctctc tctctctctc tctctctctc 39240 tctctctctc tctctctctc tttctttctt tctttctttc tttctttctt tctttctttt 39300 ttttcttttg aggcagagtc tggctctgtc gccgggctgg agtgcagtgg tacaatctca 39360 gctcactgca acctctgcct cccaggttca agtgattctc ctgcctcagg ctcccgagta 39420 gctgggacta caggcatgcg ccaccacgcc tggctaattt ttgtattttt agtacagaca 39480 tggtttcacc atgttggcca ggatggtctc gatctcttga cctcgtgatc tgcctgcctc 39540 ggcctcccaa agtgctggga ttacaggtgt gagccacctt gcccgatctc agagcctgtt 39600 ttccatctgt tgaaagcata ggagggccca ggcccagctt gtgtggcaag gctgcttcat 39660 ggataaatag tttggcaagt atgcaagtgc ttagcaaagc cgcttattta tcaaccaaaa 39720 tttattggac aatcactata tacaggcact gttccagaca ctaagctata gcagtgagca 39780 aacaaaaaaa ttatagtcct catggagctt gttgacgtct ctgggctcac aacatgcccc 39840 tggctccttg ttgcccagac ccagctcccc agcccccaat tctggattgg ctcacagacc 39900 ttttcctggg ctttcttgcc tatggctata catacagcca acgtgccttg agcatttacc 39960 aagtgctgtg cccctcgctc acacactgga cacattttct tttaagccta cagtcatgca 40020 gatttttttt tttttttttt ggggacagtt tctcactctg ttgcccaggc tggagtgcaa 40080 cggtgcgatc ttggctcact gcaacctttg cctcctgggt tcaagcgatt ctcctgcctc 40140 agcctcccga gtagccagga ttataggtgc ccgccaccac gcccggctaa tttttgtatt 40200 tttagtagag acggggtttc accatgttgg ccaggctggt ctcgatctcc tgacctcgtg 40260 agctgcctgc ctcagcctcc caaagtgctg ggattacagg cgtgagccac catgcccgac 40320 caaggacgtg agttttaagc tcagccagtc taactccaga gcccaagttc ctaacccttg 40380 tatttgagtc cgtttctcca taatttgtga agagagtttt tcttgttgct taacccaagt 40440 ctttcttgtt gccctttcaa tccccctcat tttattttca tgcttgtcca ttgaacccct 40500 ttcattagag tggggaatgg gagataccag gggcttgcag ggagaactag ctgaacccta 40560 tctccttcct cccaccctac tgcagcgttg gaaggtgcag aggataagga ggcactgctg 40620 attgaagaca cactcagcaa ccacacggat ctgacagaca atgatccagt cacctatgtg 40680 gtccagaagc agtttatgag gtgagttcct gagagctccc agccctcccg gaggctgtat 40740 caggcctccc caggccctgc cagatggggt gcaggtttct ccctgacact cccagcctct 40800 gtcctggggg gtgcttgagg ccccctccct gggcctgacc agctgcctcc acagacagct 40860 gagtgccctg tcctcagatg gggagggaca gggtcggcct gtaccccgga ggcacctggg 40920 tccatcagag aaggtgcagg tgacagaggc gaaggcagat ggggcactga cccaggagga 40980 gaaagcagcc attggcactg tgagtcggtg gggcaagagg ggctggaggg gatggacagg 41040 caggccccag cagccccagg gtttatggag tcccctgtcc ctgactgcca tggctgctcc 41100 ctacaggtgg agctcagtgt gttctgggat tatgccaagg ccgtggggct ctgtaccacg 41160 ctggccatct gtctcctgta tgtgggtcaa agtgcggctg ccattggagc caatgtgtgg 41220 ctcagtgcct ggacaaatga tgccatggca gacagtagac agaacaacac ttccctgagg 41280 ctgggcgtct atgctgcttt aggaattctg caaggtgagc ttgtgggggt gtccagaagg 41340 ggctccaata tcccttcttc tctgggctgc caggcccccc aaaccgtgcc cttgcatcca 41400 agcctcccta acccactctg gtcaacccgt gtctctgatt ctgccccttt gtgcccgctc 41460 actagtccag gtgagccagc gccctctgcc ttctccaaca gggttcttgg tgatgctggc 41520 agccatggcc atggcagcgg gtggcatcca ggctgcccgt gtgttgcacc aggcactgct 41580 gcacaacaag atacgctcgc cacagtcctt ctttgacacc acaccatcag gccgcatcct 41640 gaactgcttc tccaaggaca tctatgtcgt tgatgaggtt ctggcccctg tcatcctcat 41700 gctgctcaat tccttcttca acgccatctc cactcttgtg gtcatcatgg ccagcacgcc 41760 gctcttcact gtggtcatcc tgcccctggc tgtgctctac accttagtgc aggtgtgggg 41820 tgggcgtgat tccagtgtgg gcgtggtgtt attggggcgg ggcaacacat gggcgggggc 41880 agcaggggtg ggacacttca ggccaccaac attacagagt tttgttaggg gcagtcgttg 41940 cttaacattt atgttagggg agccattact taacctcttt gaaactcatt tgcctcacct 42000 gtaaaataga atgactcata gaccttcctc atggagttgg tgagagaata aaatgaaata 42060 gttatacatt gtagctggca ctgggacttt cctgttggct tttttttttt gggggggggg 42120 ggacggaatc tcgagtctcg ctctgtcgct caggctggag tgcagctgca cgatctcagc 42180 tcactgtaac ctccgcctcc caggttcaag caattctgtt tcagcctccc aggtagctgg 42240 gattacaggc atgcgccacc acgcccagct aatttttgta gttttagtag agatggggtt 42300 tcactatgtt ggccaggctg ctcttgaact cctgacctca agtgatccgc ccacctcggc 42360 ctcccaaagt gctgggatta caggtgggaa ccaccatacc cggccttcct gttggctgtt 42420 ttttgataaa acattgtcaa cagtttggga cacattatcc tttccttcct tttatacata 42480 tctaaacata cgtgtatgca tgcgtttaac atagatgagt tgataacctt cagatacagc 42540 taactgtaaa aggcctttgc agacactgaa ctcctgttct gtaatgaatt agtcagttcc 42600 cggggataga tgctcaacac ctgggtatag cgaccatgat ctaggctgtg ctctgtgctg 42660 ggctagggga gaatcagata gacatcctgt atagcctgga tatctgaggc cacagaggag 42720 aggatggaaa ctggaggcag agccgtgttg ttgtggggtt gaagcagaga tgatcagagg 42780 gagggagtga atgacacatc aaggccccaa gtcttgggtc cttggaggtg ggggaaggca 42840 gcgatgtctc gtggtgggag tgaggctggc tgggaggact catctgaaaa tggatgagtt 42900 cagagacagg caggactgag ttgggggttc catggccctg accccaaact ccttctccct 42960 ccatcagcgc ttctatgcag ccacatcacg gcaactgaag cggctggaat cagtcagccg 43020 ctcacctatc tactcccact tttcggagac agtgactggt gccagtgtca tccgggccta 43080 caaccgcagc cgggattttg agatcatcag tgatactaag gtggatgcca accagagaag 43140 ctgctacccc tacatcatct ccaaccggtc agaagccgcc tccctcgctc cctgctcctc 43200 caggaattcc cagcaggctc tctggtgttc agggtccttg tccctccttt cccctaagca 43260 gaaaactggc cctgccctgc ccctgcccca tttcctcctc atctgatccc ccataggtgg 43320 ctgagcatcg gagtggagtt cgtggggaac tgcgtggtgc tctttgctgc actatttgcc 43380 gtcatcggga ggagcagcct gaacccgggg ctggtgggcc tttctgtgtc ctactccttg 43440 caggtatgaa gggcctggac cccagggcag ggccaccact gggacagaaa ccacacaggt 43500 gttccaggca tctcccgagt gcccctccct gctcagtatg ggcaccagcc acagggtctg 43560 ttctcaagga ctgtgagaaa aaaaaaaaaa gaaaaaaatc attgagttga caagtttata 43620 accacacacc atggctggat gttcctactt tccttcccca agaagcccat gttctcacat 43680 tcagaaagaa ttctgttgaa taatctctgt cctcaaaccc cacatctctc tcctgctcag 43740 ccgtcgacct tgcctgacac ctcacagttc aactggagag acccccatca gcaggagatt 43800 gtgctgcagg ctgagcaggt ctttgtggct ggagaaacaa aatgttttaa aagcccagaa 43860 gagggactgg gtgcagtggc tcacacctaa tcccagcact ttgggaggcg gaggtgggcg 43920 gatcacctga ggccaggagc tccagaacag cctggccaac atggtgaaac cctatctcta 43980 cttaaataca aaaattagcc agccgtggtg gcgggcatct gtaatcccag ctactcagga 44040 ggctgaggca ggagaatagc ttgaacctgg gaggcagagg ttgcagtgag ccaagatcac 44100 gccactgcac tccagcctgg gtgacagagc gagactccat ctcaagagag aaaaaaaaaa 44160 agtccagagg agttttcttg ctttggggtg ttgtagaaat gatcttggag cttagcccca 44220 aaggacaaac agaatttctc ttgtctctgg gcaagttgta ggctcatgtg acaggtcagg 44280 acagtgtagg gctggcatac cgctcgctca cgttcacatg cttgcagaga acgtacacag 44340 acgaggtgac tgaagcctgg tctgcaggtc aggcaggtca tcctgatgcc agcttgtact 44400 gtcaaagagt cacctaactg caaacggaat ttttgtaaag cagatcacat tgttaatacc 44460 tcaggtggct caaaccttga acgcgttggc aaacaaaaaa caatccagaa aggtcaattt 44520 tcacaaaggt cagtgtgcac atgaatctac ttgttaaaat gtacattttg attcagtaga 44580 cctaggatgg ggctcaggac tctgcacttt gatcaagact ccttggtacg caaagtgtgg 44640 cccatgggcc agttgcatca ccatcctctg ggagcttgtt agaaatgaag aatctcaggt 44700 tccaagtccc acctcagact acagaatccg gcgttgcatt ttaacaagat tctctgggaa 44760 gtcttataca tattaaagtt ggagaaacag aaaccaaggc gaggtggtcc ttggttaagt 44820 ctgcactgtc actgcccaag ggagtcattc gtgattacag ccccagctgg catgcctgtg 44880 ggcttgatcc aggcccacct gggtcatcca tgggctagga tcccatggat gggcacatga 44940 tccaggagtc tgaactcctc ccaaagccat tacggtgggg aggggagatc gccatacgta 45000 taacccagtc cctttggcca ggtgacattt gctctgaact ggatgatacg aatgatgtca 45060 gatttggaat ctaacatcgt ggctgtggag agggtcaagg agtactccaa gacagagaca 45120 gaggtgggta ctggcatgag cccgggacag ggggaatctg aagtagctgg ggaagaaagc 45180 ttggtggctc tctctccctc aacatcaggg cctgccacgt atggggctct tcattcattt 45240 acccattcac tccttactga gcatcaacca atgctctatg ctaggaggtg tagagagatc 45300 agagttgagc aagacggtgt ttgcccttag gtgattctga tttggtggga ggggtaagac 45360 ctattgcagg gctttgcagt ggatgaccag atctctggcg tggtgcacct ggagagggca 45420 gatgagggag atccttcagc tggggtgacc aggggagacg agcttagatg agaaggatgg 45480 acaggctttg atagactaag taagatggtg gggtgggcag tgggaaggtg agcattccag 45540 ccaaagagac cagcctgggc aaaggagtgg aggtggggca gcatgccctt tgttggggaa 45600 aaggagttgt tccctactgg gggttccaga cttttctcca ccgccccctc tcatggtcac 45660 accttagccc tcttcatgcc cagaagctgc agcatcagtg tcaagcatcc catctttggc 45720 ccacgctcct atcctgctcg ctctcatgct ccaagtcccc cactgtcaca gcagtctgcc 45780 ttcactggga ctcccaatcc catgaccccc ctttgtgtct ctgtccatca gcttctctgc 45840 cttcacctcc ctccccggcc agcctagagt ctatgctcca ccaacacaaa cgctctcacc 45900 tgccttgccc ttctctttct tctctctcag ttgtactcac ctccaaaacc caccccagct 45960 gagcccacca atctgccttc ttcatgcctg cactgagcac ttaaaacctt gcaggaggcg 46020 gggcacagtg actcatgcct gtaatcccag cactttggga ggccaaggtg ggtggatctc 46080 ttgaggtcgg gagttcaaaa ccagcctggc caacatggtg aaaccccatc tctactaaaa 46140 atacaaaaaa atagctgggc gtggtggtgc acacctgtat tcccagctac ttgggagtcc 46200 aaggcaggag aatcgcttga acccaggcgg tggaggttgc agtgagccga gattgcgcca 46260 ctgcacccca gcctggataa cagagtgaga ctctgtctaa aaaaaaaaaa agcttgcagg 46320 agaaaaatca ctgagttgac aagtttataa ccacacacca cggctgcatg ttcctgcttt 46380 gcttccccaa gaagcccatg ttctcacgtt cagaaagaat tctgttgaat aatctctgtc 46440 ctcaaacccc acatctccct cctgctcagc catcgacctt gcctgacacc tccataaaaa 46500 gtaggttcta agacgtgaac tccctcaacc ttcctgcctc tcagtcttta aacccgcctg 46560 tgtctccttc accgttgtct ccttttcact tttagcagga atcatccctt tctgtttcaa 46620 agcccagccc ctccatttct tctcatggcc gcttgaggac ctggcttcct cagtcccgcc 46680 ctccatctcc tgtcattctt gctccctctg ttggacgctt cccatccaca tgcaaaaata 46740 ttccatcaca tcttccattc cagacacaca cgcaaaccct cccccctgca ctccactgcc 46800 ccatttctct gctctcctct gtcatgaagc atggtttaaa gtatggtctc tacaagctgc 46860 atccgcttcc tcatcagcct tgatgtcatc tgcctcctgc agtcctcttt ctggccctcg 46920 ctccacggag acagctcacc agtgaccttc ctggttccaa atccagggga cgcttttctg 46980 ttctcgtcta attcaacctc ttagcaacgt cccaataaaa tgacctctcc cttcttcttg 47040 gagtcctcgt ggattccgtg gcctgcattg cacccgccag tccacctgcc tgaccccagc 47100 ctggcttccc caggcatcac cctctggccc ctcacccctc actgtctggg agcttccagt 47160 tcccctgctt catgtctagc agcccagttc ctgcatggat acccatgctc ctgtctctgt 47220 atcctataaa tgtctgccct caaccccacg gcccgttctc tgacgcctcc ttgagagacc 47280 aatctgtgcc tgctgctctg ctttttcacc tctggccgcg tggtttctcc tgcctcgaag 47340 cagggctggc tccacaggaa tagtcacagc gtccccactc ccggaagaac tgcgcgttta 47400 gagtaatgct ctgccgtcag tgccttgaca ttctccatca ttcttcaaca agaagcctca 47460 ggttttcatt ttgcactggg cctcccaaat tatgtagcca atcctatctc aaagccacca 47520 tcatcttatg ccctgccagt ctattctgct tgtagctgcc aagagattta aaaaaaaaaa 47580 aaaaaaaaat caaatcacgt cattcctctg tgtacagccc tctaatggct ttgcatctta 47640 atcagagtta aaaaaaaaaa aagtccttaa aatggcctgc aaggccctac atgatggagc 47700 caccattacc tcagcctctt acctcttgcc tttgccagtg tgctccagaa cacacctaga 47760 gccatttatg cctgctgttc cctctgcctg gcatgccctc cctccagata tccacttggc 47820 ttgttccctc acctccttcg ggtctttact aaagtctgcc tcctccagga agccttccct 47880 gaccaccctg tataaagcag caacactaag cacttcttgg ccccagcact catcacttct 47940 tgcgttgtat agatttgctt atctgttgat tatatgcctc cctctactag aacataaatc 48000 tcacgagggt gaggactgtt tcaatggggt accattgtgt ccccactgcc tggcactggg 48060 ctgccaccca gtaacaatga atgggtaaag gtaatgagag ggggagttag ggcaggcagg 48120 gagggcactt caaggaatat aaggtgtggc acagtggctc acacctgtat tcccaggact 48180 ttgggaatcc tcctaggcag gaggatccct ggaggctagg agttcgagac cagcctggtc 48240 aacacagcga gacacagtct cttcagagtt tttctttaaa aaattagcca ggtgtggtga 48300 cacaggcctg tagtcctagc taatcaggag gctgaggcag gaggatggct tgagcccagg 48360 aattcaaggt tgcattgagc tatgattgca ccactgcact ccagcctgag tgacagaaca 48420 agaacttgtc acagaacaaa acaagttagc caggcatggt ggcatgtgcc tgttgtagtc 48480 ctagctacta gggaggctga gggaggagaa tcgctggaac ccaggagttc aaggctgcaa 48540 tgagccatga ttgagaccct gtctctcaaa aattaaaaaa aaaaaaaaaa aggaacatgg 48600 gcaagcaggg agactgggag gggaaggaca ggggagtgtt ggagtaggtc tgtggggaat 48660 aaagtcagag ggataaagga gtcattgaac acaaggctga gccacagggg tgccaaggac 48720 cctcccaggg accatagttg gggaggattg aggggccttg ggggagagag accgaaaggt 48780 gaaagagggc ttcactgggc agctgatgtg accccatctg cccctcctgc caggcgccct 48840 gggtggtgga aggcagccgc cctcccgaag gttggccccc acgtggggag gtggagttcc 48900 ggaattattc tgtgcgctac cggccgggcc tagacctggt gctgagagac ctgagtctgc 48960 atgtgcacgg tggcgagaag gtacgcgtgg ggtaggcggg cctgcgtgtg tgttcatgcc 49020 tgcagacatg gccacagccc ttgtggggag cttgggtctt ttgagagcac aagtgctcca 49080 gccacatgtt tgttcggcct ccaggagagt cctggagatg cgcctttgac ctctcagctt 49140 ccccctcaga gccccttccc ttctccgccc aggtggggat cgtgggccgc actggggctg 49200 gcaagtcttc catgaccctt tgcctgttcc gcatcctgga ggcggcaaag ggtgaaatcc 49260 gcattgatgg cctcaatgtg gcagacatcg gcctccatga cctgcgctct cagctgacca 49320 tcatcccgca ggtaggagcc tggcatgggc tggccacact caccaacggc cctggaggca 49380 ggccccacct tgttctgtag ctttaggatg gagactggga ccccagtctc agaggcttgg 49440 gcaggtgggg agggacagac agcaggaagc agagccatca gtgagccacc cgtcatggat 49500 ctggaaagct cagacttacc ctgcccagtc aggccctgtc ctttgacctc ctgggccagc 49560 acatggggaa ggacccctcc aagaacccct tcccccgaga cattctgccc tggtcttttt 49620 gcgcagctct aattacattt cactttttct gtctcctccg gggtattttt tgtttctgcc 49680 gagtggacac tttggagtca gattagtggc tctggttcct gcttcaacag aggtcttcgt 49740 gattggcaaa gctgaggttt atcactcccc tacaggcaat tttctatctc tttggccatt 49800 gtgtcctctg gggagctgga aacagagtgg gaatgctgcc accttaatcc ctctcttctt 49860 ccctggacct ggggcctatg gctcctcata gggcctaagc tgcctccctc tgaggccacg 49920 ttgtatcccc aggaccccat cctgttctcg gggaccctgc gcatgaacct ggaccccttc 49980 ggcagctact cagaggagga catttggtgg gctttggagc tgtcccacct gcacacgttt 50040 gtgagctccc agccggcagg cctggacttc cagtgctcag agggcgggga gaatctcagg 50100 taaacactgg gagtgcagag gtcaggaact gcaaccctcc ctgggaaacc ctggcgggtg 50160 ctgggaaacc tgacaccaat gacacagaga tgaggccagc ccggatgtgc acagggctgt 50220 cctttcgtat tgagcatatt ccgtgtgcca ggcatggtgt actgccccgc cgactcctca 50280 cacaagcccc agcggtggtc catgatccca cttcaccggt cagggaactg aggctcagag 50340 atggtaaagg gcttgaccta agttgcacag ctgggagaag gcaggtctgg gatttgaacc 50400 agctctggga gattccaaaa ccctttgagg aagccctctc ccctccagag ctttcttaca 50460 gccccagatt ttatgtcctc agccactggg ctatgcactg gaggggccag tagtcacctc 50520 ttactgagtc taaaggttgg agatacctat acctgtgcta gctgtgtgat ttggggctag 50580 ttgcttaacc tctctgtgcc tacttttctt tcactctaaa aggcagataa taacagtcca 50640 aacctctttg cattatgctg cccaataaaa aacaaagcaa gtcatgcata tgaagctaat 50700 gtttttttct tatagccaca ctttttaaaa aggaaaaaca agcaaaataa actgtaatac 50760 tataacttat ttagcccaat atatctaaaa tattatttca acacatcatt gatataagta 50820 ttagaaatat tttgcgtttc ttcctacaag tttgaaatcc agtgtatatt tcacatttac 50880 agaatgtctc aatttggact agtcacattt caagtgctaa tagccacatg gggccagtgg 50940 ctaccacctg gacagagcag tgttagggtc agtgtgatga caggaaaagc gcttcgcttg 51000 gatgctcctg taaaatgtca gcttttcccc tcctcccttc cctccatctt ctcctcctcc 51060 tcctcctctt ccctattttc atttttatat tcagtccata ctcatgcacc ctccccagac 51120 ctcaaaaact aaaacaaggc caggcacagt ggctcacgcc tgtaatccca gcactttagg 51180 aggccaaggc aggtggatca cttgagggca ggagttcaag accagcctgg ccaacatggt 51240 gaaaccctgt ctctgctaaa cacaaaaatt agctaggcgt gatggcgggc gcctgtaatc 51300 ccagctattc gagaagccaa ggcaggagaa tcgcttgaac cctggaggcg gaggttgcag 51360 tgagccaaga tctcaccact gcactctagc ctgggtgacc gagcgagact tcgtctcaag 51420 aaaaaaaact ttacatttgc ccagcactta acaatattca aagcactctg gcctccactt 51480 tctcctttaa tctttaccat ggtcctgtgg gccagaaacg agcctccacg gtttgaaatg 51540 atttcctcgc agcagttcag ctggtaaggg gcagagcggg gactctggct ctgtcccaaa 51600 cctttccttg ctgtatcaca gccacctccc tcacctggac aacattcccc aaggcccctc 51660 attatcccaa gggtgggact cccttgccac ccacgcagcc cttaagacta aatatgcatc 51720 ttaagtggct ctcacttaca taaccacgtg ggggtggctg gcggacaaac atggtctctc 51780 cagaccctgt gccccatgac tgtctcttgc ttgatccatt cttctcacct gcttgctctc 51840 aacacttccc ccagagcatg ccccaccccg acacatgccg tgatcagaga cagaaatcag 51900 ctcccctcct ccctcactga gcttgtagcc actttaagta taacctgtgt cctgtgccag 51960 ttccaccata aatcagccct gagttctatc cggcggctta ttctgctgcc aaaaccttca 52020 ttagttgcgg gaatgggcca gggagagagc ccggacttta ctccggctgt ggtgactcac 52080 gcctttggga agggctgagg tatttgtcct tggatgtggg gatgctgtgg cctctggttg 52140 ggaacacagc ctcgttttgt ctgctggctc tggcttccag agcaggaggc tgaaggcgtg 52200 tgtcctgctc ctcctttacc tcctcagtga ccagacacaa agagtccccg ggtgttcctc 52260 tgccctgcca ttttcttgtc ccagaagcag agccctggcc tgtattccct atggggtggg 52320 aggtgactgc ctgaattgtg tgatattagg ctcagcaaga tggcatcgtg tggcctattt 52380 gcaaatatcc aagaagagcc atgcaagtat gttcttacta aggtgtaaat ggctgataga 52440 gtgaagcaga gaaacatcac ggcactagct gaaaagcaag gatggggaag aaagcaccga 52500 gagaggaggc caagggtgcc aagagcagac cagggatttc acaatgcctt ttagcactgg 52560 ctcattcccc aaggcccctc attatcccaa tggtgtccag acctctgctc cgttctggag 52620 ggctgggctg tggcagaaat gggagaagtc agacagaaaa ccagtcctgg gccactgagg 52680 agtgaaacag gtctgggaat gaggcccaga ggcaggtggg aggcccccag ctggaaatgc 52740 ctgccttctc cactcccagc gtgggccaga ggcagctcgt gtgcctggcc cgagccctgc 52800 tccgcaagag ccgcatcctg gttttagacg aggccacagc tgccatcgac ctggagactg 52860 acaacctcat ccaggctacc atccgcaccc agtttgatac ctgcactgtc ctgaccatcg 52920 cacaccggct taacactatc atggactaca ccaggtggga cacggaaacc tgagcaatgg 52980 ggaacctggt ggggccacct ggggcatcag gaatgggcag ggcagattag ggttatctga 53040 acaaggcaat gttcctggga ttgctagggc atggcaggca gagcagagtt tcccaagatc 53100 tggataaggg gcagaccaga gtggggtggc ctgggctcag gggtggggta tacaatgaca 53160 ttttcatttt tcttcttctt cttctttttt ttttttgaga cagagttttg ctctgttgcc 53220 taggctggag tgcagtggct cactgcagcc tcagcctctc gaagtactgg gattacaggc 53280 gtgcaccacc acatccggct aatttttgta tttttagtag agacggtttc accatgttgg 53340 ccaggctggt ctcgaactcc tgacctcaag tgatccacct gtctcggcct cccaaagtgc 53400 tgggattaca ggcgtgagcc actgcgccca gcttcaacaa tgacattttc taacacatgg 53460 ggaagggcac actgggctcc acaggcactg tctttgtgca caggccactt gcatcctgcc 53520 tcctccatga ggcaatgtaa ggggaactgg aggcttcatg ctgagtccca tcacttccta 53580 agaaacctgc tggcagagtg cctgcatgtc cctcacctta ttggtgtctc acagccactc 53640 tggtcacaga tgaagaagca actcaagtgg cagctggacc gtgacagcac catgaggagc 53700 tgagccttgt ggggagagca ctgtgtctgg agtcccaggc tgctgtgtga ccctgggcaa 53760 tttgcaaaac ctttctgagc ctgtttcaaa tgaaaatgat gcttcgtggg attgtcgtag 53820 tcaatgaggg ctgggcacag tggctcacac ctgtaatctc agcactttgg gaggccaagg 53880 agggcggatg acttgaggtg aggagttcaa gaccagcctg gccaacatgg agaaaccctg 53940 tctctactaa aaacaaaaca aaacaaaaca aaaacaaaaa tttgccggat gtggtggtgc 54000 atgcctgtaa tctcagctac tcgggaggct gacagagaat tgcttgaact caggaagcaa 54060 agattgcagt gagccaagat tacgccagga cactccagtc tgagtgacag agtgagacgt 54120 tgtctcaaaa aaaaaaaaaa atggtggcca acgcggtggc tcacacctgt aatcccagga 54180 ctttgggagg ccgaggcagg cagatcattt gaggtcagaa gttagagacc agcctggcca 54240 acatggtgaa accctgtctc tactaaaaat acaaaaatta gcctctcatg tggcaggcac 54300 ctgtagtccc agctgctcag gaggctgagg caggagaatc acttgaaccc aggaggcaga 54360 gtttgcgcca ctgcactcta gcctgggtgc agagcgagac tctgcctcaa aaaaaagaaa 54420 aaagtcaatg aaagatattt aaactgcagg tgatcctggg aaatgacagt gtcctcccca 54480 gccccttgct ctaattcttg cgctaggccc tccaaggatg aggggagggg ccatgccctc 54540 agaagcttgt ggcttccttg gagaggcaga ccactccctc attgtgccag atgtcaaagt 54600 gtggtgctgg aggtcgagga gagagggctg ggtgactcag aagcctcacg ggagtgaact 54660 ggccctggcc tggcaggctg tgctccctag aaactagagg ggaggaggag gcaggaggct 54720 cagacaagtc ttctttgaag gagtatagtg ggaatacccc aacaggcctt cactcactca 54780 agaaacactt gcaggacgat ggagtgggaa gggtgccatg gacagggcaa tgggtcagac 54840 cttgctctct tggaagtgcc cccatgcagc cagcagtgtc ttgggagcca agctgagaat 54900 gcctgatgct accctctgtc tgttccatcc ctctcctacc ctcacccccc actcccattt 54960 aggaccccac tgggagaagg gagggtgggc aggaagtgct gagccctggg tttggaggag 55020 ggacagggct gggctgagag gacctgttcc caggcctaac caaaactgtt tcattcacca 55080 gcagccctag ggtgaggggc ttggatggac cttggaggtt gggagttcat tcattctagt 55140 ggaacaggca gaaattaatc aaataatcat gtgtaaatag ggcccatagg aaggacgcaa 55200 aggcctgtgt gtgcaggcca gaaaaaggct atccacacag ggtggccagg acactttctc 55260 ctgtaaggaa gggatgcacc agccaggcct gaaagaatga gtaagagttg gaggatggag 55320 gtggggcaat aaggtaggga gcgagctgaa aattgcaggc aaaggatata acacatgccc 55380 caaggcagga gggtacagga ggctggagtg cgtgggaggg aggcagtaga accaagatgg 55440 gggtggagaa caggccgcac tctgctgcac tttgaggacc atgggagagc attcagtcct 55500 tacccaagag caatcaaaag ccgctgaaga ccttgatttt ggagtcaggg ttgggatcgg 55560 cgggagggga gggggggcgg tggccaggca gtgatgtcac agacacagtc cttcccagga 55620 cacatctggg agcccagtag gctgagaacc agaatgcagt cagccccctc ccatggagga 55680 gcacttctcc aggctgggga gagccccttc ccctcctgcc gtaccctggt ggagccagcc 55740 cactggcctt gtaccaggtg cactcggtga gtggttggtg ggagattcta accctgggct 55800 caggcctagc tgtttgtgtg tgagctggag acccaccgag cagcagcagc agcagcagca 55860 gccgcagcag ccgccaccag atttgcagcc caagccccag attccagtgt cagcctcgct 55920 gcagctggtt tcctgccgtg tgcttttgtg agccgacaca aagcagatgg atgtgcacag 55980 agcccagcgc acaggcccat ggctccctgc gcacagcctg ctgaagtcct gtgaccccgg 56040 caaggggaag ggctcattag ggaaggtttt cagagccctg actagcagag atgaatagga 56100 ccttgtgttt gatcccagaa actgcttcac ttgccagaac taacagaatg gctaaaataa 56160 ccagccttgc aagtgtgcac atgtggtgcg gtggctgtgt tgggtgggtt ggcatgtcac 56220 tgtgggcctg agcaagtacc cagaagagca ggattagacg atgtgaccag gtcagggctg 56280 atggaaacct gaccacttct ctcttttttg actagggtcc tggtcctgga caaaggagta 56340 gtagctgaat ttgattctcc agccaacctc attgcagcta gaggcatctt ctacgggatg 56400 gccagagatg ctggacttgc ctaaaatata ttcctgagat ttcctcctgg cctttcctgg 56460 ttttcatcag gaaggaaatg acaccaaata tgtccgcaga atggacttga tagcaaacac 56520 tgggggcacc ttaagatttt gcacctgtaa agtgccttac agggtaactg tgctgaatgc 56580 tttagatgag gaaatgatcc ccaagtggtg aatgacacgc ctaaggtcac agctagtttg 56640 agccagttag actagtcccc ggtctcccga ttcccaactg agtgttattt gcacactgca 56700 ctgttttcaa ataacgattt tatgaaatga cctctgtcct ccctctgatt tttcatattt 56760 tctaaagttt cgtttctgtt ttttaataaa aagctttttc ctcctggaac agaagacagc 56820 tgctgggtca ggccacccct aggaactcag tcctgtactc tggggtgctg cctgaatcca 56880 ttaaaaatgg gagtactgat gaaataaaac tacatggtca acagtatata cacagtagtc 56940 tttttgcact tgttcacaag gtttggggat taggatcttt ggaggaggcc aagaggaaga 57000 ctttctacac atgtacatgg ttgtagttac ctgaacttca gacccaagag ctcttggctg 57060 caaatattgc cttcacagcc aaaattccct gggtaattgc cagtagctcc tgctctgctg 57120 tgcagatatt gtaaaacggt gagaaaggcc ctgaaatctg acctggggcc tcttgggaaa 57180 gctgctgtga acacctccac gttaatgtca tccctcagcc ctctatgcct gtttctctag 57240 ggactgagaa gtgcatgatg cttttacttc cttgctcatt tcgaagtctg ttccagacag 57300 ttcctataac cagtgaggcc tccaagtcat tcattttcct cagtctagcc aaagctgaat 57360 gtgtgagcac aaagaagccg agaggccacc tcctgcccag agagaagcca cccacactcc 57420 caggttggca gacaagatgt gaggggtgaa ttaaatttgt tttcttgagc aagcca 57476 <210> 29 <211> 59859 <212> DNA <213> homo sapiens <400> 29 gttataactt ttgtaattgt ctcacaccca cagtacgtgg gtattctgtt ccatattttt 60 catttttttt ttttttttgc tttgcatttc agttttagaa gtttgtactg acgtatcttc 120 aagcttactt attcttgcct tggctgtatc cagtctattg atgagcccat taaaggcatt 180 ttttcatttg ttctattgtt ttttatttct agcatttcct ttctattctt tcttagagct 240 tccatatctc tgcgtacatt acccatgtgt tcttgcatgt tgtccactgt ttccttagaa 300 tccttggcat attaatcata tttatttaaa atttttggtc tcaaattcaa aaatctctgc 360 catatgtgag tctgattctg atgtttggtt tgtctcttca gactgtgttt tctgtctttt 420 agcatatttt gtaatttttc tatcattgtt gtcattgttg aaagccagac atgctgtatc 480 agttaaaaag aacttaggta gatgcgcctt taagtgtgag gtttcatgtt tatctggcaa 540 agaggtaggc tttgttactg ttcgtggtgt cagaggctaa aatttcctac tgtgtccttg 600 tttttgcttc ctatgttgtc tttggctgtc cccagagact cttaaaatag ggtctgaggt 660 ttgagttctt ttagctgtaa tgccccgtta ttacacagga gctcttctga tgtggtgata 720 aggtgagggg gagaggagga ctttctgcag tcctatgatt agggctcaag tcttttagtg 780 agcttgagtt gagtatttcc cttctcccct gtggaaggct agagctgacc agagttggta 840 atttcccttc ctccagattg gttagccttt ggtagattca tctggttagg ctctgataga 900 gagtttccct tgaggccagg tcttgttaag aagaacagag agccctgaga gtatttcacg 960 atggttactt accccttctc cctggcaaaa gcaaagcaga tttttctcag atctttacag 1020 tgagaatctg acaggattca cagaggtaaa actgaggtaa gtattgaggc ccctctcaga 1080 ctgagcctcc ttggagtttt ttaactctca agctagtctg cactgagcct ccagcaattc 1140 cccaattaca gtttagtgtt cctactgatg ttggctccag ctgtgaaact agcttcagct 1200 tctggcttct gtgcctgggc tctgctcctg gtaaactgtg attctctgaa aagctgtgat 1260 tctctgtatc tatctgtctg tctctctagt ttttagggca gtggtttttc ctgtgacctc 1320 aattctctgg tggatctaag aagagttact gatttcagtt tgcttagctt ttttttttct 1380 tgttgtgagg atgggagtga caacttccaa gctctttaca tgttgaacag gaaactgaaa 1440 gccccttggt gttcctttgt aaattcatct taaaaatatt tatcataatt gaaaagtgct 1500 aatatcaaat tttcagtctg tttatattcc ccctaaactc agataaatat acattttatt 1560 ttgtgtgtct gtgtgtgtgg gttttgttgt tgtttgtttt ttgtgttttt ttttaagata 1620 tagggtcttg ctctgtcaag gctggagtgc agtggcacaa tcgtacatct ctgcagcctc 1680 gaactcctgg gagaaagtga tcctcccgct ttagccttca gagtagctac gactacaggc 1740 actaaccacc aagcccagct aatttttaaa attttttgta gagatgggag tttcactttg 1800 ttgcccaggc tggtctcaaa ctcttggcct caagtgatcc tcctgcctca gcctcccaaa 1860 atgttggaat cacagatact ttgtgtcttg attcttgaaa ggaaaaaaca aagattttta 1920 atgcctctta tcttgtacgc actttccttc caaacaatac ccttttgctg ccattgttct 1980 cgttatgaat agcttaaaga aaaagaaaca actaagggta gtaataggcc aggaatcact 2040 tactgaatac taggtcttct tgtatagttt gataccctat aaattgtgtg catctgatgc 2100 atttcacctt caaaaggctc aatgctctgt attatttagt agtaatcaaa atttcaagtt 2160 ttacttaacc tcctgattca ctgcccaatt tcctaataaa tacgggctaa gggtcaatgg 2220 ggtcatttgc aagtaatctt gtagtctact cagaaagttc tgcaaagtta gaaagtgatt 2280 aaatgactgt ttgttaagat atacttacat agtaataacc taaatgcatt tgttaagtgg 2340 ttgtagagag agggatttaa aattttatcc tatatgaaat tttccttttt ggtgtctgtt 2400 atttaatagg attgtttgaa ttaggggata ctatttggtg cctttgtaac tatatgaaaa 2460 ttagttggtt gaatattact gctttccatg ttcatattta tatttgtata gacatatata 2520 tatatacaca tatactactt tcctttccat tttcatattt atatttgtgt atacacatat 2580 acataaacat atattttata catttttgaa aaggaaaatt aacttaaggg catatttaat 2640 gaatattcaa aaattttttt gctgatcaaa ttatcattct gctttaaact tttgaaatga 2700 tccaaaaaaa ttttaaatga cttagattta ctgttacaaa atgcttgtct tttgatgtca 2760 caaacattat atactataat cactggccag agataattgc tataagtata atgaaaaggg 2820 aaatgatgga agatctctgc agctatcctc ataaatgagg gtgggaacac gatgggcagt 2880 tccaaagttg aaaatagaga atatatgtgg atttatatta acataattgg tattcttgga 2940 tagttaaaaa tggctaaact gtaggagaag cccgagtaat tactgttaac agaggaataa 3000 atttgagggc aataataatg atgataggcc aggcactgtg gctcatgcct gtaatcccag 3060 cactttggga acccgaggcg agcggaccac ctgaggtcag gagttcgaga gcagcctggc 3120 caacatggtg aaacctcgtc tctactaaaa atagaaaaat tatccgagtg tggtggtgcg 3180 tgcctgtaat cccagctact tgggaggctg aggcaggaga atcacttgta cctgggaggc 3240 ggagttgcag tgagccgaaa tcgcgccact gcgctccagc ctgtgggcca gagcgagact 3300 ccgcctcaga ataataataa tgataataat aataacgcca ccaacaatac taagagctaa 3360 catttactga gtgcttacta tgcaccagat attgttctaa gtatacattt attatctcat 3420 ttaaccatcc ataatactgt ggtatagaca cttttatatc cattttataa ataagtaaac 3480 tgagttatgg agagattaaa cgacttgcca gtaagattca aagcctgtgt acaagctcac 3540 gcttgattct ggagccagtg ttcttaacac agtatcttga gaatgttaaa ctaaaaagtt 3600 tttaatttac agtattcttt ccacaattaa aaaagaaatt atgagtaatt atttttagtt 3660 ctttcttctc ttcaggcatt tcccatggtt cttttcaaga cataatacat atcatttagt 3720 gttgtagatc tgaaaaaaca aaagtagcgt gaagatcaaa aattttctaa agagacggag 3780 tctcgctacg ttccctaggc tggaacaccc aggcttctcc agcctcacac ctctgagtag 3840 ctggaaccac cctgtccgct aaggtcaatg tttaatcgta tctttgtagg tctactgacc 3900 agttaaaaag aggtgctgta tacattggtt gttgtcttgt cagagtttga tgcttctata 3960 tagaccattg tttttacatg ctaatacaat tgaaagccac tacagatatt tatatttaca 4020 acccaaagct aggttttaac aagaaactca taaggcaaag gtgagaagta aaataattta 4080 gcgccaagtg gagatatatg tgcaatgcta ctttgttggg ctcaaaacat atttttcttt 4140 tagaagactg acaggcttga agtttatgcc tccaaagaca aaagtgatta tgttttgttt 4200 agtagcttgc aaagttgcca aaggccattt tttctactct ttccctgaaa ttggtttata 4260 tgcttattaa agtcatttat acctatttgc aaatgcttaa catagtttca gattttaaga 4320 tttccctgca actttatttc ccttgaagtt tacagcaaca ggagttcatt tttattttta 4380 attgcattta ttcagtaagt aaactccgcc acagaaaaac ttagtagaca aggtgagttc 4440 ccctgtgctc cgtggcaaag agtgcggtgg gtgacattga cccatggtta ggtaatctgg 4500 taaggaaaga ccccgttgta acacatctga gcaacgagac caaaggaagg gcttgctgcc 4560 acgaggcgaa gtctgctttt ttgaacagag agcccagcag agttgggcgg caatcgtgcc 4620 cagcactgag gccgaggaga aagagagcag gagcattaca ttactgcacc aagagtagga 4680 aaatatgatg catgtttggg accaggcaac cgaaatccct tctcagcagc gcctcccaaa 4740 gccgggcacc gccttccttc ggagaaggcg cagagtcccc agactcgggc tgagccgcac 4800 ccccatctcc tttctctttc ctccgccgct aaacacagac gagcacgtga gcgtcgcagc 4860 ccgtcccagc tgtgcctcag ctgaccgcct cctgattggc tgagagcggc gtgggctggg 4920 gtggggactt gccgcctgcg tcgctcgcca ttggatctcg aggaacccgc ctccacctca 4980 ggtgaggcgg gcttgcggga gcgcgcgccg gcctgggcag gcgagcgggc gcgctcccgc 5040 cccctctccc ctccccgcgc gcccgagcgc gcctccgccc ttgcccgccc cctgacgctg 5100 cctcagctcc tcagtgcaca gtgctgcctc gtctgagggg acaggaggat caccctcttc 5160 gtcgcttcgg ccagtgtgtc gggctgggcc ctgacaagcc acctgaggag aggctcggag 5220 ccgggcccgg accccggcga ttgccgcccg cttctctcta gtctcacgag gggtttcccg 5280 cctcgcaccc ccacctctgg acttgccttt ccttctcttc tccgcgtgtg gagggagcca 5340 gcgcttaggc cggagcgagc ctgggggccg cccgccgtga agacatcgcg gggaccgatt 5400 caccatggag ggcgccggcg gcgcgaacga caagaaaaag taagcccatt ccctcggccc 5460 gccgccttct cccccggcga ccccgcccgc ctgcccgccc tgggctcctg ggccggcctc 5520 ggcgttaatg ggattggggg gggcagcctt tttgtttctg ctgctgctcc cctcccctct 5580 cttcccccaa cctcgccggc cgggctcccc cgctgtccac gtcgccatct tgtcgtgggg 5640 ggtgggagac gcctcgaaag tgctttcagg ggccggggtc tgagccctgc ttgccctccc 5700 cgccggccgt gggggcctcg cgccgcccac ctacccgcct caaaaaccca gcctgctctg 5760 tggccccatc cggaggggac tttacccagc ctgaaaaccc cgggaagaga aatgagctgc 5820 agctcggtag ccgcggtttg cacccggagc ttccgctcct tcccgccccc atcctctcca 5880 gttccattga aaactcggcc ctggggcgga ccctgcacgc tggtcctggc tttccagtgg 5940 acttggggcc ttgagttccc gactgaggga ctcgcgtggt cggatgcgat cttgtcctgt 6000 agttgtccag ccgtcgcggg tgtctttgcc tttgtgcatt agggatttgc cgcgatggcc 6060 ttaagatgcg aactttttag tttgcacgtg caggttttgt ttcgttttaa tcgccttgaa 6120 aaacttgcct agactgagag tcagagtaat gggaatttag ggaaatggca acattttaaa 6180 gagaacttca gaattggata cttgagttca tatcacctgt cacgagaacg cagatattat 6240 aaatgaatat atgcctcatt cattcttcaa ataatgaaaa tgtaggggct ggttaaattt 6300 aggcagtttt aatgatactg aaaaaagtat atgatgagtg aatgaaatgc ggcactaaaa 6360 tgttgcaaaa attttcgaac tctgtctcat tttcctgaaa ttgaagtata ttaaaggaaa 6420 accgtcaaca tatatctaaa gtaagtaatc actcggttag aacttaatgc aagttttata 6480 aatcaccttg aagtttgagt ctaaggggta cattagagat taagaattgt gagttggacc 6540 agtggtgtta agagcggact cccccatccc ccaacacaca cacaattttg cccactttgg 6600 cattttaact tttaaggaaa tcacttaagg aattgaagat ttagagtaag agttttggtt 6660 agtagactgg ctttgctgtt aaatccttcc actcttctgg cagagagatt aatttcccta 6720 atcagtatca gcagaagata aacttgttta tattcctgct gttttgtaga tcccttctcc 6780 tggtccttct tcaatagaat attaaattct tagtttgtat acagcagaga aggtcactta 6840 taaaattcaa aaagtgagca aacaggtcta gattaattcc aagagttacc aggaattaat 6900 tgcagtttat tttgcggagg tgattacagt gcttttgatg aaatgataaa gctgctatat 6960 tgtaaaccta aggcagatta cctctgtgta gtgccagttt tctatcctta ttatatattg 7020 aatcatactt aatacaatgc attaaattat gtaccacttt ttttatatac agtatcgaac 7080 tcattgtttt gccattcatc cgttcagaat atcagaagca gttttgaaac gaattaataa 7140 attagctact gttcatcagc cccaattcta aataagctct tagattttcc tcagcccatc 7200 tgttactttc aaaattttct catttgaaaa cttggcaacc ttggattgga tggattcata 7260 tttcttagta tagaagttct tgatataact gaaaaattaa gttaaacact taataagtgg 7320 tggttactca gcacttttag atgctgttta taatagatga ccttttctaa ctaatttaca 7380 gttttttgaa agataactga gaggttgagg gacggagatt ttcttcaagc aatttttttt 7440 ttcattttaa atgagctccc aatgtcggag tttggaaaac aaatttgtct ttttaaaaga 7500 aggtctagga aactcaaaac ctgaagaatt ggaagaaatc agaatagaaa atgggtatgg 7560 ttatgatact gtagatttaa cgcaggacat ttcatgttgt tcctagttat aggggctgaa 7620 cttatttaat agcacgtgca ttttgatttt tagattttta agggaatgtc aagagagtaa 7680 tgattctgtt tcaggcttca ggccagactc cttcagagtt ttccaaaaca aataattact 7740 gaatcattaa agtaaaattt ctgagaatag atattcctta atttccttca ttaactttgg 7800 ccattaaaag tcaagaagct ctctcattta ttagcaaact tttctcctta tgattctatt 7860 ttgattgtcc ttttgtttga ggaagcagca tatggtggtt aagagcatag gatctagagg 7920 cagatacctc tgagttaagg gtcccagccc ttcacttgtg agcttgagca agttactgaa 7980 tgcctctgag cctctttcct ccttttgaaa tgatgataag aatagcagcc atctgagcag 8040 ttattgtaaa ggttaaatga gataatgctt gtgaagcact tagcccattg caggagtctt 8100 gatgacactg tgtacttgaa aatagatgtt acctgttaaa attcttgttt aaacttccac 8160 aactcttaaa actctttttt gctagtcctt ccagctgttt cctttagttt cttttctgtg 8220 tcttcatgca tcttttctat ctcctgaaag tgaaaagact aacattggat ccagagcttg 8280 aaaagcgttt ttttcctgtt acaatgggca aaagagtaca tccttgggtt atattggcac 8340 ctagtatcag ttatttttct tgagcatctg atctgctctc tactctagtg gaggcctcct 8400 gcttcacaat tgctcacccc tgtgttttct ccccaaatag aatactgagt ttactctgga 8460 ctctagagtc aaacatacac agtattctag tcttactgtt catttaagca agatatgtgc 8520 aagacactgc attcttagta ctggcagtaa gttaaaacat ttttcgtctt gatgccaaag 8580 tttagacaat tttataaaaa ttaacctttg taaaagataa tgagttgata aaatattctc 8640 agtaaagcag ctacgtggta gaaaaactgt cctttgctta tgagtttctc cagagttaag 8700 accattgggt tccatctgaa ggcaagactt caagcttgtc ttactggtct gttttgtggc 8760 tcaatttgta tgaagtctat gcactcttcc acacgtgtgt atttactgaa ctatcgagtt 8820 attttagact gagaaagtat tggagttcat tcctacggtc cactgcagag caccttgtgc 8880 agtttggaga atgtcaactt ttctacctgt taacttccat tgtctttact tttaacgcca 8940 ttgtctgtga ctctaatggt gtcacggctc agggtttaga ttttgtggtt acattctatt 9000 cttgtatgtc aagagtggtg tatagaaagc tgagggggat tatttagtct cttgactgat 9060 tttttttttt tttctgaaga actcagttta ttatgtttgg tggtgaaata aaaattgatg 9120 tgcatggatg ttaaagattt gggttaaatt gtgtgttcat agatgccttc tcttagtata 9180 taatttttta aatttagata cttaaaatac tgtatccctt tatctaagat taacataagt 9240 ctgtttctta accaggataa aaaaatctaa atttaaatgt gatgttggat gagtttccaa 9300 tcaagaaatt gattttttaa actttgtgac tagttatcca gtgggtggat tttacccagt 9360 gtgtgtatgt gttttctgct taactctgga aggttagaaa gagaatttga aactaagaca 9420 agccaagctt cttgttgctc agtatttttg gtaaaaatat ggtcagattg tttaaattaa 9480 ctataggctt tggaatttta aaaataatta tatctcttgg tctcttgaca catcaagaat 9540 taactgtttt gtatatgcgt tgagtattaa tgttcatgtt ttctgcagta gaaatttata 9600 aacccttatt tatttgccag acatgatccc tttagagaaa tctagtatct aaaacctgaa 9660 tttttaaaac aaaatttaaa atttttgttt cataaaaaca aaaatgtgat tacctcatgg 9720 cttttttctt atagcttttg attgtttttt aaaatcgtag ttcaaaaaca ttaacctaaa 9780 atttaccatc ttaaccattt ctaagtactg ttcagtagtg ttaagtatat tcacattgtg 9840 ccactaactt ccagaacttt ttcatcttgc aaagctgaaa tcttacccat taaacaactc 9900 ccaatttccc cctctcctca gcctctggca accaccattt tactttctgt ttctgcaaat 9960 ttaactactc tagatgcctc atataaatag aattataggg ttttaatatt tttgtgatgg 10020 gcttatttca ctttgtgtaa tgtcctcaag gttcatccat gttgtagcat gtgtcagaat 10080 ttccttcctt tttgagtctg agcaatattc cattatatgt tccatatttt gtttctccat 10140 tcatccagca acggacactt gggttgcttc cacatcttgg ttattgtgct gctctgaaca 10200 tgagtctgca aatctctctt tgaagctttc actttttttg gatacatatc cagaagaggg 10260 atgctggatc atatggtaac cctttttaat tttcaaggaa ccaccatatt gttttctata 10320 gcagttgcac cagtttacat tcccaccaac agtgcacaag ggttcctatt tctccacatc 10380 cttctaaaca cttgttttct ttctttcctt ccttctcttc tctttctttc ttagccatct 10440 aatgtggcaa agtggtagcc atctaatatg ttgaagtgat tgtttttaag ggcttgtttg 10500 tggataatta accagctgaa agctaactac agtttgccag tggaagcttt aactgaaagg 10560 agagtaagta cctctaaaag gagaattcaa tttttctagt gacttagatt tgttatgcca 10620 gtactttttc acagaaacac tttttgggta aaatagtgta cacctgttct attgttgata 10680 aagcccaatt taattaggaa atttgttctc taagatttaa aacaataatt gaaataatgt 10740 atttttatta aaaactgttc ccaagatgtt agcttttagc tgttctggtg atctcaactg 10800 ttatttatga gtgtttcttt attttaaaat ttcaccttaa ccggttacag ttttaaccat 10860 aaagattatt tcaacatatg attttgaaaa tttattatct tgtaaatggg aaaatgtagt 10920 gatggaacat agtttactgt atgtagttct tcacttgttt gaaaagtcac aatatattta 10980 ggcaaattaa tttaaaagtg tctagtattt aatattgcaa ttttcactca ttaaggacag 11040 gtcccccgtg tttccccctt ttttttttcc aagtagtttg ggaggatttg tttttccagc 11100 tgaaaaatac tatggttaaa aataaggttt aaaggcgaaa gttgaagtct ttgagggttg 11160 ggatacgttt ctgttcttaa gagtcttgta aattcagatg ctaagcaaat ttctttaaaa 11220 tgatttctac cctccccctt tccattataa aactggatat gtttcagtgg accaaatccc 11280 aagtaggctg aatttgaaat ttgtgggctg ggcgcggtgg ctcatgcttg taatcccagt 11340 actttgggat gccgaggtgg gtggatcacc tgaggtcagg agttcgagac cagcctggcc 11400 aacatggtga aaccccatct ctactaaaaa taccaaaatt agccaggcgt ggtggcgggt 11460 gcctgtaatc ccagctactt aggaggctga ggcaggagaa ttgcttgaac ctgggaggcg 11520 gaggttgcgg tgagccaaga tcgccccatt gcactccagc ctgggtgaca gagcaagact 11580 gtgtttcaaa aaaattaaaa aagaaatctg tggtgtgaat actggtacgt ggtgtacaca 11640 gtgagctctt aataagtatt tgaattaaca aatgagacaa tgattgaata attggatgaa 11700 caaagagaat gcaggttttt aaaaggtttc tttagaaata ttgtcggccc ggcacggtgg 11760 ctcctgcctg taatcccacc attttgggag gccggggcag gtgaatcacc tgaggtcagg 11820 agttcaagac aagcctgacc aacttggaga aaccccgtct ctactaaaaa tacaaaaaaa 11880 aaaaaaaaaa aatagcagga tgtggtggca catgcctgta atcccagcta ctcggaggct 11940 gaggcaggag aatcgcttga acctgggaag cagaggttgc agtgagccaa gatcgcgcca 12000 ctgcactcca gcctgatgac agtgtgagat gctgtctcca aaaaaaaaaa aaaaaaatta 12060 aaaagaatgt tttaattctt tagttccctg tctgagattc actgattggt aagaagaaag 12120 ttaaagaatc tcctttgact ttttttgata tagatattta aattctatta ctttatagta 12180 aggttggggt ttattttctt tgctttataa tagaagagca ttgattattc tctttgcttt 12240 ataatagaat accatttaaa taggagttcc ctgagtgtgt ttacaatcat ttgatctggc 12300 taaactattt taatgttaat gaaattttaa aattttggag gaaaaaattt aaaaactaca 12360 caggtgcaca aagaaataaa aatcacctgc tttttcacta tgtagagacc attgtctact 12420 atttctcaat tctgtgttac atctgtatgt taataactgt aggattaggg actgagtact 12480 gtttttaacc tgcttttaaa aaatttacat ctacattttt tcccatctaa atagtgagga 12540 agagtatcag aattttgtag gcttgtggtg atggttaaat tagataatat taatgttggg 12600 tacttaacat aatatatggc tcttaatact ctccagattt cagatatagt ctgttttacc 12660 attactgcct ttttatcaaa cctattctca aaaaagtgag aaaagtgctg agattacagg 12720 cgtgagccac catgcccggc ctcatggttc tttcttaata ataaattaga agaagtagaa 12780 ttacagggtc aaaaagtatc cattttaaag ctttcaatgt aattgcctgt ttatcttcta 12840 gaaagtttga cctagttgta ttttagagtg tcattttctt gaactttatc atcattaaag 12900 ttttaaattt ggaacactgg caatttgata agtatattag gattcttctt attgcaagta 12960 gcaaaataca actcaatcta gtttaagagg ggaaaatgta gtcattggct aacacaatct 13020 aattttggtt taagagacaa atctagagtc tcaaatgatc tcagagtgta ataatccctg 13080 acttttgtct tgatattact tggcttgtat acctttgctc tatttgcatg ctggccttac 13140 tctgccactg acaggctgtc tgtatggtgt ggaagaggac ggctagcatc cccatacctg 13200 catccataca gtttgtaata taaaaaaaaa aaaagtaaaa aaaactccct ctctcttcta 13260 gtgtctatat atcagtttcc tagaagaaaa cgttttgccc tacttggcca tgtgaatgga 13320 gttccctgat tacatgagtc aaatatgtct tattgtagca tatttgatgg tcttcttgta 13380 gaatattatc ttactataca cagaactctt gaccagtaat taatgggcca tgagtttttg 13440 ttgcaagtca tttgaattca tattctatag ttttctacca agtgtagtca ttctgcaagc 13500 tgttcttgtc atgacttttg ggaagttgag tatttcttct atgggttagg gttttcatct 13560 caagaaaaag atgatccttt tctctactaa atatgtgtta agatcacaca tttttctaga 13620 tcgtttagct ctactgtgtg atcttacaca aattgcttta ttgggatgat aagaataatt 13680 gccttatagg attgttatga gaatgaaatg atacatcaac tcatatgaaa cactcagaac 13740 agctcttggc acaaagtaag ggcttaatta agtagaaact atccatatat tcataatatt 13800 atagtattgg ttaagttgtt ttcaacattg tttagaatcg ctcaagcctt ctttgtgata 13860 atctgacgaa ggctattcac caccagtgag taaataatag tggcagaata gttactgatg 13920 cttttccttt acttggtttt ttttccataa acatctggcc tttgcagact aaatactggt 13980 ttatgtatag acatgttatt ctaaaataat tttccatagt ggtaatacta aaggaagaaa 14040 aatgttctca aagctattta tttgggatgt taaaggaggg ggaaattaag aaagcctaca 14100 tttccatgtc ctttgtgtcc agaatctcat taaatgtctt ttaacttgtt agcagaggaa 14160 agttggatat tgcctgcctt tgtagctaac atagttaaaa tatttaaatg gttatagtgt 14220 caaaccagta gtcaaagcct tcactgtgaa tggatgaagg gatattttct tgaataattt 14280 aagttgactt atttcagtgg ttcaaaaaat ttcttcaacg cttaaccatg actcaggcac 14340 ctaactatta tactatgtcc tgtaacagat tgttgtgcat tcatttattc aacaggtatt 14400 tgtgcagcta atttattgag tacagcattg aatcgttgat ggcttaggcc acagttgaac 14460 attccatttt ttatgttcat tcattcattc atagcatatt ccatttttaa attttcagtt 14520 cattgcactt taaagtttga ggttcttgcg aagtacagac ttttgggttt aagttttgtt 14580 atttaatgtc aaccaccaca ggcgcattgg ccagtctgct tttagaattt tcagacatac 14640 atacacaaaa cattctcaca agacaatcta cttattttct tttttattcc tgtgtttctt 14700 aacacaggat taatgttcag atctcttttg gagcaaaata atcctctgaa tttttgagat 14760 gtacccagtg acctcagtct gagtatgtat actgcattaa aaaatgtaac cttgttcctt 14820 ttagtggtca tttggtaaca gtttgatcat aaacaaatgc agcctcaaac acagaaggct 14880 tgaggcaagt atacagaact atggagagat catttagatg atgtagaata tgccttttct 14940 ttttttacaa tgccaccaaa atgaaaacac ggttttaaaa attctcatag agtgtaactt 15000 caacactgct ttaactctat taaacaaagc actgccatgt tgtaattcct atttattact 15060 ctctggagtt gtataaatta ccaaatccgc cttttgtttg atatcctttt caaatatctg 15120 agggtagcta tcatgtttct tccttctatt cttaaaaaat agtcccaaat ttcttgaatc 15180 ttttaattta aaaattatat attgagcatc tgatttgtgg aaaggcatag gccatattaa 15240 aaatggggct tcatattaaa atggggaaaa gggtggagat tctcaggtgg aatctgagat 15300 ctgccacaca ctaatagtgt tacctaaccc tttttaaaga caaagaaaca ggatcagaag 15360 gtcactttgg aaaatttatt tggtaatatt ggataggatg gattagtata gttggaaaac 15420 agagactctt gctttaggag agctgctcct ttgtcatttc cagaatctta atcatggtca 15480 aggtttagag ctaaatattt aatagaagaa gtctttaggg tatgctttct attgtacacc 15540 cttatttcaa tacatgtgtt ttttcctgtt atgtaagtac tttattatta tttatgcatc 15600 ttctattaaa gttaagcaaa taattatttc aaggacacat tcttctacat acacacaaag 15660 tttagggtca ctgaccttct taggttctag tcttagatct gttaccatct aagagcatat 15720 aaataaggga aacagaaaga aaaggattta caagctgaga aggaagcaat gcagagaaag 15780 aagagtgata gagtaggtaa tttggggaaa gtcagtgata cacagctctt aaccatgaac 15840 agtgattctt cactcttgaa tgtttgtgac attcatgaag gtattaaaag ctgactttta 15900 aaaaattgtt tcagagaact ggaaaaaaat tcagttgcca cattcttcct taggtcatct 15960 ttgaactcta ctcatgcact tacgtgttta aggcaaagtt ttactaaacg cacacttgtt 16020 cttgctggct tattgacttt tactgctagc ttcttattct tagcaattat acctcacatt 16080 acatagtatt gtgaaactca ctatattcag tgttttgcct gacaaacatg gtatgttata 16140 ggatgtgtat tcagttatag ctaaaaataa attattctcg tttttcaaaa tttgctggcc 16200 tacctgttaa gcttttgctt taagacctgc taatgtttct caaacttctg tggttaaatc 16260 acctgagtgt ctagttgctc tatggattcc cagggaccca ttcgccagag attctgattt 16320 ggtaattttg ggatggaact cagggatctg taaattttac aagcactcag aaatgaaaca 16380 tagactttaa acagctaaga gtgctcatca ggattatgtt gatattattt tttaaacaga 16440 tgtgccaagc ctttaatttg aatttccagg gttgggattt ggccttctat atttggggga 16500 aaaaagttct attgatgatt gtggatatat accacaggtc aaccattgaa tagtctagtc 16560 agtgtagtta gtgtatttta taattactaa gttctaagta tgtggtgtat taatgtctta 16620 ggaggtggat atatttcctg tatttgtaaa gcatttgggt aggtttttta aagagaaaag 16680 tatgtaacaa actagttttg agcgttgctc ttttacttct ttgggcattt ttgaagaaca 16740 cgttaagtat cttcttagag cagaggggct cagagtggtc cccagattat catcattggt 16800 aacacctagt tggtgcatta ctaacttgtt agaaatgcac attctcaggc gccattcaga 16860 cttcataaat cagaaactct ggaagtaagg ctcagcattc tgtgtttttt ttttctttat 16920 tatactttaa gttttagggt acatgtgcac aacgtgcagg ttagttacat atgtatacat 16980 gtgccatgtt ggtgtgctgc acccagtaac tcgtcattta acattaggta tatctcctaa 17040 tgctatccct ccccgctccc cccaccccac aacaggcccc ggcgtgtgat gttccccttc 17100 ctgtgtccat gtgttctcat tgttcagttc ctacctatga gtgagaacac gcggtgtttg 17160 gttttttgtc cttgcgatag tttgctgaga atgatggttt ccggcttcat ccatgtccct 17220 acaaaggaca tgaactcatc cttttttatg gctgaatagt attccatggt gtatatgtgc 17280 cacattttct taatccagtc tatcattatt ggacatttgg gttggttcca agtctttgct 17340 attgtgaata gtgccacaat aaacatacgt gtgcatgtgt ctttatagca gcatgattta 17400 taatcctttg ggtatatacc cagtaatggg atggctgggt caaatggtat ttctagttct 17460 agatccctga ggaatcgcca cactgacttc cacaatggtt gaactagttt acagtcccac 17520 taacagtgta aaagtgttcc tgtttctcca catcctctcc agcacctgtt gtttcctgac 17580 tttttaatga tcgccattct aactggtgtg agatggtatc tcattgtggt tttgatttgc 17640 atttctctga tggccagtga tgatgagcat tttttcatgt gtcttttggc agcataaatg 17700 tcgtcttttg agaagtgtct gttcatatcg tttgcccact ttttgatggg gttgtttttt 17760 tcttgtaaat ttgtttgagt tcattgtaga ttctggatac tagccctttg tcagatgagt 17820 agattgcaaa aattttctcc cattctgtag gttgcctgtt cactctgatg gtagtttctt 17880 ttgctgtgca gaagctcttt agtttaatta gatcctattt gtcaattttg gcttctgttg 17940 ccatggcttt tggtgtttta aacatgaagt ccttgcccat gcctatgtcc tgaatggtat 18000 tgcctaggtt ttattctacg gtttttatgg ttttaggtct aacatttaag tctttaatcc 18060 atcttgaatt aattttagca taaggtgtaa ggaagggatc cagtttcagc tttctgcata 18120 tggctagcca gttttcccag caccatttat taaataggga atcctttccc catttcttgt 18180 ttttgtcagg tttgtcaaag atcagatggt tgtagataag cggcattatt tctgagggct 18240 ctgttctgtt ccattggtct atatctctgt tttggtacca gtaccatgct gttttggtta 18300 ctgcatcctt gtagtatagt ttgaagtcag gtagtgtgat gcctccagct ttgttctttt 18360 ggcttaggat tgacttggca agcattctgt gttttgagaa ttcttccagg ggactgtgat 18420 gaaaactgac gtttgagaac cttcatctta gagtaaaaac tttacataca catttttgtt 18480 gttttattta tctagcacaa tacttctttt ttttgaaatg gagttttgct cttgttgccc 18540 aggctggagt gcaatggtgt aatctcagct caccacaacc tccatctccc aggttcagtt 18600 gattctcctg cctcagcctc ccgagtagct ggggttacag gcacgtggca acatgcctag 18660 ctaattttgt atttttagta gagacggggt ttctccatgt tggtcaggct ggtctcgaac 18720 tcccgacctc aggtgatccg cccacctcag cctcccaaag tgctgggatt acaggcgtga 18780 gccactgcac ctggcacaat accttatata taatcagggc tcaaagattt gttgagaggc 18840 tcaacaccaa ttctggacca ggaaagattt tatttatatc actagtcagg aataatctaa 18900 aaacaaaaag cacattcttc ttacaagtaa tatttcaata cacattaatg taaacacatg 18960 gaaaagtatt agctacttaa taaattaaca tgtaaatgaa aaatttacac attatggcta 19020 tttcagatgt gatatagatt tcattttcag aaggaaccct ccaatgtaaa acagtgattc 19080 ttttccccgt ttattttact gcattagaaa atcacattta aagtaagcat tttggtgagg 19140 tttggaaggt gaataaatcc atcttttctt taattatgga tatttaagag agatgttgtt 19200 gtgccgttta gataataatg atctaaacca agaaatttag ttgctttcaa aaataaaata 19260 agtgtatgca ttctgaacat ttttctttag aaacaaacca tttcatctgt ttttttgaat 19320 ttcaaattaa ttatacagaa ttttcaaaat ttgaaaatta ggttagcatg agaaactgaa 19380 gatactgaat tatattgcct gttcagtcta tacttttctt taggatatac agtaggaaag 19440 aaatatgata gttcaagtta gattactact tctttcagag ttttttgaca aatgcaggta 19500 cagtgatagt gtcagttcat ggtgaatttt tgttaaaata aattacaaaa aatttgtgat 19560 cctggtatct tgaaactagt taatatttgt aaactttgct aacactgtat atcactgtat 19620 tctggtttta tctgtgcatc tatgagttat atgtgtgtat agctacatat gtttatattt 19680 atacacatac attacacaca ggagtggaat catactcaat tttttttgta tagcctgctc 19740 tgttcatata atactatatt gtagcatcta gtataagcaa agattaattt ttgtagactt 19800 tgcttttatc ctgaaatttt gtggtagctg gtttaatgga aagacaattt ctgtgacgtg 19860 ttttgtcagt tagggattga ccctggtaaa atattgctgg ataacaacaa gcaatgtaaa 19920 aatacatttg ttccataaga taacctccgt gaaggtagag acttggtctg ttttgtttat 19980 tgcaccgtgt cctgttctgg gaagagtgtt agactcatag aagatgatca agaaatattt 20040 tttgaataca tcaataacat tctctaacat gtgggtatcc taaaggttta tttttaaagt 20100 ttattgatta gaattcagaa gatattttcc cagataaaat aatagattgc tagctgtctt 20160 gaaaatgtaa tttatattta atttgaaatg tcaggttttt gctatttttt ccattaagta 20220 gagatagggt ttttaaaaat tacatgtgat gttttaagta ttctggtttt gcaacaatta 20280 ctagatagaa aatgtaacaa cagatcctat taataatact tccaataata catataaaat 20340 acttgtctaa aagtaaccct ccttaaaaaa acaaagctgg ccaggcgcgg tggctcacgc 20400 ctgtaatccc agcactttgg gaggctgagg caggcggatc aagaggtcag gagttcaaga 20460 ccagcctggc caacatagtg aaaccccatc tctagtaaaa atacaaaaaa ttagccgggt 20520 gtggtggcag gcgcctgtaa ccccagctac tcaggaaaat cgcttgaacc tgggaggcgg 20580 aggttgcagt gagcggagat cgcaccactg tacttcagcc ttgggcaaca gtgcgagact 20640 ctgtctcaaa aaaaaaaaaa aaaaaaggca ataggattag gtatcaactt aatgaaaact 20700 tcgtgacagc actttcttga aaaagactgt ggaaaccaaa gttagtaaac tcctgtttct 20760 gcctgggttc ggaaaacata aagatgataa agatgtttaa gtattccttt tttttttttt 20820 tttttttttt gagacagtgt cttgctctgt ctggagtgca gtggcacaat cacagctcac 20880 tgcagccttg aactcctggg ctcaaataat cctcctgcct cagcctcctg agtatctgga 20940 actacaggag tgcaccatta cactcggcta gtaatttgat tggttaagaa cattaactat 21000 aactcacaca ttttcctgac cacatttgct taggacaaaa cagtaaaaga catgagtgta 21060 gatgaaagcg ataagggaac taatcttaaa cactgaacct cttttcagca aattggcttt 21120 ctagtttctc agctctctct ttacacctct aaatctcttt cctggcaaga tcatttattt 21180 gccttggttt atggtgatac tcttcattgt tatactggtg ggtgattgtt ttaattgata 21240 gctgtttttt tctacttcag gaagatgaca ctgctggctc tgctggctct gatgtttacc 21300 ttgtggctaa tgcctgtgtt tgcctgtgtt cacatttatt ccacgattca tttgttaaca 21360 tttactaagc tgcttttctg tgccaggaac ttggctagat aaataaatgg ttgtttttgt 21420 acacagaatt agctgtcata atcagttact gtagcattta ttcttgcaaa aatatatatt 21480 tatacttcaa ctagtgatcg aatctcaact tattaattca tacattcagc cagcacataa 21540 ttgaatactt cttatgtgtc agaaactgtt ctaggtgctt gggatgttca ttgaacaaaa 21600 tagacaaaag tctccgcctc tatggaactt actttccagt gaaggtgtgg attggtggga 21660 tagaaaataa aataatcaag taagatatgt acttaggctt tcataaaaat acagcagggc 21720 aagaggacca agatggaggc agtgatcagg gaatctcaat gagggtgaga ctgcgacaaa 21780 gacttgaaaa aggtggagaa gcaagccttg tgggtattta gggtagcagt agtccaggca 21840 aggggaacaa ctagtgcaaa ggctctagga ggcaatgtgt ttgaagtgtt ttaagaacag 21900 taaggaggct agtatggtta gaacagaatg agcaaagggg gcaaagtggt agaaggtgag 21960 atcaaagagg taatgaggcc attgtggagg cccatatgga ctattggaag ggctttggct 22020 tttactctaa atgaggcaaa aaccatttta agcagagagg agtgatatga cttgatttct 22080 tgttaaaagg attattctag ttgctgttac agaaaaagat tacaggggtg caaagaaaca 22140 gggagacaaa agaatataag attttcactg taacttatat ctagtatgct tgcttatact 22200 tgaaaatgca tatccagata attgtagtaa attcaaatat tatgtttatt taatagtact 22260 aacattgata tgctggttaa ttatgattag gagcactaat aaagcacaaa tcagggattc 22320 ccaaaaagaa tgttgaaagg gcagtcagct tttcctgtgc cagaaatcaa agtcatagca 22380 gatttggggc aaatatgtca aagtcaaact tacgcacatc actactgaga agacaaagat 22440 gaatgtgtga cagtttcctg cccccaagaa tctttaagca ttgtgaagga agattaatat 22500 agccaaataa ctagagtgat cagttctacc agagaggacc agttttggaa gccagaggaa 22560 aaaaaaaaaa aacagaaaca aaatgatgtt tgaattaaat ctttaaaagt ttctcttata 22620 aatttaccaa gccacatatt gggaatggta ccccaggcag aaggagtaga gtaagcaagc 22680 cagaaaggaa atactatggt gcttttgagt aactgcagtg tggctgaaga atgtggaaaa 22740 tgatgaggat aaagaggtgg acagggaact aggtaaggga gggcttcctt ttaaataatt 22800 agaccttgtc ctgtgtacat ttaatgggat tttaatcagg ccataatgcc aaatttcttt 22860 acttcggaag gatctttatg gtgatggttt cagaaagaaa ttaaagcaga gtaacagtgg 22920 ttagcaataa tgatcagcta gtggttccca aacttacgta tcatatgcat cttggaagtt 22980 tttaaaaact cagattttgg gatcctgact tagatctact gaatcagaat ttacagattc 23040 aaattcccag tgaggcctag gaatttgaaa tgttgaatgt ccttcacgat gcagctagac 23100 aagcatttgg gaataaagca ttaggtgact atttcagtag actaaggagt gggaggccat 23160 ttaagctcaa aggctattct acttctcact atatttctag tacctagcac agtgcatggt 23220 acttgataga tgcatccttt ctcccatacc tcgccctaca catctcttca tgtgtatcct 23280 tattaatatc ctctattata aactggtaaa catgtttccc tgagttctgt gagctgctcc 23340 agcaaagatg ggtttgtgag aatcccaact tttgaagcct gtcagtcaga agttcctgag 23400 gccagacttg caactcctgt tgagggggca gtcttgggga ctgagccctc aacctgacac 23460 tgtctccagg tagatagtgt tagaattgaa ttgaaggaca cccagttggt gtccgctgca 23520 gaactgattg ctcacctggt ggtggagaga acccctcctc tcccgatagg gttgcagaag 23580 ttgtcttctg tgttgttgat tgctgtggtg tgggagcaga ggggggaaaa aagctgttgg 23640 agagtttttt ccaaaacaat aggagattat ttagatttat aaaaatagaa tcaaagtaga 23700 ttaactgagc acattgtgaa atatagagta gagctgtgtg taaggagtat atcttaatgt 23760 caagctgaca ccaaattgaa tgtttgctgg aacgttcaaa aatctaagct tcccaaatct 23820 gtgaaaacac tcaggttagt aaacagtctt atgcaaacag caagacaatg ctcaaagcca 23880 tttaaggaaa aagaacagta actgaattct cttatggaaa tgtgagatgt tgttttagta 23940 agtactgatg gtgttatact ttttgtttat tcgtttgctg gtatttcagt tcctaaaatt 24000 ccttcaaata tgctgcaaaa tacaaaccaa gaacttggtg gattttccat ttgttttcct 24060 gtgggaaatg atggaattaa aaaccttgag gattagacct tgagagttac cttccagtgt 24120 ttatgccacc attatacaaa attctggagg acaaaaccct tcccacttaa aaaccagtta 24180 gtttcagaaa atcacctcat gttaggagac tgcatcatta tagtatgtgt gttagcttta 24240 ggtatagatc taaaatattt ttaatatttt aaaaacttaa gcctttcttc attaatttgg 24300 cctaatacaa gttagaataa ctttaaaaat gagtacaaac aacaaggaag ggccaggcgc 24360 agtggctcaa cgcctgtaat ccgaacactt tgggaggcca aggtgggcag atcacctgag 24420 gtcaggagtt ccagaccagc ctggccaaca taatgaaacc ccatctctac taagaataca 24480 aaaattagct gggcgtggtg gcacacgcct gtaatcccag ctactcggga ggctgaggca 24540 ggagaattgc ttgaacccag gaggcagagg ttgcagtgag ccgagatcgc gccattgcac 24600 tccagtctgg gcaacaaggg tgaaatgccg tctcaggaaa aaaaaaaaca gtttctgtga 24660 ctgctagaca aatgttgagc aagtaaaaca ccaacaatgt tgaacttaga tattgaaata 24720 gctgctctgt acaaataaag tctactggga gtatagactg aattaccatc ttttgactct 24780 ttcgccataa tgattggcat taccggaagg gattaccttg ctttgaagag ctgctggaca 24840 gtagagcaga gagcatctat taccattgta ggtgcctttc agttaggatt ttggatttat 24900 aagcaaactc caagaaagag cctggttctg agtttctctg aatagcttag gtcaagtcct 24960 aaattctgaa gccaactcct ataattcctt ctttatgtct ttggcatgtg aagtaggcaa 25020 atttcgaact ttataataat agcctagact tacaaatact tgccttggta atcaggatga 25080 gtttttgaga gacaacatag tctagtgtta atcgcgtgga caccagactg cttgagtgaa 25140 atacaggttc taccatttat taacggagta atgttgggta agctatttag ccagggtcct 25200 tatctgtaac atggtgataa taataaagat taaataatag gtgaaaaatg tttagaatac 25260 cactgtgtta ttagtaagca ccatgcatag gtgtttggat ttaaaaatac tggcaaaggc 25320 caggttgggt ggctcacacc tataatcctc gcactttggg aggccaaggc agaaggatcg 25380 ctttagccca ggagttcagg accagtcgag gcaacataga ttccgtctct gcaaaaaatt 25440 taacagaatt agttgggcat ggtagcgtgt gcctgtagct acttgggagg ctgaggtagg 25500 gagggggagg attgcttgag cccacgattt cgaggctgca gtgagcttat gatcatgcca 25560 ctgtactcca gcttgggtga cagagcaaga ctctgtctct aaaataaaat gaaaataaaa 25620 ctgcaggcaa aaatgccaac tgaagagtga acatgaactt ttctttgcat ttttcttggg 25680 cctgagactt taagaagtgc agggcagtta aaatgatgag atataattct cacctatcag 25740 ctcagcagaa attaataaga ttaaaaagat gcgtaatata taatattgca gagtgcatgg 25800 gggaattgat atacacattc atgaactggc agagacaaaa atgggcacag aaccatttgg 25860 aaagctattg tgtattttaa aaaatttcag tagcacattt tttatatcat gaaatttcac 25920 ttcagaatgt cagtcctgta gaaatactga cgcaagtgca aaaacaacaa aaaccaactt 25980 gtaccttcaa ggccagaaag agttatttca ccaaataaca taattgaggt acattaactt 26040 tattagaagt aaatctgata atctgctcac attttaaata gttatggttt aacttcagtt 26100 cttgaagtca catattttta caattaggaa tgctaacagg ctttttgtgc aatacgaaaa 26160 gatgacttta aatgcctaca attattttgt gtccttttat ttttttttaa tttttactga 26220 cctactacaa agcactaaat attttatgtt cttaatctga agaacaatag acattctcta 26280 taaaacaact cttgcttatt catgaacttt gtacacaaga agcttaataa gacgggctca 26340 aaattatttt tctaaatata tttcctatac aaaataattt caagatataa ttgttacttt 26400 tgtgtctaat actgtatgtt aaataataaa atggtaagca tgtaaaaact acaataccac 26460 aaagattgag ctattttgcc agtagtatac tccaacttta gttctagaac agttgtagaa 26520 atgggtaaac aaactgtttt aactgtactc ttaactgaaa tatagtacct tatgcagtag 26580 cagaacatat cagcagaaga acttcacttg acctgtactt aaaaacaaaa cagatgcaat 26640 ttataaaatt tagagaaata tagtgacctt atttgcatgt ggaaaatgta cttctttctg 26700 atctacatat cttctgttgt gcaatgtaag cagtaaaaca aatagtacag gattcatctc 26760 tgtgggacct agaccccctg gtctaacaaa taattcttgg tcagtactgt aattctgtgg 26820 tataaaactg ataaaattag ccttcctgtg actagacaag aagccgggca gtttaaatgc 26880 tgaaactcac aagaacttca gaagctttag ctttaagctt taagcttact tagaaatgtt 26940 ataagacctc cagtagtcac atatgaagaa tatcatgaag atttttccat taaatcttta 27000 ttatagatcc cttgattggt ttctgtctag actcattgtg tgataaagga cataataatt 27060 tttatcacct tcatctaata taggtttgtc aactctatat tagttgtttt cttgaaggct 27120 ggttttcttc caaaattcag tcttattttc agtctacact agcttttaaa tatactgtcc 27180 tttagatgct ttatctaacc tcaaatttct aatggatttg tcttagacac ttattgccac 27240 tccttagata gtcattgcta tctttgaagt tctggacgat acgtgtatta cagaggaact 27300 ggagacattc catcaccata gttagcttga ttggataccc tttaaaagca tatactcgcg 27360 cctgtaatcc cagcactttg ggaggccgag gcgggtggat cacttgaggt ctggagtttg 27420 agacaagcct ggccaacatg gtgaaacctg tctgtactaa aaatacaaaa attagcctgg 27480 catggtacca catgcctgta atcccagcta ctcaggaggc tgaggcagga gaattgcttg 27540 aacctgggaa gtggaggttg cagtgaacca agatcttgcc attgcactcc agcctgggtg 27600 acaagagcag aactccatta aaaaaaaaaa aaagcatata tagcacatat tataaggttt 27660 tcaatttttt caccaagtgt ttcatttggg tagtcattta ttggtagttt acatcagttg 27720 agtggttcag aaaaaataca gtaagttgct tataaaattc tgaacacttt ggccaggcac 27780 aatggctcaa gcctgtaatt tgagcccttt gtgaggctga ggcaggagaa ttgcttgagc 27840 ttaggcgttc aagaccagcc taggtaacaa agaacgcctg gaatgattgt ggcatttgaa 27900 ctaatattca ggtttaacaa gagataattg accatcactc tattttagag gctttatttg 27960 aaccagatag aaatctattt cccacagcta tcactgcctg tcacctacaa cttaaggggg 28020 ttggggagga agtgagagat tttctgttag ggccaatagg gacctgctag ataccccccc 28080 atcctgggaa tggtgtatgg aactccagtg tatgctggag ttattatcat catacttgtt 28140 tttttatttt actcttctgc ttatacagat caagtcttac gttttatttt taagtttaaa 28200 ttgaaaacat ttacagagaa caatgcagtg aaatgaaaaa attacagact gctggcattt 28260 gcattttcat gtagcctcag tgactaattt ttttttattg tacagcattg agaaaatcct 28320 agttcatata actagttata gttcatatag attcatataa ctagttttaa gtgataatag 28380 tttcttcctt tttttcctcc accatctaac cagatgaaga taatagtttt taatagctca 28440 ccgtaaattt caaggtactc aagttaaatt gatctagatg cttgagttga aatttttcta 28500 tcaaagttca ataacatgct tacattcctt attaaagtat aaaagtccta taaacacaca 28560 aacttgagta agtactaaaa ctagtatcag tattgtcaca atacaacatg ttatattgta 28620 acaagagcat ttgctgagaa ctgtgcttgt tactccagaa tgttgcttct atggttgtac 28680 ctttcaactt tgcagatcat ttggaaggag gagagatttg gggtggagac aattcggtac 28740 ttcattcaca ggatgtaagg aggattaagt aaaataatgc tggctaaaag tccttattta 28800 gcatactgcc caatgctcac taaatcataa tagctgtttt taacatttgg tgaagaatct 28860 atttaacagg agtgagttga ggggcatagg agatcatgtg agtgtttaaa gtagaagcag 28920 cattccccat taagaagaga aatactgtgg aagagcaaag actttaaaac acctgggttc 28980 aaatcctatt tgctacataa tggctacttt taacctattg aacgccagtt ccctcatttg 29040 taaaataggg acaatattta acctatttac aggttgtgag agaactaggc acctagtaca 29100 gggtaatgtt ggcacatggt aacctttaat aaactgttgc tattcaacaa gctattagat 29160 gtcactaggc agttaagcaa aggaagacag cttttgcttg gtgtgacaat gaaaatcttt 29220 ctgatttcct tcttggaaga gttccctgaa gatatgtcat tgtattgaca cctttatttt 29280 tgctaaccta tccctctaaa ttctggatat tgtgtgtgcc acagcttttt ttcttccata 29340 ttcctgcatt tatttggcac ctgttgtgcc agtaatagat aaggggctgc taagggagga 29400 ggcaacctgc actggcttat agctgctaat gtcagttcct atagcttatc gtcagtgtta 29460 ttcatgtggt aaaagggtga gaaagtactg gagtctaaag aaacaagtag aaatcagttt 29520 gtagctatta ccgttctacc tgctaacaac tcctgttttc aagttattat gtacaacttt 29580 aggtagtttc tctagcctta atcgtggttt ctctgtattg agactacttt tgaattctat 29640 gaagtacagc cttagatgta caggctactt taaatttttg cctaaaataa aaacattctc 29700 tccaattaca tatgctgggg aggaaacacc tgcttccgac aggtttaaag cttggttttg 29760 gactttttgt gagagttcct tatgtgtgca gtaatccaaa atttgtatag ttgcccttta 29820 taaaagtaca ttaatctagt agacaaatct ccatgtaact taattacatg gcatcttcta 29880 atccttctgt gataagcaga aatgtaaagt tttattcaag ttaaggcaaa ctaacttgta 29940 tacactttcc atctcgtgtt tttcttgttg ttgttaagta ggataagttc tgaacgtcga 30000 aaagaaaagt ctcgagatgc agccagatct cggcgaagta aagaatctga agttttttat 30060 gagcttgctc atcagttgcc acttccacat aatgtgagtt cgcatcttga taaggcctct 30120 gtgatgaggc ttaccatcag ctatttgcgt gtgaggaaac ttctggatgc tggtgagtta 30180 ttttacaagg gtataaatag gcctgaaaat tagaagttag aagtaaatag aaattatttt 30240 tagaaggtgg tcgcaatgtt ttgattttgt atacctcttt atattgtgat atgtacacgt 30300 ttaaaaattt ttctgtaatt ctcactattt ttatcaagct tcattttttt ctcatcagtt 30360 attctttgaa ataatcattc tttatgcaca taatttgttt tgctttattc tcttaaacat 30420 actctcaatt cttttctaat ataacatcct ttttattacc tgcttttaaa gctttagtca 30480 ggaataagat actggctttt cccctccccc ctttttctcc tgttccatct acctttcttc 30540 ctttaaaaaa catgactcag gccgggcgcg gtggctcacg cctgtaatcc cagaactttg 30600 ggatgctgag gcgggtggat catgaggtca ggagttcaag accagcctgg ccaagatggt 30660 gaaaccccat atataccaaa aatataaaaa attagatggg cacgctggta ggtgcctgta 30720 atctcagcta ctagggaggc tgaggcagga gaattgctta aactcagagg gcggagcttg 30780 cagtaagccg agatcaagcc actgcactcc agcctgggcg gcagagtgag actccatctc 30840 aaaaataata aaataaataa ataaataaaa aacattactc ttctttcttc ttctatggtt 30900 tgctttgctg cattacttta atcatgaaaa gcagctggca catctaatta tagtttttct 30960 agcttctggc ctgcactttt ctgtgttgaa atggctgtat atattaaata aagtgtctgc 31020 gagaaaactt tgtaaaaaca tctaaatatt atatcattta agtacaactt tttaactaat 31080 tattttcctc ttcttgtgcc ctttttaggt gatttggata ttgaagatga catgaaagca 31140 cagatgaatt gcttttattt gaaagccttg gatggttttg ttatggttct cacagatgat 31200 ggtgacatga tttacatttc tgataatgtg aacaaataca tgggattaac tcaggtaaaa 31260 tgcacacata ttaagagctc ttctatatgt ttttatgatt ttatgatcta gccctaattt 31320 ttaaaaatgt gtttacagtt tgaactaact ggacacagtg tgtttgattt tactcatcca 31380 tgtgaccatg aggaaatgag agaaatgctt acacacagaa atggtaagaa aagtctgttg 31440 tttgatttaa tgtgacaggt ggttttacat aataagatac tattgctaat tattaaactt 31500 tgctattgta cttacccaag gcaaaatgtt atttcatgtt taataaaatg tctattcttt 31560 gttaaaacta ttattttagt ttttaggaat ttcattttga aagcccacct aattgcataa 31620 ataattgtgt gggtgtgaga aataaaatgg aaaagtaaaa tcatgaccaa gagagttaca 31680 aataactttt tttttttttt tttaagatgg ggtctcgctc ttttgcccat gctggagtgc 31740 agtggcacaa tcagctgact gcagccttga ccgctgggac tcaagcgatc ctcccacctc 31800 agtctcccaa gttagctggg accacagacg cgtgctacca tgcccagcta aatttttaaa 31860 aattatttgt agagacaaag tctcactatg ctgctcaggc tggtcttgaa ctactgggct 31920 taagccatcc tctcacctcg gcctctcaaa gtgttgggat tacaggcatg agccaccacg 31980 cccaggctac cttttttttc cttttctttt taaattgtga taggggttct tgctgtattg 32040 cccaggctgg tcttaaactc ctggactcaa gtgatcctcc tggctcagcc tcccaaagtg 32100 ctaggattat aggcatgcgc caccacacct ggtggagtta aaaattaaaa tacaccatta 32160 aggcaaggag aaattataat acaaatggca gataatagga ctttagacag tcattaaagt 32220 tgaggtgcca gtttgagtct aaggcccaat aaaaaaagtt caccagaatt ttaagacaaa 32280 caactgctta tttgacttct ttggatgttc tcaataattc gagaccgtgt agttagatta 32340 taaagtatta cattgtggat gcccacatat taacaaaaat agagagtaag acctctaatt 32400 cttaggaatt aattgttaaa aataatcaag tgttccaaga ttttttggaa actacctctt 32460 gaattaaaaa attaaagtct ttctacattt ttatcttgtt aaacagtgta tactgatcat 32520 aattatttaa aaaatcatgt gttctaagat ttttggaaag tacctcttga attacaaaaa 32580 caagaaagtc tttccacatt tgtgccttct taagcagtgt atactgatca taattgaact 32640 tttcttcatg atggaaagtt accacaagga aaatttctta tgttctgctg ttctttgttg 32700 ctctccaatt taagtgcata cgtttgtttg cttctatatt ataaaacctc aaatttactt 32760 tttgtataat ttttgaggtt ttctttttca tctcatttat tataataata gctaacctcc 32820 attgagagaa tgctgtgtgc caggacactg ttcttcctat tttatatgct tttaactcct 32880 ttattcctca caacaaccct gtgaagttaa ctgttagaca atttctattt tactaggaaa 32940 ctgaggtaca gagttactaa gtaactttcc caacattatt tggttagtaa atggcagagc 33000 ttgggctgaa cttcagtaga ctggcttcag agtccacgct cattagtcct ttggagcgct 33060 tttcatattc ttgaattctc acattctgtc ttttttcact ctgtcagcag gacctgactc 33120 ctgtttttaa atttcatatt gtgtttttac tgttaatttg gaaaacaaat gcatactttt 33180 tagaattctg tataaaggag gagtaaatat gctgtgaaca aggacctaag tgggttgtca 33240 atgagtttaa tatatgagtt ctaatgtgca gagttgaggt ttatattgac tgctcagtgc 33300 ttccctgggg ctagactata aatggatgga tattaggaag tcttgttctg atttggtaat 33360 gatgttaatg cattattcta aatcagatag tcttaatata gtttaaatgt atgtttcgaa 33420 ccaaatgttc ttttttaaag cacacaaaca ttttgaaatc attactaatg tggttaatga 33480 attattgatg ttccattggg aaactaaaat gcagattttt ctcttttaga aatcagggac 33540 tattgcaaag catcacattt tagtgataca ctgagagcca gtggtgtgtt tatacaaata 33600 gtcctatttt ccaaataaat tctagaaaaa tgctttagaa tttataaatt atacaaaata 33660 tgacttattt ttagagagtt taaaatttag gtttttttaa tggtttgttt ttgtttgttt 33720 gttttttgtt ttttttttcc tcattaggaa aacactagta cttttcagtt accttgattt 33780 ttaaattaat ctgcaggtcc ccattcaaag gccttgggtt cctttcaaag gtcagtataa 33840 ttcaagctta gtttatgaag gactgaacat acccaaagga ttttgcatgt ggatctttac 33900 tgccactacc acaaccatca acacctacac acacacgaca cacacacatt ctctctctct 33960 ctctctctct ctctctctct ccccctccct cccgcactcc ttcccttccc cctcctttgc 34020 tctcatggca tcttttaaaa atatactctt aaatccttcc agggagggca aattcacttc 34080 ttaatctaag taaacccaaa tggcatgcat cagcaccagg actgcccatc tttcctagtt 34140 ccattattca tagagtatag gctggaattc atcttgttcc tcaagagtcc agcatttcta 34200 gttaaccatg cctacattta aacttactct catttctttt ctactttaca gtgttttttc 34260 aatatactag cattacagtt tccagatttg atttctctcc tgtcttattt ccatcagttt 34320 tcaagtctat taagattcta cctcttcatt tgtcttttgc caccattctt ttccctcata 34380 ctctactggc tcagccctct cattacagtc acctaattct aacatatata ttgctgctaa 34440 gttaattttc cttaagttac tgattgtgct tttttaaagc cccttgttga atatttaggc 34500 aggactccat gtggacatcc acagccctcc gtggtacagc cctaaccttc ccttctagct 34560 ttgccttact actcttctac gtgtactcta cattgtggac aaactactat atgctgtttt 34620 tcaaacatgt cctatttttc ctacctctgt gcttttcatt ctcttacttc tccttggaat 34680 acccttctaa cccatctcta cttactgaca ttctaatgtc tctttttcta agcaagactt 34740 cttgatttcc cttgactaga aattatcttc taagctctcc ctatccttct ttaaagcatt 34800 tttataagtc tcaagtacca actctacatt gtgtttttgt tgaccttact atatctacta 34860 catttttaac ttcttcagga aaggtggcgt atcttactca tctttgtatt gcctacaata 34920 tctagtccag gttctgaata ataaatattt ttatatgtgt tctgaagcac actgaccaat 34980 gaagataaga aatcaagagg ctagttcctt atttttttta attttttttt ttgagacagt 35040 gtctcacttt gtcacccagg ctggagtgca gtggcacaat ctcagttcac tacaacctct 35100 gcctcccggg ttcaagtgat tctcacgcct caacctccca agtagctggg attataggca 35160 tgtgccacca cacctagctg atatttatat ttttagtaga gatggggttt tgccatgatg 35220 gccagcatgg tctcaaactt ctgtcctcaa gtgatcttcc tgcctcagcc tcccaaagtg 35280 ctgggattac aggcatgagg cataagccac tgcgcccagc aagatgctct tttctcagtc 35340 acctaaatat aatctcattt ttagttatag aaggtttgaa attggagtga atagacttta 35400 cttaattctg actttatttc tgtagctttt tttttttgag atggattctc gctctatatc 35460 ccaggttgga gtgcagtggc acagtctcag ctcactgcaa cctctgcctc ccacgttcga 35520 gtgattcccc tgcctcagtc tcccaagtag ctgggattac aggcacccac tatcacaccc 35580 agctaatttt tgtattttta gtagagacag ggtttcacca tgttggccag gccggtttcg 35640 aactcctgac ctcaagtgat cctcttgcct cagcctccca aagtgctggg attacaggca 35700 tgagccaccg tgccctgcct atttctgtaa cttttgataa gtcatttgat ctgttgttgt 35760 tgttttctca tagtaacaaa gtagaagtaa ttttctgcct gctttactag ataaattaag 35820 gggaaaaaaa taagatacgt aaaaatgtta tttgttatta aaaagaaagt tgttatttta 35880 aaggttctat aaagacatag agtgcttatt agaaattgag ctaacacatt caggaaagga 35940 taggaagagt ttgctgaagt tctttcttta gggattcttg tgtaccgata gcacagttaa 36000 agagcaaact cataccattt ttatatttct gtgtatttga ctaagcttac tggcttcaat 36060 gattaactgt tatcccaaat atggattatc tttcagccaa ctcagggaat cacagctact 36120 gagtagtgtg tgtcagatct cttgggtgtg ctggagtgag taaaagggga atgaattact 36180 gtgttcatgc tgagacttaa ttgaacgggt attcagttga tctaggtgat gggcactttg 36240 ttacttttat tgtaacaaat ttgtatattt agttgcttta aaactttatt tcatgctttc 36300 attaggcctt gtgaaaaagg gtaaagaaca aaacacacag cgaagctttt ttctcagaat 36360 gaagtgtacc ctaactagcc gaggaagaac tatgaacata aagtctgcaa catggaaggt 36420 aagtgaaaat tatttgtgat tgattataca ctttatttat acatagacat tgtagtatta 36480 agataacttt agaattgtga gggaaggttt acagttccat ggtgtttggt tatgtaacat 36540 ttatatcttc aactcatttg catgtgatct ccaaaatgca gaaccgtgta gtaatttgcc 36600 aatttgaggc acaaacttaa attacgtgaa ttgtggcact ggtgttccag gcttaatcag 36660 ttggctttgc cagccacaca atatttgaat cctgataggg cttaattttc tattaatcat 36720 ggttttatat ctttgttcaa tgttgaaaca tagtcatcag tgcaagaaat aactatcaaa 36780 cagccatgat gatgagatga atgaaaaagc agcctagact ttatacgagg ggaatttttt 36840 aaagagtaat gtataggccc tgggcaggaa gtaggtcata ggtggtatca taggaaaaat 36900 gttcattgat tttcaaaaac gtgattaatc cactagtgac agtaaatttt atcaaagctt 36960 actggccatg tcagactcaa ctacttatct ctgctttttt tttccctagc attgtaaata 37020 ttttttttaa ctgctttgtt cttcatacac aggtattgca ctgcacaggc cacattcacg 37080 tatatgatac caacagtaac caacctcagt gtgggtataa gaaaccacct atgacctgct 37140 tggtgctgat ttgtgaaccc attcctcacc catcaaatat tgaaattcct ttagatagca 37200 agactttcct cagtcgacac agcctggata tgaaattttc ttattgtgat gaaaggtaaa 37260 ttagatctaa aatgtgaatt tgaaattttt aattagtcta cagcattact gaatattcac 37320 catagcaaag attcagcgct ggccatgcat ggtggctcac acctgtaatc ccagcacttt 37380 ggaaggctga ggcaagcggg gggtggatca tctgaggtca ggagattgag accagcctgg 37440 ccaatgtggt gaaaccccat ctctactaaa aaatacaaaa attagtggga cgtggtggca 37500 ggcactactc aggaggctga ggcaggagaa tcgcttgaac ctgggaggtg gatgttgtgg 37560 tgagctgagc tcacaccacc acactgcaag cctggatgac agagcaagac tcccatttca 37620 aaaaaaaaaa aaaaaattac tcaatgttaa actatacttt ccactaaatt gaacagaatg 37680 atacatccta taatattaga ttaactttgt aaattaattc agccacattt attgaacatt 37740 tactctgtac tatgaacact tactttacta ggtgctatcc agaagttaag atgagtcttt 37800 ttttccccaa taggggctct acttacttag agaatttcaa agatatgcag tgtgtatttt 37860 gagcaaagat agattacctt aggttgggga ctagaaagcc aagtgtttgt acatctcttc 37920 atcctacata ttttccctga gaagcttcaa ccttgcccat ggtttctatt actatttccc 37980 acatttcttc ctgtaactaa ttctatttaa ttgccaactt aatatttcta tctggatatt 38040 cttctgtatt gtaaactaag tattactgta acaactgtac tactactgcc cccaaacaac 38100 atcatcatca aaaactgcct ttcttcctat aatgcttatt gtggtttaat acaccaccat 38160 acacacatga ctccagcaaa actttggaag tcatctgtaa cttttctttt acattcattg 38220 gctacataca gttggtgtct aaatcttaca gatttactat ctacatatat ctcttgatcc 38280 atttcctcct ttccatcctt gcactcctgc cattgaattc attagctcat tattactctt 38340 gacttgagtt gttggcatag ctgccttttt gccaacagat ttgtaccctt ataatctttc 38400 atctaagttg ccagaaagtg ggtgtcctaa tgtgaaaatc agatcatgtc attctgttgt 38460 tgaaaatgcc tcaaatgctt ccctccatct ttgcacacaa aaatattttg tttataaaaa 38520 tactagatga gggaagtaaa tttttcattt atcaaaagaa gatgtgtatt ttagaagact 38580 gaaaaaaaat agacctacac aatacaatct aaacttagca tggcaaacaa agatatttat 38640 gctctggccc taactctgtc tttggaatca gatgttagat tcactcatgg cttgcagctc 38700 tgatacttac aatgtggcct tggccttggt acttaactgt tgtaaaattc acattcctta 38760 tctataaaat aagaatcatg gctgggtggg gtggctcatg cctataatcc tagcactgtg 38820 ggaggccgag gtgggtggat cacctgaggt caggagtttg aaaccagcct ggccaacatg 38880 gtaaaacccc atctctacta aaaatacaaa aattagctgg gtatgggggc acatgtccgt 38940 aatcccagct acttgggagg ctgaggtagg agaattgctt gaatccagga ggcggaggtt 39000 gcagtgaacc aagcttgcac cactgcactc cggcctggga gacggagtga gactccatct 39060 caaaaaacaa aaacaaaaca aaaaaaagac ctcagaagga tgttgtcagg attaaaggag 39120 tccattgagt gcctagtaca gatagtgaat gcttcactac tggtgtcaac tttaagaaaa 39180 tgaatataga aaagctaaga attattttaa ggtgtttact actagcatgt aaatgtatga 39240 tgggacagag atttccatcc tattttgagg aattattttt tatttttttg aaaacttaag 39300 gtaacaaagt agagaggagg ccagggagaa aggaaggtag tggagcaaaa atgagaaagg 39360 gagtgacatt cccctctagt tatagcagaa aattagcaaa atgatcatga caggaggtaa 39420 cagtaaagac agccagctca tatatcaacc aagacagttt tgagtttgac cagcagactg 39480 ttattttctg gtttagagct ctttccagga acttcttgca tctataaccc ctgagaacca 39540 agctatggaa aaaattttgc tcaattttaa gaaaatctaa catatcaagc tcctcaactc 39600 caaaatattc cacaaatagc tgctatttac tatactgagt aataatcatt taaaattatt 39660 caacacttta tttgagcatc tactatgttc atggcactaa agtagaaatg aagatgaaca 39720 gttcctgcct caaaataaat gagtagtata ctgctttaga tcatgggttt cctagtccat 39780 taaaaacact ttttggtcat attttctgga caccccgacc cttttggtat agaatataac 39840 ctatgtaatt ctctaaagtt aaattaacct cacttttctt gctctaatat gtgtaaaact 39900 gaccttctag gaaagcatat acagtttata tttttgactt cttggtatct tttagtgata 39960 gacatacctc agattgagaa gcactgattg acattagatt aaatcagagc ttcctatgac 40020 aatataaaca ataccttcat taatctgatc cccctaccta cttcttcagc atcatctcat 40080 atctgtctcc actaatcata ttatagaatc tttgttacct gcaccatgtt aagcattttt 40140 aaaaatcttt tgtttatacc ataccttttt cctgaaagcg gttttgcctt tcctttgtct 40200 ctagtcataa gtctcctata agaggctgtt cctcattcta ccattccttt gcatggatag 40260 gattccatgg aatagattct catcactgca tttatcacat tatttcctaa gtagtacagt 40320 acatctactg gaagattagc cacgtattga gttttgtctt tgcattttca tgcctagaat 40380 aatgccgggc acacataggc atattaagat ttgaatagtg aaaaagtttt taattccatg 40440 gggattttat ttaaacagaa aaatataaga ccaattagaa ttatttttaa agcataattt 40500 caagaaatat gactgatttt gtttaaaaac atgttttcct ttataatgct gccacctggt 40560 gttgctgtgt ttagagatgt ccctttgtaa agaattgagg gtttgagttg agtttggttt 40620 ggtttttggc aaatcagctt ttcctttgta tatttatttt gtaataaact atggaagatc 40680 ttgcctttaa gtgtgagaac acaagcaatg ttacttttat acctttatag aatatcttgc 40740 ctatgtcctt cctgtagtta ggtagggttt tttttttgac acacagcatg ttatataagg 40800 tttgcttgca cctcggtagg aaagtcctct gaaatctaaa ggctgagaat ctaaaagctt 40860 aactcatgtt ttgctcctag aaagacttga gaagagagta tttctgttca gcatggtact 40920 aagaagacag ctttctcttc ctcatgtcat ggttgccatt tcatactgct tacagagaat 40980 aagatctagt ctctgtctta aataaaggtc tactctctgc cagcgagcta gatagggtaa 41040 ttggattgtt ttccaatcta ttttcatttg aaatattgtt ttatctgaaa ttactcccat 41100 aatttcatgt aatgccaaaa actaaactaa gtacaagagc atcttcaaaa accaacataa 41160 ttcctttagt tcccatttag tgtagatgct ctttggttga tgatattaga attgtgtaat 41220 ggctattgat ctctcaaagt gaggtgttgc ctaggggctt aaaagttact acataaagaa 41280 tttggcttta tgaagaaatg ttacagattt tatctatatt ttaaaataag tgtaagtgac 41340 tacctttata acttttacca tgtagtttag tagtatttct tatctgttta ttaataccct 41400 gccttgttac caaaagtatg tataatgaga tgtaataaga ataggtaaca agtaggctgg 41460 gcacgttggc tcatgcctgt aatcccagta ctttgggagg ccaaggcggg tgaattacct 41520 gagttcagga gttcaagacg agcctgacca acatggagaa accccatccc tactaaaaat 41580 acaaaattag ctgggcatgg tggcacatgc ctgtaatccc agctacttgg gaggctgagg 41640 caggggaatc gcttgaacct aggaggtgga ggttgcggtg agccaagatc acacctcatt 41700 gtgctctcca gcctgagcaa cacgagggaa actcttgtct caaaaaaaaa gaccaggtaa 41760 caagtttggg tgaacaggat taaagagtta aataacagga ggaatctaga ggacttaaag 41820 aaatgtgtgg tgttggattt aataactgta gttgccaaag gtgaggtgta aatttattct 41880 aagcaaagga ggatgctcat ttttgaaaat tcacttgtcc ataagattaa tgcctatcag 41940 ttaacttggg aggagaaaaa tttttcttta tcagtgtctc cctttttttt cttaaatctt 42000 gtatttttta ctaacagaat taccgaattg atgggatatg agccagaaga acttttaggc 42060 cgctcaattt atgaatatta tcatgctttg gactctgatc atctgaccaa aactcatcat 42120 gatagtaagt acaatggaag aactcagaga tattctaatt acttaactgt tgcaacctct 42180 gtacagtttg gctacccatc taattctctg gttaaaagtt ctagactaaa tgtgttaaca 42240 ggcctattca gtagagatct tgaccatttt gtgttttgta tgtgttgcaa caaatatcag 42300 taaaaataga atcatttaat catagaaaaa acttcctggc attttaaata caaagacttt 42360 tgaaaatcca aatattatag agtattgaat agcataattt tcagaattca cataaatact 42420 cagaacagtg gttggtatgt aaaaggcact cagaaagtat ttgtacaatc aatgaatgtg 42480 aaggtggtga acatcacctt tggtaataag taccatttta aaaaatgctt ataagtgcat 42540 agttaggtat ttatatttat gggttcatga aatattttga tataggcatg cagtgcataa 42600 ggataaatgg agtacctatc acctcaagca ttatcttgtg tgacaaacaa tccagttata 42660 ctcttttggt tatttttatt ttattttatt ttattttttt cttttgagac aggatctcac 42720 tctcgcccag gctggagtgc agtggagcaa tctcagctca ctgcaacccc cgcctaccgg 42780 gttcaagaga ttctcctgcc tcatcctccc aagtagctgg gattataagc atgtaccacc 42840 atgcctggct aatttttgta tttttagtat agacagggtt ttgccatgtt ggccaggctg 42900 gtctcgaact cctgacctca ggttatccac ctgccttggc acccggcctc ttttagtttc 42960 tttaaaatgt acaattaaat tattttttac tatagtcacc caaaacaagt acctttgaca 43020 taagatttga ttctgaattt tactcaaatg aatgttaaga tccccaagat aagttaaact 43080 ttggactatc tcacctgttt aatctgtacc tatgcatgac ttcccactgt gcttgaggat 43140 acctgaatat cactgagttt gtgtgactga tcagccttga actcaagagt aaatccaagt 43200 ctgcagtcag gacaccccaa tcctcaaaat aataccatca ttagcattta tttagtactt 43260 tctcccaaat cagtatttaa tttaaattgc caaaagactt acaatgtggt atcaatttat 43320 atttaaatat gctacatata gctttttaaa gcatctttgg ttctctggaa accatagtca 43380 gaatttaagg aagttattgt ggcaccattt tcttgaaaaa ggctattgat tattctctaa 43440 tctgacacca acctaagtca ttaaaggaat tttagttact gaagattgta tattcatgaa 43500 ctcttcactt agctcactgg cagcaaagga gttttattta gggggtttga aaaaggaaat 43560 gggtacattt tcagctattc tgggacgcac tgtcagaatg taagcagtta caactgattc 43620 cactaaataa acatttgttt tccaaaacaa tgatgaacat tcagcatctg ttcatttaat 43680 tgaaaattca aagttaaaat attttctctg catgattctt tttcttttcc cccctagtgt 43740 ttactaaagg acaagtcacc acaggacagt acaggatgct tgccaaaaga ggtggatatg 43800 tctgggttga aactcaagca actgtcatat ataacaccaa gaattctcaa ccacagtgca 43860 ttgtatgtgt gaattacgtt gtgaggtaag taagtttgag aaataaacat ttttggggaa 43920 caaatagtaa ttctttttgg atactctgtt catttatagg aagataagat aataaatatt 43980 aactaaattt taattctttt acatcgctac caaattatta ttttctatac tctgacctag 44040 gtttccagtc cagctattcc acagtgatgc tgctaaacac tgtcagtagt tgtctatccc 44100 cataccttca ctcctatttt taaaaagacc atgaaaaaaa taccagatcc attgattggt 44160 ttggtctaat tatacagata tcggcatata ctatctcaag acagctgtgt tctttttgta 44220 ggaagaatcc tggcctagat ttgtatcata gctctaccac tcattagctc cctgaccttg 44280 gggaagtctc ttcatttttc tgaatttcat ctatgtagat aatccttcag aaggttataa 44340 tgaaaattaa atgaaattct atgagattag ggagggggga gggatagcat taggagatat 44400 acttaatgtg aatgatgagt taatggatgt agcacaccaa catggcacat gtatacatat 44460 gtaacaaacc tgcacgttgt gcacatgcac cctagaactt aaagtataat ttaaaaaaga 44520 aaagaaattc tatgagatta ataagctata tgatgtaata catggctctt gtatattcat 44580 gaactcttca cttagctctt tggcttgtga atattatgta catcaaaatt taatttttca 44640 tttgatctat tttactagac tcctgcccca tctagtctac ctgtccacat tattaccaca 44700 ttctagtcca tcttgcccat tactaccagg ctaagctttc tagtgtggat atgtcatcat 44760 cttattttcc ttagaatttt agcgatcttt ttatcatttc caagataaac acttgcctag 44820 gtgtacagca tccttgttta ccatcatact cacgcattag agatttagcc ttccctttaa 44880 aatctagggt cactcctctt aggaagactt tgggcagttt ttatttttgc tacttctgac 44940 accatccttt aatgttttaa tattagtgcc acagagttct tttgtgactt taccattatg 45000 taagaatctt ccacttggaa tgtctttctc ttcctcacac cccagtctgc ctagcaaatg 45060 ccacttgatc ccaagtatca gcttgttagc ttctcagtga agcaagcctt ctctatttta 45120 gcagttatca cagtgtattt taattgttta catatctact ttcacaatgg gttataaatt 45180 tcttaaggtc aagggttggc tattttaatc tttgcattat cagttcattt cagatagtga 45240 acatttaata cgttaattaa aggaataatt tacatttaag ccaaacgtga agataaacta 45300 ttgctcatca tccctcttca gccgtatcct gtaggtggta tcaccttata ttcttaccac 45360 caaagaaaat atggcccctc tcttagaaag atcttaatca tttatctgtg tatctttagg 45420 actatcctta gatcatgcct cacatattga tgccaaagag ttcttttgtg ccaatttcat 45480 aatgtgtgtc agcacaacaa ttctgaagat ttgttggtgt ctttcatgta cttgactaca 45540 aattgccttg ccattactac tcttctcaaa ggatatctga aattcttttt ttcttttttt 45600 tttttgagat ggagtctcac tgtcacccag gctggagtgc agtggcgtga tcttggctca 45660 ctccatttcc cgagctcaag tgattctcat gcctcagcct cccaagtagc tgggactaca 45720 ggtgtgcacc accacaccgg gctaattttt tgtattttta gtagagacag ggttttgcca 45780 tgttggccag gctcttgaac tcccaggctc aagcgatcca cccgcctcag cctcccaaag 45840 tcctgggatt acaggcatga gccaccacgc ccagcctgga tatctgaaat tcttaactga 45900 aattagtcaa attatcttgt actggggatt ttttttttaa tttcaacttt tatttttgat 45960 tcaggggata catgcatagg tttgttacat gggtatatca tgtgatgctg aggtttgggg 46020 tacaattgat cctgtcaccc aggtagtgag cataataccc aacagttgtt caacccttgc 46080 ccctctcccc tagtagtcct cagtgtctat tgatgccatc tttatgtcca caagtaaccc 46140 agtgtttagc tcccacttac aagtgagaac atgcagcatt tggttttctg ttcctgggtt 46200 atctcactta ggataatggt ctctggatgc atccatgttg ctgcaaagga cattatttca 46260 ttctttttta tggttgcata ctgtggattt tattgggtct ttattttgta ttagcatttt 46320 aaaaccctaa atgtgacaca gtacgcatga gtgatcatgc atctcaagaa atcttgaaat 46380 gttcctgtcc ataaagcaga attttttaag agaccatttc acagtctccc ttcccctcac 46440 tgtatcaagt gctcatttgt gaattaccaa tttctcttgt tttgacagtg gtattattca 46500 gcacgacttg attttctccc ttcaacaaac agaatgtgtc cttaaaccgg ttgaatcttc 46560 agatatgaaa atgactcagc tattcaccaa agttgaatca gaagatacaa gtagcctctt 46620 tgacaaactt aagaaggaac ctgatgcttt aactttgctg gccccagccg ctggagacac 46680 aatcatatct ttagattttg gcagcaacgg tgagtagtta tttttgttaa tcccctaaat 46740 tgtgtctgtt gctacaagcc ccatttcaac taaacattac tttacggttt ttgttggtaa 46800 tcatttggac attacaagct aatatatgtt tatagttttc ttaaatgtat ttgcttaaat 46860 atttttgccc ccgtaatttc ttaccattct tgctttttta tactgttgga aattgtgctt 46920 caaagtgtcc ttaaggtatt tcttcttccc acataaattt ttcctggcta ctctatttct 46980 gtatcctgct gtcagatttt ctccacagtt tagcagagtt atatggaagt aggcattgtt 47040 gcattaaagg ataaaaaagt agtcatacta taacatcaag cattgaagat gaaaactgca 47100 attttaaagt agagaacatt ttaatgtata aaaaggttgg tattgccttt tgtcttttat 47160 gccatagaga ttaagacgcg gtatcaatag tggattgtaa aggtaactca gacttatggt 47220 tatactatac tattgtatgt aaactttctg atgaaggaaa atttggtgac attttgttgt 47280 ttgatgaatt agacaaacct tttgtgaaaa agaacataaa ttttttatat gtgaaaatcc 47340 ttgtggccgg gcgcagtggc tcacgcctgt aatcccagca ctttgggagg ccgaggcggg 47400 tggatcactt gaggttagga gttcgagacc agcctggcca ccatggtgaa accccgtctc 47460 taccaaaaat acaaaagtta gctgggcgtg gtggtgtgcg cctgtaatcc cagctacttg 47520 ggaggctgag gcaggggaat tgcttgaacc tgggaggcag aggttgcagt gagccaagat 47580 tgcgccattg cactccagcc tgggcaacag agcaagactc tgtcttgggt aaaaaaaaaa 47640 aaaaatcctt ctatacttta gattgactca tattttttcc ccacagacac agaaactgat 47700 gaccagcaac ttgaggaagt accattatat aatgatgtaa tgctcccctc acccaacgaa 47760 aaattacaga atataaattt ggcaatgtct ccattaccca ccgctgaaac gccaaagcca 47820 cttcgaagta gtgctgaccc tgcactcaat caagaagttg cattaaaatt agaaccaaat 47880 ccagagtcac tggaactttc ttttaccatg ccccagattc aggatcagac acctagtcct 47940 tccgatggaa gcactagaca aagttcacct gaggtaggtg tcatgatata atcagaaagg 48000 gacaactttc agattttaac attcaagaat gtatttataa gtttgattca aacacttatt 48060 tgaaccacaa attacatttg tgtgtgtgtt tgaattttag cactttaaaa ttattgcaag 48120 agctactgcc taacctagac ctgagcacat gttttaggct caaagatagt caggaacatg 48180 ggaagaaact agcttaatat aaaccaaaag gtgaaacgta cattgtttct ctattattta 48240 tatcagtagg acaaaaacat cttgaatttg gacatttaaa gagaatagta ctaagtgtgc 48300 tcaaggtagc tacagcctat acctgttacc ccttttagtt tgttttattg tgttttgttt 48360 tgttttgaga aagagtctca ctatcaccca ggctggagtg cagtggtgca atcacagcct 48420 caacctccca ggctcaaatg attctcccac ctcagcctcc caagtagctg ggactacagg 48480 cctgcatcac catgcctggc taatttttta accttttttt gtgtgtgtgt gtggagttgg 48540 ggttctcact atgttgctca ggctggtttt aaactcctgg gctcaagcga tcctcctgcc 48600 ttggcctccc aaagtactag gattacaggc gtgagctacc atgcctggcc cattacccct 48660 ttgagttgga gaactgtctg gtagcaatag acttacgagg gtttaaatgg gaaaggacct 48720 tataaattct ttgcccaatt tagtctaatt tccatcacta ttttgaaatt ttgggtaagt 48780 ataatatgaa aataacaagt gttacataaa ataaatactt agtaactggt cttttttatt 48840 ctggatctgt cttgatatta attgtcctat gaacacaaaa ataatcttta aaggctaggc 48900 tggccaagac ttagagatat cacacagggc tctatttcta aatctagaat gattccattt 48960 tagggcttcc tacatctaaa aatatgctca ggagtagggc aacttagatc tgaacattat 49020 aacttgataa atgaggcata aataagcttt aataagtggt aaataattct acattaggta 49080 tttgttgaat aaaactgaca agctaagagt aggggatttg acatctcaca gccttgtgtt 49140 gaatgaatat atatcctatg ctctggttgc ttaatttacc cagaaaaaaa aatgtttgat 49200 tcatcttggt ttttatctaa caaaagtaaa tctaacaaaa acgttagaat gaggaaagca 49260 aaatttcttg tttagaatac acagctatag ttttttgtta aacttcttgc ccagaactct 49320 taaaatagta ataatgtaca ttcgttcagg tatatgcagg taaaataact taggtttcta 49380 ctcccacccc cgacagtaac agtgagattt ttaggtagct cagtcaccac aggagtgtgc 49440 cttctcagtt caaaggtaaa ttccagtgaa tgtagcatct agttaattgg tcaattaggt 49500 accattgtgg gatgtgaatt accaaatagg ttttattctt tagaataagg tgtttctttt 49560 catctcaatt ttgtaaatga tgttatatta catagtcaga aatatatata ttggcaaaat 49620 tagttaccag tataagcttc aaaatgtcac tattttcaca aatttttttt tttttttttt 49680 tttttgacat ggagtctcac tctgtcgcca ggctggagtg cagtggcatg atcttggctc 49740 actgcaacct ctgcctccca ggttcaagtg attctcctgc ctcagcctcc tgagtagctg 49800 ggattacagg cgtttgccac catgcctagc taatttttgt atttttagta gagacgaggt 49860 ttcaccatgt tggccaggat ggtctcgatc tcttgacctc attatccctc caccttggct 49920 tcccaaagtg ctgggattac aggcgtgagc cactgagccc ggcctagtta aataaaattt 49980 gataaacacg atggacttgg ttgtgtgttt tctggttttt ctgagatcta gtttgaaaat 50040 tctgacaact agcaaagtat atggaagctt cttcaggaaa tagtaaacat atttcttttt 50100 acagcctaat agtcccagtg aatattgttt ttatgtggat agtgatatgg tcaatgaatt 50160 caagttggaa ttggtagaaa aactttttgc tgaagacaca gaagcaaaga acccattttc 50220 tactcaggta tatgaactta tttgttttat attaaatttc attaattttt agtctgaagt 50280 gactttgagt ttcacttgtt ttttatttat aaggtgtggc cattgtaaaa actcatgtat 50340 ttgctgtttt aaaggacaca gatttagact tggagatgtt agctccctat atcccaatgg 50400 atgatgactt ccagttacgt tccttcgatc agttgtcacc attagaaagc agttccgcaa 50460 gccctgaaag cgcaagtcct caaagcacag ttacagtatt ccagcagact caaatacaag 50520 aacctactgc taatgccacc actaccactg ccaccactga tgaattaaaa acagtgacaa 50580 aagaccgtat ggaagacatt aaaatattga ttgcatctcc atctcctacc cacatacata 50640 aagaaactac tagtgccaca tcatcaccat atagagatac tcaaagtcgg acagcctcac 50700 caaacagagc aggaaaagga gtcatagaac agacagaaaa atctcatcca agaagcccta 50760 acgtgttatc tgtcgctttg agtcaaaggt atttatatgt aacattcaag ttatagttct 50820 tttattattt ttgagataaa tgtatgtgat agtacatgat ttttaaactt atagcaaact 50880 ttctgatata tatgccctaa cgcaaattct tgagaactca aaaaactttc taaattaacc 50940 tcatatattt tttctttttc tttctttttt ttttttttga gacagagtct cgctttgtcg 51000 cccaggctgg agtgcaatgg catggcacca tctcagctca cggcaacctc tgcctcctgg 51060 gtgcaagaga ttctcctgcc tcagcctccc gagtagctgg gattacaggc atgcaccacc 51120 acgcccggct gatttttttg gtatttttca tagagacagg gtttctccac gttggtcagg 51180 ctggtctcaa actcccgact tcaggtgatc cgcctgcctc agcctccgaa agagctggga 51240 ttacaggtgt gagccaccat gcccgctcct attttttcta aaataattat aaattctaaa 51300 attacctatc taaatggagg agggtcttct gacaccttta aaataaaatc cagctcagta 51360 ctgtaaatgt gtttacagaa cttgtttaaa gttcttacag ttgtttaaat cagactagtt 51420 aactaccctc actacttaga tgcttccatt tcttagagct cttttttaag cttatctgaa 51480 gaaaagccct tccaatttaa gggttatttc caattgcaca ttccaaattg agccttccat 51540 cttcagcatt caatatagat atttacaggc ccctctttta aaattttatt atagttaact 51600 tgtattaaag ttgcttttat ttttcattac gtatttgtag aacattagct atatatatat 51660 tgcaggctac ataggttttc aaactgtaca acaggaatct aagcatgaat tgttacttct 51720 atggagctag ttcaaacaaa catatggaca tgacccaatt tttaagttat actttctgta 51780 tataatttgt aaggggattt cacatatttt aagtttgagg ctatagctag aagaaattaa 51840 gttttatcta ataagtgtgt ggaaaaggga aatgattcct tctctactat gtctagacta 51900 agccagatat caatagcaat aggaaagaac cactgtcgta gccagaacac atagcttttt 51960 tccctgccta acattcccac cttgacctag agtgctggga gaggtctttt ccctaagctt 52020 ggaaaagaca ttggggcttt agatgaactc agaagtactt tacattactt tatttactgt 52080 gtcacttact cacttttgac tctgagctcc acgagggcaa tcacagtgtc ttgggcattt 52140 tagtgatact aatacttagc tcatgaccta atgtgtagta cttcctcaat aaatggttgt 52200 tgaggcaggg cgcagtggct catcactgta atctcagcac tttgggaggc tgaagcgggt 52260 ggatcacctg aggccaagag tttcagacca gcctggccaa catggtgaaa cccggtctac 52320 taaaaatgca aaaattagct gggcgtggtg gcacgtgcct gtaatcccag ctactttggg 52380 aggttgaggc aggagaattg cttgaaccct ggaggtggag gctgcagtga gccgagatcg 52440 tgccattgca ctccagcctg ggcgagaaga gtgaaactcg gtttcaaaaa aaaaaaaaaa 52500 aaaaaaagtt gttggactga cagatgcatg aatacagtag taaaaatgac aatcacttat 52560 aagttacagt ttactatcag ctacagagga tgggatatcc agttttctga acaactgttc 52620 tcttgtactt gtcaaagcca aagtgtaaca acacatcaag tcactttagc aatttatttt 52680 tgagacggag ttttgctctt gttgcccagg ctggagtgca atggcgtgat ctcggatctt 52740 ggctcaccgc aactgccgcc tcgctggttc aagcaaatct cgtgcctcag cctcccgagt 52800 agctgggatt acaggcatgc accaccacac ccagctaatt ttgtattttt agtagagaca 52860 gtgtttctcc aggttgatca ggctggtctc aaactcccga cctcaggtga tccacctgcc 52920 tcagcctccc aaagtgctgg gatgacagtt gtgagccact gtgcccagct agcaactgtt 52980 tttaaacatt agttccaatg tagtgtacac tgaaaacttt tatgaaagga atttcaaaaa 53040 ttaagataaa ccattaaaaa cgtaattact aagtactact actactacaa tgatatttac 53100 ataatagact gagttacatt tcataaagac aatatatctg tataagaatt tttaaacttc 53160 cctgtctata taatagaagt tttagagaaa ttttttaaaa accaaagaaa actgcaaaat 53220 aagatcactt acctatttgg cattctcaac tgtctggaac agcaaggagc cattatgatt 53280 atgcatttgg tttgtggggt gtcttgaaaa gtcaaaataa tgtaacaaag ctgatgtact 53340 ttactcatta gaacaattct tcacaattta atattaattt tagatataca tagttcatgt 53400 ttgataacca gatcaatact gagtgaaaaa tagcatagtg ggaagagcag gggaggggag 53460 gtagggatct ggagacctag agtgtacttc catattgcaa ctagtgagca gtaggacttt 53520 gagaaagtta cccaataggc ctcagggttc taatttataa aatgggtatg atatgcctgc 53580 cttatctgtc ttgggaactt aagtaaggtt aaaatgaact aatgaacttg aaatgtttta 53640 taaactgaaa atgctatacg aatgtgagat tgatcttgta tttcaatagt cccaacaata 53700 tcactgcatt gttatattag gtggaataaa aggacaatat ttaactgttt tgactctaca 53760 atagtgtcaa tttagttgtg ttcagctcta ttttataaaa tagggatacg catactgtag 53820 aaaatttcct gttaaattaa gctttgacgg ccaggtgctc acgcctgtaa tcccagcact 53880 ttgggaggcc aaggtgggca gatcacttgc gctcaggagt ttgagaccag cctgagcaac 53940 atagtgaaat cctgtctcta caaaaatatg tatatataaa ttagtcataa tcccagctac 54000 ttgagaggct gaggtgggag gatcacttga ttccagaggc agggcttggt tgcagtaagc 54060 agagatcacg tctctgcact ccagcctggc tgacagagta agaccgtgtt tcaccaaaaa 54120 aaaaaaaaaa aaattaagct tttactttta agatgataaa ctttagtgat caggaaagtt 54180 atcttatgta tattatattc cttaatattg gagaactaaa gaattatgta ttttctttaa 54240 aagcgctcac tggatatttt ttttaaaaac gctatatttt catttagaat ttttttcttt 54300 tcagaactac agttcctgag gaagaactaa atccaaagat actagctttg cagaatgctc 54360 agagaaagcg aaaaatggaa catgatggtt cactttttca agcagtagga attgtaagta 54420 tgagtagtag gttttgcttt tctagctaat gtgctatttc gtgtgtgtgt gtgtgtgtgt 54480 gtgtgtgtgt gtgtttccac gtttcttcca aatagtaaag ttatattttc agaagttata 54540 cattgggttt ttttactctg tatgcactgg tttttaaaaa tacaaatgtt taatacatac 54600 attcttggta taaaaattcc aaacaattcc agtgtatttt gagttaaaaa gtgaagttct 54660 ccccttactc caccctgaat atcaccacca atctcattct cttcccttta agttactttg 54720 ccttattaaa agaactgcta ttggccaggc acagtgcctc acgcctgtaa tcccagcact 54780 ttgggaggcc aagatgagga tcacttgagg tcaggagttc gagaccagcc tggccaactt 54840 ggtgaaaccc tgtctctact aaaaatacaa aaattagcca ggcgtgttgg tgcacaacta 54900 taatcccagc cactctggag gctgaggcag gagaatagct tgaacccggg aggtggaggt 54960 tgcgatgagc tgagatcagg ccactgcact ccagcctggg taagagagtg agagtccatc 55020 tcatatttaa aaaagaactg ctatgttttg gggtaagtca atggtggtat aatacattct 55080 gatattttca aactaaatta actggaaagt atttatagac agaatggtca taatggatga 55140 caaataactt aagaaagaat tcaaaataat ttagggtagt atttaagaaa ctgcctataa 55200 tgttattaaa tttacaccaa tttcaaggtt tttggttgtt taaaaaaaaa attcaacaaa 55260 ctaaacttga aataacttta ctgtttatag ggaacattat tacagcagcc agacgatcat 55320 gcagctacta catcactttc ttggaaacgt gtaaaaggat gcaaatctag tgaacagaat 55380 ggaatggagc aaaagacaat tattttaata ccctctggtt agtttattct ttttgacctt 55440 gaacatcaca aagacaaaat acatgaaaca tttttattta ggagctttaa tctaagtgag 55500 aatgactttg gttccttagc aagattaaaa agtaaagttg tggctgggcg cggtggctca 55560 cacctgtaat cccagcactt tgggaggccg aggcagccag atcatctgag gtcaggagtt 55620 ggagaccagc ctggccacca tggtgaaacc ccgtctctac taaaaataca aaaattagct 55680 gggcgtggtg gcgggcgcct gtaatcccag ctacttggga ggctgaggca tgagaattgc 55740 ttgaacccgg aaggcagagg ttgcagtgag ccaagatggc accactgcac tccagcctgg 55800 gcgacaaggg tgagactctg cctcaaaaaa aaaaaaaaaa aaaagtacag ttgtatttca 55860 tgtgatggtc ttaatacaga gattaacatt tcaaggtgga gcttttcatt tttagtaatt 55920 ttctttgatt tctctatgtc catgtgctgt caatattgat agaagctgaa atttgtgaac 55980 ttttatgact tctttttttt tttttttttt ttttgagaca gggtctcgct ctgttgccca 56040 ggcctggagt gcagtggcat gatcatagct cactgcagtc tcaaactcct gtgctcaagc 56100 tcaagcaatc atcctacctc agcctcctga gtagctcgca ctacagacat gcctcaccac 56160 acccggttgc tttttgtaga gatggggtct cactatgttg cctaggctgg tttcaaactc 56220 ctggcctcaa gtgatcctcc tgcctcagcc tgtgctagga ttacaggcat cagctttgat 56280 gcccaccata tttatgcctt tttccaaatt gttatttctt tgtgccttta ttgtatcctg 56340 taaacatttc tgacacagca acagtatcac tggattatac ttacttttta acatagttgt 56400 ggttttgcca ggtaaactaa aaacccttcc agaattttgc tttattttct atgataccta 56460 acacattgtg ggtgtttaat aaatattcat tgactagatg aatgtatact taggtatctc 56520 ttttgttttt cagatttagc atgtagactg ctggggcaat caatggatga aagtggatta 56580 ccacagctga ccagttatga ttgtgaagtt aatgctccta tacaaggcag cagaaaccta 56640 ctgcagggtg aagaattact cagagctttg gatcaagtta actgagcttt ttcttaattt 56700 cattcctttt tttggacact ggtggctcat tacctaaagc agtctattta tattttctac 56760 atctaatttt agaagcctgg ctacaatact gcacaaactt ggttagttca attttgatcc 56820 cctttctact taatttacat taatgctctt ttttagtatg ttctttaatg ctggatcaca 56880 gacagctcat tttctcagtt ttttggtatt taaaccattg cattgcagta gcatcatttt 56940 aaaaaatgca cctttttatt tatttatttt tggctaggga gtttatccct ttttcgaatt 57000 atttttaaga agatgccaat ataatttttg taagaaggca gtaacctttc atcatgatca 57060 taggcagttg aaaaattttt acaccttttt tttcacattt tacataaata ataatgcttt 57120 gccagcagta cgtggtagcc acaattgcac aatatatttt cttaaaaaat accagcagtt 57180 actcatggaa tatattctgc gtttataaaa ctagttttta agaagaaatt ttttttggcc 57240 tatgaaattg ttaaacctgg aacatgacat tgttaatcat ataataatga ttcttaaatg 57300 ctgtatggtt tattatttaa atgggtaaag ccatttacat aatatagaaa gatatgcata 57360 tatctagaag gtatgtggca tttatttgga taaaattctc aattcagaga aatcatctga 57420 tgtttctata gtcactttgc cagctcaaaa gaaaacaata ccctatgtag ttgtggaagt 57480 ttatgctaat attgtgtaac tgatattaaa cctaaatgtt ctgcctaccc tgttggtata 57540 aagatatttt gagcagactg taaacaagaa aaaaaaaatc atgcattctt agcaaaattg 57600 cctagtatgt taatttgctc aaaatacaat gtttgatttt atgcactttg tcgctattaa 57660 catccttttt ttcatgtaga tttcaataat tgagtaattt tagaagcatt attttaggaa 57720 tatatagttg tcacagtaaa tatcttgttt tttctatgta cattgtacaa atttttcatt 57780 ccttttgctc tttgtggttg gatctaacac taactgtatt gttttgttac atcaaataaa 57840 catcttctgt ggaccaggcc cctttgatca gcttttatgt tcaaatatta ataatatttg 57900 cttcaacacc tccaactcat aaaattgttt accaacaatt taagcactta tgaaaattac 57960 atggtactgg ttatttctac atttatctta gtgccatcac cttaatgtat gttgagtccc 58020 taaatgtcat gttaaataat aacaaccata atatcccatt gaaaagagta tgttgttaga 58080 aaagaaacat catttttaag tttctgagcc tattaaaatg ctcaaacaca aaatattagt 58140 atttttaaaa tatgaatggg atgagtgaag cagttctcag cattatagtc acaatgttac 58200 aaaggctaga gcttctctga agatttctaa tctgttccca ttaacagatt aataaattta 58260 gacttcaaat gaataatttg cccaagcttt aaaagtaata gatggcagac caaaaatgta 58320 agcttaagtt tcctgactct aaagtcaaac ttagaacaaa tttggtttgt ttttgtttta 58380 atgatactgc gttttaaaac aaagtagctt tatccttttt ctcctgtatt tttcttttac 58440 aaaatagctg tatttctttt atactgataa tctcattttt aaaaatcaga cagtgtagaa 58500 agatattttt taaaacagaa aaatcactat gaatccctgc acctacaggt acagaaaatt 58560 atttttatga acaaattatg taggaagtgc cagagcctta ggtcctttac cctgaggtat 58620 atatactgaa caaaaggaac tgagccacag atctcttagg tagctctttt tatcttacaa 58680 tggaggacag tgattacaat tatatgaaaa ttttggaaca aaagttaata ctaagattca 58740 gtgcaaaatt tggggggggg gggggcacag gtatacttaa gcacaaacac tgtgacccaa 58800 agtgcttcaa catttagtta cagatagtag tatactagaa gtggtatttt agaataaagt 58860 ggttgcttag tattcacagg tcacaaaaca aaaaattatt cttgtatagc aaattagctt 58920 cagttgaaaa ctatttgtaa aagcagatta tgtaatgacc aggagttcag gaaaatgact 58980 tctgaaagca ttgagaaggg aaagccacgt taaaggacag tacagctgga aggaagcaag 59040 tacttaccca ctgctcagtc actaagacaa caagctcctt ggagtgcttt aagctacgga 59100 atagcagaac tggcccttcc caattttatg caccgtcaca aatttcttca taatggtttt 59160 gtccaaggct tataacccaa ccctggcaac tataatcctt actttatgaa acagctgtat 59220 ttcttttata ctcataaccc agaaaaatga gaatgtatgt tctgagtata aaagaaatgt 59280 agctattcca taaaaataca ggagaaaaag aataaagcta ttttaatttt tttaatgcag 59340 tatcattaaa aaacaaacca agtttgttct aagtttgact ttagagtcag gagacttaag 59400 cttacatttc tggtctgcca tctattactt ttagagcttg ggtaaatctt catttgagat 59460 ctaaatgcta tatatagttc attcatagca gtaccagata agggaggagt atatctatac 59520 agtatatagt cttgaagaag tgatctaagg ctcggagctt ttgaggtggc catgagtgac 59580 tccaaagtcc atggagctaa ccaccctgca gtgctagcca atccagttga acataccctt 59640 ttctccattg ttaactgttt gtttaaatag caaacagaag gcggcaatgg aggtgtggaa 59700 aactgaggat ccgatgtcac ttgaaagtaa tgagatcaca taacattgag ggaatgtcct 59760 aagaggagtg gcagggcata aatagaaatg aataaaagtg ttttcaagtg ccatttagtg 59820 ggttctgaat ttgaactaga gattgagata tccagttat 59859 <210> 30 <211> 26277 <212> DNA <213> homo sapiens <400> 30 tatgcttatg aatctattta attgctcaga ctgtgctaga gaatacgtac catgaaatac 60 atatatttca taaggttcag ttacaaaatg gattgtttca aatggcaatt tcttacacta 120 acctgattat gaaaaaaaga agtctgtatc atctgcttcc aagtctgtta tgtccaaata 180 tattttaatt atgcatttat tttgctactt ttataaatat tagagatttc accttaaatt 240 atttttgtaa ctagttctag aacatgtttt ccaattatta tttttctaat ggagacatat 300 aattgaccta tgtttatgca tatatgttct ctacacagtg aaactttttt taaaaagaat 360 agtaaagaaa atgcggaagc tctggctctc caaggcaaag tcaaaaaaaa aaaaaaaagc 420 gggggggaat gcgaggaaca ttttattaca cctcctgatt ttcagtcctt gagttttatt 480 ttctcccctt gtttatttgt ttaatgctag aaactgtatt cctaagagag catacctctt 540 tcaggtgagc atgataattg gaagattttg atacttagag tatgaacata taattaagaa 600 gtgattacct aataaagata acaatgtgac tattttaatt attttggtgg cagggagttg 660 gttttacatc acccaaaaaa aaaaaaaagc cctggtttca aattcattgg taataaatat 720 gctaactttc tgaatcaaaa tggagagcct ctcaagaaaa agagctatgc agtcagcaat 780 gacttaaatt agtcaggata gcaggcatct ggggttaagg ctgtttccac cattttggtc 840 tcaccaccat atacgagtgg gaccacagct gtgtagcact tgtttctgtc ataagtgtag 900 caggtctctg tagcactgtc ttcatcacag atattgctct gggtagcagt aactatctga 960 ttatccagct ccacttctgt aggatcacat tttttacagc tgaaaagcaa atatatgtat 1020 tagacaatcc cctcaaatgc tgtctcaaaa tgtgactaca catttcaatc caaaatcaat 1080 tagttcttgc agctctgaca tgacagcaag ggatgactcc tttcagacat aagcagctct 1140 acaatacaga atagcttatg ggattttcca atctttaata tatattagtt gaaagtaagc 1200 aatataatta atgatatgat aatatgattg ttttatctac accatacagc aatttctact 1260 gtgttaggct tattcccaac tgtatatctg tctaaacaag ttatttatag tgacaagaaa 1320 gggagaattt ttaaaaaaat tgatgttgga gtctgtcatt tccaaagaaa cacctgcctt 1380 tttataagat caaatccact tattgaacta ttaagagaaa ttggcctttc tatgaatgcc 1440 aatgattttt tctttagaaa aaatgtatag ctaaatttta tctgtgacaa agttttatga 1500 atttatgata cctaataatt aacataggaa ttaatgtatt caaaagttca gattatgttt 1560 gtaaatgttt atactccaac atatttttaa aaacattctt actaacaagg ttaaaattaa 1620 aagctattaa cttccacatc tatattacta tggaaaaaaa tatatcttac aggtcagaca 1680 aatggtacac aaatctggtt ctcaatggtg aggtgggatc agagatattc tccctgttgt 1740 tcagaggaac actaaaagaa aagaaagaaa acaaagttaa aacaatgaaa tgcagatatt 1800 gttatttttg gtaatgagta tacggccact atttcatcag aacagtactt attgtattta 1860 gtactctata agcactctag agtaataccg ttactcagat ttttatagta acttgctata 1920 ttttaaatat ttctcattca aaataaacct cacaacaact ccgctgtcaa ctatctttgc 1980 tgacttggca aatttttgct tttcctttaa aactcaactc acgttttacc tctgtaataa 2040 ttatattgat gttatcccca cccttcaaca aacttcttcc tctgcagtct cattaatgct 2100 catatatatt tattatatca aatgccgtat catagttgct tgtctacaga gtggttgctt 2160 ccctgggcta tgtaagttcc ttgaggcaaa aacatttatg tattcccagt gcctagctag 2220 gtatgtggca tatggaatat gttcaatata tgtgaaatgg acagacagat attattatcc 2280 agattttaga ggagaggaaa tcataaatag gagaggttag tgatccaccc aagttcacac 2340 aacaattaag tagcaaagct ggaacttttt catcgtgatg tcccatgaaa aattagatga 2400 ttgtcaacga gttcaggtga tttcattaac tttaacattt ttttcatcta agtcatcatt 2460 ccttctcatg tgcagccctc cctaccaaaa ggaacaacaa aaaccttgtg tttcctaact 2520 cagtatttat aaataccatc caagccaaaa acctggctat catacctgaa tcctcccctg 2580 tcacatatct aatcaatctc acagtccagt tgattctaat tattttcatg tgtgaaatcc 2640 atccacttgc ctctcttctc attattactg ccttaattca ggacaccact atcctctcct 2700 agattgtaac aatgtcttcc ttttgtcttg accccttcaa accactggcc acattattgc 2760 caaacatcct ttctaaaaat gcaagcttaa tttccttctc tgcttaaaac ctctagtgtc 2820 tctccacaga taacagggta tcctcaaata gcatagaagg cacgtatcct aatatgcccc 2880 taactctcca gcttcatctc tcacaatgtc accatctaca atgcatgcca gctgtaaaca 2940 atcacttgca attccacaaa cgtaccatgc ttttctcatc tcccatctta acaataacag 3000 ttctaacata taatactggt tacagtgtgc ctggtactat gctaagcata ttacgtgatg 3060 atctcatata atcgtcacag caatcctgtt tccttttcct ggaatgacct gccccaccta 3120 ttaattctct cactccccac acacatttag ccagcaaact cctattgagc taacagccat 3180 catccatccc accacttatt ccaagcaccc tttcctgcct cccactgcca cccttctcct 3240 ctcccccagg attggactgg gtgcccctcc tcagtactcc tataacaacc catgcccatt 3300 cctatcatag cacttacaat acagaattgt aattgccgtt ttaattgttt acggtttcct 3360 gttagactat aaattctttt aagaaatgga ctatatttta aataaactgt tttatcccca 3420 ccaccaaccc ttaatatttg gcagttacta aataaacatt cgttgaatga atgaatgaaa 3480 ctattcttaa taagactgta aagactctag taatatcaga aaaaggagag gctactataa 3540 gccaaacact gttcttttat gaattattgt atttaatcct cacaacccta taaagtatat 3600 gtgtataaat tcatacatgc ataattatcc ctttttttaa agtttaggaa aaaggctagt 3660 taagtaactt gcccaaagtc acatcatttt agtaagtaat ggagttggga ataataccat 3720 aatggcaggc tcggcatggt ggctcacgcc tgtaatccca gcactttggg aggctgaggc 3780 aggtggattg cttgaggtca ggagttcaag cccagcttgg ccaacatgat gaaaccttgt 3840 ctctactaaa aatacaaaaa ttagccaggc gatgaggagt gcatatgtag ttccagctac 3900 tagggagact gaggcagaag aattgcttga acctgggagg cagaggttgc agtgagccaa 3960 gatcatgcta ctgcactcca gcctgggcaa cagagtgaga ctctgtctca aaaaaaaaaa 4020 aaaaaaaaaa aaaaaaaaaa gccaggcacg gtggctcatg cctgcagtct cagcactttg 4080 ggaggccaag gtgggcagat cacctgaggt caagtgttcg agactagcct ggccaacatg 4140 gtgaaacctc atctctacta aaaatacaaa aaaaaactag ctgggcatgg tggtgcgtgc 4200 ctgtagtccc agctactcgg ggaggctgag gcaggagaat tgtttgaacc caggaggcag 4260 aggttgcagt aagccaagat cgcaccactg cattccaacc cgggtgacag agggagactc 4320 catctcaaaa taatgataag aataataata ataataccat aatggcacag caatggcaat 4380 atactttcag aaatcagaac agaagatcaa cacatcaggc aaagtgtcat gaaatatctg 4440 aattatctga tttcagtaaa caatgtaata taaaaagaat catttcataa aataaaaaga 4500 tgaattagaa gatcatggag gagattttaa aaatctcctg gaggtttaaa cgtaagatag 4560 acactcttca acatggctta agtgccagtg tcatgtatgc cattctttcc aattacccac 4620 tactccagct attctatccc taacacgaag ctatgtgggc aggatctgag tggtcaaaga 4680 aaacctccta gaggaagtga tggctgaact aagacatgca cattgagaag gagttaacta 4740 ggctaagagg ggtgggacag agttcttcaa acagaggaac tagcagatgt aaaagcactg 4800 tgaatgtggg gaaatagaga cactacagca gtgctgaatt tttttttttt tttttttttg 4860 agaaagtctc gctcttgtcc cccaggctgg agtgcagcaa tggcatgatc ttggctgact 4920 gcaacctccg ccttccgggt tcaagtgatt ctcctgcttc agcctcccga gtagctggga 4980 ttacaggcac ctgccaccac gcccggataa tttttgtatt tttagtagag acggggtttc 5040 accatgttgg ccaggctcgt ctcaaactcc taacctcagg tgatccaccc gcctcggcct 5100 cccaaagtgc tggcattaca ggcatgagcc accgtgccca gccccagtag tgctgaattt 5160 ttaaacatga agtaaaagaa aagtggcaat ggatgatctt gagagttatg ctaagctttg 5220 tagatcaggc caaggcattt gtaatatatc ctaaggtcaa tgttggggaa accatcacaa 5280 gacttttaag caggatggtg acaataattg gcacatagat taggtgaata aataatagta 5340 aatatttttt aatatgtccc agaaatatat aagctctaaa aggaatattc tctatttatt 5400 tttacaataa tcctatgagt taagcatgat ttttttcctc atttaaagat gaaaaagttg 5460 aagttcaaag tagattagta acttgcatac aaaaacacac aactattaag tgtcccagac 5520 agaacttaaa acaaaattct taaacacatt atactttttc cattgattga atggaatgga 5580 atgctctgtt ctctttctat aggagatttg attggggaaa aactattaag gtaggagtgg 5640 tttacaagga aaacttataa ctgattggat ccaatagaaa tctaatttct caaatagtat 5700 tagcattctt gctattgaaa aagagctgta tagcatataa ctctggactg tgtgtgaaat 5760 gaaatgaata tctgaaatcc aatctaaaag tgagatcaaa tcaaattaat gtgatcagtc 5820 tgccttatct cgatgcagac atctggttac agtataaaag actcagttat ctatatatgg 5880 tacaaaataa ggctttagtg ttatctgaag tttcagtttg aactgatcaa aggcaactga 5940 aagttctgat tcaaattgaa ataacttggc caggcgtggt ggttcaggcc tgtaatccta 6000 gcactctggg aggccaaggc aggaggatcg cttgagctca gaagttcgag aacagcctgg 6060 gcaacatagt gagaccctgt ctctaaagaa aaataaaaaa ttatccaggt gtggggtggt 6120 gcatgcctgt agtcccatct actgaggagg atcacttgag cctgggagtt cgaggctgca 6180 gtaagcagta atcttgccac tgcactctag cctgggtgac agagtgagac cctgtctcaa 6240 aaacaagcaa acaaaaataa atgaatagaa ataactccat ataaacagtg catgttgatg 6300 actagattac aacctttgtt tataatttga tgtagcccac tgattttaga ttggctgtaa 6360 tctttcattc ttacccctaa tttcaataaa attgcctcaa gctcattcat aagactcaat 6420 tctttactca tgtaaagtgc tacacagcaa aaaggggagt aaagaggcag gtgttacatt 6480 caaacaatgc tcagtgtcag aaagtatctc tgcttagaac aggaaaaaaa ggaatatgga 6540 atgccacata cataattcgg atgtttctct ccacaatgtc ctcattagga tcttcggaag 6600 aacggatgat cctggaagta atccgggcac acttacattt gttgtcaaca agaacaatcc 6660 tttcatcttc ttgggcttga aaggtaaacg tattaaaaag aaaggaaaac aaaggtcaat 6720 ttatatattt tgtattgagt tattttatct ttcttgcctg cagaaaaata gttttatggt 6780 tggtttgtct cagctttctc catttgttct ctaagcagaa tcttacatca cagtaaagga 6840 aatccaaagg tactctaaaa gggattttca cttttttctt gaaccagtct atgggaatct 6900 gggttgaaag aattctgatt ttcgcatcct tcctaaactc tcatttgtac ttaaattttt 6960 tttgtataaa ttgtattata gttaagaaca ggcatgtttt catccaagat aaccttattt 7020 tgtaagactt ttaaatattc tctaccacaa ttatctgcct tttcataata acaatcagat 7080 tatcatagta catgattcaa tttaaaaaaa ggctatattt cttataagaa ttattttaag 7140 cagggcgcag tggctcatgc ctgtaatccc aggactttgg gaggccgagg cgggcagatc 7200 acagggtcag gagttcaaga ccggcctggc caacatagtg aaaccccatc tctactaaaa 7260 acacaaaaat tagccgggca tggtggtgca tgcctgtagt cccagctact caagagtctg 7320 aggcaggaga atcacttgaa cctgggaggt ggaggttgca gtgagccaag atcgtgccac 7380 tgcactccag cttgggcaac agagtgagac ttcatctcaa aaaaaaaagg aaaaaaagaa 7440 ttattttaaa agatagagta tatatagata taaagtgctg taaatttgca aaagcaattt 7500 agaaatatta tgaggtacaa tctcaattga atatgcctgt atacagaaaa aaaaatgaat 7560 aaatgaataa atacacatat gaccattaaa gccttaactt tgaatgtcaa catttattgt 7620 ctaatctgaa tattagacaa agaggtctga taagttgttt gtttatttgc cagaatgtct 7680 cactctgtca tccaggctgg agtgcagtgg cacgatctca gctcactgca acctctgcct 7740 cctgggttca agtgattttc ctccctcagc ctcccaagta gctgggacta caggtgtgca 7800 ccatcacacc tggctagatc tttgtatttt tttttagcag agatggagtt tcaccatgtt 7860 gcccaggctg gtcttaaact cctgacctca agtgatccac ctgcctcgag cctcccaaag 7920 tgctgggatt acagagccac cgcacctgac cttgataagt attgcaagga ataaacaaag 7980 gaaattttgt atcatctggg tttggatcaa ttaacagatt ttattttaat tttatttttt 8040 gagacagagt ttcactcttg cccaggctgg agtgcaatgg cgtgatctca gctcactgca 8100 acctccacct cccgggttca agtgattctc ctgcctcaac ctcccaagta gctgggatta 8160 caggcatgtg ccaccatgcc cagctaattt ttgtattttt agtagagacc gagtttcacc 8220 atgttggtta ggctggtctc gaactcctga cctcaggtga tccaccctcc tcggcctccc 8280 aaagtgctgg gattatgggc gtgagccacc acgcctggca aattaccaga ttttaaaaat 8340 tcaataatag ctttacataa gtaatgctat taaataagag tgctaattaa taataacaat 8400 gatgttggcc gggtgcagtg gctcacgcct gtaatcccag cactttggga ggccgaggcg 8460 ggtggatcat gagttcagga gttccagacc agcctggcca atatggtgaa actccatctc 8520 tactaacaat acaaaaatta gccaggcatg gtggcacaca cctgtaatcc cagctactcg 8580 ggaggctgag gcagaagaat ctcttgaacc tgggaggtgg aggttgcagt gagccaagac 8640 tgcaccactc cactccagct tgggcaacag agcgagactc catctcaaaa aataataata 8700 ataataataa ttacaacaat gatgttaaat atgctttatt catataattt tagctaagtg 8760 acctttaaca attcctctca ttaagcctca actaaaaaaa aaacatttag tatacgaatt 8820 caagttataa agtttaaatg atcagaatag ttataatttt aactggaagt ctattcctga 8880 gacgattccc agagcaaaga ggacctaatg cagtatttca gtcttaatga taagagccac 8940 tacaaaaaca ttttaagacc attgttattg tacttgtaat tgtttgaagt actttataat 9000 gcattattat accattattc ataagttcct aatgaatctt ctgacactgt gtaatattgg 9060 aaagaaacat tatggagtaa attcaaggta atgaaataac tcattaacat ctgaaagagg 9120 taaaatgact taaatgatgt cctctttcct acttgtgtat ccatgactct taaaagtttt 9180 ttctcaatga aatataaatg agcacataat gcctgaccaa aaatatagat tgttgaggag 9240 tgacttgact attaagtctt aaatagaaaa tgtctatatt ctattacggc atatgattac 9300 ttccttacca gaaacctggg aagttaatat agaaaaatat taggcagcct aatatctatc 9360 agaaatacat agctgtcaga aaagttacaa atactttcaa ttcaccaaga cttagagtct 9420 agcatttgct ctcaccaaca ggcagtattt ttcctaacaa acctgttatt agggactgtg 9480 ccttacttta ttccaagagc atctgacaca tagtaggtgt tcaataaata tttgttaaat 9540 ttaattcact tcaaacaaat aagaaaatag atttaacaac atatgctaga tatgaccata 9600 atgagtttac taaaaagtga ttgccttaca caaggcagaa taggatagta ggagtgcggg 9660 ctatagggtc agattgcctg ggttctgctt acactcttgc ttgctgtatg actttggtaa 9720 gttacttcac ctctgtaagt ctcaactggc tcaactgtat gtcagaagta ataatagtat 9780 ttattctcat atggttactg agagaattaa atggaatatt atatgtaaag gaattagcat 9840 gatacctaga atatcatatt cagtaagtga tagctgtttt atatacagat ggtccccaac 9900 ttaccatggt tctacttatg atttttctac tttatgatgc tgtgaaagtg atatgtattc 9960 agtatgctcc tcagctacaa tggggctacc tccctataaa gtcactgtaa gctgaaagta 10020 tgatattttc aactttcaac tttatagggt ttatagggaa gtagccccat tatatatatc 10080 atatattttt agatatgtat atatacttac attgtacatg ctttactaat attttatatt 10140 ttaaatcatt agaaagttat tcttaatgct aaattagtat aaaatatata tataaggcct 10200 attcttaatc acatttctgt cattattcat cttgaaataa gaaccacaga ctcagtgata 10260 ggaacaatcc agacaaattt tagtgtgtcc ttctaaatga aaattattta atactgtacc 10320 tctaaattca gaatgtattc cattttctga agttgtttga aagatcagta aacaaaataa 10380 caaaagttca gtcatcaatt tataggcaac ctgtataaca ttaaacattg ttaaagggtc 10440 ataataaatc tgtgggatca gatccaggaa agctgttaaa accaatacca gcctctttgg 10500 ggaaataaaa tcccaatgca ttccatgttg tacttacagt aattattatt tcatttctcc 10560 agaatattaa tttaagagac tcaagggaag gattatagat ttttaagatt caatatggac 10620 attcatataa gcaggactat ctgtagttag ctaatttctt attctctagt ttgtagtagg 10680 caaacaagta agtaagataa gagaaaaaag aataaaaaga gtcttatcta tgtaaagaca 10740 actgccatag aaagatgaaa gcatgttagg aaaaagtagc tggctaactg gccaaccaaa 10800 gcataggcat aaatgtttaa aactgaaaaa cagatctgtc ctatattttt cctttgatct 10860 gggatcattt tctaaatatc acataccttt cacatgaaca gccttaataa aaaccgccag 10920 gactccccag aaaagcaaat ggttcttcat cttgacttca cttcttctga aaaactggag 10980 caaaaaaagt cagggttaag gtgtgtgatc tataaggagt gtgcaaatga tggtgcttct 11040 gctttcttaa aataacactc caggcagcta acaaactaaa aacaatcaca actgtggttg 11100 aagtctgaag tttaaatgct gaactggaaa aatgtatgac tcacatttaa gtattttctt 11160 gcaaagcatc caaataaaaa ccataatttg atacaatcat ttttattttg catttacact 11220 atataaatgt ttaaaccaga agactaataa taatttcaag gaaggattcc attaagaatg 11280 ttgaaatagg gattttccat tttattacct agatatattc atattagtct tcaaatcaga 11340 catctgacac ttgtcatgcc tagaataata aatgaaggta agtgaaggag gagagatgaa 11400 ggaaggggag agaaatgaaa gtcctttaag gtcccaagtg tatcttatgt taatttttta 11460 tactagtcct taattaacca agctaccaga tttaaatata tattttgtat atatctcaca 11520 aaatatgtat tttgtatata tctcacaaaa tctgtatttt gtatatatct cacaaaatct 11580 gtattttgta tatatctcac aaaatctgta ttttgtatat atctcacaaa atctgtattt 11640 tgtatatatc tcacaaaatc tgtattttgt atatatctca caaaatctgt attttgtata 11700 tatctcacaa aatctgtatt ttgtatatat cttacaaaat atattttgat tactttcagt 11760 tattttataa gctcaaacat ggaattggaa ttagaagctg gtagatactt ggctgggcgc 11820 agtgcctcac acctgtaaac cctgcactct gggaggccga ggcaggtgga tcacttgggg 11880 tcaggaattc aagaccagcc tggccaacat ggtgaaaccc cgtctctact aaaaatacaa 11940 aaatgagctg gacatggtga gggcctgtaa tcccagctat gcgggaggct ggggcaggag 12000 aatcgcttga atcttggatg caagaggctg cagtaagccg agatggcacc actgcactct 12060 agcctgggtg acagagggag actctatctc gaaaaaaaaa aaaaaaaaaa aagaagcggg 12120 tatataccag ataaataagt tgccatattt taatttgata gcattaagac ggaccttctg 12180 tctagttaca cctttcagaa ttgcaaaccc ataagatgat ttttgagatg cctcaaaagc 12240 aaactgaatc actgcagtat tttgtgtaaa atttttttca cttaattaat gtcatttttt 12300 ttaactgagc ttttggacag agcaccccct gcactcccac tccaacatgc tggaatttcc 12360 tgtctcttag gcaaggttgg ttccaagaat atgctggtta cacaacagca tcaaatccgt 12420 gttacttctg gttctcagct ctaatttttg aagggactcc tagaatttta agaggtaatt 12480 aggagtactt cagaatcata agtaaggcaa gcagacttca aagctagaaa tacgaaatga 12540 caggatgaaa gagacattaa aggctagcac atgattgcac ttcttcagag tatgtattga 12600 aagtctgtaa gaacaaagtg tcaggcactg tcatacgcaa tattactata ctgtccaagt 12660 ttattcctat tttaatttct actatcagta ggacttagca actacttgag tttagggaaa 12720 atatactggc atcacatgga cagtttatta aaaaaagaaa cagacctgaa agcacattat 12780 tttagtttgt ggtcaggagg tcaaaacaac tatcaaccac tctaaaagat cctcaccccc 12840 aactgaagtt tctaaataac tgacttattc aatcactcaa aaaaaaatag taattaatag 12900 tcagctggat acctttttaa ttcttgaaaa ataaactcaa ggctagactg ccttcccaaa 12960 gcaagttgag taaatccttg ggaacaaatt aaaacttctc caaaagtttc cttttttata 13020 acagcaaaga ttatttaact cataattact aacctaaaga aaagctctat atttgatatt 13080 ttcattcttc caatcttgct tttttttttt tttttgagat ggagttttgc tcttgttgcc 13140 caggctggag tgcaatggtg ccatctcggc tcactgcaac ctccacctcc caggttcaag 13200 caattctcct gtctcagcct cctgaatagc tgggattata ggcatgtgcc accatgccca 13260 gctagtattg tatctttagt agagacgggg tttctccatg ttgttcacgc tggtctggaa 13320 ctcctaacct caggtaatct gcctgcctcg gcctcccaaa gtactgggat tacaggcgtg 13380 agccactgcg cctggccaat cttgcatttt tatatttcga ttatgtaaac tataaatcta 13440 aaataaattg cgttaataaa aataaagtgt gacacatttg tcattagaag agaattacct 13500 atgctggcaa cataggatct ggactagtgt tttgccttgt gtgctctagg gatcatctga 13560 ctagaaccac ttgtagtact ggttaaaata tggatttctt ggtaacactc agaatttctg 13620 gagatgtgac cttggaatat gtattttcaa aaagcatccc agttgattct gatgtgcact 13680 gaagtttgaa aactaatgga aaaaaagact ggcctagggc aggaagtaag ggagtgcaga 13740 ataactagca gcaataacta tttatggaag aacaaaagat taataaaggt aatttttaaa 13800 taaatagcca tactgaaaag ttagctgaag tttgtatttg cttataattc actataggta 13860 agctgttgca tattcttttt atcattaacc tactatatac aaatacaagt tccagtttaa 13920 tttttaaacc acttctttgc cagttttagt tatgtttttg ccactaaaaa aatgtcaaat 13980 gtgaatagta gaacccttta catgtgtgtt aagtgattga gaacttagcc atgtgttcta 14040 aattctcagc aaaaaaagag gcttattttt ctatactcac atttaagatt tgtgtagtaa 14100 gagattcagt gatagactca gctagatgaa agagatctta aaggtaattt agtctcacct 14160 tcatgactct caattttttt tcaatattct atataaccga attcagcatt tagttgaaaa 14220 tcatccgaaa tagttggatg ctccactccc tgtggacaca actcattata ttttgggata 14280 ttcaaattgt gacaagattt tattctcatg ggacacagag aatgtaactc cctgttttcc 14340 tcctgtctca ctggtgactc cttctgggtc tcttgccaaa ttttcctctg aatattgagg 14400 acatcaaggc ttaatcctca tcttttctat tctcttagcc tctccttaat taattttacc 14460 ttattccatg cctttaaaca tagggcacac tgaggactct caaatgtata actttaactt 14520 ttaccttgcc cattgagttc tgaatgccta tgtccaactt tttattttat atctccatgt 14580 agctatctaa atgggtatct aaacttaacc aggtaaaacg gtattcttga tgaccaatcc 14640 atcctcacac tcacatacca atctctttct gtctcaagtt ttcccccatc tcagtaaatg 14700 acacctccat cagttactca agccaaaatc ctcttctttg cttcctttct tttcctctcc 14760 cctacatcca atttaccagc atgacctgtc ggctttctct ccaaaacata tcccaaattc 14820 atctgattct ctccgttttc actaccaacc tagtccaagc ctccatcctc tttcctggac 14880 taccataata gcttctataa ttaaaaagta acttttcctt tccctcagca ttggtgacta 14940 aggcacacag atcataaaca agaatgacta agtaccacaa atctaaagca agccaaatat 15000 ttcctccaag gtttgttaag aggcaacgaa gccagacaca gtggtgcatg cctgtagtcc 15060 cagctactca ggaggctaag gcaggaggat cgcttgaggc caggaattga aggcaaggct 15120 aaggaagata acagtagttt tcaatgtata actattatgt acacatacaa tttttttcta 15180 aaaagaggca acaaaactca atctacttcc atcaaccacc actccaccgc tcccatacac 15240 tcccatctca tctttagaag actagggagg gaagaggggg gatgttataa gagcagctgt 15300 taccttgttg aaatcatagt gtttgtaata agagactccc acacacatat cccacctcgc 15360 ttcacccttg ggagagtaga gagtaaaggt ggggcacctt cctctcccca gattcaagtg 15420 agggagagtt tcaagaaaat cacccaagag atcagggacc ctaaaagcag gggagattga 15480 gaagcaatat agcataatag ttaagagaaa gggctctgaa cctgactgat tgggtttatc 15540 ccccaattcc accactctct agctaggtaa cactggacaa accttgaaca aatcacttaa 15600 tctctcttaa tttcctctat ctgtaaaagg gggaaataac aatatatgct tcacaggatt 15660 gttgtcaggt taatatttat tacatctatt acatcatgtg aagaagttag atcttggcac 15720 acaataagtg ttatgtaagt actagttact tattattatc atcgtcgtca tcattatgtc 15780 ttaactcctt gtggagttgc agaaaatgca gctaccaact gcaatgaagt ttggggaaag 15840 cattcctggg agaacctgac atggcccctt gggttgtgga tgtgcaggaa tatcaaaaat 15900 gatacatgat catgctatat aaagtataaa tgaaaatgtc caaagtttcc aacttaggat 15960 gggtgaggag gaagttcact tggaagatat gttagcttta tttgtaatag cctaaagctg 16020 gaagcagtct aaatgtccaa aaacaaattg gataaacaaa ttgtggtata tccattactc 16080 aataataaaa atgaataagc tattaataga cacaatatgg atgaatctca aaataattat 16140 tctgagggaa agaagccaga taaaaatttt tttaagaaag tacaggctgg gcacagtggc 16200 tcactcctgt aatcccagca ctttgggagg ccaaactggg cagaacgcaa ggtcaggagt 16260 tcaagaccag cttgaccaac atggtgaaac cttgtctcta ctaaaaatac aaaaattagc 16320 cgggtgtggt ggtgggtgcc tgtaatccca gctacatagg aggcggaggc aggagaatcg 16380 cttgaacccg ggaggcagag tttgcagtga gcgaggtcgc gccattgcac tccagcctgg 16440 gcgacagaac aagactctgt ctcaaaaaaa aaaaaaaaaa aaaaaaaaga agaagtacat 16500 agtgtatgat tctatatttg gatatattta tatttttttc tagaaaattc aaacaaatgc 16560 atagtgacag cagatcagtg attatctggg aaggtgggga cagagagaag ggaaggcggg 16620 actataagtc tataaaagga cataaggaag cttttggaga tgatgaatat gttcattatc 16680 ttagtggtga taatgaattc acaggtgtac acacatgtca aaattgatca aattgtacag 16740 ttcaaatgtg tgcagtgcac tgtatgtcag ttacatctca gtaaagctat taaaaagttc 16800 acatcttcag aattcagttt tttaagtatg atgttaggtt tttcttgggt gccctttacc 16860 aagttgagga agttcccttc tcttcctggt ttgctgtgag tttttatcag aagtgaacat 16920 tgaatatttg tcaaatattt tttctctgtc tattgagata accatatggt tttccttttt 16980 ttgtttaata tggtgaatta catttatttt taaatgttaa actaacctta cattcctaga 17040 ataaacccca cttagttatg atataacatc cttttcataa attttgaatt ttatttacca 17100 aaattttgct tagaatttct gcttttatat tcatgaggga taattgattt aaaatgttct 17160 tttcttgtaa tgtctttgca tggttttgtt actacaataa tgctgtcctg aaaagatgag 17220 tttagaagta tttccccctc tccaattttc tggaggagtc tgtgtagaat tagtattatt 17280 tttccttaaa tgtttggcag aattcctcca gtgaagccat ggcctgggaa ctctctccaa 17340 ggcaacatgg ggcaatggtc tccttatttg tttccagtct ctccgaaatc actgtcctgc 17400 attgcctaat gtcttgaaaa ccagtgtttc ttccgcatgt tctcactcac aggtgggaat 17460 tgaacaatga gaacacttgg acacaggatg gggaatatca cacaccaggg cctgtcatgg 17520 ggtgggggga gtggggaggg atagcattag gagatatacc taatgtaaat gatgagttaa 17580 tgggtgcagc acaccaacat ggcacatgta tacatatgta acaaacctgc atgttgtgca 17640 catgtaccct ggaacttaaa gtataataat aataataata ataaaaagaa aaccagtgtt 17700 tcttaaattt tgtcagtttt ttctagttgg ttcaaatggc agggaaaatc tgcaccgtta 17760 ttccatcttg tttagcattg gagacttgaa attaagagtg agtttgagat acaagctttt 17820 agactgaact agacttttaa aaaatgagct ttactattta tggcactttt acaatcacag 17880 caaataaact agatttttta ataatgaaaa aatattttta aattacggaa tcttcttaaa 17940 acattgtcaa aaaggcaaag aaaaattcaa ttatagtaat tgagaggcaa taattggacg 18000 aaaatatggt ttcatgttat aactcattaa actgttcact gttccaaact cttctctagt 18060 cttacctgcc acaattcatt gtccacttac catgaaaagt gatcttttca aaggtaaatc 18120 agatcatatc tgatttaaaa ccctccagtg gcttctcatt acacttagaa taaattcaga 18180 gtcattagcc ttcctgattt cctgcaactc ccccttccac tcatctctct ccagctactc 18240 tgctcaaggc tttcgtattg tcttagtccc tctgcctgca acactttcca tagccttgca 18300 tggctggccc cttaccacca agtctcaatt ccaatgtcat tgcctcagag agaaattttc 18360 tggctgataa tcttcctaac caattaccaa tcattatcat attgccctgt tttattttct 18420 tcatagtttt tattattgtt tgaaattctt tagtttactt agtcgtaact gtctcctcct 18480 cattaaaata aaagctcctt aagagcggca ttgtcttgtt gcttacttct gtttccaaga 18540 acaagcgcag gattgcctca agtatattga ttgaatgaag gatgaatgga gaacgttttt 18600 acaaggagtt gaaaactgcc tctaagttta tgtcttctaa caatattagt ctcttttgtg 18660 gataggctcc atattgtcaa tgtcctattt aaagagtagt atctagatac atattcaata 18720 gtcaagtgta atctggacag tacaaacaac agctgaactt aacatttttc aataaatccc 18780 acttaagatg ataatatctc ttttttggca gctatgttac actattggct tcaattaaag 18840 tgtacaatct catttttaaa aatatgtttc tataaagtaa tgactttccc atatttaaaa 18900 tttaaacaag ttaggatttg ggcatgagat ttagcattgg tccctaagtt ttatcttgct 18960 aaactcagac caacattaca atgtctcaga ttctttttaa atccagattc agaaaccttg 19020 cacattagtt ctttctctca gctttacagt atctgcaaac ttgacacatg ccatcggatc 19080 cttactgaag tcattaagaa aaatgtttaa tgggatagtg cttaagatag acttttgcag 19140 catacatcta aagtcctatc tctatcaata tcagtccatt aataagcaca ttttgggtgc 19200 agtagttcat ctcaagttaa ctcataatcc atactatcac acagactcaa agtctgggtt 19260 ttatccataa ggtaacatga atacttatca taaaaggcca atctctcctt tattctctat 19320 tttaatgtca tctcatttct ccccttgaaa gccttcccta atataaaagg agtcttgata 19380 gcagcctggc attttgccac ttgaactctt aaaagggacg atgatatttt ttaacaggct 19440 tcttggcctt aaatccaaaa tgcagctgaa atctcttgat tttcctttta atggattaat 19500 ttctacattt agtgtaataa ttcacatttc ccatttgtcc ttgaacttta tatggaaaac 19560 aaattttact aataaatagt actgcttaat cagctctaaa aattaggagg gaaaatatga 19620 agtctacaag aaaccttgaa ttaaatgtca acctgtaaat tccaagtaac ccaaaaatct 19680 tttagattta gaaataactt atcagtgttc ccaaatgtgc tagaaaaaag aaatcctttt 19740 tgtgtgtgtg ataccctaaa tatatctgac agaatcttca gtattattat aagtggtaag 19800 tgaattgaaa gagcatcatc agtcctggat ctccctaaaa agtatcgtct ttcatttcct 19860 tagcactctc atgaatatat tccagaatct atttatttca gaggacataa aaagaaataa 19920 ttttaaaaga atactgtaaa atgtatactc gagataagca ttttatatct gacaaattta 19980 caaagtctat tacagaggaa ctccatgact acttttacaa ccaggtatat ataacaatcc 20040 cagaaaccca gaattaaatg acacacttgc aaggaataca gagaggaaag taagatattt 20100 atttccctaa aacatagatt ctaaaatatg tcaaatggcc attgaaagca cagcctttaa 20160 ctcttctccg tgtataccat ctctctaact tctatacgtt tgagacacta gacaatacaa 20220 aagtaacttt tgaatcaatc cagagaaata aactgaagga agattctatt agcactgaac 20280 gaaagatctg ctgccaagag aagctaacag caaaaaccat ctccactcca tcaaaaacca 20340 tctccactcc aacaaagtgg aaaattcatt atatgtgtgt gtatatatac ttatcatgaa 20400 tatataactg ctattaactt aatactacaa aactaaaagt ccccaaatat cccagaattt 20460 cacaaatcag tcaagcataa aattactaac aaaggataaa gaggaagatg ttttttgtgt 20520 tgtgtgtttt ttgttttttt tttttttgag atggagtctc attctgctgc ccagactgga 20580 gtgcagtggc gcaaccttgg ctcactgcaa cctccgtctc ccaggttcag gcaattcttg 20640 tgcctcagcc ccccgagtag ctgggactac agacatgcac cgccacgcct ggctaatttt 20700 tgtattttta gtagagacgg ggttttacca tgttggccag gctgatcttg aactcctgac 20760 ctcaagtgat ccaccggcct cagcctccca aagtgctggg attacagatg agagccaccg 20820 cgcccagcct ggttgtttta ctatgacaaa actgaggtat agcccttgat ctgacaatcg 20880 gtcctcctac caagatcctt gctgggttgc tctgaacttc ctaaaactcc tatagggcac 20940 tctgtgtcca aatccacaag agcacacatg acttatctgg aataattatc aataaaagtt 21000 ttaaaatatg tttaataata ttaaggagta cagaagcaat tgcaactata tttgcaatgt 21060 ttgggaggga cattattctg cctaacctag agtcaggcaa acactattcc aagaaaggaa 21120 acaacaagta aaaagcacaa aataagaaag agcttggccc acacaggatg aggagcagga 21180 aggaaggcac ttgtagctgc agcagagtga gggggagaat catagtagat aacaacacca 21240 tgcactttat aggattaact tttttccccc attttttttt tttttagatg gagtctctct 21300 ctgtcaccca ggatggagtg cagtgacatg atctcggctt accgcaacct ccgcttcctg 21360 ggttcaagcg attatcctgc ctcagcctcc tcaggagctg gaactacagg cataaaccac 21420 cacacctggc taattttcgt ctttttcagt agaggtgggg tttcaccatg ttggccaggc 21480 tcatctcaaa ctcctgacct caagtgatct acccaccttg gcctcccaaa gtgctgggat 21540 tacaggcgtg agccaccatt cctggccttt tcccccattt caattgtaca agcttagaat 21600 ctattttgaa cttcagaatc aatcttagtc attctaaagc taaaggtaga gagcctaagc 21660 ctcttaactt acagtccatt ttacctctca caataccaag agccattaat actatttttt 21720 cacatctata tggagaaatt tcttctaatt ggcatttttt gggggtgggg gaattgaaag 21780 attagactga atcatttcac aatgtgatgt tttgattatg tataccttgt gaaatgatac 21840 aaaacttaga aatctgtaat ttaaataagt gaaataatca aaaatgattt tgtctaacaa 21900 aaatgcttta gctggctgaa cacggtggct catgcctgta atcccagaac ttcaggaggc 21960 tgaggttgat gaatcacctg aggtcagaag tttgagacca gcccagccaa cgtagtaaaa 22020 ccccagctct actaaaaata caaaaattag ctgggtgtgg tgaagtacat ctgtagtccc 22080 agctacttgg gaggctgagg caggagaatc acttgaaccc aggaggaggc tgcagtgacc 22140 caagatcaca ccgctgcact ccagccttgg caacaaagca agactctgtc tcaaaaaaat 22200 atatatatat ttagctattt ttgcagagat atacactgaa tgattttttc tgatattata 22260 taagcattga atgattaaaa gtcaaacaga gcatttttac tcaactttga taccctttga 22320 taccctcctt cctaatcttt gtgacttcca acctcattaa atgtctgata atactaactg 22380 ccatttttta accctaaaca ttttcgttct tatatgcaga gtttcttcaa atattgatct 22440 ctatccaagc acagtgtatg taaaatttat atttagatat caggaggcaa aagctggtca 22500 gttgggtgca gtggctcacg cctgtaatcc caacactttg ggaggccaag gcaagcagat 22560 catttggggt caggagttaa agaccagcct ggccaacatg gtgaaacccc atctctacta 22620 aaaatacaaa aattagctgg gaatgatggc gcatgcctgt aatcccagat actcgggagc 22680 tgaggcagga gaattgcttg aacctgggat acagaggttg cagtgagcca agatcatgcc 22740 actgcactcc agcctgggcg acagagtgag actccatttc aaaaaaaaaa acagaggcaa 22800 aagctgaatt taaaaaaaaa aaccctcaaa atatgaagaa gaaacttcat tccaaattct 22860 tactaaaaat taaaaaatac aaaccaaaaa attgacttct ttttctcgaa cagctttcca 22920 catagacttt tagggtagtc cttctgtggt taaatgttta tgaggagaat tgcacctgtg 22980 ttgtggtcag cttttaaata aacttgcacc tgcagtggtt tttcatagaa ttgctgtttg 23040 agaaattaca tgtcagtggt ttgaccatca cacagagcta tttcccttca ccatatcacc 23100 tgccaggcag gtcctaattt aaaaagggcc tacttccaaa aattcatttg aaaaaaaatc 23160 tggttagatt tcatggtaat ctctccaggg acacaataat aagtaaggtt tccaggatac 23220 ccctcaaaca aaaagaatat gctcccttca attcatccat tgcagtggtc tggtccttct 23280 ctgctttaag aaaacttctg atttctggag aggcttctgc tctagtcaat tatgtctgct 23340 ttccttttcc tgtatattat ctgctaattc ctgtttcaga atctttttta gtttgtcatt 23400 ttccttacca taaatttatt tctctttcct tcctgttcat cctcataaaa aaccctaaaa 23460 tctttcaaac taattcaagt aggtctaaat gtcattccat tctgttcact cttttacttt 23520 gtttcttcat tgctaataaa ttcatcttgt atcttgtata ccattttact cagctggcat 23580 attactttat cacttttctt catatgtgtg taattttata tattaatgtt ttctagatgc 23640 agagaggtgt tcataaagag caatatcaga tggcacccca aaaaaggata tgaaagaaca 23700 ccaaaaggga actctaaaga tttagttgga aaagtaggta agaaaataca attttcttgt 23760 tctaactctt ctattcagag tgtttacatc atatgtaagt gccatactaa gttcattttc 23820 cctaataacg agaaagcata aatctgtggt gaggaatatc cagtcagtta tttttaaaat 23880 atcagatgca actgtaaaga tgtgtcttaa gagacacttc tacttagtct tcctactgaa 23940 caaaagagca aacgctgtgg agtcagttat tgcctgggtg caaatgggac tctgacaagt 24000 tataaaatct tgttttctct gtttcatcta taaaatgggc atcactgtag tacatacttc 24060 acaagattga tgaaaattaa attgataagt gtaaagcatg gaatatgcta gaacatggct 24120 acaacatata aacaattact ttagcataat gcttagctct tgatctgcct acttttcata 24180 tccatattcc caggaccctg atttagacac aaaaacgcat cactctgatg actatcacca 24240 tcttgcacca acttccttct gtcaattttc caatccttcc ctgtttaaaa ccctccaatg 24300 attccccttt gctcatagca taaataatat atctctaccc aaaatagata tagatcaaga 24360 tcacatttgc aaatagctta ttaaattctt aggtcatttt taataatttc taatacctta 24420 ttgaaattta acagagcttg gttttttttt tttttttttt ttttgagaca gagtctcact 24480 ctgttgccca ggctggagtg cagtggtgca atcttggctc actgcaacct ccgcctccca 24540 ggttcaaatg attctcctgc ctcagcctcc tgagtagcta ggagtacagg tctgggccac 24600 cacacccagc taatttttgt atttttagta gagatggggt ttcaccatgt gggccaggct 24660 gctctcgaat tcctggcctc aaacaatgca cctgcctcgg cctcccaaag tgctgggatt 24720 acaggcatga gtcactgcgc ccagccaatc caagcctttt taatttgaca cctggagata 24780 tgtagtccta taactctagt agcaggtagg tagtataaca cttttggtct actagttcac 24840 gtgtgctagt tacttaagtc agaacaaccc aaaattatat tttatttgcc tttagttaaa 24900 tatcaaatat ggtcccacgt ttcaactgaa ttttaaagac atcaaaaatt tctttctcta 24960 aagagatcca tatatcaaac catctagaag acatctagac acttaaatag cttcacagac 25020 acctcaaatc aaacatatac aaaacttaac ttcccatttc ttggcccctg cttaaatctt 25080 tttttttttt tttttttttt gagatggagt ctcgctctgt cgcccaggct ggagtgcagt 25140 ggcgtgatcg cagctcactg caacctctgc ctcttggatt caagcaattc tcctgtctca 25200 gcctcccaag tagctgggac tacaggcatg caccaccaca ccaggctaat ttttgtaact 25260 cctggcctcc aacaatccac ccacctcggc ctccaaagtg ctgggattac aggcatgagc 25320 caccacgccc ggccaagaca agtacataac tagtcttaac acaaaggaga aaatgtttag 25380 aaatccctaa gaaaggaaga gttagggact attagatgtt aatagaatga agtatatcag 25440 agaagacagc ctagagaaga cacaatctta gctgggcctt gaaggccata taagcattga 25500 aatatgagac agcccaaaga gaggccaaga gaataaaaat ctcaaaaaga gaaaaaaaaa 25560 tgagtacata gtttggctag aacatataat tcatgaaagt gggaaagcag ctggaaaaat 25620 aagttggggc cagataaagg caggccctga atattggctt agagataaga acttgattct 25680 atagagaatg aggggtgact aaagaaaaaa ttttaacatg ggctgtgttt caaaagacct 25740 tcaccaccaa agctataatt atcactgggt caatatttaa atcaaaataa ttgtagttac 25800 aagttttccc atgaaaagaa aaaactaaaa gggattaaat aatgtttaga aagtaattgc 25860 caagttttta gttgaattag agtttggaag ggaaagcagt gtcgtaattt cactaaattc 25920 ttcattttgt aatgaaggct accaaacctg ttttctagat gcagagaggt gttcataaag 25980 agcaatatca gatggcaccc caaaaaagga tatgaaagaa caccaaaagg gaactctaaa 26040 gatttagttg gaaaagtagg taagaaaata caattttctt gttctaactc ttctattcag 26100 agtgtttaca tcatatgtaa gtgccatact aagttcattt tccctaataa ggagaaagca 26160 taaatctgtg gtgaggaaca tccagtcagt tattttaaat taagttaaat taaagattaa 26220 aagcttcaaa tatttaccaa atatttcagt agaagctcta tattttactt ccaagtc 26277 <210> 31 <211> 122218 <212> DNA <213> homo sapiens <400> 31 tttgccaagg tatatacacg tttatttaaa aaagtttaca gttttcatta tacacaacta 60 ttaagaggtt atagtcagag gaggcatgtg tcctgttgac agacgtgcct actagatcat 120 cacaatgcaa ggagaaaggt ggaagggagg agacagggcg aggaaaaata agcgataaaa 180 agcttcagat ttcagttagg ggctggcagt cccttttatc ttttcaagta tcacacaata 240 tgtaccaaat acaatctgta aataatggcc atttcttccc aagcccacag ccaagatgag 300 tgttaggcta aattcagagc cctggctctt cctcagatga gtggaaaacc tgcgcatgac 360 agggccggct cccccttctc aaagggcttc ctcccactca tcccatccct aacagaatcg 420 ccgaggtgtt cacgggccag agaaagcaca aacatggatt cagaagtcca aagaaatgca 480 gttcgttgcg cccaatcaga gatagatgat ttcattcaac aaggctggaa gcccagttgg 540 gaagtcgata aaaaatcttg ctaacttttt taaatggctt ttacttttct aagtcactga 600 aacaaggaag ggccacatgc catttaaaat caaacactag ttcccagaga cttggtgtcc 660 agaaacttga cccacagagg ctagcggagg atctgtcttt catgattctc agccatccca 720 acgggaggcc taacataaag catgtgccag gccaatgcca actaggactt cagggggcct 780 ttggagggaa aaattccttt gagaggagac attcctcagg agcttagatc agccagctgg 840 cagtcagaac agcttttgaa gtggatgaga aatgttaggt actggagaga tgatatggca 900 actcctgata atgacctcac taggataaaa tgctggttga aactgcacag taacctcaag 960 gagggtgatg aaattgacga caaagccaaa tgtcagtgtc taagatggct accactgacc 1020 ctgtgcccaa aagccccccg gtgctggggc ttccagaggg agcccaaggg tggtggattc 1080 aatgttgcca ggttgcaacc atcttgcttg ttggtgtttg gcaagagctt gagctcagtt 1140 atgtgaacag gggcaaagaa tggcttgtgc tggtaaaact caagggagga tccaaaaact 1200 atgggcacta aaaaggggag ggaaaccgcc agaagtggct ctgacctgct gccgctgcca 1260 ccacctctaa agccaagaat gtagagcctc tgcccaggga tctggatgct ctcctgagtg 1320 ttggaagggc agcctggaaa ggcatttggt ggtgaaacac cgctgctcca gacttacgct 1380 accatctatt gttgggggcc cagagtcctt ggattcactg ccaggccttc ttccagatct 1440 ttctgtacct gtgtgtttgg gctcctactc ccacctctcc caggcgcagg gagaggacaa 1500 aaagcataag ggactctgtt caacccagca aaagtcagtt tcccagtgga gaggcaaagc 1560 cccacccaga acataaacat gcatgggacc aaggttagtg cccagacagg acagacttgc 1620 acagaacaag agggcacagt gggatccatg cggcaattac aggagcttcc agcactaaca 1680 gaggagcctt atcccacctt catcacacac acttagatgg acacacacac actctcgctc 1740 acactctcac acatgtgcac acatacacac actctctctc tctgcagcca cactcaaatc 1800 tgctaaactc ctacaacctc ccccagcagg tcatttgaca attctgcatc ttccgctctc 1860 tggtgctggg gctctggtca gaggcgagcc aatgtcttat cattagagag atgtgggatt 1920 aggtaagggg cagagtcatg gcactgctca cacaccttcc cgaaactggg gtctattcag 1980 ttttttgaca agatcaaaag caattcttaa ctggtcatta ttttttttta aggtaattag 2040 aacactattg tttatacaat attgaaaaaa tacaattttt tattgtttga actcaaatca 2100 ccacccagca ctttaagcct accctaaata gcacctacaa taaatgtcat agcacaagca 2160 aactgcaaag tcagcaggta agcaagttag acagtgccag cagagagacc ctccctcccc 2220 caaagcaatg agaagacagc gtgctaggta agagtgaagt acaccattac atgttaaata 2280 gttaatacta cccttccagc aagccacaga tgctagatgg ataactcagt acggttaact 2340 aaccacagcc ctacatcact gcactttttt ttttttttaa agaaaacctt ttgcttcatg 2400 cccgtaatta acataaagta agtaaattct ttgtcttttt atttaggaaa ataatcatgc 2460 taaaagcaag ttgtacttta tatagatttt caaacaaaag attgattgtg ctttttgaat 2520 aaaaaagata gggtatcttc caacctcact gacttaaacc ttgtggaata cagcacttct 2580 aaactaaaaa cacacgtcaa aaagaaaaat taaataatcc cagtgggatg ctcaaaaatc 2640 gtctttagaa ggttttagga ttggctaatt ctgctattat cttattggct gcggcaaaaa 2700 aagaacacag agctgctgtc taaaatttct ccaaactccc ctccgagttc agcaggcaac 2760 actcagattt gaaagaaact ctgcagcaac ctggacatat ggttagctga gtcgacattt 2820 gattagcagg cattttaaac tgatttcctc ttaacatacg caggagagaa aacattttct 2880 tcctgcaggg catgttctac tacatcatat ttctgaatcc cttcttccta ttcggtcact 2940 ctctgaaaaa agctggtttg tttttcccat gtagaatcac tctgggtaca agaaccttta 3000 tttgttccaa ttattatttg ttttaaattt agaacctgtg ttgggtctaa aatacccatt 3060 tcccactccc acaagcagat gatgaccagg ctgctgccaa gagcagcaga aaaagggaaa 3120 accaaaccag aacatgaagg caagtaccca gggctttgca gtcaccacgt gggtcgtctt 3180 ctcaagtcta atggtccatg agcggcttgt ccaaggaggc ggccgcctct tggtaggtga 3240 agatgaaatc tgcaaccttt ctaagcacaa tacacacaca cacacaccaa aaaaataacc 3300 cccccagaaa cacaaccctc atatttaaag ctcttaagtt cagggtagcg gtctcaaact 3360 gccaaacact aggatgagga tgtgactctg catgtgtttt ggatgagagg aagcatcgtc 3420 ccagtcactt ttctcctcct gtgctgtcct ttcaaaaaca ggtctggatt tcacgctcta 3480 ccccaagaaa aagaactggt tcagaaaaca cttccccaag tttctccaac agaacactgt 3540 ggctgcaggg cctggtagtg tgaagggcag caactgacat ataaaaatgt acttaaaatc 3600 agagtcaaaa aatggtttta agttttaata ctcttaatta gctccctgct ttatactgta 3660 actccacaga agacataggg ccacctagga ttcacaggaa ggagcagctc tgattcttac 3720 atggctggct ccgatgcccc cacagcaggc ctcttcctcc ccaagttttt cctctccatt 3780 tcaaaaaagc actattttat cttcacatcc aagagctggt tggtttggtt tgtttctttg 3840 gaaaccaata aaagaagcaa ttttttcctg ttctttttac tcacatctac ctatcagagc 3900 ggctatttcc ttcgacagtt cagtagcaca caggctgact tggccacatg gactcatgaa 3960 tgcatgcatt cagaccgcat attgctacca aatggaatgt gggaatatgc tatgcacctc 4020 aggttgagaa atgaccaaga aatcaagatc taaagggtga tatataatat atatatatca 4080 atgctattat tcataaaaac cttgtttagt aataaaaaaa attgctttgt ttaaatatga 4140 atattatagt ctgcttctca tggttaggaa ataatagtct ttctgaaaag caggtgcttt 4200 ttctactaca actccatatc ctgggcctca tcttcggaaa agtcagacat agagctctcc 4260 gatgagctgt ccccggtacc ctcttcctgt tctttcagcg cctcctccgt ggcgtatttc 4320 tggatgtact ctgcacgggg tgggagaaag acaacaaggg cagtgagtgg gcaggcatgt 4380 gctttggcga ccccaaaaag ctggcaaggc tgcggaggtt caaacttacc ttgaacacca 4440 ggggggacaa agatgacagt aatcatgatc actacagcta aggagaatcc catagggaga 4500 cttctttggg acagggtttc tgcattttgc cccctgagga aaggggtatt gggaagagca 4560 acacagcagg ctcagcttgc aggggaatgt gtgtgctgca gcaccccaag aactcttcag 4620 ggaccaggga aatgggagcc ccacgctttc tttttacttt catctcccag atagtatagg 4680 accagtcatg attccatagt aatttataag gaaatccttc atcattttta gatctgcagt 4740 tacataatta cggtcagtcc aggtctatta ttttaggaat cgattttagt ctaaacagat 4800 cctgcctgtc aggtttttga agcagctggc aaaaaccatc gctcaatctg ctcaggacta 4860 agctgctata cggagacacc actcggctct gagtggtttt tccatgtata atttacctga 4920 aggtagattt ccgctgctac agccttggtg gaaccctagg ctgaataaga ctgctgaaac 4980 ggcttttaag aactgctgaa taaacaaact tgttcctaaa aactctaagt gcatactgtt 5040 ttcaagtgaa cagcctccac acaataggaa aagacatgac agaaacctat tcaaaatgca 5100 agccacacaa aaacacaccc ttgtggcttt gtttttcctc ctatagagtt gcggggactc 5160 actgcaatag gaagataagc tgaatggcca aatgggccta ccagatttga ataactagca 5220 cagggcctag ctaagaatgt ttttatattt taaaaactgt cttaaaaaat aataaacaga 5280 atgtgtgata aaggccacat ctggccaatg tggtccttta cagaaaaggt ttgcagactt 5340 gagacttaga gcccttcaaa ttcattataa caaaatttta tgctaatgat tttgatgaga 5400 ttaaagtagc ccatgattag gtaggaattt accttaattg agaaatattt attcaaactt 5460 taacaatttt atttttaacc tctaatgggt tgactatttt gcgtcttcct ttgtagaaga 5520 taaatattga cctttttttg acactagaat ttgatactat cagccctctt taatgtattc 5580 aaggaaacaa atgtatatta agtacttact aggacaaggc ctttgagaga gagaaaggaa 5640 gagcaaggtc accaatgagg aggaggaaac agaggaagat aaaaggagct gctgagtgtc 5700 accagaggga agcagttacg gacgaaaaac ggccgaggca gtcccagcca cactgacccc 5760 caagtcctgc cagctatggc ataggagagg ccactccagg gaaaggcttt gttttgttga 5820 aagtaagtgg ctgggatgtt taaacacaac cttaagagag aactatggcc aggtgcagcg 5880 gctcatgcct gtaaacccag cactttggga ggccaaggcg ggtatatcac ctgaggttag 5940 gacttcgaga ccagcctggc caacatggtg aaaccccatc tctacaaaaa tacaaaaaac 6000 tagctggatg tggtggcaca tgcctgtaat cccagctact cgggaggctg aggaaggaga 6060 atcacttgaa cccgggaggc agaggctgca gtgggccgag atcgcaccac tgcactccag 6120 cctaggcgac agggcaagac tccgtctcaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa 6180 ggagtaaggg caaagatgta gattccactc agtatcagag agccctgaat ggcaggcaaa 6240 gatgtcaccc agcaaagggt tttgagcagg gaagtgacag ctttagacag ctccaatggt 6300 gcccagtgct acgggctatc caatatttaa acactttttc aaacatgtac tataatacag 6360 cgccaactaa atatgaacac tgactgtgtt agctgtgttg ggttggtggt gactgccaca 6420 caaatggaaa tgtccagcag cagcttggga gagaggccag gcctagacac acattcagaa 6480 atcatctccc tggaggggac tgactgaagc tgtgagaggt gaaacagctc ctcagggatg 6540 acaaaggaag agagggagcc cagggaccga gtcctaagtg aatgaccaca tttaggaaat 6600 ggaatgagaa gtttccagaa agatgagggt aaaatgtaac acttgcagaa aggtccagca 6660 aaatgggact tgagaagagt ccaaaggatt gggaagaaat gagggcacag attaagcaga 6720 ggaggggaaa aaaactagag gagtttaagg tgaggacgca agaagtttga aaatgaaaag 6780 gaataaacag catgactcct aagagagccc acaggagcag atcactgctc ctgaaacagg 6840 gagacctctg atggggtgga ggaggaagac tgcattggga gggggcgggg ggttggggga 6900 acaagatcac agattggtgg tgggagtgag tttgagaaat gaggaagggt gtctcttatt 6960 tatttcctat agttaggaac aaagaaaaga tgcaggaggg aagggagaag atatcaaggc 7020 acagtaggaa gtgggggtga gctcaggtct gatggccatg attttctgag attactaagg 7080 aagacaaaat gatagccaac atgaacattt ccgaaggcta ggggtccgta cgctggagtg 7140 agccattcta agataaatgt aggctcggtt ctttttgtaa atgggactat agcagacatg 7200 tactgaaaca gggctactgc taaattgttg agacagaatg catatgtgaa ctagagaaat 7260 atactctgct ccaagatatc tgtggtttgc agacattgct aagtgattcc tatgtcaaaa 7320 ttttaatata gtctcataac agcactttat ctggctgaaa ctgactgcct ttttcttcaa 7380 atacatgttt gcttagctat atattttgct acataaatta gatattaatt tgcaaagcac 7440 ttgagatcta attaattata gtaaatttat ttctgcttta tctcaacaac agctccaaac 7500 aataccctat agagaccttg gaagaagaat tagaaaacaa atagaagaaa agctattgtt 7560 tcatgaatag tccctgtttg cctcatacct gcacatttca gagtgaagac ctgcacattc 7620 aagctctggt aaattacttc tactgccacc tcttgcaaat gtacctcaga gaggccacac 7680 attttgagga agcaaacatt ctggactgct atgcagatag gcccatcatg tgaaaaactg 7740 gctagatact aatgcctgcc attggttaaa agcagcaggt atatttcaca aactttgaat 7800 tcctttgctt cttggtggag cttcatgtat ctagactttt cactatgaaa gttctgaaac 7860 atacacagag gtaaaatgga aaatccaatg aacccaggtg gagctttaga ttttttttct 7920 tttttaaaga cagaatcttg ctctgtcacc caggctggag tacaatggca cagtctaggc 7980 tcactgcaac ctctgcttcc tggttcaggc gattctcttg cctcagcctc ccgagtagct 8040 gggactacag gcgcgtgcca ccacaccagg ctaatttttg tatttttagt agagatgggg 8100 tttcaccatg ttggccaggc tggtctcgat ctcctgacct tgtgatccgc ctgcctcggg 8160 ctaccaaagt gctgggatta caggcgtgag ccaccacggc cagtcgcaaa cttatcttca 8220 tttaaatgaa actcatatcc catcagcacg taaactgttt taaggatggg aaaataggat 8280 tctaaatcgc aaaggatgag caaactggtg ctactgccac ccgaggttgg tgagcactac 8340 ttcagcccac agctgtctct ttttaggcct aagaaaaagt attaggaact aagtaattta 8400 agaaggactt ttaatgactg aagcccaaca gatttaagtt cttttgtctc caggttaaac 8460 tacccatcct cttaccttta attttctgct tgtattcttc tggtcggtgg aggtacatgg 8520 ctgcagcgtc accattgaga ggatctatgg ggttaggata ggccaataac tgaggcagga 8580 aggactcaaa tatattggta agatctgaaa aaccaaacaa acatgtcaca catgggaaat 8640 gcaagttcac ctaaaattca cttgcattca gtagtcaagc tgcttacctt cttagatatt 8700 cacacgggga tgattctcca tacgagtgtg ctctattaca tgtgacttgt attacacatt 8760 catttcaata ccaatttaaa cattttaatt ttaatttgaa gaacgagata aagatatacc 8820 tgacattcac tttgaaggac aattttccca attctatttc actctattta tatggctatt 8880 tcacacagcc attttctaca gcttacaaaa ccccccactc tgaaaggtat tcagatgctg 8940 ggtcttaaaa gaattgaaga cagtttttgt ggggtttttt tgtttgtttt tttttttgag 9000 acagagtctt gctctattgc ccaggctgga gtgcagtggt gcaatcctga ctcactgaaa 9060 cctctgcctc catgttcaag cgattctcct gcctcagcct cccaagtagc tggcactaca 9120 ggcacctgcc accatgcctg gctaattttt gtatttttag tagagacggg gtttcaccat 9180 gttggtcagg atggtctcaa actcctaacc tcaagtgacc tgccagcctt ggccttccaa 9240 agtgctggga ttacaggtgt gaaccactgc gctcagcctt gaacacaatt ttataggact 9300 tgacatttaa ttcaattctt gcaacttcta atggaggtaa atataaccaa tttttcaatt 9360 attctgggta atgaggatag gaatctatat ggaccacata agactacaaa tattcataag 9420 acagataagc accaatctac tgcatttatt tatttaaaaa agtttttttt ttgagagagg 9480 atctcactct gttgcccaag ttggagtgca taggtgtgat catacctcac tgcaacttca 9540 aactcttggg ctcaagccaa cctcccagcc tcagtcttcc aagtaaattg gactataggc 9600 atgtgccacc atacccagct aatttttttt tttttaaata gagacagggt ctccttatgc 9660 tgcccaggct ggtcttgaac tcctggactc aagagatcct tccatcttgg cctccccaag 9720 tgctgggatt atagacgtga catttattaa ctcctttctt gccaggcata cacagatgat 9780 atctacacac agttagcaaa caacaaacac ctgcagttac ccagcgtttt agaaaagcag 9840 gccctgagaa cctgggtata acacaaccca cacaccccat agctcagata tgctgtaact 9900 tccacactct gctcctcagt gaactgcagc acccctgaga aatggaagga catgagaatg 9960 cttccatgtc tctgccccac tccagctgct ttgtcatgtt ttatataaaa cattcctgtt 10020 tctggagaca atgctgaagt atactaagta gcataaaaaa ctactcatta atttagtcag 10080 ctctttcaac caattttgct tttaacaatg ggcgctcctt tgcagtatta cagatgaatg 10140 ctttgccaag ccacattgct tgagatttgt ggttctcagc caagggtgat tttgctcccc 10200 atggaatttg gcaatgtcta gagacatttt tggttgtcat atctaagcgg tgctactggc 10260 atccggtggg tgaaggccag ggaagctgct aaacaccaca atgcacagga cagccccaca 10320 acaaaggatt atctagacca aaatgtcagc agtgctgagg ttaagaaacc ctgatctaga 10380 taaaagcggt aggcaaacct ttttgtaaag ggtcaaatac ttttaggctt tgcaggccac 10440 atatggtctc tgtcataact actcaaaact cagctctgcc actgtaacac aaaagcagcc 10500 aaagtatagg tcaacaaatc gatgtggctg tattcctata aaactacata tacaaaaaca 10560 agtacccaag gtctgcccaa ctttgctcta gaaaatctta cctataagag gtggctctta 10620 tcactgtaag gttaagaagc tgagcagtta gagactaatc tagagctgtg ttactcaacc 10680 gaactttctg cagtgataaa aatgttttat atgtgctcac ctaaaccaat agccactagc 10740 cataagtggc tactgagcac tcaaaatatg gccagtgtga ataaggaaat taattttcag 10800 tttatttaat tctaattaaa tttaaataac cacacatggc tagtagatcc tgtattggac 10860 agtgcaggtc tagagaatga tgggctagag ggtcccatga cagctaccac gtcctgttct 10920 cacacaccag gtattgacac agagcagctc tgccttacaa caaaagccac agacttgggg 10980 tgatttcatc agagtctatt tcaccttcat aaggctgact tcagaacggt cctaaagagc 11040 cactttatag taaggttctc atgtaccacg aaagaaatcc tgacactcct aatcaaaaaa 11100 gcaaaacaaa aatcaccttc ctatataacc cccaaactat ctgcagtaag attttcacca 11160 atgttttatc tacaattttt ttaaaaaggg aaacaattat tatggtacaa aaccattgaa 11220 aactatttgt tttcaatgaa aaaaatgctt atacttgaat gctgggtaga gaaaggccat 11280 aaaatggtat gttttctaga attacaacta tgtacagtgt gtatgcataa gacaaacatt 11340 ttaaaaagct acctcaaggc aatagatgtg taacttctac ttttcacatt tcaaatgaca 11400 tttcttttgc ctttaaaaat caacattttt ggctcacacc tgtaatccca gcactttggt 11460 aggccaaggt gggtggatca cataaggcca ggagttcgag accagcctgg ccaacatggc 11520 aaaaccctgt ccctactaaa aaatacaaaa aattagctgg gtgtgatggc gcgtgcctgt 11580 agtcccagct acttgggagg ctgaggcaga attgcttgaa cctggggagg tggaggttgc 11640 agtgagccaa gattgcacca cagtactcca gcctgggcaa gtgagtggaa ccctgtctca 11700 aataaataaa taaaataaaa ataacatttt cctgtaaata tgtcctttct attttggcat 11760 atgtttgaaa tatccaataa aacatgaaaa gtctgaaaat gtttttattt tcttatcttt 11820 atccttgggt gggtgagtta ttaaggcagt ggtagaaaat gccaaaaggt aagcaaattc 11880 agttttacag gccagacgca gtggcttaca actgtaatcc caacactttg ggaggctgag 11940 atgggcagat cacctgaggt caggagtttg agaccagctt ggccaacacg gtgaaatccc 12000 gtttctacta aaaatacaaa aattagctgg gtgtggtggc aggtgcctgt aatcccagct 12060 acttgggagg ctgaggcagg agaattgctt gaacccagga ggtggagttt gcagtgagcc 12120 cagactgcgc cattgcaccg cagcctgtgc aacaagagca aaactctatc tcaaaaaaac 12180 aaaaataaaa acaaaaaaca gtagttttac aattgaatgt gatcccatag cagggaaaag 12240 ttaaacaata gttacattaa cagtaatttt tttttttttt tttttttgag acagagtctt 12300 gctgtcaacc aggctggggt gcagtagtgt gatctccact cactgcaagc tccgcctcct 12360 gggttcacgc cattctcctg cctcagtctc cccagcagct aggactacag gcacacgccg 12420 ccacatccag ctaatttttt tgtattttta gcagagaagg ggtttcaccg tgttagccag 12480 gatggtctcg atctcctgac ctcgtgatct gcccgcctcg gcctcccaaa gtgctggaat 12540 tacaggagtg agccactgcg cccggcccat taacagtaat attaacagta atggcaggtt 12600 aatgcttaca tagtgcttac tacaagcaag gaactcttcc atggtctgca tatacactct 12660 taatttcact acagtcaatg aggtaggcac cattttacag atggagaaat tgaggcacac 12720 agagcttaag tatggatcag gaactcaaac ctgagctcat ccactatgct gcctctgtta 12780 atggataaaa cacacactgc cgctgccgca aatttcacga aggcacaagc tccccatgtc 12840 tctgggtcaa aatcgcatac catcgctggc agggaagcta aatccatgga tcagagatga 12900 tcaccctcct ccccaaagaa tccctcacaa gtgcaaagaa gcatgctaag caaaggacgt 12960 tcagatgttt ctgtggctat tcacagagac ggtgtgcttg ttttcatgca gctccaccgc 13020 aggaggtaac ccgcagacac ctgcacacag cgaacggaag gctcctcctg ccatattatt 13080 attacaggtg ctgctcaaaa ggattagcag ctggatgcta ttacataaca acgaaaacct 13140 ttaaaaacaa agcataggtt ttatgttctg aagtaatgtt cagaagtgct tcagggctag 13200 agaaatatca cagacaacgt gttataaaac taggagttta gcgtgtccca gaaagagatt 13260 ttataccctt tcctactact tttaagtttc ctcaagctac caataaaagg ctttgcctat 13320 gaatttgttc caaacaaata aaagaaccct taattattgg ttcttccttc ctgtatctac 13380 cgtcttcctg cattaacaca tttttgatcc attttacaga agtgctgagt cacacctgta 13440 aaacagaaga gcagaaaagg aaacacatga ggcccagttt tgggtgaaga tgacaacttc 13500 gggaggccag gatgtgatgg ctctgccatc ttaaagcaat aaggccttcc tgcaagtggc 13560 taacacagtg attactccta agggtgcttc tgaaaggagc atctctcaaa tgtgcagatg 13620 tgcagaaagt cttctttcaa gataaataca ctggcagaga agactaaaac tataaatcaa 13680 gaataaaata aagatactca tctgtagaaa aataaagaac actttttccc tagatttttg 13740 ttaatgataa aacgataaaa atgtgtcgat aataataacg ataaaaatgt gtcagttcaa 13800 agatctttat ctaaaaacat taaccttcaa tttttttaaa ggaagagagc cagatacagt 13860 tgacctaaac ctgtagagta cagtcagccg accccatttc cgcctgtctt aacttttaaa 13920 ggaagtccca agattcctga gtatatggtt tatgatgagc aaacagctct tacttttgcc 13980 ttagactcaa ttagaaccaa aatgtggttc attagcactg actcttcagt ctgatcttac 14040 attaatgtta aaattataac actcatatct cagtttaggc atataattta tattcatatt 14100 tactatttaa aaacaggctg ggcacagtgg ctcatgcctg taatcctagc actttgggag 14160 gccgaggcag gtggactgcc tgaggtcagg agtttcacac cagcctggcc aacgtggcaa 14220 aaccctgtct ctactaaaaa tacaaaaaat tagccaggcg tggtggtggg cacctgtaat 14280 cccagctact tgggaggctg aggcaggaga attgcttgaa cctgggaggc agaggttgta 14340 gtgagctgag attgtaccac tgcactccag cctgggcaat ggagtgagac tcccaaatca 14400 taaacaactt atcatcaaaa gtagcatcac ttagtctaga gcagtggttc tgggctaagt 14460 ctaggtcctg cttgtccatc acaattacct gtggagtttt tccaaaaact tgcttagcat 14520 cctaaggttg cagcttcata cctaccccag ggcttctggt ttaggactgg atgggatctg 14580 tatgtgtgtg atacagacat ctgtgtgcaa aatgcacagg aaatactacc tggcccatga 14640 tcccctatcc ccaaagaata gacgggaagg aaagggccat ttgctcgtag gttctttttt 14700 gcaagaaaat gttcacctct aacagctcga ctctggttta gtgacattcc ctgacccttc 14760 ccactttctt ttctgcacac tgctgttacc actgttatct ctaggcagag gtgtgccaaa 14820 ccacaggcag tcaaaagcag atctgttctg gaggggaact aaagggccac tttggaggag 14880 aatgggtatt agaggatggt tagaatcatc acctaacaca atgtggacat ctggcagaga 14940 aaattccatt aggctgaact gtctccagca aacagaaagc tggctcctca gtggtgaaca 15000 acagatgaaa aatctaaaag accacaagtc taatctcagg ctttccactg ccttgctctt 15060 tgaccttggg caggtctctt cctttctaca tctcaatttc ttcactgcaa aaggagaagt 15120 ataacattgc tattccttac agggaagtaa cacacattac taaaagtgac tataagatat 15180 acttcaaatt gcaccagaga actaaactat taatacaaat atgacatcct caaagggtag 15240 acatttcagc tacctgtatc ccttaaagaa tatgtattaa ttaaaaagag ttacactgaa 15300 aaaaatgtac caattcttaa agtaaaattg ccctattcca ggtgactcac aatgaaatgg 15360 tgcagggctt gaaggagaaa acacaagagg ggatgaatca cacatctcat gttttattct 15420 tggctattta tgaaccagtg accacaagtt atttcttttt cctctatttc ctttgaaata 15480 aatggaaaat ttcaagctgg gcaaggtggt tcatgtctgt aatcctagca ctttgggagg 15540 ccaaggcagg aagacggcct gagcccagga gttcaataac agcctgggca acatagggag 15600 atccggtctc tacaaaataa taataataat aataataata ataataataa taataattgg 15660 gcatggtggc atgtgcctgt ggttccaact actcaggaga gtaggtgctc agtagttgcc 15720 gaggtgagag gattgctcaa gtcaggggca ggtggatggg tcgaggctgc agtatgttgt 15780 gatgccactg cataccagcc tgggtgacaa agcaagaccc tctctctacc accccccact 15840 caaaaaaaaa atgtaatata cactgctttc tgcaggttaa aatcctgtgg atacccaaac 15900 cttgacatgc tctgcctcac tgggaaccac aattagcaca caggcagtca ttttggagac 15960 ttttacctaa atattcttca tttgtttttc ggacttaata ctgaaaaata catgctgtaa 16020 ctcagaaacc accaccaagt ggtgccaagt gccaagaacc atcaaagcca ttcttccgtt 16080 ctcaatccca cttaccccat cccctttctc cttctactac ctgtccccca gaagcccaac 16140 atcctgttaa aaacaaataa caaaaaactt atcgggaaag acatcagcat cctgcacagc 16200 ggctcaaatt ctgtggcatt tgcattttaa gaattagctt tgtacactgt taccccggga 16260 agccgtcatc ctataattat tattattatt attattatta ttttttgaga cggagtctcg 16320 ctctatctcc ccaggctgga gtctcgctct atctccccag gctggagtgt agtggcacaa 16380 tctcagctca ctggaacctc tgccttttgg gttcaagcaa ttctcctgct tcaagctcta 16440 gagtagctgg attacaggtg cacgcccagc taattttttg tatttttagt agagacagcg 16500 ttttgccatg ttggccaggc tggtctcgaa ctcctgatct cagggtgatc catccacctc 16560 agactcccaa agtgctggga ttacaggcat gagccaccgc gcctggccat cctacaattt 16620 taaaggaata agtctactgg gtgtggtggc ttgtacctgt aatcccagtt actcaggagg 16680 ctaaggaggg aggatcacta gagcccagga gtttgaagtt acagtgagct atgatcacaa 16740 ctactacact ccagcctgga tgacacagtg agacccagtc tctctttttt tttttccaga 16800 gacaagttct atgttgccca agctagtccc aaactccaag gctcaagtga tcctcttcgc 16860 cttggcctcc cagtgctggg attacaggcg tgagctacca tgcccagctg aggcccagtc 16920 tctttaaata aaaaagaaag aaagaaaaat aagaagtcta tgttggtaac taccaaatcc 16980 atataactgg tccttcatat gtctagtctt gtagtcttat caaactttac atgtctaaga 17040 ttattttcct gaaaacccat tcccttcacc taatgaaggg agtaggttga ctctaacgcc 17100 ctggctctca ggctccaagc ctctggaagg aatctggcta ggtgttcttc ctttcttcca 17160 tgtactcact cagtttccca gaaatgtctc tagtttttct tttatttccc ctggcatgta 17220 actatgtcaa aaccaatata tcattccagc cctggatcag ggcagccatc tactaaatgg 17280 ccttaaaggc tctatactct cgcctttgta atcagagaaa gtttccttaa aacaatcact 17340 taggtcattt cccacaaaca ataagttcct cttgccctca atcaaaattc tgcaacctgg 17400 agaactgctt gaactcggga ggtggaggct gcggtaagcc aagatcacgc tgctgcactc 17460 cagcctggac gacagagcaa gactctgtct caaacaaaaa caaaaaacaa aaaacacatc 17520 actatgtacc ccatgaatat gtacaatgat tatttgccaa tcaaaattct gcatcctcca 17580 gaagcatgct atccaaactt ctttcatcat ccctctccct ctggaggagg actcctggct 17640 ttccaagccg aaaatcacag ggatagtcac tactgtctaa ggtatttatc tgttctgtaa 17700 ttcaataagg aacagggctg acaggaaagg aaagaaaaat cctgttcaca cctagaggaa 17760 aacatggaca aaaatcacaa gtcaattgtt gtctagaact gatgattccc tctgtgactt 17820 acatagatct ctttcccctg aacttttggt cattatagtt gaaactcctg ggaatttcac 17880 ccaagttatt cacatccttg actactagag aaaagcagct gttgaccttt caaaattcca 17940 ttggttgact ttaggaactg tattgaattc gtcatgaact gccacgcaag tcatgaattt 18000 tacaatatgt gcccaaaata aagccaacca tgaaatctca ttcattccac aattattttt 18060 ggtggtggtg gtgggtatct actatatgca caaaaaccag gtagcttttt tttttttttt 18120 tggtaaggcc tgaaataggg caaataaatt aagatctcca gatttcttta ggtacttaat 18180 aatttggagt taacagattt tcctcaaggg tgtattagac actataatta atagatcttt 18240 accttctact cctttaccag ctcctacaaa gcagcaatat taataatggt tgaattttta 18300 attttatcct gcttgcagtc tgtaaacatt aaaagacagt gaaattctac aagaaaagaa 18360 gagtagtcaa aaacctataa agagtcctac actgcacaca actaagcagt tgttattttt 18420 gaaaaaaact tgcaaacaga gggccctaaa agatgacaga cagcccctca aggaaaactt 18480 cagtaaaacc aatcggatag gcaggcagaa ttcaaagaaa cagttttgag attaaaagta 18540 atattctcta aaataactaa tttgagccgg gcgcagtggc tcacgcctgt aatcccagca 18600 ctttgggagg ctgaggcggg cagatcactt gaagtcaggg gttcaagacc aacctggcca 18660 acatggtgaa atcctgtctc tactaaatat acaaaaatta gtcgggtttg gtggtgggcg 18720 ccggtaatcc cagctacttg ggaggctgag gcaggagaat cgcttgaacc caggaggcag 18780 aggttgcagt gagccaagat tgcaccactg cactccagcc tgagtgacag agcaagactc 18840 catctcaaat aaaataaaat aaaataataa aacaattaat ttgaactcaa cttcagtgac 18900 aaaaagccca tttctccacc tgttttgagg gcacacaggt ggagagctga agcaacccac 18960 cagacttcct gcagtgctgt ggctcaggcc caactggcca cagggctcac aatgctgcac 19020 ctagtttact gaaggctaac tagctgcaat taagataata taacccgcca ccaaatacta 19080 aaaggtatat taaagaattc atacaattac ttgactgaga gggtctcatg tgtggagaaa 19140 atatataaaa agtctaagct cagcagattc acatatcttc tcatattagc ccatggggat 19200 ctttaaaaga taaagtctta atgaagaggg ccatgcaggc aacaaaacaa aacaaaataa 19260 aaaaacagaa acaggtgaaa acacctccga aaagaagtgg gatgcttaaa aaacacacca 19320 aactcttccc tcctcccacc tctcaaaaaa ggtggctggg tgcagtggcc catgactgta 19380 atcctagcac tttgggaggc ccaggtgggc agatcacttg agcccagggg ttcgagacca 19440 gcctggacaa catagtgaca cccccatctc tagtataaat aaaaaattag cctgatgtgg 19500 tggtgcatgc ctgtagtctc tgctatttga gaggctgaga caggaggatc acttgagccc 19560 agaaggttga ggctgcagtg agccacgctg cactccagcc tgggtgacag ggcaagacct 19620 tgtctcaaaa aaaaagaaaa aaataacaat tagtaggaat tcaaacactc aaagaatgtt 19680 tgcaacatac atgataaata catttaaatc tcagtagtag cattttggtt tttaagtatt 19740 caaagctaga aacaggtgtt cctgtgctgt gtgggaaagg gcaatatgaa agatgcaggg 19800 cgctggcctg gcgtggtggc acacgcctgt aatcccagta ctttgggagg ccgaggcagg 19860 tggatcatga ggtcaggagt tcaagaccag catggccaag atggtgaaat gctatctcta 19920 ctaaaaccac aaaattagcc aggtgcggtg gcaggcgcct gtaatcccag ctacttggga 19980 ggctgaggca ggagaactgc ttgaacccag gtggcagagg ttacagtgag ccgagattgc 20040 gccactgcac tccagcctgg gcgacagagt aagactctgt ctcaaaaaag aaagagagag 20100 agagagaaag agagagagag ggaaggggga tggggggagg gacagagaga gagaaaggag 20160 agagagagaa agaaagaaag aagagaaaag agaagagaaa agatagatgg acagatggat 20220 gcagggtgct gaaactggga aaaccagcca cattctgctc agggccaggc taccaggcca 20280 ccaaactgag gtgtgtagtt acaggacata gactgttttt aaagcattcc aaacccgctt 20340 aaaaggtaat ttcccattca ttgcctaatt gtagcccctt tccccccaac atatttaaac 20400 ttcagagagt tgcagaagaa aataagtgct actgcataga tcacaatgaa gaaaacaagc 20460 tcttgttcat caaaaacact gctcttgttg cattgtcaat ctcaaaacaa ttctcgtcta 20520 tttgggtgtt ttttagaggt aattcatcct cgttcaaacc ttataaccct gcttacctta 20580 agagcttgta agctaaaaca tggtaatagg atttgttatt aaccttccag aaatgagggc 20640 agttaatgtg taattagcta gctggatagt cttgctgtca tactaaaact cgctattcaa 20700 gcttgtaatt actagacaat aatttagttg ttaatatcag aaaagaataa caagaggtaa 20760 cttcctgcaa ttacaagcca agtgtccata cgctgggaag actttataac tcagtaatcg 20820 taagtgaatg aagataaaac aaatcaaggt tacatttaca tataatcaag aatgaaacaa 20880 gccctaaaat cagagcccct acgaaagtag agcatagctg tggctgtctt tcagagccat 20940 accctggctg gctcatgtcc cacgatccaa aaagcctgga ccaccccatg gttttaaagc 21000 tgaccaccag tgagtgtggt atttttaatg aatgtccact aagttgttca aagccagcaa 21060 gactccattt ttatgtatat aactagttag actcctgagc cacatacacc tcatctgaag 21120 atttccaagc agacagataa agaaggttgg ttacggagct agctaagcac tgttgaagcg 21180 caaatccaca actgagcaca tttctttatt atgtacaaca ggtgacatta tcccaatagt 21240 actggacaga attgctctac ttggcctcta tctacaaata atgacatcca gctgttccaa 21300 aggcaggatg acgtttgtga ttcaacatgg acagatcaat actgaagttc tcaagctgtt 21360 caaatagtag ttggccaatt aatcatccat gaagacacat acatgtattt cttatctgtg 21420 tagttacact aaaatgttta ggaaacagca tgcactaatc cagcataaag cattatttta 21480 agatatacct tctgccaaaa tctgaattat ttgggaagat tcacagacta tctaactgaa 21540 aaggggatgg gataagtgtt aaatttgtat tttaaatttc taaatgcctg gtaaaataaa 21600 ttttaggtgc ctgtagtccc agctactcgg gaggctgagg caggagaatg gcgtgaaccc 21660 gggaggcgga gctcgcagtg aactgagatc gtgccactgc actccagcct gggcgacaga 21720 gcgagactcc gtctcaaaaa aaaaaaaaaa tttgtatctc ttgcctaatc tcaaagtcct 21780 tgaagtattc cttctgttgt agtcaatttt atttgcctgt tactaactcc ccagataact 21840 ctaggggaag acttttccca aatgttgatt tttctctcca gcaaaataag agtagaagta 21900 tctagtccac tggctagcaa ccctaagagt gaaaatgtaa actgcccaat ttcataagaa 21960 aattgtcttc cacctcactt ctccacaact tttttttttg tttgtttttt tgagatggag 22020 ttttgctctt attgcccagg ctggagtgca atggtgcaat ctgggctcac tgcaacctcc 22080 gcctcccggg ttcaagcaat tctcctgcct cagctgtccg agtagctgga attacaggta 22140 tgcgccacca cgcctggcta attttgtatt tttaataaag atggggtttc tccatgttgg 22200 ttatggctgg tctcgaactc ccgacctaag gtgatccgcc tgccttgtcc tcccaaagtg 22260 ctgggattac aggcatgagc caccgtgccc agcctacaac ttaatccatc atataaataa 22320 tttacgaagg cagtcaaaga atgagtaaaa tgaaagctgg agagagaaac acatttgcag 22380 ggatcaagca tgcctggtcc agaagggtgg gatgagagag agattaaagc tgtatcgcag 22440 tgaaggcacc tgggccccca ggagtgcagg gtgataagcc aactacagat aaaatatatt 22500 ttggagaaaa aaaggaaaac tggaaaatag aagagtgctt aaaaagctac ctgtggctta 22560 atgaactctc ctatcagtcc ttaaaattaa tttgttttga aatggaaatc cagatcccct 22620 tggctacatt ttatgtttct cagagcttct gtcactgctg tctggaagag caggaaggga 22680 tgcaaaaaaa aagatgctat catgcaggaa gccaaaatca ctttggtcat ctgctacttt 22740 ctgtttaatg tcataacaat aacaatagat aacttcatac ttgataactt catactgatg 22800 gcaagcatct tacaaaatta atccgattcc tcactataat tagctctctt gtaaggttaa 22860 ataatacaaa attaaaaatt actgggtgag taaaccacaa ttataccaat tttgaactct 22920 gaataaacaa attgcacata cacttggcaa agagaaaaca ggataagaac agaagcaatg 22980 agtcaactgg cttaccagaa atcaatggcg gggaagggtg tgaggggaca gaggactaaa 23040 tttactgcta acatgaatgt tgtttaatat caggctatga ttaacataca tctgaaattt 23100 caactgtgaa ttgttgttac gctacaaata tgtataccca cagaacagta catgtcctgg 23160 ggcaaggtaa atggcaggaa atttcacaat ccactccctg ctccctcatc gaatctacag 23220 cagaggaaag tgttgaaaca agttttaggt gccaggctta gccttttgct tttcagttga 23280 atatttatgt tgacacgcca actttctcct attagttatt tagtgttagt tttttttttt 23340 tttttttttt tggcggggca ggggttggcg ggggcagtcc tttgaactaa gattctctca 23400 ggaaccactg caggaaatga agtgattcag aactcaccaa ttatgaacta accttcaatg 23460 ccagaggctt taacagtttc taataaaaat tcagttcaga tctcaagttc agataagtct 23520 gaaaaaacac ttcaaggtca tctgaacgaa catattctac cagtacttta tataattgta 23580 tttacctgtt cctaaaactt tccgtgaaag aaatgttgaa ttttcttcag aaatagtttt 23640 gagcaaaatg tcaaaacaat tctcccatgc tcagtgtact tttgactata ctctgaaaat 23700 atttcttctt gttttcctgc acttacctgt tagtgtgctc acactcctgt attatggaac 23760 atgttcagta actcatacac atgtaacaca gaagtctgct ttcagttcac ttggaccaac 23820 gtggtttaac tcttgctgct tattaaatgc tttgcaagct aatgtaagta cactaacatt 23880 ttataaatgt gatgaaaact tactcatgtt ggccacttta caaagtagtc tatcagtcct 23940 caaatagtta aacatattat ccagcaattt cactcctagg tatataccca agagaaatgc 24000 aaacatgtct acacaaatac ttgtgcacaa atatttataa cactcataat agccaaaaga 24060 cagcaataac ccaaatgtct attatctgac aaataatgtg gtttatctac acaatgaaat 24120 attattcagc cataagaact tccgatacat gcaacacgga tcaaccttga aaacattatg 24180 caaagtgaaa aaaaaaacag tcacaaaaga ccacatatta tataattacg tttctaagaa 24240 gtgtccagaa aagacaaatc cacagaaaca aaaagcagat tcgtggttgc ctagggcgaa 24300 tagttaaagg gtacacattt atttttgagg tgatgaaaat gttctaaaat tgactgtggt 24360 gatggctgca tataactgaa tgtattaaaa actactgaat tacacacttt aaatgggtga 24420 tttgcatgtc tgtgaattat aattcagtga aactgttatt tttttaaaaa acctgttctg 24480 agacatgaag tacttgacag tcagcaaaca tctttcacaa agcttttctg gtcaatggta 24540 aaagctttag caaaactaaa catcaattta cttcattgta attggaacca gattgcagta 24600 ttttgatatg tacattttta agatgtgaat gtagtttaag aaaacacatc attacatcag 24660 atattccagg cagcctgcca tgagacattt ttaccaaaaa aaccatctta aaaggaatcc 24720 atttaatcaa gctcggagtg tatgttcttt cttgttgcct caactatatg ccatcatctc 24780 ccctaaaact ctcttgttaa acagttctgg acatgattaa ttcactcatt aagacaacaa 24840 atagtcgaac ccttattgtg caccaggcac tgttacagtc acgtgtgcgt gtgcgtgtgt 24900 atagagagag agagacgaga acaagacaaa gtcctcactc atggtgctta caatccaagg 24960 ggataagata aataatatac aaataccagt tttagaagct tattgaaaac ggggtactag 25020 ccaggcatgg tagtatgcac ctatagtccc agctactggg gaggctgaga tgggaggact 25080 gttcgagcct aggagctcaa ggctgcagtg agctattatc gcaccactgc attccagcct 25140 gggcaacaga gtgcaactct gtttctatgt attaaaaaat aattttaaaa ttaaaaaata 25200 tatatacaac tgggtgctgt gctatggagg ggtgtgattt cagatggagt agctgggaaa 25260 ggaaactgct ctgaggaagt aatatgtgag atgagtgaag aaggtgctaa ccacacaaag 25320 atcagggggg aatatcccag gtagagaaaa taatttttga acggcacaat caggtggagg 25380 cagggattaa ctgtgttctg ctggtgacca acctttctct gtgattctca tttaccaatc 25440 tagttcaagg atatctggca aaagtaactt gcagattgtg gctggactaa gaagtcttac 25500 ctacctcaga ccactaaaag gtcgtacaag ttcaacaaga agcagccatc cctggttaag 25560 ctcagcctca actgagcttt cccttctttt cttgtgcctc tcagcaatgg ttacctgtac 25620 cattcattct ttcaacccat actggtgaag ggcactgtga taagagtcct gggccttaca 25680 gatgaatcag acacacaccc gatagccctt aagataggaa ataatctagt agcacaaaaa 25740 aataggcata aacaacaaat acacagtaga aagtaaaagt ggaccataaa aaaggagcta 25800 taaaatgtaa tggtatccag agattacttc cagctggaga atcagcggaa gtatacgggg 25860 taggagcact ggagtaggta gactctatga agcctgagat ttggacatgt ggagggaaaa 25920 acagatttat ttgttgtatc cctaattaac ttcaaataca caactgaccc ttgaacaaca 25980 tgggtccaca cacagtttga actgcatggg tccattcaca tgtggttttc aataaataca 26040 gctagccctc catgtcagtg ggtttcacag ggatgactgt gggacttgag taagcatgaa 26100 ttttggtatc tgcaggtggt ctgggaactg atcccctgca gataccaaga gatgactgta 26160 ttttaacata ttttcagctc cccaaccagg tgataaggag gaaaggcctg atgctcttta 26220 taactctctg ggatattcag catagcattt tgcagagctg ggcaattcat ttgttgattc 26280 cctgtaagag atggggtgtc aatttcagca ctgaaggtaa ggctaaatta ctcttccttc 26340 ataaggaggt tttggtcttt gaaaagatga tcccctaaaa cctcttacta tatcattgct 26400 ctctcatttc agagggacat tcctaagtag ttttagtttt ttccaaaacc aaaatatgta 26460 tatattatgt gctaatacat acatataaaa tgtttgcaca tgtattcatg tgtgtgcgca 26520 tgtactcatg tgtgtgcaca tgtatcacta taccttaagt ttggaatctc aaaaaatcat 26580 tttaaacttc cacagctaaa ctgatatatt tgtacttaag agaaaacatt ttttccactg 26640 atcaaacttt cccagtcggt ccctcaaaaa tcccttccca ttaccaacaa aacatcttaa 26700 accagaaaag aaaagccaaa caacattttt ttaggcaatg tctcaacatc tccaaaaaat 26760 attccatggc caaactcacc atagagagct gtccaagttt gattaattac atctagacac 26820 acagttcctg acctgaaaca gatggaaaga atggcatgtt tttaaaaatt agaaagttag 26880 ttgcatgtat ctggcaacta atttttactt atcaagagaa atacttctaa tagatctgtg 26940 aaaaaaagaa tcccaattgg ggaaaagtat gatgaggaac agaatagtac caggtcttga 27000 agtgtcacct tacagactga aaggggaaaa tagtaactat gcaatggaga aaccagacaa 27060 cacctgaacc aggtgctgag aacacaaggg gcagacagac cttgtgtgtc tctgaatgtg 27120 ataccccaag aaggacacca tcttactttg tagttttctg gccttaagtg tgttcatgcc 27180 ctgaatctaa tgatcaggaa acatcagaca aacacaaatt gaggaacaat ctataaaata 27240 actggtctat gttattttaa aaagtgaatt ttataaaaga taaaggcagg ctgaggaact 27300 aatcctgatt aaagcagttt aaagaaacat gacaactaaa tgtaatgtgt gattctagac 27360 tggatccttt attgaaagaa aaaagtgcta aaaagtaagt tactggaata tggcagtaga 27420 ttaaataagt attgcattaa cgttaaattc ctgaatctga caactatata ctgtggatag 27480 ataagagaat atccttgtta ggataactga tacaataaaa tattaatatt aaaggactaa 27540 ggggcatgat gtatgtatat atacaaccta ctcacacaga gtgcagaaaa acctgttagg 27600 tatgtttgtg agagacagta aaacttagtg ccatgacaaa ttaaaattgc atcccaaaca 27660 ataatatatt ctaaacagca ctagaagtat aaaacaggat atgctggaat attttaaagt 27720 atcattaata aaatattaga aggaaagaag gggataaata agattcatta actgaaatga 27780 aactatagtc attttgcctt actatctatc aagaattgag aaaatattat aagatctgaa 27840 aatagtctat ctgtaggctg aaaacagatc tctgaactgt gtctacaaaa agagaagtga 27900 gatgtggaat attactactg tttgctgggt aacaagaaaa atgaaggacc cagtcacgac 27960 aatggaaaaa aataagtggt acaacagcag aatgtgaact aagtgattga gaacctcata 28020 tcctttggat tctatcattt acatgaccat tcatacagtc ctacctcctg ataaggtcca 28080 aaaagataac cgaggctttt tataacacag agaaacacta atcatgagca gttgctgcta 28140 aaattgaaac attttaaaat agttacttac gcttcatcaa tgttgggatg gaaaatttta 28200 ttcatgaatc ctgtaaaaag agatgttaat tagcagcaaa aagtatccag agaacaataa 28260 aagtatttca gtactggaaa caatttcagt attgggaaaa ggtgataata cttataaatc 28320 actactttca accttagatc tttcattact gataaacatt atattctcct gatagctcca 28380 attatttgga atacatcagc attctattaa caaatgagca aactgggaga aatgcagctt 28440 cttatacaaa acaatcatta aagcaactgt tttctgagct atgaaggtac tgctcaaaga 28500 taaattatac tactaaatgg ttcatagcca gtgtcatgat aaaagttaag aaacttcact 28560 ctcccagaag ttttgttgtt caagctctaa atctggaggt tctgcatttc aacttctcct 28620 tctgacgctc acttactggt atcacttggc tgcactgtgc acggaacatg aatgaaactg 28680 ttgaaatgct aaaggaatac cacttcaaac cacaaaggat ttcctaaaag cagtgaccaa 28740 aatatttcct ttaacattag tctactcatt cagggaaacc cagttttgat taaaattggg 28800 gcaaccaagc aaggagttaa aaaaaatact ctaagttggc tatatctgtt ggaggtttaa 28860 gtttttaaaa tttttcctag caaaccaagt acacacttta atagctatat ggccatttga 28920 acttcaagga gaaattaata aaaccagtta ttcagtcagt cagtatatat gcaaatggca 28980 atattctaaa gcagagatcc attgtcaaag gtgtcatttt gtcatcctta tcacttcatt 29040 tccttttagg actcattctg ttccacactt tcaatatctg aagttcctta ttaaggtgag 29100 tatcaccacc actatctccg acccccatcc tccatcaccc ccatccccac agtctctctc 29160 tctcatattc attcagaaca tatttggtca gcacctacac cgcaggcatt gtgcttggat 29220 agggtataaa aataagacag ttcactattc ttgaggaggt cactgtggca gtgggacaag 29280 agacaccaat aaatacctgc aatctgaata aagtattgat acagtaggcg gagtaaaatg 29340 ggaagagtca ggaaagatgc agagaaatgg cactggagga ggagcctcaa gtgaggcgct 29400 acagagattg tctccaaaaa cctgagaaac ttcccctgaa gtagaaaaca ggggataaga 29460 ataccaagtc caagtagtcc agtcttagac cactctagtc actcacactt ttaacttttg 29520 tttttaaatg ctctgtgttg aaacagcata atgttctatc tactacaatc aagagggcct 29580 atgtgatgtt taagttactc tgatgaaaaa aaatctttgt gtccaatatt aatttttcat 29640 taaggaaatt aaagatgttt caaagtctag atttaagaag catgtggttt atgaagacat 29700 tttaataatg ggaaatgttc atgtcttggt attaagagga gaaaaattag ggtaaaaaac 29760 attctacatt aactttagaa aaatactaat acacatgtcc cagatgcccc atgagagtat 29820 ttgttgcaat attatttata aaagccaaca gccaaattca accctgtcaa tgggataggg 29880 ttggataaag gggagtacat ccatctacct gagtcctata cagccaaggg taatgaagta 29940 gatccatgtg tatcaacttg tatacatcta aagctgagtt ttgttttttt tttttaagtt 30000 gcaggatgtt atatttacag gctgaggtta tttaaataaa ctaaaacaaa caactaccaa 30060 ttctccatgg taacaagtat aggaaaactg tactgaacca acatatacca aatttgcaaa 30120 agtaattgtt tcagttaggg cacagggcca gggtcatgat aggaaaaggg aacagaagag 30180 gaaacagtgg ttaaaaatga ctttatctgg ccaggcacgg tggctcatgc atgtaatccc 30240 agcactttgg gaggccaagg tgggtggatc acctgaggtc aggagttcaa gaccagcctg 30300 gccaacatgg tgaaaccctg tctctagtaa aaagaaataa aaaattagct gagtgtggtg 30360 gcgtgtgcct gtagtcccag ctactcggga gaccgaggta gagaatcact tgaacccagg 30420 aggcggagct tgcagtgagc caagatcacg ccactgcact ccagcctggg tgacggagtg 30480 agactgtctt taaaaaaaaa aaaagacttt aacactatta atatattcct tttaaaaagg 30540 gacaatgtgc ttctatatta tttgctctgt ttaaaacata tgcacataaa taagaaactg 30600 aaagtaagta caaatgttaa cagtgtagaa ttcttagtgg tggtagtatt ttctccgctg 30660 cacttttcaa atctcatcac cacctcacca cacctgaacc agaactagga tcacagcaat 30720 gggaaaaggc tagaagaaaa caggtgtgga tggttgtcat gtttgcaaga ttctcccatt 30780 atttctactt gcacttttgg ctctctgaca tttctacaat gtgtaatttt aatagttgag 30840 cttaaaaaaa ctccgaaata aaaagttatc atagtatcag ctggccacag tggctctcgc 30900 ccgtaatccc aacactttgg gatgctaaga cggacggatt acttgatgtc aggagtttga 30960 gaccagcctg gccaacatgg tgaaacccca tctgtaacga aaatacaaaa attagccggg 31020 catgtggcgc ccacctgtag tcccagctac tcaggaggct gaggcaggag aattgcttga 31080 acctgggagg tggctgcagt gagccgagat catgccactg cactccagcc tggaagccag 31140 agctagactc cgtttccaaa aaaagttata catagtatca aacattctaa aatagactga 31200 attacacaag cattaactag tgctgaacta ttttaagaaa aagccagtaa aaccaaccat 31260 tttatttgaa atctcgtatc ttaacactct tgttcaaata atacaaattc attaccctcc 31320 ccctaaaatc agaggaacct caggttataa ggtacgtggt cctcaagatc agttatatat 31380 aggagtatgc tgctatcact actgcaggga agctttctga tgagtgggga acaatgctga 31440 gccactatgt ggtttaatgc aagagaatgg tcctactata tgaaaaatat tgcctgaagc 31500 tactattaag aattaaaaat acgttcttga tacttaaaat cctgcctctg tgagaactct 31560 caaaactaac acctaatgaa gcaacgtcta tggcaaaggt tcccaatgct ggctacagat 31620 gagaagcact gggaagtttt catttaaact aaaaccaata ctcaaagaca caggacttaa 31680 ggggaaatac ctgtaaggaa aggtctttag aaaaaataag tcctacatta gaaggtcacc 31740 agcattatgg agaaaaacac agcaaaggag gaaaacagaa atggaaaggt tggggcgggg 31800 tggcaatttt aaatgagatg gtcaggaagg gacttcctga gaaagtgact tgctttgaag 31860 gaggtgaaag aggagccacc tggtaccaag aggagaggag aaggtcacta tagagggaac 31920 agccaagtgc aaagcacatt aggagcttgc ctgatgctct gaagtttttt cctgaaactg 31980 aagggatttg aaaaaggggc agaaaatgag aagtgatgtc acagaggtga tcagcatttg 32040 gggccctttt aaggacactg gcttttattc aagggagatg ggggggccac tgagactagt 32100 gcctgaacag tgacatattc acatacttgg cttaacaaat ggcttgtgtc ctaaaatagg 32160 ctagttgggg aacagctcaa tcagctcaca gcacctgagt gctggggaat ggcagatctc 32220 aagcaaaaca aaatgggaat cctacagggc attatgcttc aacgatctga ggccacgggg 32280 catttaaagg tgttaagtca agcaaataac tatggtaagc tttaaatgtt tatcaaaacg 32340 tctctgaaag actaaggtgc ctccctcatt ggacatgacc tggagagcac acttggaatt 32400 aacagtgtct atacagtttt caattaaatc tagatttggc ttagttgagt acaggaataa 32460 ataacagaac caaaaaggac ttggtaaaca tacgctttag taataaatgg tttggagctc 32520 agtctccagt gcccctgcta agtacagaac accatctgag cactagtaca gagggcagaa 32580 tcacaccaca aagcaaagta ctaaacaggg acatgggttc tagcctcaac taatcaactg 32640 caggccctgg gcaagtcact tcaccttgtg gggtctgttt ctttacctac gaagacaaat 32700 agttgaacta tatgatctcc caaatctcca ctcttactct atttctgaag gccctatcag 32760 ctctaaaaat ctagcattta ataacaatgg caagcactct gagaacagag gaattatggg 32820 gaaatatcca agagttaagt ccttaaagga aattaattct gtaaggcagc atttttaggt 32880 acagaaattt tctagagaat acaaaaccac caacatgata aaataccata aagagccaca 32940 aaacaaaccc tctgactctt ctaaagtagg cagaaacagt ttataacctt gcctttgagg 33000 gatgaacaca accagaccaa ctctatcaag aaactttcta ctttctaaac taaaatgatc 33060 tcttccaata ctaggtgttt tttttttttt ttgagataag gtcacttcgt cacccaggca 33120 ggagtgtggt ggtgcagcac cttgctcact gcaacctccg cctcctgggt tcaagagatt 33180 ctcctgcctc agcctcccaa gtagctggga ttaccacaac cagctaattt ttgtattttt 33240 tcgtagagat agggtttcac catgttggcc aggctggtct tgaactcctg acctcaagtg 33300 atccacccac ctcagcctcc aaaagtgtgg ggaattacag gcgtgagcca ctgcacctgg 33360 ccctcaggct taattgttag aaaaatatcc aaagcaaata catggaaaaa agcatatctc 33420 cttgacattt gttcttagac aagctgtggg cagtgtttct ggcaaagcca tttacattct 33480 ggataatgat gccaacaatg gaactcctgg acaaggaggg gggagacaga gaaagaacgg 33540 gccagaaatt cggaaaagga atgttctcag gactgtgttg agttggccct ggcatgttct 33600 ccttcctttt ggcaatgcta tcatcacatt aatgaatatg tctgcaacaa gggaattttc 33660 ccaacacttg tttccattag accaggaact attttcaaga tattttaaga gaacatattt 33720 tgaaaactgc ttttatggca acataagtag aagtagcagg ttatttttaa tcttcatgat 33780 ttaagatttt attcactacc aggcattttc tttttctttt ctttcttttt tttttttttt 33840 gagacagaat ctcactctat cactcaggct ggagtgcagt ggcgatctcg gctcactgca 33900 gcctccacct cacgggttca agctattctc ctgcctcagc ctctcaagta gctgggacta 33960 caggtgccca ccaccacacc cagctaattt ttttgtattt ttagtagaga tggggtttca 34020 ccatgttagc caggatcgtc ttgatctcct gacctcgtga tccacccacc tcagcctacc 34080 aaagtgctgg gattacagga gtgagccacc gtgcccggcc actaccagac attttctaac 34140 aacatatttc agtgatttga ccagattaaa atcagaactc cttaagtttt ttggacagtt 34200 attctctggc gtagttctag cactcgttaa aggggatggg gaggatcgta caacaggaat 34260 aaatgtccag ctaaaatgct tacccttctc tgtcctgcgt cttttagcag aagggaatta 34320 ggtaatttat aattctggag aaggaatcca aatcacactt aatgtaaaac tattattata 34380 tatcttaaaa aataaaaagt acagattaca acagaaaaat atgccttgct tttgcttgtt 34440 ccactccaat actcaactgc tctagaataa caaatctcat gacccatagg ctaataggca 34500 gtgaaaataa ataacattgt gctaagtcat gctgaaaaac tggtttttat ttcagcctct 34560 gtgtccagtc ccaggaaggg gtctatacag agttgcacac acttctgagt aacttctgac 34620 attggggtca atatgtaaat aaatgaggcc aagcttcacc tatttttcca tctttgttcc 34680 ctttatttga gaggatatta atgatcaaat ttgtgggtag atgaaatact ttgggccaat 34740 caccagaaat ttcacctgtc agaattatct tgacaaaagg agaggttaga caaacgactt 34800 gtgaatcaag gtaaatccac cctacggtaa acgggtgaag atcaccaaag gccaaaacag 34860 cagctacatc ccagggataa aataagccta ggctaaggtg gttcagacag ctgtggctga 34920 tgcaattgca ttataagctt atgaattcct gtgagaaaac agttaagtga atacattaag 34980 tcattctgat cgtctatctt cagaacaact gcccacataa agtagactgt tcacaaccaa 35040 actgattaat tctatttttt cagtaggtat aattgtttaa aatattctta ttaaagactg 35100 aatctcatct tcccttgcag tatctcagac tataaattat ttaagggtaa taacttggat 35160 ctctgttcct agcacacagg gtgaccagag taggggtgtt ccaattgagt aagggtgggg 35220 gggtgctgcc agctccacta gtgacagaca ttggccagct atgtgcagga gtccacaatc 35280 tgatagattt tcatctaacc tcagacagcc aggccccacc tgaggcagcc tgtgcccggg 35340 tagaaatctc ttcagaaatc tgagcctttc ctactcagga gagatggacc tgggcctgtc 35400 tcttcttggg tgaggaacca ggcaaggagc tcactctcaa tgccctgtgt catgggaact 35460 tctgaactga tcctgtgtgt gttcaggaga tctaaactca acaaggggtc ctcttttctg 35520 tttcttcctt tctctctggt aatatagagt ctgaggaatg ggctagatgg ataagaaaag 35580 gtcatttata actaagaaaa ggtgaagtgt tatccttcaa tagcataacc cttctaccaa 35640 cctagtggat tatcaaaacc tctggcctac tttcctttgg tttcattttt gggagactaa 35700 cttctgtttt gttttcatag tttatctttc gatcgctggg tcgttcatat aaccacactg 35760 ttgggttcag gcagtactta ttttcatggt cagagacaat acagtacaga atacattgga 35820 cttgaactca caagacccaa ctacaattct ctaccactct tagagttgta gttaaaagat 35880 caggctccaa aagataaatg tttgaggtga cagatatccc aattaccctg ttttgatcat 35940 tacgtattgc atatatgtac caaaatagca catgtacccc aaaaatgtgt gtaactgatg 36000 taacaataca ttttttaaaa aggaccaggc tccagtcaga atgcctaaat gccactgtgt 36060 gagcctctgg ggcaatctac ttcatctctt tgcctttctg ttcccttatt cctaaaacta 36120 ggttaaataa tggtatctac acatcattaa tcgtgaagat taaatgagtt aatatatgta 36180 aagcatttga acagtaactg gcatacagta agcatgcagt aatgttagaa ttagcttaat 36240 aagttaaatg aacaagtaat ttcatcttac tgtcttcatc ctaaaactga ttaatattta 36300 ccctatgtgt ccatctctta atgctcttac aagtgtgaag aacatgagag gatattatga 36360 tttacatatg tttcccataa ctctgtcaca ctagaaatgg aaaatacaat tataattttt 36420 atttttaata tttattattt gtgtgacaca gccccaggag gtcctgagaa catgtgcccc 36480 atatttatta ttaagaagac catcctacac atgcacacgt atgtttattg cggcactatt 36540 cacaatagca aagacttgga accaacccaa atgtccaaca atgatagact ggattaagaa 36600 aatgtggcac atatacacca tggaatacta tgcagccata aaaaatgatg agttcatatc 36660 ctttgtaggg acatggatga aattggaaac catcattctc agtaaactat cgcaagaaca 36720 aaaaaccaaa caccgcatat tctcactcat aggtgggaat tgaacaatga gatcacatgg 36780 acacaggaag gggaatatca cactctgggg actgtggtgg ggtcggggga ggggggaggg 36840 atagcattgg gagatatacc taatgctaga tgacacatta gtgggtgcag cgcaccagca 36900 tggcacatgt atacatatgt aactaacctg cacaatgtgc acatgtaccc taaaacttag 36960 agtataataa aaaaaaaaaa aaaaaagaaa accaaaaaaa aaaaaaaaaa agaagaccat 37020 cctttcttga tgtgcaagca aaaattagat taaaaaaaaa aaacatcctg actgcatttg 37080 gtatagttaa aaaacaagca cacacacact aaactggaag ccagaagatg gactctgcaa 37140 ctagtgcgta gtcatacatc tcagcctcat ttttttccat ccttaaaatc aggcaaattg 37200 gatgtcataa tctctaaact tccactaaca acacagtttt caccaacacc aggaatataa 37260 gcaaatctca aactgtgaac aggtttctaa aaagaactaa gacattgctt ttgttgtttt 37320 caaaagaatt tcagtttaaa gaaaaaggaa gccaaaaata cttgttttca ttatgacacc 37380 aaatcctaaa gggaaagaaa tagatttaat gccaaaaaga tgtcagaata accagctcaa 37440 aagctagagg tcacccaata cagagtagga actaacctag gcagcaagtg tgatggaagt 37500 tttaaatagc aaatgaaaag attatataat aatgagctgt caaaggcaga attaaaactg 37560 gcataagtca acttcaagaa agaaatggac tgtaatccca gcactttggg aggccgaggc 37620 gggtggatca tgaggtcagg agatcgagac catcctggct aacaaggtga aaccccgtct 37680 ctactaaaaa tacaaaaaat tagccaggcg cggtggcggg cgcctgtagt cccagctact 37740 cgggaggctg aggcaggaga atggcgtgaa cccgggaagc ggagcttgca gtgagccgag 37800 attgcgccac tgcagtccgc agtccggcct gggcgacaga gcgagactcc gtctcaaaaa 37860 aaaaaaaaaa aaaaaaaaaa agaaagaaat ggacaagtcc tctgatagta acaagcatat 37920 gcaaaagcag ggttatcctt agaggtggca gcctggggaa tggggtggga aagctaactg 37980 tactattttt actctggcta ataacaagat gaaggtaaat gaatttagac attacagcct 38040 gctcacagca ggtttcacat taaaagggcc catttgacca ctggcttctc tcactgagaa 38100 cttcagcacc tggcttggcc cccaagttgc tctctgcccc aactcctgtc atttttggtg 38160 acaatataga ccatactcct gacacccggg tctctctctc tctctttttt tttttttttt 38220 tggagacaga gtttcattct tgttgcccag gctggagtgc aatggcgcga tctcggctca 38280 ctgcaacttc tgcctccggg gttcaagtga ttctcctgcc tcagtctcct gagtagctgg 38340 gattacaggc atgtgccacc atgcccagct aattttgtat ttttagtata gagacggggt 38400 ttctctatgt tggtcaggct ggtcttgaac tcctaacctc aggtgatccg cctgcctcgg 38460 cctcccaaag tgctgggatt acagacgtga gccaccgtgc ccggcttgtt tcttaagctt 38520 ctcctcagtg accttctatt ccattccact tcatgctccc caggacatac cctgaccttt 38580 gtcattccct ccacaattac atatttacct ccacaatcac aaatttagac atctcctatc 38640 ctaccaatcc cctgtccttg ccaaaagctt cccaccccag gaatcattaa ttctttcacc 38700 tgttaactgt aatccacaga ttctcccatt ttcttcccaa ctaccagccc tcttatcttc 38760 actggcttct tactcagctt aagatttaag agccatcacc atcctcactc tcaagcaatc 38820 ctctgcaaat cccctgtcct ctcccctcca aaatgcccat ctagcaaagc taccacagga 38880 agcatcattc acatttgctc aacttggact tgagggtacc agtaggtagg cattcattca 38940 ctcacacgaa tattcttctg cagaaagggc actgtatcag gccctgagta gtgagtattt 39000 gggaggacag gggtggtggt agcaaaacag acccaggggc tgccttcatg gagttcacat 39060 ctactgagct ggcagggagg agagacataa gtaaacaaat atataccagt ttatctaaac 39120 atgctcaaca gcctttcttg gactcagcat cacctacaat cttcccttcc cctttctcta 39180 gtgggtcgct cccccagtct cccatgactg ttacatttta ccacaatcct gcaaatctac 39240 tttctttctc tccctttgtt cccctaactc tctcctctag ttctttcact aaatagcctt 39300 gtcccttttc tttgagaaga tgaaagccaa ttggcaggat tcttcatttt ccataaaaat 39360 ttctaaactc ctccctgcac acatactctt tctccctgcc tcaacagctt gcacacatgt 39420 tcccctcttc tcaaacacca ggcctctggg ttctgatcct gctccctcct tccttctcga 39480 tggtggtgct cctgcaattc tcttcccaac tccagcatca ccaagctctc ccttttctaa 39540 acatctctct acaataagca ctttaaaatc cttcagaatc ttccatttaa aaattaaaaa 39600 caggccaggc atggtggctc acacctgctg tcccagcaca ttgggaggcc aatgtgggca 39660 gatcgcttga gtataggagt tcaagaccag ccagagcaac atggtgaaac ccatggctac 39720 aaaaaatgca aaaaaattag ccaagcgtgg tggcccatgc ctggagtcca ggaggtccaa 39780 gctgcagtga gccacgatta tgccactgca gtccagcttg gatgatttcc ttaatggagc 39840 cacatgtctt cacagcggtg tatgtctaga acaaagtttc ttgaccttgg cagccttgtc 39900 caagccacca gcatctccgg ctacaaaagc ttttataact gtgcttctat cccgtcactg 39960 tgtcttgccc cacagcagta gaatgatcat taaaaaaaca aaatcagacc tttcactccc 40020 ctgctgaaaa ctatgtaatc tttctattac atttaaaatg aaagtcgagc ctttaacctg 40080 gcctacaaag cggtctgtga actcaaccct gcctgccact tggcccgtgt gtcacacacc 40140 tcacatttta cccagttttc caggctgggg cctttgtact caaaatttct tctgcctgga 40200 aagctcttac ccctgatttt ggaggatcag ggctggtttt tgttttgttt tgtttttaat 40260 ctttttaagt ctcagcttaa atttactttg tcagaccctt cctgaatatc tgatccaagg 40320 tacctattct atccattaat tctctgcata aagctatcag aagttttaaa ttttgcttta 40380 tcttcgcact ccaaaagaac ataaagtatt aagagagcaa tttgttcact tctgtatcta 40440 cagcacccag aataacgccc agctcgcagt aggtatccaa taactttgtg aaactgattg 40500 gaaggatgat gtatgccaca gccaaagcct cagctgccag acataatttt tgaaaaatgt 40560 tattttcaga acaccagtaa aagagctttt aacaatggct tatattctca tagcattatc 40620 tctatttatt tttttacaaa accttcctta cttactagaa ccttgtttct ctctactgga 40680 attcaaaaga tacttatcat tggccaggca cgttggctca cgcctgtaat cccagcactt 40740 tgggaggcca aggcaggcag atcacctgag gtcaggagtt cgacaccagc ctgggcaaca 40800 tggtgaaacc ccatctctcc tacaatacaa aaattagctt ggcgtgttgg cacatgcctg 40860 taatcccagc tattcgggag actgaggcag gagaatcact tgaacccggg gggcagaggt 40920 tgcagtaagc tgagattgtg ccattgcact ccagcctgca caacagaaca agactctgta 40980 tcaaaaaaaa aaaaaaaaga tatagatcac tacagagtag ccattatgta actgtttggg 41040 acaggactaa agtcataacc acggttatta gagaagtaca caggtgatct gaatggaatt 41100 ttgcctcccc agccccaaaa ttcattttat ttgagacgga gtctcactct tgtcgcccag 41160 gctggagtgt agcagcgcca tctcagctca ctgcaacctc tgcctcctgg gttcaagtaa 41220 ttctccttcc tccgtctctc gagtagctgg gattacaggc acgcgccacc atgcccggct 41280 actttttata tatatatatt tttagtagac acggggtttc accatattgg tgaggctggt 41340 ctcgaactcc tggcctcaag tgaacctcct gcctcggcct cccaacgtgc tggtattacg 41400 ggcatgagtc atcgtgccca gtcacagaat tcattttatt tgtgaaaata cagtggtaca 41460 agtaggcctt tgttaaatga ctaacctgaa acctcttgtg aatgacaaac tcctctctac 41520 tgcaaatact ggcccatccc tgcttaaata ctgctcaatg aagttactca tgctagttct 41580 tgagggagta actctagaat gattccatct aggaagacat aagataaaat ggtaagtatt 41640 ctaagttcta taggtagttt agtcatgcca tattataaac ctccactcca aaaatagtgt 41700 gaggtcattt ctggccagag tgaaataaaa aatgtataat gcctgaacag tctattattc 41760 tgacaatgaa aaagattaat gcagttccct ttatcacttg catgagtaaa aaaatatata 41820 tatatattgg ctgggcgcgg tggctcacgc ctgtaatctc agcactgtgg gaggccaagg 41880 tgggtggatc acctgaggtc aggcatttaa gaccagcctg gccaacatgg tgaaaccccg 41940 tctctactaa aaaacacaaa aattagcagg gcatgatgga gcatgcctgt aatcccagct 42000 actcaggagg ctgaggcagg agaattgctt gaacccggga ggcagaggtt gcagttagct 42060 gcaatggtgc tgccactgca ctctggccta ggtgacagag caacactccg tctcaaaaaa 42120 aaaaaaaaaa aaaaaaaaaa agaattatgg cacactggtt atcagagtat atgccagact 42180 gggagattta agaggaactc tgacaggctg tccagtctag tggaacaggg caacctaaac 42240 catcctgata gtttgaccca attttaaagg ccattaatat agctcagagt tttttttttt 42300 tttttgagac aagagtctcg ctctgttgcc caggctggag tgccgtggcg cgatcttggc 42360 tcatgcaagc tccgcctccc gggttcacgc cattctcctg ccttagcctc ccaagtagct 42420 gggaatacag gcgcccgcca ccatgcccag ctaatttttt gtatttttta gtagagacag 42480 catttcactg tgttagccag gatggtctcg atctcctgac ctcgtgatcc acccgcctca 42540 gcctcccaaa gtgctgggat tacaggcatg agccaccacg cccagccagc tcagagtatt 42600 ttaactattg tattgcccat gactttttca ttttgtctcc atttactcaa atgggtttgg 42660 caagttcttg cttcatgcca ctaacatcaa attctttttt tttttttttt ttttaatttc 42720 ttgagaccgg tttcactctg tcacccaggc tggagtgcag tgatgctatc tcagcacact 42780 gcaacctctg cctcctgggc tcaagtgatt ctcccacctc agcctcccga gtagctggaa 42840 ctaaaggtat acaccaccat gcccagctaa tttttgtatt ttttttttta gagatggggt 42900 ttctccatat tgctcagggt ggtctcaaac cccttgtctc cagtgatgtg cccacttcgg 42960 cctccccaaa atgctgggat tacaggatga gccactgcgc tcggcctcac atcaagttct 43020 atggcagcac gagcttgctg gttttgtacc tgaccattct accaacattc agcaaaccat 43080 tcagcagtcc ctccagaatc ctgttctcaa ccatttctct taccttccca gctttggtat 43140 catcaaattg caacccagag gcaatgcata cagcctgctc ctagtagagg gtcctcctca 43200 ctgaaaatat gtagatatag atcggtagca tttcacaaat tggtttctaa acttgttacc 43260 tgtaccttat aacacagttt tctaattttt aagaagtata aatgatgaca gggttcctag 43320 gctgctctta aagttattta caaaagattc taaaatattc tatagttcta tctgaaatta 43380 ggatacaatt ctgttaatag tagccaataa tcatttaaat gtaagataaa atgacatctt 43440 aattttatct ggaatgctag tgtttaagta aagtagatat gatatgaagg agaatataat 43500 agatccagaa gagaacttct ggatgttgca agatctttag tggctataag ccctgaattt 43560 aatttttttt atatatataa tttttttttt ttttttgaga cagagtctcg ctctgttgcc 43620 caggctggag tgcagtggca cgatcttggc tccctgcagg ctacgcctcc taggttcacg 43680 ccattctcct gcctcagcct cctgagtagc tgggactaca ggtgcccgcc accacgccca 43740 gctaattttt tgtattttta gtagagacgg ggtttcactg tgttagccag gatggtctca 43800 atctcctgag gtcatgatcc acccgcctcg gcctcccaaa gtgttgggat tactggcgtg 43860 agccaccaca cccggccctg tatcttttat tagaagactt ttatattttt tttcccttgg 43920 cttaggctta tcaaaagtat ccccattatg attattagct ctaaagaggg gcatttttca 43980 gttcatatga agagaaaaat gcaacaacgg aagggggaag tggaagagtc aggcagaaaa 44040 gaaaaaggtg agaagtactt gaggtaacca cccaagagaa gagaaaaagg gggaagaaag 44100 aagtgaagaa agttgcgcgt aaagacagta tctgagatgg actaaactct aaactctaag 44160 cagaaaacaa aggaaggaaa acagtgtgtg cacttataca cacacataat taaaatttaa 44220 aggaaaaaag aagggaggct gctgggaaac acgtgggtta ggcaggtcct gagcaagcta 44280 ccacagggaa ttctggccaa gcctgatggc tttctagagc aaaagacagc aaagtgtaga 44340 ctcagacaat gatacagaca ggacagtcaa aagacataca tttgcaatat gattaaaaat 44400 atttactttt ataataaaag caaacattgt agactatttg gaaattacag aaaagtatgt 44460 ttttagtctc ctttaactga acagctatgg ataacatcaa tagtttggca ttcaaatgtg 44520 aaatgtatag gaaaaaatta gagttgtact atataaaaaa cattttcctg tgtgtccctt 44580 caaagaggtg ttaaaacatg actaatgggt aaaacatttt atccactaag atgcactatc 44640 acttagctac tttatcaccg actgggtcat ttaggttgct tctgactttt aagtattata 44700 acactaaaat ttacgtattc ttttgacagt gcacatttct aaatatttct ttagataatt 44760 tttaactttt taaataaaat tatttgaagg atataaaata tttaccaagc aatacatagt 44820 ggtagactgg ctgtatcata ataccttttc taacactgtt ttatctgcca gtttgacaaa 44880 tcatatactg tactttcgtt ttaatctgca ttcttttgga ttagacataa aaccattttg 44940 tatcctctgc ttattttttt ttattaaaaa ttactctgta ttaccctctt ctatgagatc 45000 attcatcttt atttcaccca cactgtaact gcaagtctgt ttggtgaaag ctttcactta 45060 acagctgagc acaagtatca aaggctaaaa actgtgaacc tcgagaagtg tgagctatgg 45120 cagtctctgc agcaatttct ttgcataaaa caaaatcttc atgaactggg gattacttgg 45180 ggttctgaat gagtatctct aaagtcctca tgcacacctc aacaactctg aagcttttgt 45240 gaagacaatc tctcttgtag aaacttatgt cttccttacg ctctctcttc taaattgagg 45300 tgctgactca cacctctcct aaaaaacaat ggaaccatgc cattaagtac acgtagtatt 45360 ttatttacat tcttcttctc tcctaaccag taaagatctt ctgtagcctt cgtcatgtcc 45420 agcaggatgc caggtacccc gagttttaat acactggtca tatcaaacat gcagaatctg 45480 tttaattcta gtatctcatt ttctagcaga gaaaacaatg ggtcagctgc atatctctct 45540 catggtcaag gagaaccagg gccagaactt ctctaccctg ataaccagtc cactgaccaa 45600 tcacactctc ctaactccta cacagtaaca cccagcagta ttgctaagca ctctaggaac 45660 taatgtttct gaatgaaaaa tatgaaagtc tgaattttca agtaaatcag aaaaagattc 45720 aaatatgatt catctcaaag cagtctctct ggaaaattat gcaaatattc agcgatgtta 45780 tagttgatta aaggagtttt atatctttta ctcttttcaa agtgcctaga gggccggttt 45840 tataccccaa ttgatattac tcgtttttcc attcatctta ttctttgggc ttaaatgact 45900 gttagccatt tcaaaaattc acatccagct tcaaagcatc aagatttgcc atcacttatg 45960 atactgaaac agaagtaaaa ttccaaaaaa aagagctcaa agtgtttgaa acaataatgg 46020 catcataaga ataagttcat aacctcccaa ggtgtctacc tatattcctt ttctttccaa 46080 aaagtagcta tgccactatt tcgaataccc actcatttat agatgcaaat tgttttaaag 46140 ggacatctca tgcaatcatg taactactga cagccctcta aaactatatt tggagagtgt 46200 cccaaagata agcatatcac attatattga atatatatat ttaaatattc agagagaaat 46260 gtcttaaaga gcatattcca gaatgtaaat aatgacaccc tttaagggat aagattatga 46320 gacattttga tttttcttta ctttggctta cagattttct tacattgctc taatggatat 46380 gggtcattta tacaattaaa atacacatcc atacacaaac acacaaaata gaacaaagta 46440 catagacact gcaaaattcc aagagccaag cattaaagat gtttgatcta aatttgcaca 46500 gctgattgtt taaaagctca aaatttggct caggaagaac actacaccta cccagataca 46560 acaggggcaa gatttaaaaa gaatgttgag attgggttga tcttacctcc tcgcccttct 46620 gtataatttt acaactatct acacaactca aaaaggaatc cttgcctttt ctaagtgagc 46680 cacaaccttt ctgaatgctt aaagcacatc tcaacagtaa ttacactgtt gatgacctga 46740 aaatgggtca ccccgcacaa ctgattgaaa ctctcttatg caaccttcct ctagaggaaa 46800 caagaacagc ttgtacaaat atttcagcta aatctacttt ccaaacagaa gatgatacac 46860 atttgtaggc attatcaagt cctgaaagca cacagaaagg caaaagaaac aattatgaag 46920 aagttaaatt agcttagtca tttgtcccaa ccaaatttca tattgcatca ttaatttaag 46980 aaagcgtgga ggctttttgt gtcattagtt aataaacaag caatgcctaa agtttagaca 47040 ttattaccta gaaagttatg atgagataat catattatct agaaaaaata cattaaggtc 47100 tgagaaataa catttctaca ggatatgaaa ttgcatttct ataagttcac tcttagtttc 47160 aacaagctct attgtttcct ttctgactag gaatgtgggg ttaacaaaac tagacttagc 47220 atgccagttt ttagccttta ggtaaacagg tatttatgaa atgtatctga atgaacttgc 47280 atggacttct ataaaggctt taaagtccta tcactaacca acataagagt tttaaatggc 47340 tgagtagaca gaaacaccct aaagttagaa gatgaataaa ctggggacag ggaaccacaa 47400 cacaacagaa aagccctctc aaaaggagaa ggtgtacagg cgtatacgtt tctacaccta 47460 tacaggtgct aagtcagatg tgctcggggg ctgtctcaaa ggctcaacac ctcacagctc 47520 cactcccact ttaccattca caacgctgaa acttagaggc ccctatagca agaaagaaat 47580 ttctgattca actggttagg agtgggggtg tagtggggag tggtctagac tccaggatat 47640 cgggcattac ttcttaagac agcccacagc agccaggcgc aatggctcac gcctgtaatt 47700 ccagcacttt gggaggccga ggctggcgga tcacgaggtc aggagatcaa gaccatcctg 47760 gctaacacag tggaaccccg tctctactaa aaatacaaaa aattagccgg gtgtggtggc 47820 aggcacctgt agtgccagct actcgggagg ctgaggcaga agaatggcgt gaacccagga 47880 ggcggacctt gcagtgagtc gagatcgtgc cactgcactc cagcctgggc gacagagtga 47940 gactccgtct caaaaaaaaa aaaaaaaaaa aaaagcccac agcagtagca aaatgtttga 48000 actctggcaa ttctgaacat gaggcttagt ctgattctca gagaatgctc aatatattac 48060 aattttattg ttcttactta aaattgttca atattttata atattttaga catgtataaa 48120 gtgaagcaaa aaaaaaaaaa gctggcttaa attaactaaa ttactaccat tctacagtct 48180 ccaaatattt aaaggtgtcc accttcaatc agatagatct gtcactgagt gcctcaatgg 48240 gggtgacagg taaataacat cacccattaa ggtaaaagga gatgaaggtg aggagaaagt 48300 acctctttgt acaaccccac tgaggtttct attctttctt ctgctgttta gggggctaaa 48360 gagactggag gtgggaagac tgcaaagggt catttaattg taaggtaccc agagttggag 48420 tgaacaaaaa agcaaagtag gatctaggga gaatttctga aaatgatagg attaaaacac 48480 atactatgta acattcattc ttgcaatctg gcattcaaaa ttagacttaa gatatgttta 48540 ttattttcct gctaacagct taaagaacag tggggcctta aagctggttt aatctgacac 48600 caaaagacaa aaatctaaag taatggtcat tataattatg caaagagtat atttaaacgt 48660 cttctaacac actatagaag ttccccccaa aagtcactga ttaattaacc aaagccaaaa 48720 aaggaaaaat tcaattagac agccatttct ggcattaatt acctcccctg aaatgtaaga 48780 tttttccccc ttagatttca aaactctcta aggagaaaaa ccaagtagta acatacctat 48840 agatggagat ttgaaagggt atttatcagg taggtccact ctaactttcc atactccgcc 48900 ttcatatggt gctgaaataa aagtaaaaat gttcatcaga actacatctc caaattagaa 48960 aataaatctg agtgtaaatt aaacattatc ccctaatctt ctgaaaacct tccaaattaa 49020 ttccttcaag agtcagggac ctactacaat caataggtgt accacgttca gattaagata 49080 cttttcttgg aaagatccag agttaaaaaa taagcagatt cattctgcaa tttacttgat 49140 tcttcaaaag tactaaacac tattcaatta tttggtaagt aatagccatg ttactttccc 49200 tcctatctca ataaacccca tattcatccc ccctccaagg ccaaaaagaa aacaacaaaa 49260 aacatttcct ggaaaccatt cacgtggcca tccataacaa aacccagaat ttacaattca 49320 tgtctagtac tgtcacatag agataaagag aaaactacag tcagccctct atatctgcag 49380 gttccacacc cctggattca accaaccaca gatcaaaaat attagagaaa aaaatccaaa 49440 caataataaa taacaataca attaaaaata acacaaaaaa aataccaaaa aggacaagtg 49500 cggtggggct catgcctgta atcccagcac tttgggaggc tgaggcgggt ggatcacctg 49560 aggtcaggag tgcgagacca gcctggccaa catggtgaaa ccctgtctct actaaaatac 49620 agaaatgagc tgggcgtggt ggcaggcacc tatagtccca gctacttcga aggctgaggc 49680 agaagaattg cttgaaccca ggaagtggag gttacggtaa gccacaatcg tgccactgca 49740 ctccagcctg ggtgacagag tgagactcca tcacttaata aataaataaa taaataaaat 49800 acagtataac aactatttac ataacatttg cgttgtgtta gctattacaa gtaatctaga 49860 tgtgatttaa aggacatggg aggatgtgtg taggttacat gcaaattcta tgtcatctta 49920 taaagggact tgagcatctg tggattttgg tatgaggtgg tcctggaacc aatcccctac 49980 agatatcaag ggatgactgt atataaagtg attgtgataa gagaaagatt tcctcactgg 50040 ttctgcagtc caactaaact tgcttttcag aaactacgca tgctaccatc tgtctttgat 50100 attctattaa gaaacagagt aaaagactgt aatagaagaa cacataccaa cacatgtact 50160 tacttccttg tggtccataa aacttcacta caaattcatt aagtcctccc aggatcgtaa 50220 cctcatgttt actctcgatg ctaaggtgga cggtaaagga aattacacag gctttacagt 50280 atctggcaga attaccaata acaccccagg catatgccac ttaaagtgtt accaaaattt 50340 ggcatgacat tgataaaata tacataataa ttctggtagt ttaggaggag gcaatatata 50400 ctcttgtaag aagatatgca tgagctttgg attcagagac ggccgttcaa atcccaggaa 50460 tgccatttac tgagtttttg agcctagcca aaataatgtc agtttactcc ctgagtcttt 50520 gttttctctt tgcaaattgg gaaaacagca tttcatagga tttctgtgag gattagacag 50580 gttaaacatg taaaatgtgt aagactgcat tttgcctata tacataaaaa actggccaga 50640 cgcagcggct cacgcctgta atcccaacag tttgagaggc ctaggcgggt ggatcacctg 50700 aggtcaggag ttcgagacca gcgtggccta tatggtgaaa ccccatctct actaaaaaat 50760 acaaaaatta cccaggcatg gtgatgcatg cctgtagtcc cagctactca ggaggccgag 50820 gcaaaagaat tgcttgaagt tgggaggtgg aggttgcagt gagccgagat cacatcactg 50880 cactccagcc tgggtgatag ggtgagactc agtctcaaaa ataaaataaa aaatatacat 50940 gaaaaatagg cgcttaattt tagcttttct ctccctttct accctctcct cctcaatcta 51000 tccctaatga gcctgtcata taaacccagt attcccttta gtcaaattca aatgttcagc 51060 aaaatacaaa ttcccctaaa ctggaaatgc tatgctccta aaacgaggga tttactaagg 51120 agagttccca caattgtctc cttggcttat ggaataatca acacagttaa tgatacaacc 51180 ttgccacaag cagtactgcc aaatgcaaaa gaccaacaaa acaaaaaaaa attttttcag 51240 atcttatcca tagcatctgt tttcactgcc ccccaaactc caccttcttc agacttgcct 51300 caaggtttgg tatgctccag ggctctaatc acagaggggt aacatggctg tgctcccttc 51360 ctctaaaact tacctacccc tgagattctt gcccctttaa ggtgctaaga ttcaattcta 51420 gaaaccaaat taattcatat tagaagagag gactactcgt ttaaaatctg ttctatgtat 51480 ctgctttgcg gtaaaatcca aaaatgattc tcagtaggaa ttttaggtga cagaggcttt 51540 gggaagctct caaatcccac tgtaacatta aaaaggaaaa cacaatagat tggtctcata 51600 tttctccatc agcagtgcaa attatatact gttaatacaa aacagaaaca tttaaaaagt 51660 tttaataatc tcatagagaa taaatatttt taaagatttg aaattaaata tttggcactc 51720 caagcccgtg tccaatgaga cacagaactg actgcaagag gccaggtgta attttggtaa 51780 agtccttgct caagagccct gagtatccac aagagatatt taaataagat agttcagtct 51840 aggctaattt gatctaattc ttttctaaac gataacttac taccttagaa acatgcacac 51900 taaaatgatt caatactgtc cacataggaa aactggcttt atttcttgct tggtcaaatg 51960 acacatgcat gcctactctg accagtcacc ctctgacatc ctgcaaaata ttccaaagtt 52020 aacgttaatg taataagtaa aagcataaca tgcttaaaat gttttaaaac ttttttaaaa 52080 aaagcatcct tgtgtcacgt aaaaaaaggc aaatccagtt aaaataaaat taaatatcaa 52140 caatacagcc cttaaagaaa acagacatgg aaaacacttc catagtgtaa aagacaaatg 52200 ataaactagg aagacaaaaa tgtggatttt aaaaataagt tattacaaag cagcaagaaa 52260 aaaatacaaa taccccaaca aagaaaaagc cagaacatcc aagtcaagaa aacggaaatg 52320 ggtaaaactg aagtataaaa aagtccaatt cattaaagaa gtttaaaaag atatttcttc 52380 actataaaca atgaaaacaa cgaaagagct ggataaaatc tagtgttcag tggagtacga 52440 attagtactt ctgaggacaa atccagcact atattccaaa acttaaaatg aatttactct 52500 tttattcaaa tttcacttat atgaagttat ttttttaaaa atagacactg ctggtgagag 52560 tgtgatatgg tttcacccac tttgaaaaac tgttggcagt actaaacctg cacatatgca 52620 taccctatgc ctgtcagcgc tactcccgga gatacgccca atacatatgg atagttacat 52680 tcaccgaaac cgatgtttaa gaatgttcac aggactattt gtaacatcca aaaattagag 52740 acaatccaaa cgttcatcaa tggcaaaaag aataagctgt agtatagtca cccaaaagaa 52800 aattacaaag cattaaaaaa gaaaaatagg ctgggcacag tggctcacgc ctgtaatccc 52860 agcactgtgg ggagccaggg caggcggatc acttgagatc aggagtttgc gaccagcctg 52920 gccaacatgg cgaaacccta tctctactaa aaacacaaaa attagctggg cgtggtggcg 52980 ggtgcctgta gtcccagcta ttcaggaggc tgaagcagga gaatcgcttg aatccggaag 53040 gcagaagttg cagtgagctg agattgcacc actgtactcc agcctgggca acagagtgag 53100 actccgtctc aaaaaaatat aacttaaaaa aagaaaaaag aatgaattga tacacataat 53160 gtatgggttt tacagatttc atcaatgaac tacaaaaata atttctctac aaaaattagc 53220 caggcatggt ggtatgcgcc tataatccca acaacttggg aggctgaagc aggagaaacg 53280 cttgaaccca ggaggcagag gttgcagtga gccaaaattg caccactgca gtccagcctg 53340 ggtgacagag tgtgactctg tctcaaaaaa ctaaataaaa aaataataaa aatttctgta 53400 ctttggccag gcgcggtggc tcacacctgt aatcccaaca ctttgggggg ccgatgcagg 53460 tggatcacga ggtcaggaga tcgagaccat cctggttaac acggtgaaac cccgtctcta 53520 ctaaaaatac aaaaaattag ccgagcatgg tggcgggtgc ctgtagtccc agctacttgg 53580 gaggctgagg caggagaatg gcatgaacac gggaggtgga gcttgcagtg agccaagaat 53640 gtgccactgc attccagcct gggcgacaga gcaagactcc atctcaaaaa aaaaaaaaaa 53700 aaatttctct actttttgta tatatgttat tctttaataa aaagtttaca aaaataagtg 53760 tttctgataa atctgcatat atgtttcctg gaatatttga agtttaaaaa tggaaacggt 53820 ctaaacattt atcaataaga aactggttca acgaattact attttttttt tttttttttg 53880 agatagggtc tcactctgtc attcaggcta cagtgcagta gcatgatcac ggctcactgc 53940 agtctctacc tcccagtgat cctcccacct ctacttcccc ctagctgggc ctacagcagg 54000 caccaccaca cccagctaat ttttttagtt tttgtagaga cagggtctct ctctttgccc 54060 atgctggtct tgaactcttg ggctcaagtg atcctcccac ctcggcttcc cagagtgctg 54120 ggattatagg cgtgagccac catgcctagc caggtgaaat gacttataag ccatttatac 54180 aataggtggc tggctgcact ggctcatgcc tataatccca gcactttgga aggcctaagg 54240 caggaagatt gtttgagcct aggagtttga ggctgcagtg agctatgatt gtgccactcc 54300 actccagcct gagagagaga gaacttctct taaaaaaaaa aaaaggcaaa aaacacaaac 54360 cacatgcagt aggctactaa tagtgtgtac tggtgtcctc tttccaacca gagctccact 54420 aatatatgtg tctgttcaac ttgggtatcc agaagaagtc aactgaattt agttgtacaa 54480 agatattcca gcccttaaaa ctgacaagga taatgaaaga acggagtagt gcagaagatt 54540 aaacgagttt aacaaaagaa gtcttaaatt aattttataa cataaaaatc cacagatgca 54600 gcattctcca tcaatcagaa ctaatttgct atgaatgaca ctgatctact gcaattactt 54660 ttaatcattt aaaattacga gttgtccttg tggatgttgc ttctgggaaa actgaagata 54720 ccttttctat cctttacctg gatgcgataa aacgaggttc cttccatttt gcggtttgtt 54780 tggaattcag tccatactta cgtgtatttt ataaagaaga tcctccaagc cttctctttc 54840 ccatgatccc cagtaatagc ccacatgcca gctacaatgg gattgtcttt aattatatat 54900 cacatcataa attaaagagt tctcatagtc tacctcatat gaaaacccaa aagcaaactg 54960 aactaaacct ttaaaacttt taccaaacca gtaaaatgag aagctatgct aactttatgc 55020 tgccttggaa tggacaggca ctaaatgaga tagaaaaaag aatttaggtt tagtccaaag 55080 aaaaacactg cattaaaaat aagccattcc atcaccactg aatgaatgac ttgccacaaa 55140 atatataata attacttcac tgctgttacc acgtgtattt atgggagaga ccacgagttt 55200 ctttctcctc tctgctgcaa agtcaagggc aaggaaggca ctaagaaggc aggttaaaat 55260 gacaaaaata atgatcgatt tctggatgtg ctggtcaggc tgggagactg gtgggactca 55320 ctagaagatt cctcattact ttctctgttt cacagcttaa aaatataaaa tatccttcag 55380 acattgttct ggtaaaaact cattaaataa acccataaat cacattttat actcatcttt 55440 tttgatctta ttcacaaata ctgctttata cccacttagc atttcactat taaggggtat 55500 caccattttg tgtagaataa tgattaacat tcccaagaac ccaagtccat ttcacttttt 55560 aaagtgccag ccacctacca cattattttc ctggaatgcc attatgatta cacaatctaa 55620 tatttaaagg caaatgccaa actgtcaaga gataaatgac attcttggca aaatgtgtct 55680 gtcagagttt tacaagtgat ttttatacag ttctgaaatt ttccagaaag gaagccaaag 55740 gcaatgtctg ggccttaagg actgacaata acaggtcaag gaccaaggat tcagggacca 55800 ctgagtccta aatttactga taacaagttc ataaaataaa agagtgccct ccctgagctg 55860 tgtggaaggg aatgaggtcc tggcataaag aacgcgcttc tgtgcagagg gcagaagcaa 55920 gtcgtgtgga tttctgtgtt cagacccacc tgcttcctac tctcctggag atgagtcaca 55980 ctaggaaagc tgaagaaact tggcaatttt cactacctgg ttttttgttt tttggtaaaa 56040 aaaaaaaaaa aaaaaaaaaa aagatatgtc tgttaatcca ttaatatgta agtatcacaa 56100 aaatagtgct ttggggggga tatgtttaca aggaatcctt ctcttttaga gacataaatg 56160 gaaatattta ctaataaaaa tgtttctagg atttgctagt aaataaccca gtgtgggtag 56220 aagaggtgta gaagaaacag tagagggcca gcaacgttaa tgattgaatc ctatgttaat 56280 gatcgagtcc cagcggcaca tgatttgtta cactgttctc actatttttg ttttacattt 56340 aagttttcca taatacagta aaagttcttt aaaacctaat aacatagtta tcatcaaaag 56400 tttagctttg tagaggcata aagcttagct actagagcta agaacaagaa ctagaactag 56460 aatttagcta ctagagctct cttgaacttt tttttttttt ttttttttga gatggagtct 56520 tgctctgcca cccaggctgg agtgcagtcg cacgatctca gctcaccaca acctcggcct 56580 cccaggttca agcgattctc ctgcctcagt ctcccgagta gctgggatta caggtgcaca 56640 ccaccacacc cggctaattt ttgtattttt agtagagacg gggtttcacc atgttggtca 56700 agctggtctt gaattcctga ccttgtgatc cacctgcctc agcctcccaa agtgttggga 56760 ttatgggagt gagccaccac gcccagctaa aggtgatact attaatgagg cccatgcctg 56820 gcctctcttg aacatttatg aaacaatgtt aagttttcct gaggtgcgac agtttgaaga 56880 agacaaaaaa tagcaagtga tccagtattt aagaaagcaa agactggctg ggtgaggtgg 56940 ctcacacctc ctgaggtcgg gagtttgaga ccagcctgac cagcatggag aaaccccgtc 57000 cctactaaaa atacgaaatt agccaggcgt tgtggcacat gcctgtaatc ccagctactc 57060 gggaggcgga gattacggtg agccaaagtt acggtgagct gagatcacac cattgcactc 57120 cagcctgggc aacaagaatg aaactccgtc tcaaaaaaca aaacaaaaca aaagcaaaaa 57180 caaaaaaacc aaagacttta cattgaaaga gaagcatact ctgctaacat tctgaaggaa 57240 acaagttcaa gtggtttcat aaggatgtct atgaaaaata caatcacatg gaaggaagac 57300 aagcatgtgt ctgtatatcc atgacaaaca gcctctaggc aacatgctaa ccaaagctct 57360 taaactacaa ggaaaaatgg tcatgtccaa cagaaaggct cctgattgaa ataagaagct 57420 gaaaaaattt ttaagggttt ttaatgttct tcaaatgaag agggggaagc cttttattca 57480 aaagagaaat tgaatggcag aaataaaagc tattcagaaa atgagcatta tcttgggaaa 57540 ggtttgctaa gtaaagaaaa aaagaaaagt ggcattgaga aaagacaatg ggaagtgggc 57600 tgctatcagt gatgaaatcc atatgtataa agatttaggg accattgcag tggctcacaa 57660 ctgttatcct agcacttcag gaggctgagg tgggaggatt gttttgagcc caggagtttg 57720 agaccagcct gggcaacata gcaagaccct tttttttttt tgagacggag tctcactctg 57780 tcgccaaggc tggagtgcag tggcctgatc tcagctcact gcaatctccg cctcccaggt 57840 tcaagccatt ctcctgcctc ggcctcccga gtagctggga ttacaggcgc ctggcaccac 57900 acctggctaa tttttgtatt ttcagtagag acggagtttc accatattgg ccaggctggt 57960 cttgaactcc tgacctcaag tgatccgttc gcctcagcct cccaaagtgc tagggttata 58020 ggcatgagcc accacgccca gccacaaaaa ctactcttac acagagactg ccttccagaa 58080 gtttgaagtc tagcaaggga acacgagatc tgttcattaa gaagtacaga aagagtttgc 58140 ataaagtaat actatagctt agagtaggag agatttcttc cagcccggag ggagggatag 58200 ggatggtctg ctatggaagg taaggactta caaaatgtcc taaacagagt gtgatttgga 58260 catgtcgagg tgggagaagg aatttaatgc aaagatttag tatagaactg attcaggaaa 58320 ctgagaacaa tacattttta ttttgatgag tggaccctag ggaatactag aaagtaggcc 58380 aagaccagat tacggagggc tccgaagtgt ggattttatc tggcaaacag ggaaacagta 58440 ttccatgcac agtgcatcta cctgtgcttt acaaagataa cccaactgtg gtgtgtagga 58500 ctggctgaag gtgggaataa gcagagttaa agcaaaagag taggaaagaa atattcaaga 58560 cctcaactaa gataacagcc acatgaatca tgggacatta aacagagccc tcacaggcct 58620 tcacagctga acagacctgg cagagccagt agaaagctcc aacgttgcta caatgtctaa 58680 ttttcatgac aaaacaaaaa agcagatctc caaatcaatc ttctaatttc taattcaagc 58740 tctaaatttc taagtgtaaa caaagtatat gtgctccaat gtctccctct cagtgaggcc 58800 ttctgggata tcctatttac aaccacttac tcctaacatt cccaccatgc aatatactat 58860 gtattttact tttatctcct actgcagtgc aagctccgta agagcaggaa ttgtttattt 58920 tgttcacaga agagtaccca gcaaacagta gactacaaat gaacatgagg ccgggtgtag 58980 tggttcatac ctatttaatc ccaacacttt gggaagcaag ggcagaaaga ttgcttgagg 59040 ccaggagtcc gagaccagcc tgggcaacat aacaaaaccc agtctccaca aaaacaaaat 59100 ttttaaacat tagccaggta tggtggtacg tgcttatact cctagctaat cggaaggctg 59160 acaggggagg atcacatgag cccaggagtt aagttagaga ccagcatggg caacatagtg 59220 agacccccat cactacaaaa aacaccaaaa aattagctgg gcagggtggt acgagcctgt 59280 agtcccagct actttgacgg ctgaggcaag aggattgctg gagcccagga gtttgagtct 59340 gtagtaagct atgatgacac tactgaactc cagcctgggt gacaaacata gaccctgtag 59400 cttaaaaaca aataaattta aaaataagat gaacacatga atgaagttgc cagtctgaga 59460 ccttaatttt agcctctcag acaggtaaag tgataccaca tatatatata cacacgtata 59520 catacacacg tatatataca cacgtatata tatacacgtg tatatgtata catacgtgta 59580 tatatgtatg tatatatacg tgtgtatata tatgtatgta tatatacaca tatatataca 59640 cacacttata tatatatttt ttttaaagat ggagttttgc tcttgttgcc caggctagaa 59700 tgcaatggtg tggtctcggc tccctacaac ctccgcctcc caggttgaag cgattctcct 59760 gcctcagcct cccaagcagc cgggattaca ggtgcctgcc accatgcatg gctaattttt 59820 gtatttttag atttttgtat ttcaccatgt tggccaggct gggattgaac tcctgacctc 59880 aggtgatccg cctaccttgg cctcccaaaa tactacaggc gtgagccact gcgcccagcc 59940 aacggtgata ctattaatgg caaagtgaaa cacaggacag caggaatcag ttttgtaatg 60000 aaagacacta ttagtaagtt tacttttgaa aacactaaat ttgaggttat cagtggataa 60060 accaagtggc aatatattat aaacagctgg aaaactcatg acttaaagaa gtcaacttat 60120 aggctgggca tggtggctca cgcctgtaat cccagcactt tgggaggcca aggcgggtgg 60180 atcacaaggt caggagtttg agaccagcct ggccaaaata gtgaaacccc gtctctacta 60240 aaaatacaaa acaaattagc tgggcgtggt ggcgggcgct tgtaatccca gctacttggg 60300 aggctgaggc aggagaatgg cttgaacccg ggaggtggag gttgcggtga gccgagattg 60360 tgccactgcc ctccagcctg ggtgacagag caagactctc tcaaaaaaaa aaatagtcaa 60420 cttataaatc aattaaatct gagcctcttt tttaattttt tatttttttt tgagacggag 60480 tttcactctt gttgcccagg ctggagtgca atggtgccat cttggctcac cgcaacctct 60540 gcctccccag ttcaagagag tctcctgcct caacctccta tatagctggg attacaggca 60600 tgcgccaccg cacctggcta aatctgagcc tgtttcttaa tctctaaaca aagggggagg 60660 ggatgcaggg aagggacatt acctcactca cagaattgtg gaaaattaaa tgaaatactg 60720 tatatccaaa ggtaccaggc ccagcagctg acacaacagg aacttaattt ttttaatgta 60780 aaaataaata ggccgggcat ggtagctcac gcctataatc ccagcacttt gggaggccaa 60840 ggtgggcgga tcatgaggtc aggagttcaa gaccagcctg gccaacatgg tgaaacccca 60900 cctctagtaa aaatgcaaac attagctggg catggtggca cgtgcctgta atcccagcta 60960 cttgggaggc taacacagta gaactgcttg aacagggagg cagagattgc agtgagccga 61020 gatcatgcca ttgtactcag cctgggttac agagcgagat tgtctccaaa aacaaaaaca 61080 aaaaaaaaaa aaaaaacaca cacacacttt acctaaatga attgccacaa aactaaaatt 61140 caaagtttat aaatgtagtg tgtgtgtgtg ttagtttttt tcctacattc ttaagcagaa 61200 tactaaaaaa acatgctaca cctttttttt tttttttttg agacggagtc ttgctttgtt 61260 gcccagactg gagtgtaggg gtgtgatctg ggctcactgc aagctccgcc tcccaggttc 61320 acgccatcct cctgcctcag cctcccaagc agctgggact acaggcgccc gccaccaggc 61380 caagctaatt ttttgtattt ttggtagaga cggggtttca ccgtagccag gatggtctca 61440 atctcctgat ctcgtgatcc gcccgcctcg gcctcccaaa atgctgggat tataggcatg 61500 agccaccgca cccggcctca acctttcttt tttttttgag atggagtctt gctcccatcg 61560 cacaggctgg tgtgcggtag cacaatcttg gctcactgaa acctccacct cctgggttca 61620 agcgattctc cttcctcagc ctcctgagta gctgggatta caggtgcaca ccaccacgcc 61680 cggctaattt ttgtattttt agtagagaca gggttttgcc atattgtcca ggctggtctc 61740 aaactcttga cctcaggtga tccacccacc tcggcctccc aaagtgctgg gattacaggt 61800 atgacccacc gcatccagcc aactacaccc tttcttgatg ctgggtcatc attatgaata 61860 atagttgcta tactgtacta caaaatacaa ggataccctt aggaacaaat aaggaatata 61920 cttatttttt gctgtagaaa atttcccata ctgttatgct aaagtccttg cattgagagg 61980 ttcttttcct agtttctctt tgttcttaac ctttagctat gtttgggaga tgacactggg 62040 ctactatcct ttaaaatgta tctatagtag gctagaaaaa tcagataact gaagttcatg 62100 agattacttt atgtttaaaa aaaaaagggt aaatatgtcc taagaaagac actctccaat 62160 caataaaata tgtaactttt agcaggttta caactaaatt agttggctaa agctgtcaaa 62220 cagcttctga ataagggaag tatcacttat ttaaaaatag ccatttcaaa ataaatatgt 62280 attgcccaga agcaaaaaaa tatctggcaa cttactatgg taccctgaat atttaaagac 62340 ccattatctt aggagtaaag agtaacatac agttttaaaa ttttacagag tcaactggta 62400 cgagtaaggt taaatggcaa gcatgttcat taccacctag cagactaaat cagtctagcc 62460 ttaggagagg aaatttttct tctctagtgt tatgcttcat ttagagtttc tatgtcacaa 62520 gccaaacata ggcaaaaacc aagtaaatgt tacttaaata ggaaaatcat cactataact 62580 tggcttttcc ctgaatgtat tattcctcca gacttccaaa taatagagta aaaaattttc 62640 aaagaaaaat taagactcat agaaacattt taagacaggt ttatcagaaa gataagaaat 62700 ctaagtacca cacccccatc cccaacaaaa tatttttaaa agcagattta caaagtcaga 62760 tagtcaaagt cagaaatgat ccaactgcag aaacagtttc agagagagaa aagtgaaggg 62820 aaatagggaa aaataatgat accatcttga gagcaaggaa atatagtcaa aacaaaaaat 62880 aagattttga gagaaattcc aacttcagtt acgcacttta aaatatttag aagctagaag 62940 gctatcgatg aaatatcaat agctccttaa taaacaaact tgactgcttt gctgttttat 63000 ggcaatagtg catatttgct tacttgcaac tgaaaattac aaatttacat aatgtacaaa 63060 tgcatgtata taaattagca gtatattagc taaatagtat attactctct taactcctaa 63120 agggttaatc aaaagcctac ttttgggcct ggcacagtag ttcacacctg tactcccggc 63180 actttgggag gccgaggcag gtggatcacc tgaggtcagg agttcaagac tagcctgaca 63240 tggcaaaacc ctgtctctac taaaaataca aaaatgagca gggcatggag gcacacacct 63300 ataatcccag ctacttggga ggctgaggca ggagaactgc ttgagcctgg gaggcagagg 63360 ttgtggtgag ctgagatcgt gccactgcac tccagtctgg caacagagac tctgtctcaa 63420 aaaaataaaa taataaatgg gaccaggtgc agtggctcac gcctgtaatt ccaacatttt 63480 aggaggtgaa agcaggcaga tcttttgagc ttagaactct gataccagct tgggcaatat 63540 ggtgaaacac catctctaca aaaaataaaa aaattagctg ggcatggtgg catgcgcctg 63600 tagtcccagc tactcgggag gatcgcttga gcccaggagg tcaaggttgc agtgaaccat 63660 gtcacgccac tgcactccag cctgagcaac agaacaagac cttgtctcta aataaataaa 63720 tgatgtgctt ttgtttcata tctaatccca tctttttttt tttttttttt ttgagacgga 63780 gtttttgctc ttgttgccca agctggagtg caatggcatg atcttggccc actgcaacct 63840 ccacctcccg ggttcaagtg attctcctgc ctcagcctcc cgagtagctg ggattacagg 63900 cacacaccac catacccggc taattttttg tatttttagt agagatgggg tttcaccatg 63960 ttggccaggc tggtctcaaa ctcctgacct caggtgatcc actggcctca gcctcccaaa 64020 gtgctggcat tacaggcctg agccaccgcg cccggcccat acccatcatt tttttttttt 64080 aacttctttt ctcaaagtac atcctacttc tatggaaaga ttgacactca ctgtcaaata 64140 accatcagct agtcaagcat tcagtttaaa atctgcaaac ttggactgaa ccgcagagaa 64200 taaagtcctg caagattctc aagacatgag acacttcaga gatattaaca agtccacaat 64260 gaaattccaa atctagaaaa attgttttaa aaactttttg gaaaactttt agaaggtagg 64320 accttaaaag acatctggta cttaattaaa atccactttt tctgctctca ggaaattata 64380 aaataattag acaacaaaaa tctttcctgg ttaactgtag gcctggaggc aaacaatgag 64440 ctgtgcatct gacatgctgt gcagaagtcc caagtggcat ttagttatgg ctgtcacaca 64500 gtctctagca cctgtcacat gggggctatg gcatgaaggg aagcacaggc ggaagaccta 64560 gacctgcaaa ttctaagggt ggaggggaga cgaaaccatt gcgcacatga gaaaaacatg 64620 caggaagaac cttgtcattc caaaggcaga acctacctaa tcacaggagg ctggcaagac 64680 aaggaaaaca aatcacaacc ttaaaaatga caatagcaac tcaccttgaa aacttccaag 64740 tcataggcaa catataattt ccccgtaaat gatacaaaga catacaaata atcaggtggc 64800 cctctgcaaa atcctaatga aaacatctat ttatttcttc cccccaactc cctctcccca 64860 aaatatctat ttaaaaacat cctactaggc caggcacggt ggctcacacc tgtaatcgca 64920 gcactttggg aggtcaaggc gggtggatca cgaggtcagg agatcgagac catcctggct 64980 aacacagtga aaccccgtct ctactaaaaa tacaaaaaaa ttagccgggt gcctgtagtc 65040 ccaactactt gggaggctga ggcaggagaa tggcgtggag cttgcagtga gttgagatcg 65100 cgccactgca ctccagcctg ggcaacaaag caagactctg tctcagaaaa aaacaacaga 65160 aaaaatccta cttccccttt tgggcggtat gtgtctttgc tataccactc aaagtgctca 65220 acacaaagca acttctcaat aaaaagctaa atttaatatg actttatgga gtatctatgt 65280 agtgcctttg gtattcaagt ttccagtgtt ctttgaaaaa tcttggctgg gcgtcgtggc 65340 tcatgcctgt aatcccagca cttcgggatt caaggcaggt agatcatctg aggttaggag 65400 ttcaagacca gcctccaatg tggcgaaacc ccgtctctac taaaaaacac aaaaaattag 65460 ctggacgtgg tggcgggcat ctgtaatccc agctactcta gaggctgagg caggagaatc 65520 gcttgaatct aggaggcaga cgttgcagtg agccgagatc acaccactgc acaccagcct 65580 gggtaacaga gtgagactcc gtctcaaaaa aaaaacaaaa tctttaagaa cactgcttcc 65640 atttttcatt ttattttcat tgtatttatt tatttactga ttgattgaaa cagggtctca 65700 ctctgttgcc caggctggag tccagtggcg agatcccggc tcagctcacg gcagcctcga 65760 ccctcccagg ttcaaatgat cctcccacct cacccacccc agtagcttgg attacaggca 65820 tgcatcagca catccggctc attttttatt ttttgtatag atgaggtctc cttatgttgc 65880 ccagactagt ctcaatctac tggtctcgag tgatccttct acctcaggct cccaaagtgc 65940 tgggattata ggtgtgagtc accttgcctg gcccttttct gtttttccat tttaaataca 66000 gtttttactc taacttgaca tatagactgc aatgccactc aatgaagata gcatttagct 66060 aagtcagtgc acaaaaatct ctattcacag accttttaat caggcattta tgaatcattc 66120 acagtaagca gttaaatttt acgaggaaat attttctttg gcattcttca tagtgacaaa 66180 tagttacctc tgtagagtgg tgggtgataa ttaataaata ccaagctgcg gtacccattc 66240 agcagataaa gatgatcaaa gtgtgaataa tggatcataa aaaatgtgca ggaagagatg 66300 ccagatatgc catcatcccc ttcctcttac attacattca gcgcacccca aagtcatgga 66360 gccacttact cgaagaccca ggtccacaaa ccagaccatg cctcatcttc ctttccttcc 66420 ctacactgga taattaccag tttatgtctc tagagattga ttccccatct taatgacttc 66480 tataatataa tctcaagaaa attcttgaaa ctcaaatacc tataaatcca gaggaaaaag 66540 gaaaaggtaa cacatatgca catataaata atgaatttgc tcttataaag aggttagaac 66600 ccactagtct aaagctctaa tcatagtctg ctcgttctcc agttatcttg cataatatga 66660 atggctgacc cctgctgctc cctttactac ttcaagttca ttaggcatag caggtgtcaa 66720 atattaagtg gcactaatat caatttaacc ttgatttcat aaaacttaaa aaggggaaga 66780 gaatactaga cttcggcctt tttaaagcaa tacatgcaaa aagaaataaa gtaacaggtt 66840 caaaattact gtcaaggttt tattctgaaa aaagcaaaac tacagatgga tacactagac 66900 agaatgctaa atgcaatcta catgcagaga actctgcgtt ccaaaacaaa tgaatatggc 66960 tttattcaac tgggcccagt ttccattgtc cctttggaag atttatgaga ggcagtaccc 67020 attatctgtt ggaagtttga taaaaacttg tataaacagt gtttaaaaaa atcaaaaagt 67080 aatctaaaga gatatagaaa aatagtgtct tcttgattga aattctgctt aaaaactata 67140 cagaagtgta gttaacagga aaatacctta tttgataata cgttcaaata gctattataa 67200 gctgcctgta tttattatct ttatcaacat ttaggatgaa agaagtggga taaaaaactt 67260 tcaacaaaaa ctggaatgct gctttttaaa aaaacccata gtgaaaataa gcaaaagaaa 67320 tgaattattt tatggaaaaa aattgctgtt aaagaaacac cctaccataa gaaaatcaca 67380 ccaatatgag taaataagca agaaaaccct ggaaagtcaa gggaggtgaa agtagactgt 67440 atctaggtgt gcaatgtgat acaacaagag tggtagagct attttcagca tcatactact 67500 aacaggtgat agatctcaga gaaaaagcca ccctgccata ttagcaaaac tgctagctca 67560 agaccaacag aaatgattaa catacagtta agaaatgatc tgtcaggtac aattaggaca 67620 tatgaagtga taaacagtat aaaagaaacc aacctaatca cttaagtaga agtttagatt 67680 taaatatgca tcaacaataa gaatgaaggc tgtattgtta tgaagtatga gaaggaaatt 67740 aaaaatcaag tttctcacaa ggagtagtac ttcctgaaga actgaataat atgaaaaaaa 67800 tcaagctatt tagcaaaaca acagaaaaca aacctagaca caacagtgga tgtatatata 67860 gtaagaaaac ttgacattga aaaggtgaaa aaactattga gtttccttct ctcgtgtttg 67920 caccacggag acaagtagaa ctgataggct caggtgccac catgtgagat gtgctggtgc 67980 aatcagaggg cacagtgcag aggagaatcc ctcctgaaag acacaagagc accctcaata 68040 caaccaaata acctcatcag atcaagtgtt gagttgcagg cctttttttt tttttcttgt 68100 cttttaaaaa catgactggg gcttaaaata gcctttccac cccgcaactt ctagtcccac 68160 tgcctagata ctaccattgc ttatgcactt tccatagaga tgtttatata cacacacatc 68220 cacgtcatca catacacaaa gacatgtagg tacaaactgt tctgtaaata cctctgccca 68280 tgcatctagg gaggatatgt ttgaggacat atagatctaa gctccttttt ttagtgcttg 68340 tataatgtca atataccata atttacctat ccgtaatttc atatccatta gtgaatagga 68400 aggctgttgt ctgctgtttg ttttgttttg ttttgctatt agttacaata aacatcccag 68460 tacatgtctg ttggtatact ttttcaagta tctgtttgca atttctagaa gtggaacttc 68520 tattcaaagg gctgtatacc taattttgac atataatgct taaatatcct tcaaaaaggt 68580 tgcatccagt tactttctaa ctaccatcac ctaagcagac ctgtttccct catgctctca 68640 ccaataccag tattaaagct tttatagtaa aataaagttc acctttaaac accacctcaa 68700 ttgccaaacg cagctcaaat tgtccagtgc ttttttttct ctcatgctgt tcaccaatcc 68760 aacagagccc tggctaggtg acccatgggg aaaagcatgc ttttcacagg gattcgctct 68820 actgttcctt cttgcctctt taacacaaca cgtgcatgtg ctcaggattc acgaacaaaa 68880 acttactaag atatgaagca cctttcatca actatctcaa agagaaggct aatcaattaa 68940 atctcaccta acgtgtgaga caggttaact ccagaacctg atcagaaaaa aacaaaaaca 69000 aggacagagt ttagtctgat acggcatcac ttaatcaaac aacaaggagt agtattttac 69060 ctacatctca aacacttaaa aagtatttgt acttctaaat ctgtgccccc acagggctgg 69120 acaccatggc tcacacctgt aaatccagca ctttgggagg ccgaggcagg cagatcactt 69180 gaggtgagga gtacgagacc agcctagcca atatggcaaa accccgtctc tctactaaaa 69240 atacaaaaac tagccaggtg tggtggcaca caactgtaac cccagctact cgagaggctg 69300 aggcaggaga atcgcttgaa catgggaagt ggagactgca gtgacccgag atcacatcac 69360 tgcactccag cctgggctac agagtaagac ccatctcaaa aaaaaaaaaa aattaaaata 69420 ataaaataaa tctatgccca aaataggata tgaagttaac ttcttatttc ttaggtggac 69480 ctgatacgtc aaatagctcc ttattccaaa ctactgtgct attacagcat gcaaaataat 69540 gtgttctcac aaaagaatga catggattta attatctcaa catccaacat taatgtaaca 69600 catatgttac tctccaattt gctaaaagcc atagagttta cccttgacta cttaaatgtg 69660 agatcccata gaagataatt caaacacatg gaagataatt cattgtatct atataacatt 69720 tgtatatact atttgatttt atagtttcga atattatcaa atgactttct cacattggag 69780 tatcaggatt ttcaacctca cccccatgtt tcttcttcct ctccatggaa tacaatcaca 69840 tcaccattgt tggccaaatc actatttaga gattatatta tgaccatgta aatttttttt 69900 tattatactt taagttttag ggtacatgtg cacattgtgc aggttagtta catacgtata 69960 catgtaaata ttattcactt ctgagccata tagcatcgta tgattaagat ttctttttcc 70020 tttttttttt tttttttgag acagagtctc actctgtcac ccaggctgga gtgcagtggc 70080 accatctcca ctcactgcaa gctccacctc ccaggttcac accattctcc tgcctcagcc 70140 tcctgagtag ctgggactac aggtgcccac caccacgccc ggctaatttt ttgtattttt 70200 agtagagaag gggtttcacc gtgttagcca ggatggtctc catctcctga cctcatgatc 70260 cactcgcctt ggcctcccaa agtgctggga ttaacaggcg tgactcaccg taccaggtgt 70320 tttctttttc tttacagtat ttttccccaa ggaaataagc actgtcttaa acactaaatt 70380 aataagaaac caatgtatct atccttaatt tgttcctcac ctcagacaga actgtctcaa 70440 catgtttaaa cacatcaaga tgagtatttg tatttaaatg ttttccctag caaatgtacc 70500 tttctcatta tttgtggctg gtgagttgtg gagggaggac aggagcccag gcagtctagt 70560 tcaagtctgt tctttgagcc accctatttg cctctctcta tcaagaccac agggcttctg 70620 gagaggagtg tggcacactc aggcttgttc tgatgaggaa ggtgaccaac agcgagactg 70680 cacagcgcca cagggagatg ctggtgggat agaggtcggt gggggctaat gcacagacag 70740 gtaagtactg ataggcagta gactggctgg aggggaagcc acatttcaac gagattttga 70800 agaactggat gactaactgt atatgaggga gaagaaagac tcaagaatat ctgatatttc 70860 caatctagta gatgatgaca ctttcttttt ttgagatctt cttacccagg ctggagtgca 70920 atgtgtgatc tcagctcact gcaacctctg cctcccgggt tcaagcgatt ctcctgcctc 70980 agcctcctga atagctggga ttacaggtgc ccgccaccat gtctggctaa ttttttgtat 71040 ttttagtaga gatgaggttt caccatgttg gccaggctgg tctcaactct tgacctcaag 71100 taatccaccc acctcagcct cccaaaatgc taggattaca ggtgtgagcc actgcacccg 71160 gctgatgaca ctgttctaac aaaaataaaa ggcaggcagg agtagcagaa gcaagtttgg 71220 tgggggagcg ggggagagag aagaacaatg tggagtattt aacatgatga gacaacaagt 71280 aattgtccaa cagacaacat taagtgttat taacccgttt tcacttagtc ctacttcttt 71340 caaagtagat ctttaaaacg ggaactcagc atacaaagag ttctaagaaa aggctgagca 71400 aatgaataaa aaaatgtaac tttagatctt agtaatctaa ggaatcatta aactacatat 71460 aagtctctta acaaaaccat tacatggccg ggcacggtgg ctcacagctg taatctcagc 71520 actttgggag gccgaggcgg atggatcacc tgaggtcagg agttcaagac cagcctggcc 71580 aatatggcaa aaccccgtct ctactaaaaa tacaaaaaaa ttagctgggc atggtggcag 71640 gcagctgcaa tcctagctac ttgggaggct gaggcaggag aatcgcttgg acctgggagg 71700 cggaggttgc agtgagccga gatgcaccat tgcactccag cctgggcgac agagcgagac 71760 tccatctcaa acaaacaaaa aacctgttgc acaagtgaga ataagggagg ctccatggga 71820 cgggggaagg ctttggagta gagcaaacct gggtttgagg cccatctccc ccatttccta 71880 ggaagtagcc tacagcctcc tatttaaggt ggaggagctt gttagaaatg aacacactgg 71940 accccagttt cagactaact gaatcaaaat ctccatttta acaagagtcc ccagtaactg 72000 agaagcacca gcctaaggca agtgaaatga tctctaagcc ttgcctcccc ccaccattta 72060 caaaagtggg gataagcata tttaccctac ggggaaactg aggattaaca ggtgccaaat 72120 atttaccaag cctctatcaa gaggtgttag tgtcttacat atgttacatc gtttaatcct 72180 ctcaacaacc ctatcatgca agtattgttt ccattataaa aaatgaatac actgtcgggc 72240 tgcaaccccg tccaaggtcg gactgctatt gagtcgtaga gctgctactc actgtggctc 72300 cctgctctgc atttggcttc ccattaacct caataatgca tatgcaacct agtgcagcca 72360 agggcacaga atgtgtgaga gcaagggagg aaagaagcct tgcacctaca gagaatctaa 72420 acactagttt aaagcacaat ccacaaagtt caaaaactgt actcatataa gcttaaatga 72480 ctcagctgtg cttatccttg aactgatttt cagataagga tgtggcatta aatgaacagt 72540 atttatttca acagttgtgc taaaatagat caaccagcag aatgcaacga cggttaataa 72600 gactatgtga aaattctcaa taagacacag aaaactctca atatagcttt attccaggct 72660 cctgagggat aggaattcag acaagaaaag gaacatccta agagtgtctg taattgtagg 72720 atatatttca cataaagact gaaattctcg gccaggcata gtggctcatg cctgtaatcc 72780 caacacttta ggagacccag gtgggagaac cacttgaggc caggagtttg agaccagcct 72840 gggcaacaca gcaagacgcc atatctacaa aaattttaaa actatggctg catgtggtgg 72900 ctcacgtctg taatcccagc actttgggaa gccaaggcag gaggactgct tgagcccagg 72960 agtttgagac tagcctacgc aacaaagcaa gacgccatct ctattattta aaaaacaaaa 73020 caaaactagc tgagcacagt gttacacacc tgttatccaa gctactgaga aggctgaaat 73080 gggaggatcc cttgagccca ggagttcaag gctacaggta gctatgctgg catctgtact 73140 ccagcctcgg caatagagtg acaccctgtc tcttaaaaaa taataagttc taggttatct 73200 ttcaatcgtt attttttgag tattaacatt ccagaaaaga atgtgcaaaa ttaacattta 73260 gaatcccaat ttataacagt gctagttcca aacaaatcta aagtatgtga atcactcact 73320 gtatcgacag ctgtctaatt tcactcatcc aagcccacaa tatgcctgac acggtctcag 73380 tctgccacat tcttcctctc ttacctttct agatacactg gtcttctttc atttcctcaa 73440 acacaataag ctctcttcct ccccagggcc tttgcaatgg ctatttcttc tgcccagccc 73500 tgatttccct gttttgacag atagcttgct gattcttatc ctttaaggtg tgtctttttt 73560 ttttttaaat agagatgggg atctcgctgt gttggcgagg ctggtctcaa actcctggcc 73620 ttaagcgatc ctcttgcctt ggccttccaa agtgctggga ttaacagtgt gagccactgc 73680 accaggcctt tatggtgtgt ctaaatggca cttccttaga gacctttccg atcacctgaa 73740 gtacatgccc aacagaccat cccaattatt ctctacctca ttctattgtc tatttccttg 73800 taggttttat catgagtact attttgtctt tttatatcct ccctcacctc gaacgaaatt 73860 cgacttccaa gagggcaaga accttatttg cctttattcc tgacatgtag ctgagtgact 73920 agcctcggct acgtgtcagt ggatgctcaa cagaaactgg ttaaatgaat agtgtgagta 73980 ggtgccaggc actacgctag acagtaggat ctggaaataa gagagcatct gccctctgaa 74040 agctccaagt ttagtgggga aatgaacaat caataaacta ccaaagaggc agttaagagt 74100 gatatgaggg ttactcagca gtgctgaaga ggcacactga aggtgctcct gtcctaatcc 74160 aggaggtggg gaagccaaag gtgttttcaa gaggtggtga tgctggctaa atgcaatggg 74220 agattagcat tttgctctta tatggcagct acagtgaagt tttttccaag gacatgaagt 74280 aagatggccc ctcagagttc aactcgagat caacacacaa tgactgaggg gagtacaagc 74340 catttgaaag agaaaatctg gttttccaca tagcaagatt caagtacagc cagaatcaat 74400 gtattcagac atgcaaagga ttaaggtatc tcataaaagg gtcacccctg caagctcaga 74460 agaagaatga aaaagaaaga ctggcagggg ccactgaagc aactagatag gggagaaaag 74520 gagtctttgt tcatagacat gaggtttctg gtcacaacag atctacgatg agatggtggt 74580 atcatcagat tgtgtcagac cattatacat ttgattcatc tcattgtttt tgttctaatg 74640 ccttctcgaa taaccttctt tccaatgata gtatgggatc ccagctatgt ttacctatag 74700 agaccagaaa cactggtaca caattaaaat tatatgctgg ttttccagtt gtacctttca 74760 gacttatgag cttggttcat ctgatgccat ggaagtagat ctgctcttag tacacaaatt 74820 agatgcttgg aaggcagggg agtccccttc ccaacaaagg ataaggttgg ccagaactca 74880 aaacagagga ggaaaaggat ttttgtaaga aatgtttgag gtgaacctca cagacacaga 74940 aagagaagga agagggacaa gccaaggatg attccaatgt ttctggcttg agttatctca 75000 agttgagtta tcctggtatt gctgatggta ataccattca gcaatcgagg aataagagag 75060 ggcctaagac ttacagagag gccaggcaca gcggctcacg cctgcagtcc cagctactca 75120 gaaggccaaa gcagaaggat ggtttgagcc caggagccag gagttagagg ttacaatgag 75180 ctatgacagt gccactgtac tccagcctgg gccactgagc gagacactgt ctccaaaaaa 75240 aaaagactta tacagatgtt ccatttagga catgttgaat ctggggtctc tgaaaagcag 75300 caaagagaag atgtccagta ggcatttggc catccaagac cagagctcaa gagatatgga 75360 atttttattc taaaaacaca ttcaggcaat aatagatgaa atcactcaag aatagggtac 75420 taactaccaa gagataagga tgaactgtga aaccccgagt aaagccattt ttttttcttt 75480 cttttttttt ttttgagaca gtcttgctct gttgcccagg ctggagtgca gtggcgccac 75540 cttggctcac tgcaacctcc acctcccggt tcaagcgatt cttgtgcctc agcctcctga 75600 gtagctggga ttacaggtgt gtgccaccac atgcggctaa tttttgtatt tttagtagag 75660 gcagggtttc accatgttgg ccaggctggt ctcgaactcc tggcctcatg tgatccaccc 75720 acatcagcct cccaaagtgc tgggattaca gttgtgagtc acgcgcccag ccctgagtaa 75780 agccagtatt taagagaaga ggaacctaca aggtatcctg agaaacagat aggcatctag 75840 aattaagtta agtatttgtt aggttatcat ttaatgtctg ctttcaacaa gtatgcaatg 75900 tcttacagag aaaattcaag ttttaaaaag aaaaaaaaat ttgcttatag taaagttact 75960 gaaaaagaaa aagttctttc agaataccgt aacatggctt cctgggacag gaaggaaacc 76020 aatgagatac accctcctga cctcttacca gtacttcaaa aagtgcaata aagctggttg 76080 agagaaacaa agaagtttct ttggagacct actttaaacg cttaatccgt gccaaaagtc 76140 caaagtccat gaagctaact acctttggat gaattttcaa ggcagagata aaatctccaa 76200 tgtgcacttt aatgactaat actagttttg agagacatta ctacacatct atgctctggg 76260 acagaccaaa ccttcagtct ctacgtcaat ggtacaacag agtactattc tccccagtag 76320 tgttactgaa tttgcgactc actgagttgg aagagctgct taaaggttta tcatcatcaa 76380 aagccattta ttagggggtg ttcttgtttt tttttgagca aagtgctaaa aactccgttg 76440 tacgtttcct accccatcat agtttacaac tttgttgggt aagatcaaat gactccaaaa 76500 aacacctctg gaatttcaat acaagttgcg atagttaagt gccaaaacaa gcggtatgac 76560 agctgtcggg atgcagaagt aatcagtaaa gcctggatcg tgtaagaaaa tggggcttga 76620 gccagacttt aaggaaaggc caagcagtca agaaggaata tgatgtccaa ggaatatcat 76680 aggcagggta cagctgacag caaaggcaca gatgcagcaa ctgtgcctag aaccagttga 76740 tcagttttat tgcaataaga ggttcatgta gccgggttgt ggtagataaa agcagataag 76800 tagacaaaaa gcaagacggt agagagccag accacagcat tttgtacttt atcctatgaa 76860 cagtacatag ccagtgaagg ttttatgccg aggtagatga cggatgcaaa gcacaatttt 76920 aggaaaatta atctggcaac tgtgtataga aaggttaatg gaatatcatc attgtgacga 76980 ggtatacatg tgtcaaaact catcaaatgt atacacttaa aattgctgaa ttttactgca 77040 tataaattat acctcaggaa gaccaatttt ttcaaaacaa aggacaaaga taaagacaag 77100 aataagcaga ttattaaaat acaggctgga aaaaaagtca ggctgtaaaa tcctgaatat 77160 ttgatagctg agattaattc aagccagctg attatacaca ttttttccca acttcagcaa 77220 cataacacta gtagcctgaa accagccatg atagagtatt tatacctcag aaatcagcaa 77280 acattacaaa tcagggcttt atccccctcc ccagggtggt tgttcaatat tcaccagcac 77340 accactgtgt aatttctata cgaggtttgg cttggatatg gtgctaaatg aagagttcct 77400 cgacatttct tctcactcaa aataatgaca taattccgaa gcaccatatc ttaatcttac 77460 cagcagtaga cagttatcaa aaaagtgtta agatttaaga gtctaacatt ttactagttt 77520 caagaattaa agcatgccca tgaataagaa acctttgtgt ctcccaatca aggtttctag 77580 ctattatgtg gtttgggact aacaccaact gatgatgaca atgcacaaaa aattccacca 77640 ttcattccat tatactaaag gctaattgca tgggcctatt attggaatat gctttcctag 77700 ttcaactagc tgcatttcaa tagagtaaag agggttttct ggagaaaccc tactgtgaaa 77760 agatgaactt tgtcttaaca actttagttt caaaaactat tcatttatag atgcctattt 77820 cacgtctctg aagcaaaatg gttcatttgt tatgtagatt actaagcagt cagtcactta 77880 agaataaaaa gtttcttctt tagaggctcc agctaactgt ctgcataggt tcaatctaaa 77940 aaccagcaaa gcatactgct aaatatgata gcaaataatt gtttaaacac aaatgagcac 78000 caccttcaaa ttttccaatc cactttccaa gggccaatct atgattatcc ccaacaaaga 78060 ctgcctgctc ctgggtttct taccagtaaa gggaagaaat ggggggtcac aagaggggaa 78120 taaggcagga ggtatagaat gatgttctct actgcagatc tgactccatg agtccttaac 78180 taacagcctt aagttttgtt tcaaaagttc ttaagtccat tgcgtagaac tcagaatgta 78240 acttcctaca cacaaaagcc aatttaactc acttttatct gaagtacact atttaactct 78300 ggaatattag ccatcatcta taccaatgct tttactaaaa aaagtaagtg cattcagagt 78360 tttaattgag acactaaaac catcatttga acctcattgc aactggagcc cctctctctc 78420 agagaaggaa tacaaaacac aggagaaaga tcataaagaa ctatgtaata taaggagcag 78480 ggagaaaatg tcaggtggga aaaatggccg gaaatgggaa gaagaaacat gtacaagaat 78540 caccaggaga gtgacattcc ccgccccact gatacctaga gaggggcagg cagggggtag 78600 gtattcatca gacatgcaca ctttgatgaa gcaccccgtg aatttctgac ctacacctca 78660 aagaaccaca gctccaagga gtgagctgca aggccatgaa aaacatacaa ggggacggtt 78720 cagagcccca ggtttgctca ctgagcattc tttctaccag actccagtcc aagggtcttt 78780 tccttttgct tctaattgcc ctggaagagt agaaataaga acccttcaaa aagagaaaaa 78840 tgggccggga gtggtggctc acgcctgtaa tcttagcact ttgggaggct gaggtgggag 78900 gatcacttga ccctaggagt tcaagacctg cctagacaac ataatgagac cctgtctgta 78960 ttaaaaaata tataaatgta catgtggccc cacctcttta gtaataaata tttaccattt 79020 tccactcatt cttcacaatg cttaagccca gacgcaatac aaacagttct aggatctagg 79080 gacaaagaga taagacacag aatctatctt ctaaggagca gcttgaaaga ggtgggagtt 79140 ggagccacaa gcaaacagct gattatataa agtggtctga ggggaaaaca aaggggtcaa 79200 ttaaagcata cagaagacac gaaaagggtt gaaaacaaat atagaggggg ggtgattcaa 79260 ggaaggcttt gagtaagatg caaggcttga ggtgaatatt gaagaataaa caaaagttgc 79320 caggcacggt ggctcgccta taatcccagc actttgggag gctgaagcag gcatatcacc 79380 tgaggtcggg agttcgagac cagtctggcc aacatggcga aaccccatct ctaccaaaaa 79440 tacaaaaatt agccgagtgt ggtggcaggc acctgtaatc ccagctactc aagaggctga 79500 ggcaggagag tcgcttgaac cctggaggtg aaggttacag tgaacggaga ttgcaccact 79560 gcactccagc ctggacaaca gagcaagact ctatctcaaa aaaaaaacaa aaacaaaaac 79620 aaaaaggcca aaagagaaag ggactctgta gaagagttag gaagtgtccc ttgagaaggc 79680 taggggaggg gagaggcata cagcacagca ttgtatcttt gaccgatggt aggaaggcac 79740 tacttctcta tcaaactgac ttttaaacca agactccatc aaaccgattt ttataccaag 79800 gttaggcttt aaaccatggg tgctaaagag caactaagga gttttaggca agaagtagca 79860 taatcagatg tacaaaaaac agtatcatgc ctgtaatccc agcactttgg aaggccgagg 79920 aaggctgatt gtctgaggtc tggagttcaa gaccagcctg gacaacacgg tgaaaccccg 79980 tctctactaa aaatacaaaa attagccagg tgtggtggtg ggcacctata atcccagcta 80040 ctcggaaggc tgaggcagga gaatcacttg aacccgggaa gcggaggttg cagtgagcag 80100 agagcacacc accgtactcc agcctgggtg acagagtaag attccatctc aaaaaacaaa 80160 aacaaaaaca aaacaggatc actctggcag ccaagatgaa aggcagactg gaaggagaca 80220 gactagatgc agggagccct gaagttgtga gattatctcc aacagtccag gtaaggtccc 80280 gaggccctga atcaaacagt ggtggtcgca atggagggca gggttggggg agagaataaa 80340 gaggcagaac aggtcaggca tggtgactca tgcctgtaat cccagcactt tgggaggcca 80400 aggcgcgcag atcacagggt caggaaaatg agaccatcct ggctaacacg gtggaaccct 80460 gtctctacta aaaatacaaa aaaaaagtta gccaggcatg gtggcacaca cctgtagtcc 80520 cagctactca ggaggctgag gcaggagaat tgcttgaacc tgggaggtgg aggttccagt 80580 gagctgagat cacaccattg caccactcca gcctgggtga cagagtgaga ctccgtctca 80640 attaaaaaaa aaaaaaaatg aggacagaac aaacaggatg agggaggttg ttaagacaca 80700 caggtttccc acttcggcaa taggtaagta aacaaaaaaa cagattgtag taagagtttg 80760 gaagaaatag tactgacatc agtattggac atgcaaggtt ttaggggcct gttgggatcg 80820 tcttggagag atatttggaa ggcaggcacc tacactaacc tagagtttag gaaacaacaa 80880 ctcaactaaa aatgcacata tatgtttttt ttaattattt tttagagaca gggtctcact 80940 ctgttgccca ggctggaagg cagtggcatc atcatagctc actgtaacct tgaactcctg 81000 ggttcaagtg atcctcctgc ctcagcctcc cgagtagcta tgggactaca ggtgtgtgcc 81060 accatgcctg gctaattctt aaatttttct ttgtagggac gatgtcttga tatgttgccc 81120 aggctaatct caaactcctg gcctcaagca gtccttctgc ctcggcttcc caaagtgctg 81180 ggattacaga catgagccac cataccgggt ctatgaatca ttttatagca aaggatgtgt 81240 tatgtgaaaa gatgactgag aatgaagcct aagggaaaaa caacctttaa tacatgtaca 81300 cagagagatg caggaccaag gtaggccttt attatgagat agaatttaaa atgttccttc 81360 agtttagggg tccacgaact agggcccacc ccctgttttt gtaaataaag ttttactgga 81420 acacgccatg cccatccatt tacgtattat tgatggctgc ttctgtgctg caacagcaga 81480 gttgaatagt tgcaaaaaag accatacagc ccacaaagcc taaaatattt actacaggct 81540 gagtattctt tatctgaaat gcatgggacc agaaatgttt tggatttatt tgcatataca 81600 taatgacata tcttggcgat gagactcaag tctaaacatg aaattcattt acatttcttt 81660 ctttttaaag agatggggtc tcataatgct gtccaggctg gtctcaaact cctgggcttg 81720 gcgatcctcc cacctcagcc tcccaaagtg ctgggattac atcatgagcc accacactgg 81780 gctcatttat gtttcatata catcttatac acatagtctg aaggtaattt taaacaatat 81840 tttaaataat tctgtacatg aaacaaagtt tgtgttaagt atttatgtgt ggaattttcc 81900 acttgtgtta cgtaggtgct caaaaagttt tgaattttgg agcattttag attttggatt 81960 ttcagataag ggatgcacaa cctgtttttg gcccttataa agcccgctca ctcatacttt 82020 actcaacggc ctttaggcaa agcctatccc tatttcctac ctcagttttt ccatttgaga 82080 aatgaaatgt acactatgtt caagttcaac aagaacttaa aaggctcatt tttaataatt 82140 aatcactaaa aattttcctc aaatattttg ttcaacacaa ccaagtacat ttccaataaa 82200 agtcaaggtt tcaaagaata taaaaatgta caacattggg ccaggtgcgg tggtcacgcc 82260 tgtaatccca gcactttcgg aggccaaggc gggtgggtcg cctgaggtca ggagttcgag 82320 accagcctgg ccaacatagt gaaacctcgt ctctactaaa aatacaaaaa attagctggg 82380 cacggtggcg ggtgcctgta atcccagcta ctcgggaggc tgaggcagga gaatggcttg 82440 aaccccggag gcagaggctg cagtgagccg agatcatgcc actgcactcc agcctgggca 82500 gcaagagcga aactccgtct caaaaaaaaa aaaaaaaaaa gagtacagca cagaatttga 82560 ctatatagga tttaaattac aaggcaattt attgacttac atgtgcctac aaaataaagg 82620 gaatcccaaa ttttacttta tatccaattc agagcattaa cacaacagtc tactccagaa 82680 agcattcacc ttgacctgtt acaaaaggtc ctgatctttt gtaatagaag agaagagcca 82740 cacagcagag aagttattgc tatctccacc accactgcca tcattttctg aacacccgcc 82800 atgtctagat gccattccaa gcatctaagg cctgtatgtt tcattcgagc ccctcaataa 82860 ctcatgagga catccatcca ttttacagat gaggaaactg agcctcagaa gggtaaagag 82920 cctttaactg ggtgcagtgg catgcatctg tagtcccagt tactccagag gctgaggcac 82980 aaggattgct tgagcccagg aattggaggc tgcagtgagc tatgattacg ccactgtact 83040 ccagcctgag caagagccag accctgtctc tcaaggggag aaaatggtta agagccttgc 83100 ctcaagtcat ctagtaggga gcgggtgaca gaaccaagtc tgacctcaga ggctctgtac 83160 ttaactacga ccccatactt ttgttaccga catggaagga gataacactt ataaaagaac 83220 aaatggaatc tggacactag gaaacacata tctgcttgtc ttccccactt ggaactcaat 83280 gcatatcttg gaagccagat tggtgtcagc agcttaagaa ggtaacatgt attgactgta 83340 ccaatgggct ctggccagac agcctcagaa ccacaaccag gtgcaacata gctgccagca 83400 gacaacgtat caagttccca acagccacct caaaaatcaa tttttttttt ttttgagaca 83460 gagtcttgct ctgttgccca ggctggagtg cagaggtgca attttggctc actgcaacct 83520 ccgcctccca ggttcaagcg attctcctgc ctcagcctcc tcagtagctg ggactacagg 83580 agcgccccac catgcctggc taacttttgt attttagtag agatggggtt ttgccatgtt 83640 ggccagggtg gtctcaaact cctgacctca agtgacccac acaccttggc ctcccgaagt 83700 gctgggatta caggcgtgag ccaccatgcc cgaccaaaaa tcaacctttt aaacaactcc 83760 cctccagaaa cagagggaag ccgacacaag aaataaaaag acctttgtaa atcagatatt 83820 acagtaatgt actctaagag gtcatatgat acactcagtg gcaagaacat aagctttcac 83880 ttcaaaccga cccaggtttg agttctggtt tcaacacaag gcttatgaca gtaaattact 83940 tatcttctct gagcccactc ccttgatgaa ataaagaacc acactctctg ccagacagtc 84000 cagggaatta tcagtaccat aatagagaat ttagttgttc agagtcaaag ctcccgagtt 84060 atacagactg agcttatctc tcagctctgc aacttacttg gcatgagata ggggcctaag 84120 gtttcatctt taaaacagaa aaaaagaaaa cagtacctac ctcttgagtt attctgagga 84180 ctgaggaaga tatttaaagt gctaaaaaac acaatgtccg gcccaggatg cgctcaaatg 84240 tcagctgtta ctactatgat taatgtgtct ggcacacagt aagcactcta agaggctttt 84300 cattagtgta agttatagac caaatgacaa cttccaactt caagacctga tctttagggg 84360 aaacaatgtc tttccccgag gctgtgaaat taactttcac agctttaaag gagtggcaga 84420 agcacatttc ctgcaacaaa aaccacgggc ttggctccct cttgttaaat ggtaggaagg 84480 tttcttcacc tgcttcttca cactttattt aaatactaaa tacagccggg cgcggtgtct 84540 cacacctgta atcccagcac tttgagaggt tgagacgggc agatcacgag gtcaggagat 84600 cgagaccatc ctggctaaca cagtggaacc ccgtccacta aaaatacaaa aaattagccg 84660 ggtgtggtgg cgggcacctg tagtcccagc tacttgggag gctgaggcag gagaatggca 84720 tgaacctggg aggcggagtt tgcagtgagc cgagattgcg ccactgcact ccagcctggg 84780 tgacagagcg agactctgtc tcaaaaaaat aaataaatac taaatactac tactggtact 84840 ttcaggcagg caacaccctt aacctctaaa cagaacgaac tattttcccc acatatggtt 84900 ttcagagcac taggaagaaa cactgaaaca gaaaggcatc tgtttagaag cagaacttta 84960 actccttgta aaacagcctg cccgtacctg tggccaaagc aaaagcaaac gggctaagtg 85020 gcccagaccc tcctaactct gcctgtcttt caagagaact cctaccatcc ccagcatgca 85080 gttgcttttg agctcccttt gtatctcaaa atccataaaa atgttgagta ccacagatcg 85140 ttctttcaat catcagttca gaatacagaa acagaccaaa ggcaatgcaa agacaatcta 85200 taatttaaaa attccttgac ctctatctgc ctcgtaagtc catctagcta aaatgtacat 85260 ttcatataaa gttcaattat taaaaagcca gaaaaaatcc ataaaaccct ctgaatctta 85320 gaaagctctc tcagatgcat tttaaatttt caaatagctc acatgcctgc acttgttaac 85380 ttttcgtcaa atgacttcag ctttttttat ataggcaggt aattatattc attccaggac 85440 tttaacatcc taaacacaaa gtttaaccgg cattataacc agcttaacag aaaaatcctc 85500 ttccattaaa cagatccgat tcaaggggta tctaagaaaa acaggaaaac agtttccaga 85560 tacagcactg gcttttatcc accacagaaa tcaacaactc agcttctaca aactttaaca 85620 agtttgcttt aaatttctaa gccatttgaa atagaatatg cacaagtggt taatgatctt 85680 gtattttctt cccacttaaa aaaaaaaaaa gaagccattt atcacactca agttctaaca 85740 attaaaaaaa aaaaaaaaag cctaccaaaa atcaaatccc aaaccacagc catcctctcc 85800 agaactttgc aacagtctag ttcacatcta caagccttac ttttgtttgg aaagctaggg 85860 ggaaggaaag cagcctgttt tagatttcat ttctagggaa atagaaatag acgcaaagcc 85920 tcaaggttac acagtacaca cagagaacat cctgtccact agcctaaaca cactctaagc 85980 atgtacacgg ctaatggcca aaccacctgc aaaagttcca tttgcggctg ggagcggtgg 86040 ctcacacctg taattccagc actttgggag gccaagaagg gggatcaaga ggttaagaga 86100 tcaagaccat cctggctaac acggtgaaac cccatctcta ccaaaaatac aaaaaattag 86160 ccaggagtgg tggcgggcgc ctgtagtccc agctactctg gaggctgagg caggagaatg 86220 gcgtgaacct gggaggcgga gcttgcagtg agccgagatc acaccactgc acttcagcct 86280 gggcgacaca gcaagattcc gtctccaaaa aaaaaaaaaa aaacacagct gggcatggtg 86340 gcaggtgcct gtagtcccag ctactggcag gagaattgct tgaacctggg aggtggaagt 86400 tgcagtgagc cgagatcgtg ccactgcact ccggcctggc aacaaagcga gactccgtct 86460 caaacaaaca aacaaaaagt tccatttgct gggtctcaca tgttgcctac aaattcgaga 86520 ttatgctgtt tttcatttta ttttagaaca gtcaccttgt atccaactga tccagcccac 86580 ttttactgcc aaggtgttaa catgcattac atttgctgaa gacagaaaga aaatgaaata 86640 gtcccagccc ctaccctgag gacacaccct cacatcccta ctccttctcc atcagctaaa 86700 ctgtgtgtgt gcagatgtgt gtgtgcctgc tggagtctgg ggtgcaggga ggttggtggt 86760 aacaaaagac catgaggctg agacaatcaa ctagccaggg ttttctgaga agaaagggca 86820 caggcaggga cactgggcaa tacatgcttc tgtctagttc ttttcatctc aagcatggtt 86880 cacgcagtaa aaggtctccc tggactaaat cctgaactaa taaaaagcct ttattttaga 86940 gagagcaggg aagtatgtaa ttgttaaata tcaaggagct aggaaacaca attaaaactt 87000 tgaactggga ggtgaaaagg aggggtaaaa aaacaacaac tttgaactgt aaggtttaaa 87060 aaagttaacc tacctgcata ggattctcct aaattaaaaa taggatctac acaatgctca 87120 gtgttgcccc tgcatctcaa tgaacatacc aacatacctt tgaatacgct ccttaacact 87180 agcacaagtg tgagacttct caccaaaagc tagtatcaag tatgcacacg cgaataagtg 87240 cttactattc catgctatgg ttcacatcta ttcttttaag gcactgagaa tttcaaaaca 87300 cgactctctg taatttgctc tccaaaaact gcttttatta gacactggca ggcctcaaac 87360 tttcatgtct taaagcaaga caaatgctcc tattaaaaag ggactggcag cccaggaatg 87420 ccaaaagctg caagaagtcc aaagcaatct ctcatatcat cacctttata tatacatgca 87480 cgcacataca gttgattaac aggaggcact ccagctttct aaaggaagtt cttttaacta 87540 tatccatact tgctacatac aatgtagcaa gagtaagaga taaagactga aagtatcctc 87600 atgaaagaca ttgtccaaaa aatccaaatt cttttttttt tttttttgag acagtcttgc 87660 tctgtcaccc aggatggagt gcagcaacac aatcaagact cactgcaacc tctgcctcct 87720 gggttcaaat gattctcatg ctcaacctcc tgagtagctg ggattacagg catgtgccac 87780 cacacccagc taatttttgt atttttatta aaatagagac agggttttgc catgttggtc 87840 aggctcaagt gcccggcccc aaaatccaaa ttcttaaaat taccaacctg tacaaagcta 87900 tacctattca tatttgacaa taaaaaacac ctgtgaagac catttgttgt cccactgaaa 87960 actaaggagc atgggctgga tgcttgaggc caggagctca caaccagcct atacaatgta 88020 gaccctttct ctatgtatat gtttaacatg taagaaagaa aagaaagaag gctgtgcact 88080 gtggttcttg cctgtgatcc cagcactttg ggaggttgag gcaggtagat cacttgagcc 88140 cgggagtttg aaatcagcct gggcaacatg gtgaaacccc atctctacaa aaaaatacaa 88200 aatttagcca ggtgtggtag tatacgccta tagtaccagc tactgaggtg gctgaggtag 88260 aaggatcact tgagcccgag aggtcgaggc tgcagtgagc tatgattgtg tcactgcact 88320 caagcctggg taactgagca agaccttgtc tcaaaaacaa aaacaaagta aaaaaaaaaa 88380 aaaaaaaaaa gcaccaaaaa acaaggcaca tggatgaaag gaaatgtgtc atatgctagg 88440 aaagaataga aaatgaccaa ctctagttca aaggaaatat aataatttct attatctacc 88500 tgtttcaaaa agactatagt aaacagctaa gctaatgcgt ttgaaactga aattaagaca 88560 aaaacttgat tgaccatcac gtttaatacc agaatccatt cctagacttg taaaaacaaa 88620 ataaaactcc tgttaacacc ctacttaaaa ccttcaatga gtctggtgcc ggcagcatac 88680 aactccacct gcctccatat ctgcaggctc tcctctgctt attccttggc ctcaccaatc 88740 ctgggactct acagtcatga acactcatta agtttcttga ataatgtggt tttacagctc 88800 tatgcctttg cctcccctcc acccggaatg cccctcaact ccacagctct ctgaaaatgc 88860 ccactcatct ttcaagacca aggtcaaact tcatctcttg gaacagcccc atttccctag 88920 gcaggctgca cattgcaccc cgttgtgtgt ccctttgcca ctcactggga gacaaagttc 88980 atctctctcc tagaatgcaa gctccctaga ataggaaagc catgtctcac ctctcttgtt 89040 accatcttta ctgctttgca cagggtctga cagaaagaag gcaccaaaaa tatttgacta 89100 gaaaataaac tgagaaaaca ctgggatacc atttcacatc catcagatag gcaaaatgtt 89160 agaaagctgg ataaatgatg gtgtggatat gaataaacag gaactctcat atgttgctga 89220 tgggaatgtg agtttggtaa aattactttg aagagtgata tttttcatct ctcgccaagc 89280 tgaaaatgag cactgtcaaa gcagcaattc tgcttcaggt tacatacatt agactattat 89340 ttgtcaaata ttgtcctgat cagcttattt ttaaatgaag ggatatttat tcatatctca 89400 agtatgcatc tctcacattg tatgcgtaaa tattttttca gggtaaatat tttataaaac 89460 tataatttct attacatgta aatatttatg catatatata tgaacattat gcaaataaac 89520 acacacatat tttgggtatc aatgtaaaat acatttctta ctgtgtctag tgaacaaaaa 89580 aggcttgaaa aacactatcc cagaaaaaca catatgtgct caaaaagaca ctcataaatg 89640 ttaattatga cactgtatat aacggtgaaa aactggaaat aacctaaatg tgcattaaca 89700 aaatggaaaa aatatggtac acatataact caatataaat gaactggaaa caaatgaagt 89760 aaagctacta gaatacttct aataatatca ataaatctta aaagtaatat tgaatcaaaa 89820 tgtatattta tataaacata caaaatacta catacataca tatatgagaa aataaacatg 89880 aatggtatga tgacaattca agaagacagg gagggaagcg gaatcaggaa agacatcaca 89940 ggaggcttta gtgtaacttc aggtgttatt acctcaaaaa aaagttctga agacaatgtt 90000 aaaatctgac aactgggaaa tggatgctgt tcattatttt attccacata tttgttgtgg 90060 tgcttaaaat attttgtcat tgaaaacaat gtaataaaca aatgactaga aaaagtcaaa 90120 aaaaaaaaaa aaaaaaaaag caatctttaa aatgtcctgg tgttggccgg gcacagtggc 90180 tcactgttta ggtggtcaaa gtgggaggat cacttgaggc caggagtttg agaacaacct 90240 ggacaaccta tcaagactct ctgcctctaa aaaaaaaaag tcctggtgtt tatagttcca 90300 aatcaatata tattacacgt gatttttttt tttaaagcta acattggtgt gcttatgtgt 90360 tagatactgt gctaaccact actacacaat ttcacttact tggtaacaat gaccctttgc 90420 agcaggtacc attattttct gctagactgt gtcactgtct ctgatcttta ctcttgaggg 90480 tccaattgta ctcatcattc tatattttct aagggcagaa aaatggactc atctatttag 90540 agacagggtc tcactctgtc acctaggctg gagtgcattg gtgcaatcat agctcactgc 90600 aggatcaacc tgctgggctc aagcaaactt tttaaaatat gcagctacaa aagcaaattt 90660 aaaccctaat ttaaaagctg attttgccgg gcatggtggc tcacgcctgt aatcccagca 90720 ctttgggagg ccgaggcggg cggatgactt gaggtcaggc gttcaagacc aggctggcca 90780 acacagtgaa accctgtctc tactaaaaat acaaaaaatt agccaggcat ggtggcacac 90840 gtctgtggtc ccagctactt gggaggctga ggcaggagaa tcacttgaac ctgggaggca 90900 gaggttgtag tgagctgaga tcacgccact gcatctagcc tgggcaacaa gagactctgt 90960 cacaaaaaaa aaaaaaaaaa aaaagctgac ttcataaatt attagaatga atgagaacat 91020 ttttcccact aacattgcat gggtttcaaa ccaatctttt tggcgctaac tttgtctaat 91080 tactgttgtt taaaatgtaa aaatacaggc tttctttctt tgaaagtggc tagacaaaac 91140 atctcaccat ttcaatattt cctctatgga tattacatga tataattgaa gttactatta 91200 atatcctctg gtgtgataat ggtactgtgt ttatgtaaga aaagtcctta ttctttttta 91260 attttttttt tttagacagt ctcactttgt cacccaggct ggagtgcagt ggcacgatct 91320 cggctcactg caacctctgc ctcctgggtt ggagcaattc tcctgcctca gcctcctgag 91380 tagctgagac tacaggtgtg caccagccac cacgcctggc taatttttgt atttttagta 91440 gagatgggtt tctgccatgt tggccaggct ggtcttgaac tcctgacctc aggtgatcca 91500 cccacctcag cctcccagag tgctaggatt acaggcatga gccaccgtgc ctggcctttt 91560 aatttttatt ttgagatgga gtcttgctct ggcacccagg ctggaatgca atggcatgat 91620 ctcggctcac tgtaacctct gcctcttggg ctcaagtgat tctcctgcct caaccttctg 91680 agtagctggg attacaggca gacgccatca cgcctggcta atttttgtag agatgggatt 91740 tcaacatttt ggccatgctg gtctcgaact cctgacctca agtgatccac ccgcctcggc 91800 ttctcaaaat cctgaggtta caggcatgag ccactgtgcc cagaaaaaca gtccttattc 91860 tttgaagatg catgttaaag tatttacact gaagtctcac agtatttgca aattataaat 91920 ggctcagcca aaaatatgag atagcaaata tagcaaaata ttgagtctac atagtagggt 91980 ggtatacaga tatttattta tactattcta attatatgta tctgagttat tttgttttag 92040 agatggggat cttgctatat tgcccagact gacttgaact cctgggctta aacgatcctc 92100 cagcctcagc ctcccaagta gctgggacta caagtgcaca cacagtgcct ggcttgtatc 92160 tgagattttt cttttttttc ttttttttga gaaggagtct cgctctgtcg cccaggttgg 92220 agtgcagtgg catgatctcg gctcactgca agctccgcct cccaggttca tgctattctc 92280 ctgcctcagc ctcagagtag ctgggattac aggcacccgc caccaagccc agctaatttt 92340 ttgtattttt agtagagaca gggttccacc gtgttagcca ggatgttctc aatctcctga 92400 cctcgtgatc cacccgcctc ggcctcccaa gtgctgaaag aaaaatttcc agtccataac 92460 tgttaaacaa gaaacttaat attgccatta ttatgcaatt caatctgaat tacccttatc 92520 aactaacttc caaaataaaa taaagtttta cctgcttttc gtaagtttgg ttttattcac 92580 aactatgtgg cagctaaaat aaagatctac agtcatatcc atgttaaagg cctactacta 92640 tattttaacc aataaatatt actaccaacc cagagtttgt tctgcaatat cattaatcat 92700 aatttgaagc agccctctct tgctatggac aagcttagac actttttatg tgactagaag 92760 ttatatagta atttagaaaa tcataaaact gataaccaat ttcctcaata acatttccaa 92820 gtaataagcc aaatttaggt taaagaatct ataacacctt ggccagatgt ggtggctcac 92880 acctgtaatc tcaggtagga gaggttctaa aacatggaag ctttctgaaa cctattgttc 92940 ataatgccag ggatcaggaa cagtgatgga gaaatttact gggttgaaat tacaaaatta 93000 tttgaaataa ttctcacaag ggcctgtccc atccactaag ccatactgtc tctctagatg 93060 tattccacat gaaaaacaaa actgaaacaa gacacgaggg aactgtaagt ttccatcaag 93120 tgaacaaata gatactctca ctccacagga tagaatcaga agacattctt aactagctcc 93180 ccatattgga caagggccat taacatcttg actcaactct accatccgta acaacagcaa 93240 aaactgattc attcacagag taggccaaag tctgacctca gcagggcaaa caaagcattt 93300 gaattattag ataagcagat tatgaacact ggatagcatt ttaataatta taccttcagg 93360 atgggcatgg tggttcacac ttgcaatcct agcacttcag gaggccaaag taataggatc 93420 acttgagcct gggagttaga gatcagcctg ggcaatatag tgagaccctg tctctacaaa 93480 aacatttgtt taaaattata ctttcacaat actccatcta attccaggga tccatttcta 93540 gaaatgaaag gataacaaca catcattact aatggcgtaa gactgagact tttcctagtt 93600 aacattaaca caggtttctg aatgtgaaat atttcactgc cacattttaa aattccaaat 93660 gaaggtgtta aaaggttttc tactttgaac ttctaaaaaa gccctagtaa aaattcatac 93720 caagaaggta ataaattgca gaatttatct agttttactg tgcatatttc tctgcaaaga 93780 gaataagatt caaaatgaga ttttatgtca taactctatc ttcaattctg tattccctag 93840 aaggcaatac caggtataca tatggttgtg aaggcctttt acattcacac acacacacac 93900 acacacacac acacacagaa aataagagtt gcatgtataa tgtctacata taaaatcaga 93960 atattcaagt tggagagact taaaatcatc taaaccaact ccttatttga tagataagga 94020 cacagataac ccaagaagga agtgaaagcc ccaaggtctc tgagccgcac agagccaagg 94080 acgaaagccc tggacggtcc tccaggcagt ctcctttcct cccaacactc tgcctctcct 94140 ctaccaacct tcaaccaccg ctgaactccc aaatcaggtc ctctgagtta aaggttgagg 94200 gtacaagcta aactatgaat aaaaaaaaaa aagtttaact ttttgttttc ctttaatgct 94260 caaggtaagt aattttatca cataagccca gtcccccagc aaagcagaac ccgaaagaca 94320 taagatattc acaaatggcc aggcacggtg gttcacgcct ataatcccag cactttggga 94380 ggccaaggtg ggtggatcac gaggtcagga gttcaagacc agcctggcca agatggagaa 94440 accccgtctc tactaaaaat acaaaaatta gctgggcgta gtggcgagct cctgtaatcc 94500 cagctactcg ggaggctgac gaagagaatt gcttgaatcc aggaggcaga ggttgcagtg 94560 agccaagatt acgccactgc actccagact gggcaacaga gcaagactca gtctcgaaaa 94620 aaaaaagata ttcataaaca aaaattcacg gtgttctcca ggtggaaaaa aaacaagaaa 94680 aaaataaaat ccacaatgtg ggacagttca tgggagctag gcctatacaa taatgctccc 94740 aaatatgtaa atgaaagaaa aaagcgaaac aacattcact gtgaaagaca ctgtacgtga 94800 tccaacccag tatccattct ctccttctta ctatcaaaac cccgattgta ttcagggcag 94860 tcaaagagcc ttgtttccca gcctttcttg caacgagaca cttctagctc aggatgatca 94920 gggcaatgtg tagggaggga cactcagaaa agttcctttg gtcattggag gaggggaata 94980 gtctcagcta gctcttagcc ttctgcctat tcaccccttt cttcctccca ctgcatgaaa 95040 cagtgacgtg atggcagaag cgatgccttt aagattaagt aatgcactga agagggctgg 95100 gaatacacac tgcggcaatc tggattccct gatgacatga agcccgccct tatctgcctc 95160 cctaacttac catcacaact acattattcc agaactgtta ctaccagcca actacaattc 95220 ctaactgatc tgtccagtaa gcaattacat gctaaataca ttcacataca tttcatataa 95280 aataacctca aaacaaatta taagtatttc cttccttttt cggttgagga aaccaaggca 95340 aagagataac aaatccaatc tgtgactgaa gcctatagtt attccactgt attttacttc 95400 ttcaaatgtc acacatctga aaaagtctat gattttttct tttcaagata aagggtcttg 95460 ctctgttgcc caggctggtc tgaaactcct ggcctcggcc cggcacagtg gctcatgcct 95520 gtaatcccag cactttggga ggctgaggtg ggtggatcac ctgaggtcag gagttcgaga 95580 ccagcctgac caacatggag aaaccccttc tctactaaaa atacaaaatt agcccagtgt 95640 ggtggcacat gcctgtaatc ccagctactc aggaggctga ggcaggagaa tcgcttgaac 95700 ccaggaggca gaggctgcag tgagctgaga tcacaccatt gcactccgcc tgggcaacaa 95760 gagctaaact ccgtctcaaa aaaaaaaaaa gaaaaaagaa actcctggcc tcgagtgatt 95820 ctcccacctc agcctcctga gtcgctgaaa ttacagtcat gagccacctg aaaaagcaga 95880 ggcatttcaa aaaattatct caatcattct catataatgt gccacaaatc cattcactgt 95940 cttctaattc attaaaaccc tgccaaccat gattggattt caacctgtga gtaaattctt 96000 taccaagagt cctcctctgg ctgactgata agtgatcaca cctccagaaa agtatcaggt 96060 atggccctac tggttgcaga gtgtcagatc ataaaaagct cagccccttc tccatacagc 96120 agcccacata atcttggtca caaacgccac gctctagtac atactagtac atatgtactt 96180 aacagtaact tatttacaac ctgattcttt aatcaagata acctaccaac cgcctcatac 96240 ctcatgagtg ccctcttgct catctatctc ctgtctctat gacattctgc ttccaccagg 96300 aagccttctc tgatagactc aactctgtgc ttttccaagg ccctattctc ctttttaaaa 96360 cgtacttcta aggatgccta ggctttttat tcatacacta tcttcataac tccatgtaat 96420 ggtcctatta tttttataca gaataaaaca gagacactaa aatgttaata atagaattca 96480 gtaacttttt taagaaacct attagaaatt taaaaatgtg ggcaacttcg ccaggtgcgg 96540 tggctcatgc ctgtaatccc agcactttga gaggcagagg ggggtggatc acaaggtcag 96600 gaattcaaga ccagcctggc caagatcgtg aaaccccgtc tctactaaaa atacaaaaat 96660 tagccgggcg tggtggtgga ctcctgtaat cccagctact tggggaggct gaggcagaga 96720 attgcttgaa ccctggaggc agaggttgca gtgagccgag attgcgccac tgcactccag 96780 cctggctgac agagcgagac tccgtctcaa aaataaaaac acaacaaaaa aatgtgggca 96840 acaaataaat ggataaaatg tggtatgtaa tacactatat atgaatacta ttcagccata 96900 aaaaaattaa aaccacatct tataattccc agcatcatgg atgagtttag gggacattac 96960 gttaagtaaa ataaagcagg cacgcaaaga catgtatcgc atattctcac tcatacgtgg 97020 gagctaaaaa agttaatttc atagaaatgg agcagaatag tggttactag agtctggtgg 97080 ggaggtagcc agagatcggt taacaaatac caaattacag atagataaga gaaataagtc 97140 ttagtgtgca ttcgaaggtg accataatta acaatttatt gtagctgagc gcagtggctc 97200 acacctgtaa ttccagcact ttgggaggcg ggtcagttga gcccaggagt ttaaaaccaa 97260 cctgggcaac atggcgaaat accatctcaa aattaaaaaa aaaaaaaaaa aaaaaatttg 97320 gctgggctca gtggctcacg cctgtaatcc caatactttg ggaggctgag gcaggcggat 97380 catgaggtct ggggttcaag accatcctgg ccaacacggt gaaaccctgt gcctactaaa 97440 aatacaaaaa agagccaggc atggtgacac gtgcctgtag tccacttggg aggctgaggc 97500 aggagaagtg cttcaactcc agcctggcga cagagcaagt ctctgtctca aaaaaacaaa 97560 aataaaaaca aaaaacaaac acaacttatg gccaggcacg gtggctcatg cctgtaatcc 97620 cagcactttg ggaggccaag gcaggtggat catttgaggt caggagttca agaccagcct 97680 cgccaacatg gtgaaacctc gtctctacta aaaatacaaa aattagccgg gtgtggtggc 97740 acacacctgt aatcccagct actcagaagc ctgaggcaga agaattgctt gaactcggga 97800 ggtggaggtt gcagtgagcc gagattgcac caatgcactc cagcctgcgc gacaaagcga 97860 gactccgtct caaaaataaa taaataaata aaaacaaata ttttgtcttt tcaaataact 97920 agaagagtgg attttggatg ttcccaacac aaagaagtga taaataaggt gacagatatg 97980 cccaatttga tcattacaca ttgaatacat ctatagaagt atcactgtat gccataaata 98040 tgtcaattaa aactaaatat atatatacat atataaagag gagaaaatca acaatatggt 98100 taaacagaaa aaaggctctg catattaaaa aagatacaca aatatgagtt ttacactttg 98160 ttttaaaaga cttgaattct agcattgaaa tctagttttc ttgcttgaaa taaagataac 98220 tgctttatga atagaatatt ccaacaatga gtgcactgtc aattgcccag agtcaattaa 98280 gtgcctgata agagtaacat ttaggggcca ggcacggtgg ctcacgcctg taatcccagc 98340 actttgggag gccgaggcag gcggatcacc tgaggtcggg agtttgagac cagcctgaac 98400 aacatggaga aaccccgtct ctactaaaaa tacaaaatta gctggcgtgg tggcacatgc 98460 cggtaatccc agctacttgg ggggccgagg caggagaatc acttgaatcc aggaggcaga 98520 ggttgcggtg agccaagatc gtgccattgc actccagcct gggcaacaag agtgaaactc 98580 catctcaaaa aaaaaaaaaa aaagaagagt aacatttaat gcaccatatc ccgtagctca 98640 agaactgaac tgctatccag tatgtttcct tctcctctcc acacaaaaag agacactagc 98700 acatttcatt acatctatga cacaccatta ttttatgaca caccaagaaa gaaaaaagct 98760 gcccattaga ctatgactta tcaccatttt aagacatctc aatttcaaag atgttaagat 98820 gtgggaaaaa aaggtctcag aatctataaa atacaagata aaccagacac tgtttactga 98880 cataaaaaca cttaccatct tcacacgcca ccaatattcc ttcttagcta aatgtgtatt 98940 tacatggttt actgaataat tctatccagt ctggttcaaa tattatatta acacattgcc 99000 aggcacagtg gctgatgcct gtaatcccag cactttggga ggccaaggcg ggctgatcac 99060 ttgaggtcag gcgttcgaga ccagcctggc caacatggtg aaactctgtc tctactaaaa 99120 caacaaaatt agccaggtgt ggtggcaggc cccttgtaat cccagctact tgagaggctg 99180 aggcagaaga gtcacttgaa cccaggaggt ggaggttaca gcgagccaag atcgcactgc 99240 tgcactccag cctgggcgac aaagactcca tctcaaaaaa caaaacaaaa caaaaaaaac 99300 ggatatacaa gaaactgtgc taggttacaa ttaaagcaca tcctagactt tatcataata 99360 tgacttctct tccaatatac atttgttagg agtagtagct ctcaaacact ctggtctcag 99420 cacgctttac actctgtatt tttttttgcg atggggtttc gctcttgttg cccacgctgc 99480 agtgtaatgg cacgatctcg gctcactgca acctctgcct cctgggttca agtaattctc 99540 ctgcctcagc ctccggagta gctgggatta caggcatgcg ccaccatgac cagctaattt 99600 tgtattttta gtagagacga ggtttctcca tgttgctcaa gctggtctca aactcccgac 99660 gacctcaggt gacctgccca ccttggcctc ccaaagtgtt gggattacag gcgtgagcca 99720 cctcatgcgg tctacattct taaaaattaa agacctcggc tgggcatggt gacttacgcc 99780 tgtaatccca gtactttggg aggccaaggc gggtggatca cgaggtcagg tgttcaagac 99840 cagcctggcc aacatggtga aaacccatct ctactaaaaa taaaaaaaaa ttaacagctg 99900 ggcacagtgg ctcacacctg taatcccagc actttgggag gccgaggcgg gtggatcacg 99960 aggttaggaa atcgagacca tcctggctaa cacggtgaaa ccccatctct actaaaaata 100020 caaaaaatta gccgggcatg gtggtacgcg cctgtagtcc cagctactcc ggaggctgag 100080 gcaggaaaat tgcttaaagc caggaggcag gggttgcagt gagccgagat cgccccactg 100140 cactccagcc tgggtgagag agcgagaccc cgtctcacaa aaaaaaaaaa aaaaaaaaaa 100200 aacaaggccg ggcacagtgg ctcacacctg caatcccagc actttgggag gctgaggcag 100260 gtggatcacc tgaggtcagg agttcaagac cagcctgacc aacatggtga aacccaatct 100320 ctattaaata caaaaaatta gctgggcgtg gtggtgcatg cctgtagtcc cagctacttg 100380 ggaggctgag gcaggagaat cgcttgaacc caggaggcac aggttgcagc agtgagctga 100440 gattgtgcca ctgcactcca gcctgggcaa caagagcaaa accctgtctc aaaaagaaaa 100500 aaaaaaaatt gccacgcgtg gtggtatgcg cctgtaatcc cagctactgg agaggctgag 100560 gcaggagaat tgcctgaacc caggaggcgg aggttgcagt gagctgagat cacgccatgg 100620 cactccagcc tgggcaacag agtaagactc tgtcttgggg aaagaaaaaa aaaacctgaa 100680 gacctcaaag agcttttcta tgtgtgttat ttaccatttt agaaacacaa aatattaatt 100740 catttaaaag taaatcttat gcatataaat ataaatcatc tttaagaaaa aaaaaactaa 100800 tttccaaaac aaagaataac atagtaagaa cagtttttaa tcattttgca actctcttta 100860 atatccagct taagaaaaga aagctggatt ttcatatgtg cttctgtatt gaatctggta 100920 tgttttgaat gtaattggaa aagagtactt taacagactt ttcagataat tctggacatt 100980 ttttgttgat ataatgccaa aattgacaag cagttgtctc gtaaaggcta actgcaatgt 101040 ggaatcttaa attgtaccaa cgaacttttc atattcttat attaaaatcc actgttctac 101100 tttgcttttt tttttttttt ttgagacgga gtccagctct gtcacccagg ctggagtgca 101160 gtggcacaat ctcagctccg cctcccaggt ttaagcgatt ctactcctca gcctccccag 101220 taacagggat tacaagcgcc cgccaccaca cccagctaat ttttgtactt ttagtagaga 101280 tggggtttca ctgtgttggc caagctagtc tcaaactcct gaccacgtga tccgcctgcc 101340 tcggcctccc aaagtgctgg gattacaagt gtgagccact gcgcccagcc cactttgctt 101400 ttttttttgg agatggagtc tcgctcttgt tgcccaggct ggagtgcagt ggcgcaatct 101460 cggctcactg caagctccac ctcccgggtt cacaccattc tcctgcctca gccccctgag 101520 tagctgggac tacaggcgcc cgccaccacg cccggctaat tttttgtatt tttagtagag 101580 atggggtttc actgtgttag ccaggatggt ctcaatctcc tgacctcatg atccacccac 101640 ctcggcctcc caaagtgctg ggattatagg cgtgaggcac cacgcccagc ctactttgca 101700 tttttaatgg atcttttaac caggcataat ttttctgtca tgcactggcc atttggaaaa 101760 cagttttcac tgacttacac agatcttcca aatgttgaca ccatttcatc atacatcaaa 101820 aatcctgtca gaggagatcg agaccacgct ggctaacaca gtgaaacccc gtctctacta 101880 aaaatacaaa aaattagccg ggcgtggtgg tgggcacctg tagtcccagc tactcgggag 101940 gctgaggcag aagaattgcc tgaacccgga aggcggaggt tgcagtgagc taagatcacg 102000 ccattgcact ccagcctggg cgacagagcg agactccgtc tcaaaaaaaa aaaaaaaaaa 102060 aaaaaagtcc tgtcagaact gtctatctac atcagaaaac tgttggctgg gcaaaaaggg 102120 cacataatga atcaatatta ctatgaaaag ttctgacctc acattcccct tgaaagtatc 102180 ttggggatcc ctagggggct ccagacatca cctgtgccag aacctctgtt acttaccaaa 102240 aacctaaaga gtaaaattct gttcctcttt caccaagcac atgtccacaa acaaagaaaa 102300 acaaaagcta tacttatgtg tatatacatt taaatataac actaaacttc aggttttgca 102360 tctgtaaaat gagattttaa atatctggtt taagtatctt tcctattatt ctgaataact 102420 aagaaaaggc cacatacttt tatggaaggt gtgagctgct gaagtagttc ttaagtcctc 102480 ttttgtcaca gaatacaggt gaaaggtaaa aataaacaca acataaaggt ccttaatgaa 102540 gtcctgagca aactaagaag ttgacagtat caaatattaa ggaaaacccc ttttagaact 102600 tctaaatttg taaggaggaa ctggaaacac tttgcaactt ataaaacagg gtactaaaaa 102660 gctccataat ttggatgagt ttaaggtatt ctattttaca aatgaagtaa agcaagtttc 102720 agctgtttct ttccccaatg cacaacctta atttcctttt atcttaaaca ccaggaatca 102780 aacaatctca accatctgaa aacggcattg aataacctat aaggtattag catttaggac 102840 catttaagaa aacaaacaca cgttacatgt gggaaaatga acactacata aaaaggcaaa 102900 tgacatccac acagaaaaga attgaattcc ccatcattgg aggaagattc aacactttcc 102960 tgcaagattt ccatatcgtt tcaattgcag gtgccaaagt ttagtctaaa aatgacctaa 103020 ggacttggtg aaaacccagt agtatataat ttattctaat ccgtttaaca ggtgtttgct 103080 gagcatctac tacacaggca aagctataag ggacaaaagc ttaggaaacc atagttagcc 103140 ccagatccac tgtgataagg acttactctg atctcagcac ctttaactga cctgtgtggt 103200 ccagattttt aacccacaaa aagtgggcca taacatctca aagcaaaaat gctgcaagga 103260 taaacgtgaa atgtattaga atgaaaagta cattatagag caatgacaag ccaggcacag 103320 tcactcatgc ctgtaatccc agcactttgc gaggccaagg tgggcagatc acttgagctc 103380 aggagtttga gaccaccctg ggcaacatgg tgaaacccta tctctactaa aattacaaaa 103440 attatccggg cattatagca cacgactgta ctcctagcta ctcaggaggc tgaggcagga 103500 ggaccgcttg agcctgggag gtggaggttg cagtgagccg agaaagcacc actgcactcc 103560 agcctaggca acacagaccg accttgcttt aaaaacaaaa aagaacaaca aaaacatgag 103620 ctgaggccag gagtggtggc tcacacctat aatctcagca ctttgggagg ccaaggcggg 103680 tggatcacct gaggtcagga gttcaagacc agcctggcca atatggtgaa accctgtctc 103740 tactaaaact acaaaaatta gtcgggcatg gtcgtgggca cctgtaatcc cagctactca 103800 ggagactgag gcaggagaat cgcttgaacc tgggaggtag aggttgcaat gagccaagat 103860 catgccactg cactccagcc tgggcgacag agcaagactc cgtctttaaa aaaaaaaaaa 103920 aaaaaaaaaa agctgaaata aaaacacata caccaaaaat catcaaggtt ttctcattta 103980 aaggagtaat ttcaactgct tagaaaattc tgaagtggaa aatatatata aaaaaataaa 104040 ataaaaattt taaaaaacag tcagggtggc tcaccctgta atcccagcac tttgggaggc 104100 caaggtagcc agatcacttg aggtcaggag ttcaaaaaca gacaggacaa gaccccattt 104160 ctacaaaaag tatatatatg tgtgtgtgta tatatatgtg tatatatata tatatgtgtg 104220 tgtgtgtata tatatgtgta tatatgtgtg tgtatatata tgtgtgtgta tatgtgtgtg 104280 tgtgtgtgta tatatatata tgcaccacaa aatagaggtg aaaggtaaaa ataaacatat 104340 gtatatatag aggtatacat agaagcagaa atatatatag ataaatatat aacttttaaa 104400 aataaattta aggctgggca tggtggctca catctgtaat cccaccatta tgggaggctg 104460 aggtgggcag atcacgaggt caggagttca agaccaacat ggtgaaaccc tgtatctact 104520 aaaaatacaa aaatttgctg ggcgtggtag tgcatgcctg aatcccagct actcaggagg 104580 ctgaggcagg agaatcgctt gaacccgaga ggcgagggtc atagtgagct gacatcacac 104640 cactgcactc cagcctgggc gacagagcga gactgtctca aagaaaaaaa aaaaaaaaac 104700 agaaaagaaa atataactca ggtaattaaa tacataaaac tttgaaatga aaacagcatg 104760 ctgccattct atcctgacaa aagcttccat aaatcaggca cttttacagc acttattcta 104820 ttctttaaat taacagggta aatacaattc tgacacctta agaaaagatg caatgccatc 104880 taatctattg ttgtagagag gtaccagaac actgatatta aaatctacta agtcattttt 104940 atttttcttt acgaatctta tattgataag caggattaac agacattact aggctgttgt 105000 tttaattcta tttttcacac aacaaacatg actactagta aaactgatgt taatcacagt 105060 tgaaaagtag tatcctctca actttcatct gtttttttct atcaataata acaaagttac 105120 cagagtttac tctcctaatc tgaagcggta cagtcaagca ttaatgaagt gtacagtcaa 105180 gcattattac ttcttaagct actatttaag gcaacaaatg ctattattgc ctagagagaa 105240 tatgattatt aatttccaca ctaagagccc ttatattcgg aaagccacca ttgctttgta 105300 atactagtat ttgcagtcca ggttttctcg aagtataaaa acatgctaaa atctatgact 105360 ctaataccta ttaaaattta actttaaata ataagatgcc atcagaactt catcagaact 105420 gacaaaacac tttaagaatg acatttaaga aataaaactg ccagaactgg cagactaaaa 105480 ccatcatgtt ttatccaatt cattcaagtg agtaatatgc ccaatttaaa agcacacaag 105540 tcacaaactg atttctgatt ctacaaaaaa tagaatttct aagccgggca cggtggctca 105600 cgcctgtaat cccagtactt tgggaggccg aggcgggcag atcacgaggt caggagatcg 105660 agaccatcct ggctaacatg gtgaaactcc gtctctacta aaaatacaaa aaattagccg 105720 ggcgtagtgg cgggcgcctg tagtcccagc tactcgggag gctgaggcag gagaatggca 105780 tgaacccagg aggcggagct tgcagtgagc tgagattgcg ccactgcact ccagcctggg 105840 tgacacagcc agactccatc tcaaaaaaaa aaaaaaaata gaatttctaa ttctcattaa 105900 gcaaataaaa agatacatat gtccattaag ataatccagt tcaggccacg tgcagtggct 105960 tgtgcctgta atcctagcac tttgggaggc caaggcaggt ggatcacctg aggtcaggag 106020 ttcgagacca gcctagagcc tggccaacat ggtgaaaccc cgtctctact aggaaaaaaa 106080 aaaaaaaaaa aaaaaagtta gccaggtgtg gtggcaggcg cctgtaatcc cagctaccca 106140 ggaggctgag gcaggaaaat cgcttgaact ggggagacag aggttgcagt gagccgagat 106200 cacgccacta tactccagcc tgggcaacaa gtgtgaggct ccatatcaaa ataacaaaca 106260 aacaaacaac aacaacaaaa aaaacacaca gacttgaaaa catacaattt atgggccagg 106320 tgtggtggtg gctcgcgcct gtagtcccag cactctggga ggctgaggcg gatggatcac 106380 gaggtcagga gatcgagacc atcctggcca acacagtgaa accccgtctc tacaaaaata 106440 caaaaaaatt agccgggcat ggtggcaggc acctgtagcc ccagctactc ggaaggctga 106500 ggcaggagaa tggcgtgaac ccaggaggca gagcttgcag tgagccgaga tcacacaact 106560 gcacttcggc ctgggcaaca gagtgagact ccatctcaaa acaaaaaaaa gaaaaaagaa 106620 aaaacataca atttatgaaa atgaaatgaa attacagtct ttatgaacca caaatacagt 106680 ttttcagata tatcatggtt tatatgttat atataaaact cttaactaaa tctcaaacaa 106740 gggaaaagtc acattaatta ctccaagaga aagaactggt tactaactac tttaatgcag 106800 gagctcgtgg ataaaaaaga tgagtggata aaaaagcaag tgagtattca caacagcatg 106860 acaaacaaca caggtatact cacatatatg gcatttgata atcagagaca gcactttagc 106920 tgcctttctt cactgcctag agaaatgggc agcaatcaag gcattcaaag gtctacctcc 106980 tttccttctt ccaaccataa aaccaaccta actcaaaaga aaggtatttt aaatctttat 107040 agataaaaat gaatagagtg acaaaataca tcatttgttt tttctttatt cattatcaag 107100 atggtggcta tgaagaacta aatgaatcag gtttgtaaag ttaacagatg ctaataatgt 107160 catattgtga tgcaaagatg agtgctttta tcctcagttc ccttgataat tgtgttatca 107220 aacacatatt gtgttcaatg ttttagtgtg cttaagtaca cttaagagca acgttaatat 107280 ctaatatcag ccaccaagat aaaaggctaa aactcctgtc aaaactacta cacatactga 107340 aaattctttt ccctcctgtt ttcatctatt tgaatataat ttgtaataaa aatccatggc 107400 caggcacaat ggttcacaac tgtaatccca gcactttgga aggccaaggc aagaggattg 107460 cttgaactca ggagttcaag aacagcctgg gcaacatggc aaaaccctgt ctctacaaaa 107520 atatacaaaa attagctggg catggtggcg tgtgactgta gttccagcta ctcaggggga 107580 tgaggcggga ttgctttgca cccaggaggt caaggcttca gtgagccatg atggcaccac 107640 tgcactccag cgtgggcaac agagagagag actgcctcat tcaaaaaaaa aaaaaaaaaa 107700 aaaaaaaaaa ggctggctca tgcttgcaat cccagcactt tgaaaggccg aggcgggtgg 107760 atcacctgag gtcaggagtt caaaaccacc ctgaccaata tggagaaacc cgtctctact 107820 aaaaatacaa aattagctgg gcatggtggc acatgcctgt aatcccagct actcgatagg 107880 ctgagaattg tttgaacccg ggaggcggag gttgtggtga gtcgagatta cgccattgca 107940 ctccagcctg ggcgccaaga gcaaaacttc gtctcaaaaa aaaaaaaaca aagccgaccc 108000 aaactgtcca agattcccct cacaagatta tgtacttgta ggcttagttt gatgtttttg 108060 tttttttgtt ttttttgttt ttttttgaga cagagtctca gtctgtcacc aggctggagt 108120 gcagtgatgc gatctcggct ccctgcaacc tccacctcct aggttcaagc aattctcctg 108180 cctcagcctc ccgagcagct ttgattacag gcgcctgcca ccacacccaa ctaacttttg 108240 tatttttagt agagatgggg cttcaccatg ttggccaggc tggtctcgaa ctcctgacct 108300 caggtgatct atccgccttg gcgtcccaaa gtgctacgat tacaggcatg agccaccacg 108360 cccggcctct agtttgaatt aatgatctga tcaagtacaa ttcacagctg tgagaaccaa 108420 atgccatata aaagtgactg tttttttaat ttttagagac agggtctcac tatagtgctc 108480 aggtgggaga atgcagtgac tattcacagg cacagtcatt gtacactaca gccttggact 108540 caagcaatcc tcctgcttca gccttcccag tagctgggac tgaaggaatg agccactgca 108600 accagcgaaa gtgagcattt gttacccagt ttccttcttt cggaatacaa ttaaaagagt 108660 tatatagttc caagctttgc tgccaaggag aatcactaat ttatttacag gtttagattc 108720 aagaatagca aaagggtagt aaacatccag cagtaagacc atgaaaacat tatatccatc 108780 tatatattac tcttggtgat ctcttactga tatgacttta accaatcaac cttctacata 108840 caaatgctac aatggaaatg tccaaccaaa ttctgaattt ttaaattaat caacttatca 108900 gcaactgtct atgcaacata gtcatcaaat tgaaaagcaa aatccaggct gggcacggtg 108960 gctcatgcct gtaatcccag cactttggga ggccaaagca ggtggatcac gaggtcagga 109020 gtttgagacc agcctggcca acatggtgaa accccatctc tactaaagat acaaaaaatt 109080 agccgggcat ggtggcgcgt gcctgtaatc ccagctactc gggagcctga ggcaggagaa 109140 tcgcttgaac ctgagaggcg gagattgcag tgagccgaga tggagccact gcactccaga 109200 ctgggcgaca acatgagact ccatctcaaa aaaaaaaaga aagaaagaaa gaaagaaaag 109260 caaaatccag attaccaaag ttatactggc accctttgga caaaacaact aaatttactt 109320 tttgctaggc taagtgacag cccaattgct tctgaggtaa cacaaaccag acacgcactc 109380 tgtatctagt tttctattta tattacctca actaagattt tataatccaa aaaaccttga 109440 aaagtgtaca tgataacttg atatatgaaa aaaagttgcc taatactaaa aaggaaatgc 109500 ataattcaca acattaataa catgattttg tatgtaggga gtatctccta ccttcacata 109560 taatgcttcc ctaaaaatgg tttaaaagtt agaaaccagg agattgaacc aaagacaaag 109620 attacattct caattaattg atatcctaaa tatggatcct ccaagtgcta cagaacaggt 109680 gccttttttg agtccactga cagacccgcc aaccatgcct atcttctaga gaatggcaaa 109740 gtcttccaga gaatggcaaa gtccagccaa gcctctccct tcacaagggc tacctactcc 109800 tctctctgac ttctctgcag ggacaggtca gaagatcagc agcaactatt cacactgcct 109860 acataacgtc ctagatacct acaaagcagg gagaggcaaa aaggatcctc cttccctctt 109920 aagcatatgg ctgccatgta gggcttcccc aggctcttga ggatttgggt tctactggtc 109980 atgggcagat acccccttga gcaccagcct ataaacaacc agacaccttc cccaagcatc 110040 tggtgaggta cagagaagaa attacaataa ccatagtacc tgggccccca aaagcttaat 110100 tcttctccaa tgtgataccc aattgagaat cactaatgca acaacagcct ctcaacagac 110160 tactgtgttt tcaaaagttt ctacaatgca ctcgaattac acttcagcat agaaaataac 110220 aaactggaat cttttttttt ggagacggag tcacagtctg ttgcccaggc tgtagtacaa 110280 tggcaccatc tcagctcact gcaacctcca cctcccgggt tcaagcaatt ctcctgcctc 110340 agcctcccaa gtagccggga ctacaggcgc aagccaccac gcccggctaa ttttttgtat 110400 tttagtagag acagggtttc accatgttgc ccaggctggt tggtctcgaa ctcctgagtt 110460 caagcaacgc ccggctaatt ttttgtattt tagtagagac agggtttcac catgttgccc 110520 aggctggttg gtctcgaact cctgagttca agcaatgccc ggctaatttt ttgtatttta 110580 gtagagacag ggtttcacta tgttgcccag gctggttggt ctcgaactcc cgagttcaag 110640 caatctgccc acctcagcct cccaaagtgc taggattaca ggcatgagcc actgcgtctg 110700 gccaagacac tggaatttat atgctcaggg caccattcct gtgtctgaat accaaaacag 110760 tctactcacc aaacatacta tcattgctcc aaactaaaac aggtacaagc caggtcacct 110820 ttttgttagc caaactaaaa gttccagctg tcagtaatat taattttttt tgagacaggg 110880 tctcactctg ttgtccaggc tggagtgcag tggcataatg atggcttgct gcaccctcaa 110940 tctcctgagc tcaagcactc ctcccaaagt ggtgagatta caagcatgag ccactgaatc 111000 cagctttaat ttttttttag caacacacat gtaaatgtcc ataagataaa ttgtttataa 111060 tttatcagaa agaatgtaac aacaactatt acaaatcaat gtctaatttt attatggcag 111120 tgtccaataa cctatcaaat aactcttaag atgccaaaaa aaaattttaa gcaccatttc 111180 actaaaaatt aacttaaggc caggcacagt ggctacccct gtaatcccaa cactttggga 111240 ggccaaggca gccagaccgc ttgagcccag gagttggaga ccagtttggc caacatggcg 111300 caaccctgtt tctacgaaaa atacaaaagt aagccaggtg tggtggcaca cgcctgtagt 111360 cccagctact cgggaggctg aagcaggagg attgagttca gaatccggaa gttcgaggct 111420 gcagtgagct gtgatcacac cactgcactc cagcctaggt gacagtgtga gactcggtct 111480 caaaaaaaaa aaaaaaaaaa aaaaagcttc aaaaaattcc aggctgggcg cggtggctca 111540 cacctgtaat cccagcactc tgggaggcca aggcaggggg atcacctctc tactaaaaat 111600 aaaaaattag ccaggcgtgg tggcacatgc ctgtaatccc agctactcag gaggctgagg 111660 caggagaatc gcttgaacct gggaggcaga ggtcgcagtg agccgagatc atgccattgc 111720 actccagcct gggcaacaag agtgaaactc cgtctctcac acacacaaaa attccaggaa 111780 agcatgatat caaaggatat cctaactctt atagtctgtt tcccattctg tcactgagct 111840 gctgttagtt cctttcacct gagtttattc catgtgaaaa ttgaagatat tattcagact 111900 tcaacagagt gctccagaaa tatttatcaa ctgctgtaaa cttcactaga aatgctaaag 111960 aaatgttaaa aaaaatctta tcaatacttt acaaagaaaa taataccatc aacaaaaagt 112020 gtgcttacct attcacaaag atatagagcc ttactagcaa atataaaaat aaaattgctg 112080 tttgtgacta tgatcctaaa gtgtaatgtg tttttttttt tgttttttga gatggagtct 112140 tgctctgttc cccggggttg gagtgcagtg gcataatctc ggctcaccac aacctccgac 112200 tcccaggttc aagcaattct cctgcctcag cctcctgagt agctgggatt acaggtgtgc 112260 accaccacac ccagctagtt tttgcatttt tagtagagat ggggtttcgc catgttggcc 112320 aggttggtct tgaactcttg acctcaggtg atctgcccac ctcagcctcc caaagtgcca 112380 ggattacagg catgagccac tatggccggc cagattccta aagtgtaatt tcaaagggcc 112440 acaaaacatt ttttttagac agggccttgc cctgtcaccc aggctggact gcagtggcat 112500 gatcttaact caccacaacc tctgcctcct gggcttaagt gatccttctg cctcagcccc 112560 cagagtagct gggattacaa gtgcatgcca ccatacctgg ctaatttttt atctgttttg 112620 gtagaaatag gcttttgcca tgtagctcag gctaacaaaa atatttcaca ataaaaattt 112680 aatttactaa tttcaaatgg gggtggggag agaagagtag ctaccaaatc agctttaacc 112740 aaattcagct agaaatcaat gctttaggcc aagcgccggg aggcagaggt tgcagtgagt 112800 tgaaatcgca ccactgcact ctagcctggg caacacagcc agactccgtc taaaaacaca 112860 aacacaaaaa caaacaaaaa accagattgg ccaggcatcg tggctcacac ctgtaatccc 112920 agtacttgag aggcagaggc aggcggatca cctgaggtca agagttcaag accaacctgg 112980 ccaacatggc aaaaccctgt ctctaactaa aaatacaaaa attagctggg tgtggtggca 113040 ggcccctgta atcccagcta ctcgggaggg tgaggcagga gaatcgcttg aactcaggag 113100 gcagaggttg cagagagcca gtctgggcga cagagcgaga ctgattctgt ctttaaaaaa 113160 ggaagataaa gtgtttaaat cattattcaa gtgaaaggta tcacaatcat tgtggtaaaa 113220 tttgttttat tgataaaaaa attaacaaaa ttcatatact ataaaataag gttaataata 113280 aaaaataaat cagtgcttta agagcatgta atttaacatg attcctttaa aatacacaag 113340 tgaggccagg cgctgtggct catgcctgta atcccagcac tttgggaggc cacggtgggc 113400 agatcatgag gtcaggagat caagaccatc ctcgctaaca tggtgaaacc ctgtcgctac 113460 taaaaataca aaaaattagc caggcttggt ggcgggtgcc tgtagttcca gctactcagg 113520 aggccgaggc aggagaatgg cgtgaaccca ggaggcggag ctggcagtga gccgagatcg 113580 cgccactaca ctcagcctgg gcgacagagc gaagactccg tctcaaaaca aaacaaaaca 113640 aaacaaaaca cacaagtgaa acaaccgttg tcacaatttt atttgggtgt gaaatatgga 113700 ccatcatcag taaacattaa attcaaacta cgtgttaaac atggctgggc acagcggctt 113760 acatctgtaa tcccagcact ttgggaggcc aaggccagag gatcacttaa gcccaggaat 113820 ttgagaccag cctggccaac agtgagacct catctctaca aaaaaaataa aattagccag 113880 gcaagtggcc acgactgcag tgagctgaga tcacaccatg aactctcatc tgggcaacag 113940 agtgaaatcc tgtctcaaaa cacacacgtg cgcatgcgct caaaacacac acacacacac 114000 acacacacac acacacacac gcacgcacgc acgcgcatgc gcaaacccta ccacatgatc 114060 tagcttagcc aagagaaaaa aaagcgtata tccatacaat gttcatagca actttactgg 114120 taatagccca aaactggaaa taacccaaat gccaccaagc attaagaggt gaatgcataa 114180 acaaattgtg gtatatccac ataatagaat actactcagc aataaaaaaa aaatgaacta 114240 aataacatgg gtgaatctca gaattataag tgaaagaacc cacacaaaaa gagtatgtac 114300 tgaatgattc cgcttatata tacaattcta gaaaatgtaa aataatctac agtgacagaa 114360 atgagatcaa tggttggaag ggagggaggg aaagattaca aagggccaca agaaactttg 114420 ggggaagata aatatgtctc ctctcttgat aaggataagc ttcatgggtg atacataaaa 114480 ttaaaactta tcaaaagtat cactttaaat atgtacagtt aactgtatgt caattatacc 114540 tcaataacaa aaaagaatcc aagatgccaa aactaattct acagttcctg ttagatctat 114600 ctgctcataa atatatttaa cctaccgact tgcagtatgc actctgagaa tacaaaatta 114660 tgcctaaatt gaggatcacc attatcacaa aaaacatcaa agtttaaaca atgaggaaat 114720 tagaattcat ctttaatcac tatgccaggc tatttcagtg ccaaaacgat accaactaaa 114780 acacaacaca acaaaacaag agcccgctga gtgtagggct ctgagatttt taattaaata 114840 ttttaattca aatgtttacc ttctttgatc tagaatccca tttcgggaaa acagaaataa 114900 cccaaagaaa agcctatgca caaagatgtt aatttcaatc ttattcatca gagaaaaatg 114960 gcaaagaatt aaatcaatgg cacagccatg ggatggcata ttacatgagc tacttttttt 115020 ttttttgaga ctgagtttcg ctcttgttgc ctaggctgga gtgcaatggc gcaatctcag 115080 ctcaccgcaa cctccacctc ccaggttcaa gcgaattgat tctcctgcct caacctccca 115140 agtagctggg attacaggca tgcgccacca cgcccagcta attttgtatt ttttagtaga 115200 gatggggttt cttcacgtta gtcaagcagg tctcaaactc ctgacctcag gtgatctgcc 115260 cacctcagcc tcccaaagtg ctggatgtat aggcatgagc cactgtgccc agcctagtca 115320 ttattatttt tttttttttg agacgaagtc tcactctgtg gcccaggctg gagcacagtg 115380 gcgctatctc tgctcactgc aagctccgcc tcccgggttc acaccattct cctgcctcag 115440 cctcctgagt agctgggact acaggcgccc gccaccacgc ccggctaatt tttttttttt 115500 tgtattttta gtagagatgg gtttttacca tgttagccag gatggtctca atctcctgac 115560 ctcatgattt gtctgcctca acctcccaaa gtgttgggat tacaggcgtg agccaccgcg 115620 cccggcccct agtcattatt tttaactggg aaaaacagtt gcaaaaatat taagcaaaaa 115680 cagggcagac acatacagta tgatcaacag gttgaaaaca atacatcctg gggagaataa 115740 aagatatagg aaaaaagcca taaggttaac atttaaggcc aacagttctt aaacagtggt 115800 cctggaccag aagcatcatc tgcgaacttc ttagacccca ccctagaccc aatgaattag 115860 aaaactccag gagtggtatg cagtaacctg ttttaacaaa ctctccaggt gattatttgt 115920 tttttgtttt ttgagatgga atcttgctct gtcccccggg ctggagtgca gtggtgcaat 115980 ctcaaactaa agtttgagaa ctactgttta aagaactagg attacaggtg actggttttc 116040 cttcttgtaa cctatgtttt tctcaattat ctttttactt ttgaaatcca actaagttct 116100 tttaagtatt ttactaacag gtacactctg taggtctaca ggtaaaaagc tattacgttg 116160 caaacattat aacgtaatgt aaggtctgga ttacatgcct aaaaatccaa tgattcttgg 116220 aaccatcaaa tctgttaaga ctgaaaagaa taccaatgtt taaatatatc tataaaatgc 116280 aggtcaaggg gctaagaaaa ttgcaacact agaaaaccaa caaacttagg ttgttctaac 116340 atacatacac aaatacagga gggacgttta tgggtcacat ctgcgaaaca ttttttccca 116400 aaaagctgaa tttttaggct tgcgtgtaat ttactagaac tgcactgcag gaatcagatg 116460 ttctgaagct gtgaatgctt actcatgtag gttcctgcct aaccaaaata agtaccagta 116520 tgttatattt gtcaccaaaa tctaggcagg gaagacaaat tcagaacact gagagttgcc 116580 aaatctttaa cttttagctt gaagaccata aagctgtgcc aactttcatc tcatcatctc 116640 actaaaacag agtccactgg aaataaagag gcaaaccaca ggttcccaat tgacactaga 116700 actagttaaa agatttaggg aactgtctac cctttgaaca caaattaaag agtaacaaag 116760 actactaact tagggataga gtaactactg attaacagca aaataccaaa gttaagtcaa 116820 agacaaatgg ctacatattt taatatttta gttttgaaat ttttttaaac aggtgtacag 116880 atccccatat acatcctagc acacaaaatt cattttaacc tttctattcc ttgaaaagtc 116940 cactctaagt aaatacaagt tactcaaaaa ggcactacac acagcaatga cctaacacag 117000 cctgtccttt ccgactaaaa aagttttaac taattgcata agcaccatga ccacccatac 117060 tgaatttttc actactaaac tcccagcaca atgctggcac aaagcaagta cccaaacata 117120 tgaggatttt ttttttttga gataagagtc ttgctctgtc gtccaggctg gagtgcaatg 117180 gtgtaattta ggctcaccac aacctccgcc tcatgggttc aagctattct cgtgactcag 117240 cctcccaagt agctgggact acaagcccgc accatcacgc ctggctaatt ttttatattt 117300 ttagtacaag tacatacggg gttttgccat gttggccagg cttgtcccga actcctgacc 117360 tcaggtgatc tgcccgcctt ggcctcccaa agtgctggga ttacaggcat aagccactgt 117420 gccagctttt tttttttttt aattaagaga gtcttgctct gttgcccagg catgagtgca 117480 gtggcatgat cttagctcac tggaccctca aactcctaca cttaggtgat cctcccgcct 117540 cagcctccca aaatgctggg attacaggtg tgagccacca cacttggcca catctgaggt 117600 tttgaatttg ttagagaaag cttctgaaac cctaaagcag acaccaacga ttctgtaaaa 117660 ttaactcagg ccgttttaat gtaagacacc gtccctttct atcacacttg acgctttctt 117720 aagggaagct gacatttctg ccatactttg gaatccctgc aaatgagtca gttaagtgca 117780 tttaaagtgg catgccctgg gccaggtgca ctgggctcac acctgtaatt ccagcactct 117840 gggaggccaa ggcaggagga agatttgagg ccaggagttg ggaggccagc ctggtaacct 117900 agtcagacct cggtctctac aaaaaatgta aaaataaata agggggggat cctattactg 117960 aactccctct gaaaagaaga atcattgaaa actcttggta ttgtaagtta caaaattgta 118020 catatggtgt atgccggtcc ccattattat ccgatctact tttctgattt aaccttaatt 118080 tttctaaaca tttcttgtac tctaacaggt caggttttcc tcttctcttt ttacccctcg 118140 aaaacacact tgttcctgta acaccactca gagggcctcc ccagccccca cctcttttgt 118200 atataaacac actctcttgt cacatactcc atcagctgtt tggtagctcc tcccctcctc 118260 cttttccggg tagtaacagg gcggccaatg agcgctgagg agcggtgcct gcggcctttt 118320 gcctgcatac gcttttccaa aacaagcagc tctagccttc agcaggggcc actggttcac 118380 agatgaaagg atcaccaggg ctgtgcaaca gggtgagacg agtaaccccc accaacaagg 118440 aaacccgtgt aatctgagct gtttgttcct ccaccaggga gaacttaaac cgatattcct 118500 ttagggcaaa tcacgcttta aggtcaccag agccccagct ctcagacaat ctaaataatc 118560 agctggttgg aggtggaaac ctcaaaggtt gccaggctct gggcagcaca gatcaccaat 118620 ctacctgact ttgcaaacaa atggccgcac tattcgagac tattccatag gatctgggct 118680 aactgcaagg tttttttact gggacacatt cctaaaggat ccaaaagtca tgtaaatcag 118740 tttctaggct cctggggagg tttgcacaac ccttagcaaa ggatcagaag agaaacaatg 118800 aatgagtcag agtttcagaa cataatcacc cagcagatta ttaagtgcat tggtgcaaaa 118860 cactcactcc ctgcataact tgggagtcag ctctcctacc aacccgtcac aaaagaaata 118920 tcactgactc caaacaacaa ccagagacgg tgtctccaaa agaaccgagc gaggtggtgg 118980 aaggcagcgg ccaattagtt acacatcctc ttctctccct acccccacac tgctactttc 119040 ctactatata ggttccctgc caggctgtaa atcgtggtgg tataattacg ctcaggagac 119100 atccaaaaat gggctgaaac aggagactgc aaggaaacca gctatcgccc cccacaccaa 119160 agaaatcatc aaggggcatg gggggcaaga agtgcattcc ttcagacctt ttcttcctac 119220 ttcctctcca ccatctttct caacccccag ccttttcaca caattgtact cattttagta 119280 gagggctggg gaatttttcc ttaaattttc tgctaaatat accttactca aaaattgttg 119340 gctccatttg ggcctactga tctgtgaatt caacagagaa aggaggacac aaaatctctc 119400 acctacacaa cacacacaaa aggaaatccg aaacatttta acttccaaac tccattatac 119460 cagaaaataa acacgaaaca aagataacct ctggctttta aatctcgaaa ctgttatcct 119520 cctatctcag atctacaatt ttaaagcgcc tctgctttct tttgtcagaa aggaaggaag 119580 gtggggaaag aacagaaggc caatgcatct ttgcctttct tcatcttcta ctaaaaataa 119640 gctatgaaat aagccactta gggggagaaa aaaaagacac cctgctgttc tttgtctgtt 119700 ttcctctccc tctccacccc ccacaccccg actcctaaat gcggtaatca ttctagatgc 119760 cacaactact aaatgaacaa aaggcactgt atggaaaagg catcaggtca agttaggccc 119820 ccctctttat cctcaatctt ttaaaaatat gtctatgtac ataatttgag actctgacaa 119880 cgatcacaaa cagctggaat tgtctcccca ctccatccca attaaacatt aggtagaaat 119940 tcgcattagg tgtgacagta actctcaatt caagataaaa ataactcaga tgctgccact 120000 atgtcatttc ctagtttcta aacaaaaata aaacccgaaa ctgctttgtg taaaatgtac 120060 acacagtcat agttacaagt tttcctgcag ccttatgaaa agccaacatt actggtatca 120120 ttcacacatt tacaaaacaa tcacagccac aaacagctca taaagagttg atttcacttg 120180 cgcctgaaca tatattgggt acactatact ttattagttg ctccgctcta atctcccact 120240 cccccaaaaa ttctaaactc caaaccacaa acttagaagt ctatctactg ctcctaattt 120300 ctaaccaagt tttccctgag caaggagaaa aacaccttat ttctgaaaag attatttttt 120360 aaaaatctct tgcccagaca acttccctcc catcccccac tgccaaacca tatgcaaaaa 120420 ctactttttt aaaacttcag caaattccct aactgaattt tttgacaata accactgatc 120480 tctacaaaga ggtaaaacac tcaatcaaaa acagcaacaa ataaaaggaa gaaaaaaggt 120540 attcacctga agaatttagc caaacaactt gagttatata aacaaaaccc tgcaacaggg 120600 ggaaacggtg gggggatggg gaggagggag agaaacagga gacaggactt ttaaactgtg 120660 ttccacacta ccaccctcta agcccccact tgcccccctc cccaaggact agctgttcag 120720 aactctgggc tccccctacc ctctaaacta cccttcaaaa aaaaaaaatt ctcgatttgt 120780 cacaggaacc ttcgcgaatt tctctagctg gtcctgaaat aatcagtctg gactccaacc 120840 aaaaccactg cctgaagggc tcttatcagt tatagctttc ccactgcaac ctccagagtg 120900 cataaagttg gggggagggg gcagaaaata aagggtgtca cttggcgaca tcagggcaag 120960 tattccccca agaacctgac cctcacagag gaagttttgc ccaagtggcc agtccaggga 121020 ctatttattt tgtccaggag ctcctctttc cccagctgtc atacccacaa tatggagggt 121080 ggcttgctgg agggcccggg ggtcttcatc acatacaact atgggtggga caggctttgt 121140 cagtggaaag gaaaacagta gggttctccc ggggaccaga aagcttaaca ggagggactg 121200 actgaaaaca cacagagctc tttcttagaa gagggggccc tgagcaggag actctcttcc 121260 taatatagaa aggaattagg gataaaagag gtcgcttgag tgaccccagt tcaagcagca 121320 ttgtggttgg aggaaatggg ggcatctcaa gaaacggaga aaggcttccc tctcgggaat 121380 ttctgccttg attccctaaa tccaaagcga gcaaacagga gagagaaacc ctgaaaatgg 121440 gctcggtggt agagagtgag gcgactggtc gtgcaaaaag aaaaaaggcc gtctcgggag 121500 tccaaacgtc gcggaggaaa gtcacaggct ctggggatac aggaagagcg agcagcaacg 121560 cgtatttcgg ggtgctgcgg agaaaaggcg agctgaaaag gctctcggcc cctgggaggt 121620 gccaaggagc cgccgtaggc actgggggag gaggggagtc tcggacagtg gcctggagtg 121680 ccccagggcc cttgcagtgg ttccgggggt gccctgggca tccccacacc gccccccaca 121740 cacagcccga attcccctcc acgaaggata cagcttgacc acgtccgtgt ccatccgcct 121800 cttgcccgga ctgggagatg acatggtgtc gccgccgcct ctctcccttc ctcggcccgt 121860 ctgtcacggg cccggggccc cggctctgag gagcccgcgg ccgcgccggc tcctcggtgg 121920 aggtggcaac acccccgcgg tcccggcggt cccgtcagcc gccgccgccg ccccccgcac 121980 gggggaacac cgggcactgt ccggccgggt gggggtgggg accctgcggc gcccggctcg 122040 ggctgcccct ctccggctgt ggttccgccg cggccctgcc ccggcgctcc tctgcgccgc 122100 gcgacgctcc ctcctgcctg ctgtggctcg ctcgcctgct ccccactcac cctctgaccg 122160 gctcctagca gcctccacta taagcggacg actcctgctc agtcggcctc cctacccc 122218 <210> 32 <211> 14324 <212> DNA <213> homo sapiens <400> 32 ctagtgacac tgggcccgcg attccttgga gcgggttgat gacgtcagcg ttcgaattcc 60 atggcggcgc ggcggcgacg gagcaccggc ggcggcaggg cgagaggttc ggagctcaat 120 atcgcgggac ggcatgcggg gggcgggcag tcagaaagga acgatgccac ctactgtgac 180 ccccttcccc ttccagctcc ctataacctg cacttggcta ccaaaccagt tggggtgcta 240 aattttgtaa atttcggttt tcagagcttt ggggattaca taattgtgca taaagccttg 300 cggagctgta acaactaatg tgccagtact gttgttaata cctaatgtca tccaatttac 360 aaaaagtaat tgtaaggcac accattattt tatacacaac aaaggataag cactgaaaat 420 ggtgaactgt gattcactgc ttatgtcatc cattgtaaga tgcatcccag ttccagagag 480 taaaatgcga gtcttagacc tattgagata cggtattatg tgtataatgt tcttaaatgc 540 ataggtgcac cctataaatt aggttctatt gtacttctct agaagtacag tattgtacaa 600 tattctaata ttggagtaag tgaagtagga agagatcaaa tacttctcca agtttccaca 660 gagaaaagca gcagagctag gctctaaatt aggcacagac ccttgagcac ttaactaacc 720 tttatcccat acggcctcat gtatgaggtg ggtatttggg ggacattggg acacaagtaa 780 aacagataag caggcctcaa tctatgagct tacaagactc ctgggactcc cttttatttt 840 gttttatttc atttggctag aatagcaatt taggaagaat tacacagact gttacacaaa 900 agtagtgtgg gacagttgtt attgcctctg taaacttaga aaattatctt aaaccggcgg 960 ggtgaggtgg ctcacgcctg taatcccttg ggaggccgag gagggcagat cacttgaggt 1020 cacgagttcg agaccagcct ggccaacatg gtgaaaccct gtctctacta aaaatacaaa 1080 aattaactgg gcatggtggt gcacgcctgt aatcccagct actcaggagg ctgaggcacg 1140 agaatcactt gaacccagga ggcggaggtt gcagtgagcc aagatcgcac cactgcagtc 1200 cagcctgggc gagagagtga gactccacct caaaacaaaa aaagagagaa aattatctta 1260 aaccatttct ttaaaagatt tttttcaatc tttaaaatct acacgtattc gggtgtgtac 1320 tcattctttg ctaatttcca aattctgtag cattaaatga aagcaaaaga gttaataatg 1380 gcaacacggc tccagaagac tcttcccctg ccaagaaaac tcgtagatgc cagagacagg 1440 agtcgaaaaa gatgcctgtg gctggaggaa aagctaataa ggacaggaca gaagacaagc 1500 aagatggtat gccaggaagg tcatgggcca gcaaaagggt ctctggtagg agtggatctg 1560 gggatgatat cttgttattt caactcctat ttcgtccttc tttcagggaa taattaattt 1620 ctctatcctt tgggcatacc acagcactaa tctactgcct tgaatcttca ttttcatgta 1680 tttgagatgg attggggtct aaggaaagac caggattggt tgggcgggca aagttaatcc 1740 tgacaagttt ctgttttacc acaacagctg tttttgattc ccataaagta gtacctatct 1800 gtctttcctc agaatctgtg aaggccttgc tgttaaaggg caaagctcct gtggacccag 1860 agtgtacagc caaggtgggg aaggtaagag actctggaac cgatcttcag tccatggata 1920 tctcagagag catcctttgt tataaggact cctgtctggg atgctgttag tactcatttt 1980 aggaatcctc tccaaaatat gatgagtgag tagttttctc taatggcaag agataggagt 2040 ggtagggctt ggggttaata atcagggtgt tttttaacat ggtgtgttag accattcttg 2100 cattgctgta aagaaatacc tgagactagg tattttataa gaaaagaggt tcctagaggc 2160 tgtacaggaa gcatagcagt atctgctcct caggagacct taggaaactt ttactcatgg 2220 cagaaggtga agcgggaata ggcacgtcac atggcaaaag caggggagag agagagagac 2280 agagagaaag ggagagagag agattggaga aggtgtcaca gagagagaaa gagagaatgg 2340 ggaggtgtca cacgctttta aactaccaaa tcttgtgtga attcactcac tatcaagagg 2400 acagcagcaa gacagtggtg ctaaaccatt catgagaaat ccacttccat gattgaatca 2460 cttcccacca ggccccacct ccagtactga ggattacaat tcagcatgag atttggaagg 2520 agacaaatat acaaactata tcacatgcgt accttttgtg gttgccatca gccttctaca 2580 cctcattctc tttttaaacc agaaaatggt atcattgtta agggaaaact gttttcttgt 2640 tctaatgaga aactgtaccc tggaatggca tgagttactg atgaatgggg aaaaaagaag 2700 gctacctctg gaataagttt tctttaactc agttagaatc tttttttttt tttttttttt 2760 ttttgagata gagtctcact cggtcaccca ggctggagtg cagtggtgtg atctcagctc 2820 actgcatcct ccacttccta ggttcaagta attctcttgc ctcagcctcc caagtagctg 2880 tgattacagg tgcccaccac cacgcccagc ctgggctaat ttttatattt ttagtagaga 2940 cggggcttca ccatgttggc caagctggtc tcgaatgcct gacctcaagt gatctgccca 3000 ccttagcctc ccgaaatgct gggattgcag gcatgagcca ccatgcgcag cctaactcag 3060 aatcttttgt atagttaaaa aaaaggaagc atgttttcat ttatagtaag gttacaccca 3120 ggttactggt agaacatagg tttgcaattc tttccttggg agatgaatgt tgatgttgct 3180 gtagaatgat gacttgagcc ataagaaaat ttagagcctc atttaggatg tcagggctga 3240 acctatacta atgttgattt tttctctctc tccctttcta ggctcatgtg tattgtgaag 3300 gaaatgatgt ctatgatgtc atgctaaatc aggtaagagg caagaagagg tggcaccatt 3360 atatttatga gaccatcttc ttgataatta ttgatgatag catcacagtg ttcagatctt 3420 taaagtccct tttttttttt tttttaaatt ttgttttttc tttttgaaat ggagtctcac 3480 ttcatctctc aggctggaat acagtggcac aatctcggct tactgtaacc tctgcctccc 3540 aggttcaagc aattctcctg cctcagcctc ccaagtagct ggggttacag gcgtgcacca 3600 ccactcccag ctaatttttt gtatttttag tagagacaag gtttcgccac gttagccagg 3660 gtctggtctc gaactcgtga cttcaagtga tccacccacc tcagcctccc aaaatgctgg 3720 gattaccagg tgtaagccac cacgccttgc ctaaagtcct tcatatgtgt gtgtgtatat 3780 atatatatat atatatatat atatatatat atatatattt tttttttttt tttttttttt 3840 tttttttttt ttgagacaga gtcttgctct gtcacccagg ctggaatgca gtggtgcaat 3900 ctcggctcac tgcaatctct gcctcctggg ttcaagcaat tctccagcct cagcctccca 3960 agtagctggg actacaggtg cagtgtctgg ctaatttttt ggtattttta gtagagatgg 4020 ggtttcacca tgttggccag gctggtcttg aacccctgac ctcaggtgat ccacccacct 4080 caccctccca aagtgttggt attacaggca tgagccactg cgcccggcaa gtcctttata 4140 ttaatattag ccattagtgg ttaaacacct gagtactcag ccctagcaca ctcttatcag 4200 atagcagagt cctctgtgag aagatttttt tttgcaaatt tcatatcatt tattgaaatt 4260 gttaactctc tgttcatatc cttttgcaca tttttttttt ttttttaaac agacaggatc 4320 ttgttctgtc acccaggctg gagtgcagtt tgtacagtca tagcccactg caaccttgaa 4380 cttctgggct ccagcaatcc tcccacctaa gcttcctgag tagctcggac ttcaggcgca 4440 tgccacaaag cctgactaat ttttaaattt tttatggaga tgagaatctc gctatgttgg 4500 ataggtggtc ttgaattctt ggcctcaaat gatcctcctg ccttgtcctc atgaggcact 4560 gggattacag ggatgagcca ctgggacaag ctgttttgca cattttctaa agttattggt 4620 ccttttctta ctggtttcga ggaactttat ataatatgga gaatagcctt ttgtctgtaa 4680 tacaaaccac ttgtgttttc cagatttgtc atttaccttt tggttttcct tatagtacac 4740 tttttgccca tattgaagtt ttaaattttt tctgtagtta aatttattaa tttttccttt 4800 ttaaaaaatt ttgggttttt ttttttttaa ttttagagac agtgtcttgc tatgttgctc 4860 aggctggcct tgaacttgtg acctcgtgtg atcctccaac ctcagcctcc caagtagctg 4920 ggactacagg catctgcccc caagctcagc tttcttttta atcaaccttt ttctcttgtt 4980 tacctttgtg gttttgagta gataatacat ttgcctcatt aatatatttc ctggatatga 5040 cttcatgttt gaatttattg atccaacata tataatttta acaaccaatt agtatttatt 5100 tcttactatt tcttctactt aaaataccac gagcagatag aaaatacctt aaggttagcc 5160 aggtgcagtg gctcacgcct gtaatcccag cactttggga ggctgaggcg ggcggatcac 5220 ctgaggtcgg gagttcaaga ccagcctgac caatgtggag aaatcccatc tctactaaaa 5280 atacaaaatt agccaggtgt ggtggcatat gactgtaatc ccagctactc gggaggttga 5340 ggcacgagaa ttgcttgaac ctgggagacg gagtttgtgg tgagccgaga tcgtaccatt 5400 gtactccagc cctgggcaac aagagcaaaa ctccttctca aaaaaaaaaa gaaaagaagg 5460 aaaatacctt aaggcagcca ggtgtggtgg ctcatgcctg tcatcctagc actttcggag 5520 gccaaggctg gagaatcact tcaggtgtga gttcaagatc agcctgggca acatggtgaa 5580 accttgtctc tacaaaaaaa tacaaaaaca ccgggcatgg gccagctact ttggaggctg 5640 aggtgggagg attgcttgag cctgggaggt tgaggctaca gtgagctgtg attgagccat 5700 tgcactccag cctgggtgac agagggagac cctatctcaa aaaaataaaa aataaaaacc 5760 ataaaaacat ttacaaaaaa attttttaaa ggaaaagaaa atatcaagct gggcatggtg 5820 gcttatgcct aaaatcccag cactttggga ggccaaggcg ggcagatcac ttgagttagg 5880 ggttcaagac cagccttgcc aacatgttga aactccatgt ctactaaaaa tacaaaaaaa 5940 aattagtctg gcatggtggc gtgtgcctgt aatcccagct actagggagg ctgaggcaca 6000 agaaattgct tgaacctagg acacagaggt ggcaatgagc ggaggttgca ccactgcact 6060 ccagcctggg cgacagagca agactctgtc tcaaaaaaag aaaatatctt aggctccttt 6120 ttgttctaac atctaatgac cttttttttt tcaccagtgg gctaaggtcg tacaatggct 6180 ttagaatgtg agcaagcagg agatagaggt aggaaggggc agcatgctta acaaaaaaga 6240 atgcctccat atccagggct cggccataca acaccagctg ctatgcctta tcatggactt 6300 ctctctcttc actctgagtg atttacttac agatacctct ttttagatac tggccatatt 6360 ctctctcagt atctccaagt caggtcaggt taggtatggg acggatgtgg cagtggtttt 6420 gcgtatccct tgtcccctcc cattattgcc ctgctctcag ctcattgtca aatttctgca 6480 gctgacaaac aaaagctgtg agtagaactg tcaaggagta agtcatttaa cagttgagca 6540 taacaggttt agacctttgg agcatccaaa ttgttttcat ttgggaaata attattggga 6600 gtggattggg agctggaaaa cacatatagc ttagaaaata tctaaatagg gagctgaggc 6660 aggaaaaaac tggaggagcc attcaatgta ggatatttga ggttggatag agggttttag 6720 gaagcttcta ggctcccact ttaattccta agaatccaaa gtttaatgta taagccctat 6780 ttcttcttta tatctttaat cttacaggaa tctaattttc ttgcctgatg ctatcctttt 6840 ccttatggaa ataactggca cctgtgacga aggatgagtc attggtttat gtgatttcca 6900 tttgcaaaac tccttttttt tgtttttgtt ttcactcaac atagaccaat ctccagttca 6960 acaacaacaa gtactatctg attcagctat tagaagatga tgcccagagg aacttcagtg 7020 tttggatgag atggggccga ggtaatgatt tttattgaga ttttatgagt tggcattcag 7080 aaagtcagaa gcagcttagt gggtggccaa aggattctct gggtttaaat tgggtcagta 7140 gaggctctga agtctgggag agccttagga atcaagttga gcatcttgaa attggggaat 7200 ggcaggcatc ctccttagag ttcccactgg aaaaactaag agcagcccat tgagtctgaa 7260 aactcttcta tagttgaact gctagtagtg ctcatagact atggcagtta gcaagtaact 7320 tgtatcaaca tgattagttc cctaaatcct ttcacctttc ccttctccct ttcctgcctg 7380 tttgtcagat gttaagcaga gagatcttgg agagctggcc tgttactctt agggaactat 7440 cttatgtgtg gcatttcctt tgcagttggg aaaatgggac agcacagcct ggtggcttgt 7500 tcaggcaatc tcaacaaggc caaggaaatc tttcagaaga agtgagtgct gaaaagtgac 7560 tacaaaaaaa tataccctcc tcttcttaga tgtatattct ctaaaaaatt tttttttaga 7620 cagtttcact cttgttgccc aggctggagt gcaatggcat gatctgagct cactgcaacc 7680 tccacctcct gggtttaagt gattctcctg cctcagcctc cctagtagct gggattacag 7740 gcgcccacca ccacgcccag ctaatttttg tatttttaat agagatgggg tttcgccatg 7800 ttggccaggc tggtctcgaa cccctgacct caggtgatcc gcctgcctca gcctcccaaa 7860 gtgcgggatt acaggcgtga gccaccgtgc cctgccttct ctaagaattt tataagtgtg 7920 tggcttataa aaaacttttc gttttatagg tgtgatttgg cctaaatgtt aatgtctttt 7980 caccctgaca ttctgtggtt gaaacaccaa actgcatcct tagtgattaa atcaaactaa 8040 taccttgaaa gtcactaaaa acagaagaat ctaatatatt taacacatga ctgacaaatt 8100 taggaaattt gggataagtg gagactatcc tgggatagat aatattcaac taggggctga 8160 gcacggtgat gcctgtaatc ccagcacttt gggaggttga ggcaggagga ttgcttgaag 8220 ctaggagttt gagaccagcc tgggcaacaa agcgagaccc ctgactctcc cccaaaaaaa 8280 aggaaagaaa aaaagagaat attcagttag aatttttaaa actttatgat atagatgaag 8340 aactttctgg agaattggag aacatgtttc tttcagggaa agagattaga tggatatctt 8400 ttgtttgaaa tctcaatggc ttttgtggtg tttgggaagg acaagcattg tttttcccat 8460 tttttaaatt ccatttgtct ccagagcttt tttgtccatt tagtgtcctc atttagaatt 8520 agactaattt tgatttatgg aaagttgatg tgtaaaggag ctcagtgctg gaaaataaat 8580 tctttggaga ttttctgtct tgtaagtcca tcttcatagt agacctttat ttgtaaagtt 8640 ttcttacacc ttggactcta cagattcctt gacaaaacga aaaacaattg ggaagatcga 8700 gaaaagtttg agaaggtgcc tggaaaatat gatatgctac agatggacta tgccaccaat 8760 actcaggtaa ctctcactat acttttcgaa agaaacacat cttctttttt tattttattt 8820 tttagaggca aaactgtgct ctgttgccca ggctgggtgg cacaatcatg gctcactgca 8880 gcctcaagat cctcaggctc aagtgatcct cccacctcag cctcctcagt atcaggaact 8940 acaggcacgt gccactctgc ccagctgatt ttttttcttt tttttttgta aagatgaggt 9000 ttcactatgt tgcccaggct ggtctcgaat tcctgggctc aagcagtcct cttgtcttgg 9060 cctcccaaag tcctgagatt acaagcatga ggcaccacac ctactcctgt ttcttcttac 9120 tcagggtaaa gcagaatagc ttagatcatt cctggactgg gacaggccag gatatcttga 9180 atcctttcta cttctcacct caggggtgct ctcactgatc tttgtaatcc caaagggaca 9240 gtaagaatga ggatagaatg tgcctttcta gtcttggctc tgttatttac taaggttctt 9300 tttttttttt ttgagctgga gtttgattct tgttgcccag gttggagtgc aatggctcag 9360 tctcagctcg ctgcaacctc cagctcccgg gttcaagcga ttcttctgcc tcagcctctc 9420 aggtagctgg gattacaggt gcccgccact atgcccagct aatttttttt gtatttttag 9480 tagagacagg gtttcatcat gttggccagt ctggtcttga actcgtgacc ttgggtgatc 9540 tacccgcctc agcttcccaa agtgctggga ttacaggcgt gagccatcac gcccggccta 9600 ctaagtttct tataaaatct taggccctat ttccagacgt ttattgtttt tttcgttttt 9660 ttgtttttgt ttttttttga tacggagtct cgctctgtcg cccaggctgg agtgcagtgg 9720 cgcgatctcg gctcactgca cgctccgcct ctgggttcac gccattctcc tgcctcagcc 9780 tccggagtag ctgggactac aggcgcccgc caccacgccc ggctaatttt tttttgtatt 9840 tttagtagag acggggtttc accatgttag ccaggatggt ctcgatctcc tgacatcatg 9900 atccgcccgt cttggcctcc caaagtgctg ggattacaag cgtgagccac tgcggctggc 9960 accagaagtt tattgttatg gaccaagaga ggagtgataa aaaatcaaac tgattaaaca 10020 attaacattt aaatttgttt tcacttctgg atatatacca ccataaaaaa tttaatttag 10080 ataaactgag gtataccagg atgctgaaac tgtccggaaa cagtcacata tccaaaaaaa 10140 tggagaagtt ttagtctttt ttaagatggg aagatctgag acataatagc tgtctttaca 10200 cactgacgtc atgaggaaag cctttttttt ctagacttat tctgagttgt aaaatgtggg 10260 aggcagaact tggatggtca accctctata tccatggatt caatgaactg agaatcaaaa 10320 atgtttgaaa aattgcttct gtactgaacc tgtacagcct ttttttcctt gcttctcatt 10380 attccctaga cagtgcaata taaaaacttt acaaagcatt tacattgtat aatattgggt 10440 gttataagga atctagagat gatttcttag attgtcttgt gttttgtttg ttttttgcta 10500 taggatgaag aggaaacaaa gaaagaggaa tctcttaaat ctcccttgaa gccagagtca 10560 cagctagatc ttcgggtaca ggagttaata aagttgatct gtaatgttca ggccatggaa 10620 gaaatgatga tggaaatgaa gtataatacc aagaaagccc cacttggtag gacttcacat 10680 tttcttctgc attctctcct tataattcct agctccttta atggatactt tattatcatt 10740 atgatttaaa gcttgctcat agtactgaat gaagaaaatg ggatttgggg tgacaggttg 10800 tatggaggga agaggaacta ttttgaaagt tgaggctggg tgtgatgggt catgcctata 10860 atcccaacac tttgggaggc caaggcaggt ggattgcttg agcccaggag tttgaaacca 10920 gcctgggcaa catggtgaga ccccatctct actaaaaata gaaaaattag ccaggcatgg 10980 tggtgtgtgc ctgtgatcta gctacttgcg aagctgaagt gggaggatca ccggagccca 11040 ggaggttgaa ctgcatttag ctgtgtttgt gccacggcac tcagcctggg caacaggagt 11100 gagaccccat cttaaaaaca ggaaaaaaaa aagttgaaag atgaaagtct tttttaggga 11160 aggatgttaa gtacagttca ctagatggga tcctagtttg gagtctgatc tctgggtggg 11220 cctgcaggga agctgacagt ggcacaaatc aaggcaggtt accagtctct taagaagatt 11280 gaggattgta ttcgggctgg ccagcatgga cgagctctca tggaagcatg caatgaattc 11340 tacaccagga ttccgcatga ctttgggtaa ggcctgtgct gttacttcac tttgttcttc 11400 tacctataca tatcccctgt atccatcagc agcagctata atcttttaaa tcttttattc 11460 ctaagaaaat gatcgtcttg aataggtaca gaaacaaaat gatatatagg tagcctattt 11520 aatcagctta caaatatggg atgcaatctc ccggcttgac cacagccata ttctctgaca 11580 aagtggaagt taccaaccca agagagaatg ggtctagcta tccaaccacc caagtaaaac 11640 accttcaggc atatcacccc cttttcctat ttgagtaact aaaaccacac aaacaccatt 11700 tctgtgaact caagtgatat tagatagaca aaataacatt ttacatttgt tgattctgtt 11760 ttctggttta catccgattt ctatttcttt tatagcttta tagagccccg tgacctagaa 11820 ataaccctga gtggtcaaca ggtctacctg tgcttctaga tagaactgta tccaactgtt 11880 ccctgttgat atcaatataa cttattttta aatgatttta taaaaaataa ttttaactct 11940 agtctcaaaa gtcaaaatcc acatagttca tcttataccg agtatatatt taatattatt 12000 ttatatattt ggaagttaag atctctttac agatctcttt ctctctcaaa tggaaaacct 12060 gtttctcata cctgttttct aaaggaccta tctgtcattt tctattttta gtcatgcgcc 12120 ttttagccac atgtcagaaa gctcattatg ggttatatct ctgttcttag actccgtact 12180 cctccactaa tccggacaca gaaggaactg tcagaaaaaa tacaattact agaggtgaga 12240 tatgtatgat ttgagaagta ttatatccct tataccagtg tcctcccaca ttgattctat 12300 atctcatctt ctcaggcttt gggagacatt gaaattgcta ttaagctggt gaaaacagag 12360 ctacaaagcc cagaacaccc attggaccaa cactatagaa acctacattg tgccttgcgc 12420 ccccttgacc atgaaagtta tgagttcaaa gtaagaaaaa tgatcattta ttttcatatt 12480 cttgcaccct taaccacctc ccccatccca ctgttctcta actacttctt gtcaagagca 12540 aattgtcaat tagggcagac tttttatgta ctagggattt gggaaggcca agcttttcct 12600 agctgccttg taagactgtt tgggagcaga aaggtctgcc aagttatatc agaatcccca 12660 aattcttcag ttcagctcag tctcttgtag agtctacatc agcctttttg tcttattttt 12720 cacaggtgat ttcccagtac ctacaatcta cccatgctcc cacacacagc gactatacca 12780 tgaccttgct ggatttgttt gaagtggaga aggatggtga gaaagaagcc ttcagagagg 12840 accttcataa caggtctgag tctagctttg cgtttggaaa gacactcctt gcccgaaagt 12900 acagctgtag aacttataag agggagtcag aggaaggtgt tggctttttt atgcttatgg 12960 cctatctgtg cagaacaaca gagtacaata atattggctt ttccttagga tgcttctatg 13020 gcatggttcc aggatgagta actgggtggg aatcttgagc catgggcttc gaattgcccc 13080 acctgaagct cccatcacag gttacatggt gagtgaaatt gaactctggg aggagcacag 13140 gggaaaggga tacagtaatg ttctcagtgc tttttttcct agattaggat tagatggttc 13200 ccctccccaa gagttaagcc agctcactga taaccttgtc atctcttact gtgtccctct 13260 ttctttaaat tcctaaagat acctcacctt tccctcagaa ggcggaaatt cacaggggct 13320 tctaccctct ctagaacaga attgtgaggg gaaatggaga agggtctata ttgtgtttaa 13380 gggaatggaa aaacagggtc agtggtatgc accttctctc taacacagtg ggttagaagc 13440 tgaccttggt attcatgtat atatttcagt ttgggaaagg aatctacttt gctgacatgt 13500 cttccaagag tgccaattac tgctttgcct ctcgcctaaa gaatacagga ctgctgctct 13560 tatcagaggt gagacaggag tatgtctgtg atctctagtt tattaattcc agtttttttc 13620 cgatgagaaa agtttgaccc cagaaccaag aggtttacct gggatagctt gagagaggac 13680 caagtacaat ttctagtaca ttggattcct ctgctggagt aggggaaaaa agtactgatg 13740 ggattttctg tttggctttg gagccatcta attcttagta ggatatggga attcaaaggt 13800 tttttgcttt gcaggtagct ctaggtcagt gtaatgaact actagaggcc aatcctaagg 13860 ccgaaggatt gcttcaaggt aaacatagca ccaaggggct gggcaagatg gctcccagtt 13920 ctgcccactt cgtcaccctg taagtactca gaaccaggag gactagaaga ctccttttgg 13980 ccagataaga ctacgttctc tattgcagct tctgaaccag agactgatgt tgacacactt 14040 tttttccatt tggcaggaat gggagtacag tgccattagg accagcaagt gacacaggaa 14100 ttctgaatcc agatggttat accctcaact acaatgaata tattgtatat aaccccaacc 14160 aggtccgtat gcggtacctt ttaaaggttc agtttaattt ccttcagctg tggtgaatgt 14220 tgatattaaa taaaccagag atctgatctt caagcaagaa aataagcagt gttgtacttg 14280 tgaattttgt gatattttat gtaataaaaa ctgtacaggt ctac 14324 <210> 33 <211> 5220 <212> DNA <213> homo sapiens <400> 33 caagctacag ccttaaaatc tgagctcctc aagtgcacaa tttctgtccc ttttaagggc 60 tcacaacact aaagatttca catgaaaggg tcgtgattga ttgagcaatc taggggatat 120 gtgacagggg tttcatgcac tggtacagaa cacaacaggg agtttcacaa tttttttata 180 caatgcttgg aatctacgga taacatcagg ttctaagtcg taagttgatt tttaactact 240 aggtttaggc caggcaggcc cagggctggt ttcaggcctg gtgccgggct gcctgtcttt 300 gatttcactt ccttgttttt ttcttaaaac aggtactgag tataaaacaa tataaaacaa 360 tatgagaagg tctctctctt ccctcaagag tgtatgactt tgctgcccag gatgatcttg 420 aactcctggc ctcaagctat taatttcttc ccaactcagc ctcccaaagt gctgggatta 480 caggcatgaa ccacagcgcc cagcttaaca ggatttttca gagagaaaaa gttttttaat 540 tttaatgaaa tccaccaatt tatctatttt ttcttttacg gcatgtgctt ttggtgtaat 600 gtctaaaaac tatacctacg cctaggttgt aaagatagtc tgttttcagt tttatagctt 660 tccattttac atttagatat atgatccatt ttgagttaag tttgtattac atgtaaggtt 720 ggggttcctt tgttttggtc tttgacaaat ggaagtccac aacatttatt gaaactcttc 780 ttcctccatt ggttttaaga taaatccgtt ggccatactt ctgaatgtct atttatggat 840 tccctatctt attttattga tgtgtatttt tgtctctcct ccatggatac atgaaggaaa 900 gggccttgga cacaaggcag tggggaaagg ggctgggggg ccacacagag aaaggagaag 960 gcactaagat caggctcagc agcttctgga tctgaggcgc cggagattat ttatgggtca 1020 atctggcagc ccctgggcct caggtaggac tgcttagcag tgaaaagggc gtcctgggtg 1080 cagccaacag ggtacagctg caagccattg ttgaaggtgt cttgacgtat cagagaaggc 1140 aggtaaccag gccacatccc tgggcgcccg cgctgtccca ctcccttcct ggtgcgcccc 1200 gcctcgcggt cacaagggcc ccaccgcccg gggagagctg cccaccccgc gcctgacgcc 1260 cagggcctgg aatcgcgctg caaccgcggc ctctttccct ggttctggcc aggtgagcga 1320 ggcctagcaa tctctcccgc atcacaaagg attgggtcag ttaaggctca tccgaaagca 1380 tctgttgagc ccctgggaac agcttagcca aatactgact gcagctacac gttaggaaac 1440 actggtacaa accaacaggc agcctttccg cccttgcgga gggagagact agcatcatca 1500 tcaagagata aaccgaagtg tgctggaaaa cacacgagct ctttagtaag agcaggcgac 1560 atgcaaggaa ccatagtaac aggaacagag gtcctgaggc tggatatgga acccaagttt 1620 gaggatgacc aactgagacc agtgttgctg gagcacaaag tgccaaggag agaaatggca 1680 ggctaaggct ggaatatgca ggtatgaagc gcaacctggg ttcttctgtg ccatgtgaaa 1740 ggttctgctc ttgatcctac ggaaagtggg caaccaaacc aattgttttc caaagatcct 1800 aaacaatgta aagctaggct ttgatcaaag ggctaattaa cccatactta ctatttgtta 1860 acaggagttt cttacatcag atttaaagca gaaggctcac agcttcattt caaccatgcc 1920 actgtatcca tgaaaactct gaaacaagta tttgtggaca gcaaaatcca catgtactca 1980 atacctagct taaattatca aaacacaacc aatcttgtct ctacactaaa ccacttcatt 2040 tgctgactag tctttgaaga catgaaggtc tctgacaacc tcatgagaag atactgaaaa 2100 catcagtctt gtcgtatacc ttatctccct tgcctggcat atacttccat caactaaatg 2160 atccaatgcc tgtattctcc taaacacatt aatgtagaca cattacaaca cagatcctga 2220 cacctttaaa taataaacag agtggggagc aattttgagt ttactattta tcatcttggg 2280 cccctgtaag atggatacaa gaatgtgcat ttccaagggt acctaagata atctatgtgc 2340 aatgaaattt ggtaactgaa gtgttgcacc cgatatggaa aataccaaga ataaaaaaga 2400 aagtatctca ctagaatttc agtgagtttt tgaagttccc ttaaagttct taaagtaata 2460 ctacaatact gcacatttat tccagatcta tcccattttc ttattccaca ggatgaggga 2520 aactgtgcca ggttacaaat gttattaact ctagagaatc ctgaaacaac cctgtcttat 2580 tgtctcctaa aattggtaca ggtcctgcgt ttgctggttt aggataaaaa aaataagggg 2640 gggtggtggt ggtaatgaac atgatcttcg tggtgagaac aggggacagt aagatacaaa 2700 cattttttgg catatgaaaa tttattacta cagtgttttc accattaata tttatgatct 2760 tggtctttcc ttcttgcctt tgtatagggc caaaagagaa acattggcta ctttgacaac 2820 cttaaagcgg actccaggaa tatcaccaac agcatgacct ttgcgaccaa atccagcaac 2880 cagaacttca tcattttcct ggaataaaat aagaagttta tttctggtgt tggtggcgat 2940 cacaaaaata ctttcatgtg aggaaactcc cttgcatcag ataaaaatgt gagggaggcc 3000 accccaagaa cagaaggtac gatagagttg aaatactcac ctcaataaag ttcaagcaac 3060 cgtcattggg tacaaaggct gtgattttct tgccattctt gatcagctgg acccttacac 3120 acttcctaat ggcagaattt ggctgtttgg cttcaactcc tctgaaatac aaaaggcaca 3180 gcactgtgag ctggctttct gaaaaagatt atcttttcat attaactaga gaactaatga 3240 gaaactgttt ctatcttttc aatctaacct caaatggctg agctgaagtc ctgtgatgtc 3300 aacctagttt tctgccagtc ttaatttcat tagcacaatg ggggaaattt ctagaccttt 3360 tacagttata aaagtagact ggagtggcag cgtgggcctg tagtcccaac tacttgcgag 3420 gctgacgtgg gaggatctat gcctagaacg tcaagatggc cagcctgtgt gacaagggac 3480 cctatctcaa aaaaaaaaaa agaaaaaaga aaaaaggtat ctgaggtaag aattagaaag 3540 tctgggccgg acacagtggc tcacgcctgt aattccagca ctttcggagg ccgaagcagg 3600 cattatcacc tgaggtcagg agtttgagac tagcctggtc aacatggtga aaccccatca 3660 ctactgaaaa tacaaaatat tagctggtgt ggtagtgggc gcctgtaatc ccagctacct 3720 gggaggctga ggcaggagaa atgcttgaac ctgggaggct aaggttgcag ggagtcttgc 3780 gctactgcac accagcctgg gtgacagagc tagactgtct caaaaaaaaa aaaaaaaaaa 3840 aaaaaagtct gggttaaaat ggctctacca tcaaatatga tagaactata tgaaattatt 3900 attttaaaaa gtcaaaacca gtcaaatact ggcagtttca tgtctcaatc ttaggtgtat 3960 gacctcaatt aattctgatg caagtcactt ctcttcacct tagttttatc aagtcgataa 4020 agttcaatag ctgacacgtg ccatttactt ataacaactc ccacagtaaa ggtgtttgtg 4080 tcctttactt catcattgct agtatcttct ccaattcctt ccaggccaac gttaaattaa 4140 aaccttaact acctaattcc caaaaactaa ttttaccaac ttttaaatag aacaaacgct 4200 ttgcaatttt accccacaat gcccaaatga atactactac acaaaaacct gcaattactt 4260 tcaaaacaag aattcgtaag ttcatgtctc gaattcctat aataaactaa aacttgacgg 4320 gagcaatgga cttacacttt ttccagcacg attccttttg catgagaagc acctccaaaa 4380 gggttggcct ttagggctgt gcccaaatga gctttcttat actgtttatc atgccacttc 4440 tggtctcgtc ggtgactacg gagcttccta gcagtacgaa gtccacgaca cttgcctaaa 4500 aattaaatat tttagttctt ccgtaaaaac acgccatcta cgtgtttccc atcttctaag 4560 acactcgcct cacctggaat aaacccttaa gccgattggc tctcgtacta tttattggcc 4620 tgtgggccaa acatttggcc ttcaagttgc cctgaaccga ctaataaacg ttcgaagagg 4680 gctccggaga atgtgttctc ccgaaggacg aggccccgct cgaatgcccg ggaggaagcg 4740 ctggcctccc tgcgtccctc ggtaccccga cctcggcggc ctccacgcct catgggcccc 4800 ttccgcgccg gaccacgtgc ctcctggagc ggcgcttccc cggccctccc ccatggagcc 4860 tctccatggc atcccccgcc ctactctatt cgcatccgcc cgcccgtccc caagacccca 4920 agtcccgctt gcagcgccct taaaccggcc acaacagctc acccatcctg tcggcgccac 4980 gggcctgagc gaaagagaga agcaccgcag gaaggagcca caagccaccg cgagcaagcc 5040 ccgcccagcc aaggaccccg cgccgctgtc tgcgccgcgc ctgacccgag gctggggtct 5100 ctcctttgaa aacgacgcgt ttgcatcact ttcctgagcc agaatctgcg tcttatttaa 5160 tttgcaagaa attcagagat atctaatttg catggttttt tttccccctt tttcttttga 5220 <210> 34 <211> 131569 <212> DNA <213> homo sapiens <400> 34 tcggccgagc ccagagacag ccagttcctc tcccgccgcg ccgggccgcg ctgccgctcg 60 ctccccggcc gtggcgcctc cgggccagac gcgctgcagc ctccagcccg cggcaagcgg 120 ggcggccgcg ccacccccgg ccccgcgcca gcagcccctc gccgcgcgtc cagcgttccc 180 ggccagcagc ctccccatac gcaggtcctg ctgggccgcc ccgtcgcgcc ccccactctg 240 aactcaagtc accgtggagc tccgccgccc cgaaactttc accgcgagcg ggtgagtcct 300 ctgcgcgagc ccaggggtgg gcgcgggcac gcgggcagtg ggtgcagggg ccgcggctgt 360 gccaccagcc ggagtcccgg gcgcagggta gactcggggc cgggggcatc ggcgcggccc 420 gcggcggctt cctggccgca ccgcctctgg gctccggcgg cgaaggctct tagatgtctt 480 cagccgacgg gtgaccgggc ccgggggagc cagggcgcgg ggactgaggc tccgcaggtg 540 tccgccgcgg agccgcgcag gggagcggtg ggaggtgcgg gcgcgggggc gggctcaccg 600 cgtgtccttc ccggtgaggg cccgagggcc ggctgctgtc cctgctccgg ccgcttctcg 660 cacacagtgg ggaagccgct gcccttgcgg agcgggcgcg cggcggggat actggagagg 720 actcctcgga ttgtgcaatc tgatctcccc tctggaccct gggtctcctg gcagtgggag 780 atggggctcg gccggcgccc tctcgaggcc cgcggacagt tgccctccct ggtggccccg 840 ggcaggagcg tgacgtcgag gggctgcagc ggaggctgga actcaccctc ccgctgcggc 900 gcctctcggc ctgccgagga gcagtccggt gcttttgccg gctgagagga agcgagagtt 960 attttaagaa ttcaggggtt gcctttcctt cgccttgggg gaagggcgta agagtcagtt 1020 cccactttcc tgcattctct gggcccatgg tggcatcttt tgcttgcggt gcattcgtaa 1080 ctttccaaca gcctgcctgt catgtggatt agcggttgtg tttttgtata tccgagtgtg 1140 ttaattatcc caaattcgcc cttcttcgcc agctcagaat ctaggccttg cacttttctg 1200 gctgtatatt taggggaccg attattgaaa ttccctgttt gagtttcttc atctttgaga 1260 gagcatatat acctcagggg ctgtttagta cacacaaagc ccctagtacg taccaagcat 1320 ttcataaacg atgttactgt tatttattgc agtgaattct attcatataa atgaggcttc 1380 ttggttcttt gcagcttggt gatgttgaag ctaagactac catgtcagat ttagccatct 1440 gaccttatta gtaaatctgc ttaataaata catgagggat ttgctgtccc aaagcagggc 1500 ccagtagtct gactttccct aaagaactag ccaataaact ggtgggctac agggatgttt 1560 tctctgtaca gccaacacct aaagccatgc cctggggaat aggcactgca agaacccagg 1620 ccttactaag cccttctctg taagagtaag ctttgttggg aaagggtggg atccagttag 1680 tccctccatt ctcatttgga ggtaagcagg taagcgcttt gaggcctgaa taaatttcac 1740 tggatcatag agtctttggt gactgggcct ctttggatgt aaatgtgtgg cccttttgct 1800 gagtgaagga tagagggcag cagatgtaag gggagagaaa gtaggagcca ggaaccttga 1860 gttttggcct cttccatcat ttaatatgct gtgatttggg ataagccact tgggccattt 1920 attcagccaa gatttccttt atagcagcag ccagagttat attgatttgt ctgcaggttg 1980 atagtctgta ttaaccatta cagtggaagc tccatgaaaa ctgcttcatc tgtcttgtcc 2040 aaaatgatag ccccagtgcc tggtacatag taggtgctca gttcgagatt acttggaaga 2100 aggaatgaag gcctcctgtg agcttgccct atgcaaaact gaggacatag ggagatgaag 2160 aaatagagct ggtccctaag gtgtttgaag cctactggcc ctttctgttg tggtttctaa 2220 aacggggatt tgagaggctt tgttgactgt aaagttaccc agcactgagt tacccacatt 2280 tagtgtgggt aactaaatga gagtctccac tcagcaccgc tcttctctac ttattactgg 2340 aagagaggtc ctgatgtggg gtggttaaga tgtttcctgc aaaggtagtt ggcccaatcc 2400 agaagaccta cattatttta gagtcattgg tgttacaaag gtaggtcgaa actttgtaat 2460 cccgcccctg ccctccaata gctttctttt agcagaaaag tggtccagca ctgttcaatg 2520 actttgaaag ccttttactt ctatctgcaa tatttgtttt tagataaatc accaaaaaca 2580 tctgagattc cagttggttc acatgactat gtggagttgt aacttaacaa aattaaatca 2640 tattattcat gtacaaaccc atactaactt tataaataag gacaccatgt atacatgccc 2700 acagcaggga acattgttat aagctcactc ctactgatga tctcagtgat gcatggatga 2760 gtgttaacat tgaaaggcca ccacaatcat tagtcaggac attgatcaat gtcacattga 2820 tagcagagat agcctcagac ctttactggc tcttcctagt gatgatggtg aaggtgttag 2880 cacctttcat ttgttcaggg ctctgaagtc ttcctgaact ctaatttcat ttgaacctct 2940 tgtggctcct ataggatgga gagggacaga tacagaaaaa gattcagggg gttgtctaag 3000 gtcacaggct tggttaagcg gtaccattag gagtagtagg tatgtttttt ggctctttct 3060 acttgtccac ctttggactt gtagtgtgtg ctcaattaca aatgcctctc aacttatgat 3120 gaggctgtgt cccaataaac ccaatcgtaa gttgaaaata ctgaaagtag aagatgcatt 3180 taatacactt aacctactaa acattataga ttagcctaac ctaccttaaa catggtcgaa 3240 acactcacat tagcctactg ttggacaaaa tcatctgaca caaagcccat ttgataataa 3300 agtgttgaat agctcatgta atttattgaa tactgtatta aaagtgaaaa atgaaatggt 3360 tgtatgggta cttgaagtac agtttttatt gaatgcctaa tgcttttgca ccatcgtaaa 3420 gttgaaaaat cattaagttg cagaccatct gtgcttaaaa gcaaataaat aggtcattta 3480 acaaacattt taaaagtgaa atcatgagtt aattttcttt tatcacttgg taattgtctg 3540 aactaagtgg ctaactgctc aggacatagc agatgcacca tcaagctggg cacttcaagc 3600 tgtcttctag aaatgaattt ctgtgctttt tagcactgct ttttgcttgg gggtgggaaa 3660 gggtggtctc cagtaactgc taagatgaca cctatactgg ctgctgtccg agcagcccta 3720 gtgactgtct tgggggcaat cagttgctta atggttaata cagaagtacc tgagtaatac 3780 tttgcaaaag gactttcccc gacctgtgct gggagtgtct ccctgtaaac tttgccaacc 3840 tcctggttgt tttatcagtg agagcatcat ttaagtgaaa atataaatta aggagacagg 3900 gctcatagga cgcacattaa aacacctgat cattttgagc acctgctgtg tgcaaggcac 3960 tgttctaggc caacagtata gatatacatt gcctcccatc ttttaaggct gataatgaag 4020 agaagaacat ggaagaggaa gttgttgggt tttttttttc cagtcagaaa tactgaaaga 4080 tttcttacag ctgtctggtt tcctgatact taaattgtga aactttaagt tcactccatt 4140 atcatttcta aaatttattt tgaataagtt ccctttcggg ggagataccc atgtgtagag 4200 aatggtatgg aaatctgcca atggagggat tagaaatttt gtcagtttaa agacttggac 4260 cttttgagat ttttgttgtt gttgttttgt ttgttcttct tttctgagat gaaggctcac 4320 tctgtcgccc agcctggagt gcagtggtgc aatctcagct cacggcaatc tccgcctcct 4380 gggttcaagc aatcctccct gcctcagcct tctgagtagt tgggattact tacaagcatg 4440 tgccaccaca cccagctaat ttttgtattt cctgtagaaa tggggtttca tcatgttggc 4500 caggctggtc ttgaactcct gaccccaagt gatctgcccg tctcgtcctc acaaaatgct 4560 gggattacag gtgtgagcca ctgcgcctgg cctttctggg gtatatttgg cttaagttag 4620 ttggaagggc tctctttatt ttttattctg cctcccactg aagagacaga gttcgctctt 4680 gtcacccagg ctggagtgct ttggcgtgat cccagttcac tgcacctcca tctcctggat 4740 tcaagtgatt ctcctgcctc agcctcccta gtagctgtga ttacaggcgc ccgccaccat 4800 gcctggctaa tttttgtatt tttagtagag atgggtttca ccatgttggc cagggtggtc 4860 ttgaactcct gaccttaggt gagcccgcct cggcctccca aaatgctggg attacaggtg 4920 tgagccaccg tgcctggccc tgtcttgtaa tttagaagag caagtttaaa tacttgggat 4980 gatgtattaa aaagcctcat ccatgctgac aagagcaggg cctgtagtag cctttgttgt 5040 ttatcccctt catcctgttc tgtacttcat tttctctcat tactgaatta gctggcagca 5100 ttccttattt gccacagagc tatttcttaa aagctgtact tacactcagg atacagtttt 5160 ccttggtata gaactcttcc atggcattgc tctttcactg agctttatta accctcaggc 5220 ttccagtacc ccttcttctg ctctccccac ttcattccct atcatcttac aaaggcttct 5280 tcaaccagga attggcatga gctgaccgtg tatgggaaga gattgtcagt taacctcatt 5340 attgtaaatg ctcagtgttc agaatgctgc tacttaaatg acatcctata gaactgcatg 5400 aatcgggata catttaaata atccagttaa gtggctgttt cttgatggtt gaggctctgc 5460 ttttgggttg tagaacactg ggaagaagtc ttcacagctc agatagtttt ttagttggtc 5520 tcatttcctt tctacagtcc atgcttcagg caaagttaca tattgcctgc ctgcccacac 5580 ctttctgtga gcatctgaaa tcttgctcac tcctctttat tgacaccaga ccatactggt 5640 tggaagcttc tttccagtcc ccgctttcct ccctccattg gtaaaacatc tggtggggag 5700 gtcttcgtgt ggtctttggg cctacccttg ggcgctggta cagtgagact ggagagatgg 5760 gtgtgtattc attctgcctc ccactgaagc aatgacgtct tcttggtgtt tgggtctctg 5820 ggtgccccca ctcttcctgt aaatgttaac ccccacggag gtgaggggaa tggagaagct 5880 tatctcagag aggctctctg gagagggagg accacttctg ctttccaggg ggaagctgtg 5940 tcacggagag cagaactgta gcccgatgct ggagagaaaa ggccccagag gaggcaggca 6000 aggaagtgat acttcctcca ccccaggccc ctgggtcatt tgcctgcagc cccaccttcc 6060 ttaccaccca atgctgcgtt ttcctcgggg ttctttctac cctctgctgc cctctgcatt 6120 ttcggtttgc ccttaagtga ggggtggggc ggggtgggag agaggagcag tctagagtct 6180 taagggcaga gcctgctttg cgaagcccac cctggccatg cctgactttt tcagcaacgg 6240 aaaaatgtac attttgaaat tccccgtcat ggaaagtgtt atgaaactct tgggtagacg 6300 tttcgaaatc ttttaatgtt caggctacat aataattttt aaatactaac tataataatt 6360 caggactatt ttaaaaattg ttaaattcct tgttaaattc ttgggataga acagtggctg 6420 tcaaacatct tttttttttt ttttttgaga tggagtctcg ctctgtcgcc caggctgtag 6480 tacaatggtg caatctccac tcactgcaac ccctcctccc aggttcaagc gattctgctg 6540 cctcagcctc ccgagtagct gggattacag gcatgcacca atgcaccacc atgcccggct 6600 aatttttgta tttttagtag agacagggtt tcatcatgtt ggccagcctg gtctcgaaca 6660 cctgacctca ggtgatctgc ctgcctcggc ctcccaaagt gctgggatta caggcatgag 6720 ccacgcgccc agcctgtcaa acttatttga ccacaaccca tagcaagaaa cattttacct 6780 tgtgctcaaa tacacatatc tgtaggcaaa acaaaataga aaaaggaaaa tacaatctgg 6840 tggaacagcc cctcccctta acttgcaggg gaatgtggcc tggagcagct tttctgaggt 6900 aggattggcc agctccatca gagtttgttt gttctgatgc ataatagata tacatagttt 6960 cagggcacat gtgataattt aatacatcat ataatttgta aagattaaat cagtatttgc 7020 gatagccatc accttaaata tttgttttct ttttaaatgc tgaatctttt gaattcttct 7080 agctgttttg aaatgcacaa tagttaatgg tgaactctag tcaccctacc aggtcttatt 7140 tcttctatca aacagtatat ttgtatccat taatcaacat attttcatcc ccccttccaa 7200 cgtacagaga tgggcagtcc aatagggagg tttattaaac aaacacaaat taagtcacat 7260 tcatataatg ggatactttg taaatatctt aaaagataaa acattcaatt acagttacta 7320 atatgaaaaa ttttttttca aaagctgaac acggccaggc ggccaggcgc agtggccctt 7380 gcctgtaatc ccagcactct gggagcatga ggcaggagga ttgcttgagc tcaggagctc 7440 gaaatcagcc tgtgcaattt gtctcaaaca aacaaacaat agcaaaagag ctgaacacaa 7500 actagtagat gacatgatac catttctgaa ataaaatatt catatatgga cacatcatct 7560 ataaactgca tttcaaacaa tttttatact aagatcttaa tagtgattat ttctgggtga 7620 cagttgagtg ctgtttttac ttctgtacgt ctttatattt aaaagaatga gcatcccata 7680 tatacataaa tatatatata aatcccacat ataaatatat acataaatcc catataaaaa 7740 tataaatata tatatatata tatacacaca cacacacaca cacacacaca catatatata 7800 tatttttttt ttcctgagac agagtcttgc tctgtcaccc aggctggact gtgatggtgt 7860 gatctcggct cactgcaacc tccacctccc gggttcaagt gattcctgtg cttcagcctc 7920 ctgagtagct ggaattacag gcacacacca ccatgcccag ctactttttg tatttttagt 7980 acagacaggg ctttgctgtg ttggccaggc tggtctcgaa cttctggcct caagttatcc 8040 ggctgcctca gcctcccgaa atccggggat tacaggcata agtcattgcg cctggctcct 8100 tatatgattt taaaacggca ggatataagg agcaatggaa tgaagccagt gggactgcag 8160 aaggcaggtg gaagcagaca gggaactttg gagctagagt gacttgaagg acgcttgatg 8220 gatataattg taagagtcct gtctcaggag agctgatgcg ctgtaaatgt tgtaaataga 8280 acattttctt aaagaacctt ccactgctat gtttagtatt cagtttagca aacttttcct 8340 gggtagctac tgggagtccc gcacagtgtt aggagttggg gtacacacct gccatgttgg 8400 tggaaatcct gaagggagtg ggccacacac cctggaagaa ggggctttcc tgaggaagga 8460 cagcctgact atgcaggggt cattccacat taccagagct tgttccagag aggcagtggg 8520 aggctccaca ggcaggcttg gagggtgctt ggccctaata ctaaatgttg gacttcatgg 8580 cattaacgaa ggggaatcac tggagccttt tagtatgaag ctaatctttt tgtccatcac 8640 aggcaacttc ttgcctacac tcttttacaa tatggcattt atgacatagc caagagcgaa 8700 gacacgttga acactgactt aatgctttga gtaggtggag agttgaatga ctcaaggcta 8760 cttctctaga gattaatttg aagctagaaa gtaacattta tttctgtttt ctgtgacagc 8820 aataggcttc agcttgtaat cgtcatctgc aagtaggtac ttgacacctc ccctaagtga 8880 cctggagagt gacagataca gtaatgggca caatccttgg ttttttgttt tgttttgttt 8940 ttgagacaga gtctcactct gtcatccagg ctggagtgca gtggtacgat ctcactcacc 9000 agggatttgg ccaccacgcc tggccgaatc cctggtttta agcaaaattt taatatggag 9060 tttatggttg ttggtataat gaaatgcggc accatagcag ttgatttttg tctttcagaa 9120 ccacactggc tttttgtatt atttcaaatt tgatagatgc ccaatgtatg taacaaaaat 9180 tttccctcac gtgtatttct ttctttattt atttgtatgt tttgagatgg ggtctcactc 9240 tgtcgcccag gctgaagtgc agtggtgcta tctcggctca ctgcaacctc cacctcccag 9300 gcccaagcca tcctctcacc tcagtactgg gtagctagga ttacaggccc cgccaccagg 9360 cctgcgtaat ttttttgttt tttgggaggc caaggcagga ggataatttg agctcaggag 9420 tttgagacca ggctgtaacc ccaggcagga gtacagtggt gcagtcatag ctcactgcac 9480 ccttgacctc ctgggctcaa gccatcttcc cacttcagcc tccaagtagc tgggactaca 9540 ggtgtgtgcc actatgcctg gcttattttt tgtagagatg gggtttggcc atgttggcca 9600 gcctggtgtc aaactcctaa gctcaaggga tccacctgcc tcagcctccc aaagtgctgt 9660 gctgggatta caggcgtgag ccaccacacc cagcccaagt atatttatcg agtgctgtat 9720 gtcatgatag tgggtggttt gggggaatac caacataaat aagtgggagg tttctatcct 9780 agaggagttt attgtgctct gttctctctg gattgttcac aaaccagaat gccgatcaaa 9840 gactttgcta gggttgtggg tgggcgactt gctcaggaga tccctggcac ccaaatgagt 9900 gcccagaaat cactctgaat ggtcaaaagt aaggcagggc agggcggtag agcacagggt 9960 gtcgaattaa tttcatgtgg gggctgaaat cccaggtctg tcccttccta actgtgggct 10020 gctgctggca aggtgctggc cttgctagcc tcagagtcct catgtttaaa cctcagcagt 10080 ttgttgtgag tgttctaggt tacagtggat tccaaactag ccacaagtga agcacatggc 10140 taaatggtag tcattggtat tgttatcaaa agcaagttgc ttagctgggt gaagtggctc 10200 atgcctataa tcccagcact ttgggagcct gagacaggtg gattgcttga agccaggagt 10260 tcaaggccag cctgggcaat aaagtgagaa cctgcctcta tagacaaaaa aaaaaaaaaa 10320 aaaaaagaat aaataaaaac aaataaaaat tactcagagt gcagtgatgt aatcctatag 10380 tctcaactac tcaggagact gaggcaggag gattgcttga gcccaggaga ttgaggctgc 10440 agtgagcaat gattacacca ccacactcca tcctgggtga cagagcgaca gcctgtctgt 10500 aaaataataa taacaataat aaaaagaaag ttgcttagga tggctactat aaaaaatgag 10560 aaatcatgat gaaatcatgt catgttaaaa aagaacacaa caacaaaaat cagaaaataa 10620 taagtggtgc caaggatgtg gagaaattgg aatcctgtgc tttgttggtg ggagtgtaaa 10680 atgctacagc tatgatggaa aatcatatgg tagttcctca aaaaattaga catagaattg 10740 ccatatgatg cagcaatgct gcttctgggt atatacccca aataactgaa tgtggggtct 10800 cagagatgtt tgtacacttg tgttcatagt agcattattc acaatagcca agaattagaa 10860 gtaactcatg ttcatcaatg gatgaaataa aatgtggttt atatgtacat tggaattttt 10920 tttttttttt tttgaaacag ggttttactc tgtcacccgg gctagagtgt ggtggcacca 10980 ttacagctca ctatagactt gacttcctgg gctcaggtga tcctcccacc tcagcctctt 11040 gagtagctga gactacaggt gcatgccacc atgcctggct agttttttgt attttttgta 11100 gagataaggt tttgccatgt tgtccaggct aatcttgaac tcctgggctc aagcaatcta 11160 cctgctgtgg cctcccaaag tgctgggatt gcaggcatga accaccgtgc ccagccatac 11220 aatggaatgt tattcagcct ttaaaaaaag gaaatgctgg ctgggtgcgg tggctcatgc 11280 ctgtaatccc agcactttgg gaggccaagg tgggcggatc acctgaggtc ggcagtttga 11340 caccagcctg accaacatgg agaaacccca tctctactaa aaatacaaaa ttagtcgaac 11400 atggtggtgc atgcctgtaa tcctggctac ttgggaggct gaggcagaag aatcacttga 11460 acccgggagg cagaggttgc agtgagtcga gatcccgcga ctgcactcca gccagggcaa 11520 caagagcgaa actccggctc aaaaaaaaaa aaaaggaaat gctgacacat gatacaacaa 11580 ggacaaaact tgaggacatc atgctaagtg aaataagcca gacacaaaaa gacaaatact 11640 gtatgagtcc actaatgtga ggttcctcaa atagtcaaat tcatagagac agaaaataga 11700 atggtgtctt ccaggggctt gatgggggag ggaatgggaa gttactgctt aatgggtaca 11760 gagtttcagt tttgcaagat gaaaagagtt ctggagatgg atggtgtgat ggttatacaa 11820 gaatatgaat gtacttaatg ccactgagtt atatacttaa aatagttacg atacaagttt 11880 tatattgtgt ttattttacc acaactttaa agaatgaaaa aaaagttgct tgatgagcag 11940 atacgtgtac aaatagacag aggtgtcctt gaggatattt cattaagttt gataaattgc 12000 ccttcttctg gctgggtatt tacctaccaa gcagacgggt gttcactttt ttggcagaga 12060 gaggacagga tctttactct tcgtcattta atacatggcc acgtggattg ctggctgaca 12120 gtatattgaa atggctgtga tgtgggagag ggaatgataa tggagaaatt tacaaaggca 12180 gagattgtgg attacaaagt aaggagaaac ttctaaccat caaagctgcc tgcatgggtc 12240 ctggagaagg gtccttctcc atcattaaat gtttgtcagc aaaggctaag agattcttac 12300 aagacctttt agaaaaggtt gcattaaggc cagggcgcag tggcgcacac ctgtaatccc 12360 agcattttag aaggccgagg cagatggatc acgaggtcag gagttcaaga ccagcctggt 12420 caacaaagtg aaaccccatc tcttctaaaa atccaaaaat agccaggtgt ggtggcacac 12480 acctgtagtc ccagctactt gggaggctga ggcaggagaa tcacttgaac ctaggaggtg 12540 gagtttgcat tgagctgaga ccacgccgtt ggactcctgc ctgggcgaca gagcaagact 12600 ccatctcaaa aaaataaata cataaaaaag ttgcattaga tggctgtaaa aggtgcttcc 12660 tgatttgatg atacagttat attaatattt ctagccatgc actcattaac tccaaattac 12720 ataataagaa agtatctttc ttttttttga ggcagggtct tgctctgtca cccaagatgg 12780 agtgcagtga taccatcata gttcattgca gccttgaact cctgggctca aatgatcctc 12840 ccatctcgag atcccaaagt cctgggatta cgagcatgag ccattgtgcc ttgccaaaga 12900 aagaatattt ctgacacagt tctttctaac aggattcgag ggaatttttt aaaaagtttt 12960 cccaatgcag gagtgtgtgt gtatgtgtgt gtatgtgtgt ttaaaattta agtataacac 13020 ttacatagaa aagtgcagaa aacagaagaa tctagctgaa tgcaaagcct tgtgtaacca 13080 cccccatgat caaaaagcag aatgatgttg accctccccc aagcagtact cccctgaaag 13140 gcatctgcca ttctacttct agtttttgtt tagtttccag tgtaggcttc taaacaataa 13200 agtgtaggga attgaaaagc agtacaaagc catttggttt ggcaaataaa cagattttca 13260 agctgtgggt ttggctacca ccggcatctc tctgtgtgtg gaatttactt gcaattcaac 13320 tggagagcaa gacctcgtcc tgttttaccc tggcgattca gttgctaaaa ttctcacaca 13380 tgagtttgat ctgagcctta tttaaatacc tttttattca tccattaatt agtaaaatta 13440 gctggcataa gctatatata gctggttttt ctgcacagcc aagtcaattt ataaatgcaa 13500 atatgtgggt gtgataaggg tggtttccac tgacccacat gtaatcaaac atcctgttat 13560 atgacacagt gccagtctgt gcataggcat ttgaaagtac taactgggtt tgtgaattca 13620 gtgatgctgt tcttcaataa aataaagact catttttctg atgttaagga acacagcacc 13680 tttgttactg actgttattt caacttctgt ttcatgtagt tttgatattt atttttgttg 13740 ggggtgacag agagaggcat aattgacctg tggcatttgt taatccatga agtcatgctt 13800 cacttatgca tcattcagaa aacacttctt ggatactcac tactcatgaa tatgcatgca 13860 tatgacttgc agtcaaagcc atgagttctc aatagcaaaa ctgttccaga tatactcaga 13920 gagttaaaat gtttaaaaaa ctttttttta aagaaaattt tccttttatt tttgttgttt 13980 tgttttgttt ttttttagaa gcaagatctc actatgttgc ccaggctaga gtgcactggc 14040 cattcacagg cacgattatc actcacacac tatggtcctg agatcctggg ctgaagtgat 14100 cctcctgcct cagcttctcg agtagctggg actagaggca tgtgccactg cacctggctt 14160 agagtataaa tttttgtgtc acacaagata tgaagaacat gcacaggcac tggacccatc 14220 tgtgggttca tctttctgtg ggacccacta agggacccat ctttctgtga aaaagtcaca 14280 agtgaagtcc tggccatgca aggaataacc ataccccaag agatcatgct gagcctgtag 14340 tttgcctgtc tgcatccccc aaccccccca gcttattttt attttatttt ttacttttta 14400 ttattttaga cagggtcttg ttctgttgct gaggctggag tgcagtggca tggtcatggc 14460 tcctgcagcc tccacctcct gggcttaagt gatcctccct cctcagcctc ctgagtagct 14520 gggactagag gtgcatgcca ctgtgccaga ttaactttct taattttttt ttttttgaga 14580 cagtggtcac tctgtcaccc aaacttaagt gcagtggctc aatcttggct cactgcagcc 14640 tcaacctcct gggctccagg gatcctccca ccttagcctc ccaagtagct gagactacag 14700 gcatgtgcca ctacacctgg ctaatttttt tttttttttt gacggagtct tgttctgttg 14760 cccaggctgg agttcattgg cgctatcttg gctcactgca acctctgcct cgtgggttca 14820 agctattctc cttcttcagc ctcctgtgta gctattatta caggcacctg ccaccatacc 14880 cagctaattt ttttgtattt ttagtagaga cggggttttg ccgtgttggc caggctggtc 14940 tcaaactcct gatctcaggt gatccacccg cctcagcctc ccaaagttct gggattacag 15000 gcgtgagcca ccatgcctgg cctgcctggc taatttttgt attttttgta gagatggggt 15060 tttgccatgt tgcccaggct ggtttcaatc tcctgtgctc aagtgatcca tccatgtgct 15120 tcagcctccc aaagtgctgg gattacaggt gtgagccaca gtgccaagcc taaaattttt 15180 tgtatagttg gggatctcac tatgttgccc aggctggtct tgaactcctg gtctcaagcg 15240 atcttcccac ctgcttcagc ctcccaaagt gctgggatta cagacgtgaa ccactgcagc 15300 cagccccaaa acctccagtt tatttcctcc agccacagtt cctgatgctt ggcatctctg 15360 cgttttaact gcttgtctct gttagcaact gctggatgct acagaggatt tgaacaaaga 15420 gtgaatcctg agaatggagg gaatattgga ctaaggagac tgaccagagc agaacagttt 15480 ccaagtgaag aagtgagtcc cttagttgga aataaagtag gaagagatgg ggaaataact 15540 tggctggatt ccttactaat cttggtgaat aatataggta tggattagta acactgtagt 15600 agctaatgaa aaatattcca ggttgtgaac tttggggtgt ctgaggagca gcatgatgtc 15660 gtagtcataa actgagagtc atgaattggt ttctgggctg ggtgtggtgg ctcacacctg 15720 tagtcacagc acttggggag gccaaggcag gaggatcact tgaggccagg aattcaagac 15780 caggctgggc atcatagtga gacctcatct ctacaatttt ttttttaaag gaattggctt 15840 ctagtcaatg ctttgtcaaa taccagtctt gggacattag atgaagctcc ttcatctaat 15900 gtttttctaa tacataaaac agtaataaca gatttttgtt tggtatctca tccagttgtt 15960 gcaaggatta aacggggtaa tgtacctggg agttccttga agagtctaat tttctaccca 16020 gttttggctg ttgttttgga ttaaactgta ctaccccgag ccttttcttg attttggagg 16080 atccctaccc actccctact catggtaccc ctggcctgtt ctggtagatt cactcatgca 16140 tcatcaccag tcctgtgggg aagtggaaat ttggtgtaca taccaggtgc actttcattc 16200 ttctcaaaat gttatgacaa atagcaaaga gaacaccttt tcttttatca ttagctcatc 16260 cttaagcatc tcgttagggg taaagcaatt aaaaaaaaaa aacaagtttt agctagacgt 16320 ggtggcatgc ccctgtcatc ctagctgctc tggaggctga agtgagtggg tcccttgagt 16380 ccaggagttg gaggctgcag tgagctatga ttatgccact gcactccagc ctgggtagca 16440 gagcaagact ctcatctctg aaaaaaaaag aaaagaaaaa gaaacaacaa catcaaacaa 16500 agaaacaaaa gcaagtttat aaataaagaa acagaatagc agggacatgg atgcagctgg 16560 aaaccatcat tctcagcaaa ctaacataag aacagaaaac caaacacggc atgttcttac 16620 tcataagtgg gagctgaaca atgagaacac atggacacag ggaggggaac atcacacacc 16680 ggggcctgtc ggggggtggg gggcctaagg gagagatggc attaggagaa atacctaatg 16740 tagatgacgg gatggtgggt acagcaaacc accatggctc atgtatacct atgtaacaaa 16800 cctgcatgtt cggcacatgt atcttagaaa ttagagtata ataaaaaaat tttaaaaaaa 16860 agaaacatag aataaaaacc atacctaatt tagtaagaga ggcattcccc ccaagctcct 16920 cacgtttatt tatttattta tttagagaca gagcctcgct ctgttaacca ggttggagtg 16980 cagtggcgtg atctcggctc cccgcaacct ctgccttccg ggttcaagca attctcccta 17040 cctcagcctc ctgagttgct gggactacag gtgcccgcca tcacccccag ctaatttttg 17100 tatttttagt agagacgggg ttttgccatg ttggccaggt taatctcaaa ctcctgacct 17160 taggtgatcc gcctgccttg gcctcccaaa gtgctggaat tacaggcatg agccactgca 17220 cccggcctaa acttcattta aatgatgagg aaataactgc aatggaatga gctggttgga 17280 gaacgatgtt actcacccga acgctggctt tatgcagttt caacatccac aggtatcttc 17340 tgattgatcg cattacagtc ttgacctaat ttctcctgat aaggagctga aaatcaagca 17400 acagtacatt agaactttga ttcatgtgac gcctatcatg ccatataaat gaaaattcag 17460 agtttagatt aagaacagta aagctttctc tgttgtacct taaaaggtac ttccctcctc 17520 ctcataataa taagctacat gcttctggaa gttttaccaa gacttgagat caggagggag 17580 cattctgacg ctgagcacac ctctgacttt gcacatggtg gtttcgaggg gttgacagca 17640 gaagatctcc agagtctagt aacagttctg tcttactgtt caaatttgcc ttttctacct 17700 caatttctcc tccattttaa cagaaaacct actactacta cttcatatgt atctaaaata 17760 tttcaaaatc tttagtaatg ggatataagc actcttagcc atcagaataa cttttaaggt 17820 caggtgcagt tgctcacacc tgtaatgcta gcactttggg aggccgaggc aggaagatca 17880 cttgagcgca gaagtttgag accatcctag gcaacatagt gagacctcat ctctatagga 17940 aattaaaaaa attagccaag agtggtggca tgggcctgta ttcccagcta ctcaggaggc 18000 tgagttggga ggattgcttg agcctgagag gtggaggctg cagtgagtcg agatcgcgcc 18060 actgtactcc agcctgcgtg acagtgaggc cctgtctcac aaacaacaac aacaacaaca 18120 aaaactttta aagattagta agcaattttt ttctttggaa aaaattaaaa tgaaaataga 18180 cgattttaag aaaacttttt atgtttttta aatcaacttt aaaattttgc tatatagctc 18240 tatgaatttt aatacatgtg cagattcact gaattatttt cataatgaga atacagaaaa 18300 gttctgtgac accctccccc caaaaaaaaa ctttcttgtg ccacccccag cccaatgcct 18360 ggcaactgct gacctgttgt ctgtccccat tgttttgtgt tttctgtaat gtcatataaa 18420 tagattcata ctgtatgtga tcgttttatt gtcttttata ataacagctt tatttttact 18480 tttaattttg ttttgagaca gagtctccct ctgtcaccca ggctggagtg cagtggcaca 18540 ctcttggctc actgcaacct ccgccttccg tgttcaagca atcctcccat ctcagcctcc 18600 caagtagctg agaccacagg cacgtgcaac catgcctggc taatttttgt atttttggta 18660 gagacaaagt ctcaccatgt tgcccaggct ggtcttgaac tcctggactc aagtgattca 18720 cctgccttgg cctcccatag tgttgagatt acaggtgtga gccacccaca cccagctgaa 18780 taatagtttt attgagatat aattcacata ttgtataatt cactcaaagt atacaattca 18840 gtgattttta gtatgttcac agagttgtgc aatcatcacc acaatcaatt ttagaacatt 18900 tttattacac aaaaagaaat tctgtatcct ttagccctca ctactctctt ccccttgtcc 18960 taggcagtca ctaatctatt tctagctcta taataaattt taggaaactg gttttaatga 19020 tttccttttt ttaaatagac agtttcttgc tctgatgcct ggagtgcagt ggcacaatca 19080 cgatcactgt agcctctgat cttctgggct cacgcaatcc tcctgcctca gcctcctgtg 19140 tagctgggac cacaggtgta caccactgtg ctgggctaat tttttttatt ttttgtaagg 19200 atgaggtctc catatattgc ccaaagtgtt gggattacag gcatgagaca ctgtacccag 19260 ctaagtttct ttcttagttg gaagagtttt acaatgatgc cagcacagtt actacctgtt 19320 ttacttttgt atcaggcaat aattaccttt cacagaaaat atagtaagaa tagcaatcct 19380 ttattaaata tttgtcctct gttaggtagt caattcctta aaaggtgtaa tattgatatt 19440 cttgttattg ataaggaaac agatgcttgg ggataataaa tattatgctc acttaactac 19500 taagtaaatg gaacccaagt cagccggacc cctaaactga tgtgtttgtt ttatttaact 19560 ttgaaaggtt attttttaaa aaatcacagt tgtaatatgt ggaacataat gtccttgact 19620 ttagtttatc aagcagactt tatacattaa cataaatgta aacgcaggaa taagaccact 19680 tctgggaaat gtataataaa tataatgcag agaacattta ttgagtgcac acggtatgtc 19740 attcgttctt ctaaacactc gtcaagattg tattcaacca atccttataa caagtgtgtg 19800 aagttggtac agttatcatc ccttttcttt tcttttcttt tttcttttct tttttgagat 19860 ggggtcttac acagttaccc aggctggagt gcaatggcac gatctcagtt cactgcaacc 19920 tctgcctcct gggttcaagt gattctcctg tctcagcttc ccaagtagct gggattgcag 19980 gcacacgcca ccatgcccag ataatttttt gtattttagt agagatgggg tttcaccgtg 20040 ttgcctaggc tggtctgagc tcaggcaatc cacccgcctc ggcctcccaa agtgctagga 20100 ttacaggcat gagccaccgt gcccagcctt atcatccctt ttctgcagat aagtaaagat 20160 gaattacctt gccaatgtca tgtcactgta cgaggtggag ctgaacttgg gcctaggatg 20220 tttagctcaa gcttaactac tgctccagga atctaatgcg ctgccactcg aacttcagga 20280 agacaagagc tcagacactg aaaaccagtc agcaaggcca aaacaagaga gcccccagtt 20340 ctgccaactt ggtgcaattt ttactataac catagctggg aaaaatgaag aagaaaaaaa 20400 ttcactggag ttgcaatgaa tatttaaaca ttgcgtcaag tttaaagcat gatgagtgtc 20460 aagccagttg agttttctgc attaacttca gctgacaact cagtttatat ctattataaa 20520 tgtcactatt tgttggggga aaaataatct tcctcttttt tatttttaat tttttttagg 20580 gataggattt cattgtgttg cccaggctga agtacagtga tgtgatcatt gctctctgca 20640 gccttgaact ccttggctca agtggtcctc ctgcctcagc ttcctgagta gctgagactt 20700 cagagtcaca tcaccatgcc cagctaattt tttttttttt ttttttttgg tggagatagg 20760 accttactat ggtgcccagg ctagtctcaa actcgtggcc tcaaatggtc ctccagtctt 20820 ggcctcccaa agtattggga ttataagtgt gagccattgt gcccagttta attttcttct 20880 tttgccaaag caaagctaat aattttttta tagctaagat ttaattatgt ttggattaaa 20940 ccttctcttc agtatgtatc tcatactttt cttttgctaa atacttatct agcttgcatt 21000 tttttccaca ttaaggagaa tagctcttgg aaatcttata ttctcctaac tctttatctt 21060 aaaatgctgc cacaaaatct tagacattga aaagttatta aggttctagt tgagagttta 21120 ctaacaacaa aaagaaggat aattggcaaa gaagacgtgg attgagtgag ccacatagcc 21180 cctttcctgt tctggtttct tggtggcatt tgcagcagtg cctctatgat gcctgagcaa 21240 aactggttta ttgggaagtg atgtaaacca tactgccagt gcttttgctc agcacttggg 21300 cacttcgtgg ccgtgtgtct catatgatgt tcataatgct tttttttccc tctccttccc 21360 cccgtaatac tttatgaata gatgtttcca cttctgaata gttctccgat tagaatagca 21420 gttacaaaat gggtaagact tcacctcgtc ctttaaaaca ggaaaattga tagaattcct 21480 ccacctcctt tcattactga ggctgtcaga tgattcttta agcaaaaccc cagtgttctc 21540 ttgtctgatg aagtcagtgt aagtgatggt atttttacat tgactttaat atgaaaggaa 21600 ctgtttaatt gaacggtttc atctcaaggc caggctttag actccttctt gggctcatgc 21660 atgggatcct tcttttgcac acctgtggcc tccctggaac tacttctggt ggtttccctg 21720 gacttagtat cccccaaacc tggcagccca gggcctagtg acaggcagag gaatgtattg 21780 ctcttgctct gtggggtcag gtagggccgg gggaggtcct gcatgaatat tttcagtgct 21840 gattcagaaa gagcattggg catacacttc aggaaaccct acctggaagc tacagcagca 21900 ctgctctatc ctagactgac cacttcagat atttccaacg cggagctgga tgtggctagg 21960 aaccggctcc cagctgaata gcttgtgctg agtcattatc aagttgcatt tcctggctca 22020 accaaagata agcagggaag aacctaaatg aaaaatgact ttcagactgt gatttgggtt 22080 agtataccac ctcagggcag caatggagtc atgactgcac agacacggga aaggatctgg 22140 ttgcagaaac caagtgagtc agtgatgatg tatcatcatt ctaaaaaacg tacctgtact 22200 ttcttttttt tttgagacga gtttcactct tattgcccag actggactgc aatggtgcga 22260 tcttggctta ccacaacctc tgtctcctgg gttcaagcaa ttctcccacc tcagcctccc 22320 gagtagctgg gattgcaggc atgtgccacc actgcttggc taattttgta tttttagtag 22380 agacagggtt tctacatgtt ggtcaggctg gtctcgaact cccaacctca ggtgatctgc 22440 ccatttttgc ctcccaaagt gctgggatga taggcgtgag ccattgcgcc tggccgtaac 22500 agtgtacttt ctttctttct tttttttttt tttgagatgg aatttcgctc tgtagcccag 22560 attggagtgc agtggcgtga attcagctca ctgcaacttc cgcctcccag gttcaagcaa 22620 ttctcctgcc tcagcctcct gagtagctgg aattacaggt gcgctccaca acgcccagct 22680 aatttttttt ttctagaagt tgaattgtac aaagtacact tatattttga cacctgatcc 22740 aaaacacagt catgtaccac attacaatgt ttcaatcaat atatagcata caaaaaaaaa 22800 acaacaacaa cagtagtcct atgagataag agctgaaaat tccttattac ttaaatgtta 22860 ttttgaaagt caacattttt cttctacata ttttactcat aagcatggca aaatgttaca 22920 ggtctcattg tcaccactgc aatatgcata ctgtgatgga agcataacct atctcaattt 22980 agccacatta actatttttg gacaccttga tcaacagtgc ccattctcat ctagcatgag 23040 gctttttttt tttggagacg gagtctctct ttgttgccca ggctggagtg cagcggcgca 23100 atctccactc actgcaacct ccgcctcttg ggttccagcg attctcctgc ctcagcctcc 23160 cgagtagctg ggactacagg tgtgtgccac cacacccagc taattttgta ttttttagta 23220 cagacagggt ttcaccatat cggccaggct ggtctcgaac tcctgacttc gcgatccgcc 23280 cacttcagcc tcccacagtg ctgggattac atgcgtgagc cactgcgccc ggcctacgcc 23340 cagctaattt ttatatattt ggtagagacg ggatttcacc atgttggcca ggctggtctc 23400 gaactcctca cctcaagtga ttcgcccacc tcagcctccc aaagtgctgg gattacaggc 23460 gtgagccacc gtgctgggcc ttgtactttc ttgaatggga agttgtcttc atggtgagca 23520 gctcttcttt gaggtgttta tttgaagtat tcaaaagaac agagagattc cagtagggaa 23580 caatgaaaat attaaggctt ctatatcatg ccctgtgagg gaaagtagac aaagatgaaa 23640 taaacttcaa caagagacta aaaaactact tgagtgtttt tgattaccaa cttttcatga 23700 gctgaatagt ttgaaaattt gctgcttttc taagttttcc ctttaagatc agggataaat 23760 catttcctgg aaggatattt ttcactgtaa gctctttctg tttctatgtt gataatctaa 23820 tctgaataat taagttttat tgagaccttc cttttgaaag taacttgtta cctatgtatg 23880 attaacctgg ctattattct aaatgtagaa tttaaagtgt tttatccatg gtagctcaca 23940 cctgtaatcc cagcactatg ggaggccaag gtaggaggat tacttgagcc caggagtttg 24000 acaccagcct gggcaacata gagagaccct atctttacag aaaataaaaa gaaattagtc 24060 aggcatggtg gcatggccct gtagtcccag ctagctactt gggaggctga gatgggagga 24120 tccgcttgag cctcggaggt tgcagctgca ctgggctgtg attgtgccat tacaacagag 24180 taagacagag tctcaaaaaa aaagtgtttt atcatttatg tagagcttgg agtttcaaac 24240 ataaagtaga attactttat cacttgtaaa aaatgtgttc tctgaaagtt gataaacaat 24300 gaggtagaat gactcctgaa attaaaaaaa ataatagcag gactttaata gataaatctg 24360 aaataagtac gatgaacaat tttttaaata aaatataccc tgaagctaat actttgtaaa 24420 taccaacatt ttctttatgg ctatagtgta accaaattca ggagtaagta actcaattat 24480 ttggctgtcg ggttgatgga atgaaaataa atttcttaga atatgatatg aaatatgata 24540 tgaaattcaa ctttactaaa ctttactgaa caccagcaaa tgtatttaca atcctgggtt 24600 ctatttgtca atcacagacc accctttttt ctgagcattt tttctgttct gagttcacat 24660 atggggttag gttggcagtg gataaattcc agtccccacc ctttaatagg gcatggaatt 24720 atgatgccac acaaaataat ttctgtatgt gttaccctgc agatcatgca cctataaaag 24780 ataaagaaat ggccaggtgc ggtggctcat gcctgtaatc ccagctactc gggaggctga 24840 ggcaggagaa ttgcttgagc ccgggaggtg gagtttgcag tgagccgaga ttgcaccact 24900 gctctccagc cttgtaacag agcgagactc catctcaaaa aagaaaaaaa agaagataaa 24960 cataaaaggt ttccattgct atgatttcaa ttctagggtg gagctcaggg tttggcaagg 25020 ttccctacat tattagactg cgcattttac cctttttcaa aagcaggtaa ggttgtagtg 25080 tagagtgtgg ctagtgattc tcaaccctgg ctgctcatta gaatcaatgg ggagcattta 25140 aacctcccca tgcccaagct gttccctaac caatgaaatg ggaatggtgg gggcctaagc 25200 atcagtattt tttagagttc cccaggtgat tctgcttgtg taccaaggat gagaatcatt 25260 ttactagatt cagctatgtg ggaatctttc ggctatttta gaaaacatgg tgacctggct 25320 gggtgtggtg gctcgtgcct gtcatcccag cactttggga ggctgaggca ggcggatcac 25380 ctgaggtcag gagttcaagg ccagcctggc caacatggtg aaaccacatc tctactaaaa 25440 atacaaaaaa ttagccaggc gtggtggcag gcacctgtga ttccagctac tccggaggct 25500 gagcaggaga attacttcaa cccgggaggt ggagattgca gtgagccgat agtgccattg 25560 cactccagcc tgggcaacaa gagtgaaact ccgtctcaaa aaaaaagaaa gaaagaaaga 25620 aagaaagaaa gacaaaagaa aacatggtgg tcagtgaatt aaggtggccc agttaatatc 25680 cagtcagttc ccacctgaat gtcagatgtc ctggagtgct gagatgtgtc cagaattgct 25740 agctacccag ctagaaaagc taccgcaagg tcatctcggg aaaagggaac cacaaatgtc 25800 ccagttaaga ggatggatag tttcccaggg ttggagtcct ttcttttcct agtcaccccc 25860 aaacacttaa gaggcctatg ggatgggcag gggagcaggg agagcctcac tcctctccca 25920 tctgttggga gagcctcact caccaaaaca gcgttgcctt gtctgtgtca tatgcatcat 25980 gtgagtgcat gaagtccctt gctccaggga cttcccatta ggcctggagt gtctcccatg 26040 caaagagccc gctcctctgt tcctgggaca cacctctggc agtcccagag gttgcccatt 26100 catcttgact tctggaaaga agcctatagt gagaaaggag catgtagtca gaaaccacca 26160 agtgcagcat agttctacat aactcacagc attcagtagt tttgtgttgt tgcttttctt 26220 tctttttcca tacagtagtt catctgatat gtgcagttac gcagcacctg ttaagtcaga 26280 gggctgggat ggtgaggtcg ccctgtaaac tctgggcaaa ttactccatt tctgagccat 26340 cttttgccat ctgttagaat ttctgatcag gatttaatcg gggttggttg tgaaagagta 26400 tatgaacatg ctttgataaa gaagaaaata agtgggccag gcacagtggc tcatgcctgt 26460 aataccagta ctttgggagg ctgaggtggg aggattgctt gaggccaaga attcgttttt 26520 tttgttttgt tttgttttgt tttgttttgt ttttgacaga gtttcaatct gtcgcccaga 26580 ctggagtgaa atcacaccca gcaatggcgt gatttcggtt cactgcaact tccacctcct 26640 ggcttcaagt gattcacctt cagcctccca agtagctggg attacatgtg cccaccacca 26700 cgcccagcta atttttgtat ttttagtaga gacagagttt caccatgttg cccaggctag 26760 tcttgaactc ctcacctcag gtaatccacc tgtctcagcc tcccaaagta ctgggattac 26820 aggcgtgagc catcacgcct ggccgaggtc aagaatttga gatcagcttg ggcaacgtag 26880 caagacccag tctctaccaa aaaaaagaaa aagaaaaaaa aaagagagag agaggagaga 26940 gagagagaaa taaatgaaat gtatcccagt tgaacaacag ttgagctgag gtgtaagcct 27000 ccagatgaag gaagaaggag cagccctcct gtaagctgag agccctgtcc ttaataaccc 27060 tgtcctattg agaatgattt ttcctcttcc tggatcatga atgcttgctc agtgagccat 27120 tgccatccct tgcaaaacag actgaccaaa tgctggcaag gatcagggag acgagtataa 27180 acaggtatag ccacttgcag gaaacccttt ggtcatttct tagaaaatct acatacatct 27240 acctcatgac caaggaattc cacttctaga tattaatcca agagaaagaa aaacataggt 27300 ccacaaaaag acatgtccag ttctatatat ggcagcttta ttcataatat tatgcaaccc 27360 tggaaatatc tcagatgttc attatcagaa gagtggttca aaacattttg atatattcat 27420 aaaatggggt attactcaac caaaaaaatg agacactgat atattcaaca ctgattgaat 27480 ctcaaaaact tttttttcac ctataacgta ttctatgata aacattattt tcaataaaat 27540 aagtcaaaca gataagaata tgcacttcat ttctgtgaag ttcaggaaca gggtcatgag 27600 aggggatgcc ttagaaagga gcaccatggg cctgtgaggt gtcaaggaag ctctgtgtct 27660 ggttttggaa ggtggttacg tgggcacata catctaccag aactgatgtc agcacagtta 27720 ggatctttac ctttcattgt aggtgctttt tttttggtgg aaaatcaaac ttagttgggc 27780 atagtggctc acgcctgtaa tcccaggact ttgagagacc cacgtggaag gattgcttga 27840 gcccaggagt tcaagaccag cctaggcaac atagggagac cctgtttcta caaaaataaa 27900 aaaattaaca ggacgtggtg gtgcacgcct gtggtcccag ctactaggga ggctgaggtg 27960 ggaggattgc ttgggcctgg gaggtcgagg ctgcagtgag ctgtaatagg gccactgcac 28020 tccagcctgg gtgacagagt gagaccctgt ttcacataaa taagtaagta gtttaaataa 28080 ataaataaat acaaattttt aaaaatgtat atctaaataa gagacagggc ttaattacta 28140 ttgcaaacat tttattacct tagcagattg taagggttga aaccaaaact tcaagtttta 28200 cttgtttaga aactccaaca gttctaatga ataaagagga ttataaaatc ctgggaagga 28260 ttagcatatg ctgcttgagg tcacactgct cgttagccat accatggatg atttgcaggc 28320 aacccgtttt ttcctcctaa gcttgaaagc taaaaataga attaaaggtg ataagggcat 28380 caattcccag acagctaagc tgtttaaacc atttatttat ttatttattt atttatttat 28440 ttatttattt gagacagagt ctcactgtgt cacccaggct ggagtgcagt ggtgcaatct 28500 cgactcactg caacctctgc ctcccaggtt cgagtgattc tcctgctgtg gcctcccaag 28560 tagctgggat tacaggcacc ccccaccgcg acctgctaat ttttgtattt ttcgtagaga 28620 cagggtttca ccatgttgac caggctggtc tcgaactcct aatctcaggt gatccgccca 28680 cctcagcctc ccaaagtgtt gggattccag gcctgagcca ccgtgccaag gctgtttaaa 28740 ccttttataa ttgcacattc ctttttagat ataattttct ttctttttta cttatacaat 28800 attaagaggt gcaagtgcag ttttgttaca cggatatatt gcagagtggt gaagtctggg 28860 cttttagtgt aaccatcatc tgagtagcac acattgtacc cactaagtaa tttctctctc 28920 acccctttcc catcctctta ccctccaaag tctccattgc ctgtcattcc acattctgtg 28980 tccatgtgtg cagattattt agctcccact tataagtgag aacatgcagt atttgacttt 29040 ataaattgtt ttacttaaga taatggcctc ctcttccatc tatgttgctg caaaatacat 29100 aattttattc ttttttatgg ctgcaaaata cataatttta ttcttttttg tggctgaatg 29160 gtattccatt gtgtatgtat atatatatat atatatatac acacacacac acacacacac 29220 acacacacac acacacacac cccacatttt ctttactttt atttcttcat ttatttttat 29280 ttcaaacact agtgtcaagg gctttcagta gatcatggcg aatttgcttc tctgctaagt 29340 aggaaaccct gacccagaag caggtgggtc taggacccag aatccaggtt ccccatgaat 29400 gtgtgccacg tgatgggcca gggtgcgact gcatttccag ctgcaccctg tttcccagga 29460 ggagggcctc tctgcactgg accccagtcc tggcattggg gagagtagtc ctctagtggg 29520 gacagtgggg accagccatc cagggccaac aaggcccatg gaggctctgt ggcgctgcca 29580 taggttccac ctgagtggga ttctgacttg gacatgttca gtcataatcc cacagatggc 29640 agattcgccc cattggctcc tcagcacatt ttctttatct agtcatccgc tgatggacat 29700 ttaggttggt tgcatatctt tgctattctg aatagtgctc caataaacat acaagcactt 29760 gttcttttta atgtaatgat atcttttctt ttgagtagat acccagcagt gagattgctg 29820 catcaatggt agttccagtt ttcattattt gagaaatctc catactgttt tccacagtag 29880 ttgtactaat ttgtattccc accaatagtg tataagcatt gccttttgtc tgcaacctca 29940 ccaatatcta ttgacttctt gtttttccac ttttgaataa tagccattct gagtggtgta 30000 agatgaagtc tcattgtggt tttaatttgc atttttctga tgattggtgt taatgattag 30060 tgatgttgag gatttttttc atatgcttgc tggctatttg tatgtatttt ttttgaaaaa 30120 tatgtattca tgttctttgc ccacttttta atggggttgt ttgtgtgtgt gtgtgtgtgt 30180 cttttttttt ttttttttga gttgtttgag tttcttgtaa attctgcata ttagtcctct 30240 gtcgaaggca tagtttgcat atactttctc ccattctgca ggttgtcggt tcattcctgt 30300 tgagtatttc ttttgctgtg caaagctttt tagtttaagt aagtctcatt tgtctacttt 30360 tgtttttgtt gcctgtgctt ttgaggtctt agtcatgaat tctttgccta gaccaatgtc 30420 cagaagtgtt ttccctagat tttcttctag tatttttatg ctttcatgtc atacatttaa 30480 gtctttaatt catcttgagt tgatttttgt atatggtaag agatatggag tccagtttca 30540 ttcttccgca tatggcaacc agtttttgta gcaccattta ttgaaaaggg tatccttttc 30600 ccagtgtatg tttttgttga ctttgtcaaa gatcagttgg ccgtagattt atagctttat 30660 tcctgggttc tctattctgt cccattgatc tgtgtatcta tttttatgcc agtaccatgc 30720 tgttttggtg actatatcct tgcagaataa tttgaagtca agtaatatga tgcctctagc 30780 tttgctcctt ctggacaaga ttgctttggt atttgtgctc tcttttggtt ccatatgaat 30840 tttggggttg ttagacataa tttctaagat atattcaggt ttcacttttg ttctttaatt 30900 ttatgtattt tcttcccaat aaggctataa gcttaagtca aaaattgttt tgcttatagc 30960 tgaagagtcc ctgctttcag cctgccttgt gattttcatc ttgttgcagt tgaattaggt 31020 ttgtggcacc tctgcttttt gtagttttcg tatcaacacc ttggtttttg gctttttact 31080 aattttgttt tttttttttt ttgagacaga gtctcgctct gacgcccagg ctggagtgca 31140 gtggtgcagt cttggctcac tgcaacctcc gcttcccggg ttcaagcgat tctcctgcct 31200 cagcctacca ggtagctggg cctacaggcg cccacctcca tgtccggcta atttatatat 31260 atatacatac atatatatat atatatacat acacgtatat atacgtatat atatacacat 31320 acatatatat acgtgtatat atatgtacat atatatacac gtatatatat atatatacac 31380 acacacatat atatatacac gtgtatatat atatacatat acatatatat atacgtgtgt 31440 gtgtgtatat atatatatat atatatatat atattttttt ttttttttta gtagagacag 31500 ggtttcacca tgctggtcag gctgctcttg aactcctggc ctcaagtgat ctgcccacct 31560 tgacctccca aagtgttggg attacgggcg tgagccaccg cacccaaccg gttttttact 31620 aaattttaaa aattacaagg ttaaaataca atgaaatact caaggaattg cgtgaaccat 31680 ctcttttgta cagactgaga tgactctcct ggtgaccctg aactcgtagg ggcagcaggt 31740 ggaaatgtac attcactact tggtggaaag aagtctgaat tggggaagta tttatacata 31800 tgtgaaattc cattgtacta gggtgtcctg tattttatct ggtaaccctg ggggcagtcc 31860 tatgagctgc ggggcacctg ccctggagac tgaggcaggg agtcaaagcg acatgagatt 31920 ggggataggt tttgcatgtc cgtggaaagg gcttgctgat gaatttgatt tgaagattga 31980 gaaacagagg aatcaagggc gacttcttgg ttttaaactt cagcacctgg tgccctttac 32040 tgagatggag aagatgggag gggagtgggt ttcaagtgtg ttgtgatatg gacaggtctt 32100 attgatgggg tgtggtgggc gtccaaatgg agatgtggaa gtttgattct gagtgagctc 32160 aatatcgtcg tggtgtgttc taccacgtcc cttctagccc tttccgcgct ttctcccatc 32220 tagtgtttcc ctgctcaaat ggaaggagag aggaacaact tagagcacag tgtgactggg 32280 gcaagctacc ttagagataa tcatttaaac accagctaga ctgctgcaag aaaagaaatg 32340 atggtaaaaa taaatgtact ccaaaggaat ttgactaaag aatatttcac cgtgtaacac 32400 atttctgtgt gccccttttg caatgtatca ttaaggatgc attgctaggc ataatgaaac 32460 aaaatgtttt tcgtaatgaa gtggttattt tgcaatgaaa gccagtcaag gaaagaaatc 32520 aggcttgaat actcctagtc acaaccttta taaaatctaa cgttatggtt agactatacc 32580 atgcctgcgc ttaagtagtt tttgaaattt taacccaaat aagaaattct tggctgggca 32640 tggtggctta tgcctgtaat cccgcacttt gggaggtcga ggcaagcgga tcacctgagg 32700 tccaggagtt cgagaccagc ctggccaacg tggcgaaacc ccgtagctac taaaaataca 32760 aaaaattaac tgggcatcgt ggcacatgcc tgtaatccca gctactcagg aggctgaggc 32820 aggagactct cttgaacctg ggaggcagag gttgcagtga gccgagatta tgccactgca 32880 ttccagtctg ggtgacagag tgagactcca tctgaaaaaa aaaaacaaaa caaaacaaaa 32940 cagagaagaa attccttcat tataaggaaa aaagaaatgc acataagcac agttacaata 33000 ttatatttcc tgattaaaaa tatgtattct tttaatggac tacaaatatt ataatttttc 33060 ttaaaatggc ccgtgtgtaa aaagtttatt cccctttact ttacttttat atagtaatga 33120 aatttcataa ttaaatctat attttgtatt atcaatattt aaccactaga agaattgatg 33180 atgctactta ttaaaaatga caagtgatgt aatagagtta gtgggatgtc tgcctgttga 33240 aaccatttta ctaggtaagt atttttatta caaaggggtt ggatataaac tggcctcata 33300 tccaaaaacc tttttgcaaa aatcaaaact ggatatatcc tgtgttcgct tccttttccc 33360 tgggcccctc tgttaaaatc ttttagcaaa aagattttac caaataattc acattgaaat 33420 ataaatagtt ttaaagtttg ctatgttgct ttctttccaa aggtattcag attttagtag 33480 gggacaaaag tgtcccctaa gtcaagtgag tataagaatt acctatattg tttgctacaa 33540 atgcaaatat ccacagcctc cttgtaaagt ctcattcagg ggctgcctac tgcagggccc 33600 aagaatctat atttttaaca aatactctgg tcattcttgg gactagcaaa tctagaaaac 33660 accaacttga ataaaacgat taaagttgtg cttgctgaat ttcaactaca ttaaaggtac 33720 cagtgctgga ggagattttt gaggggttga ggagaaataa ttacacataa attattttat 33780 taatgaaatg attcagcaaa gtgtaaacgc ccgtaatggg cttggcagtg tcctggggct 33840 gaaggtactg agtagaatag gacgtgagac aagtgctcta cttgaaataa gcacagacgt 33900 ggaagaaggg atgtgtagtt ttgtctgggg attcggcaca gtttttatgg aggatgtggt 33960 ctgtgaaatg gctgatttga aacatgaagg aggctgctta tgggatgggt tattctggga 34020 agcaagcaag tgcgagggca ccagaaggta tgaagggcct tggagtactg ggctttctta 34080 tggctgcgag agaggatgag ttggaatgag atgagcagct tatgaaacca ggaagacagg 34140 ttattgtgga ggagtgactt gctaagctct atcagatgag caatgagcag tgaggaaaca 34200 ggggagagat gaaatcatgg ctgcttttgg aaagataagt ggactagcat gcagcatgga 34260 gaatggagag gtggagggtt gttgttggtg tgtgtgtgtg tgtgcacgta tgacagagag 34320 agaaagaaga gggaatatga atggcatggg aaataagaga aaggcaggcc aggtcagagg 34380 gtttttagga tggcctgtga ggtgtaggag ggtctggagg tcggccgtgg agtggagaag 34440 agattgagga ctcaggcact aatctaaggg gaagggggac actgtattct aagggggcca 34500 gtcctgctgc tccctgtaag cactttatgt atttgacatg aaatatactg agatggcccc 34560 catactttag ggtgcaaatg ctcccctaaa gtgagagtgg aagaagaaaa aaggagaagg 34620 cacttatttg ctcatgtgag ccgtgtacag ttccttcaga gctcagagag gcactatgca 34680 gtgaatcaag ccaggtcagc tgctgggact aggggcctgg gtaggtcaca gccctgccgg 34740 ccatccacat gccttccagg aacaccccaa tctctggaac ctttcctgag gcctccattt 34800 tcaggaattt tgttaggaat ccagataaca gaatggccat agtggtgatt atgttccttc 34860 tacctccttt tcatcagcct cgctcacctt acccttccag acatgagaaa acagtttcac 34920 tacaatatcc agtagattta cctaattggt aaaataagaa aggccaagga agttgctctt 34980 ctcttcactc ccacccctcc tgttcatttt gtttgtaaca atagagccaa gtttcaaaca 35040 aatgtagaaa aggtgagcaa tgctaatgat gtgtttcaga tgggattcag ggacaactca 35100 acttgaaatt gtctcttagc catctgtttg tgtgcctggg gtttcacctg ctttgaatta 35160 gggtaattta ataattgtga attagactgg gagagtacaa atggttttgt taattagatt 35220 aaaacgttac attttataat acttactgta ttaaccatgg gctgatgacg ctgcttgtac 35280 cctgtgttaa agccttatct attatctgct ctttcttttg aaaatctctt ttatttcagt 35340 ttccatcgct gtgttgcagc tgtccaacct ctctggcatt ctagaatgga tgctgcctgc 35400 cttccatatt ccaacgcata aggttctttg cctgatgtct tgtgaacata cacaccgcaa 35460 ttccagatac cattaagcct ctgctatcca ggtttattta tattaactat agtttgttta 35520 aatatatttt attaaactct ttaaaaaaat acttctgtga aaccagaacc aaacaaagaa 35580 gtatttgagg tcctggatct ttaaattttg tgatcttggg cctggctcat gcctgtaatc 35640 ccaacacttt cggaagccaa ggcaggcgga tcacctgagg tcaggagttt gagaccagcc 35700 tggtcaacat ggtgaaaccc cgtctctact aaaaatacaa aaaattagct gggcatggtg 35760 gcggatgcct gtaatcccag ctactttgga ggctgaggca ggagaatctc ttgaacccag 35820 gaggcggagg ttgcagtgag ctgagattgt gccattgcac tccagcctgg gcgagaagag 35880 caagactccg tctcaaaaaa taataaaaaa ttaagaaaaa taagtaaatt ctccttacat 35940 ataaaacata tgaagcagtg ctgccaaaga gagagagaga aagagaagga aagagagaga 36000 gaagagagaa agagagcgag cgagcgagag acatcgagga taagagagaa caaagatgat 36060 gatttctgaa aaaaaggaat ggatattcaa taagcctgta cttactatca ccataagctc 36120 taagatatga catgagtatg tttctatttt aatacctcta aactcacaat taatggcatc 36180 ttaatatttt aaagggtagc cattgtttta aaagcatata aaataatggt ataaaaatta 36240 gagctatctt aagttcagta aatatagaac tttgagtaag tcaatttgat aattcccctt 36300 tatggtaaat tatctcatga tagtttcatg tttaactaaa tcttcagaaa aaatttttat 36360 tgagatgatc attggctaaa aaaaatggtg gtatttgatt ggttttaaag agacacttat 36420 tttgtttttt gaggggaaag tgaatattga gaaaaaatag tgactgtgtt caatgttacg 36480 cttttaacat cagtaaactg caactgacaa ggctgtttcc tattacctac tgttaaatgg 36540 ccctgttttc taacttaaaa atggtgcttc taaggctaaa ccttcaattt cttctggact 36600 ttgtcaggtt actttgggtg attttgaaag atttccatac ataatactgc tctggaaggg 36660 tgcgtgcgaa tatggttcac aaaagcagtg aagacatgta tctacaccga ggacagcatg 36720 tgagctacac tgcaacaact gttttagatg gccagcctgt gtttgacgat gatccctgag 36780 tgccagatgt gaaggaaaat ataaatccct caccatgtcc tgaattccac aatgcctctc 36840 cctcctcccc tgggagtgga gccaggctga cctctctctg gctccatact ggaaatgtgt 36900 gtggcaatgg cagcattgcc ctttacccca tgcccaatac tgcaatggca ccttaggctg 36960 tgtgtgtgtc agacagaaaa ataaaacatc agatttttgt taattttggg tgatgagtga 37020 ggtcagggat agttattatt ttgagactgc tatttttttt tctctttttt aaaaacagat 37080 ggggctgggc acaatggctc atacctgtaa tcccagcact ttgggaggct gagggaggtg 37140 gattatttga ggccaggagt tcaagaccac cctggccaac acggtgaaac cccgtctcta 37200 ctaaaaatac aaaaattagc caggcgccgt ggtgcatgcc agtaatccca gctactcagg 37260 aggctgaggc acaagaatca cctgaaccca ggagacgagg ctgcagtgag ccaagatcac 37320 actattgcac atcagcctgg gtgatagagt gagattctgt ctaaaaaaaa aaaaaaagag 37380 agagagagag aaagatggga tcttgcgctg tcacccaggc tggagtgcag tggtgtgatt 37440 gtaggtcact gcagccttga actcctaggc tcatgtgatc gtcccgcctc agcctcccaa 37500 gtagctggga ctacaggcat acaccaccac acccagctaa ttttagtttt ttgtagagat 37560 agggtcttgc tatgttgccc aggctggtct tgaacttttg gactaaactg atcctcctgc 37620 ctcagcctct cacagtgctg ggattatagg catgaaccac caaaaactgc agtttaaaag 37680 tgtttatatc ctggatacac taacagcatt ttgtccaact tgtggagtgg agggagtagg 37740 gaaggggagg atagtgctaa tgaactgtga caggggctag caagaaagaa agaaaaagag 37800 ttccctaagt aagctcctac tgggtgtcct ccactcacat ggagacaggg ccctgccttt 37860 taggcactta ctcttccagt gtctattgca taatatgttc aggaaggatc ccagattcaa 37920 agatttatag aattagagtt aaaagggata gatatcttgt ttgaccctga aaaaattaag 37980 gaatatgctt gagatattca atggcagagg ctggaataga ttttcccaaa tctcctgatg 38040 tgaagttctg tgtttgtcaa acatgactgt gtaaaaagat taatttaaac ttaatgacat 38100 gttgtattca tagaagttct ttgggtttct gtggaaacct cctcttgcta gcttaagcag 38160 aaatggggga tttattggaa ggaagctgag atattgcacc aaactgcaca aaattgaatg 38220 aagagctgac taagcaaggc tgcactgaga aggaaccagg gtggtctggg ctgtggtagc 38280 ggcagcagca gcttgcagat ctcccagcgc tgatgctggc tcgactcaga caggtctcca 38340 ctctctgctg tctgtctctg gctcagacag gacactttgt gtggctgttt ccttccacaa 38400 ggcctcagtg ggagcaagcc agcctcccac aggcctctga gacagaccac cccattcctc 38460 cctctcctgt taacctgcct ttatttcctt aattgcactt atcaccatgc agaagcctat 38520 gtgtttgttc ccctgtggag atgtaaaaac actgatgccc aggcctaact cccagagact 38580 ctgattgaac tggtctgggc tatggagccg ggacatttgc atttttctta caagctctaa 38640 tgtgcagcca ggattaagaa tcattgcctt ctgcatcaac aggacaaata caaaatgtgc 38700 agcaaaatat atgtttaagt gaatcaagaa gacagatcta gaaacgattg ttaaggaata 38760 ataatgcatt ttgtccatca ccacacataa gtgatgttga ccagagccct cccagattga 38820 gtggtgccag gtgttcgggg ttgtctcggt taatccttac tatggccttg cggggtaggg 38880 ggcagtgtcc tcattgtcca aatgagtcac tgaggctgag ggattcaggc tcagtgtatg 38940 cccacagttc tttggcaaac cccaccactg ggccagccaa ctacacgggg attctgatcg 39000 ggtcctgatg ggtgcccatg atgggctgtg caaaagtggt ggtgagattt ctccaccttc 39060 acggaggtgg tacccagggg aggtggactt cagcagcgag aatgggctgg gtgcagtggc 39120 tcacagctgt aatcccagtg ctttgggagt tcgaggcagg agaattgcat gagctcagtt 39180 gttcgagacc atgggagacc ctgtctctac aaaaaaaaaa aaaaaaaaaa aaaagtgata 39240 gtagtcagac attcccgaca ggcaggactg ttgaatgttg gtctgtgtta ccaggagata 39300 acacatttta agcagaaata ataggggaga aagaggatct caattatttc aagaaaagca 39360 ggacttgctg ggctttcagg gctaattaaa ggaaatagga aaagtgaaca tgtgtgagaa 39420 tctaaaccta acagttgttt attgaaaaga agagaaagag tggagaggga aatgaagttt 39480 tgatttttgc ctttttagga aattgggata taatttagtg ttcgtacttt aagttagtgt 39540 agagtttgag tgagaagaat gaggaacata aatatgaatg ctctgttaat atagtgcttt 39600 tcatagaaat aatggaatag aatacgcttc actgccgggt ctggaaaccc tccctctgtc 39660 agggtgattt agaaattgac tgattttacc atggagggat gggatgggcc acaggctggg 39720 gtttgaagaa agaatctata atccttttgg tcttaactat taggcaaatt tagcttcctg 39780 gtctcagaaa gaaaaaacac acccacaaaa agaaaaaccc atgcccgtgg gaacaagtaa 39840 cttcctcctc ctggggctgc ttgaaaaccc taatcttcct ctcaccaggc caagtccctt 39900 cccttctcag cgggaggcca gctggggcat ccaaaaagcc acaacgggcc ctggggaggg 39960 agaatgcacc cgtctgggtg agcagttgaa cgtgcattgg ctgaggtgtg aggctcggga 40020 aatggctctc caggcaaaga cgctgcttgg aggcaacttt ataattcttt gtacctggga 40080 aagtgaaggg ttgggcgggg ggagtggggg tgggagcttt gtcacgtgac cccactcttt 40140 gcttctttgt ctgtcctcca acttaacatg gcttgaggct gaaaaacaga attcctcatt 40200 ttttactcag tgacaaaatc agagaaaaaa gtcaatgcca attgaaaaag acatctgcaa 40260 acatagaact gttttttctg ccaaatatgt gagcatgggc tgtaaatata gtaaaataat 40320 tcagcagatt aattgtggga aggccagtgt gagttgggga agaatctgaa acctggacca 40380 ctagaattcc agtaaagtga agagagggat agaattgagg tagagctggg ggacttgggg 40440 acgcatcaga cattatctgg agtgctgtga aaattacacc gctttctttg ttagcaggat 40500 tcccattcat aaagcctctt tagcaatttt tgtttaacaa ttttgtttgt gcagaatgtc 40560 acagcaacat ttcttaagtg tgatcatgtc actataacct ggctttcctt gttttggagg 40620 acgggggcgg ataatgggaa gtaacgcatt gtttacttgc tctgagagag catttaacat 40680 atgctatttc atttaatcct catggtgacc cctgatggag gactgttatc tacccttcac 40740 agatgaggaa aatgaagttt aatgaagtaa cttgcttatg tttatatgtc tgttaataaa 40800 tggaagaaca aggatagacc caatttcccc tcattccaaa gtcctttgct gctttacttc 40860 aggaaatttt ttttttgaga cagtatctca ctctgttgcc caggctggag ggcagtggca 40920 taaatcttgg ctcactgcaa gctccgcccc tccccccctt gcccttcccc accacccccc 40980 caccgggttc cagcaattct cctgcctcag cctcagcggg attataggca tgtgctacca 41040 cgcctggcta atttttgtat ttttagtaga gacagggttt caccatgttg gctaggctgg 41100 tcttgaactc ctgacctcag gtgatctgcc cgccttagcc tcccaaagtg ctgggattac 41160 aggcgtgaac caccgcaccc agccaggaag atttttaagt aaaagatttt cagcccacat 41220 tctttgaatg atcacagatt atcagataat gggggacatt ttgtttgttt tcatcgtcta 41280 gatacgtctg aaacgaaaac aattttggga gttaacattt attaatcatc tattataaac 41340 caaatacatt gtagctaata attaaaatat attctattac ggaattgctg ctgaccacaa 41400 actatggaat aagcacgtgg aatttctaag ttcactttaa ttcaacaact ggtgctttgt 41460 tgctgacttg gtaaccaggt ggcccactgt gtatgtttta ttgaagcaag ttgtctgcaa 41520 agaagcggga tagacagggt ctgtcctcaa ggggtttaca gtctatcgag gagagagcta 41580 tacacgtact aactgataga cacctctaga gttacataac agacataaag ttgtacataa 41640 cagacataaa gttgtactat aagagatgtc ctggggcttg ggacgaaatt ccaaattgat 41700 tgtggagaga agaaatctga ggggagaagg atgtgggctg ctggagacca ggcaagatgg 41760 gttttgagtt acgtttggaa gacaggtgag atttgcataa atgggtagga gtgcatgagc 41820 caagatgaaa aggcaggtga tgccaccgtg ccaattagga gtctaacatt tggagtaaca 41880 caggtgatgg tgaggcaggt tgaggccagc ctgggagagg cagggagggg caggttgaat 41940 atttcaggtt ttgtcctgtt ggcaggagtg ttgatagcag tattacaaat gatggtatat 42000 tagtaataat aatgtttaaa atgtattgag catttactcc actggatact ctttattcca 42060 cagatattta cagagcattt acaagtgccg aacaatgttt cttgcactga taatacaagg 42120 gtgtgcaaaa ctgacaggaa tccctgctct catggagctt acagtaacag aggagcgatg 42180 gacagatgat aaaataggta cattcttccg tgggtgctgt agggaagcat aaggaaagga 42240 gtgggtggag aatgaatgga taagggagat cacagtttca tttttatttt ttctttgggc 42300 agagtctcac tctcactcag tctggagtgc agtggcataa acacagctcg ctacagcctc 42360 aacctcccag acacaagcaa ttctctcacc tcagcctcct gagtagctgg gcctacaggc 42420 atgtgccacc acgcccagct aatgtgttta aattttttat agagaggggg tctcactgtg 42480 ttacccagac tagcctcaaa ctcctgggct caagcgattc tcctgcctca gcctccccaa 42540 gtgctgggat tataggcatg agccaccaca cctggctgac atcacaattt taaagcctgg 42600 ttctatgtgt gccagtgtat taatttatct aatcaggtaa ataataggta gaagacagtc 42660 tccgaagaat tataaacgta ggctgggtgt ggtgactcat gcctataatc ccagcacttt 42720 gggaggccga ggcgggtgaa ttctcaagag ttcaagacca gcctggccaa catggtgaaa 42780 ccccatttca actaaaaata caaaattagc cgggagtggt ggcacacgcc tgtaatccca 42840 gctattgggg gagctgaggc aggtgaatca cttgaacctg gcaggcggag gctgcagtga 42900 gctgagattg tgccactgca ctccagcctg ggcaaaaaga gcgaaattcc atcaaaaaaa 42960 aaaaagaatt ttgaatatga agtaacatga aaatagaatt cataaagatg agtgtagcaa 43020 aacgggaggg tgccagctgg gaggcaacct cagcaacctg ggatggttag acgtagcagg 43080 gctgttgtag caattaatat taggtagggt ttagtagaga aaggagacca atatagggaa 43140 aagaaatcaa aactcactat ctgctccatg cctttccgag cctagaatcc aagtgcaatt 43200 atatcgcaaa actgacaggg cttgagggag ggtggaccta atgagtaaaa tgtgaagcga 43260 aagtgacagg atgactgagg gtttgagcct cgggtgactg gaatggtgag aaaaaacaat 43320 tttcagtaag gaagatggaa attcaataga attgtctgtc atactattta agtaatttaa 43380 aaattttttg aaacgaattg ggggtggcct ctaaggtact gatcctttct gagagtcagt 43440 agtttctcct aatggcagtg cgggcaatgt gagagataaa gcaggtgggt cccggtgcca 43500 ggagaactgc ttccccttcc cagcacatct gctcagtttc cgcctctctg tcaagctaca 43560 cctgctctgt cctaacctgc catccactgc ttcccacttc caaaaatttc ttgcttacag 43620 attcccaaat atgcttgctt cacagcattc tgagtgtcta taattttttc aaggcaaccc 43680 gacagcagaa aaaatacagg agagtttcag ttagtgaata tttaggtcaa acaacttttt 43740 tttttgagac agggtcttgc tctgtcccca caggctggag tcagtggcac aatctcagct 43800 cactgcaacc tccgcctcct gggttcaagc gattctcctg cctcggcctc ttgagtagct 43860 gggattacag gcgcctgctg ccatacccac ctgatttttg tatttttagt agagatgagg 43920 tttcaccatg ttggccaggc tggtctcgaa ctcctgacct caagtgattt gcctacctcg 43980 gcctcccaat tgttgggatt agaggcgtga gccaccgcgc ccggccaaga tcaaacaact 44040 taataaatgt ttgttataat gacttagtgc catttgaaaa aaaaaaatac acatacattg 44100 aaagaaaaat atgtttttat attattctta aatgaccaca gttattctca aatgggatgt 44160 gtacaccctg ccgcacaact tctccaacct tagaatcata ttggacaccc acattctcac 44220 tttctggtgg tacttgtttt ttctttttct ttcttttttt tttttattat agcaaccaca 44280 gaaaacccag ttttacaaat atatgctgct gttgaaagga agatagcatg atctaatgtt 44340 gaaacagcac taccttgagt gagtacctct cacgatgtgt gagagatgtc attgtgtttc 44400 ccttgaaaat ttgaaatatc ccagggcacc tctgtgactt caccatggca ccgggagggc 44460 ctcaaaacac agtttgggaa tcatggtaca ggcctgttct ataccatctg ttttccttct 44520 caattttatg gcacttcttg gcatcctcat tttttttttt ctttttttga gatggagtct 44580 tgctctatga tccaggctgg agtgcaatgg tgtaatcttg actcactgca acctccatct 44640 cctgggttca agtaattctc ctgcctcagc ctccctagtg gctgggatta caggcgtcca 44700 cccaccatgc ccggcttatt tttgtatttt tagtagaaac ggggtttcac catgttggcc 44760 aggctggtct tgaactcctg acctcacgta atccaccccc cttggcctcc caaagtgctg 44820 agattacacg catgagccac cgcgcccagc tgcatcctca tttttaagaa aataactgga 44880 tccagccatg accttccatt tcctcttttt cacctttaaa ctcctagagt gagtttacag 44940 tgactctcca gttcacttct agtatcatat actgcagata tgtcacttgg taagtcactg 45000 ctttggcttc aagcttagtc caaagaatgg tttccctttt gtttgttttg agatggagtc 45060 tctctgttgc ccaggctgca gtgcggtggt gcgatcgtgg ctcactgcag cctccgcctc 45120 ccaggttcaa gcgattttcc tgcctcagcc tcccaagtag ctgggattat agacacccac 45180 caccacacct ggctaatttt tatattttta gtagagatgg gatttcacca tgttggccaa 45240 actggggtga tccgcttgct tcagccttcc aaagtgttgg gattacaggc gtgagccacc 45300 gtgcccggcc tctttttttg tttgttttga gacaggttct tactctgttg cccaggctag 45360 ggtgcagtgg tgcaatcacc gttcactgcc ccctcaaact cctgggctca ggcaatcctc 45420 ccacatcagc ctctggagta gctgggacca caggcgtaca ccaccatgcc tggctaattt 45480 ttaaattttc ttttgtagag acgagtctca ttatgttgcc caggctggtc tcgtactcct 45540 ggctcaagca gtcctcccgc ctcacctctg aaagtgctgg gattacaggt ccgagccact 45600 gcgctccacc agaatgtttt ccaattctca ttccaccata tttcttttgc gtttaaaatc 45660 cttggctagg ttcaaattat tgcctggctt ttgaccttca tactttacca caagctcatg 45720 aatatgccag gccttaaggg agaagggctt tctatgtctt tgtcttctgt gaacccattt 45780 aaactccacc acagccatgc ggggatgggc gttattatta cctttttcat gggtgaggaa 45840 gcaggccgcc cgtgacacca aggcatcaga atggaacgga aacaccatct agaggtgctg 45900 cctgtccaca gttatggcca ggttcctgag gacaccctgg acgctggtga ctggtataaa 45960 taagtgtctt gctgtgtttg atttttaatt tttacaacta tatttttata aaagtaaatc 46020 attatagctc attgtggaca ctttagcaat gaagaaaaag aaaaaccaac tcaccacaga 46080 agcatacaag tgtttatgta aaaatttttg attcagttta atttgatttt aatattgctt 46140 ccaaacattt ttattatgta atcataatgt atataaaact ttttatcttg ttttataaaa 46200 attaaattat aagcattttt tatttaatta cacaattatt ttagccatcc ttaagaaatc 46260 tttatcactt tcaaggtgat tcttgcacat aatttaaaaa ccaaataact acaaagcttt 46320 aacataaaac agcagattcc tgccctacct tcctgaagcc tctcccacgt agatttaccc 46380 cccagatcca accacttcct tatcttcaac tcagtggctc tattatatcc attgaatggc 46440 atcatgcagt ttgtgtacct gctgcccatc ctgtgtttac ttaattgagt tactgaatgg 46500 ttgattgaga gcaatggttc tgcaggatta gtaaacgctg ataaaggcct gttgactatg 46560 catgtataga tgtgtaagtt cagagctaca ttatcagatg tactttgcct tgccatttta 46620 taagcctaat ttaactgtgc atttctttta tcataaatgg ctatgggcgt attaggagtg 46680 atgactttat tattaaacat taatagatct cccagctctt atcagttatt ttctgaacct 46740 aaaattgaag aagtttggga attaagccaa gaagatctaa tgaaattcta ttgtatttta 46800 aaccataatt attaagacac agcaggtaac ggcctgccct tgataattgt aaagactatt 46860 gggtgttaag aagaagcaca ttatgtggat acatgcaact tcttgtagaa atattttcag 46920 gcagccctct ttttaaaaat ggaggatccc ttttcagaaa tactgattcc caagcatgtg 46980 ggctggtgtc tgtgctgcca caatatactt ttaaaaaaat taatagactt tattttttag 47040 agcagtttta catttgtctg ttttttactg ctccttgtgg agcccggcta actcctaggc 47100 agtgcgccca gagctgcagt tttagattca gataaattag gcagaaatta cagataattg 47160 ccatctagcc atcactgact tcccaccctc aaccagctta ttattaacat ataattaact 47220 cctgtaatga acatgttaca ttagtgtggt acatttgtta tcactgataa gccaatgttg 47280 atacattaat taaaatctac agttttcatt aggattcact cttggtgtag tacatttcat 47340 ggattttgac aagtgtataa tgacatgtat tcaccattac agtcatatag aatagtttca 47400 ctgccttaaa aatcccccat tcttcacatg tttattcctc tattcccgaa acctctggca 47460 accactgatc tttttagtgt ctccatagtt ttaccttttc cagagtgtca tacggttgga 47520 atcacacagt atgtagcctt ttcagattgg cttctttcac ttagtaatat gcatttaagg 47580 ttcctctatg tcctttcatg gttgatagct tatttctttt aagcactgaa tagtgttctg 47640 ttgtctggat ataaaatgga taaatatttt atttatccat tcacctaatg aaggtcatct 47700 cagtagcttc caagttttgt caattaggaa taaagctgct ggccaggtgc ggtggttcac 47760 gtctgtaatc ccagcacttt gggaggcaga ggcaggcgga tcacttgcag tcaggagttc 47820 gagaccagcc tggccaacat ggtgaaaccc tgtctctatt aaaaatacaa aaattagctg 47880 tgtgtggtgg cgggtgcctg taatgcccag ctactcagga gactgaggca ggagaatttt 47940 ttgaacctgg gaggcagagg ttacagtgag ccaagatcac accactgtac ccctgcctgg 48000 gtgacagagc gagactctgt cccaaggggg aaaaaaaaaa gaaagaaagc tgctataaac 48060 atctatgtgc aggtttttgt gtgtacatac gttttcaact cacttgggta aaaatcaagg 48120 ggcacagttg ttgggtcata tggtaagggt attgtttagt tttataagaa actgcaagac 48180 tgtcttccag aatggttggg tcattttatg ttccccagca atgaattgga gtatctgttg 48240 ctctgcctct ttgccagcat ttggtgtagt cagtgtttta gatttttcct gtttaatagg 48300 tatatagtag tagagtatat ctcattgttg cttggtttgt tcgttttgtt tgagacagaa 48360 tctcgctctg ttgcccaggc tggaaagcag tggtgcaatc tcagctcact gcaacctccg 48420 cctcctgagt tcaagtgatt ctcatgcttc accctctgga gtagctggga ctataggcaa 48480 gcgccaccac gcccggctag tttttgtatt tttagtagag atggggtttc accatgttgg 48540 ccaggctggt ctccaactcc tgacctcagg tgatccgccg accttggcct cccaaagtgc 48600 tgggattaca gtcatgagcc accacgcagg gcccattgtt gctttaattt gcaattccca 48660 ggtgacatat gatatggagc atcttttcat gtacttattt gccatctgta gctcttcttt 48720 ggtgaggtgt ctattcagat ctgttgccca ttttaaaaat caggttgttt gttttcttat 48780 tattgatttt aagagttctt tgtctatttc agataccatt cctttattag atatatattt 48840 tgcaaagatt ttattttaat ctgtggcttg tctttttatt ttcttaagaa agtgtctttc 48900 acagagcaga agttttagat tttaatgaag ttcaatttat aattttttct ttcatggatc 48960 attttttctt tcatggatca ttttttcttt catgatcatg gatcattttg atgttgtatg 49020 taaaatgtca tcaccaaacc caaggtcatc tagcttttct cctatgttat ctcctaggag 49080 ttttatagtt ttttgttttt cctttaggtc tgtgattcat tttgggttga tttttgtaat 49140 agatgtaaga tccgggtcta gattatttat ttacatactt atttatttac ttacatgtgg 49200 atatacagtt gttccagtac cacttattga aaaaaatatc ctttcagtgt tgaattgtct 49260 ttgctctttt tgaaagatca gttgactata tttgtgtggt tctatttctg ggctgtttat 49320 tctattcata tgtactgagt ctttttgtta ctttcagtga agataaaatc tatttgtagc 49380 taatcttggt ttgtctttga ctcttagttt cctcatgaga agcagggatc cgtagaatag 49440 atccttctta ctgtttcttc catctttact gcgtgagatt agtgagacta agtgagacta 49500 agacttagtg agactaagaa tacagtcggg atgatgcttt tctcatagaa aatctctgga 49560 tctgtttcaa cagctaccag atctgtgtat gtgtctttgt gtctgtctgt gtgtgtacag 49620 gcatagtggc agatgtgatt tctggttatg tcctttacat tttataacag gatattaaac 49680 ttaacattca tgaatgagta agaaagcata ttttgcccca atctgtaaca gaaaatatca 49740 ataattgagt tattaccagc aattaaaaca tcagatttcc tggcatgaag ctttcataag 49800 gggatatttg gcaatgtttg aagacatttt tggttgtcac aactggtagc tgggaggcct 49860 ggagaggtgc tactggcatc cagtgggtag aggccaagga tgctgctaag tatcctacaa 49920 tacacagaac tgtcctctag aacaaataat tttctggctt gaaatgtcag tagtgctgag 49980 gttgacaaac cctgttgtag agaagcagat ttatttatat ccatggatat gttttcctct 50040 ttgccttgtc ctctagatca ggcatcccca acccctgggc catggactgg tactggtctg 50100 tggcctgtta ggaactgggc cacacagcag gaggtgaaca gcagttgagc aagcattact 50160 gcctgaactc tgtctcctgt cagatcagcg ccatagtaga ttctcatagg ggcgtgaacc 50220 ccatcgtgaa ctgcacatgt gagggatcta agttatgtgc tccttgtgaa acagtttcat 50280 cctgaaacca ccacccccca cctgaccccg ctctgtggaa aaattgcctt ccatgaaacc 50340 agtcacggat gctaaaaagg ttggggacca ctgctctagc taacctagac tcctgatgat 50400 ttgccatcta tagctaataa gcagcagaag cttatggtgt gatacaacat tccacttctt 50460 ttaggtgtct tgagctgagt ttcacttttt tgtaatttca taataatttc tattatgtta 50520 catgcattta gataagctga caactcttaa agtgggacat aaatacacta ttatatgtat 50580 ttctgaatat gggtggctgg attgttgatc ataaaaatct gaatctggaa acaaagttga 50640 tgtttaataa ctctccttgg ttggctggat atacataatt cagactctgc tttgaatgtc 50700 cccttctggt cctttaaatg gtctatttcc ctaccttacg taagtttcca tgagctcatc 50760 ttgttttcat agtgttccct tttattgtta agagaaacaa aaccaaaaaa ccccacttgt 50820 ttcagcaatg ccctgttgtc ttcctctgtg tgaaattgct caactaagag ttatgcaaat 50880 ggggatgcgg cacgtggtgg aggcttcttg cagcatgttg atgggggacc aagacctggt 50940 cttgcctctt cctcctcccc ctgctggctt cattccggtc ataccagctc ctgctgtggc 51000 catcagctca tcccaggacc ttggcagggc ctgtttcttt tacctcacac tgaagcccca 51060 aactcttagg ctccagtaat cctcccagct tggcctccag tgcactggga ttagagatgt 51120 gagcccccat gcatggctac tctctaagtt cttactccca cggacaatta gagtttgaag 51180 gaccttaggc catgggttca gattatctta ttttgcttca aaattttaaa aactttttta 51240 tttttctgtc atatacatat acgtgtgtgt atatatatat aagttatata tatataactt 51300 gtatatgtta ctttttatat ataataaaat atattatatt tttaaataaa atatattata 51360 ttttaaaata taatatgtaa ctcgtacata gcacatatta tatgtaatgt atcctataca 51420 taaccttatg ttgtacataa atatgtatat tgtttaccta ttgtactata tgtacatgta 51480 taacttgtct atgtattatg tattataata aaatacattg atacttgtat acataatttg 51540 tacacaatgg aaaacatttt taaaatttta gactaagggg aactgagcac aaaacctaag 51600 ggcctcgaaa ctctgatttt atacatatat aaaattatac atatatgtat ataaaatata 51660 ccttttaaat aaggtatata tgatgggaaa attaaaaatt tgcaagggca aaaccaaaaa 51720 tagctgtaga tgaacattgc ggtagtttag cctatttctt ttcagacttt tttctattca 51780 tttgtacctt ttccctcaca aaatgatatc atgctatata tactgttttt acattttttc 51840 acttaaatat attgtgaata tctttttatg tcaataaata tatatgtatt aaaatttaat 51900 agtcacttag tattcttttg tgttgaagta tcatgttcta gatcaatttt ccaaaagcca 51960 gttaccagaa gggcaatttg atgttttctc aaatgttaca ccgtaccaga agacttgttt 52020 cttttaacta cttgaatatt atttttattt aaaaaacttt atgcattttt aatgtgcttt 52080 tgctagttct tcaaatgaca tatcaacatt gtttctgcaa ttagaaaaaa taaaatttaa 52140 atttataagc ctcaaaaaga aattgtaagt gaccaaatca tttccaacac atatgacatg 52200 cttaaacttt agtttctgag aaggtgaaat taggatgtgt taacctggca gctgtttgca 52260 aaaccatttg agttgaaagg atagaaccat cctgaaataa ggaaaggaag tgttcctgtg 52320 catagggata ccagaaagaa gcagaagact tgaatctcaa atgtaataaa agatgacatt 52380 aaggttgaag aattttttaa aaattaaaat tctaaaaatg taaggagagg taaagcaaga 52440 agtgaattag gaaactacag aaacaaccat atctcacatt aaacttaagc tactaattac 52500 tagtgacaga ttaatatagt tctaagaaga ctcaataatc cttagctttc taaaaaatag 52560 aacatttgtc aaaatctttt aaaacaatta tatatatatt ttttgtttgt ttgtttttgt 52620 ttttttttag atggagcctc actcttttgc ccatcctgga gtacagtggt gctatcttgg 52680 ctcacagcaa cctccacctc tcaagttcaa gcaattctcc tgcctcagct cctgagtagc 52740 tgggatcaca agcatgcacc accacgcctg gctaattttt gtatttttag tagagacagg 52800 gtttcgccat gttggccagg ctggtctcga actcctaacc tcaggtgatc ctcctgcccg 52860 ggcctcccaa agtgctggga ttacaggcat gagccaccac accaggccta aaacaattat 52920 atttgataag aattattata ctcgcattta tataccaggg aatactacac agccataaaa 52980 aatgaaatca tgtcctgggc agcaacatgg atgcagctgg aagccattat cctaagtgaa 53040 ttaatgcagg aacagaaaac caaattgcag gctctcactt atgaatggga gctaggcatt 53100 gaatacatat ggatgtaaag ataggagcaa tagacacggg agactactaa agtgggggag 53160 ggagaagggg agacattcac caaaaaacta tttggtacta tgctcactac ctggatggtg 53220 ggatcatctg taccccaaac ctcagcatct tgcaacatac ccatgtaaca aacctgcaca 53280 tgtattcctg aacctaaaat aaaagttgaa attattttta aaaaagaatt actatactct 53340 taagctatga aagcaccaca actaatacca actgttataa acttaagctg ttaaaactat 53400 cccatctaat atgacattac gtaaatctga aataattaaa agataccaat tttggtgaac 53460 tgatcatctt gtaagttgaa aaccctcaca gaactggctt tggtgatgtg aattttgaga 53520 gctgatctgc atttatttaa ccagtgacct ataatttgac aaacaagcct atttctatat 53580 ggtattccaa acagtcccac aataagtatt ctcttgtata gaactttgtg tagcccccag 53640 ttattttctt ataagtaatt tattccaaga agtggtcatg ttgggttaag aagtgtgtac 53700 attctaacgg agtttaatat gtactgtcaa gttaaagatt gtatcactta tcctctcatg 53760 ccaagcccag tgatttcatt ttatggtgag gcaattacag tccagagaaa agagtggttt 53820 tgtcgataat tacaggactg tcaaggctgg actccacaga caggcttcct gagttcaaca 53880 ctgtctcatt atcctctttg cactcccttc caggcagagc cacatttccc tttcagtttc 53940 tctgttctag atgccaatct tccatatacc tctttaattg tcttgcaatt cttttctgga 54000 aacattctag taaatgcagt gattaaaact gtgcccagtg ctgctgcccc ttcacattgt 54060 ggataactag atgaccctgg gtctacctac ggctgtgctt atgtcttgtg gcaaataata 54120 aagaaggagc tttggccagg cgcagtggct cacacctgta atcccagcac tttgggaggc 54180 caaggcgggc ggatcacaag gtcaggagtt cgagaccagc ctggccaata tggtgaaacc 54240 ccatctttac taaaagtaca aaaattagcc aggcatggtg gcgagcgcct gtagtcccag 54300 ctactcagga ggctgaggca ggagaatcgc ttgaacccag gaggcagagg ttgcagtgag 54360 ccgagattgt gccattgcac tccagcctgg gcgacagagc gagatccgtc tcaaaaaaaa 54420 agaaggagct tcaaatcagg taaacacagc aaacagaaga taaaaagaag ttggcaaaca 54480 gcttaagttt gccaacaggg tttgaatctt ttcaaatgta gtctgtcttc catcattact 54540 gtttcttctt cttacccgct actcctttgc aatcttgtgt ttaggtaggt acagggttgc 54600 tgctgtgctg tttggtagaa agaagccata ggttctctcc atattctgtg tatgccgttc 54660 accggcccgc taagatttga ctgggcactg ctgattcgag ggatgttaaa tggacaccca 54720 ccgtgcaagt gcatgcaact gggaaacttg tggatctcct ggaaaccttg acaggcagaa 54780 tgaggggagc cctgggacag catctggctg ttttgtcttg acaccccttt cctcagtgct 54840 caaccctgca tgagacatga agagaagaga agagccaact ccttattcag acccagagac 54900 atccctcctg tgttgagggg ggtgcaccct gtaactagct agctagtctt aaacccactt 54960 cccacctcac ccccctttcc caattgaccc tcaatagtca aagtgaatgg aggctggcag 55020 gcaccttgga cacaggttct atcccagtct ttactctttc caacactcct tcagacacct 55080 ctttctcact tctcctaaat catatcctcc tcccttctag ggggagcctg atggctcacc 55140 ttagtcacag acaggagctg acacctaacc atcgaagcag ctctgtggtg gaggtgatgc 55200 ccacaccatg gacggaagca gctccacggg ccatggtcat agcctagagg tgacgcccac 55260 accatggagg cagctctgtg atctgaggga ttcccggcac cgaaacagca ttgccttaat 55320 tgcccccaaa cactgttcct attacacatg acatttaaac cttagggagt tacattcata 55380 atgttaggtt gcctaaagaa aaaaaacaaa aacaaaagca aactgaaaaa gccttaagta 55440 gggccttatg ttgcaggctg gtcagataga gaaagccgtg ctatgcagct tggccagccc 55500 gggttaccag ctcaccaact gtgcccaccc tggctgctgg gagattttat tgaggaaaaa 55560 tattggagaa tgtttgaaaa taatgaccat ggtatgtaag gcaaaaaatc ttagttgttt 55620 aaataaagac ggtctggcta ggtccttttc agttctctct cttttaaaag tgatttaggt 55680 gctgggtgca gtggctcacg cctgtaatcc cagcactttg ggaggccgag gcgggtgtat 55740 cacctgagat caggagttgg agaccagcct ggccaacatg gtgaaaccct gtctgtacta 55800 aaaatacaaa aattagccat gcttggtggc ggacgcctgt agtccccact acttgctact 55860 caggaggctg aggcaggaga atcgcttgaa cccaggaggc agaggttgca gtgagccgag 55920 atcgcaccac tgcactccag cctgggcaac agagggagac tccatccaaa aaaaaaaaaa 55980 aaaaaacagg aatttgggaa aattgatgca agactgaact gcttgagttg ggaattaatg 56040 gagttggtgg tggagcttag tgctagtgcc ctcaccaagt ctctccagca ctgttgaggc 56100 tgccaaccag gctattgtgt ccccatgtca ctttgataag cagtttggag aaagcattca 56160 actcttctga agactttgtt tctctaatct gagtctcctt tccgaaagta aagtaagaag 56220 gacaattaaa gggtatctaa aggtttctgt gttggtgggc aaagtaaatc tcttgagtta 56280 tagaactgat actggaatgc aagtgtgtag ggaacatact tttagggacg aattcctata 56340 aatgatgctt gaaccagtct tggacctaat ttgaaactca agatcacttt tgtttcagat 56400 agacaccacc cacctctatt tccccaggct tcctttctct tcctcatgtc tttctaagct 56460 ctctaattca gaaaactcat ggatctggag cttcctccac agaaaggcag caagaccttg 56520 catcagtaaa gaagtgcagc ttttaggctg ggcgtggtgg ctcattccta taatcccagc 56580 actttgggag gctcacgtgg gaggatcacc tgaggtcagg agttcgagac cagcctggcc 56640 aatatggtga aaccctgtct ctactaaaaa cacaaaagtt agccaggtgt ggtggtgggc 56700 acctgtaatc ccagctacct gggaggctga ggcagaagaa ttgcttgggc ccgggaggca 56760 gagtttgcag tgagcagaga tcgcgccatt gcactccagc ctgggtgaca gagtgagact 56820 ccatctcaaa aaacaaacaa acaaaaaaga agtgcagctt ttagatagaa ggaatagatt 56880 ctaggttcta cagcactgta gggtgactat aattaaagac aatgtattgt atattccaaa 56940 tagccggaag agcaaatttt gaatgttccc aacacaaaga aataatacat taaaaataat 57000 aaaagcaaca aaaaaagaaa aagtacagct ttgaagccag accaagttcc ggttgtacct 57060 gagacctttg attacctagc acaggttcat ctctgggttt tactttcctc atacacaaag 57120 taccagggac aaagtaggca catacgtgtt tatccctttt ctacccccca cgtcttttgt 57180 ctctgaccct catagacatt tatagctact ctgtttgctt taggtgggtg accagttgat 57240 attgcaaagt caggcaatag acccagcagt tgacttcagc aatccaactc catagtcctt 57300 acttcagaat atgttgtgaa ttgtatagtg tcttctttag gaatttcaat acaaaatttc 57360 tatacaggat cttttacctc acaagtggac tttagaacct aaccaacaag gtggtggatg 57420 tcctcttaga tttttttcct gtggacatta aatatatata catatatatg gattgtgtac 57480 atatattagg ttggtgcaaa agtaattggc aaaaaccgca attacttttg caacagccta 57540 atttaaatat gtatatataa ttttttcaat cagcaattct tgattgtttg attaagaatg 57600 tccaaatata caaatctctc tttttaaccc actcataatg tgtcactttg ttctaactta 57660 aagaactaac ccctaatgag gacatctaga ttgtctctac tataagtcat gctagcggga 57720 acatccttat gcccctgtgc agtgtattta aagaacaaat ttcaagaagt ggaattccaa 57780 tgcaagattg catctttgtt gaacagctgg ataatggtaa ggcattgcta gattttatga 57840 aaccaaaacc ctactgcctc tggtaagagt gagttttgtt ttgttttgtt ttgttttttt 57900 gatggagtct tgctctgtca cccaggctgg agtgcagtgg cacaacaatc ttggcttact 57960 gcaacctctg cctcccaggc tcaagggatt ctcctgcctc aggctcctga gaagctggga 58020 ctacagacgg gtgccaccac acccggctaa tttttgtgtt ttttagtaga gacagagttt 58080 catcatgttg gccaggccag tctcgaaccc ctgacctcag atgatccacc cgcctcggcc 58140 tcccaaagtt ctgggattac acttgtgagc caccacacct ggccaaggta agagtgattt 58200 ttaaaaacca aaaaattatc ccagagtctg ggaataaaat aaaagaggga ttaaaatcac 58260 tcttctaata ttctaaggct cttgaatgag gatgagccac ccctaatgga tattcattcc 58320 aatgaaagaa agactttata gaaagagaaa tctccagcct cacattttct ggatgggtca 58380 gtgggtgttg ctttgtaatc aaaaggctgc ctggccgttt gtgtctcttt agaccatatt 58440 gtaaaacttt tgcaatgaac agactagagt tgtatttgca tgtcaaagcc tcagttacta 58500 tcttgtttta accaaattct ctacgcataa aatatgtctt tatttactgt tcaaaaaatg 58560 gttttgaagg cactgctgac tacatcatcc acagcacttg atataaagtg cattataagc 58620 aaacttggaa ttcctgttgg ggacacacat tcccatcagg aacctggtct gcttcctctc 58680 tcctgctgtg actcatgacg tccctggccc ttcttgccag aaaacctagg gcaaatgtgc 58740 aggtcagtta cagcagacct gttccctaca atgttaccac attcgcattt ttctcattgc 58800 cttggctctg gttttctggt tttattttat taacttcatt attgactctt ttgtggtaaa 58860 acattttaaa gctttttttc tctgagaaag aggtagccta taaaaataat ctctttgttt 58920 ggcattgtta ataaatagat gaaacatgca tttcaaaata cccattgtat ggcaaagtgg 58980 taagagccca ggctgtagac ttagcttatg acttagactt gagagcgcac tcctgtgtga 59040 gtgagtctta gcctcacccc tcccagctat gctgtgcgcg agtcttttaa cctttctgag 59100 cctcagtttt ctcctctgta aagtcatctg gccgtatggt ttcttcaagg attaaatgag 59160 atgctcaata tattataaat gtgtaataga agaatactaa ggtggaaatc attgtaaagt 59220 gtagctcata tcacttggaa catgtaacca ctctcagttt ttgtcaggag tatattgtat 59280 tttctacatt tctggtactt tcatacagca taaggaattg caagacctgt tctgagtttg 59340 ggttgctcat ccccatgtca catggaggac ctctgttgag gtttctggtg ggagagtgtc 59400 tgaatggggg accccaaaca ctttgtgagc agagatcagc tgtgcctgag cagtgaggcc 59460 atgctaattc tccacgtggc tttaattttt tcatttacag tgcatacatt cgatgttaaa 59520 ttatccatga caatggtgga aagaaattaa gcataaataa atggccatct atcgatcttc 59580 ctgtcttgga tgtcaccacc ccacccacat ccacctgctt tttgtttccg tccttccttt 59640 tcccaagaga agagagagag agagagagag agagaacgct ggagcgagca gcgagggcag 59700 gggaactgca ggaacgcagt ggggggggga caggggattc cctgtgccct ggttgtggca 59760 cagctcagtc agggctcggt ccgtgctggg agggagctgg atcgagcggc ccggtgcgct 59820 gtgggttggc cgcacccatg cagggctcct gccccggagc tcgcggcgtg cgcagggtcc 59880 tcgtgctgct attaacgtat ttgcccattt gtaaagcacg attttaaggg atggtgagtt 59940 aaacaccgct ttttcgggga gggtgacggg gcgtgggagg gatgagactg gtgaaaaaag 60000 aactcccatg cttacttaga gatcaactct aaacccatgg ccatttcaga aactttagcg 60060 tattaaaaaa tgtgctgttt tgaatcaaag aagtacttgc ttccccttta ttttgggaac 60120 tgcagctcgc tagtttcaga aagaggtgtg gctgctcttt agaggcttca tacctcaagt 60180 aatgaaatga taaacaagtt gaagttccta gaccaattgg aagcctgcag gaaaaaacgc 60240 aggcctggac gcgtggcagc gatgccggag agggccgagt tcccagaaga gctcttgagg 60300 tttcttagta caattcctcc cccacgagat attgcctagt cacaccacct ctcccccttc 60360 cccaaactcc tgtcatctct ccttcctcta gacttaactc taagccctag gcaccagatt 60420 tggcagtgct tcagaattac acatcacatg gggagcagca tgctcccact gtgccccaga 60480 agagtttccc ggacagtgtc cagagaatct gttcggtgag aaccaacttc taatgaagtt 60540 tgtgagattt tattttttta ttatttatta ttattatttt tttgagacgg agtcttgctg 60600 tcgcccaggc tggagtgcag tggcgcgatc tcggctcact gcaccctccc cgggccgggt 60660 tcaagcgatt ctcctgcctc agcctcccga gtagctggga ctacaggcgt gtgccaccac 60720 gcccagctaa tttttgtata tttagtagag atggggtttc accatgttgg ccaggatggt 60780 ctccatctct tgacctcgtg atccgccttc cttggcttca caaagtgctg ggattacagg 60840 cctgagccac cgcgcccggc tgttttgttt ttaatgcata gatttgaccc aatactgtaa 60900 gacaagaact gtgtctgatt caaatgttca aaatcacctt tgcagtcccc agagtgcgtg 60960 tgtagtgctc agccgtcctg cgttaatgga atcactggat gacagagttc atgtttagat 61020 gtgcaccgtg tgttgttctg ccctggtcag gcaccagccc ccttcttgcc atggtggctt 61080 tcctccactg tcctagcatg gcttgcggag accgtcattt tgcttttacc tgcgctagta 61140 ctcctggttt cctgactcaa gtagcttact cagtagccct actggatttg atcatctgaa 61200 tgttttcata agtatcttct ctcccataag tgtgtttcct caattcattt ccagtcttga 61260 tgaaagccag gccatcttcc taggccccta cctatgttta gctggagcca ggttctgcag 61320 attctagctc ttcatcacct gcccttgaag tctcaaggcc ccccacccca ctccaccttg 61380 cacactgcag attggatgtg tcatttgtct tcagggtaaa aaatcaacca ctcagcttca 61440 catccagcat gtgcctccct ctctggccct gactcctgac cttccctacc tgctccttga 61500 ctgcagtgtt tagtgttgta gatagagctc attttctgaa gagattaggt tgatctagct 61560 ctctgaaggg gccatgttat cttgagctca tggtggttgc atatgaagtt tcttcttcct 61620 ggaatctctt tgctgacttt gcaaactggc tgccatcccg cccatttcaa ctcacagagc 61680 atttccttta ggaagctttc cctgaccacc tccttttcct cttgcctgag ttacatgtcc 61740 tttcttagat cctgtgggtc ctctgtcatc gagtctttac acatctttgc cacaagaata 61800 cgagcagagt tagagctgga ttttgtctgg gtgatggaaa attaatgctc aataaatatt 61860 tgttgagtga atcaatggac aggcaaacct atttgggaac agtattcact ttgagtttat 61920 taatctatat atgataaaga ataaaagtat attttttcta ctctttttta ttggagacat 61980 tttgatggct tgaagcagtt ctggaatggt aaaacaatgt cattactttt atgtttcaac 62040 aggaaatatg ggatgtataa aatcaaaagg gaaagacagc ttgagtgacg atggagtaga 62100 tttgaagact caaccagtac gtaatactga aagaactatt tatgtgagag atccaacgtc 62160 caataaacag caaaggccag taagtagata gtctcagggg agaattccca cagcaagatc 62220 aaagcatggc tacataattt aaacaccagt ctgtaatatg tgcatgcaaa aaaattccat 62280 tgattacttg gtcctcaaat aatttttgat atgctttgta actttatcct ttgaagaatg 62340 tataaatatt ttagggataa ctaggccact cattgtgcaa ttaaaagggc ctttggtcac 62400 attcttttgt gtgaagaaag ccatctttca tattactggt gcaaagaccc cactatatat 62460 atatacacac acatatatat gtgtgtgtgt atatatgtgt atatatgtat atatatgtgt 62520 atatatatat gtgtatatat atgtgtatat atatgtgtat atatatgtgt atatatatat 62580 gtgtatatat gtgtatatat atgtgtgtat atatatatat gtgtgtgtgt gtatatatat 62640 atatatacac acatacatac ataggcttgt gtgactcaag atagtagtga gaggctgggc 62700 gcggtggctc acgcttgtaa tcccagcact ttgggaggct gaggtgggca gatcactagg 62760 tcaggagctc gagaccagcc tggccaacat agtgaaaccc catctctact aaaaatacaa 62820 aaattagctg ggcacagtgg cgggcgcctg taatcccagc tactcaggag gctgaggcag 62880 gagaatcgct tgaacctggg aagcagaggt tgcagtgagc caagattgca ccactgccct 62940 ccagcctggg tgacagaaca agactctgtc tcaaaaaaaa aaaaaaaaaa agatgtagtg 63000 agattagctc agtggtttag aagcaaaagg aaatgtggga tgcaagtcag aaactaaaat 63060 aggtgctaat gtgtcttttg ttgtatcata ctttatcctg tcctgtcatt tcttcaatta 63120 attcaaaata gtacagatcc tgaagttgtc atctgttatt ttagtgaatt aaaatattaa 63180 ggaaaaacac ctctaattct gtcccctaac cttagagaaa tagctggact agaaatattt 63240 tatgagtgat gtgctatttg gtgtatttcg gaaatacttg gcaaagaaag aactaacatc 63300 acattttatg gaaaggaaga acagagcttt gaacaattat aacctgaaat ctacttcatt 63360 tccgagctta tatcctttgc atatatgtat tctctcactg tatacatgta taccacccat 63420 agcctgcttt ctatggaatt ctgcagcatt taagctggaa acagtttatt ccagattagc 63480 ccaaatccca ttattaagaa ttttcaggct gggcatggtg gttcatgcct gtactttggg 63540 aggtcacaag gtcaggagtt tgagaccagc ctggccaaca tggtgaaacc tcagctctac 63600 taaaagtaca aaaattagcc gggtgtggtg gtgcgtgcct gtagtcccag ctacttggga 63660 ggctgaggaa gaagaattgc ttgaacccag agggtggagg ttgcagtgag ccgagattgc 63720 gctactgcac tccagcctgg gtgacagagc gagactctgt ctcaaaaaaa aaaaaaaaaa 63780 aaggcatttt tatagtttct ctagtctgac atgtttttaa atgctcaggt gttttagaaa 63840 tatattccca ttatcaaacc tttctgcctg ccctcccctc aatatgtccc cattaccctg 63900 aaggtaggaa atatctgcca tgtatcaaag tcacatgtca tcattgagac aaagaaatca 63960 acatcggtct tcttaagaag tggagatagg ccaggcacgg tggctcatgc ctgtaatccc 64020 agcactttgg gaggccgagg caggtgcatc acctgaggtc aggagttcaa gaccagcctg 64080 gccaacatgg tgaaacccca tctctactaa aaatacaaaa attagctggg catggtggca 64140 catgcctgta atcccagcta cttgggaggc tgaggcagga gaattgtttg aaccaggacc 64200 cgggagggag aggttgcagt gagccgagat cacgccactg cactccagcc tgggttacag 64260 agcgagagtc tccaaaaaaa aaggaagtgg agataaagag tggatatatc atgctattaa 64320 gttatcatac atgatgtttc ttgataaatt aacattgtaa ttttatatat agaaaatata 64380 tgtacttaaa atgtatagga atattaatag atttaattgt gtgattataa atataaaatt 64440 taaaaaccta ttacaggcag tgaaagaaac attacataag tatgtacaga tatagaacca 64500 tatcatatat aaatatgatt aatagaaaat aaaataagag aaattagagt cacaaatagt 64560 tttcttatag acatcagagt tctcaaaaaa agatctgatt tttctcatac catatgctat 64620 agattttgta ggttttaaaa cacaagtttt ttcgttttgc acttatttat tcatttattt 64680 attttgaggt ggagatttgc tcttgttgcc caggctggag tgcaatggca ccatctcagc 64740 tcactgcaac ctcctcctcc tgagttcaag cgattctcct gcctcagcct cccgagtacc 64800 tgggattaca ggcatgcacc accatgcctg gctaattttt gtatttttag tagagatggg 64860 gttttgccat gttggccagg cttgtcttga actccttacc tcaggtgatt cacccacctc 64920 ggcctctcaa agtgttggga atacaggcgt gagccaccac acccagcctg ttttttgttt 64980 ttaaatgatg aataaagatg tcctttattc agaaaagtca aggagaatag tgtgcaaacc 65040 cacacaccgc tttttcctct tgttcaaaat aaaggggatt aaaaatcaag ttagaaagca 65100 gaagtagtaa acacgcttga agtctttcaa ttccctcctg tataccattt tttgcccctt 65160 ctgtggtcac agatgccctc cactcatgag ccagttagcc tggccttatt ccatggccat 65220 aaccaacact ctcagccctg gccagatatg acaaaatgca cgctatggat tgattaaaag 65280 gggaatttga tgagaaggtg aggtagggtt gatgcaaatt caacaacatt ctagaaaaag 65340 ccattttaag gaaaaatcta gagcaatagt atatgtgtgg catacatgtg tttcggtctt 65400 ataaaaagca tattaaaatg tttgtaagtt aagggctttt tgaaatttga aaaatcagct 65460 tgctgctttt aaaatgatgt aattagtttc tagtcttcta gttatttcct ctaaatcaca 65520 taaaatagat catatatcca aattatgcaa atctgaatga ctaaaaaatc aacataaaac 65580 ttcctgacat aaacatttga aggatagtat gcagccatgg gtttttctgg tactacaatg 65640 tagtaatttt ccctgtctca ctgaaatgga gattttatgg gctttcatca gaaatttaaa 65700 tttcagtaca aactgttttg gtcccattct gtgaagccac tttaatcaaa gagagacaga 65760 aaagttacat gacttgtggt ataggcctct gacagcatct atcttacaag aggcccagag 65820 gcctcacaca gcctcatgtg gcactgtgaa gaaaagaatt tgattttaaa ggtaattgag 65880 gtggtcttct gtgccaccaa atccttccca ataactcacc cccccactga aataacaggg 65940 gatgccatct gtccctgtga tggagtcagg gtcagcccaa gaaaacctgg atgggatggg 66000 acttgctctc agcctccagg gacagagccc tgaccatgca attttataca attggggaag 66060 cctcagatgg gcagtcccag gctgggacgg caactccacg aaatcaccag ggtcccacct 66120 cttccgtctc catcctgctg ccgctggtgt ttgctttcta tgtgaagact ccagccttca 66180 cttgtttcta gggagagaga aagaggcaag ggaaaagggg agctgacagc aaagccctgc 66240 acaaccgatc tgcggaccaa aactccctct gccctctgcc cggggctaga gagtttggaa 66300 gcacactcat tgagctgggc aaactgccac cccaaataat attagggctc tgtcaccaaa 66360 gaagaggagg agctaggatg aggtgagcac ctggcacctg cccagaacct cgctcccttc 66420 ctgccaccca cagcaagtga taaagagccc tgtcactggc caagcagggc aggatgcacc 66480 tctacaggtt tttccctctg tgctcctgtt ctttctgact taataaatga gcccatccta 66540 acatctgcta ctgttacaaa aatcatatat acaacacgaa tgtgagtaag aaaagctaaa 66600 cagaattttt ttttctaaca aatattctct cgtaggttcc agaatctcag cttttacctg 66660 gacagaggtt tcaaactaaa ggtatgtttt catagcaaca tagttaaaat tttttttctt 66720 tactattaga gcttctataa agtgattgtc ctaaatgttt ttattttttt ttattgtggg 66780 acatatataa cataaaaatt taccctctta actattttta agtatacatt tcagcagcat 66840 taggtacatt cacattgttg tacaaccaat accgccctcc atctccagaa tgcatcttct 66900 caaactccat acccattaaa caataagtcc ccattgcctc ctcccccagc cgctggcaac 66960 ctccgctctt tctgtcttta tgaatttcac tactctaggt acctcctaga agtggaatca 67020 tacagtaatt gtccttttgt gtttggatta tttcacttag cctgatgtcc tcaaggttca 67080 tccatgctgt agaaagtgtt agaatttatt tccttctaat agtgaataat atttccttgt 67140 aagtatatgc cctggccggg tgcagtggct cacacctgta atcccagcac tttgggaggc 67200 caagttaggt agatcacctg tggtcaggag ttcgagacca gcctggtcaa catggtgaaa 67260 ccccgtctct actaaaaaca caaaaaatta gccaggcgtg gtggtgggcg cctgtaatcc 67320 cagctactgg ggaggctgag gcaggagaat agcttgaacc caggaggtgg aggttgcagt 67380 gagccgagat tgcactattg cactccagtc tgggcgacaa gagcgagact ccgtctcaaa 67440 agagaaaaac caaaatgcta catgatgttt atccattcct ccatcaatag atgtttgcat 67500 tatttccaca tcttggctat tttgaataat cctgctgtga acatgggtgt ataatttctt 67560 aaatatagag ttgtatttat agttttagtt ttaagtgatt tgcaagaaca aatactggac 67620 acagtgtata cagcaaggta ctctctgtgg gccgtgcaga ccctgagccc actaggcagg 67680 aagcacatgt ccttcttcca gttgccccct cttagtgctt cctctcatcc tttgtgcccc 67740 atgaggtttg ttaaaacgct tctgctgatg gattcttaca ggtgttctct tgtgttcatc 67800 tttagatcca gaggaacaag gagacattgt ggtagccttg tacccctatg atggcatcca 67860 cccggacgac ttgtctttca agaaaggaga gaagatgaaa gtcctggagg agtaagtgct 67920 ctcaagcacg ccacggctgc tcgtttcctc aggccactga gtcctgcagg ctgtcccctt 67980 gtcttgcttc tggtgctaca gccatagccc ggcccctttc ttgtaatggg tatgaggcct 68040 ccttgctacc cacagggagt gggcagtgga aggaatagag ccaaagggat tttcctttta 68100 agtcggtctg tgagcacact tcagggggtt tccctttgaa gacagacagt ggtttttctt 68160 taaaacaatt tttttttttg agatgggatc tctctctgtc atccaggcta gaatgcagtg 68220 gcatgatcat agctcactgc agccttgaac tcctaggcta aagcaatcct ctcacctcag 68280 cctcctgaga agctaggact acaggcatgt gccaccaggc ctggctaatt tttaaaattt 68340 ttgtagagat gggatcttgt tatgttgccc aggctggtct tgaactcctg ctgtcaagca 68400 attctcctgc cttggcctcc caaagtgctg ggattacagg tgtgagccac cacacccagc 68460 ctggtttctt tctttatcca ctcttgccac cttaagaaat ttgggtctgt gtggcccatg 68520 catgatactt gaaatgtcac ttttcttttg ttatattact catgtttaga ctgggttcat 68580 gggcccagcc tagcttgagt tctaagggta ctgagctaca gcagctgtgt tgggaaattc 68640 tcaactcagc agctgccatg cttttgtgag gacgcctgag tgtcgtcatc tcctcaaccc 68700 cctcttgctg actcagacat gtggcagtgt cagaccatag gcatgcagga cagtgctcag 68760 aataagaaac tccagttgct ttaattctag cttgcttttc ttactaatct tgcattaaat 68820 gtcactgtga cctgccaaat agggtttgag ggggagactc ccttattaag gacaaggtgt 68880 tccgtggttg agagcaatgt tgcatatggg ttgaacaggg acttaagcct gatcctggcc 68940 ctgccacttg atagctgtat gaccttgaca agacccttaa actttatacc ttggtttctt 69000 tacttataaa atgggaatga cagtacctag atcatggggt tgatgtgagc atgatgcatg 69060 tgtttaaaca tgacataagc aaagaggatg cagagcttag tattagttct agttgccttc 69120 atgccttaca gacaaggatc ctgtctgtgt gtggaattta tagaggaatg cagttaaggc 69180 tcaaagggac ccattccttc ccccattacc agcttacctg cttgcttctt ccagtgctca 69240 tccctgcctc ctccctggct ccatgcctgc ctttctgctg aggactcgag catggtgctg 69300 aagctcactt gcttggaatt gtcttatggt tttcttcttt tcatagtgtc catctctatg 69360 ataactagat gtttgaacaa aggagtttat aatgcatgaa ctgtggacca gtattccctt 69420 gactctcatt tctataagga tttgaaagca tttcttagct atcctggggc aagttacaaa 69480 ccttttgttt ctgtgagatg ggagccattt gtaccaactc ttctttgtgc acccctgatc 69540 gcagtgatgc gtgctttagt tgtaaggctg ttttcctttg cttctgtctc taaacatatt 69600 ttaattccat cacggagagt gaattttccc actggattct ggggttccag agatgttctc 69660 cacccgcctt caccatccta aacaaacatc ttgagacaat tgctattgta gctgttgagt 69720 cttggatata aacacttttt tccttttatt tttagttgac atggaataat tatatgcagt 69780 catgggatac agagcgatat tttgatacat gtatgcagtg tgtacggatc aagtcagcgt 69840 aattagcata tccatcatct ggaacattta ttctttcttt gtgttgtgaa cattcaaaac 69900 cctcactcct ggcttctttt ctttgtctct ctctctctct ttttaatagc tttattgaga 69960 attcacaata ccatacaatc catctactta aagtgtacaa ttcagtgatt tttttagtat 70020 agtcacagaa ttgtgcaatc atcaccacaa tccattttag aacattttaa ataccccaaa 70080 aggaaaccct gcacccctta gctgtcacct caactctccc attctctgca gccctaggaa 70140 accacgaatc tactttttat ctctgaagac tgacctattc tggatatttc acataaatgg 70200 aatcatacaa tatgtggtcc tttttgactg ccttctttta tttagcataa tgttttcaaa 70260 gttcatccct gttgtagcat ctctcagcac tccattcctt tcactgctga gtaatactcc 70320 actggatgga tattccagat tttgtccatt catcagttga taggcatttt ggttgtttct 70380 actttttgct tttacaaata aggatgcttt gaacattcat gtacaagttt ttgtgtggac 70440 attatggttt catctttctt gggtatatgt caaggagtat agttgctggg tcctgtggta 70500 agtctatgtt ttctttattt ttaatttttt aattgatatg taatatctgt acataaatac 70560 atatttatgg gatatctgtg atattttgat acatgcatgg agtatgtaat cttttagctt 70620 ctttttgatg tgtatttcta ttctaggcat ggagaatggt ggaaagcaaa gtccctttta 70680 acaaaaaaag aaggcttcat ccccagcaac tatgtggcca aactcaacac cttagaaaca 70740 gaagagtgag tcctcatgtg ttgtcatctt ggtggcttta tttgccacat tggatttctt 70800 gttaatattc ttcacctttt tcttgccgtg gaacataata tgcaggaaat gttgaaatgt 70860 cttcacaggt ggtttttcaa ggatataacc aggaaggacg cagaaaggca gcttttggca 70920 ccaggaaata gcgctggagc tttccttatt agagaaagtg aaacattaaa aggtaggaaa 70980 ttgttcaaag cctcttttaa aacactattt aggaaattat ttttagaaac tattctagag 71040 ctactcaagg ggaaaaaagg gcatatagta tgctctggta gtaaaagttt tatggtttga 71100 taacaaataa caaacctcag tgattagttg tgctactaaa agtaatatag ttgagtgtgg 71160 tggctcacac ctgtaatcct aacactttgg gaggctgagg cgagaggatc acttgagtcc 71220 agcagttaga gaccagcctg ggcaacacag caagacccca tctctacaag aaatacaaaa 71280 cttagccagg cctggcagca catgcctata gtcccagcta ctctggaggc tgaggtagga 71340 agatcacctg aacccaggga agggaggctg cagtgagccg tgatcacgcc actgcactct 71400 aactagcctg agtgacagag tgaggcactg tctcaaaaaa aaaagagaaa agaaaagaaa 71460 agtactgtag aaagcacaca tgattgtggc cagttcttac caggctttgt ttgctgagcc 71520 ttttgcatta ttatttgaat aaatcctgaa gttttaagac aaagaaaatt aggctgggcg 71580 tggtggctca ggcctgtaat cccaatgctt tgggaggccg agactgagaa tcacttgaac 71640 ccagcagttt gataccagcc tgggcaacat agcaagagcc tgtttctata agaaattaaa 71700 aaattagcca gctgtggtgg tgcatgatcg tagtctcagc tacttgagag gttggggtag 71760 aaagatcgtt tgagcccaag aggtggaggc tgcagttagc tatgattgtg ccactctact 71820 ctagcctggg tgacagagca acaacctatt tcaaaaaaaa aaaaaagaaa atcaaagtaa 71880 cttaaaaaaa tttaaatgta gctaaataat aattttaaaa aaattatcat gaagaaagaa 71940 aatggtatgt tggcaagcta cacagcaaac aaaatgccag cttcatttgt caagtagaat 72000 ttttatagga cttttaaaat tatgcatttt atacaaattt cataaatata tgtattttgc 72060 atatttgtat cacaaaatgt gtactgcagt tgttgtataa tgcagatctt atttgtgaga 72120 tataaacatt tacttacact tttcccccca taggaagctt ctctctgtct gtcagagact 72180 ttgaccctgt gcatggtgat gttattaagc actacaaaat tagaagtctg gataatgggg 72240 gctattacat ctctccacga atcacttttc cctgtatcag cgacatgatt aaacattacc 72300 aaagtaagta aaaactgaag gttcaacaag acaagatata tttgttatga tatgtataag 72360 acgtcaaacg ctatttttat attaaaactt tttatgcatc gtatttctct tagatacagt 72420 tgcaggtcat attctataag tggttctaaa ttaatctata gttaggccag gcacagtggc 72480 tcacgcctgt aatcccagca ctttgggagg ccaaggcagg tggatcactt gaggtcagga 72540 gttcgagacc agcctggcca acctggtgat accccatctc tactagaaaa aaaaaaaatt 72600 agccaggcat agtggtgcgt gcctgtagtc ccagctactc gggaggctga ggcaggagaa 72660 tcacttgaac acaggaggcg gagattgcag tgagctgaga tcgcgccact gcactccagc 72720 ctgggtgaca gagcaagact ctgtctcaaa aaacaaatac taaaataaaa gcaattaatt 72780 aatctacagt taaatacaca aagtaagatt tgatccttgt gaataattct cccagtcctt 72840 cccacctagt acatgctgtt tgacattcag tgttccacaa ttaccaagag aaaaatatat 72900 attgtctttg catatatttt tacaatgcat ctgaatatct ggaataggaa tgcagatttg 72960 cagatctgtg tttgtgtgtg tgtgtgtaaa agtaatgtat attcttggta aagtcaaacg 73020 gatataacac taccactgaa atatttagaa gtggcaggtc aatgtccctg tctccagtgc 73080 cactttgcag tcctgagaag cctgggcctg agactctggg tccctttcct gtgtaattgg 73140 agtcagttga gtggttgttg ccccggctcc tttctatgac ctgctcgaag gggatgcaca 73200 ttataggttt gcttgagtcc caaaacacgg agagagcaac gtgcttccga ttttgtagat 73260 tcttgccttc ctccgccctc ccattcctgt gtgcatccgg cacatgctga gggcttgtgg 73320 tactctggct gtgttctggg gcctggggtc cagtggtgac atgaccgagt ccccactatg 73380 gtgccctgtg aagcttaatg tgggattagt aatctgaaac cacattttat taagtgtgac 73440 aatctggcag cctgtggttg tctgttggct ttgttgtttt tgttcatgta tgttagcagt 73500 gctgaagaat acaatcaagt atgttttaaa tggtttttct tatataaatt tcaggccggg 73560 cttggtggct cacacctgta atccagcatt ttgggaggcc gaggcgggtg gatcacttga 73620 ggtcaggagt ttgtgaccag cctggccaac gtagtaaaat tctgtctcta ctaaaaaata 73680 taaaaactag ctgggcatag tggtgggcac ctgtaatccc agttactttg gaggctgagg 73740 cagaagaatt tcttgaaccc aggaggcgga ggttgcagtg agccaagatc gcccattgca 73800 ctccagcctg ggcaatagga gtgaaacttc atctcaaaaa aaagaaaaac aaaaaaaacc 73860 cacaaatttc aaaagtcaca attatgtcaa ggatgcattt tagttcacag actgcggcag 73920 gttggacact ataaggctag tgttcaactt ttctttatag acacaggtaa agtacaaagt 73980 attgcatttc ttaaccttca tttttccctt tcaaattaga gcaggcagat ggcttgtgca 74040 gaagattgga gaaggcttgt attagtccca agccacagaa gccatgggat aaagatgcct 74100 gggagatccc ccgggagtcc atcaagttgg tgaaaaggct tggcgctggg cagtttgggg 74160 aagtctggat gggtaagtgt gcggctcggg gatctatgtc cttctagaga tggtgacagg 74220 agaagtaaag gctcaagcca atttcgatca gcttctgagc cagacactaa attatgtcag 74280 aagcatcatt tattttgttt tcctctgtcc attggggctg agaactggcc tgcaaaatct 74340 atttacttca gctcttgctc tttcttgcga cttagtaatt ctcttaatgt ttgtaaggag 74400 gggagtaatg ggtatttatc ttgatcatct gcctatttct tcatgattcc ctcatcgcca 74460 gattctctgg atgcacggct caagtgcaag aaatttgctt ccatctctgg gaaaggttat 74520 cttagggctg gaacccattg gcttaataga aagcctcaat gtattacaat ttgagggtca 74580 ccaagaaagt ttctaaggtt ctcaaagtca cgtcatgaag aaatcatttc ttaacattaa 74640 gtattgcctt ctcaggctgg caagaagtgc agcaagatta tagcagtggc tttttccagg 74700 ggattctttt catctaccta ctttaaaaaa aagtttttat agtgagctga gcacagtggc 74760 tcatacctgt aatcccagca ctttgggagg ctgaagcagg aagattgctt gatcctagga 74820 ggctgagaac agcctgagca acatagcaga ccctgtctct acaaataaag aaattagcca 74880 ggtgccatgg tatgtgcctg tagttccagc tacttgggag gctgaggtgg gaggatcact 74940 taagccaagg aggtcgaggc tgcagtgggc cgagatggca ctcctgcact ccagcctggg 75000 tgacacagtg agaccctgcc tcaaaataaa taaataaata aataaataaa taaataaata 75060 aaagttttca tagtgaatgt gaacttcttt ggtgataaga gttttttaga acaaaaatgc 75120 taaagcataa cattctttta atggttctaa tggaatgtgc ggttatttct ggaaagagta 75180 acatgttagg tcacacacat ctgactgggt cactttttct gtgtcagctt tgttgagtga 75240 aagcaaatgt gatttctaaa tggaaggggc agatggcttt taaacactct ccagccccgg 75300 cagaacagaa gctgcagcca cgtggacacg tcacctctgc atccaggttt tccctctaca 75360 gtcttggccc ctgggatcat agccttgctc actttctcct gttggcccct cttgagcaga 75420 agtgactttt aaacacggca catactgagc cagcctatca ttaattaatt cttactgcac 75480 tgtaagtctt tctgcacata tttgcagaat tcaggtaaac tgtaattaca tgacttcaca 75540 ttctccgtgt ggatcggcat gtgtcagaac tggctggcag tgcaaatcag gtcctcagtt 75600 tctgttccac tcagcagatt catgggtgtg agtgctcact ctgaatgttg tctcttccca 75660 tgcacactct gttgtcttcc tcctcatttc tctgtgtgct ctttttttaa ttaacatgaa 75720 attcacctga cataaattaa tcatttaaaa ggaacaatcc actggcattt agtacattca 75780 caatattgtg tagccaccac ctccatctac tttcaaaatg tttttatcat cccgaaagga 75840 aacaatgtac ccaataaaca atcactcttc attcgcccca ccctcagccc ctggcaacca 75900 ccattctttc tgtctctatg aatttaacca ctctaggtac ctcatataag tggaatcatt 75960 tatttgccct tttgtgtctg gcttatttca cctagcataa tgttttcaag gttcatccat 76020 gttgtagaat gtattagaat tttcttgttt tatggctgag taatattcca ttgcatgact 76080 ataacagagt ttgtttatct acttatccat tggtggacct ttcagttgtt tttacctttt 76140 gactgttatg aataatgctg tatgaatgtt cacatacaaa ttattatgtg gacacatttt 76200 catttctctt gtgtataaac ctaggagttc agttgctggg gcatgtgata agcctctgtt 76260 gaactttttc aagaaccaca aaactattat atgctcatta aaaaaagaat gacttggctt 76320 cttttttcct cctttgatgt ttatatttat ttttttccaa atctacagaa tggggcagga 76380 atagtataat gaatattgta tacccttcac atagattcac cagttgttaa tattgtccta 76440 attttcttgt tcttttatat acgtacacat acatacatgt tattattgcc gttgaccacc 76500 tgagattaag tgcagacgtg acttgctgag ttttgtgaag agtgtttaag cacctaagca 76560 gtactgtgtt ctcagggcac ctgtcaggag gcatagtatt agccggtcct attcttaatg 76620 atgttctatt tgattttatc tacagtaatc caccatcact tttatttaaa gtgatccaaa 76680 agtttaaatg gatcatttaa atttagtttc tccgtggcaa ctttttactc ccttttgtag 76740 taaataaata ctctgtggga agtttaagat tatgtaaata gaactttctc caaatggttt 76800 cagcacgatc tgtgaattct cttccctctt agaagccgtc acttctctat aaagctccag 76860 tcctttctgt cctcctccct tgctccttga acatgtctat tccaacccca ctggctcacg 76920 tcaagatcca gggacttctg cgttctcttc ccggcttctc cgtctgttca ctgagagtat 76980 tggcaggaaa accaggatcg caatcacact taattgtgct cttagtccat ctgagtactt 77040 actgtgactt tgtgtgggga gaaggaggag aagacaggag gaagggagaa aagagtgtac 77100 aggctctacg ggccctgctc taagtgtgtt tgcattgaca ttctcactta ctcattgctg 77160 tagcactgtg aatgagaggc attactgtga tcattcgata aacaacatca ctgagaatca 77220 gataagcaac ttactcaagg tcattcaagg cagtgagaga gccaggctgc tctggcatct 77280 gggaaccctg gactcaatta tttgctacac tatttctaag ctaatttgac ttccctagcc 77340 tcagtttcca catcagtgaa gtggacaaac tccaatcttc agttgttcaa aggaagaatg 77400 agattatgca cctgggatgt ttcccagagt ctgactccgt gtgccctatt tttattattg 77460 tcactttttt gttttttatt ctagttattg gaagctatat tttggtgtat tttccccaat 77520 tttaatcata aaacagagcc ataaataatc caattagact ttcctatgga tatttgctgg 77580 caaaggaatt aacgtgtctg tcatgaaaag aaatgtagag ggaggttaat caggatgtac 77640 tggttcatcc taaatcagta gccctgcata taaagtcatg gcttggaatc ttgttctagc 77700 ctctcctgtt cagctgtgaa gccaggataa agcatcaaat tgcatgctat ttgctcctga 77760 gagacaagta aagtgaacaa agtaattcaa atccaactgc ttgagtgaat tatttcttag 77820 taacactgtt tttaaagatg cagttgttgg cagggcacgg tggctcacac ctgtaatcct 77880 ggcacttcgg gaggccgagg caggtagatc acttgagctc agaagttcaa gactagtctg 77940 gacaacatgg tgaaaccctg tctctatcaa aaatacaaaa aaaaattagt tgagcatggt 78000 ggtgttgcac ctgtgtttcc atctacttag gaggttgagg tgggaggatc gcttgagcct 78060 aggaggcaga ggttgcagtg agctgagatt gcgccgctgt caccaaactg ggtgacagag 78120 tgagacccca tctcaaaaaa taaataaata aatatgcagt tgctgccagc ctggatgcct 78180 ggcatcaaaa gtgctgctgt cagctgtggt gtcagtgcgt cctgcagggg gtgcctggcg 78240 aggttgggag caggaagtca ggagctaggc agcctggagc acacacctca gcagacctgc 78300 ttacaccccc tgttctgtcg taaggtgtaa gtctgcacta aaattgtaca cctggagctt 78360 aagaacattg gtcctttctg ggattgggaa aaccgccttg cttctaattc cagatacact 78420 gaatcctcca atttctcttc tttcctgcac acagcttaat tttagagaac ttttgcttaa 78480 catatattca ggtggtgcct aggagaaaca agtttagaag agaagagaat ggagtgttgg 78540 aaagtatctg attgttttat acaaattttt actttttatt tagactgaaa caggataaaa 78600 atcttgagaa aatacatcac ttgaatagat ttgctcattc cgtttttaaa aattgtggtt 78660 aaatacacgt gacataaaat ttgtgtttta gcgatgttta ggtgtacagt tcagtagtgt 78720 taaatgcatc tacactgtta tgcaaccaat ctccagactc tcttttcatc tgataaaact 78780 gagagactgt gtactcttta acaccaactc cctgatcccc tctctggcaa ccaccatgct 78840 actttctgtc tctatgaatt tgactacctt aggtacctca aataattaga atcatacagt 78900 atttgtcttt ttgtctctgg cttacttcac ttagcatgat gtctccaagg tttatctatg 78960 tcgtagcatg tgtcagaatt tctttgcttt ttaaggctta atgatattcc tttatatgca 79020 tacataacct tttgtttatt catctattga tggacaatta ggttgtttct accttttggc 79080 tattgtgaat ttgccactgt gaacatgggt gcacagatac ctctctgaga ccttattttc 79140 cattcctttg agtataaatc cagaagtgga atggctggat cctgtaattc ttctatctct 79200 aaaatttgga ggaactgccg tactgttttc tacttcggct gcaccatttt acattcccat 79260 tgaccgtgtg taagtgttcc ctttctccac agcctcacca acagttgtta ttttctgttt 79320 tggggatttt ttttgttgtt ggctggttgg cttttgtgat agttgtcatt ttaatagatg 79380 tgagatggta tcttactgtg gttttgattt gtgttttcct aataattagt gaccaagcat 79440 cttttcatgt ccttcctggt catttctaca tcttctttgg agaaacgtat gttcaagtcc 79500 ctttctcact ttttaaattg tgttctttac ttgatttact aataacgttt taaatgacag 79560 aggcagtaga gcctcatcta aaatggggtt taatggaacc tatctcagag ggattacata 79620 acaattgaaa gaaattgtgc aggtaagttc aattgacagc attcaaagca ctgttattaa 79680 ataatatctt tagtaagaaa atatgtcaca ttagtgcaaa ggctatacag cagaggaaag 79740 aaattgccca gggtttccca ctaaatagaa gttgtttgta tttttgcttt ttaatttttt 79800 ttattttgag ataattgtgg atttacatgc cattgtgaga aataatacaa aaaggataac 79860 atatgtccac gcaaaaacct gtacatgagt gttcatagta gcattatttg taatagccaa 79920 aaagtacaaa caactgaaat gtccatcaga tgatgaatgg gtcaataaaa tgtggtgtat 79980 tcatacaatg gagtatttgg caataaaaaa aaaaaatgac ctggcatact tcaacatgga 80040 tgccatgctg ttttatggat gacttataat aacactatgt taagtgaaag aaatcaggcc 80100 caaaggagca catattatac tgttccattt atatgaaatg tccagaatag gcaaatctag 80160 agttagaaag tagatgactg gttgcctagg gctggggggc ctgggagtat ggtaggagtg 80220 actgctaatg agcatgggat ttctttttgg agtcatgaca acattctaaa gctaattgtg 80280 gtgatgattg tacaattctg aatatgcaaa taactgatga actatatact ttaaatgggt 80340 aaatgacatg gtatatgaat tatatttcaa taaagctggc aaatatataa aagaaatgat 80400 acagagagat cccatgtacc atttacccag tttcctccag tggtaacatc ttgtaaaact 80460 atagtacaac atcactacca ggatattggc attgatcacc gttcattttt taattgtgct 80520 tttcttccag tcttatattg aatggaggaa ggaaggaaaa gaagggaagg ggaggaaaag 80580 aaaatagaag agaaaaaaat agaaaatttt gacttgggat cttttgcttg tagggactga 80640 gtttgcctgt cagtcagcga gctccttctt cactcctgaa ataatttaaa tatgttgaat 80700 acacatagca gaggaatatt gggaatacaa ccaaaagagt tgtgattggt gattttatgt 80760 tacaaataga ctgaaggata ctccctctcc caattttgag ctgctagaat ttagttttct 80820 cttacccttt ttagtttctc aaaggataag caggccagct tttctcattg atagaaaaaa 80880 tacaattaaa attctatcac tgttaaccca gtaagttaat atttttgtta aacataagga 80940 attgttcatg gacaacccat ttcattttat ggtctgcatt tttttggctt gaaatgcagt 81000 gaacaaatac taggaagtga cctgttcttt gggggaaggg gctgggtggg gataaaagaa 81060 agaggtgtct ctgcttcaag ctgtttcctc ttgtttgtgt gatccttgtg acatctgact 81120 tgggtgacat gcttcctctg tggattgtcc tattcccagg gaatcaactg ggcagtgagg 81180 ctaaggacga tgtttcctct gactgcttgg tctatgaaga gaccctgagg aaggaaggaa 81240 acttatttta cattgaattt tgcttgataa attctcattt gagccaactg ccttgagatt 81300 aatcaccaac ccacttccaa aatcaactgc atgcattttt taaaaaccac tctccctttt 81360 gtggtacgtg ggcacttttt agcaagccag tcacagccgg aattagagtg ctctcaaggt 81420 gccacatcag ctttctttaa ctgtggcaaa gtgtcactcc acaagacgct ttttactagc 81480 tcaaaaagtt ttttttaaca taatttttca tctgtattga caacccaaat ctccatgact 81540 aggttaattt gaaccttcaa actaccagag agtatcttag aaacctatga tttgatcctt 81600 agcactgaat aaaaatcatg cctttaacag agggatgaaa accaccctat tgtttcaata 81660 tcacagccct aagagatcat ctgggagctg ccgccattct tgggccatgt ttgacacagc 81720 tgctttatct accactcacc tcaaactcct tatcagtatt taaaatatat gcagctgcaa 81780 tatttcctga tgacttcccc cctaaccttg gaaagcgttt tttttccttc gtcctttact 81840 catacttttc tatttataag tctccatgag cttcattgtt tttatgatgg caaaagggaa 81900 atggttttgt ttctttaact tttattgcta tgtaatgtaa caagcagaca gaaaatgcaa 81960 acacaaatat ctaatttcac aaataattac aaagcaaaaa ctggtgtgtc gacctctgag 82020 aggaaacttg ctagccccag aagcccccac cgtccaccca tcccctccca cccacaccct 82080 acctgtcccc cagagacaac agctattccg accttcctga tggttttctg acttcttctt 82140 aattttgcca cttttgtata tggggatgta tgcatccccc caaaatatag ctcagttttg 82200 ctgtttttgt actttgtatg aacgaattat accaaatgtg ctcttttacg tcttgcctct 82260 tttactcaac gggttggtga gaggcatcca tgcttttggg tgtggctaca gttcattcat 82320 cttcattcca tgtggtgttg gtaagataca tgtggctttt gggtatggct acaattcatt 82380 catcttcatt ccatatggtg ttggtgaaat gcatccatgc ttttgggtgt ggctacggtt 82440 cattcatctt catcctatgt tgtgttggtg agatgcatcc atgcttttgg gtgtggctat 82500 tgtttattca tcttcatgcc atatggtgtt ggtgagatgc atctgtgctt ttgcgtgtgg 82560 ctacaattca ttcatcttca gtccctatga tgttggtgag atgcatccgt gcttttgggt 82620 gtgactacag ttcattcatc ttcatctcat gtcgtgtttg tgagatgcac tcgtgcttct 82680 gggtgtggct atggttcatt cgtcttcatc ccatgtcgtg ttggtgagat gcatctgtgg 82740 ctacggttca ttcatcttca ttccatatgg tattggtgag atgcattcat gcttttgggt 82800 gtggctatgg tttattcatc ttcatgccat attgtgctgt gctgcatgtg ttttcaagat 82860 atacgatcat ttatccattt atttcaccat ttactgatga aattggagtt catgttagtc 82920 cattttgctt tgctaaagga atacccgaga ctgggtaact tataaagaaa atgtttattt 82980 gctttacggt tcttcagatt ttataagaag catggcacct gtctctgctt ctggtgaagc 83040 ctcaggaagc ttccattcaa aaaggaaggc aaaagggagt gagcatgtca cacagtgaga 83100 gcaagagagt gaccagaaga ggtgccatgc ttttagacaa ccagctctct tgtgaactaa 83160 tagagcgaga actcactctt taccacgggg atggccccaa gccattcatg agggattcat 83220 tcccatgacc caaatacctc cctctagtcc ccacctccaa cactggggat caaatttcaa 83280 catgagattt ggagaggaca aacatccaaa ctatatcaga gtttttccca gtttgggctg 83340 ctatgaacaa tgcgctgcac atttttgtgc ctcatttttg tgctgatgca agcatgcatg 83400 agctctaggg tgagtgggag tggatttgct ggatcgtaag gtgtatgaat cttcagctct 83460 tctaagttat tgccaactta ttttgcaaag tgctggtccc agcttaagat tctcaccagc 83520 aatatgccag tccccacgtc ccctttcctg actagcagag ctgtacttag agagatgtgg 83580 gccccaaggc agcacaggca gtgggtggtt atccggaagg aagtgtgcac tcagcatcct 83640 tcatggacac cttggatgtt gtcacagaag ctctgcaatt gaatttcagt gatgctcagc 83700 aaagaacaca gaatgaggcc tagggcagct gctccagagt ccctcccaag gggcaggtgc 83760 tcatcagcac ttgatattac cagactttaa aaatttttgc tgagctcggc agtggtttct 83820 catgacttta tttgcatttc tctggttgct aataagattg agtacttttc acgtgtttat 83880 tactcatatg aatttcttct tttgaaatgc ccttccaagt ctttgcctat ttcttctgat 83940 ttttcttatt gatttgtaag aattctttct atatcctgga tgcaagttcc ttgcagttat 84000 atgtatcata tagtttatgt attttcatct attttatatc atgtattttc ctgctgtgat 84060 ttgctatgga tatgctcatg taacttaggg ttagagttag ggctggggtt aaggttaggg 84120 tttataaacg ttaaaaaatt tataataaaa cctttttgat ttaaatgtaa tattaaaagg 84180 cttttgttgg tggaatgtac tttacaataa ctcttaagat ctacagaaaa ggccatattg 84240 cttgtaatta tgcatttaga tgtcagaaca atttaatata ttcataattc cattatttta 84300 ggtaggtggt agctttttaa aaggacctag gatggttttt ttttgtcagc tttatgttac 84360 tatcttctcc atatgttcta acacttatct tgtactgcat ttttcttttt cttttctttt 84420 tttgttttgt tttagagaag ggggtctcac tatattgccc aggttagtct tgaactcctg 84480 ggctcaagcg atcctcctgc ctctcaaagt gctgggatta caggcatgaa ccaccttgtc 84540 tagcctcatt tttctataga gcactgcaag ctcctaagta ttaaccaaag tggaatacaa 84600 aataaaacat tttaatagag gaatcagtct taatgaccaa aagaaacatc attggatagg 84660 ttgactgcta gctataaata aactttttat tatttgtttg aaggcttgga aatagatgta 84720 taatacattt ctttattatt taaaaaaatc attttttaaa aagtacatac ttggctgggc 84780 acagtggctc atgcctacaa tcccagcact ttggaagacc aaggtgagca gatcagctga 84840 ggtcaggagt tcaagaccag cctggccaac atggcaaaac cctgtctctc ctggaaaaaa 84900 gaaagagaag agaagagaaa agaaaagagt acatactcat tgacaaatcc aatcagaata 84960 gaaaagaaca agagaaagta gaagtcactc caaattctac cagccaggga taatcactgt 85020 tgttttactc agcaggcttc cagtcatctt tctatgctat tcacatacag atactcttgc 85080 accctaaaaa ggggaccgtc cactccacgt cacctttcct taggtggata gggcaggtgc 85140 tatccagctt ttgcgcacca ggcagcagga actgcaggaa gatttgcagt gacaccagca 85200 gctattactc ccttctcccc attttttttt taacatttcc aagagaaaga tggaagcaga 85260 agagaggaca ggaaggaaga gtatgattat taatatttct gctttgccaa attactgaga 85320 aaaggctttc ccaagagaaa gtcaggatta aagtgctcaa tcccagtccc agaagggtgg 85380 tgcctcgggg gaactatact aaggagtcag tattgcccag agcgtgttcc atgcggtgta 85440 agaggctact tgaacaagtg ttctgaggtc aagaaattgt gggaaacgct ggggtgaaca 85500 aatgcaggct tttcccctga aggcctccca gggcacctgc tgcatctcct gggtggggga 85560 ggagtggagg gagtggctcc ctgtcctttt agtgggggat cctttttcac taacagtcac 85620 ccaagtccag ttgtctgcaa attttgggaa gtgcttgttt gactctagca tattgtactt 85680 taaagttagt atatataagt aatttttata aagaacacct tttttaaaga aaatgtggta 85740 aatagttaaa gatatggtga acaaaattaa aatcgctcgt aatcacacca ttggaaataa 85800 ccagcatttg atatattttg gtgtcttttc ttccagactg ttgtttatat gtgtgtgtct 85860 gtgtatctat aaaatatgtc tgtattttaa aatggggatt ataatgtgag tgtatgcctg 85920 tgtgtgtatg tatatgtatg taagggatta tagcatatat agagttttgt tttgtttttt 85980 ttggtcttga ataaagaaca ttttattatt agagaaaaat attagtcctc ggctgggcac 86040 agtggctcat gcttataatc ccagcacttt gggaggctga ggctggcgga tcacttgagg 86100 ttaggagttt gagactagcc tggccaacat ggtggaacca cgtctctact aaaaatacaa 86160 aaattagcca ggtgtggtgg tgggcacctg taaacccagc tactcaggag gctcaggcat 86220 aagaatcgct tgaaaccagg aggtggaggt tgcagtgagc caagatcgtg ccactacact 86280 ccagcctggg cgacagagca agacgtagtc taaaaataaa taaataaata ttagccctca 86340 tggtagagtg ccaataaaaa cgtttttttg ctactatttc atagaaacct tttgattttt 86400 gaataattta aacatttttt ggtaaagaaa gaaaattcct agatactttt catctagcct 86460 cccctaattt tatcactaca tagtgtttta actcaggctt tttctatctg taattaaatt 86520 ttttgctaac tctgcatcta caaagtgaag ttttaatttt ttttttttta attgagacgg 86580 agtcgcactc tgtcacccag gctggaatgc aatggtgcga tctcagctca ctgcaacctc 86640 cacctcctgg gttcaagcaa ttctcctgtc tcagcatcct gagtagctgg gattacaggc 86700 gcctgccacc acacccagct aatttttgta tttttagtag acatggggtt tcactgtttt 86760 agccaggctg gtttcgaact cctgacatca ggtgacccac tcacctcgac ctcccaaagt 86820 gctgggatta taggtgtgag ccacctcccc cggctagatt ttctgtttta taaagcatgc 86880 ccgccttctt ttttcttcct aggttactat aacaacagta ccaaggtggc tgtgaaaacc 86940 ctgaagccag gaactatgtc tgtgcaagcc ttcctggaag aagccaacct catgaagacc 87000 ctgcagcatg acaagctcgt gaggctctac gctgtggtca ccagggagga gcccatttac 87060 atcatcaccg agtacatggc caagggtgag ttcctcccac tgcccagagc ttgcaagggc 87120 ttcaaactca aaaagtaaaa tgtgtaagtg ttcagaggtc actcaactag tttaattatc 87180 aaacagtata cccactaccg aaaaatcagg aaatatggga agacaaagca gtttataaac 87240 ctaatcacca gaagtaatcc atgtcacaga attgaaatct aatcctcctg ttttctctgc 87300 atctgcctgc gtgtacctat tgccctgaga atagtacccc atatctagta gcccccaata 87360 aatatttatc aaatgaatta ctatgtattt caaaaaggaa tttttgaaat acatatgctt 87420 aaaatgtgaa gagttcccag aattctaata ctacagattt agtacggatt gttcagtacc 87480 aaattcctct ttcatttttt tttttttttt tttttttttg gaaacagagt ctcacactgt 87540 tgcccgggct ggagtgcagt ggtgcaatct ctgctcactg caacccctgc ctcccgggtt 87600 caagcgattc tcctgcctcg gcctccctag tagctgggac tacaggcacg tgccaccatg 87660 cccagctaat tttttgtatt tttagtagag atggggtttc gccatgttgg ccaggctggt 87720 ctcgaactcc tgagctcagg caatctgcct gcctcagcct ctgaaagtgc taggattaca 87780 ggcatgagca cccagcctct atttgttctt tagcgttatc taatattcat tttccttttc 87840 agcattatct aagtgttcag ggtgtcactt ttaaatatta atgtttttta aaacttgtgg 87900 aggttaaagt cctatgtaat catagaattg ctggagaata gacttcaagc aatcaatttt 87960 tcttctactg tgatcacctt catatacaag actttgaatc aacatccttc ttcctttgtt 88020 cacctccagt tcaggaaaca tactaataaa ctgccaaatt attttttacg aagtcctcag 88080 aagtaatgaa gaaacataag caatgatcca ggattaacaa tcatctcatg cacaatggag 88140 atgatagtat gatgtcatag ctgaatagat tcaaaagatg aatattacat tttcttattt 88200 aatatctgtg agtatttcaa aatatcagtc actcagagtc tttccaaaca atggcattgt 88260 ttgttttaaa gcaaacaaac caattagctc ttgtggcttg ggttgccata tatagcccag 88320 aaaccaggct cagggccaga caccttatag gagttcagta aatattgttg aattaattaa 88380 cttagagtat tcctaatgat aggtataaat atgagttttc ctatgtaaca atgcctaata 88440 tatatatata tttatttttt tgagacagag tctcactcta tcacccaggc tggagtgcag 88500 tggcactatc ttggatcact gcaacctctg cctcccaggt tccagtgatt ctcctgcctc 88560 agcctcccaa gtagctggga ttacaggtgc ctgccaccat gcctggctaa tttttgtatt 88620 ttttagtaga gacagagttt caccatgttg gccaggctgg tcttaaactc ccgacctcag 88680 gtgatctgcc tgccttggcc tcccaaagtg ctggaattat aggtgtgagc caccaagctt 88740 ggccaacaat gcctaatatt tattgagcac ttactatatg ccagactgct cttggtgctt 88800 tccatgggtg atctcactta gtcttttcag cagcctgagg gctaagtact attgttctgt 88860 gtcatagatg agatagcata acgtttactg agcacttgct acctgtcaac catcatggta 88920 tgtgctttgg atgcaacctt tgattccaac cccccaaaac tgtaatatag cctctagtac 88980 atgcccattt tacagagacc tagatgaggt aaacaacttg accaaggcta cccgtaaggc 89040 tggtacttaa agttctaggg gaaaaacagg tcttgcttta gagatgaagc cataggaggt 89100 tggagagttt gttcagcagc acactccttc ttaggtaggt ttccactttt ttccaaagca 89160 cagttcactc atcaaatatt ctttgaggct gggcgtggtg gctcacacct ataatcccag 89220 cccttttgga ggccaaggtg ggaggattgc ttgagtccag gaatttgaga ccagcctggg 89280 caacatggtg aaatcctatc tctacaaaaa aaagaattag ctgggtgtga tggcatgtac 89340 cctcagctac acaggaggct gaaagtggga ggattgcttg agcttgggag gctgatgctg 89400 cagtgagatg taatcatgcc actgcgctcc agcctgggtg acagagtaag accctatctc 89460 agaaaacatt cattgagcac ctacagtaag tgccaagttc tgtgcttttt gctgaataca 89520 gatgggagtg agcctggcca agtgtctgca gagggcaggc cttccagtga gctcgctaaa 89580 gattgggagg tggcagtgag tggatcatgg tggcaagtac tctgaaatgc atggttctca 89640 gacacctgta gtgagaaaag tggtatccac ccacattctt tctcacctgg agcacatgcc 89700 atgtttcaca tcaggtcaaa ggtaacagat tagaggggac tgcgtttgac caatgccagg 89760 aaaaggcttt atataaccat acagaattgc aaagccaatc attttgtggg gagttcccct 89820 gtaatagtaa tgatgatgtg aattttgttt ggattttttc ttgtgtgttt ggaatgcact 89880 aacttgttct ttctttctcc ataggcagtt tgctggattt cctgaagagc gatgaaggtg 89940 gcaaagtgct gcttccaaag ctcattgact tttctgctca ggtaacatat tcaaaaagcc 90000 ccgtgtgcac gtgcatttgc aaagacttcc ctgcgtcaaa ttcatgaagg agttattgtt 90060 ccagggagaa ggaatttctg ttgaatgttt cccagcagca gttatgagaa aaagaccttc 90120 cacaatacaa ttcttggaga tagtaatagg acattcacat ggattgtgtg tacgtgttga 90180 gttttgacct ggatatcatc ttctataaac caagtcaacc tctttatgtt catttcataa 90240 gtcatagaaa cagtgcagct gaatcaatca ctttctcagc atttgggaga ggcagttcca 90300 tgctatgtaa gcacagcagc ttttaaatga tgcgtatgtt ttatttaagt tacgaatcga 90360 atgtatggat acttttaagt cctctgtatt cttgaaaaca gaggaactat gtcactttcc 90420 tgctcctctt ctcgctcctt cttgttggat gtgccatcag gattctgtga aatattcatt 90480 tgtactattt ttagtactag cctaggagtt gcctgtttat ttactttgga atcacatgtt 90540 tcctgaagtg tatttaagag cagaagcaag ttatccagaa gccccacaat gtgcccaaaa 90600 tatcaaggaa atgcacactt gaatgatgcc agctgctggc ttttactagt ttcattgtgt 90660 ccattagtaa tgttcagcag tttgcttgct tgtttctcag tattggcaat cggtggtttc 90720 atgaagccca gtgtatgtag caaaagagat ttatagaagt tctagggaag actggtccct 90780 atagtcttcc tttttcactg ccacttcttc cctcacaccc tcttttagtt aggaaattgc 90840 tacggccttc ttgggaatac gagatccaag gaatgcatga gtacagaggt gaagcacctc 90900 acctaaggta gggctggaca caggttctgt aatagagcat cgtgggctaa gctggcattc 90960 agcacctgga gactggagtt tgtgttctgg ctctgccact cgatagctat accgcttcca 91020 tttcagaagc cctttgccta tttgggctac tttattcacc tgtaaaacag aatggtaatt 91080 cctgctttaa ggagatgttg ttgagagtca catcagacac agatgttgtt gtgtcacatg 91140 cttggcacgg acacaagcac ctcagagcct gctggtggaa gctgggaaaa cccaagggag 91200 ggcaatgccc atccttccag taaaggtgtg tgatgggtga gtcacagtgc tcaggcatcc 91260 tctccacctc cgggacttgg caagcctaac aggttcctca tctgagttgg aaattcaagt 91320 gtgccctgaa atgccaacat ctaataagaa agaagcataa ttgctgtggt ggaacagagg 91380 ggcaaggaaa ggacccagca gccctgcctt tttagccctg tcctcaaagt ctatgctggc 91440 ccctgggagg ctccatggga ttccaaggtt tccagaacta tagtttgaaa accacctctc 91500 tgcagtaaga ggaataggtg gggttgggca cagctctaga acccgtgtag aaaacagatc 91560 aggaaatgga gaaagcagaa gtctgataaa cttgggccat acttacacgg atcaatgagg 91620 ccctctactc aggtggtgat ttgggtgtcc ccatgggtca agagacttga ggagtgtaac 91680 aaaggtttgt cacacttgta cagggctatg gaacatcggg acacatggcc tggagggcct 91740 gagtggtcac agccgttcca tctgctgggg gtctgatctg tacccacagt tctttagagt 91800 agaagttaca cacattgggt atgtactgta cccggagaat gactttattt tgtcacatgg 91860 gtattttgta ttgggttttg catggcttat cttgtaagac tttatcttga catagtcaaa 91920 gcttttaagg tccaagtcaa agcctctatg ctgagtcttt aatttagtga attactacca 91980 ttacctcgaa aagtaatttt tctaacctcg aagagtaatt tttctaacct agaaatgaat 92040 agggggagaa gctactttct agaccttcat agcttacgag gaagattacc acagagcctg 92100 gcattgactg tgactgttgt gctgtggatt ccagggggct tcagttgact ctcctgtcaa 92160 ctgatggggc tgagccccct cggtgacagg agggcctggg ggcaatcaag gtcggcacca 92220 gtggtctcca tccaagccag tttaccaaat ccagcccgtg ccaggtgaac tcatgttcac 92280 aggtccaggg tctctttcct agcagtggcc ccttggtgga acccatagtt catctggctc 92340 aagtgcatga actgctcagt gtcactggga gagtcacggg tcagcagcag ccggcaggac 92400 cctaagtatg ttcattcagc acaaaattca ttttccttac aactaagcac tggctccatt 92460 tgagttcatc tttgctcaag ctgcaaacct cactcagact ctttcccagc ccttccctca 92520 aggtggcgct ggtgagacca cctggtctcc atccttaatc attatctgct tcttgtacct 92580 gtggcttttc ttattataat acagataatt tgagaaaggg gtcttaccct tggcaacaag 92640 gagtagggcc tgtacgcttc agcttcagcc tgaaatccca taccttccac ttctagtttc 92700 tgctcactgc gcctgctccc tcgtccgcct gggatgccct cactgatgac cactgctacc 92760 cagtgctcct cctcctcctt cacacacctt tctgaaatga tctgtctgtg ccaagaaggc 92820 catctctgca ttatcttacc tttccttctc tatcatgtgc cactaattaa atctatcact 92880 tttccatagt gcataacatg acaatagaat tattattaaa gctgccccac ggtgacagag 92940 atccctgggg cccagatact tcgataatcc aaccttttct ataccttccc cccactttac 93000 tatttagggt ggaaatttag ggataaagca gaagaggaat tacagaagtc catttgctgt 93060 gtcagctcta actaaacagt tagtaggctg tgcgataatg atgcgacttg ctgtcttcca 93120 taaccgttgt caatagcgtc agagttggga aattgaatgt tcacaagggg tggttaaatt 93180 cagcagattg tcacaatgag agattggtca ttgggagtag aaataaccca gtttacttaa 93240 tcctagccct agaagaataa gggaaactgt gaggggcaga gttgggactt ttcccaccat 93300 ctgtatctgg cctcttcttc ccgctcccca ctacccactt ccccatgccc tactctcccc 93360 tccgcattcc cctgtcaccc attgagacag aaagtggcta agtgcacgtg acagcctcac 93420 agttcatgtg agagctgatt tcatcacttc ctgtctcaga atgagttctg aaagacttgt 93480 ctgagctcaa gtgtaataat ccacactctc caaccatcca tagcccattc aacatagatc 93540 aagaaatcct gactacagca gctttaccca ctgcttttct ctttgtatta aattaagcaa 93600 tttagtgctt tttgtgctga aataggaaaa tacctctttg gaaaggaagt ttgatacttt 93660 cagagcagag agactttgca taattccctt ggcttttagg ccctatgtca gagaagaaaa 93720 atgaacttgg aaagaaaagg ggttaaaacc agtggggatt tccttcacca gaagctgaga 93780 tggaatcata gacatgtcaa actgagagga aagagcagtg aaaaatttac agttgcagtt 93840 tggagagcaa ataaatcatc ttgtaattca gaccaagtga atcaaagcat ttattactct 93900 ttggtggcgg tatctctgaa gtgcaaaaat tactaaaaat ggaacaattg tttgtgagtt 93960 aaatgtcagt aaaaactgca aaatcaagcc aaacaaagtg gcatgcacct attgtctcag 94020 ctacttggga ggctgaaacg ggaggattgc ttgaggccag aagttcagga ccagcctgga 94080 caatgtggca agaatctgtc tctttaaaac aaaacaaagc aaaacaaaaa acttgcaaaa 94140 tcagagttgt tgtaattatc atggcaacaa gtaacattta ttttagcttc ttctggttga 94200 tacagcactt ctacctccat tatctaattt gagcccaaca gccttgaaag catatatttt 94260 gttgtttagt acctcttaca gataacgagg taaacttgga cttggccaag gttactgagc 94320 tagtatgcgg aattgctggg acttgatcca gggacttctg actcaagata actgattctt 94380 tcctctgcag cctgctgttg tctcatggtt acagttgctg ttatggtcat tttgcactca 94440 accctactgt gatatgcatt ttccccgtta tggattttga ccatcaaaat taatgttttc 94500 tttagctttt tccacttcaa aagtctttat tgccaagatg gaggttatgc tcaaggtata 94560 ttttaccccc agtattaaat ttaaagccac attttaaggt ggaaattggt aaaatgagga 94620 aggtaggaaa actctatcta ggaagttctc gacctttttg agtaggaggg ccttttaaca 94680 gcagagcttt ctgagcacac cctcatggtt gtagctactg agtgagaaaa cagtgtatag 94740 attgggaagc ccttgtaata tctcttggtt gaaactcacc agtatgttgg tcgtaaatca 94800 ggcttgaagg gtctagaggg ggaagttctt gggaagtttc tagaatattt gccaatatca 94860 tccaaagtgg gtctcttctt ctgtctcttt gtctggaacg taagagatgt gttagacgct 94920 catattccac ctcaaggcta ttatcccagt gaatcaactg ctttatcttc aaagccttga 94980 ttagtaacaa cctttgattg atagcgtcct catgtttagt tcactcaagc tggagggaga 95040 gttgcattga gatgtcgagt cagacgtggt ggcaagtgga agccgcaggt gattgacatg 95100 gtttgcggtt taaccaggag gccagatccg ctccccactc catatataat ctcccctcca 95160 cgtggaaatt ctcatacatg actcttactg aggcctacac attcccaatc gctctttcaa 95220 gcacaagagg ctccttagag agaaaaacag ccagcactga agaaggcatt catgaatttc 95280 atagaggaat ctgagccggg tgccgctgtg gattcagggg ccacatagtg gtcaggatgt 95340 gatggtccct gagtgggcat tgcttggagc tgatgcttgg aaacctcagc tttctcagta 95400 tacaaatgtt aacacagctg gtggttagct ctttctcaga atttgagaaa tgttgccatg 95460 attttgtaaa tggagcctag attatgctaa tgatggagaa atcactgagc caagaaccag 95520 aaaacctgct tctgcatggg gaaaatcact ttgtgggcac cagtgtcctc gtctgtgaga 95580 tgggaggcac aggttgggtt tcccacagcc tcagctctaa tattgcatga ctaaggacat 95640 ctccttttat ttagactatc tatgtgaatc gtcaccaaaa gttgcaacta atgattctga 95700 ggctatgcag atgacattga tataagattt tagcattgct ctaaataagg gaacacaaat 95760 atatcacttt aatgcagtac ttacatgttg ggcacttaaa tgctctattt atcttttttg 95820 aataatgagt gttatgtttt cagcttaaac tttgaccatg aaaacttaga aaatggacaa 95880 atgaaactag ttactgtcag aattgcaaaa gtggatcata tgcagtttcc ttctgaaaaa 95940 gccaaaggaa taggaaactg tcatttaaaa atagtataaa acaggaactc tttttttttt 96000 ttggtaaggt gggggtgggg ctgttttgca tatttaagca agaggaatca tgactggctg 96060 ttaaaatagc aaataaggca gaatttattt ttgctttaaa tttgattggg aagctttggg 96120 ttagtgtatg gcagaggtgg tggtgctttt ggcctgcagg caagatctgt ctcttatctt 96180 aatgttattt tgaccagggg tggcaatttc tggtgagtgc taccgtaagt cacaaaatgc 96240 tattctcttt gggtactcat catggaagct tgcagggcta gaattcaact gaagtggttt 96300 aggagtgggc agagtttatc accagctggt cacagttgaa aagtggagat gaaagcagtt 96360 tgaaattagc caggcttggt ggtgcgtgcc tgtaatccca gctactccga aggctgaggt 96420 aggagaatca cttgaaccca ggaggcagag gttgcagtga gccaagatca caccactaca 96480 ttccagcctg agtgacagag caagactcca tctcaaaaaa aaaaaaaaaa aagaaggaag 96540 gaaggaagga aagaaagaaa gcaagaaagc attttgaagg gagcagtgga gagtaaattc 96600 cagctgacct ttgtctccag cacttggctt gctctccctg agccccctca ccctcttggt 96660 gtggcccgct ccctttcact cacacagcta tcctgagcac agccaggcac tgtgtcagga 96720 gggatgagca aacggcacat ggcatggagt gggggacagg tgagttgcag gcaaagacag 96780 ggtacagccc tgggatatgg caagggctgt cagagtgggc accgcatgct actttcagag 96840 tacatggagg aggatggagc gtagtagggt gggctagcag gtggaaggtg ggcttcctgg 96900 aggaggtcac cctgagagcc aggattagcc ctgctagctt gggaaggggt gtggctgcag 96960 ggatgggtct tcagttgtag gaacctcgtg cataaaggca cagaaaagga gtacacgggg 97020 atgcaagtgg gggtatatgg agagaacagc ttagggggca ctctgagaga catggacatt 97080 aaggaaacta ggccgagcac agtggctcat ggctgtaatc ccagcacttt gggaggccga 97140 ggtgggtgga tcacctgagg tcaggagttt gagaccagcc tggccaacat ggtgaaaccc 97200 ggtctctact aaaaatacaa aagttagccg ggcatggtgg tgtgcgcctg taatcccagc 97260 tactcaggag gcttaggcag gagaatcgct tgaacccaga aggcggagat tgcagtgagc 97320 caagatcgtg ccactgcact ccagcctggg caacaagagc aagactctgt ctcaaaaaaa 97380 aaataaaaat aaaaataaac tagaccggtt cattctcagt tgtggaagac taaactgttt 97440 tgtagataac tctggtttaa aaaatgtatc tgtacaaaat aaaaatgctt atactcagca 97500 aatagtttca acaggactta cagttttacc cttttagtca aagtaggcct ttaaatcatt 97560 agtggatgct ttttgtattt actgtaatat gtattcatgt tacctctgtt ctcccccaac 97620 acaccagggt gttctttata gaaattggtc tgttttgact tttggagaat cacagagttc 97680 tcagcttttc atgctcctaa cattttgttt tattactgtt tttgttgctg tttttgtttt 97740 gttttttaaa actgagacca ggaagggtgg gatggaaaag gaatgggaga gtttgtgttc 97800 tagcccagag ctcatctctg tctggcacag tggctcatgc ctgtaatccc agctctttgg 97860 gaggctgaag tgggagggtt gcctgaggct gggagtttga gcccagcctg ggcaacacag 97920 tgagactcct atctctacca aaaaaaaaaa aaaaaaaatt agccaggcct gatggtcgtg 97980 cctgtaatcc cagctactca ggaggctgag acgagaggat tgatcgaacc cgggaagttg 98040 aggctcaagt gagctatgat tacacccacc gccctccagc ctaggtgaca gagcaagacc 98100 ctgcctctaa aaaaacaaaa caaaagcaaa cagagctcgt ctctaaaggg tacactctga 98160 aacggacagg acttcttctg agctttttca attcagagct agattctcag gccctctccc 98220 caacccctca ctaaagccaa gaagcacctg aaggagttca gcccaagtct ggagatactt 98280 aaacctctca accaagtggc tttcctggtg ctgtccctga agcaggtgtg aggcctgagt 98340 tatgaaactg aggtgggttg cctggggata atggggatcg actgagcatt tcagcaggaa 98400 tgtgatagga tgagacctgt gctttaaaag ttgccccagc caccgtatac aaaaatgatt 98460 agaaggggtg aaagctagag tccagggatg agggagggag gatgggcctg agcgaggtca 98520 gtgttgccta tcacaggcac atagaaatag agaaggaatg tgcatggggc agctgaggac 98580 cgccattgcg ggcacggggt tgaggtggct gatgaaatta gttttgctgt actgggtttg 98640 aagtgccatg aaacatcagc tagagatggg cagctagcgt ggacaggcat tttagtatag 98700 gggtctgggg ctagaggctt caaggaggct ggtgctgcag acagtcatat aaataggggt 98760 tggatgaggt cccctagaga gtgtgggaag gggcagagga cagccccaga cagaccctaa 98820 agaaagggct gagagggaca agtcagagag caggctgggg acaccagaag cacagtggcc 98880 tgtaaggagg aggtggggtt gcagcgcagg cgacggagtt ctgacacgca gtcagagagc 98940 agggaaactg ccacgggact ttgcgacagg gaagtctttg agaacctggc tggacccttc 99000 tcagtgacat ggtttgggtg gaagccaagc ccttggcctc tctccctctt cctgatccct 99060 agaaccctgt tctctgcctg cacaggctcc tccctagccc tggctgactc ctcttccttt 99120 ttctttctcc tctgctgccg cttttctctc catgcttccc tgaccgctca gcatgcctca 99180 ctcttgaaaa aaatgtgatt tttctctgta cttaaatgaa accatgcact tctcattctt 99240 tttttttttt tttttttttg agatggagtt ttgctcttgt cacccacggt ggagtgcaat 99300 ggtgctcact gcaacctccg cctcccaggc tcaagcaatt ctgcctcagc ctcccgagta 99360 gctgggatta caaacgtgtg ccaccacgcc cagctaattt ttgtattatt agtagagttg 99420 ggtttcacca tgttggccag gctggtcctg aactcccaac ctcaggtgat ccacccgcct 99480 cggcctccca aagtgcaggg attacaggcg tcagccaccg tgcccagcct cattcttgtt 99540 ttttaaagtg gttttcttct gtgatggaat aaaatgaaat aaaattactg agagaggaac 99600 ttaaattatt ggtttttaaa aatatatggt tttgtagact tctgtagaaa cacagcattc 99660 ttcgcctacc ctcggagcac gtgctgtagc tatgcatttg tgtctgtagc tctgcagctc 99720 gtggggcttt gtgaaacaca atgagaagca tctaaaaact gagtcaccaa aagtagccct 99780 tgcccccatt taagaccggt ttgactgaaa tgtgtattct gaggtcagtt tggtgcctgg 99840 aatgcattcc ccaggttttg ctgaggttcc catctcaggc ctccacccag cacagctctg 99900 cagatctcac cctgattcag cgtcacccca ggaaatggtg tgtctgggct ccttggtatg 99960 gtttctaagg cagctcctct ctgccaagca gcagcctgac accctgccca aggctcagag 100020 ggatgccaca gcatctccgg ggctgccaga gggccgccca ccctggtgcg gaagacccca 100080 cccgagctcc tgccatagtt gctgcctcct ggcctcttcc cctccccaca tcaagacctg 100140 ttccttggag atgaggcctg cagctgacag ccctccagag gccctgcccc agtagggctc 100200 agagcccatg tgcacaggca gcattccacc taggcaggcc acagtccccg ggaggtggcc 100260 acacagggtc cccctgagcc atggctttct cagccaatgg tctgcccagc cctcctcact 100320 cataatcaag tcctctcatt tcttcttcca aaatagatct ccctcctcca ggtcaccatt 100380 gtctctcatc tgcactattg cagttgctgc tttttttttg tcttttttga gatggggtct 100440 cactatttta tccaggctgg agtgcagtgg cttttcacag gcatgatgcc actactccta 100500 agcacaggag ttttgagctg ctccgcttct gacctgggcc ggttcacccc ttcttaacca 100560 acctagaggt cctccactcc caggagtcac catattgatt ccgaacttag tgcagacacc 100620 ggatgggcat agcaaagtgc agcccagagc tcctgggctc aagccatcct cccacctcag 100680 actcccaagt agctgggatt acaggcatac accatcgtgc cccacagttg cttcttaact 100740 ggtgttgtcc agtttggcaa acagaagaaa ttcaaggtat acagtcaaat ttggattttg 100800 gataaacact agcttttaac agaagggtgc ccatgtcttc ccaggcagcc ctgctcctaa 100860 tgagcctccc tcctgtctct ttggctaccc tctttccagg ctccacaaag taggcaggga 100920 caattggatg cttttaaaat ttttgccttt ttaaaattgt ggtggtaaaa taaacacaaa 100980 ttacaccatt ttaaccatgt ctaagtttat ggttgttggc agtaagaaca ttcacattgt 101040 tgtgaaacca tcaccaacat ccacctgcag aactctttca tcttcccaga cggaagctct 101100 ttgcccactc aatgccagct ccccgcggcc gcttgctagc ccctggccac ccccgtgctg 101160 ttctcggtct ctgtgaatct tacagactgg atggttttgc atccctgctc agctccgttc 101220 agtgggtccc caccacaccc agagagactc ccaacacctg tgcatgtgac tgattcctca 101280 gcactgagcc caccacgctc ttccctatcc cagtgcctct ccagagccca cttcctggaa 101340 gcgctcaccc tttgttctga gccacaccac acctcttatc aacaggcacc ttccctgacc 101400 ttccttctga agcagttcca tcccaactcc tgcttactcc attctcctca gtctcggtcc 101460 ccgcccattt cttccatagc gtgtactgca atttgaattt tttgataagt tcttctttac 101520 ctttttatcc ccagcacttg gtgcagtgcc ttgtatatag tagatgctca aaaatgcttg 101580 ttggatgact atactggcca cttaaaatgg ggattgacta tattccgttt aaaacaataa 101640 attctttatt ctctgcttca tacagctctg aatgagtaac tagaagaaca tattttttgt 101700 gtgtttaaaa aaattttttt taatatagag atagggtctc actacattgt ttaggctggt 101760 cttgaactcc tgagttcaag cagtcctccc acctctgcct cccaaagtgc tgggattata 101820 ggtgtgagcc accgtgcccg gccagaacac atgcttttga aaaggttttc tgagtcatta 101880 ttcaggtgta tttaaccata aagtattttc ttcttcccct tcctctaact ataggtttac 101940 tttcctgtac aaaacttact tcattggttg aaataaaagt gagaaaagaa gaaggaagta 102000 gaatacaagt atctgggcct gtgggaaaaa caaagtgcag ctttgttttg cattccttgt 102060 ggcataaaga acaccaggag gaatgagaaa ttataaatga agtatttgac attgaagcca 102120 acggcagatg cattctgctt aatttggagg gaaaaaaccc cacaactgaa caggtttgtc 102180 ctcccccagt gtcatgcagg gcctctcgtg gcctctccct gggcgctgaa cagagccctt 102240 tctcagcacc tgttggcaga ggttgatgct agagttccca gggtgatggg ctggcggatt 102300 cttaacaaag tcaggatttc cagctcttgt tcattttcca cccagcgccc ccagtgtctg 102360 taacatcatt atctggcaat gttatatgtt acagagccaa ctacttgcat gattattaaa 102420 attacattta tacttcaggt tgagtatctc ttattcaaaa tgcttaggtc cagaagtgct 102480 tcagatttgg ttttgttttt tttttaatcc tcagattttt gaatatttgc attatactta 102540 ctgattaacc atttcaaaaa gttttgaatc ttggagcaat atggattttg ggtttttgga 102600 ttaggtatgt tcaacctgta gtattgtcaa tggaaccaat ggtgtgctga ggtatttttg 102660 atgcattaca aggagctgta cggcttgatc ttcttttcca tttccagacc ttctacctcc 102720 cccacccagg acccccagct ttggagtcca cgccatcaga ctgtgccagt ctgactcact 102780 tcactgctgt ggtcctcgga tccccgaaca ctcctccttg ctgtggtcag ctccggctgg 102840 cttgctgttc ccagcacagc cctgtcatca ttccatcatt tgtagccatc cccaccttca 102900 aatgctggct tctctgtgtc ttgacttcct cccctccaag actctgtcct ctcccctcga 102960 gccactctgc aggctgacca attctgctgc tcattgcttc atttgatcgt ttccacttca 103020 gccattgcct cccttctgtc cactcaccct cctgcagccg ctccagcccc tacagcctca 103080 gcctgtcacc agcacttccc gtcccttgaa cctgcctgtc cctaccgccc ctccgctcct 103140 gcttctcttc tctcctcccc tagcttggag acactcattg cccctccccc atgtcacacg 103200 cacctggtaa aatgccagcc ctatggaagt ccgacccttc acctattttg ccctcatgtc 103260 cacacaacag ctgtgacctg cactgagatg cctagcagct ttctgcattt ccagttcaag 103320 agcaccagcc tgaggagcct catgaacccc gacatgtgcc cagtctgctc cctctcactg 103380 cctgctagaa acaatgcccc accttccctt tctctgccct caaaccttcc cctacttgcc 103440 tctctctgtg gattccctgc tgtctctttc cctgagacaa gagaagctgc cagccaagag 103500 ccctgacatg catcaggtct tgtgctctct tgctgtttca agacactgtt ctagaaattc 103560 cgcattagcg ttttccctca cttctgcact tcccatagga atcaaagtaa agccttcact 103620 ttcccctaca tccctctcca gctacctcag cctccaggtg tctcctcccc ctgacaacag 103680 aagtgtttta ggaactatgc tcagtttccc ccagttcttc cccacccgcc ctctcttgaa 103740 cctcccaccc ctcgacccca gcagcacaag tcagcagtga ccctcaggac actacatcca 103800 aagggcaccc atctctcagc atcttcctag ctgcccacca gcagggtctg ctattgtcag 103860 tctcactccc tcatggcacg ttttcctcat ttggcttctg ggacactgtt ctctgctttt 103920 ccttccccct caccagccag cttctcattt gcccagtggt taaaccttgc aatgtcccag 103980 aactcactct ttcaacctat tttttctcca cactaagtct cctaagtgat tccattgaaa 104040 gcattgtatt aatttcctgg ggctgtcagg gcgcttaaaa caatagaaat gtattttcct 104100 gcagtcctgg aggccagaag tctggaatga aggtataggc agggctgtgc ttccaggttc 104160 ttgggaagaa tccttccgta cctcttccag cttctggcag ctccgatgtt ccattccatg 104220 tcttgttgac cgcactgctc ctcttcccac ctctgtcttc cggtggcctc tgaccttcct 104280 ctgccttctc tcataaagat accagtggtt ctatttaggg cccaccctaa atccagggtg 104340 agatttcatt ttgagatcct taattaaatc tggaaagact ctatttccaa ataaggccac 104400 attctgaggt tccgggtggt cgtgagtttt ggggggacat tagttaatcc agcacagctg 104460 tctagactcc ggccactccg aagcttctag ctcagcccaa actgctcccg tgagcccctg 104520 ctggctcagc atctgcccaa agatgtgtgt tgggcatgtc aaactcaatg caccccaact 104580 cagtgcctat tacccccttt tccaaaacct gtgccagcag ccatcttctc ccttttgttg 104640 atggcacctc tgtccttgga gctgtcagat cccaacactc aaagtcattc ttgaccctct 104700 tccttttaca ttgtatatcc aattcctcag caagtctggg gttctaccct caaagtagat 104760 tcaccttcct aagtcctgca catggtcact ctgacccaac ttgaatacac actcaaagtg 104820 agtaatctag gagctggctc tctactcctg tgctcagctg tggcttcccc cagcccagtg 104880 gtcacacagc agtcagagca atgctttgag gcataaatca gataaccccc tcactctcag 104940 ccctccagtt cttcttggct tcactcggaa tgcaggggga agcccccata aggccatttg 105000 cctgcagtgt gtgtcagtca tgatgtagat ttgctttcag aagttactcc ttttcataca 105060 ttttttattg tcttatttgt ttggaaatct atgtttcagg gtttcatgtg cttatcatta 105120 aattcacctt ggattcttgt ttaaaatctg caggtgtcta ggtaggtccc tctcactgtt 105180 agcagtcatt aaggactagg gccctgaata agccgcaggg gtcctgtggg cttcaatagt 105240 cgggaaacac tgccattgag aagttgctga accgagcaag tgatcctttt tctaggtcac 105300 gcatcttgca agggaatgct gcttttcccc attagaaagc tgcactgctg gggaggaact 105360 gtacttctct cactgctcta agtgagtgaa acccagtaat tgtttgctga aatcactagg 105420 catggacaag tcctacctgg tgagcaaaat gcttgacctt gcttcttcct cagcttcggc 105480 ccttgcagcc acacccacct gctcttgccc ccacatcctt aggtaaagga aaatgcagga 105540 gcagccacag agagcagacg tcacaggctt ccctcgcaaa cacatggtat tttgaaaacg 105600 cacttcaaag gggttgaaat ataaataaag aggatagcaa atctgtttca ggtatatttg 105660 gaatttgtta gatcttgtta cagatttcct ttaagtttgt cacaggacaa ataagtcagg 105720 gattgttttc ggagcccagg cgctgtcttt atacaggaat tcttttcaga ataacacaca 105780 tcaagttctt taaggtattt tgtcttagtt gaaatatagc acagctgcct gctatgtatt 105840 ttcttcttct cagctatctg acatggtgta tattcatgtg ctggattatt attttctgtc 105900 ttcccccatc aaagagtaaa ctctgcaggc aaggactgtt tagtggacct gcaactgggt 105960 ggggcttgtg gcatacaggc aggactgtgt gtggttggat ggaaggggga atgtcagttc 106020 tcgtaagcta atggagatac cttgaccttc agtcttttaa tatactaagg gtgaccaggc 106080 tcagtggctc atgtctgtaa tcccaacatt ttgggaggct gaggcaggag gatcagttga 106140 acccaggagt tcgagacccg cctgggcaat atagtgagac ctcatctcta caaaaaaata 106200 aacaaaatta gttgggtgtg gcagtgagca cctgtggtcc cagttactca ggaggctgag 106260 gtaggaggat tgcttaagtc ctgtaggttg aggctgcagt gagctgtgat cctgccactg 106320 ctctctgtcc tgggcaacag agaccctgtc tcaaaaaaaa aatccaccag aatccccccc 106380 gcaaaaaaaa acgctacctt atgtatatgc taagggagta gtcatggcat ggcatcctag 106440 tgacattaca aatagcagcc atatcccttt acattcctgc cagcagtgtg tgagatttcc 106500 agtttctcca catcctcact aacacttgtt attttctggg ttttgataat atctatcttc 106560 ggggtagtac agtgagtttt gaaatatcta tcccaaagac atagttcagt gagtttttgc 106620 aagagaaagt aaatgggtat tcattgacaa acttttcttc ctgttttcta aagaaggtaa 106680 ttctgtttcg tggacactta atgatttaaa tatgggtatt tggtgaagct gtcattttga 106740 aaatcatctc tccctaaggc attgtgggtc cttgcatgct gacagattga ctagattttg 106800 agcagtcaca gaaatctcca ccagccctaa gcttggatat gccaaacact gcctcatctt 106860 tgagctatga aggtagtcta acagactgca agctttaact tgactgttta ttatgattat 106920 tattatttta gagacaggat ctctttctgt tgtcctaggc tagagagcag tgatgtgatc 106980 atacctcact gcagcctgaa actcctaggc tcaagcgatc ctcctgcttc agcttcccag 107040 gtagctggga ccacaagcat gtgccactac acccggctaa tttttaattt tttgtagaga 107100 tagggtcttg ttacgttgtc cagggtgttc tgaactcaag tgatccttcc tgctagtcct 107160 cacaaagcac tgggattaca ggtgggagcc gccacattcg gcctaagttg accatttttt 107220 aaattatctg actttcttat ttctttttgc ctcttttttt tccactgcca acttggtgag 107280 cattgtattt ttagaataga ataaaaagaa tcttttcttg ccaggcgctg tggctcatgc 107340 gtgtaatttc agcactttgg gaggctaagg caggcggatc acctgagatc aggagttcga 107400 gaccacactg gggaacatga tgaaacaccg tctctactaa aataaaaaaa attagctgag 107460 tgtggtggcg agtaggtccc agctactggg gaggctgagg cacaagaatt gctcgagccc 107520 cggaggtgga ggttacagtg agccaagatc aggcactaca ctccagcttg ggctacagag 107580 tgagacttca tctcaaaaaa aaaaaaaaaa atcttttctg tttatttatt tattttgaga 107640 cagagcctca ctctgttgcc caggatggag tgcagtggtg cagtcttgtc ttgcaacctc 107700 cgcttcctgg gttcaagcct cagcttccca aatagctggg attatgggtg cccgccacca 107760 cacctagcta agttttgtat tttagtggag acagggtttc accacattgg gcaggctggt 107820 ctcgaactcc tagcctcaag tgatccaccc acctcgtcct cccaaagtgc tgggattata 107880 ggcatgagcc accatggctg gctcaaatcc tttcttttta aaggaaggag ccaatgtgga 107940 tgaatgctta agagcacaga ctcttaagcc tggaccagcc agactcaggt tggaatcctg 108000 gcctttctag ggaaattgta acctctccaa gactcagctt cgtcctcgtt actatgaata 108060 taacctactt tatgggctta ttttaacgac taacatgcct agcacagtgc ctgggcaagt 108120 agtagctaat acatggtagc aatcatcatc atcatcaaag tatagatttc actatttctt 108180 agcagttata cttggaaaag gagattatta tgataaccaa ataaagctaa aataaaattt 108240 ccaagaaatt ttgatcccaa aaaagtagag tacaaacaag aatgcatgag ctctctgttc 108300 catccctttc ctccatccaa attatggatt ggagattaga ggaatctagt gttggggaat 108360 caatgaatat taacaagtag aaaagtgttt ctgtgacaac tgttgagagg tataaaacaa 108420 atgctgtcat atttgcagta cagacaagtt gagttcttaa actttttgca aactccctgg 108480 tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgttta catcctattt ttttgttgtt 108540 atcattaaat ggtcttttta ggtcagtttg ggattgactc caggggcttc ctgttataaa 108600 aaaatccttt agagagactg taggttttac tcaatttcta cttatttttc agttccaact 108660 tattaatatt gttattttat aggcatccta gggcttttga acatcattaa ttatgtgaat 108720 tcttcttttt ctcaagcata ggaagacaat acatccttag agagtaaggt aaacagtgtc 108780 tactaaaaca ggtaaagcac caggaaaatc agatcttcat ttttcctact ttttgacagg 108840 tttctcattt aatttttctc actgcttgtc tagatgacaa atgttttcca agcagccaat 108900 tctaagacag gttgcgtttt cagttccagt ttctcattta ggctggaatt tcctggggta 108960 gtttttagct ttgcttgaga gatcacattc agcccctcag tgaggttcct ttgatccctt 109020 ttttccctca gtcatctgac agaaatgggg gttcttctca ttaaagtgaa aaaaaaaaac 109080 ccaaaaaaca aaaaactcac cgagcaagat agccttgctt gtctttgcca atttctcaaa 109140 aagcgatagt aattaggatg aacagaagag cactaaagca agatttccag agtgaggtca 109200 tccacagaac acttcattat ttgtccaaag cattgctcat gttctctggt ggtagcagcc 109260 gggtatgtgt gctgagcaaa cagtccacag ggcacatgcc cagcaaggct ggtgatggct 109320 cagagcctgc gcctcgggtg ggagagagct tgctggaagc cggtttcacc gtgtgggatg 109380 ctggggttga cagacttctc actgggcctt tgagaaaagc gggaaagatg aatgacctgg 109440 atggtcatca ctaggaagct actaagcagg ggcattattt gagctctgct tggatttgta 109500 aaacataatt gagattgtgc tctctatcaa acccgcataa aagaagtcca tctgatatat 109560 tacctagggc cttggtggtt aggaatttcc catctctggt gtggtcatag gcaacccact 109620 tctcagtggg tgtgtttgat gacacaaaac cgcagtgcct catgagggag agcccggttg 109680 cctttcctcg agaaggtcca ggcaggtgca tttggatagg gcttgctgag cctactcaca 109740 tggacactcc ccattcagga aatagcaact tggactttct actttaacat tgttagagga 109800 gagggaattt aaatgagtgc attccactca aatgtttcta aaactttggt ctcatttaac 109860 caaaccaaaa accatctgag acaggtctcc atcaatttag aggtttattt tgccgaggtt 109920 gaggaccatg gctcatgaca cagccaccag agatcctggg aacatgtgtc caaggtggct 109980 gggatacagc ttgatcttac acattttagg gagacagaag ttataggcaa agacataaat 110040 cagtacacag aaggtgtaca ttggttcaac ccaggaaggc gggatgtctt gaagctggga 110100 ggggaggctt ccaggccata agtggattca aaaatttcct gattggccag gcacagtgac 110160 tcatgcctgt aatcccagta ctttaggagg ccgaagtggg tggatcacct gaggtcagga 110220 gtttgagacc agcctggcca acatggcaaa acactgtctc tactaaaaat ataaaaatta 110280 gccaggcatg gtggcggaca cctgtagtcc cagctactca ggagactgag gcaggagaat 110340 cgcttgaacc caggaggtgg aggttgcagt gagctgagac tgtgccactg cactccagcc 110400 tgggtgatag agtgagactc tgcctccaaa aaaaaaaaaa aaaaaaaaaa agtcctgatt 110460 ggccattggt tgaaggagtt aagctttgcc tgaagagttg tagtaagctt gagttaaggt 110520 ataggaagtg gtggttgtag aagcaaaggt tcttatcatg tagatgaaga cttcaggtag 110580 caggcctcag agagaacaga tgtgaatgtc tcttatggga ccttaaaagg tgtcagttaa 110640 atctctcctg gatcaggaaa agacttggaa agggaatggg attctctata gaatataaat 110700 ttcccccata agagatggct ttgcagggcc gtttcaaaat ttgtcagaga aatatatttt 110760 aaggtaaaat actttgatct tctttagaac ctgttatctg tcatgtgatg ttatactaaa 110820 gtctggttgg aatttggtat cttattgctg caaagagtct gtttatcagt ctcaggatct 110880 ctattttaat gtgaatgctg gtcattggtg tctacactcc aaaagggaga agggcataat 110940 gagtcatgtc caattccccc ttctcatcat ggcctgaact agtttttcag gtttctttga 111000 aatcccctgg gccaagggga gggtctaccc agttggttaa gaggcttaga attttaattt 111060 tgttttacat gttttaaacc tcataccctg gggaaaaagt tatttgcaaa gtaaatagga 111120 ctctaaattt tgtattctgt ccccactctg cccagcttaa gtgtgtgcct atttaagggt 111180 gtctgtgtgt gtgaaatcat actagagatg tgaatatacc aacaaataga gacacgccgg 111240 cagtactacc acgtcaactt aagcagctgt gtccatagtg gcctctgaga tgctgctcgg 111300 ggtctgaggt ctatccctga tcccactctg ccaccagccc tgacagctgg gttgcctcca 111360 cctggaggaa gtggcacctt ttctcacctg ctgtggcccc aagggtatct ttgttgaagg 111420 gttgacactt cctgtttcac accagcagtg ggggagaaag tcctgcccct ttggggtcag 111480 aacgttgggt aagaccttac ttctctcttt ctctggtcca cttgtgcctc tagctgcctc 111540 aaagccctga cttatggaag gcatctgttc agctgactgg cagtggagga agaggcagac 111600 acttggtgac taactccttt tcttctcatt gtatgttaca aaggccactc tagatgactg 111660 gaagtctatc tatccagcca aacaagataa gcctgcccat taactcagga agcattatta 111720 ttaatatgtt ctgtgcacct agacttttca ttgtgtacaa gatgccaaga gtttcaccag 111780 aaccccccac ccccaggatt tgctctctga cccagtagtt ctgtgcctcc tcccaggaca 111840 gcagtgggct cagcatggtc ttctttgtca tcagcttcag gcacaggcgt tttcaggaaa 111900 caatcacctt gctccacact cagagttttg gtcatggtgc acccccacat gctcccttgt 111960 ccctgtgctc agtaaaccgc tttttaaaaa cgaaaatgaa aaacacagaa acagcacagg 112020 tagaaaatac catcatatgt tttcactgaa ggcaaaaaaa gaaactaaaa aatgtgcatt 112080 ggccatgcta tttgaatcaa agagcacaag aagcatcagc acatctcagc ttaagtcaag 112140 agtatggaaa cctcactgac atcgtctctt tacgtgatta gtctcatttt tggtaatagg 112200 gatgcttttt atttcagatt tccagtagct tcacacatca actttctgag acagagttag 112260 acatcagcac tgggtgaaag agacagttta aattagttct ttggtgtcgg caggtggttt 112320 agaaagttgg ggttttcttg tctttgttca cccctgggcc tgacattata atgaagagaa 112380 tcacatggcc taagatgaag agaatctcct catttggttt agaaccaaaa gattttatcg 112440 gtttcccaag ctctgtgagt aatgtctctg ggcccagagc tgtgatagag agggagagga 112500 gctgaggcct gaccctgtat cccctgcctc caagccatga ggcccacagg gtcctgacct 112560 aagttgcagg aaaaacaagc tcaagccatg tgttccaaac agttgatggg ctaggaattc 112620 ttccaaggtg tttggagaac cttcctcacc tgccctttcc ctcaccccag ctccatatgg 112680 agcctcctcc tccctgcctg ggctccttat gctggccctg cacatcttac tccttctttt 112740 gttaagctga gttgcatctg gacttcctcc ccaaccatta tgatggtaac agtctacctg 112800 tgaggttgct caaaggcaac gtgttgagac taagattttg ttgcaatcct aaaatagctt 112860 aagctttcaa gcctatgatc tagtgctctg cttctcaaac tctaagctct ggaggctggg 112920 aagtccaaga tcaaggcgcc agtagataca gtgcctggcg aggtacttct ttctgtgtcc 112980 tcacatggaa gaaggtggaa gggcacaaaa agggtcaaac tctctgtgaa gcctatttta 113040 taagggcctt aatccaattc atgagggagg atctctcatg acccaatcac ctcctaaagg 113100 ccccccctct taatacgatt gcattggaga ttaagtttca acatgaattt ggagggacac 113160 attcagacca tagcatcatg catttgcagt gggggtaaga ttgcccccaa gggagcaaaa 113220 attgatccct taggggtgat aaaaatctta gatattacaa tagtttgtgg ccctccaaag 113280 ttcataccta cctaatacaa ccttctttcc tcatgtttaa tttctcctgt taaggatgcc 113340 ttaactttaa attttaattt taattcagta attcttcctg gaggaataat aatgaaaaaa 113400 aagtttgaga aacaatgttc tagacagaga caacctaaac aaagttttgc atgtacttcc 113460 tgaaatggga accagaactt ggcctgggga gagcttgtga ttccctttct gaggggtgaa 113520 atttgtactt aacaacaatg agaggaaacc tcagaagtct ctttttatct tctcagagaa 113580 gaagtactct ctcaatgaaa tctttgggtt ccagaagcat ttagttatga gtactgagct 113640 ctcttggtac tgagctctct tgtgggtctg acattctgga gtgtggtgtt agaatcgtgg 113700 actttgaggt cagacacgcc tggtgtaaat gggagcattc cccttcactc tgcagctttc 113760 aactggttct ttaatttctc aaagcctcat ttgcatctgt acaatggaag taaaacctac 113820 ctggtcaatt tgctattaag atgaaacatg aattgagtgt aaaggatgtg aagcagtgtt 113880 tggtgtatag taggtgttca attagtggtg gggaaatggt ggttattaat atccatctac 113940 ctacccacct acctatcatc atcatcttag taaaatgtct gtgggcacaa aacaacacaa 114000 caatcttctg aatcaaacac atcctcttct catcaagctt gaccaactcc atgtaactcc 114060 cacagaagtc aagctttcca agctgctgga acaataggaa gtgggagtcc ctggggacag 114120 ctgagccttg gtttatgtat ttatgtgaca gctctttctg tagtgctgaa cgctacatgg 114180 ccctggaaga ggaagaaggt attccatgaa aagttgacac tacattcaat cagccaaagg 114240 agtctctgat ttcttcctgc tgtttgaaat agagctggat ttacttagcc gtagtaaata 114300 gaccaccttc aacaacaaca aattaaggtt ttaaaaaaaa taaaccaaga aagaacaata 114360 cacaaagacc agggaaagaa taaagagaat gaattaattt tatataaagg gagaggtgtg 114420 atatttatca tctgaaaagc aagtcatatc tgagagcttt tattttgctc ccatattcat 114480 tatttattca acttggctaa tgctgttgtt tctaatcctg tcttggtgaa cgctttaatt 114540 actgtttgga atctgagctc cttaaagcac tctggcatgg aaaagaaggc caaaatacac 114600 taggtttgtt gcaagtctgt tattatttct gagaatcatt tttttaaatg cactcagatt 114660 tatgcaaatg cgggatgtgg gtaggtgtga caaatgcctt actaacaagt ccctggagtg 114720 ctttttgtaa tgagttgatc atcacgtgtg tccttgctgc tgtgtgggag gctgggtccc 114780 tgccatcatg cccacctgtg tggccgatca acagcgttgg gagaggggca gcacaggttc 114840 ctggttgcta ttgtcaactg tggtttcagg cccaatttgg gacttcagcc agctttggct 114900 tctttgggtt cttggcccag tttatatata attattggaa tgttaggtag ataagtgtct 114960 aagagctaag aatttttaaa ggctgcacta ccatggagtg gagccgggag gctgggacag 115020 agtcagctat gaccgctcaa ttgctgctgt ctcatctggg ctcctgtaac caactctggt 115080 ctgtttgagc caggcatcgt ggttctatcg ccaaaagcct actgtgttat aatcgtacac 115140 tcctttcttt cacacatgct cagcctgatc ttcgctctcc acttttccca gttttactgg 115200 ctttttctaa caagtcttgt tgaacttggg ttaccagcag acaaaaggaa acagaggcag 115260 ggctcctctc tcccagccgc caccaaaatt gccaccccgt gtcatctgtt tcagtagtgc 115320 ccactctaga aggagctatc ctgaacttcc tgacgccctc accatgccac tgcctgctgt 115380 ttctgggcag cagaggcttc ctagagaaag tcagactcag gagctctgcc ttcacctggt 115440 tatcaccact gcccaccttc tgttgacttc ccatcaaggc tgtttgaatc ttttccaggg 115500 tcaggtaaaa gctgtgcatc tccccagtgc tcagggtttg tgacagttgg gagaaaggca 115560 ggggacacga agtcactgct ctccaaacct gccctgtcct tttcctactg tccgtctggt 115620 ttctgctcca ctcagcctct gtcccacttc tcaagtccct catgaaatga agcctcctgc 115680 tgtgcttagt gctgtgctgt gctcagtgct gggatgggtt catgttcctg cagaaattgt 115740 ggacaggtag tcaggtgagg agcagggagc actggggatg catgcacacc tggcaggaga 115800 gggtatgcca ggcatggctt ccgggagaag taaaatctca gctgagacag gcaaactgca 115860 taggtcgggt gaaaggggca gggagggaat gagcgttcca cacagaggca gggggtgtag 115920 aagcacaaag gagggggtcg tggtgaggag gtggagggct gagccggggc cgggtcatac 115980 ggggccttgg cagcagtgca aaggagcttg gaccacattc tttgtttcca ctcggaagtg 116040 aaatactgga ctgaatagtc tttgagactg atgtaggcca cactgattat tttacttgag 116100 atttttgtga ccatgagaat atcatctgcc aaatccctgt agtagtgggc taacaagata 116160 gtattctggt catgtgaaaa ccccagccca tttcccaaag gacttacttt gtctctgata 116220 agaggtttgg tgacaagttt gaaggctcca atgtatacaa gtgagaatag aaaagatatt 116280 ttcagcccta gaggtgttta tcaactggct aacatgacac cactgagagc attaaacagc 116340 ataaaaataa tgacaaagct gtgatcagca gctgcagatg gtttttgtac acattgacca 116400 tctagggtga gtaaagggga gttcagggaa ggcccacggg gcagaaggtg aggccaggga 116460 ttggcctaga ggggaagcaa aggcagaccc aataccaagg agctaatctt ttgctaagca 116520 acgtggtctg gaactggcgg cctgaagtgc ttgattacca gggatactgt tgcagatgac 116580 tggggaaagt cagatcctcc aagccgagcc acctgcaatt caaggtagaa tctggcagaa 116640 tacattcatt cctgtgtgaa aaattcgaat cagagttttc tctaactgct taccagataa 116700 actactactt ggctttcttt acttcttgcc ctttttcttg cttcttactt ccctcctttc 116760 ctcctctctc cttgtttcct tccttccttc atttccttgt tccttccttc tttccttgct 116820 tgctttcttc catccttcct tccctccttc ctttcctttc ttccttcctt ctccttaact 116880 ttataatttg gtaatgtctt ccttaaaaac ctgactttgg aacgatacta cactttctat 116940 tcagcaacga gtagtagttt tgcctcccta tgttattgtt gtgtttaaat cctggattct 117000 ttcctgctgt catactttgt catgagagtg aatcttgccg ggcgtggtgg ctcatgcctg 117060 taatttcagc actttgggag gctgaggtga gtggatcacc tgaggccagg aatttgagac 117120 cagcctgatg aaaccccatc tctactaaaa atacaaaaac tagcatggtg aaaccccgtc 117180 tgtactaaaa atacaaaaat tcgccaggca tggtggtgcg tgcctgtaat cccagctact 117240 cgggaggctg aggaaggaga atcacttgaa cctaggaggc gggaggttgc agtgagctga 117300 gatcatgcta ctgcactcca gcctggggga gacagtgaga ctgtctcaaa aaaaaaaaaa 117360 aaagagtgaa tctttgtgat tgtcctggag ggaatgtgca gagagaactt ggagagccag 117420 ttccatgggc tgttgattaa cctgacagaa acgacatcct gttcttgata ccttaataat 117480 ttatttgtat tagcatgtca ctttctccaa ctctattttc atagttggtt caggctgcca 117540 taataaaatt ccatagactg ggtggcttaa acgagagaca tttatttccc acagtttagg 117600 ggcaaggaaa gccctggcag gtttcatgtc tgatgagggg ccatttcctg gttcatagat 117660 ggcaccatat agctgtgtcc tcacgtggtg gaaggggcaa ggcagctctc tggggtctct 117720 tttacaaggg cactaatccc attcgtgagg gctccaccgt cctgatctaa tcacctgcca 117780 aggccctgcc tcctaatact attgcctcgg ggttcaggat tgcaacattt gaactttggg 117840 gtagggggcg gggaatggga cacaaacatt cagaccatag catctgtttt ctgatttgag 117900 aaactggcat aataacatct atgtatctac atggatgaat ttagcagggt cttgaaaaga 117960 ttcttcacac attagaaaat gttaagacat ggccaggcgc ggtggctcac gcctgtaatc 118020 ccagcacttt gggaggccaa ggcgggcgga tcacgaggtc aggagatcga gaccatcctg 118080 gctaacatgg tgaaaccccg tctctactaa aaatacaaaa aattagccgg gcatggtggt 118140 gggtgcctgt agtcccagct actcgggagg ctgaggcagg agaatggtgt gaacccagga 118200 ggtggagctt gcagtgagcc aagatagcgc cactgcactc cggcctgggt gaaagagcga 118260 gactccgtct caagaaaaaa aaagaaaatg ttaagacatg ttcctttttt tttttttaag 118320 atgaccattg ttggagattt ggcagagggt ggtcagttat tttagaaagg gctcaaatgg 118380 tgattgccat tacccactgt ctttaaaagc tgaatgatca aaatagtata catgaaaaga 118440 tttcaggaat tcataagttt tccggttttc cttgatggca ctttccagtc acctacccta 118500 catatgaaaa tgggagccta tttctgtttt cagattgcag agggaatggc atacatcgag 118560 cggaagaact acattcaccg ggacctgcga gcagctaatg ttctggtctc cgagtcactc 118620 atgtgcaaaa ttgcagattt tggccttgct agagtaattg aagataatga gtacacagca 118680 agggaaggta tgttgcacta atgatcttta gatgttttat tattgtgttt tattttgttt 118740 ttgtctgttt ttgacaaagc aattacaata gtcaccatta agaaaaactt atttggtaca 118800 acatttaagc tgtaccataa ttgtctgctt atggttctat tctaatagtt tctagaaggt 118860 actctcttga ttaactccac atgatacttt tgttaggctt acaaatgcta tcagttgtat 118920 ttcaattaag caatgcaaaa cacaaataga ttcagcaaga tgattcttgt ttattttgta 118980 ttgttaaagt tttcactcaa acaatgaata taatatacgg ggctgtggag aaaatatttg 119040 taacattaat tctatattgt ttattccagc cttttaatta caaattaaaa catgaacatt 119100 accatacaca cagaactaaa tataatgcaa aaaatctact tctttatttt cccacattct 119160 gtattatata tatgaaccaa aaatgcacag agaggcctaa gttccccagc ctgtggcaca 119220 ttgtcagggg gccaagcatg gtcgggactg cagggccttt cttgggctag gattgcccac 119280 gtggttatga ctgaggattc ttatgctctc acccacgaga gctgagcaaa tatttttgca 119340 gtgctcactg tcttctggaa gagacaagca ctttcttgaa attcctaagc attgttgaac 119400 aaggattatt attattttat tattttgaac ctgggaggtg aaggttgcag tgagccgaga 119460 tcgcatcatt acattccagc ctgggtgaca agagtgaaac tccgcctcaa aaaaagaaaa 119520 gaaaagaaag tatggggtca catgttcatg acttttttgt ttaagtttaa atacccaagt 119580 aagaaccaca tatcttcttc cttaggtgct aagttcccta ttaagtggac ggctccagaa 119640 gcaatcaact ttggatgttt cactattaag tctgatgtgt ggtcctttgg aatcctccta 119700 tacgaaattg tcacctatgg gaaaattccc tacccaggta tggtttactt agctatttac 119760 aatcaagctg tataaatgag aaaaagtcag gttgcatgaa ggcattaaaa agtaataatt 119820 acttcatcta cccgatagca aagaataagt gctttgagcc agaacttgat tttcacgggc 119880 tgggcatggt ggctcacgcc tgtaatccca gcactttggg aggccgaggc aggtggatca 119940 cctgaggtcg ggagttggag accagactga ccaacatgga gaaaccccgt ctctactaaa 120000 attacaaaat tagccaggca tggtgacgca tgcctgtaat cccagctact cgggaggctg 120060 agacaggaga attgcttgaa cccgggaggt ggaggttgca gtgagctgag atcgcgccat 120120 tccactccag cctacacgac agagtgagac tccatctcga aacaaaaaaa agacttgatt 120180 tttattttca ctatctttag cataaattgt tctaagagtg cttagacact tctttgcctc 120240 cttattttga gtgtgtgttc ttgttctgca ctgattaatt ccaccacata ctagaatgtt 120300 ccgggcatgg ttgttggtgt cgagatgagg atggatagac acaggggctc ctccaaggca 120360 gtccccctga ctggaaggag gaaacccaca tggagacaag gatttccgat gcttggtttt 120420 gtaataagtg ccctggagtc tctctctctt caagaaataa ccacctttgt ttatcagtgg 120480 gaggcccttc tgctctttaa catactggta tcagtgaggg catcattcag tatttatttc 120540 cagattccta acacctgaag cctgcagagc cagattctga ccatccctcc atttttccat 120600 ggtctgtgct ggcatggtta agaagaggga tttcggccag gtgcagtggc ttacacctgt 120660 aatcccagca ctttgggagg ctgaggtggg tgaatcacga ggtcaggagt tcgagaccag 120720 cctggccaac atggtgaaac cccgtcatta ctaaaaatac aaaaaattag ctgggcgtag 120780 tggtgggcat ctgtaatccc acctacttgg gaggctgagg caggagaatc acttcaacct 120840 gggaagcaca ggttgcagtg agccgagact gcacccctgc actctagcca tggcgacaga 120900 gtgagactct gtctcaaaaa aaaaaaaaaa aaaaaaaaaa aaagagggat ttctcccaga 120960 gccttcatat tttcatttat gtttgactat taacaaaata tttgcatgag gggaatttaa 121020 aattaaattt ttaatgttta aatctttctc ctattcaaaa aatatttgag tatgctaggc 121080 actctcagct gctaggatgc catggtatct gcccatgtcc ttgagagtga atattgtagt 121140 ggggagagac tgatgtttat caaacacaca gccatcctgt agggtggtga gagtagtgtg 121200 gagcctgcgt ggagtggctt agggattggc gagtactcac agaagggggt ggggagctgc 121260 tggttttatt ccatggtcct ggcagcagca gggactcaca gagggaggga gtcttgggct 121320 ctctgaggtc tgcatgtccc catggggaga gcagccagag catgggcttg gccaacagga 121380 gcaggaggcc agcgtggttt gggcctctgt gagtatttga tggatggatg ggtgaatgaa 121440 tgaatgaatg aatgacgcac ctaggccatt tgatctctag acagtcgatg gatgagaaag 121500 aaggctatgt agctgggggt tagagtggct cagggagaga cttactggcc atgtaagagc 121560 agcccctctt actctgctga gatgcaaacc agggaaggct tttggacaga gcagccacac 121620 agtctgcgtg ctcccatcac tactgtttca tgtggggatg agccacagag aaactggggc 121680 agggaccagt tggcagctga aagcctttgg gtggtgtctg cctgcacagt ggaccggctg 121740 tcccaggaaa tccctttagt gccagcattt catcttccag ctgctctaga cactgagatt 121800 aatgaattaa cattgctgca aaataggaaa aatatttcta atcagcccca gtgtctgatg 121860 ttatatatct ctatctccat ctatgcctac atctctttct ataatctgtc tgtagagaaa 121920 gattatatag tcagattatg tatataatct gacacctgat aaacatacaa tctcataaaa 121980 gaatgttttg tgatatgcgt ggtgtgctgc atgtgatgtg ctaccatggc ccctgaggct 122040 tggagaaggt gattgggccc ctcgctggtg gcaaagctgc tctgagcccc agatccatgt 122100 gcctcccaag acccctcagc caatgtgcac aatgcccagg atttggaaat atttggggtg 122160 aaaaatcatt ttttgaaaaa agaactggct gggcacggca gctcacacgt gtaatcctag 122220 cactttggga ggctgaggca ggtggatcac ctgaggtcag gagttcgaga ccagcctggc 122280 caacatggca aaaccccatc tctactaaaa atataaaaat taggctgggt gcagtggctc 122340 acacctgtaa tcccagcact ttgggaggcc cactttgtgg gcggatcaca aggtcaggag 122400 atcaagacca tcctggctaa tatggtgaaa ccccatctct actaaaaata aaaacaatta 122460 gccaggcgtg gtggcaggcg cctgtagtcc cagctactcg ggaggctggg gcaggagaat 122520 ggcatgaacc tgggaggcgg agcttgcagt gagctgagat cgcgccactg caatccagcc 122580 tgggtgacag agcgagactc catcttaaaa aaataaaaaa aaaaagaata aaataaaata 122640 aaaataaaaa gtagccaggt gtggtggtgc acgcctgtaa tccggaggct gaggaaggag 122700 aatcgcttga acccaggagg tagaggttgc agtgagccaa gattgcacca ctgcagtcta 122760 gcctgagcga caggaaggag actccatctc aaaaattaaa ttaaattaaa ttaaattaaa 122820 ttaaattaaa ttaaattaaa aaataaaaag agaaccagta gaaaaatggt gagaatcata 122880 aaaatatgtt tctctctata tggaagaaca caccagaatc catcgactag tctgttccct 122940 gattggcttg tccctggaag gactggggat gtgagatatc ttcaggagat cgggatcagt 123000 aaatttttta gtcacgagag ttgtatgtta cgagagcctc tagcattagg gttataaaca 123060 taatcaagca atcctattta cttcacatga gaagacttga ttcatagcac agaaatcggt 123120 aaacattgcc aaaatatgcc attttccaca cggttataaa actgcatatg ggagagaatc 123180 cacgatgaat ggaattatct gaaagtactt tctttacgca gtaaactgct ggctatgttt 123240 ttgttttttg tttttttttt tttttgagac agaatctcgc tctgttgccc aggctggagt 123300 gcagtggcgt gatctcggct cactgctagc cccacctccc gggttcacgc cgttctcttg 123360 cctcagcctc ccaagtagct gggactacag gtgcccgcca ccacgcccag ctaatttttt 123420 ttttattttt actagagaca gggttttgcc gtgttagcca gaatggtctc gatctcctga 123480 ccttgggatc ctcccgcctt ggcctgccaa agtgcttgga ttacaggcac gagccacctc 123540 actcgacctg tgttgttcgt ttttaaagta ctttagaagc tatacaggcc aggtgtggtg 123600 gctcatgcct gtaatcccaa cttgggtgga tcacttgagg ccaggagttc gagaccagcc 123660 tggacaacat ggccaaaccc tgtctctaca aaaaatacaa aaaaaattag cccggcgtgg 123720 tggccaacgc ctgtaatcct agctacttga gaggctgagg cagagaatcg cttgaatgct 123780 tgaacccagg agacagaagt tgcagtgagc cgagatgcgc cactgcactc cagcctgagc 123840 tacaaagcga gactctgtct caaaaaaaaa aaaagaagaa gtcatatcat atacttagct 123900 ttgtaaaata aaaaggaaat aaaagaaagg aggaaaaaga aaaaagaaag tcacatataa 123960 ggcaaactca tttttagagg agatagaaat actaagataa tatactgaaa tgttagcatt 124020 gggtcaagag ataataggtt atattaattt tcttcttgat gaatttctga aatttctaat 124080 ttttttacaa tgatattgtt attaaatatt ttattctttt tttttttttt tttttttgag 124140 atggagtttc actcttgttg cccaggctgg agtgcaatgg cgccatctca cctcactgca 124200 acctcctcct tctgagttca agcgattctc ctgcctcacc ctccctagta gctgggatta 124260 caggcatgtg ccaccatgcc cagctaattt tgtattttta gtagagatgg ggtttctcca 124320 tgttggtcag gctgatcttg aactcccgac ctcaggtgat ctgcctgctt tggcctccca 124380 aagtgctggg attacaggtg tgagtcaccg cacccggcct aaatatttta ttcttatcta 124440 agtaatatat gcacattaaa aaagtagtac agaaagactt cctttttttt tttttttttg 124500 agacagagtc tcgctccgtc acccaggcta gagtgcagtg gtgtgatatc ggctcactgc 124560 aacctccacc tcccaggttc aagcaatgct cctgcctcag cctcctgagt tgctgggact 124620 acaggtgtgc accacaatgc ccagctaatt tttgtatttt tagtagagac ggggtttcac 124680 catgttggcc aggctggtct tgaactcctg acctcaggtg atccacccac ctcagcctcc 124740 caaagtgcag ggattacagg catgagccac cgtgtgcagc cacaaaaaga cttccaatga 124800 aaaattcccc atgcctgcgg gtgctcctca aagtaatcta cttttgggaa ttttgattcc 124860 ttattctagc gtttgctgca tatagttcta aatattctac tcataacttt tatctcttaa 124920 ttaagttttt tccacttatt attagataag gatatggcca catactttta tttttcattt 124980 atttatttat ttgacagggt cttgctctgt cacctgggct ggagtgcagt agcatgatca 125040 tagctcactg tagcctttaa ttcctgggct caagtgatcc tctcgcctca gcctcctgag 125100 tagctaggac tacaggcgca tgccaccaca cccagctaat ttataaattt tttgtagaga 125160 cagggtctca ctatgttgcc taggctggtt tctaactcct gggtcaactg atcctccctc 125220 ctcaacctcc caaagtgctg gaattatagg tgtgagccac cacgcccggc cagccacatg 125280 gtgttaaatt caagagatac aaagaggtgt aagctgaaag gtcccccact ctattcccag 125340 ccacacaatt ctctccccat aggcaaccag tgttctcagt ctctacttta gagacatcct 125400 ataaggggag tcatacagtt ttgccctaat gtctggttta tttcactcag cataaccctc 125460 aaggtccatg catggtgtgg cccatgtctt cagtctttct tctcactcct ggtcttccat 125520 accacacttt ccccacctcc acttgggcct agcattccct gcatgaagct tctccattgt 125580 ttcttccagc atttgcctgg gcactggtac tatgggctcc aggtactgtc ctgccctcgg 125640 cgctggcctc cctccctcat ggtatatgct gaccacacag tgtgtgcctt cctgggctga 125700 gttgggatgg gccgccttgc ccgttgtcag tgcccctctc tgcaggcacg ttggttgcac 125760 tttcttcctc ttggctcaga ccacttcttc ctctggctgc cagatgtctc ttagcatcat 125820 cagagatgga gtttaagttt ctatttcttg ttctcttttt tgttttggga tgaattacag 125880 aaaaaagaaa atagtgagga ggaggcaaaa gatctttact tcattatctt aaaaccaaaa 125940 ctatgattat atttctctat caattttata cagaaaaaaa gaggggtctg actgggcatg 126000 gtagctcatg cctgtaatcc cagcactttg ggaggccgag gcaggtggat tgcttgaggc 126060 caggaatttg agaccagcct gggcaacata gcaaaaccct gcctctacaa aataatttaa 126120 aaattaccag agtatggtgg tacgcacctg tagtctcagc aactcaggag gctaaggtgg 126180 gaggatcacc gagcccaggg agtttgaggc tgcagtgagc catgattgcg ccatgtactc 126240 cagcctgggc aacagagtga gaccctgtct caaaaaaaag gtgggggtgt cttgttgggg 126300 tcctggttgg ggtcttgttt tgctttgttt atataaagca aaaggtttga aagtgaaaaa 126360 attttctgaa gcatcatgac ttttctggct gtttctgacc agatatatct aacatcttaa 126420 tgccagctga attagaatca agaaatttgt cctgctgcaa acaaacactc accttggtca 126480 caagcaaagc tcagaaaata ataatagtaa taataatttg cccttttgga aggagtatga 126540 ttgggtggga gactgtactc ccagggtatc tagctcttcc tgatacacat acacacaaag 126600 ggccctgtgt gactgaagac tgtcatagtt tgtggtacag ctgtgctcct ccctgtcact 126660 agctatctgt tccttttctc tactgtacca catttttctc cttcttctgc ttctttacca 126720 acttgtagtc tctgctgatt tctacccact ccagatgcca ccttctgctc cccaccacct 126780 ccttctggtg agggcattgt cctgactggg ctgtgtgcca tttgaggatg atgctctgtc 126840 ttaactatct ctgcatgtct cagagctcag tgctagttca tgacccatag tgagcactca 126900 gtgtttgttg aaaggaggaa ggatggaaag tgaaactgtg tgccttctaa gcagatcacc 126960 agctaatggg tgtttacttt ctttaactta gcgacaggcc aacaccaact atcacatgta 127020 atcttagggt ctggttgagg tccctctcct cttcttattt ctttctttca caagacttgt 127080 catttaatag cggattttat ttattgcttt ccttgtacat aaaaagatag gcttcagatt 127140 cccttcttcc aattcttctt atcaagtcga attccccaaa cagggtggag catgtccagc 127200 ctttaccagc atcatcgaga gtccttcaga gctaggagaa catactggaa ccaggaaaaa 127260 aaaatctgct gtggggctag ggtgacctag aaagctttat cttccactgt ggctgcattc 127320 tgacctttta tgcaaatgag ggatctccag gaaggaagtg aaagagatat tccaaactga 127380 gtgtgcaggt ccaattgcta tttatatcat actggatgtt agtcctccca ccacgatccc 127440 agaatttcac ccaagaaagc agaagtatac acaaatcttt cttctgaaat ttatccaagt 127500 tataagagcc agagcaatgc tgaggccata tcattttgtg gagactaaaa ctcccaaata 127560 aagaggatga tacaaatctg tctttcgctt taagcaatga aaatcaaatg aagtatttta 127620 gttagaaaat tctagtcaca caaatatttg aagatagtgt ttcagaatta gactcaggaa 127680 aatggatttg ctgtataaat tctcaagaga tctgaatcat tataaagttt gcttagatct 127740 ttcaatttca aaaacaaggg ctcttccacg acagaaatga tcatgtcttc tttcagcggt 127800 ttaaattcag gaaaggtcac tgtgtcctta gatgaaaaaa ggtaagttaa aggcagagga 127860 tctcaaagtt tattggccat aagccattgt gggaaataca tagaaaccta ctctgtacat 127920 aaagcaaacg tttcataaaa ccatattgac ctttcctatg tgcagtgctt tctgaccttt 127980 tctgttttat tctgttataa ttcattttaa aaaatactgg taattggctg gatgcagtgg 128040 ctcccgcttt taatccagca ctttgggagg ccgagacagg cagacgactt caggtcagga 128100 gtttgagacc agcctggcca acatggtgaa accccgtctc tactaaaaat acaaaaatta 128160 gccgggcatg gtagtgggca cctgtaatcc cagctacttg ggaggctgag gcaggagaat 128220 cgcttgaacc tgggaggcgg aggttgcagt gagccaagat cgctccactg cactccagcc 128280 taggtgaaag agggagactc tgcctcaaaa aaaaaataaa ataaaataaa ataaaataaa 128340 atactggtag tactctaaaa aagtcaattt gttgatccca aattgttgat cccaaatgcg 128400 gatagtgccc cgcaatttga aaaacactga ttagaaaata cattcaaaag aaggttctgt 128460 ttcaaatctg gtaaaaagcc atttcccctg aagctgccac ttatttagaa tccttccagt 128520 gaccagtgat ggtataatct acagctttga aaaagagata gctatggaaa ggaaattcgt 128580 tgtgaggaat ggagcccctc tcatatgcca gatattgtat atactttgca tgacatacat 128640 tcttctctag agaagttcac atcctacaga acagggtatc catgaaatat gcaaaacata 128700 caggtgtgga tagatactgc tagatgagca cataattgaa ggattaatct cctttatcat 128760 gcaggaaaat gttattatta taatgatctt ttttaccctt taaagctatt ctcaggatca 128820 aagattgaca gttcagcttc tgaattaccc tgagacattt gaccacatta aaaacattct 128880 ctattaccag gccttttgca gagctctaga ggagtaatga gcaccttact tctctcctgg 128940 aggtcaggaa tatgcaaatc cagagtcaga gtgagctgtc actctggcca ggtactgcag 129000 attggaacag ttaactgcgt ctgtgaagta gctccacttg agactatgat tggggttcag 129060 ttttcctcct caattaatat cttgctctta aaagacagtg acatccacaa gatatgtagc 129120 acaaactaca gacaagtgtc cttcagatta actgaaccat cattattttc caaattaatc 129180 cctaagtttt taactatttg gcaagcatgt aaccaatttg ttgggctgac ttaagggtgc 129240 tgactttaag taaatgaaaa taccaattat taaatgaaaa gccaattttt gaaaaatgtc 129300 cgtataagat aatatgtggt aaaattattt ttttcataaa tatactacaa gttgaagctg 129360 aaagcatgct accctgcaaa cataattaaa gttgagagtt aggattagat ttgggtgatt 129420 tatttgaaat gtgaggcaag tccaatatcc ttttgttatt aaagagaact tggctgtggc 129480 tcctacttaa caaattttgg caaactgaat gctgtcttga tcccctccat gctaaattta 129540 tttattgagt tgcttgcaga aatttcctta gcttctatat tagttggcaa gggctgccat 129600 aacaatacaa cacactgggt aatttaaaca acagacgttt atttttccgg ggttctggag 129660 tttcaaagtc caaggtcaag gtgctagcca ggttgatttc tcctgaggcc tctctcctgg 129720 acttgtagat ggctgcctcc tccctgtgtc ttcacatggt ctttccccta tactagtctg 129780 tgttctaatc tcctcttata aggatactag tcatattgga ttaagaccta cccaaatggc 129840 ctcattttaa cttagttacc tctataaagg ccttatctct aaatatggtg ctgtcaattc 129900 tgaggtgtac gcggggttag gacttcaacc taggaatttt gggaggatgc tgttcaaccc 129960 ctaacagcct cagtaaagct tgtttcaatc atggttacag gatgtgagga gcaaaaagac 130020 cactgcagtg cttgaccctc tgccaggttt ctaaacggca tgggtttctg ttctttttgt 130080 ttttttccac cctagggaga actaatgccg acgtgatgac cgccctgtcc cagggctaca 130140 ggatgccccg tgtggagaac tgcccagatg agctctatga cattatgaaa atgtgctgga 130200 aagaaaaggc agaagagaga ccaacgtttg actacttaca gagcgtcctg gatgatttct 130260 acacagccac ggaagggcaa taccagcagc agccttagag cacagggaga cccgtccatt 130320 tggcaggggt ggctgcctca tttagagagg aaaagtaacc atcactggtt gcacttatga 130380 tttcatgtgc ggggatcatc tgccgtgcct ggatcctgaa atagaggcta aattactcag 130440 gaagaacacc ctctaaatgg gaaagtattc tgtactctta gatggattct ccactcagtt 130500 gcaacttgga cttgtcctca gcagctggta atcttgctct gcttgacaac atctgagtgc 130560 agccgtttga gaagaaaaca tctattctct ccaaaaatgc acccaactag ctctatgttt 130620 acaaatggac ataggactca aagtttcaga gaccattgca atgaatcccc aataattgca 130680 gaactaaact catttataaa gctaaaataa ccggatatat acatagcatg acatttcttt 130740 gtgctttggc ttacttgttt aaaaaaaaaa aaaaactaat ccaacctgtt agattttgca 130800 ggtgaagtca gcagcttaaa aatgtctttc ccagatttca atgatttttt tccccctacc 130860 tcccaaaatc tgagactgtt aaaacatttt tcttctatga acactgctca gacctgctag 130920 acatgccata ggagtggcgt gcacatctct ctctcttcca gcaggaggag cccgtgagca 130980 cgcacagctg ccctgtctgc tcacccgaag gcaccgggct cacctggacc tcccaggaaa 131040 gggagaagag cctcagaaac tgctctgtgt ttagaaggaa tatttttaag agtccagctt 131100 tttcatttcc acaatttcct atatccagat ttgttttgac aatgtagttt ggaagaacta 131160 agattctaat ctctgaagaa ccttataggg ccttctaaaa cataagagtt tcctttgttg 131220 cttcaaatat ttgaacatta tgttaaagat caagtattaa ttttagttgt actctagaaa 131280 gctaaagtgc cacattcggg gctattttta tgattcagca atcttttcta aattgtgtag 131340 catgtgtatg agactattta tacccaagga tatgaaggaa cataagtgac tacaaggctc 131400 taataagcca cggtggcagg aggttcaagc ggttctgttc actaaatttt tctcctgtaa 131460 gctttgaatg gaaacttctg tatcacatga tgtgtttcac ttatgctgtt gtgtatatac 131520 ctaatatttc tatttttgat tttattttaa tacacctcgt ccaataaca 131569 <210> 35 <211> 7759 <212> DNA <213> homo sapiens <400> 35 aaaaagtgct ttattttccc actccccgga cgcccagcag ggcagtttct tgaccttcgg 60 agcccctttc ccgaggatcc gctcgggagc ctcccctggc caggagcagg ggattagtct 120 gccccgcgac cggccccagc cacgacgcgg acatcgcccc ctctgtctgg gccgctgtca 180 ctcacgcgcc aaagggccac ggagaaagaa ggggcgggcc ggggcgggcc gggcgagcgg 240 aggcggggac ttgcgccgtc ctgaggctgc ctcctagggt ccggccggcg ctggagctgc 300 ggatttagat tgtcactgcc acctcggtcg gtgcttactt cgctgccagc tggtcgtcgc 360 catgaacccg gacctgcgca gggagcggga ttccgccagc ttcaacccgg agctgcttac 420 acacatcctg gacggcagcc ccgagaaaac ccggcgccgc cgagagatcg gtgagggcgg 480 cgggcgagac ctccctcctt tcccgagaaa agctggagac tccctcgatg cggagtcagg 540 ggcgctgtgg ggcctaggcc ctctggccca gcgttagggg agccgggacc cccacttcga 600 ggaacagcct gtgtccctgg tggggggata tcgccattcc ccagagaaca tgatcctgaa 660 cgacccagac ttccagcatg aggacttgaa cttcctcact cgcagccagc gttatgaggt 720 ggctgtcagg aaaagtgcca tcatggtgaa gaagatgagg gagtttggca tcgctgaccc 780 tgatgaaatt atgtggttta aaaattttgt gcaccgaggg cggcctgagc ctctggatct 840 tcacttgggc atgttcctgc ccaccttgct tcaccaggca actgcggagc agcaggagcg 900 cttcttcatg cccgcctgga acttggagat cattggcact tatgcccaga cagagatggg 960 tcatggaact caccttcgag gcttggaaac cacagccacg tatgaccctg aaacccagga 1020 gttcattctc aacagtccta ctgtgacctc cattaaatgg tggcctggtg ggcttggaaa 1080 gacttcaaat catgcaatag ttcttgccca gctcatcact aaggggaaat gctatggatt 1140 acatgccttt atcgtaccta ttcgtgaaat cgggacccat aagcctttgc caggaattac 1200 cgttggtgac atcggcccca aatttggtta tgatgagata gacaatggct acctcaaaat 1260 ggacaaccat cgtattccca gagaaaacat gctgatgaag tatgcccagg tgaagcctga 1320 tggcacatac gtgaaaccgc tgagtaacaa gctgacttac gggaccatgg tgtttgtcag 1380 gtccttcctt gtgggagaag ctgctcgggc tctgtctaag gcgtgcacca ttgccatccg 1440 atacagcgct gtgaggcacc agtctgaaat caagccaggt gaaccagaac cacagatttt 1500 ggattttcaa acccagcagt ataaactctt tccactcctg gccactgcct atgccttcca 1560 gtttgtgggc gcatacatga aggagaccta tcaccggatt aacgaaggca ttggtcaagg 1620 ggacctgagt gaactgcctg agcttcatgc cctcaccgct ggactgaagg ctttcacctc 1680 ctggactgca aacactggca ttgaagcatg tcggatggct tgtggtgggc atggctattc 1740 tcattgcagt ggtcttccaa atatttatgt caatttcacc ccaagctgta cctttgaggg 1800 agaaaacact gtcatgatgc tccagacggc taggttcctg atgaaaagtt atgatcaggt 1860 gcactcagga aagttggtgt gtggcatggt gtcctatttg aacgacctgc ccagtcagcg 1920 catccagcca cagcaggtag cagtctggcc aaccatggtg gatatcaaca gccccgaaag 1980 cctaaccgaa gcatataaac tccgtgcagc cagattagta gaaattgctg caaaaaacct 2040 tcaaaaagaa gtgattcaca gaaaaagcaa ggaggtagct tggaacctaa cttctgttga 2100 ccttgttcga gcaagtgagg cacattgcca ctatgtggta gttaagctct tttcagaaaa 2160 actcctcaaa attcaagata aagccattca agctgtctta aggagtttat gtctgctgta 2220 ttctctgtat ggaatcagtc agaacgcggg ggatttcctt caggggagca tcatgacaga 2280 gcctcagatt acacaagtaa accagcgtgt aaaggagtta ctcactctga ttcgctcaga 2340 tgctgttgct ttggttgatg catttgattt tcaggatgtg acacttggct ctgtgcttgg 2400 ccgctatgat gggaatgtgt atgaaaactt gtttgagtgg gctaagaact ccccactgaa 2460 caaagcagag gtccacgaat cttacaagca cctgaagtca ctgcagtcca agctctgaag 2520 tgtcacaagg acaagtttaa tctgcttcag aaagcgcctg tgtgcaactc aaattttgtg 2580 gaatcttttt cgaattcaaa tagctataga gcaaatgata aattgacccc tttttataaa 2640 tggagggaaa aaatgaacag atttcagaga ttaaatgaaa aaaagcagat gttttaagtg 2700 caattaacac tgaaagagac ctgttaaacc attcagaaaa agcttaagaa atgcgatatg 2760 acttcctttt gtaatgctgc tgatcccagt agactatgac ttttgataat tagcagaatt 2820 taactactga gtagttgatt attttcacat tttaattgct aatcactggc tatataagtg 2880 tttttaagca aaggtatttt tgaagtggtg tagaaccctt ccaagctttc ctgctcagtg 2940 ttctaccaga cttaccctgg ggcctggctt aaaagcagga ttgaagaaaa gggactgggg 3000 gaaggaaact tattggaaaa cttgatgcga atgagtttct gcttggcaca gtctctgcct 3060 gcttgctctc ctttgctgat ggattgcatt tatcaaacta ttcatgctag catttttcca 3120 acgagggaac ttattccgca cgggcctact gtaggaccat tgtctcgtgt aattaggaat 3180 tttccatttg aaggattgct aaattgtcac agtagtagga agtataggga aacctctcag 3240 ctgtggcact gttgtagctt tggagtgcag agtgtaactc tgggacaatc agatttcaca 3300 tattctgtca tcttggcata agccattaaa agcttggaga ttactgtatt tggcattaaa 3360 aaaaaatgtc acttaggtca gcactcccag acgtagcaca gaaaaaccct ttgacacaaa 3420 ccatgtgttc tgatttttgg ttcagaaaat attgaaactg tgagttgttt tttttttaac 3480 aactgggaaa aaacaaaaac aaaaaactat agttagaaaa atggaagttc cataggttct 3540 atttcttact ctatgtatgg ctttgttttc agtctatttc taggagcttt ctctgaatcg 3600 ctaattgtcc tttcagttga aatctaattt atacaatcat tctatactta aaggttaaat 3660 acatcttaat taattttttc ttaaagtcaa tgtaagtcac tttgttttgt ttttttttaa 3720 tctacgccat atgcctcatg aaaccagctg ttctagaatc agtcctgaga atatggctta 3780 attccatgga aacataactc ctatcttggg acctgacata atatctatct atcctgggga 3840 actggtaata tgagacttat aggttacagc agaaatgcta catgttgaca aaagccttaa 3900 tcgttccact gggagaacta attgataatt gtgttaagat tgaagattaa ccctgtgtta 3960 atctcacttg agtctatcct gacagtagtt cagattctgg aaaatgataa actgacctgc 4020 tagatgtaga attgtttcaa aattagtgtt gaaatacctt gttcacagat gaatatctgg 4080 gcaggatctg agggtgtttg gaatgacacc ccccaatcca gttgcataga tgggatgtct 4140 ttgcaggttt gaggagatca tcgacctgca gagccccctt tgacccagta cctcacgttt 4200 tatttaaaat ctaaatctgg ggccaggcgt ggtggctcac gcctgtaatc caagcacttt 4260 gggaggccga agcgggtgga tcacctgagg tcaggagttt gagaccatcc tggccaacat 4320 ggtgaaaccc cgtctctact gaaaaaaata caaaaattag ctgggcatgg tggtagcacg 4380 cgcctgtagt cccagctact cgggaggctg aggcaggata atcgcttgaa cttggcgggt 4440 agaggttgca gtgagccaag atggtgccac tacactgcag cctgggtggc tgagcgagac 4500 tccgtctcaa aaaaaaaatc taaatctgac atttgatgct atttttatta atattggaat 4560 gttctgtctt gaactttatt caatataatc aagaataaag atagagtaaa cgtcactgat 4620 ttgtactatt aagagagaaa aaatatgcca cacaactaaa cataggttta aattatgaag 4680 aaatttagaa tagaggttta ttagatttag ggaacactaa gaacaaaaaa ggaaggagtg 4740 atacctgcct gagtggacag ctgtaaatca gctgtaatta ctgcagttgt accaatagtt 4800 gtgagtggct ccagtcactt taggagtcct tggaagtact tggtacacat ttgttggctg 4860 taccttaaag gaagtggcaa gtccagtttg ttctctctac cacactagac tgccactgac 4920 aagtttgggt ctgttggatt caaaattttg taagccattt tcacaagtac aaagatacat 4980 tttaaccttg tcttctccaa aattactgag taggaatttt atttttatct ttttgagaca 5040 gggtatcact gtcacccaga ctggagtgca gtggtgggat cttggcttac tgtgacctct 5100 gcctcccggg ttcaaatggt cctccctcct cagtctcctg agtagctggg acgacaggca 5160 cgtgccacca tgcccagcta atttgttcta ttttttctgt agagacgggg ttttgccatg 5220 ttgcccaggc tggtctcaga ctcctgggct caagcgatca tttcgcctca gcctcccaaa 5280 gtgctgagat tataggtgtg agccacagca tctggcccag agtgaggaga attaatgaga 5340 ttttttgtgt gtgttagata atattgattt aagccttttt ttaaaaagta ctctcaacca 5400 aatacaaaat tgaaaatgtg aggtttaata gaaatgtgtt ggctatttgc aatggatttt 5460 cttcttgccc aagtgtttgg agttctactt tatgctctgt atttaaaaat tagtgacctc 5520 aaagcagagt tgatgacaca ggctttgggg ccctcatgtt cttgtcttta gaacatatca 5580 ctactaagta tcagcttatc ttcagaacat tacaacattc accgtgttca tatgctttct 5640 gagaagtcac cacttgtaat ttcagatcac atacacctga aggcatttta tagttcctaa 5700 agttaacatg ttagatcttt tttttccacc ccatgagggt ctcactctca cccaggctgg 5760 aatgcagtgg tgtgattgta gcacactttg gccaccaact cctgggctca agtgatcctc 5820 ctgctttggc ctcctctgag aagctgggat tactggtgca caccaccaca cctggctaat 5880 tttttatttt tttttatttt tggaaatagg gtatggctat gttgccttgg gcccgtcatg 5940 aactcctagc ctcaggtgac cctcccacct caggcctccc aaagggttgg gattacagga 6000 gtgagctact gcactgggcc aacatgttaa tttttttttt tttttttttg agatggagtc 6060 tcccaggcgg gaatgcaatg gtgcgatctc gacttcactg caatcttcac ctcccgggtt 6120 cgagcgattc tcccacctca gcctcctgag tagctgggat tacaggcacc tgccatcacg 6180 ctcggctaat ttttgtattt tgagcagaga tggagtttca ccatgttggc caggtgatct 6240 gcactcccac tccccccaca cttcccaaag tgctgggatt acaggcataa gccacaagcc 6300 acctcaccca gccaacatgt tacatcttaa ttcttggatt ttcttcactg cagggctttg 6360 ggtggagaaa taaaactctt caaatgcatg atcttggaga tccctgtgaa tcaataattc 6420 tttagacaac tgcggctcaa aatccctcct ttcccttttc cgagttattc catccatctt 6480 attagaaagg aagtgaatta ggtgtaggtg gtctgtaaca cctgcacatc tttttatacg 6540 tgtagagggt atgcctggga tatataggtt gtcttcaagc agtagctgct actacagcta 6600 gagagaggag gagtgccagg aaactgatga cctgagacca agagtcttgt tgatgttctg 6660 acttagataa aggttttgat cattttcatg aaataatgca gggaagtcat ttctgctgtt 6720 tctttactac tccattcttg gaggattaga acaagtcaca ctgtaattga ctaaaacgac 6780 tttttatttt aaaatattga tggtggggtt ttgctttttt tttttttttt ttttttgaga 6840 cgttgtcttg ctctttcacc cagggtagag tgcagtggcg aaatcttggc tcactgcaac 6900 ctctgcctcc cgggttcaag caattctctg cctcagcctc ctgagaagct gggattacag 6960 cgcctgccac catgcctgtc tagttttttt gtatttttag tagagacagg ggtttcacca 7020 agttggccag gctggtcttg aactcctgac ctcgtgatcc acccacctcg gcctcccaaa 7080 gtgctgggat tacaggcgtg agccaccgtg ccgggccagt gtttttaact gtccacactt 7140 actaaatttt ccagtacttc ttcctatggt tcatgatagt aaacacagaa acatataagg 7200 aacattatta gagttaccag atgttagctg ttgcatatgt gcacattcct agattcaagg 7260 gtgtttttgc cttaaattta agtgggtcat tggttgtctt gggaagatca tggaaaattc 7320 gggatttttt agaattctga accaaaatat gttttgagtg tttcttagta aatgtgtgat 7380 cttccacctt ccacattcag actgcggact acacttcata aatgcctttt tatttccagt 7440 tatggattca actaaatgac tgccttggga gcacataatt actttgctac ctttttcccc 7500 ctttgctgtt gtggctcgag tttggttctc acctgagaag atgcattgag catatgttgt 7560 tacccagccc tggcttaatg gtgtcctgtg gggtaggggt gggaggacga ggggcacggg 7620 gccagagcat gtgaatggat catggttgga cagctgtgac ctgccagcac tgcgggtaag 7680 caaaactaca aaccgttctt tcctctgtga cattgaataa accttaataa aattcataat 7740 tagcacatac tagaaaaaa 7759 <210> 36 <211> 7585 <212> DNA <213> homo sapiens <400> 36 aaaaagtgct ttattttccc actccccgga cgcccagcag ggcagtttct tgaccttcgg 60 agcccctttc ccgaggatcc gctcgggagc ctcccctggc caggagcagg ggattagtct 120 gccccgcgac cggccccagc cacgacgcgg acatcgcccc ctctgtctgg gccgctgtca 180 ctcacgcgcc aaagggccac ggagaaagaa ggggcgggcc ggggcgggcc gggcgagcgg 240 aggcggggac ttgcgccgtc ctgaggctgc ctcctagggt ccggccggcg ctggagctgc 300 ggatttagat tgtcactgcc acctcggtcg gtgcttactt cgctgccagc tggtcgtcgc 360 catgaacccg gacctgcgca gggagcggga ttccgccagc ttcaacccgg agctgcttac 420 acacatcctg gacggcagcc ccgagaaaac ccggcgccgc cgagagatcg agaacatgat 480 cctgaacgac ccagacttcc agcatgagga cttgaacttc ctcactcgca gccagcgtta 540 tgaggtggct gtcaggaaaa gtgccatcat ggtgaagaag atgagggagt ttggcatcgc 600 tgaccctgat gaaattatgt ggtttaaaaa ttttgtgcac cgagggcggc ctgagcctct 660 ggatcttcac ttgggcatgt tcctgcccac cttgcttcac caggcaactg cggagcagca 720 ggagcgcttc ttcatgcccg cctggaactt ggagatcatt ggcacttatg cccagacaga 780 gatgggtcat ggaactcacc ttcgaggctt ggaaaccaca gccacgtatg accctgaaac 840 ccaggagttc attctcaaca gtcctactgt gacctccatt aaatggtggc ctggtgggct 900 tggaaagact tcaaatcatg caatagttct tgcccagctc atcactaagg ggaaatgcta 960 tggattacat gcctttatcg tacctattcg tgaaatcggg acccataagc ctttgccagg 1020 aattaccgtt ggtgacatcg gccccaaatt tggttatgat gagatagaca atggctacct 1080 caaaatggac aaccatcgta ttcccagaga aaacatgctg atgaagtatg cccaggtgaa 1140 gcctgatggc acatacgtga aaccgctgag taacaagctg acttacggga ccatggtgtt 1200 tgtcaggtcc ttccttgtgg gagaagctgc tcgggctctg tctaaggcgt gcaccattgc 1260 catccgatac agcgctgtga ggcaccagtc tgaaatcaag ccaggtgaac cagaaccaca 1320 gattttggat tttcaaaccc agcagtataa actctttcca ctcctggcca ctgcctatgc 1380 cttccagttt gtgggcgcat acatgaagga gacctatcac cggattaacg aaggcattgg 1440 tcaaggggac ctgagtgaac tgcctgagct tcatgccctc accgctggac tgaaggcttt 1500 cacctcctgg actgcaaaca ctggcattga agcatgtcgg atggcttgtg gtgggcatgg 1560 ctattctcat tgcagtggtc ttccaaatat ttatgtcaat ttcaccccaa gctgtacctt 1620 tgagggagaa aacactgtca tgatgctcca gacggctagg ttcctgatga aaagttatga 1680 tcaggtgcac tcaggaaagt tggtgtgtgg catggtgtcc tatttgaacg acctgcccag 1740 tcagcgcatc cagccacagc aggtagcagt ctggccaacc atggtggata tcaacagccc 1800 cgaaagccta accgaagcat ataaactccg tgcagccaga ttagtagaaa ttgctgcaaa 1860 aaaccttcaa aaagaagtga ttcacagaaa aagcaaggag gtagcttgga acctaacttc 1920 tgttgacctt gttcgagcaa gtgaggcaca ttgccactat gtggtagtta agctcttttc 1980 agaaaaactc ctcaaaattc aagataaagc cattcaagct gtcttaagga gtttatgtct 2040 gctgtattct ctgtatggaa tcagtcagaa cgcgggggat ttccttcagg ggagcatcat 2100 gacagagcct cagattacac aagtaaacca gcgtgtaaag gagttactca ctctgattcg 2160 ctcagatgct gttgctttgg ttgatgcatt tgattttcag gatgtgacac ttggctctgt 2220 gcttggccgc tatgatggga atgtgtatga aaacttgttt gagtgggcta agaactcccc 2280 actgaacaaa gcagaggtcc acgaatctta caagcacctg aagtcactgc agtccaagct 2340 ctgaagtgtc acaaggacaa gtttaatctg cttcagaaag cgcctgtgtg caactcaaat 2400 tttgtggaat ctttttcgaa ttcaaatagc tatagagcaa atgataaatt gacccctttt 2460 tataaatgga gggaaaaaat gaacagattt cagagattaa atgaaaaaaa gcagatgttt 2520 taagtgcaat taacactgaa agagacctgt taaaccattc agaaaaagct taagaaatgc 2580 gatatgactt ccttttgtaa tgctgctgat cccagtagac tatgactttt gataattagc 2640 agaatttaac tactgagtag ttgattattt tcacatttta attgctaatc actggctata 2700 taagtgtttt taagcaaagg tatttttgaa gtggtgtaga acccttccaa gctttcctgc 2760 tcagtgttct accagactta ccctggggcc tggcttaaaa gcaggattga agaaaaggga 2820 ctgggggaag gaaacttatt ggaaaacttg atgcgaatga gtttctgctt ggcacagtct 2880 ctgcctgctt gctctccttt gctgatggat tgcatttatc aaactattca tgctagcatt 2940 tttccaacga gggaacttat tccgcacggg cctactgtag gaccattgtc tcgtgtaatt 3000 aggaattttc catttgaagg attgctaaat tgtcacagta gtaggaagta tagggaaacc 3060 tctcagctgt ggcactgttg tagctttgga gtgcagagtg taactctggg acaatcagat 3120 ttcacatatt ctgtcatctt ggcataagcc attaaaagct tggagattac tgtatttggc 3180 attaaaaaaa aatgtcactt aggtcagcac tcccagacgt agcacagaaa aaccctttga 3240 cacaaaccat gtgttctgat ttttggttca gaaaatattg aaactgtgag ttgttttttt 3300 tttaacaact gggaaaaaac aaaaacaaaa aactatagtt agaaaaatgg aagttccata 3360 ggttctattt cttactctat gtatggcttt gttttcagtc tatttctagg agctttctct 3420 gaatcgctaa ttgtcctttc agttgaaatc taatttatac aatcattcta tacttaaagg 3480 ttaaatacat cttaattaat tttttcttaa agtcaatgta agtcactttg ttttgttttt 3540 ttttaatcta cgccatatgc ctcatgaaac cagctgttct agaatcagtc ctgagaatat 3600 ggcttaattc catggaaaca taactcctat cttgggacct gacataatat ctatctatcc 3660 tggggaactg gtaatatgag acttataggt tacagcagaa atgctacatg ttgacaaaag 3720 ccttaatcgt tccactggga gaactaattg ataattgtgt taagattgaa gattaaccct 3780 gtgttaatct cacttgagtc tatcctgaca gtagttcaga ttctggaaaa tgataaactg 3840 acctgctaga tgtagaattg tttcaaaatt agtgttgaaa taccttgttc acagatgaat 3900 atctgggcag gatctgaggg tgtttggaat gacacccccc aatccagttg catagatggg 3960 atgtctttgc aggtttgagg agatcatcga cctgcagagc cccctttgac ccagtacctc 4020 acgttttatt taaaatctaa atctggggcc aggcgtggtg gctcacgcct gtaatccaag 4080 cactttggga ggccgaagcg ggtggatcac ctgaggtcag gagtttgaga ccatcctggc 4140 caacatggtg aaaccccgtc tctactgaaa aaaatacaaa aattagctgg gcatggtggt 4200 agcacgcgcc tgtagtccca gctactcggg aggctgaggc aggataatcg cttgaacttg 4260 gcgggtagag gttgcagtga gccaagatgg tgccactaca ctgcagcctg ggtggctgag 4320 cgagactccg tctcaaaaaa aaaatctaaa tctgacattt gatgctattt ttattaatat 4380 tggaatgttc tgtcttgaac tttattcaat ataatcaaga ataaagatag agtaaacgtc 4440 actgatttgt actattaaga gagaaaaaat atgccacaca actaaacata ggtttaaatt 4500 atgaagaaat ttagaataga ggtttattag atttagggaa cactaagaac aaaaaaggaa 4560 ggagtgatac ctgcctgagt ggacagctgt aaatcagctg taattactgc agttgtacca 4620 atagttgtga gtggctccag tcactttagg agtccttgga agtacttggt acacatttgt 4680 tggctgtacc ttaaaggaag tggcaagtcc agtttgttct ctctaccaca ctagactgcc 4740 actgacaagt ttgggtctgt tggattcaaa attttgtaag ccattttcac aagtacaaag 4800 atacatttta accttgtctt ctccaaaatt actgagtagg aattttattt ttatcttttt 4860 gagacagggt atcactgtca cccagactgg agtgcagtgg tgggatcttg gcttactgtg 4920 acctctgcct cccgggttca aatggtcctc cctcctcagt ctcctgagta gctgggacga 4980 caggcacgtg ccaccatgcc cagctaattt gttctatttt ttctgtagag acggggtttt 5040 gccatgttgc ccaggctggt ctcagactcc tgggctcaag cgatcatttc gcctcagcct 5100 cccaaagtgc tgagattata ggtgtgagcc acagcatctg gcccagagtg aggagaatta 5160 atgagatttt ttgtgtgtgt tagataatat tgatttaagc ctttttttaa aaagtactct 5220 caaccaaata caaaattgaa aatgtgaggt ttaatagaaa tgtgttggct atttgcaatg 5280 gattttcttc ttgcccaagt gtttggagtt ctactttatg ctctgtattt aaaaattagt 5340 gacctcaaag cagagttgat gacacaggct ttggggccct catgttcttg tctttagaac 5400 atatcactac taagtatcag cttatcttca gaacattaca acattcaccg tgttcatatg 5460 ctttctgaga agtcaccact tgtaatttca gatcacatac acctgaaggc attttatagt 5520 tcctaaagtt aacatgttag atcttttttt tccaccccat gagggtctca ctctcaccca 5580 ggctggaatg cagtggtgtg attgtagcac actttggcca ccaactcctg ggctcaagtg 5640 atcctcctgc tttggcctcc tctgagaagc tgggattact ggtgcacacc accacacctg 5700 gctaattttt tatttttttt tatttttgga aatagggtat ggctatgttg ccttgggccc 5760 gtcatgaact cctagcctca ggtgaccctc ccacctcagg cctcccaaag ggttgggatt 5820 acaggagtga gctactgcac tgggccaaca tgttaatttt tttttttttt tttttgagat 5880 ggagtctccc aggcgggaat gcaatggtgc gatctcgact tcactgcaat cttcacctcc 5940 cgggttcgag cgattctccc acctcagcct cctgagtagc tgggattaca ggcacctgcc 6000 atcacgctcg gctaattttt gtattttgag cagagatgga gtttcaccat gttggccagg 6060 tgatctgcac tcccactccc cccacacttc ccaaagtgct gggattacag gcataagcca 6120 caagccacct cacccagcca acatgttaca tcttaattct tggattttct tcactgcagg 6180 gctttgggtg gagaaataaa actcttcaaa tgcatgatct tggagatccc tgtgaatcaa 6240 taattcttta gacaactgcg gctcaaaatc cctcctttcc cttttccgag ttattccatc 6300 catcttatta gaaaggaagt gaattaggtg taggtggtct gtaacacctg cacatctttt 6360 tatacgtgta gagggtatgc ctgggatata taggttgtct tcaagcagta gctgctacta 6420 cagctagaga gaggaggagt gccaggaaac tgatgacctg agaccaagag tcttgttgat 6480 gttctgactt agataaaggt tttgatcatt ttcatgaaat aatgcaggga agtcatttct 6540 gctgtttctt tactactcca ttcttggagg attagaacaa gtcacactgt aattgactaa 6600 aacgactttt tattttaaaa tattgatggt ggggttttgc tttttttttt tttttttttt 6660 ttgagacgtt gtcttgctct ttcacccagg gtagagtgca gtggcgaaat cttggctcac 6720 tgcaacctct gcctcccggg ttcaagcaat tctctgcctc agcctcctga gaagctggga 6780 ttacagcgcc tgccaccatg cctgtctagt ttttttgtat ttttagtaga gacaggggtt 6840 tcaccaagtt ggccaggctg gtcttgaact cctgacctcg tgatccaccc acctcggcct 6900 cccaaagtgc tgggattaca ggcgtgagcc accgtgccgg gccagtgttt ttaactgtcc 6960 acacttacta aattttccag tacttcttcc tatggttcat gatagtaaac acagaaacat 7020 ataaggaaca ttattagagt taccagatgt tagctgttgc atatgtgcac attcctagat 7080 tcaagggtgt ttttgcctta aatttaagtg ggtcattggt tgtcttggga agatcatgga 7140 aaattcggga ttttttagaa ttctgaacca aaatatgttt tgagtgtttc ttagtaaatg 7200 tgtgatcttc caccttccac attcagactg cggactacac ttcataaatg cctttttatt 7260 tccagttatg gattcaacta aatgactgcc ttgggagcac ataattactt tgctaccttt 7320 ttcccccttt gctgttgtgg ctcgagtttg gttctcacct gagaagatgc attgagcata 7380 tgttgttacc cagccctggc ttaatggtgt cctgtggggt aggggtggga ggacgagggg 7440 cacggggcca gagcatgtga atggatcatg gttggacagc tgtgacctgc cagcactgcg 7500 ggtaagcaaa actacaaacc gttctttcct ctgtgacatt gaataaacct taataaaatt 7560 cataattagc acatactaga aaaaa 7585 <210> 37 <211> 7585 <212> DNA <213> homo sapiens <400> 37 aaaaagtgct ttattttccc actccccgga cgcccagcag ggcagtttct tgaccttcgg 60 agcccctttc ccgaggatcc gctcgggagc ctcccctggc caggagcagg ggattagtct 120 gccccgcgac cggccccagc cacgacgcgg acatcgcccc ctctgtctgg gccgctgtca 180 ctcacgcgcc aaagggccac ggagaaagaa ggggcgggcc ggggcgggcc gggcgagcgg 240 aggcggggac ttgcgccgtc ctgaggctgc ctcctagggt ccggccggcg ctggagctgc 300 ggatttagat tgtcactgcc acctcggtcg gtgcttactt cgctgccagc tggtcgtcgc 360 catgaacccg gacctgcgca gggagcggga ttccgccagc ttcaacccgg agctgcttac 420 acacatcctg gacggcagcc ccgagaaaac ccggcgccgc cgagagatcg agaacatgat 480 cctgaacgac ccagacttcc agcatgagga cttgaacttc ctcactcgca gccagcgtta 540 tgaggtggct gtcaggaaaa gtgccatcat ggtgaagaag atgagggagt ttggcatcgc 600 tgaccctgat gaaattatgt ggtttaaaaa actacatttg gtcaattttg tggaacctgt 660 gggcctcaat tactccatgt ttattcctac cttgctgaat cagggcacca ctgctcagaa 720 agagaaatgg ctgctttcat ccaaaggact ccagataatt ggcacctacg cccagacgga 780 aatgggccac ggaactcacc ttcgaggctt ggaaaccaca gccacgtatg accctgaaac 840 ccaggagttc attctcaaca gtcctactgt gacctccatt aaatggtggc ctggtgggct 900 tggaaagact tcaaatcatg caatagttct tgcccagctc atcactaagg ggaaatgcta 960 tggattacat gcctttatcg tacctattcg tgaaatcggg acccataagc ctttgccagg 1020 aattaccgtt ggtgacatcg gccccaaatt tggttatgat gagatagaca atggctacct 1080 caaaatggac aaccatcgta ttcccagaga aaacatgctg atgaagtatg cccaggtgaa 1140 gcctgatggc acatacgtga aaccgctgag taacaagctg acttacggga ccatggtgtt 1200 tgtcaggtcc ttccttgtgg gagaagctgc tcgggctctg tctaaggcgt gcaccattgc 1260 catccgatac agcgctgtga ggcaccagtc tgaaatcaag ccaggtgaac cagaaccaca 1320 gattttggat tttcaaaccc agcagtataa actctttcca ctcctggcca ctgcctatgc 1380 cttccagttt gtgggcgcat acatgaagga gacctatcac cggattaacg aaggcattgg 1440 tcaaggggac ctgagtgaac tgcctgagct tcatgccctc accgctggac tgaaggcttt 1500 cacctcctgg actgcaaaca ctggcattga agcatgtcgg atggcttgtg gtgggcatgg 1560 ctattctcat tgcagtggtc ttccaaatat ttatgtcaat ttcaccccaa gctgtacctt 1620 tgagggagaa aacactgtca tgatgctcca gacggctagg ttcctgatga aaagttatga 1680 tcaggtgcac tcaggaaagt tggtgtgtgg catggtgtcc tatttgaacg acctgcccag 1740 tcagcgcatc cagccacagc aggtagcagt ctggccaacc atggtggata tcaacagccc 1800 cgaaagccta accgaagcat ataaactccg tgcagccaga ttagtagaaa ttgctgcaaa 1860 aaaccttcaa aaagaagtga ttcacagaaa aagcaaggag gtagcttgga acctaacttc 1920 tgttgacctt gttcgagcaa gtgaggcaca ttgccactat gtggtagtta agctcttttc 1980 agaaaaactc ctcaaaattc aagataaagc cattcaagct gtcttaagga gtttatgtct 2040 gctgtattct ctgtatggaa tcagtcagaa cgcgggggat ttccttcagg ggagcatcat 2100 gacagagcct cagattacac aagtaaacca gcgtgtaaag gagttactca ctctgattcg 2160 ctcagatgct gttgctttgg ttgatgcatt tgattttcag gatgtgacac ttggctctgt 2220 gcttggccgc tatgatggga atgtgtatga aaacttgttt gagtgggcta agaactcccc 2280 actgaacaaa gcagaggtcc acgaatctta caagcacctg aagtcactgc agtccaagct 2340 ctgaagtgtc acaaggacaa gtttaatctg cttcagaaag cgcctgtgtg caactcaaat 2400 tttgtggaat ctttttcgaa ttcaaatagc tatagagcaa atgataaatt gacccctttt 2460 tataaatgga gggaaaaaat gaacagattt cagagattaa atgaaaaaaa gcagatgttt 2520 taagtgcaat taacactgaa agagacctgt taaaccattc agaaaaagct taagaaatgc 2580 gatatgactt ccttttgtaa tgctgctgat cccagtagac tatgactttt gataattagc 2640 agaatttaac tactgagtag ttgattattt tcacatttta attgctaatc actggctata 2700 taagtgtttt taagcaaagg tatttttgaa gtggtgtaga acccttccaa gctttcctgc 2760 tcagtgttct accagactta ccctggggcc tggcttaaaa gcaggattga agaaaaggga 2820 ctgggggaag gaaacttatt ggaaaacttg atgcgaatga gtttctgctt ggcacagtct 2880 ctgcctgctt gctctccttt gctgatggat tgcatttatc aaactattca tgctagcatt 2940 tttccaacga gggaacttat tccgcacggg cctactgtag gaccattgtc tcgtgtaatt 3000 aggaattttc catttgaagg attgctaaat tgtcacagta gtaggaagta tagggaaacc 3060 tctcagctgt ggcactgttg tagctttgga gtgcagagtg taactctggg acaatcagat 3120 ttcacatatt ctgtcatctt ggcataagcc attaaaagct tggagattac tgtatttggc 3180 attaaaaaaa aatgtcactt aggtcagcac tcccagacgt agcacagaaa aaccctttga 3240 cacaaaccat gtgttctgat ttttggttca gaaaatattg aaactgtgag ttgttttttt 3300 tttaacaact gggaaaaaac aaaaacaaaa aactatagtt agaaaaatgg aagttccata 3360 ggttctattt cttactctat gtatggcttt gttttcagtc tatttctagg agctttctct 3420 gaatcgctaa ttgtcctttc agttgaaatc taatttatac aatcattcta tacttaaagg 3480 ttaaatacat cttaattaat tttttcttaa agtcaatgta agtcactttg ttttgttttt 3540 ttttaatcta cgccatatgc ctcatgaaac cagctgttct agaatcagtc ctgagaatat 3600 ggcttaattc catggaaaca taactcctat cttgggacct gacataatat ctatctatcc 3660 tggggaactg gtaatatgag acttataggt tacagcagaa atgctacatg ttgacaaaag 3720 ccttaatcgt tccactggga gaactaattg ataattgtgt taagattgaa gattaaccct 3780 gtgttaatct cacttgagtc tatcctgaca gtagttcaga ttctggaaaa tgataaactg 3840 acctgctaga tgtagaattg tttcaaaatt agtgttgaaa taccttgttc acagatgaat 3900 atctgggcag gatctgaggg tgtttggaat gacacccccc aatccagttg catagatggg 3960 atgtctttgc aggtttgagg agatcatcga cctgcagagc cccctttgac ccagtacctc 4020 acgttttatt taaaatctaa atctggggcc aggcgtggtg gctcacgcct gtaatccaag 4080 cactttggga ggccgaagcg ggtggatcac ctgaggtcag gagtttgaga ccatcctggc 4140 caacatggtg aaaccccgtc tctactgaaa aaaatacaaa aattagctgg gcatggtggt 4200 agcacgcgcc tgtagtccca gctactcggg aggctgaggc aggataatcg cttgaacttg 4260 gcgggtagag gttgcagtga gccaagatgg tgccactaca ctgcagcctg ggtggctgag 4320 cgagactccg tctcaaaaaa aaaatctaaa tctgacattt gatgctattt ttattaatat 4380 tggaatgttc tgtcttgaac tttattcaat ataatcaaga ataaagatag agtaaacgtc 4440 actgatttgt actattaaga gagaaaaaat atgccacaca actaaacata ggtttaaatt 4500 atgaagaaat ttagaataga ggtttattag atttagggaa cactaagaac aaaaaaggaa 4560 ggagtgatac ctgcctgagt ggacagctgt aaatcagctg taattactgc agttgtacca 4620 atagttgtga gtggctccag tcactttagg agtccttgga agtacttggt acacatttgt 4680 tggctgtacc ttaaaggaag tggcaagtcc agtttgttct ctctaccaca ctagactgcc 4740 actgacaagt ttgggtctgt tggattcaaa attttgtaag ccattttcac aagtacaaag 4800 atacatttta accttgtctt ctccaaaatt actgagtagg aattttattt ttatcttttt 4860 gagacagggt atcactgtca cccagactgg agtgcagtgg tgggatcttg gcttactgtg 4920 acctctgcct cccgggttca aatggtcctc cctcctcagt ctcctgagta gctgggacga 4980 caggcacgtg ccaccatgcc cagctaattt gttctatttt ttctgtagag acggggtttt 5040 gccatgttgc ccaggctggt ctcagactcc tgggctcaag cgatcatttc gcctcagcct 5100 cccaaagtgc tgagattata ggtgtgagcc acagcatctg gcccagagtg aggagaatta 5160 atgagatttt ttgtgtgtgt tagataatat tgatttaagc ctttttttaa aaagtactct 5220 caaccaaata caaaattgaa aatgtgaggt ttaatagaaa tgtgttggct atttgcaatg 5280 gattttcttc ttgcccaagt gtttggagtt ctactttatg ctctgtattt aaaaattagt 5340 gacctcaaag cagagttgat gacacaggct ttggggccct catgttcttg tctttagaac 5400 atatcactac taagtatcag cttatcttca gaacattaca acattcaccg tgttcatatg 5460 ctttctgaga agtcaccact tgtaatttca gatcacatac acctgaaggc attttatagt 5520 tcctaaagtt aacatgttag atcttttttt tccaccccat gagggtctca ctctcaccca 5580 ggctggaatg cagtggtgtg attgtagcac actttggcca ccaactcctg ggctcaagtg 5640 atcctcctgc tttggcctcc tctgagaagc tgggattact ggtgcacacc accacacctg 5700 gctaattttt tatttttttt tatttttgga aatagggtat ggctatgttg ccttgggccc 5760 gtcatgaact cctagcctca ggtgaccctc ccacctcagg cctcccaaag ggttgggatt 5820 acaggagtga gctactgcac tgggccaaca tgttaatttt tttttttttt tttttgagat 5880 ggagtctccc aggcgggaat gcaatggtgc gatctcgact tcactgcaat cttcacctcc 5940 cgggttcgag cgattctccc acctcagcct cctgagtagc tgggattaca ggcacctgcc 6000 atcacgctcg gctaattttt gtattttgag cagagatgga gtttcaccat gttggccagg 6060 tgatctgcac tcccactccc cccacacttc ccaaagtgct gggattacag gcataagcca 6120 caagccacct cacccagcca acatgttaca tcttaattct tggattttct tcactgcagg 6180 gctttgggtg gagaaataaa actcttcaaa tgcatgatct tggagatccc tgtgaatcaa 6240 taattcttta gacaactgcg gctcaaaatc cctcctttcc cttttccgag ttattccatc 6300 catcttatta gaaaggaagt gaattaggtg taggtggtct gtaacacctg cacatctttt 6360 tatacgtgta gagggtatgc ctgggatata taggttgtct tcaagcagta gctgctacta 6420 cagctagaga gaggaggagt gccaggaaac tgatgacctg agaccaagag tcttgttgat 6480 gttctgactt agataaaggt tttgatcatt ttcatgaaat aatgcaggga agtcatttct 6540 gctgtttctt tactactcca ttcttggagg attagaacaa gtcacactgt aattgactaa 6600 aacgactttt tattttaaaa tattgatggt ggggttttgc tttttttttt tttttttttt 6660 ttgagacgtt gtcttgctct ttcacccagg gtagagtgca gtggcgaaat cttggctcac 6720 tgcaacctct gcctcccggg ttcaagcaat tctctgcctc agcctcctga gaagctggga 6780 ttacagcgcc tgccaccatg cctgtctagt ttttttgtat ttttagtaga gacaggggtt 6840 tcaccaagtt ggccaggctg gtcttgaact cctgacctcg tgatccaccc acctcggcct 6900 cccaaagtgc tgggattaca ggcgtgagcc accgtgccgg gccagtgttt ttaactgtcc 6960 acacttacta aattttccag tacttcttcc tatggttcat gatagtaaac acagaaacat 7020 ataaggaaca ttattagagt taccagatgt tagctgttgc atatgtgcac attcctagat 7080 tcaagggtgt ttttgcctta aatttaagtg ggtcattggt tgtcttggga agatcatgga 7140 aaattcggga ttttttagaa ttctgaacca aaatatgttt tgagtgtttc ttagtaaatg 7200 tgtgatcttc caccttccac attcagactg cggactacac ttcataaatg cctttttatt 7260 tccagttatg gattcaacta aatgactgcc ttgggagcac ataattactt tgctaccttt 7320 ttcccccttt gctgttgtgg ctcgagtttg gttctcacct gagaagatgc attgagcata 7380 tgttgttacc cagccctggc ttaatggtgt cctgtggggt aggggtggga ggacgagggg 7440 cacggggcca gagcatgtga atggatcatg gttggacagc tgtgacctgc cagcactgcg 7500 ggtaagcaaa actacaaacc gttctttcct ctgtgacatt gaataaacct taataaaatt 7560 cataattagc acatactaga aaaaa 7585 <210> 38 <211> 4154 <212> DNA <213> homo sapiens <400> 38 acttggacgc gcttgcggag gattgcgttg acgagactct tatttattgt caccaacctg 60 tggtggaatt tgcagttgca cattggatct gattcgcccc gccccgaatg acgcctgccc 120 ggaggcagtg aaagtacagc cgcgccgccc caagtcagcc tggacacata aatcagcacg 180 cggccggaga accccgcaat ctctgcgccc acaaaataca ccgacgatgc ccgatctact 240 ttaagggctg aaacccacgg gcctgagaga ctataagagc gttccctacc gccatggaac 300 aacggggaca gaacgccccg gccgcttcgg gggcccggaa aaggcacggc ccaggaccca 360 gggaggcgcg gggagccagg cctgggcccc gggtccccaa gacccttgtg ctcgttgtcg 420 ccgcggtcct gctgttggtc tcagctgagt ctgctctgat cacccaacaa gacctagctc 480 cccagcagag agcggcccca caacaaaaga ggtccagccc ctcagaggga ttgtgtccac 540 ctggacacca tatctcagaa gacggtagag attgcatctc ctgcaaatat ggacaggact 600 atagcactca ctggaatgac ctccttttct gcttgcgctg caccaggtgt gattcaggtg 660 aagtggagct aagtccctgc accacgacca gaaacacagt gtgtcagtgc gaagaaggca 720 ccttccggga agaagattct cctgagatgt gccggaagtg ccgcacaggg tgtcccagag 780 ggatggtcaa ggtcggtgat tgtacaccct ggagtgacat cgaatgtgtc cacaaagaat 840 caggtacaaa gcacagtggg gaagtcccag ctgtggagga gacggtgacc tccagcccag 900 ggactcctgc ctctccctgt tctctctcag gcatcatcat aggagtcaca gttgcagccg 960 tagtcttgat tgtggctgtg tttgtttgca agtctttact gtggaagaaa gtccttcctt 1020 acctgaaagg catctgctca ggtggtggtg gggaccctga gcgtgtggac agaagctcac 1080 aacgacctgg ggctgaggac aatgtcctca atgagatcgt gagtatcttg cagcccaccc 1140 aggtccctga gcaggaaatg gaagtccagg agccagcaga gccaacaggt gtcaacatgt 1200 tgtcccccgg ggagtcagag catctgctgg aaccggcaga agctgaaagg tctcagagga 1260 ggaggctgct ggttccagca aatgaaggtg atcccactga gactctgaga cagtgcttcg 1320 atgactttgc agacttggtg ccctttgact cctgggagcc gctcatgagg aagttgggcc 1380 tcatggacaa tgagataaag gtggctaaag ctgaggcagc gggccacagg gacaccttgt 1440 acacgatgct gataaagtgg gtcaacaaaa ccgggcgaga tgcctctgtc cacaccctgc 1500 tggatgcctt ggagacgctg ggagagagac ttgccaagca gaagattgag gaccacttgt 1560 tgagctctgg aaagttcatg tatctagaag gtaatgcaga ctctgccatg tcctaagtgt 1620 gattctcttc aggaagtcag accttccctg gtttaccttt tttctggaaa aagcccaact 1680 ggactccagt cagtaggaaa gtgccacaat tgtcacatga ccggtactgg aagaaactct 1740 cccatccaac atcacccagt ggatggaaca tcctgtaact tttcactgca cttggcatta 1800 tttttataag ctgaatgtga taataaggac actatggaaa tgtctggatc attccgtttg 1860 tgcgtacttt gagatttggt ttgggatgtc attgttttca cagcactttt ttatcctaat 1920 gtaaatgctt tatttattta tttgggctac attgtaagat ccatctacac agtcgttgtc 1980 cgacttcact tgatactata tgatatgaac cttttttggg tggggggtgc ggggcagttc 2040 actctgtctc ccaggctgga gtgcaatggt gcaatcttgg ctcactatag ccttgacctc 2100 tcaggctcaa gcgattctcc cacctcagcc atccaaatag ctgggaccac aggtgtgcac 2160 caccacgccc ggctaatttt ttgtattttg tctagatata ggggctctct atgttgctca 2220 gggtggtctc gaattcctgg actcaagcag tctgcccacc tcagactccc aaagcggtgg 2280 aattagaggc gtgagccccc atgcttggcc ttacctttct acttttataa ttctgtatgt 2340 tattatttta tgaacatgaa gaaactttag taaatgtact tgtttacata gttatgtgaa 2400 tagattagat aaacataaaa ggaggagaca tacaatgggg gaagaagaag aagtcccctg 2460 taagatgtca ctgtctgggt tccagccctc cctcagatgt actttggctt caatgattgg 2520 caacttctac aggggccagt cttttgaact ggacaacctt acaagtatat gagtattatt 2580 tataggtagt tgtttacata tgagtcggga ccaaagagaa ctggatccac gtgaagtcct 2640 gtgtgtggct ggtccctacc tgggcagtct catttgcacc catagccccc atctatggac 2700 aggctgggac agaggcagat gggttagatc acacataaca atagggtcta tgtcatatcc 2760 caagtgaact tgagccctgt ttgggctcag gagatagaag acaaaatctg tctcccacgt 2820 ctgccatggc atcaaggggg aagagtagat ggtgcttgag aatggtgtga aatggttgcc 2880 atctcaggag tagatggccc ggctcacttc tggttatctg tcaccctgag cccatgagct 2940 gccttttagg gtacagattg cctacttgag gaccttggcc gctctgtaag catctgactc 3000 atctcagaaa tgtcaattct taaacactgt ggcaacagga cctagaatgg ctgacgcatt 3060 aaggttttct tcttgtgtcc tgttctatta ttgttttaag acctcagtaa ccatttcagc 3120 ctctttccag caaacccttc tccatagtat ttcagtcatg gaaggatcat ttatgcaggt 3180 agtcattcca ggagtttttg gtcttttctg tctcaaggca ttgtgtgttt tgttccggga 3240 ctggtttggg tgggacaaag ttagaattgc ctgaagatca cacattcaga ctgttgtgtc 3300 tgtggagttt taggagtggg gggtgacctt tctggtcttt gcacttccat cctctcccac 3360 ttccatctgg catcccacgc gttgtcccct gcacttctgg aaggcacagg gtgctgctgc 3420 ctcctggtct ttgcctttgc tgggccttct gtgcaggacg ctcagcctca gggctcagaa 3480 ggtgccagtc cggtcccagg tcccttgtcc cttccacaga ggccttccta gaagatgcat 3540 ctagagtgtc agccttatca gtgtttaaga tttttctttt atttttaatt tttttgagac 3600 agaatctcac tctctcgccc aggctggagt gcaacggtac gatcttggct cagtgcaacc 3660 tccgcctcct gggttcaagc gattctcgtg cctcagcctc cggagtagct gggattgcag 3720 gcacccgcca ccacgcctgg ctaatttttg tatttttagt agagacgggg tttcaccatg 3780 ttggtcaggc tggtctcgaa ctcctgacct caggtgatcc accttggcct ccgaaagtgc 3840 tgggattaca ggcgtgagcc accagccagg ccaagctatt cttttaaagt aagcttcctg 3900 acgacatgaa ataattgggg gttttgttgt ttagttacat taggctttgc tatatcccca 3960 ggccaaatag catgtgacac aggacagcca tagtatagtg tgtcactcgt ggttggtgtc 4020 ctttcatgct tctgccctgt caaaggtccc tatttgaaat gtgttataat acaaacaagg 4080 aagcacattg tgtacaaaat acttatgtat ttatgaatcc atgaccaaat taaatatgaa 4140 accttatata aaaa 4154 <210> 39 <211> 4067 <212> DNA <213> homo sapiens <400> 39 acttggacgc gcttgcggag gattgcgttg acgagactct tatttattgt caccaacctg 60 tggtggaatt tgcagttgca cattggatct gattcgcccc gccccgaatg acgcctgccc 120 ggaggcagtg aaagtacagc cgcgccgccc caagtcagcc tggacacata aatcagcacg 180 cggccggaga accccgcaat ctctgcgccc acaaaataca ccgacgatgc ccgatctact 240 ttaagggctg aaacccacgg gcctgagaga ctataagagc gttccctacc gccatggaac 300 aacggggaca gaacgccccg gccgcttcgg gggcccggaa aaggcacggc ccaggaccca 360 gggaggcgcg gggagccagg cctgggcccc gggtccccaa gacccttgtg ctcgttgtcg 420 ccgcggtcct gctgttggtc tcagctgagt ctgctctgat cacccaacaa gacctagctc 480 cccagcagag agcggcccca caacaaaaga ggtccagccc ctcagaggga ttgtgtccac 540 ctggacacca tatctcagaa gacggtagag attgcatctc ctgcaaatat ggacaggact 600 atagcactca ctggaatgac ctccttttct gcttgcgctg caccaggtgt gattcaggtg 660 aagtggagct aagtccctgc accacgacca gaaacacagt gtgtcagtgc gaagaaggca 720 ccttccggga agaagattct cctgagatgt gccggaagtg ccgcacaggg tgtcccagag 780 ggatggtcaa ggtcggtgat tgtacaccct ggagtgacat cgaatgtgtc cacaaagaat 840 caggcatcat cataggagtc acagttgcag ccgtagtctt gattgtggct gtgtttgttt 900 gcaagtcttt actgtggaag aaagtccttc cttacctgaa aggcatctgc tcaggtggtg 960 gtggggaccc tgagcgtgtg gacagaagct cacaacgacc tggggctgag gacaatgtcc 1020 tcaatgagat cgtgagtatc ttgcagccca cccaggtccc tgagcaggaa atggaagtcc 1080 aggagccagc agagccaaca ggtgtcaaca tgttgtcccc cggggagtca gagcatctgc 1140 tggaaccggc agaagctgaa aggtctcaga ggaggaggct gctggttcca gcaaatgaag 1200 gtgatcccac tgagactctg agacagtgct tcgatgactt tgcagacttg gtgccctttg 1260 actcctggga gccgctcatg aggaagttgg gcctcatgga caatgagata aaggtggcta 1320 aagctgaggc agcgggccac agggacacct tgtacacgat gctgataaag tgggtcaaca 1380 aaaccgggcg agatgcctct gtccacaccc tgctggatgc cttggagacg ctgggagaga 1440 gacttgccaa gcagaagatt gaggaccact tgttgagctc tggaaagttc atgtatctag 1500 aaggtaatgc agactctgcc atgtcctaag tgtgattctc ttcaggaagt cagaccttcc 1560 ctggtttacc ttttttctgg aaaaagccca actggactcc agtcagtagg aaagtgccac 1620 aattgtcaca tgaccggtac tggaagaaac tctcccatcc aacatcaccc agtggatgga 1680 acatcctgta acttttcact gcacttggca ttatttttat aagctgaatg tgataataag 1740 gacactatgg aaatgtctgg atcattccgt ttgtgcgtac tttgagattt ggtttgggat 1800 gtcattgttt tcacagcact tttttatcct aatgtaaatg ctttatttat ttatttgggc 1860 tacattgtaa gatccatcta cacagtcgtt gtccgacttc acttgatact atatgatatg 1920 aacctttttt gggtgggggg tgcggggcag ttcactctgt ctcccaggct ggagtgcaat 1980 ggtgcaatct tggctcacta tagccttgac ctctcaggct caagcgattc tcccacctca 2040 gccatccaaa tagctgggac cacaggtgtg caccaccacg cccggctaat tttttgtatt 2100 ttgtctagat ataggggctc tctatgttgc tcagggtggt ctcgaattcc tggactcaag 2160 cagtctgccc acctcagact cccaaagcgg tggaattaga ggcgtgagcc cccatgcttg 2220 gccttacctt tctactttta taattctgta tgttattatt ttatgaacat gaagaaactt 2280 tagtaaatgt acttgtttac atagttatgt gaatagatta gataaacata aaaggaggag 2340 acatacaatg ggggaagaag aagaagtccc ctgtaagatg tcactgtctg ggttccagcc 2400 ctccctcaga tgtactttgg cttcaatgat tggcaacttc tacaggggcc agtcttttga 2460 actggacaac cttacaagta tatgagtatt atttataggt agttgtttac atatgagtcg 2520 ggaccaaaga gaactggatc cacgtgaagt cctgtgtgtg gctggtccct acctgggcag 2580 tctcatttgc acccatagcc cccatctatg gacaggctgg gacagaggca gatgggttag 2640 atcacacata acaatagggt ctatgtcata tcccaagtga acttgagccc tgtttgggct 2700 caggagatag aagacaaaat ctgtctccca cgtctgccat ggcatcaagg gggaagagta 2760 gatggtgctt gagaatggtg tgaaatggtt gccatctcag gagtagatgg cccggctcac 2820 ttctggttat ctgtcaccct gagcccatga gctgcctttt agggtacaga ttgcctactt 2880 gaggaccttg gccgctctgt aagcatctga ctcatctcag aaatgtcaat tcttaaacac 2940 tgtggcaaca ggacctagaa tggctgacgc attaaggttt tcttcttgtg tcctgttcta 3000 ttattgtttt aagacctcag taaccatttc agcctctttc cagcaaaccc ttctccatag 3060 tatttcagtc atggaaggat catttatgca ggtagtcatt ccaggagttt ttggtctttt 3120 ctgtctcaag gcattgtgtg ttttgttccg ggactggttt gggtgggaca aagttagaat 3180 tgcctgaaga tcacacattc agactgttgt gtctgtggag ttttaggagt ggggggtgac 3240 ctttctggtc tttgcacttc catcctctcc cacttccatc tggcatccca cgcgttgtcc 3300 cctgcacttc tggaaggcac agggtgctgc tgcctcctgg tctttgcctt tgctgggcct 3360 tctgtgcagg acgctcagcc tcagggctca gaaggtgcca gtccggtccc aggtcccttg 3420 tcccttccac agaggccttc ctagaagatg catctagagt gtcagcctta tcagtgttta 3480 agatttttct tttattttta atttttttga gacagaatct cactctctcg cccaggctgg 3540 agtgcaacgg tacgatcttg gctcagtgca acctccgcct cctgggttca agcgattctc 3600 gtgcctcagc ctccggagta gctgggattg caggcacccg ccaccacgcc tggctaattt 3660 ttgtattttt agtagagacg gggtttcacc atgttggtca ggctggtctc gaactcctga 3720 cctcaggtga tccaccttgg cctccgaaag tgctgggatt acaggcgtga gccaccagcc 3780 aggccaagct attcttttaa agtaagcttc ctgacgacat gaaataattg ggggttttgt 3840 tgtttagtta cattaggctt tgctatatcc ccaggccaaa tagcatgtga cacaggacag 3900 ccatagtata gtgtgtcact cgtggttggt gtcctttcat gcttctgccc tgtcaaaggt 3960 ccctatttga aatgtgttat aatacaaaca aggaagcaca ttgtgtacaa aatacttatg 4020 tatttatgaa tccatgacca aattaaatat gaaaccttat ataaaaa 4067 <210> 40 <211> 6564 <212> DNA <213> homo sapiens <400> 40 ccaggcggcg ttgcggcccc ggccccggct ccctgcgccg ccgccgccgc cgccgccagc 60 gctagcgcca gcagccgggc ccgatcaccc gccgcccggt gcccgccgcc gcccgcgcca 120 gcaaccgggc ccgatcaccc gccgcccggt gcccgccgcc gcccgcgcca ccggcatggc 180 gctccggggc ttctgcagcg ccgatggctc cgacccgctc tgggactgga atgtcacgtg 240 gaataccagc aaccccgact tcaccaagtg ctttcagaac acggtcctcg tgtgggtgcc 300 ttgtttttac ctctgggcct gtttcccctt ctacttcctc tatctctccc gacatgaccg 360 aggctacatt cagatgacac ctctcaacaa aaccaaaact gccttgggat ttttgctgtg 420 gatcgtctgc tgggcagacc tcttctactc tttctgggaa agaagtcggg gcatattcct 480 ggccccagtg tttctggtca gcccaactct cttgggcatc accatgctgc ttgctacctt 540 tttaattcag ctggagagga ggaagggagt tcagtcttca gggatcatgc tcactttctg 600 gctggtagcc ctagtgtgtg ccctagccat cctgagatcc aaaattatga cagccttaaa 660 agaggatgcc caggtggacc tgtttcgtga catcactttc tacgtctact tttccctctt 720 actcattcag ctcgtcttgt cctgtttctc agatcgctca cccctgttct cggaaaccat 780 ccacgaccct aatccctgcc cagagtccag cgcttccttc ctgtcgagga tcaccttctg 840 gtggatcaca gggttgattg tccggggcta ccgccagccc ctggagggca gtgacctctg 900 gtccttaaac aaggaggaca cgtcggaaca agtcgtgcct gttttggtaa agaactggaa 960 gaaggaatgc gccaagacta ggaagcagcc ggtgaaggtt gtgtactcct ccaaggatcc 1020 tgcccagccg aaagagagtt ccaaggtgga tgcgaatgag gaggtggagg ctttgatcgt 1080 caagtcccca cagaaggagt ggaacccctc tctgtttaag gtgttataca agacctttgg 1140 gccctacttc ctcatgagct tcttcttcaa ggccatccac gacctgatga tgttttccgg 1200 gccgcagatc ttaaagttgc tcatcaagtt cgtgaatgac acgaaggccc cagactggca 1260 gggctacttc tacaccgtgc tgctgtttgt cactgcctgc ctgcagaccc tcgtgctgca 1320 ccagtacttc cacatctgct tcgtcagtgg catgaggatc aagaccgctg tcattggggc 1380 tgtctatcgg aaggccctgg tgatcaccaa ttcagccaga aaatcctcca cggtcgggga 1440 gattgtcaac ctcatgtctg tggacgctca gaggttcatg gacttggcca cgtacattaa 1500 catgatctgg tcagcccccc tgcaagtcat ccttgctctc tacctcctgt ggctgaatct 1560 gggcccttcc gtcctggctg gagtggcggt gatggtcctc atggtgcccg tcaatgctgt 1620 gatggcgatg aagaccaaga cgtatcaggt ggcccacatg aagagcaaag acaatcggat 1680 caagctgatg aacgaaattc tcaatgggat caaagtgcta aagctttatg cctgggagct 1740 ggcattcaag gacaaggtgc tggccatcag gcaggaggag ctgaaggtgc tgaagaagtc 1800 tgcctacctg tcagccgtgg gcaccttcac ctgggtctgc acgccctttc tggtggcctt 1860 gtgcacattt gccgtctacg tgaccattga cgagaacaac atcctggatg cccagacagc 1920 cttcgtgtct ttggccttgt tcaacatcct ccggtttccc ctgaacattc tccccatggt 1980 catcagcagc atcgtgcagg cgagtgtctc cctcaaacgc ctgaggatct ttctctccca 2040 tgaggagctg gaacctgaca gcatcgagcg acggcctgtc aaagacggcg ggggcacgaa 2100 cagcatcacc gtgaggaatg ccacattcac ctgggccagg agcgaccctc ccacactgaa 2160 tggcatcacc ttctccatcc ccgaaggtgc tttggtggcc gtggtgggcc aggtgggctg 2220 cggaaagtcg tccctgctct cagccctctt ggctgagatg gacaaagtgg aggggcacgt 2280 ggctatcaag ggctccgtgg cctatgtgcc acagcaggcc tggattcaga atgattctct 2340 ccgagaaaac atcctttttg gatgtcagct ggaggaacca tattacaggt ccgtgataca 2400 ggcctgtgcc ctcctcccag acctggaaat cctgcccagt ggggatcgga cagagattgg 2460 cgagaagggc gtgaacctgt ctgggggcca gaagcagcgc gtgagcctgg cccgggccgt 2520 gtactccaac gctgacattt acctcttcga tgatcccctc tcagcagtgg atgcccatgt 2580 gggaaaacac atctttgaaa atgtgattgg ccccaagggg atgctgaaga acaagacgcg 2640 gatcttggtc acgcacagca tgagctactt gccgcaggtg gacgtcatca tcgtcatgag 2700 tggcggcaag atctctgaga tgggctccta ccaggagctg ctggctcgag acggcgcctt 2760 cgctgagttc ctgcgtacct atgccagcac agagcaggag caggatgcag aggagaacgg 2820 ggtcacgggc gtcagcggtc cagggaagga agcaaagcaa atggagaatg gcatgctggt 2880 gacggacagt gcagggaagc aactgcagag acagctcagc agctcctcct cctatagtgg 2940 ggacatcagc aggcaccaca acagcaccgc agaactgcag aaagctgagg ccaagaagga 3000 ggagacctgg aagctgatgg aggctgacaa ggcgcagaca gggcaggtca agctttccgt 3060 gtactgggac tacatgaagg ccatcggact cttcatctcc ttcctcagca tcttcctttt 3120 catgtgtaac catgtgtccg cgctggcttc caactattgg ctcagcctct ggactgatga 3180 ccccatcgtc aacgggactc aggagcacac gaaagtccgg ctgagcgtct atggagccct 3240 gggcatttca caagggatcg ccgtgtttgg ctactccatg gccgtgtcca tcggggggat 3300 cttggcttcc cgctgtctgc acgtggacct gctgcacagc atcctgcggt cacccatgag 3360 cttctttgag cggaccccca gtgggaacct ggtgaaccgc ttctccaagg agctggacac 3420 agtggactcc atgatcccgg aggtcatcaa gatgttcatg ggctccctgt tcaacgtcat 3480 tggtgcctgc atcgttatcc tgctggccac gcccatcgcc gccatcatca tcccgcccct 3540 tggcctcatc tacttcttcg tccagaggtt ctacgtggct tcctcccggc agctgaagcg 3600 cctcgagtcg gtcagccgct ccccggtcta ttcccatttc aacgagacct tgctgggggt 3660 cagcgtcatt cgagccttcg aggagcagga gcgcttcatc caccagagtg acctgaaggt 3720 ggacgagaac cagaaggcct attaccccag catcgtggcc aacaggtggc tggccgtgcg 3780 gctggagtgt gtgggcaact gcatcgttct gtttgctgcc ctgtttgcgg tgatctccag 3840 gcacagcctc agtgctggct tggtgggcct ctcagtgtct tactcattgc aggtcaccac 3900 gtacttgaac tggctggttc ggatgtcatc tgaaatggaa accaacatcg tggccgtgga 3960 gaggctcaag gagtattcag agactgagaa ggaggcgccc tggcaaatcc aggagacagc 4020 tccgcccagc agctggcccc aggtgggccg agtggaattc cggaactact gcctgcgcta 4080 ccgagaggac ctggacttcg ttctcaggca catcaatgtc acgatcaatg ggggagaaaa 4140 ggtcggcatc gtggggcgga cgggagctgg gaagtcgtcc ctgaccctgg gcttatttcg 4200 gatcaacgag tctgccgaag gagagatcat catcgatggc atcaacatcg ccaagatcgg 4260 cctgcacgac ctccgcttca agatcaccat catcccccag gaccctgttt tgttttcggg 4320 ttccctccga atgaacctgg acccattcag ccagtactcg gatgaagaag tctggacgtc 4380 cctggagctg gcccacctga aggacttcgt gtcagccctt cctgacaagc tagaccatga 4440 atgtgcagaa ggcggggaga acctcagtgt cgggcagcgc cagcttgtgt gcctagcccg 4500 ggccctgctg aggaagacga agatccttgt gttggatgag gccacggcag ccgtggacct 4560 ggaaacggac gacctcatcc agtccaccat ccggacacag ttcgaggact gcaccgtcct 4620 caccatcgcc caccggctca acaccatcat ggactacaca agggtgatcg tcttggacaa 4680 aggagaaatc caggagtacg gcgccccatc ggacctcctg cagcagagag gtcttttcta 4740 cagcatggcc aaagacgccg gcttggtgtg agccccagag ctggcatatc tggtcagaac 4800 tgcagggcct atatgccagc gcccagggag gagtcagtac ccctggtaaa ccaagcctcc 4860 cacactgaaa ccaaaacata aaaaccaaac ccagacaacc aaaacatatt caaagcagca 4920 gccaccgcca tccggtcccc tgcctggaac tggctgtgaa gacccaggag agacagagat 4980 gcgaaccacc caaaacacgc acaccctgcc cctggtgccc tgagacagac acacagcctc 5040 acgcccccag gaatgcaagt ggtttcctgg tgcttcccac ggaggagttt tggcagccag 5100 acttctggag gaattggttg tatagaagat cctagtgacc aaattcagcc tactgcctcg 5160 gatctctcca gccgaagtct gtggactgca agtctttgag atgcttctgg ctcccatcac 5220 ctctaacatc cttgtctggg tctaccagga acgcttcatt tccttggggc tgcagttttg 5280 tggttgaggg gcctggagaa aatcattttc tccccttggc agtgtcccag ggccctggat 5340 ggtcctctta ccaacatctg gtcttccagg cactcaaaag ctgggaacca gcatctcagc 5400 gccagctcta ccagttctcg ttttgggcca gaggcagcct ctgcactccc acgcctgtcc 5460 tcctggaagg gacctggttg gactaacggc taacctggac ctggaactgt agggccaggg 5520 gattgtctca gggccgacgt tccacctggg gcttccctcc ccacccaccc cgactccagg 5580 ctttcccttt tttcttttgt tcaacattgt aagaacaatc aatgctgtta ttactgttcc 5640 caccatgatt gatgtggggt aaatattaag gagatggcct catgggaatt tgaccttgac 5700 tagaaataga gactgagagt gagcaaccag ctggaaggta ctatgccagt cctagcagaa 5760 aaatgtgtta ggggcctggc ccaaagcagt gttggttgct tacagtgttg attgattttg 5820 ttcttttttc ttaccacctc ttttctttcc ctctcatggt acctgctcat ggttatgaag 5880 ctttcaaagt aaagaacacg aaatacctcc caagtattac cagtgggtac caaaaaaatg 5940 tccccttgag tcttttcctt gtttttagat gttaattctc tcccttggca tccggttagc 6000 cccccagggg gggcagcatt gtggagaact tgatatttag ttactgatgc tcttccagga 6060 cacgaaaaga acccatcttt gaatatcaat gatttttttt ttttaagtac tgttccgggg 6120 agaaaaacag tctcaaaact tgaacttctt gggaatagaa gtgttgggct gagaagtaac 6180 attcccagga aatagtgaga agctcgccct gtgtttgaaa ccgtgttggt ctctgtgttc 6240 ctggaagaaa acagggaagc agcatctttt aaagcctgtt ctttaaggtg tctcgttaga 6300 gcccaaagtg gaatccggaa ggcagccaga gctgaggctg ccccaagact cagacttgct 6360 aagaattacg ccgccgactt caaacccaga gagcatcttt cttttaggcg aaaacgcata 6420 tatttatttt ttgtaagtta taccattctt tcacattaga taaactaagt tttgggggat 6480 ccttttgtaa tgacttacac tggaaatgcg aacatttgca gtaaaaaaat atatatatat 6540 ctatatattt tatttctttc taaa 6564 <210> 41 <211> 1958 <212> DNA <213> homo sapiens <400> 41 gcggaggcgg ctccggcgcc cgctctgccc gccgctgggt ccgaccgcgc tcgccttcct 60 tgcagccgcg cctcggcccc atggacgccc tgtgcggttc cggggagctc ggctccaagt 120 tctgggactc caacctgtct gtgcacacag aaaacccgga cctcactccc tgcttccaga 180 actccctgct ggcctgggtg ccctgcatct acctgtgggt cgccctgccc tgctacttgc 240 tctacctgcg gcaccattgt cgtggctaca tcatcctctc ccacctgtcc aagctcaaga 300 tggtcctggg tgtcctgctg tggtgcgtct cctgggcgga ccttttttac tccttccatg 360 gcctggtcca tggccgggcc cctgcccctg ttttctttgt cacccccttg gtggtggggg 420 tcaccatgct gctggccacc ctgctgatac agtatgagcg gctgcagggc gtacagtctt 480 cgggggtcct cattatcttc tggttcctgt gtgtggtctg cgccatcgtc ccattccgct 540 ccaagatcct tttagccaag gcagagggtg agatctcaga ccccttccgc ttcaccacct 600 tctacatcca ctttgccctg gtactctctg ccctcatctt ggcctgcttc agggagaaac 660 ctccattttt ctccgcaaag aatgtcgacc ctaaccccta ccctgagacc agcgctggct 720 ttctctcccg cctgtttttc tggtggttca caaagatggc catctatggc taccggcatc 780 ccctggagga gaaggacctc tggtccctaa aggaagagga cagatcccag atggtggtgc 840 agcagctgct ggaggcatgg aggaagcagg aaaagcagac ggcacgacac aaggcttcag 900 cagcacctgg gaaaaatgcc tccggcgagg acgaggtgct gctgggtgcc cggcccaggc 960 cccggaagcc ctccttcctg aaggccctgc tggccacctt cggctccagc ttcctcatca 1020 gtgcctgctt caagcttatc caggacctgc tctccttcat caatccacag ctgctcagca 1080 tcctgatcag gtttatctcc aaccccatgg ccccctcctg gtggggcttc ctggtggctg 1140 ggctgatgtt cctgtgctcc atgatgcagt cgctgatctt acaacactat taccactaca 1200 tctttgtgac tggggtgaag tttcgtactg ggatcatggg tgtcatctac aggaaggctc 1260 tggttatcac caactcagtc aaacgtgcgt ccactgtggg ggaaattgtc aacctcatgt 1320 cagtggatgc ccagcgcttc atggaccttg cccccttcct caatctgctg tggtcagcac 1380 ccctgcagat catcctggcg atctacttcc tctggcagaa cctaggtccc tctgtcctgg 1440 ctggagtcgc tttcatggtc ttgctgattc cactcaacgg agctgtggcc gtgaagatgc 1500 gcgccttcca ggtaaagcaa atgaaattga aggactcgcg catcaagctg atgagtgaga 1560 tcctgaacgg catcaaggtg ctgaagctgt acgcctggga gcccagcttc ctgaagcagg 1620 tggagggcat caggcagggt gagctccagc tgctgcgcac ggcggcctac ctccacacca 1680 caaccacctt cacctggatg tgcagcccct tcctggtgag gcttggcaca gggctgggtc 1740 cctgcctcca gggctctggg tgcccaggca tggccagggc tcattggact ctaccctgac 1800 accacctcca cgctgctcag gtgaccctga tcaccctctg ggtgtacgtg tacgtggacc 1860 caaacaatgt gctggacgcc gagaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa 1920 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaa 1958 <210> 42 <211> 5183 <212> DNA <213> homo sapiens <400> 42 gcggaggcgg ctccggcgcc cgctctgccc gccgctgggt ccgaccgcgc tcgccttcct 60 tgcagccgcg cctcggcccc atggacgccc tgtgcggttc cggggagctc ggctccaagt 120 tctgggactc caacctgtct gtgcacacag aaaacccgga cctcactccc tgcttccaga 180 actccctgct ggcctgggtg ccctgcatct acctgtgggt cgccctgccc tgctacttgc 240 tctacctgcg gcaccattgt cgtggctaca tcatcctctc ccacctgtcc aagctcaaga 300 tggtcctggg tgtcctgctg tggtgcgtct cctgggcgga ccttttttac tccttccatg 360 gcctggtcca tggccgggcc cctgcccctg ttttctttgt cacccccttg gtggtggggg 420 tcaccatgct gctggccacc ctgctgatac agtatgagcg gctgcagggc gtacagtctt 480 cgggggtcct cattatcttc tggttcctgt gtgtggtctg cgccatcgtc ccattccgct 540 ccaagatcct tttagccaag gcagagggtg agatctcaga ccccttccgc ttcaccacct 600 tctacatcca ctttgccctg gtactctctg ccctcatctt ggcctgcttc agggagaaac 660 ctccattttt ctccgcaaag aatgtcgacc ctaaccccta ccctgagacc agcgctggct 720 ttctctcccg cctgtttttc tggtggttca caaagatggc catctatggc taccggcatc 780 ccctggagga gaaggacctc tggtccctaa aggaagagga cagatcccag atggtggtgc 840 agcagctgct ggaggcatgg aggaagcagg aaaagcagac ggcacgacac aaggcttcag 900 cagcacctgg gaaaaatgcc tccggcgagg acgaggtgct gctgggtgcc cggcccaggc 960 cccggaagcc ctccttcctg aaggccctgc tggccacctt cggctccagc ttcctcatca 1020 gtgcctgctt caagcttatc caggacctgc tctccttcat caatccacag ctgctcagca 1080 tcctgatcag gtttatctcc aaccccatgg ccccctcctg gtggggcttc ctggtggctg 1140 ggctgatgtt cctgtgctcc atgatgcagt cgctgatctt acaacactat taccactaca 1200 tctttgtgac tggggtgaag tttcgtactg ggatcatggg tgtcatctac aggaaggctc 1260 tggttatcac caactcagtc aaacgtgcgt ccactgtggg ggaaattgtc aacctcatgt 1320 cagtggatgc ccagcgcttc atggaccttg cccccttcct caatctgctg tggtcagcac 1380 ccctgcagat catcctggcg atctacttcc tctggcagaa cctaggtccc tctgtcctgg 1440 ctggagtcgc tttcatggtc ttgctgattc cactcaacgg agctgtggcc gtgaagatgc 1500 gcgccttcca ggtaaagcaa atgaaattga aggactcgcg catcaagctg atgagtgaga 1560 tcctgaacgg catcaaggtg ctgaagctgt acgcctggga gcccagcttc ctgaagcagg 1620 tggagggcat caggcagggt gagctccagc tgctgcgcac ggcggcctac ctccacacca 1680 caaccacctt cacctggatg tgcagcccct tcctggtgac cctgatcacc ctctgggtgt 1740 acgtgtacgt ggacccaaac aatgtgctgg acgccgagaa ggcctttgtg tctgtgtcct 1800 tgtttaatat cttaagactt cccctcaaca tgctgcccca gttaatcagc aacctgactc 1860 aggccagtgt gtctctgaaa cggatccagc aattcctgag ccaagaggaa cttgaccccc 1920 agagtgtgga aagaaagacc atctccccag gctatgccat caccatacac agtggcacct 1980 tcacctgggc ccaggacctg ccccccactc tgcacagcct agacatccag gtcccgaaag 2040 gggcactggt ggccgtggtg gggcctgtgg gctgtgggaa gtcctccctg gtgtctgccc 2100 tgctgggaga gatggagaag ctagaaggca aagtgcacat gaagggctcc gtggcctatg 2160 tgccccagca ggcatggatc cagaactgca ctcttcagga aaacgtgctt ttcggcaaag 2220 ccctgaaccc caagcgctac cagcagactc tggaggcctg tgccttgcta gctgacctgg 2280 agatgctgcc tggtggggat cagacagaga ttggagagaa gggcattaac ctgtctgggg 2340 gccagcggca gcgggtcagt ctggctcgag ctgtttacag tgatgccgat attttcttgc 2400 tggatgaccc actgtccgcg gtggactctc atgtggccaa gcacatcttt gaccacgtca 2460 tcgggccaga aggcgtgctg gcaggcaaga cgcgagtgct ggtgacgcac ggcattagct 2520 tcctgcccca gacagacttc atcattgtgc tagctgatgg acaggtgtct gagatgggcc 2580 cgtacccagc cctgctgcag cgcaacggct cctttgccaa ctttctctgc aactatgccc 2640 ccgatgagga ccaagggcac ctggaggaca gctggaccgc gttggaaggt gcagaggata 2700 aggaggcact gctgattgaa gacacactca gcaaccacac ggatctgaca gacaatgatc 2760 cagtcaccta tgtggtccag aagcagttta tgagacagct gagtgccctg tcctcagatg 2820 gggagggaca gggtcggcct gtaccccgga ggcacctggg tccatcagag aaggtgcagg 2880 tgacagaggc gaaggcagat ggggcactga cccaggagga gaaagcagcc attggcactg 2940 tggagctcag tgtgttctgg gattatgcca aggccgtggg gctctgtacc acgctggcca 3000 tctgtctcct gtatgtgggt caaagtgcgg ctgccattgg agccaatgtg tggctcagtg 3060 cctggacaaa tgatgccatg gcagacagta gacagaacaa cacttccctg aggctgggcg 3120 tctatgctgc tttaggaatt ctgcaagggt tcttggtgat gctggcagcc atggccatgg 3180 cagcgggtgg catccaggct gcccgtgtgt tgcaccaggc actgctgcac aacaagatac 3240 gctcgccaca gtccttcttt gacaccacac catcaggccg catcctgaac tgcttctcca 3300 aggacatcta tgtcgttgat gaggttctgg cccctgtcat cctcatgctg ctcaattcct 3360 tcttcaacgc catctccact cttgtggtca tcatggccag cacgccgctc ttcactgtgg 3420 tcatcctgcc cctggctgtg ctctacacct tagtgcagcg cttctatgca gccacatcac 3480 ggcaactgaa gcggctggaa tcagtcagcc gctcacctat ctactcccac ttttcggaga 3540 cagtgactgg tgccagtgtc atccgggcct acaaccgcag ccgggatttt gagatcatca 3600 gtgatactaa ggtggatgcc aaccagagaa gctgctaccc ctacatcatc tccaaccggt 3660 ggctgagcat cggagtggag ttcgtgggga actgcgtggt gctctttgct gcactatttg 3720 ccgtcatcgg gaggagcagc ctgaacccgg ggctggtggg cctttctgtg tcctactcct 3780 tgcaggtgac atttgctctg aactggatga tacgaatgat gtcagatttg gaatctaaca 3840 tcgtggctgt ggagagggtc aaggagtact ccaagacaga gacagaggcg ccctgggtgg 3900 tggaaggcag ccgccctccc gaaggttggc ccccacgtgg ggaggtggag ttccggaatt 3960 attctgtgcg ctaccggccg ggcctagacc tggtgctgag agacctgagt ctgcatgtgc 4020 acggtggcga gaaggtgggg atcgtgggcc gcactggggc tggcaagtct tccatgaccc 4080 tttgcctgtt ccgcatcctg gaggcggcaa agggtgaaat ccgcattgat ggcctcaatg 4140 tggcagacat cggcctccat gacctgcgct ctcagctgac catcatcccg caggacccca 4200 tcctgttctc ggggaccctg cgcatgaacc tggacccctt cggcagctac tcagaggagg 4260 acatttggtg ggctttggag ctgtcccacc tgcacacgtt tgtgagctcc cagccggcag 4320 gcctggactt ccagtgctca gagggcgggg agaatctcag cgtgggccag aggcagctcg 4380 tgtgcctggc ccgagccctg ctccgcaaga gccgcatcct ggttttagac gaggccacag 4440 ctgccatcga cctggagact gacaacctca tccaggctac catccgcacc cagtttgata 4500 cctgcactgt cctgaccatc gcacaccggc ttaacactat catggactac accagggtcc 4560 tggtcctgga caaaggagta gtagctgaat ttgattctcc agccaacctc attgcagcta 4620 gaggcatctt ctacgggatg gccagagatg ctggacttgc ctaaaatata ttcctgagat 4680 ttcctcctgg cctttcctgg ttttcatcag gaaggaaatg acaccaaata tgtccgcaga 4740 atggacttga tagcaaacac tgggggcacc ttaagatttt gcacctgtaa agtgccttac 4800 agggtaactg tgctgaatgc tttagatgag gaaatgatcc ccaagtggtg aatgacacgc 4860 ctaaggtcac agctagtttg agccagttag actagtcccc ggtctcccga ttcccaactg 4920 agtgttattt gcacactgca ctgttttcaa ataacgattt tatgaaatga cctctgtcct 4980 ccctctgatt tttcatattt tctaaagttt cgtttctgtt ttttaataaa aagctttttc 5040 ctcctggaac agaagacagc tgctgggtca ggccacccct aggaactcag tcctgtactc 5100 tggggtgctg cctgaatcca ttaaaaatgg gagtactgat gaaataaaac tacatggtca 5160 acagtaaaaa aaaaaaaaaa aaa 5183 <210> 43 <211> 3979 <212> DNA <213> homo sapiens <400> 43 atttgaaaac ttggcaacct tggattggat ggattcatat ttcttagtat agaagttctt 60 gatataactg aaaaattaag ttaaacactt aataagtggt ggttactcag cacttttaga 120 tgctgtttat aatagatgac cttttctaac taatttacag ttttttgaaa gataactgag 180 aggttgaggg acggagattt tcttcaagca attttttttt tcattttaaa tgagctccca 240 atgtcggagt ttggaaaaca aatttgtctt tttaaaagaa ggtctaggaa actcaaaacc 300 tgaagaattg gaagaaatca gaatagaaaa tggtaggata agttctgaac gtcgaaaaga 360 aaagtctcga gatgcagcca gatctcggcg aagtaaagaa tctgaagttt tttatgagct 420 tgctcatcag ttgccacttc cacataatgt gagttcgcat cttgataagg cctctgtgat 480 gaggcttacc atcagctatt tgcgtgtgag gaaacttctg gatgctggtg atttggatat 540 tgaagatgac atgaaagcac agatgaattg cttttatttg aaagccttgg atggttttgt 600 tatggttctc acagatgatg gtgacatgat ttacatttct gataatgtga acaaatacat 660 gggattaact cagtttgaac taactggaca cagtgtgttt gattttactc atccatgtga 720 ccatgaggaa atgagagaaa tgcttacaca cagaaatggc cttgtgaaaa agggtaaaga 780 acaaaacaca cagcgaagct tttttctcag aatgaagtgt accctaacta gccgaggaag 840 aactatgaac ataaagtctg caacatggaa ggtattgcac tgcacaggcc acattcacgt 900 atatgatacc aacagtaacc aacctcagtg tgggtataag aaaccaccta tgacctgctt 960 ggtgctgatt tgtgaaccca ttcctcaccc atcaaatatt gaaattcctt tagatagcaa 1020 gactttcctc agtcgacaca gcctggatat gaaattttct tattgtgatg aaagaattac 1080 cgaattgatg ggatatgagc cagaagaact tttaggccgc tcaatttatg aatattatca 1140 tgctttggac tctgatcatc tgaccaaaac tcatcatgat atgtttacta aaggacaagt 1200 caccacagga cagtacagga tgcttgccaa aagaggtgga tatgtctggg ttgaaactca 1260 agcaactgtc atatataaca ccaagaattc tcaaccacag tgcattgtat gtgtgaatta 1320 cgttgtgagt ggtattattc agcacgactt gattttctcc cttcaacaaa cagaatgtgt 1380 ccttaaaccg gttgaatctt cagatatgaa aatgactcag ctattcacca aagttgaatc 1440 agaagataca agtagcctct ttgacaaact taagaaggaa cctgatgctt taactttgct 1500 ggccccagcc gctggagaca caatcatatc tttagatttt ggcagcaacg acacagaaac 1560 tgatgaccag caacttgagg aagtaccatt atataatgat gtaatgctcc cctcacccaa 1620 cgaaaaatta cagaatataa atttggcaat gtctccatta cccaccgctg aaacgccaaa 1680 gccacttcga agtagtgctg accctgcact caatcaagaa gttgcattaa aattagaacc 1740 aaatccagag tcactggaac tttcttttac catgccccag attcaggatc agacacctag 1800 tccttccgat ggaagcacta gacaaagttc acctgagcct aatagtccca gtgaatattg 1860 tttttatgtg gatagtgata tggtcaatga attcaagttg gaattggtag aaaaactttt 1920 tgctgaagac acagaagcaa agaacccatt ttctactcag gacacagatt tagacttgga 1980 gatgttagct ccctatatcc caatggatga tgacttccag ttacgttcct tcgatcagtt 2040 gtcaccatta gaaagcagtt ccgcaagccc tgaaagcgca agtcctcaaa gcacagttac 2100 agtattccag cagactcaaa tacaagaacc tactgctaat gccaccacta ccactgccac 2160 cactgatgaa ttaaaaacag tgacaaaaga ccgtatggaa gacattaaaa tattgattgc 2220 atctccatct cctacccaca tacataaaga aactactagt gccacatcat caccatatag 2280 agatactcaa agtcggacag cctcaccaaa cagagcagga aaaggagtca tagaacagac 2340 agaaaaatct catccaagaa gccctaacgt gttatctgtc gctttgagtc aaagaactac 2400 agttcctgag gaagaactaa atccaaagat actagctttg cagaatgctc agagaaagcg 2460 aaaaatggaa catgatggtt cactttttca agcagtagga attggaacat tattacagca 2520 gccagacgat catgcagcta ctacatcact ttcttggaaa cgtgtaaaag gatgcaaatc 2580 tagtgaacag aatggaatgg agcaaaagac aattatttta ataccctctg atttagcatg 2640 tagactgctg gggcaatcaa tggatgaaag tggattacca cagctgacca gttatgattg 2700 tgaagttaat gctcctatac aaggcagcag aaacctactg cagggtgaag aattactcag 2760 agctttggat caagttaact gagctttttc ttaatttcat tccttttttt ggacactggt 2820 ggctcattac ctaaagcagt ctatttatat tttctacatc taattttaga agcctggcta 2880 caatactgca caaacttggt tagttcaatt ttgatcccct ttctacttaa tttacattaa 2940 tgctcttttt tagtatgttc tttaatgctg gatcacagac agctcatttt ctcagttttt 3000 tggtatttaa accattgcat tgcagtagca tcattttaaa aaatgcacct ttttatttat 3060 ttatttttgg ctagggagtt tatccctttt tcgaattatt tttaagaaga tgccaatata 3120 atttttgtaa gaaggcagta acctttcatc atgatcatag gcagttgaaa aatttttaca 3180 cctttttttt cacattttac ataaataata atgctttgcc agcagtacgt ggtagccaca 3240 attgcacaat atattttctt aaaaaatacc agcagttact catggaatat attctgcgtt 3300 tataaaacta gtttttaaga agaaattttt tttggcctat gaaattgtta aacctggaac 3360 atgacattgt taatcatata ataatgattc ttaaatgctg tatggtttat tatttaaatg 3420 ggtaaagcca tttacataat atagaaagat atgcatatat ctagaaggta tgtggcattt 3480 atttggataa aattctcaat tcagagaaat catctgatgt ttctatagtc actttgccag 3540 ctcaaaagaa aacaataccc tatgtagttg tggaagttta tgctaatatt gtgtaactga 3600 tattaaacct aaatgttctg cctaccctgt tggtataaag atattttgag cagactgtaa 3660 acaagaaaaa aaaaatcatg cattcttagc aaaattgcct agtatgttaa tttgctcaaa 3720 atacaatgtt tgattttatg cactttgtcg ctattaacat cctttttttc atgtagattt 3780 caataattga gtaattttag aagcattatt ttaggaatat atagttgtca cagtaaatat 3840 cttgtttttt ctatgtacat tgtacaaatt tttcattcct tttgctcttt gtggttggat 3900 ctaacactaa ctgtattgtt ttgttacatc aaataaacat cttctgtgga ccaggcaaaa 3960 aaaaaaaaaa aaaaaaaaa 3979 <210> 44 <211> 4082 <212> DNA <213> homo sapiens <400> 44 gcgcgcgccg gcctgggcag gcgagcgggc gcgctcccgc cccctctccc ctccccgcgc 60 gcccgagcgc gcctccgccc ttgcccgccc cctgacgctg cctcagctcc tcagtgcaca 120 gtgctgcctc gtctgagggg acaggaggat caccctcttc gtcgcttcgg ccagtgtgtc 180 gggctgggcc ctgacaagcc acctgaggag aggctcggag ccgggcccgg accccggcga 240 ttgccgcccg cttctctcta gtctcacgag gggtttcccg cctcgcaccc ccacctctgg 300 acttgccttt ccttctcttc tccgcgtgtg gagggagcca gcgcttaggc cggagcgagc 360 ctgggggccg cccgccgtga agacatcgcg gggaccgatt caccatggag ggcgccggcg 420 gcgcgaacga caagaaaaag ataagttctg aacgtcgaaa agaaaagtct cgagatgcag 480 ccagatctcg gcgaagtaaa gaatctgaag ttttttatga gcttgctcat cagttgccac 540 ttccacataa tgtgagttcg catcttgata aggcctctgt gatgaggctt accatcagct 600 atttgcgtgt gaggaaactt ctggatgctg gtgatttgga tattgaagat gacatgaaag 660 cacagatgaa ttgcttttat ttgaaagcct tggatggttt tgttatggtt ctcacagatg 720 atggtgacat gatttacatt tctgataatg tgaacaaata catgggatta actcagtttg 780 aactaactgg acacagtgtg tttgatttta ctcatccatg tgaccatgag gaaatgagag 840 aaatgcttac acacagaaat ggccttgtga aaaagggtaa agaacaaaac acacagcgaa 900 gcttttttct cagaatgaag tgtaccctaa ctagccgagg aagaactatg aacataaagt 960 ctgcaacatg gaaggtattg cactgcacag gccacattca cgtatatgat accaacagta 1020 accaacctca gtgtgggtat aagaaaccac ctatgacctg cttggtgctg atttgtgaac 1080 ccattcctca cccatcaaat attgaaattc ctttagatag caagactttc ctcagtcgac 1140 acagcctgga tatgaaattt tcttattgtg atgaaagaat taccgaattg atgggatatg 1200 agccagaaga acttttaggc cgctcaattt atgaatatta tcatgctttg gactctgatc 1260 atctgaccaa aactcatcat gatatgttta ctaaaggaca agtcaccaca ggacagtaca 1320 ggatgcttgc caaaagaggt ggatatgtct gggttgaaac tcaagcaact gtcatatata 1380 acaccaagaa ttctcaacca cagtgcattg tatgtgtgaa ttacgttgtg agtggtatta 1440 ttcagcacga cttgattttc tcccttcaac aaacagaatg tgtccttaaa ccggttgaat 1500 cttcagatat gaaaatgact cagctattca ccaaagttga atcagaagat acaagtagcc 1560 tctttgacaa acttaagaag gaacctgatg ctttaacttt gctggcccca gccgctggag 1620 acacaatcat atctttagat tttggcagca acgacacaga aactgatgac cagcaacttg 1680 aggaagtacc attatataat gatgtaatgc tcccctcacc caacgaaaaa ttacagaata 1740 taaatttggc aatgtctcca ttacccaccg ctgaaacgcc aaagccactt cgaagtagtg 1800 ctgaccctgc actcaatcaa gaagttgcat taaaattaga accaaatcca gagtcactgg 1860 aactttcttt taccatgccc cagattcagg atcagacacc tagtccttcc gatggaagca 1920 ctagacaaag ttcacctgag cctaatagtc ccagtgaata ttgtttttat gtggatagtg 1980 atatggtcaa tgaattcaag ttggaattgg tagaaaaact ttttgctgaa gacacagaag 2040 caaagaaccc attttctact caggacacag atttagactt ggagatgtta gctccctata 2100 tcccaatgga tgatgacttc cagttacgtt ccttcgatca gttgtcacca ttagaaagca 2160 gttccgcaag ccctgaaagc gcaagtcctc aaagcacagt tacagtattc cagcagactc 2220 aaatacaaga acctactgct aatgccacca ctaccactgc caccactgat gaattaaaaa 2280 cagtgacaaa agaccgtatg gaagacatta aaatattgat tgcatctcca tctcctaccc 2340 acatacataa agaaactact agtgccacat catcaccata tagagatact caaagtcgga 2400 cagcctcacc aaacagagca ggaaaaggag tcatagaaca gacagaaaaa tctcatccaa 2460 gaagccctaa cgtgttatct gtcgctttga gtcaaagaac tacagttcct gaggaagaac 2520 taaatccaaa gatactagct ttgcagaatg ctcagagaaa gcgaaaaatg gaacatgatg 2580 gttcactttt tcaagcagta ggaattggaa cattattaca gcagccagac gatcatgcag 2640 ctactacatc actttcttgg aaacgtgtaa aaggatgcaa atctagtgaa cagaatggaa 2700 tggagcaaaa gacaattatt ttaataccct ctgatttagc atgtagactg ctggggcaat 2760 caatggatga aagtggatta ccacagctga ccagttatga ttgtgaagtt aatgctccta 2820 tacaaggcag cagaaaccta ctgcagggtg aagaattact cagagctttg gatcaagtta 2880 actgagcttt ttcttaattt cattcctttt tttggacact ggtggctcat tacctaaagc 2940 agtctattta tattttctac atctaatttt agaagcctgg ctacaatact gcacaaactt 3000 ggttagttca attttgatcc cctttctact taatttacat taatgctctt ttttagtatg 3060 ttctttaatg ctggatcaca gacagctcat tttctcagtt ttttggtatt taaaccattg 3120 cattgcagta gcatcatttt aaaaaatgca cctttttatt tatttatttt tggctaggga 3180 gtttatccct ttttcgaatt atttttaaga agatgccaat ataatttttg taagaaggca 3240 gtaacctttc atcatgatca taggcagttg aaaaattttt acaccttttt tttcacattt 3300 tacataaata ataatgcttt gccagcagta cgtggtagcc acaattgcac aatatatttt 3360 cttaaaaaat accagcagtt actcatggaa tatattctgc gtttataaaa ctagttttta 3420 agaagaaatt ttttttggcc tatgaaattg ttaaacctgg aacatgacat tgttaatcat 3480 ataataatga ttcttaaatg ctgtatggtt tattatttaa atgggtaaag ccatttacat 3540 aatatagaaa gatatgcata tatctagaag gtatgtggca tttatttgga taaaattctc 3600 aattcagaga aatcatctga tgtttctata gtcactttgc cagctcaaaa gaaaacaata 3660 ccctatgtag ttgtggaagt ttatgctaat attgtgtaac tgatattaaa cctaaatgtt 3720 ctgcctaccc tgttggtata aagatatttt gagcagactg taaacaagaa aaaaaaaatc 3780 atgcattctt agcaaaattg cctagtatgt taatttgctc aaaatacaat gtttgatttt 3840 atgcactttg tcgctattaa catccttttt ttcatgtaga tttcaataat tgagtaattt 3900 tagaagcatt attttaggaa tatatagttg tcacagtaaa tatcttgttt tttctatgta 3960 cattgtacaa atttttcatt ccttttgctc tttgtggttg gatctaacac taactgtatt 4020 gttttgttac atcaaataaa catcttctgt ggaccaggca aaaaaaaaaa aaaaaaaaaa 4080 aa 4082 <210> 45 <211> 4095 <212> DNA <213> homo sapiens <400> 45 agacagccag ttcctctccc gccgcgccgg gccgcgctgc cgctcgctcc ccggccgtgg 60 cgcctccggg ccagacgcgc tgcagcctcc agcccgcggc aagcggggcg gccgcgccac 120 ccccggcccc gcgccagcag cccctcgccg cgcgtccagc gttcccggcc agcagcctcc 180 ccatacgcag gtcctgctgg gccgccccgt cgcgcccccc actctgaact caagtcaccg 240 tggagctccg ccgccccgaa actttcaccg cgagcgggaa atatgggatg tataaaatca 300 aaagggaaag acagcttgag tgacgatgga gtagatttga agactcaacc agttccagaa 360 tctcagcttt tacctggaca gaggtttcaa actaaagatc cagaggaaca aggagacatt 420 gtggtagcct tgtaccccta tgatggcatc cacccggacg acttgtcttt caagaaagga 480 gagaagatga aagtcctgga ggagcatgga gaatggtgga aagcaaagtc ccttttaaca 540 aaaaaagaag gcttcatccc cagcaactat gtggccaaac tcaacacctt agaaacagaa 600 gagtggtttt tcaaggatat aaccaggaag gacgcagaaa ggcagctttt ggcaccagga 660 aatagcgctg gagctttcct tattagagaa agtgaaacat taaaaggaag cttctctctg 720 tctgtcagag actttgaccc tgtgcatggt gatgttatta agcactacaa aattagaagt 780 ctggataatg ggggctatta catctctcca cgaatcactt ttccctgtat cagcgacatg 840 attaaacatt accaaaagca ggcagatggc ttgtgcagaa gattggagaa ggcttgtatt 900 agtcccaagc cacagaagcc atgggataaa gatgcctggg agatcccccg ggagtccatc 960 aagttggtga aaaggcttgg cgctgggcag tttggggaag tctggatggg ttactataac 1020 aacagtacca aggtggctgt gaaaaccctg aagccaggaa ctatgtctgt gcaagccttc 1080 ctggaagaag ccaacctcat gaagaccctg cagcatgaca agctcgtgag gctctacgct 1140 gtggtcacca gggaggagcc catttacatc atcaccgagt acatggccaa gggcagtttg 1200 ctggatttcc tgaagagcga tgaaggtggc aaagtgctgc ttccaaagct cattgacttt 1260 tctgctcaga ttgcagaggg aatggcatac atcgagcgga agaactacat tcaccgggac 1320 ctgcgagcag ctaatgttct ggtctccgag tcactcatgt gcaaaattgc agattttggc 1380 cttgctagag taattgaaga taatgagtac acagcaaggg aaggtgctaa gttccctatt 1440 aagtggacgg ctccagaagc aatcaacttt ggatgtttca ctattaagtc tgatgtgtgg 1500 tcctttggaa tcctcctata cgaaattgtc acctatggga aaattcccta cccagggaga 1560 actaatgccg acgtgatgac cgccctgtcc cagggctaca ggatgccccg tgtggagaac 1620 tgcccagatg agctctatga cattatgaaa atgtgctgga aagaaaaggc agaagagaga 1680 ccaacgtttg actacttaca gagcgtcctg gatgatttct acacagccac ggaagggcaa 1740 taccagcagc agccttagag cacagggaga cccgtccatt tggcaggggt ggctgcctca 1800 tttagagagg aaaagtaacc atcactggtt gcacttatga tttcatgtgc ggggatcatc 1860 tgccgtgcct ggatcctgaa atagaggcta aattactcag gaagaacacc ctctaaatgg 1920 gaaagtattc tgtactctta gatggattct ccactcagtt gcaacttgga cttgtcctca 1980 gcagctggta atcttgctct gcttgacaac atctgagtgc agccgtttga gaagaaaaca 2040 tctattctct ccaaaaatgc acccaactag ctctatgttt acaaatggac ataggactca 2100 aagtttcaga gaccattgca atgaatcccc aataattgca gaactaaact catttataaa 2160 gctaaaataa ccggatatat acatagcatg acatttcttt gtgctttggc ttacttgttt 2220 aaaaaaaaaa aaaaactaat ccaacctgtt agattttgca ggtgaagtca gcagcttaaa 2280 aatgtctttc ccagatttca atgatttttt tccccctacc tcccaaaatc tgagactgtt 2340 aaaacatttt tcttctatga acactgctca gacctgctag acatgccata ggagtggcgt 2400 gcacatctct ctctcttcca gcaggaggag cccgtgagca cgcacagctg ccctgtctgc 2460 tcacccgaag gcaccgggct cacctggacc tcccaggaaa gggagaagag cctcagaaac 2520 tgctctgtgt ttagaaggaa tatttttaag agtccagctt tttcatttcc acaatttcct 2580 atatccagat ttgttttgac aatgtagttt ggaagaacta agattctaat ctctgaagaa 2640 ccttataggg ccttctaaaa cataagagtt tcctttgttg cttcaaatat ttgaacatta 2700 tgttaaagat caagtattaa ttttagttgt actctagaaa gctaaagtgc cacattcggg 2760 gctattttta tgattcagca atcttttcta aattgtgtag catgtgtatg agactattta 2820 tacccaagga tatgaaggaa cataagtgac tacaaggctc taataagcca cggtggcagg 2880 aggttcaagc ggttctgttc actaaatttt tctcctgtaa gctttgaatg gaaacttctg 2940 tatcacatga tgtgtttcac ttatgctgtt gtgtatatac ctaatatttc tatttttgat 3000 tttattttaa tacacctcgt ccaataacat ctcaagcttt ttatttgcat ttacattttc 3060 agctgtggtc agtgtaaaaa ttggtcatca gctgggggcg gggtggttag aagtgattca 3120 acagagctac atgctttaaa cttgcccaag ttctacctcc ttcctttgaa catttcagat 3180 tggagaacca aggagttgat tgcctgaaca cctgaacatc cgtttatggg ggccagatag 3240 aatttgtttt caaataggct taacaggcat cattaaaatt tcattctgtg tgttttgttt 3300 aggcttgagg tgcttagaag atgggataaa atattctact tttttctaaa ttttaacttt 3360 gtttcctatg tgattttttt aaatgtcctt tctaaaatat tctaaaatta ttgattcaca 3420 agtgccatgt tcagaactat agaatattac tgttacataa tgtctgcaca gctggtccct 3480 tgattcagtg gtaaggtttt tgtgtacacc cccctgcttg cattttattt cagaaccaca 3540 agtattaccc aatatgttac atggagagga actataaaga atccctaagg caaaaagaag 3600 tctctagaaa atgactagag gttttttttt tagcataaca aatttattta aagaaaatta 3660 ttaaatttat cttcgccttg ttttgcttct cccagttcct cctcttcttg ccattttcca 3720 cttgtctttc cctcccaatc aagcctgtga tccttacctc catgtgggcc cttcaccagc 3780 ttgggcctca tctctggtgt ccagcatgtg tggaagtcac acgttccctt gatgaacagc 3840 acacacagtc tccttactta gctataggtt tccagcctcc ctgtgacaga caggcataat 3900 gaggggctga ataggtgttt gtagcatttt cgggtatcca gtggtgtgca aaatggctca 3960 tgtcatcaca cctcaggtta ttgtagagaa ctggaaagac agaatccata ctccctaccg 4020 ccaagattct gacttagctg ttgtgcagcg ggagatgtat gtcagtctat tttaaaagct 4080 tctccagtca gctag 4095 <210> 46 <211> 4158 <212> DNA <213> homo sapiens <400> 46 agacagccag ttcctctccc gccgcgccgg gccgcgctgc cgctcgctcc ccggccgtgg 60 cgcctccggg ccagacgcgc tgcagcctcc agcccgcggc aagcggggcg gccgcgccac 120 ccccggcccc gcgccagcag cccctcgccg cgcgtccagc gttcccggcc agcagcctcc 180 ccatacgcag gtcctgctgg gccgccccgt cgcgcccccc actctgaact caagtcaccg 240 tggagctccg ccgccccgaa actttcaccg cgagcgggaa atatgggatg tataaaatca 300 aaagggaaag acagcttgag tgacgatgga gtagatttga agactcaacc agtacgtaat 360 actgaaagaa ctatttatgt gagagatcca acgtccaata aacagcaaag gccagttcca 420 gaatctcagc ttttacctgg acagaggttt caaactaaag atccagagga acaaggagac 480 attgtggtag ccttgtaccc ctatgatggc atccacccgg acgacttgtc tttcaagaaa 540 ggagagaaga tgaaagtcct ggaggagcat ggagaatggt ggaaagcaaa gtccctttta 600 acaaaaaaag aaggcttcat ccccagcaac tatgtggcca aactcaacac cttagaaaca 660 gaagagtggt ttttcaagga tataaccagg aaggacgcag aaaggcagct tttggcacca 720 ggaaatagcg ctggagcttt ccttattaga gaaagtgaaa cattaaaagg aagcttctct 780 ctgtctgtca gagactttga ccctgtgcat ggtgatgtta ttaagcacta caaaattaga 840 agtctggata atgggggcta ttacatctct ccacgaatca cttttccctg tatcagcgac 900 atgattaaac attaccaaaa gcaggcagat ggcttgtgca gaagattgga gaaggcttgt 960 attagtccca agccacagaa gccatgggat aaagatgcct gggagatccc ccgggagtcc 1020 atcaagttgg tgaaaaggct tggcgctggg cagtttgggg aagtctggat gggttactat 1080 aacaacagta ccaaggtggc tgtgaaaacc ctgaagccag gaactatgtc tgtgcaagcc 1140 ttcctggaag aagccaacct catgaagacc ctgcagcatg acaagctcgt gaggctctac 1200 gctgtggtca ccagggagga gcccatttac atcatcaccg agtacatggc caagggcagt 1260 ttgctggatt tcctgaagag cgatgaaggt ggcaaagtgc tgcttccaaa gctcattgac 1320 ttttctgctc agattgcaga gggaatggca tacatcgagc ggaagaacta cattcaccgg 1380 gacctgcgag cagctaatgt tctggtctcc gagtcactca tgtgcaaaat tgcagatttt 1440 ggccttgcta gagtaattga agataatgag tacacagcaa gggaaggtgc taagttccct 1500 attaagtgga cggctccaga agcaatcaac tttggatgtt tcactattaa gtctgatgtg 1560 tggtcctttg gaatcctcct atacgaaatt gtcacctatg ggaaaattcc ctacccaggg 1620 agaactaatg ccgacgtgat gaccgccctg tcccagggct acaggatgcc ccgtgtggag 1680 aactgcccag atgagctcta tgacattatg aaaatgtgct ggaaagaaaa ggcagaagag 1740 agaccaacgt ttgactactt acagagcgtc ctggatgatt tctacacagc cacggaaggg 1800 caataccagc agcagcctta gagcacaggg agacccgtcc atttggcagg ggtggctgcc 1860 tcatttagag aggaaaagta accatcactg gttgcactta tgatttcatg tgcggggatc 1920 atctgccgtg cctggatcct gaaatagagg ctaaattact caggaagaac accctctaaa 1980 tgggaaagta ttctgtactc ttagatggat tctccactca gttgcaactt ggacttgtcc 2040 tcagcagctg gtaatcttgc tctgcttgac aacatctgag tgcagccgtt tgagaagaaa 2100 acatctattc tctccaaaaa tgcacccaac tagctctatg tttacaaatg gacataggac 2160 tcaaagtttc agagaccatt gcaatgaatc cccaataatt gcagaactaa actcatttat 2220 aaagctaaaa taaccggata tatacatagc atgacatttc tttgtgcttt ggcttacttg 2280 tttaaaaaaa aaaaaaaact aatccaacct gttagatttt gcaggtgaag tcagcagctt 2340 aaaaatgtct ttcccagatt tcaatgattt ttttccccct acctcccaaa atctgagact 2400 gttaaaacat ttttcttcta tgaacactgc tcagacctgc tagacatgcc ataggagtgg 2460 cgtgcacatc tctctctctt ccagcaggag gagcccgtga gcacgcacag ctgccctgtc 2520 tgctcacccg aaggcaccgg gctcacctgg acctcccagg aaagggagaa gagcctcaga 2580 aactgctctg tgtttagaag gaatattttt aagagtccag ctttttcatt tccacaattt 2640 cctatatcca gatttgtttt gacaatgtag tttggaagaa ctaagattct aatctctgaa 2700 gaaccttata gggccttcta aaacataaga gtttcctttg ttgcttcaaa tatttgaaca 2760 ttatgttaaa gatcaagtat taattttagt tgtactctag aaagctaaag tgccacattc 2820 ggggctattt ttatgattca gcaatctttt ctaaattgtg tagcatgtgt atgagactat 2880 ttatacccaa ggatatgaag gaacataagt gactacaagg ctctaataag ccacggtggc 2940 aggaggttca agcggttctg ttcactaaat ttttctcctg taagctttga atggaaactt 3000 ctgtatcaca tgatgtgttt cacttatgct gttgtgtata tacctaatat ttctattttt 3060 gattttattt taatacacct cgtccaataa catctcaagc tttttatttg catttacatt 3120 ttcagctgtg gtcagtgtaa aaattggtca tcagctgggg gcggggtggt tagaagtgat 3180 tcaacagagc tacatgcttt aaacttgccc aagttctacc tccttccttt gaacatttca 3240 gattggagaa ccaaggagtt gattgcctga acacctgaac atccgtttat gggggccaga 3300 tagaatttgt tttcaaatag gcttaacagg catcattaaa atttcattct gtgtgttttg 3360 tttaggcttg aggtgcttag aagatgggat aaaatattct acttttttct aaattttaac 3420 tttgtttcct atgtgatttt tttaaatgtc ctttctaaaa tattctaaaa ttattgattc 3480 acaagtgcca tgttcagaac tatagaatat tactgttaca taatgtctgc acagctggtc 3540 ccttgattca gtggtaaggt ttttgtgtac acccccctgc ttgcatttta tttcagaacc 3600 acaagtatta cccaatatgt tacatggaga ggaactataa agaatcccta aggcaaaaag 3660 aagtctctag aaaatgacta gaggtttttt ttttagcata acaaatttat ttaaagaaaa 3720 ttattaaatt tatcttcgcc ttgttttgct tctcccagtt cctcctcttc ttgccatttt 3780 ccacttgtct ttccctccca atcaagcctg tgatccttac ctccatgtgg gcccttcacc 3840 agcttgggcc tcatctctgg tgtccagcat gtgtggaagt cacacgttcc cttgatgaac 3900 agcacacaca gtctccttac ttagctatag gtttccagcc tccctgtgac agacaggcat 3960 aatgaggggc tgaataggtg tttgtagcat tttcgggtat ccagtggtgt gcaaaatggc 4020 tcatgtcatc acacctcagg ttattgtaga gaactggaaa gacagaatcc atactcccta 4080 ccgccaagat tctgacttag ctgttgtgca gcgggagatg tatgtcagtc tattttaaaa 4140 gcttctccag tcagctag 4158 <210> 47 <211> 1413 <212> DNA <213> homo sapiens <400> 47 ttgtgattgt ttttagtttg ttagctgcct ggagtgttat tttaagaaag cagaagcacc 60 atcatttgca cactccttat agatcacaca ccttaaccct gacttttttt gctccagttt 120 ttcagaagaa gtgaagtcaa gatgaagaac catttgcttt tctggggagt cctggcggtt 180 tttattaagg ctgttcatgt gaaagcccaa gaagatgaaa ggattgttct tgttgacaac 240 aaatgtaagt gtgcccggat tacttccagg atcatccgtt cttccgaaga tcctaatgag 300 gacattgtgg agagaaacat ccgaattatt gttcctctga acaacaggga gaatatctct 360 gatcccacct caccattgag aaccagattt gtgtaccatt tgtctgacct ctgtaaaaaa 420 tgtgatccta cagaagtgga gctggataat cagatagtta ctgctaccca gagcaatatc 480 tgtgatgaag acagtgctac agagacctgc tacacttatg acagaaacaa gtgctacaca 540 gctgtggtcc cactcgtata tggtggtgag accaaaatgg tggaaacagc cttaacccca 600 gatgcctgct atcctgacta atttaagtca ttgctgactg catagctctt tttcttgaga 660 ggctctccat tttgattcag aaagttagca tatttattac caatgaattt gaaaccaggg 720 cttttttttt tttttgggtg atgtaaaacc aactccctgc caccaaaata attaaaatag 780 tcacattgtt atctttatta ggtaatcact tcttaattat atgttcatac tctaagtatc 840 aaaatcttcc aattatcatg ctcacctgaa agaggtatgc tctcttagga atacagtttc 900 tagcattaaa caaataaaca aggggagaaa ataaaactca aggactgaaa atcaggaggt 960 gtaataaaat gttcctcgca ttcccccccg cttttttttt tttttttgac tttgccttgg 1020 agagccagag cttccgcatt ttctttacta ttctttttaa aaaaagtttc actgtgtaga 1080 gaacatatat gcataaacat aggtcaatta tatgtctcca ttagaaaaat aataattgga 1140 aaacatgttc tagaactagt tacaaaaata atttaaggtg aaatctctaa tatttataaa 1200 agtagcaaaa taaatgcata attaaaatat atttggacat aacagacttg gaagcagatg 1260 atacagactt ctttttttca taatcaggtt agtgtaagaa attgccattt gaaacaatcc 1320 attttgtaac tgaaccttat gaaatatatg tatttcatgg tacgtattct ctagcacagt 1380 ctgagcaatt aaatagattc ataagcataa aaa 1413 <210> 48 <211> 4778 <212> DNA <213> homo sapiens <400> 48 gggaggccga ctgagcagga gtcgtccgct tatagtggag gctgctagga gccggtcaga 60 ggcatcgaga gtaaacatga ggttacgatc ctgggaggac ttaatgaatt tgtagtgaag 120 ttttatggac cacaaggaac accatatgaa ggcggagtat ggaaagttag agtggaccta 180 cctgataaat accctttcaa atctccatct ataggattca tgaataaaat tttccatccc 240 aacattgatg aagcgtcagg aactgtgtgt ctagatgtaa ttaatcaaac ttggacagct 300 ctctatgatc ttaccaatat atttgagtcc ttcctgcctc agttattggc ctatcctaac 360 cccatagatc ctctcaatgg tgacgctgca gccatgtacc tccaccgacc agaagaatac 420 aagcagaaaa ttaaagagta catccagaaa tacgccacgg aggaggcgct gaaagaacag 480 gaagagggta ccggggacag ctcatcggag agctctatgt ctgacttttc cgaagatgag 540 gcccaggata tggagttgta gtagaaaaag cacctgcttt tcagaaagac tattatttcc 600 taaccatgag aagcagacta taatattcat atttaaacaa agcaattttt tttattacta 660 aacaaggttt ttatgaataa tagcattgat atatatatat tatatatcac cctttagatc 720 ttgatttctt ggtcatttct caacctgagg tgcatagcat attcccacat tccatttggt 780 agcaatatgc ggtctgaatg catgcattca tgagtccatg tggccaagtc agcctgtgtg 840 ctactgaact gtcgaaggaa atagccgctc tgataggtag atgtgagtaa aaagaacagg 900 aaaaaattgc ttcttttatt ggtttccaaa gaaacaaacc aaaccaacca gctcttggat 960 gtgaagataa aatagtgctt ttttgaaatg gagaggaaaa acttggggag gaagaggcct 1020 gctgtggggg catcggagcc agccatgtaa gaatcagagc tgctccttcc tgtgaatcct 1080 aggtggccct atgtcttctg tggagttaca gtataaagca gggagctaat taagagtatt 1140 aaaacttaaa accatttttt gactctgatt ttaagtacat ttttatatgt cagttgctgc 1200 ccttcacact accaggccct gcagccacag tgttctgttg gagaaacttg gggaagtgtt 1260 ttctgaacca gttctttttc ttggggtaga gcgtgaaatc cagacctgtt tttgaaagga 1320 cagcacagga ggagaaaagt gactgggacg atgcttcctc tcatccaaaa cacatgcaga 1380 gtcacatcct catcctagtg tttggcagtt tgagaccgct accctgaact taagagcttt 1440 aaatatgagg gttgtgtttc tgggggggtt atttttttgg tgtgtgtgtg tgtgtattgt 1500 gcttagaaag gttgcagatt tcatcttcac ctaccaagag gcggccgcct ccttggacaa 1560 gccgctcatg gaccattaga cttgagaaga cgacccacgt ggtgactgca aagccctggg 1620 tacttgcctt catgttctgg tttggttttc cctttttctg ctgctcttgg cagcagcctg 1680 gtcatcatct gcttgtggga gtgggaaatg ggtattttag acccaacaca ggttctaaat 1740 ttaaaacaaa taataattgg aacaaataaa ggttcttgta cccagagtga ttctacatgg 1800 gaaaaacaaa ccagcttttt tcagagagtg accgaatagg aagaagggat tcagaaatat 1860 gatgtagtag aacatgccct gcaggaagaa aatgttttct ctcctgcgta tgttaagagg 1920 aaatcagttt aaaatgcctg ctaatcaaat gtcgactcag ctaaccatat gtccaggttg 1980 ctgcagagtt tctttcaaat ctgagtgttg cctgctgaac tcggagggga gtttggagaa 2040 attttagaca gcagctctgt gttctttttt tgccgcagcc aataagataa tagcagaatt 2100 agccaatcct aaaaccttct aaagacgatt tttgagcatc ccactgggat tatttaattt 2160 ttctttttga cgtgtgtttt tagtttagaa gtgctgtatt ccacaaggtt taagtcagtg 2220 aggttggaag ataccctatc ttttttattc aaaaagcaca atcaatcttt tgtttgaaaa 2280 tctatataaa gtacaacttg cttttagcat gattattttc ctaaataaaa agacaaagaa 2340 tttacttact ttatgttaat tacgggcatg aagcaaaagg ttttctttaa aaaaaaaaaa 2400 aagtgcagtg atgtagggct gtggttagtt aaccgtactg agttatccat ctagcatctg 2460 tggcttgctg gaagggtagt attaactatt taacatgtaa tggtgtactt cactcttacc 2520 tagcacgctg tcttctcatt gctttggggg agggagggtc tctctgctgg cactgtctaa 2580 cttgcttacc tgctgacttt gcagtttgct tgtgctatga catttattgt aggtgctatt 2640 tagggtaggc ttaaagtgct gggtggtgat ttgagttcaa acaataaaaa attgtatttt 2700 ttcaatattg tataaacaat agtgttctaa ttaccttaaa aaaaaataat gaccagttaa 2760 gaattgcttt tgatcttgtc aaaaaactga atagacccca gtttcgggaa ggtgtgtgag 2820 cagtgccatg actctgcccc ttacctaatc ccacatctct ctaatgataa gacattggct 2880 cgcctctgac cagagcccca gcaccagaga gcggaagatg cagaattgtc aaatgacctg 2940 ctgggggagg ttgtaggagt ttagcagatt tgagtgtggc tgcagagaga gagagtgtgt 3000 gtatgtgtgc acatgtgtga gagtgtgagc gagagtgtgt gtgtgtccat ctaagtgtgt 3060 gtgatgaagg tgggataagg ctcctctgtt agtgctggaa gctcctgtaa ttgccgcatg 3120 gatcccactg tgccctcttg ttctgtgcaa gtctgtcctg tctgggcact aaccttggtc 3180 ccatgcatgt ttatgttctg ggtggggctt tgcctctcca ctgggaaact gacttttgct 3240 gggttgaaca gagtccctta tgctttttgt cctctccctg cgcctgggag aggtgggagt 3300 aggagcccaa acacacaggt acagaaagat ctggaagaag gcctggcagt gaatccaagg 3360 actctgggcc cccaacaata gatggtagcg taagtctgga gcagcggtgt ttcaccacca 3420 aatgcctttc caggctgccc ttccaacact caggagagca tccagatccc tgggcagagg 3480 ctctacattc ttggctttag aggtggtggc agcggcagca ggtcagagcc acttctggcg 3540 gtttccctcc cctttttagt gcccatagtt tttggatcct cccttgagtt ttaccagcac 3600 aagccattct ttgcccctgt tcacataact gagctcaagc tcttgccaaa caccaacaag 3660 caagatggtt gcaacctggc aacattgaat ccaccaccct tgggctccct ctggaagccc 3720 cagcaccggg gggcttttgg gcacagggtc agtggtagcc atcttagaca ctgacatttg 3780 gctttgtcgt caatttcatc accctccttg aggttactgt gcagtttcaa ccagcatttt 3840 atcctagtga ggtcattatc aggagttgcc atatcatctc tccagtacct aacatttctc 3900 atccacttca aaagctgttc tgactgccag ctggctgatc taagctcctg aggaatgtct 3960 cctctcaaag gaatttttcc ctccaaaggc cccctgaagt cctagttggc attggcctgg 4020 cacatgcttt atgttaggcc tcccgttggg atggctgaga atcatgaaag acagatcctc 4080 cgctagcctc tgtgggtcaa gtttctggac accaagtctc tgggaactag tgtttgattt 4140 taaatggcat gtggcccttc cttgtttcag tgacttagaa aagtaaaagc catttaaaaa 4200 agttagcaag attttttatc gacttcccaa ctgggcttcc agccttgttg aatgaaatca 4260 tctatctctg attgggcgca acgaactgca tttctttgga cttctgaatc catgtttgtg 4320 ctttctctgg cccgtgaaca cctcggcgat tctgttaggg atgggatgag tgggaggaag 4380 ccctttgaga agggggagcc ggccctgtca tgcgcaggtt ttccactcat ctgaggaaga 4440 gccagggctc tgaatttagc ctaacactca tcttggctgt gggcttggga agaaatggcc 4500 attatttaca gattgtattt ggtacatatt gtgtgatact tgaaaagata aaagggactg 4560 ccagccccta actgaaatct gaagcttttt atcgcttatt tttcctcgcc ctgtctcctc 4620 ccttccacct ttctccttgc attgtgatga tctagtaggc acgtctgtca acaggacaca 4680 tgcctcctct gactataacc tcttaatagt tgtgtataat gaaaactgta aactttttta 4740 aataaacgtg tatatacctt ggcaaaaaaa aaaaaaaa 4778 <210> 49 <211> 5174 <212> DNA <213> homo sapiens <400> 49 agagcgaggc tggggtaggg aggccgactg agcaggagtc gtccgcttat agtggaggct 60 gctaggagcc ggtcagaggg tgagtgggga gcaggcgagc gagccacagc aggcaggagg 120 gagcgtcgcg cggcgcagag gagcgccggg gcagggccgc ggcggaacca cagccggaga 180 ggggcagccc gagccgggcg ccgcagggtc cccaccccca cccggccgga cagtgcccgg 240 tgttcccccg tgcggggggc ggcggcggcg gctgacggga ccgccgggac cgcgggggtg 300 ttgccacctc caccgaggag ccggcgcggc cgcgggctcc tcagagccgg ggccccgggc 360 ccgtgacaga cgggccgagg aagggagaga ggcggcggcg acaccatgtc atctcccagt 420 ccgggcaaga ggcggatgga cacggacgtg gtcaagctca tcgagagtaa acatgaggtt 480 acgatcctgg gaggacttaa tgaatttgta gtgaagtttt atggaccaca aggaacacca 540 tatgaaggcg gagtatggaa agttagagtg gacctacctg ataaataccc tttcaaatct 600 ccatctatag gattcatgaa taaaattttc catcccaaca ttgatgaagc gtcaggaact 660 gtgtgtctag atgtaattaa tcaaacttgg acagctctct atgatcttac caatatattt 720 gagtccttcc tgcctcagtt attggcctat cctaacccca tagatcctct caatggtgac 780 gctgcagcca tgtacctcca ccgaccagaa gaatacaagc agaaaattaa agagtacatc 840 cagaaatacg ccacggagga ggcgctgaaa gaacaggaag agggtaccgg ggacagctca 900 tcggagagct ctatgtctga cttttccgaa gatgaggccc aggatatgga gttgtagtag 960 aaaaagcacc tgcttttcag aaagactatt atttcctaac catgagaagc agactataat 1020 attcatattt aaacaaagca atttttttta ttactaaaca aggtttttat gaataatagc 1080 attgatatat atatattata tatcaccctt tagatcttga tttcttggtc atttctcaac 1140 ctgaggtgca tagcatattc ccacattcca tttggtagca atatgcggtc tgaatgcatg 1200 cattcatgag tccatgtggc caagtcagcc tgtgtgctac tgaactgtcg aaggaaatag 1260 ccgctctgat aggtagatgt gagtaaaaag aacaggaaaa aattgcttct tttattggtt 1320 tccaaagaaa caaaccaaac caaccagctc ttggatgtga agataaaata gtgctttttt 1380 gaaatggaga ggaaaaactt ggggaggaag aggcctgctg tgggggcatc ggagccagcc 1440 atgtaagaat cagagctgct ccttcctgtg aatcctaggt ggccctatgt cttctgtgga 1500 gttacagtat aaagcaggga gctaattaag agtattaaaa cttaaaacca ttttttgact 1560 ctgattttaa gtacattttt atatgtcagt tgctgccctt cacactacca ggccctgcag 1620 ccacagtgtt ctgttggaga aacttgggga agtgttttct gaaccagttc tttttcttgg 1680 ggtagagcgt gaaatccaga cctgtttttg aaaggacagc acaggaggag aaaagtgact 1740 gggacgatgc ttcctctcat ccaaaacaca tgcagagtca catcctcatc ctagtgtttg 1800 gcagtttgag accgctaccc tgaacttaag agctttaaat atgagggttg tgtttctggg 1860 ggggttattt ttttggtgtg tgtgtgtgtg tattgtgctt agaaaggttg cagatttcat 1920 cttcacctac caagaggcgg ccgcctcctt ggacaagccg ctcatggacc attagacttg 1980 agaagacgac ccacgtggtg actgcaaagc cctgggtact tgccttcatg ttctggtttg 2040 gttttccctt tttctgctgc tcttggcagc agcctggtca tcatctgctt gtgggagtgg 2100 gaaatgggta ttttagaccc aacacaggtt ctaaatttaa aacaaataat aattggaaca 2160 aataaaggtt cttgtaccca gagtgattct acatgggaaa aacaaaccag cttttttcag 2220 agagtgaccg aataggaaga agggattcag aaatatgatg tagtagaaca tgccctgcag 2280 gaagaaaatg ttttctctcc tgcgtatgtt aagaggaaat cagtttaaaa tgcctgctaa 2340 tcaaatgtcg actcagctaa ccatatgtcc aggttgctgc agagtttctt tcaaatctga 2400 gtgttgcctg ctgaactcgg aggggagttt ggagaaattt tagacagcag ctctgtgttc 2460 tttttttgcc gcagccaata agataatagc agaattagcc aatcctaaaa ccttctaaag 2520 acgatttttg agcatcccac tgggattatt taatttttct ttttgacgtg tgtttttagt 2580 ttagaagtgc tgtattccac aaggtttaag tcagtgaggt tggaagatac cctatctttt 2640 ttattcaaaa agcacaatca atcttttgtt tgaaaatcta tataaagtac aacttgcttt 2700 tagcatgatt attttcctaa ataaaaagac aaagaattta cttactttat gttaattacg 2760 ggcatgaagc aaaaggtttt ctttaaaaaa aaaaaaaagt gcagtgatgt agggctgtgg 2820 ttagttaacc gtactgagtt atccatctag catctgtggc ttgctggaag ggtagtatta 2880 actatttaac atgtaatggt gtacttcact cttacctagc acgctgtctt ctcattgctt 2940 tgggggaggg agggtctctc tgctggcact gtctaacttg cttacctgct gactttgcag 3000 tttgcttgtg ctatgacatt tattgtaggt gctatttagg gtaggcttaa agtgctgggt 3060 ggtgatttga gttcaaacaa taaaaaattg tattttttca atattgtata aacaatagtg 3120 ttctaattac cttaaaaaaa aataatgacc agttaagaat tgcttttgat cttgtcaaaa 3180 aactgaatag accccagttt cgggaaggtg tgtgagcagt gccatgactc tgccccttac 3240 ctaatcccac atctctctaa tgataagaca ttggctcgcc tctgaccaga gccccagcac 3300 cagagagcgg aagatgcaga attgtcaaat gacctgctgg gggaggttgt aggagtttag 3360 cagatttgag tgtggctgca gagagagaga gtgtgtgtat gtgtgcacat gtgtgagagt 3420 gtgagcgaga gtgtgtgtgt gtccatctaa gtgtgtgtga tgaaggtggg ataaggctcc 3480 tctgttagtg ctggaagctc ctgtaattgc cgcatggatc ccactgtgcc ctcttgttct 3540 gtgcaagtct gtcctgtctg ggcactaacc ttggtcccat gcatgtttat gttctgggtg 3600 gggctttgcc tctccactgg gaaactgact tttgctgggt tgaacagagt cccttatgct 3660 ttttgtcctc tccctgcgcc tgggagaggt gggagtagga gcccaaacac acaggtacag 3720 aaagatctgg aagaaggcct ggcagtgaat ccaaggactc tgggccccca acaatagatg 3780 gtagcgtaag tctggagcag cggtgtttca ccaccaaatg cctttccagg ctgcccttcc 3840 aacactcagg agagcatcca gatccctggg cagaggctct acattcttgg ctttagaggt 3900 ggtggcagcg gcagcaggtc agagccactt ctggcggttt ccctcccctt tttagtgccc 3960 atagtttttg gatcctccct tgagttttac cagcacaagc cattctttgc ccctgttcac 4020 ataactgagc tcaagctctt gccaaacacc aacaagcaag atggttgcaa cctggcaaca 4080 ttgaatccac cacccttggg ctccctctgg aagccccagc accggggggc ttttgggcac 4140 agggtcagtg gtagccatct tagacactga catttggctt tgtcgtcaat ttcatcaccc 4200 tccttgaggt tactgtgcag tttcaaccag cattttatcc tagtgaggtc attatcagga 4260 gttgccatat catctctcca gtacctaaca tttctcatcc acttcaaaag ctgttctgac 4320 tgccagctgg ctgatctaag ctcctgagga atgtctcctc tcaaaggaat ttttccctcc 4380 aaaggccccc tgaagtccta gttggcattg gcctggcaca tgctttatgt taggcctccc 4440 gttgggatgg ctgagaatca tgaaagacag atcctccgct agcctctgtg ggtcaagttt 4500 ctggacacca agtctctggg aactagtgtt tgattttaaa tggcatgtgg cccttccttg 4560 tttcagtgac ttagaaaagt aaaagccatt taaaaaagtt agcaagattt tttatcgact 4620 tcccaactgg gcttccagcc ttgttgaatg aaatcatcta tctctgattg ggcgcaacga 4680 actgcatttc tttggacttc tgaatccatg tttgtgcttt ctctggcccg tgaacacctc 4740 ggcgattctg ttagggatgg gatgagtggg aggaagccct ttgagaaggg ggagccggcc 4800 ctgtcatgcg caggttttcc actcatctga ggaagagcca gggctctgaa tttagcctaa 4860 cactcatctt ggctgtgggc ttgggaagaa atggccatta tttacagatt gtatttggta 4920 catattgtgt gatacttgaa aagataaaag ggactgccag cccctaactg aaatctgaag 4980 ctttttatcg cttatttttc ctcgccctgt ctcctccctt ccacctttct ccttgcattg 5040 tgatgatcta gtaggcacgt ctgtcaacag gacacatgcc tcctctgact ataacctctt 5100 aatagttgtg tataatgaaa actgtaaact tttttaaata aacgtgtata taccttggca 5160 aaaaaaaaaa aaaa 5174 <210> 50 <211> 1865 <212> DNA <213> homo sapiens <400> 50 gggttgatga cgtcagcgtt cgaattccat ggcggcgcgg cggcgacgga gcaccggcgg 60 cggcagggcg agagcattaa atgaaagcaa aagagttaat aatggcaaca cggctccaga 120 agactcttcc cctgccaaga aaactcgtag atgccagaga caggagtcga aaaagatgcc 180 tgtggctgga ggaaaagcta ataaggacag gacagaagac aagcaagatg aatctgtgaa 240 ggccttgctg ttaaagggca aagctcctgt ggacccagag tgtacagcca aggtggggaa 300 ggctcatgtg tattgtgaag gaaatgatgt ctatgatgtc atgctaaatc agaccaatct 360 ccagttcaac aacaacaagt actatctgat tcagctatta gaagatgatg cccagaggaa 420 cttcagtgtt tggatgagat ggggccgagt tgggaaaatg ggacagcaca gcctggtggc 480 ttgttcaggc aatctcaaca aggccaagga aatctttcag aagaaattcc ttgacaaaac 540 gaaaaacaat tgggaagatc gagaaaagtt tgagaaggtg cctggaaaat atgatatgct 600 acagatggac tatgccacca atactcagga tgaagaggaa acaaagaaag aggaatctct 660 taaatctccc ttgaagccag agtcacagct agatcttcgg gtacaggagt taataaagtt 720 gatctgtaat gttcaggcca tggaagaaat gatgatggaa atgaagtata ataccaagaa 780 agccccactt gggaagctga cagtggcaca aatcaaggca ggttaccagt ctcttaagaa 840 gattgaggat tgtattcggg ctggccagca tggacgagct ctcatggaag catgcaatga 900 attctacacc aggattccgc atgactttgg actccgtact cctccactaa tccggacaca 960 gaaggaactg tcagaaaaaa tacaattact agaggctttg ggagacattg aaattgctat 1020 taagctggtg aaaacagagc tacaaagccc agaacaccca ttggaccaac actatagaaa 1080 cctacattgt gccttgcgcc cccttgacca tgaaagttat gagttcaaag tgatttccca 1140 gtacctacaa tctacccatg ctcccacaca cagcgactat accatgacct tgctggattt 1200 gtttgaagtg gagaaggatg gtgagaaaga agccttcaga gaggaccttc ataacaggat 1260 gcttctatgg catggttcca ggatgagtaa ctgggtggga atcttgagcc atgggcttcg 1320 aattgcccca cctgaagctc ccatcacagg ttacatgttt gggaaaggaa tctactttgc 1380 tgacatgtct tccaagagtg ccaattactg ctttgcctct cgcctaaaga atacaggact 1440 gctgctctta tcagaggtag ctctaggtca gtgtaatgaa ctactagagg ccaatcctaa 1500 ggccgaagga ttgcttcaag gtaaacatag caccaagggg ctgggcaaga tggctcccag 1560 ttctgcccac ttcgtcaccc tgaatgggag tacagtgcca ttaggaccag caagtgacac 1620 aggaattctg aatccagatg gttataccct caactacaat gaatatattg tatataaccc 1680 caaccaggtc cgtatgcggt accttttaaa ggttcagttt aatttccttc agctgtggtg 1740 aatgttgata ttaaataaac cagagatctg atcttcaagc aagaaaataa gcagtgttgt 1800 acttgtgaat tttgtgatat tttatgtaat aaaaactgta caggtctaaa aaaaaaaaaa 1860 aaaaa 1865 <210> 51 <211> 1904 <212> DNA <213> homo sapiens <400> 51 gggttgatga cgtcagcgtt cgaattccat ggcggcgcgg cggcgacgga gcaccggcgg 60 cggcagggcg agagcattaa atgaaagcaa aagagttaat aatggcaaca cggctccaga 120 agactcttcc cctgccaaga aaactcgtag atgccagaga caggagtcga aaaagatgcc 180 tgtggctgga ggaaaagcta ataaggacag gacagaagac aagcaagatg gtatgccagg 240 aaggtcatgg gccagcaaaa gggtctctga atctgtgaag gccttgctgt taaagggcaa 300 agctcctgtg gacccagagt gtacagccaa ggtggggaag gctcatgtgt attgtgaagg 360 aaatgatgtc tatgatgtca tgctaaatca gaccaatctc cagttcaaca acaacaagta 420 ctatctgatt cagctattag aagatgatgc ccagaggaac ttcagtgttt ggatgagatg 480 gggccgagtt gggaaaatgg gacagcacag cctggtggct tgttcaggca atctcaacaa 540 ggccaaggaa atctttcaga agaaattcct tgacaaaacg aaaaacaatt gggaagatcg 600 agaaaagttt gagaaggtgc ctggaaaata tgatatgcta cagatggact atgccaccaa 660 tactcaggat gaagaggaaa caaagaaaga ggaatctctt aaatctccct tgaagccaga 720 gtcacagcta gatcttcggg tacaggagtt aataaagttg atctgtaatg ttcaggccat 780 ggaagaaatg atgatggaaa tgaagtataa taccaagaaa gccccacttg ggaagctgac 840 agtggcacaa atcaaggcag gttaccagtc tcttaagaag attgaggatt gtattcgggc 900 tggccagcat ggacgagctc tcatggaagc atgcaatgaa ttctacacca ggattccgca 960 tgactttgga ctccgtactc ctccactaat ccggacacag aaggaactgt cagaaaaaat 1020 acaattacta gaggctttgg gagacattga aattgctatt aagctggtga aaacagagct 1080 acaaagccca gaacacccat tggaccaaca ctatagaaac ctacattgtg ccttgcgccc 1140 ccttgaccat gaaagttatg agttcaaagt gatttcccag tacctacaat ctacccatgc 1200 tcccacacac agcgactata ccatgacctt gctggatttg tttgaagtgg agaaggatgg 1260 tgagaaagaa gccttcagag aggaccttca taacaggatg cttctatggc atggttccag 1320 gatgagtaac tgggtgggaa tcttgagcca tgggcttcga attgccccac ctgaagctcc 1380 catcacaggt tacatgtttg ggaaaggaat ctactttgct gacatgtctt ccaagagtgc 1440 caattactgc tttgcctctc gcctaaagaa tacaggactg ctgctcttat cagaggtagc 1500 tctaggtcag tgtaatgaac tactagaggc caatcctaag gccgaaggat tgcttcaagg 1560 taaacatagc accaaggggc tgggcaagat ggctcccagt tctgcccact tcgtcaccct 1620 gaatgggagt acagtgccat taggaccagc aagtgacaca ggaattctga atccagatgg 1680 ttataccctc aactacaatg aatatattgt atataacccc aaccaggtcc gtatgcggta 1740 ccttttaaag gttcagttta atttccttca gctgtggtga atgttgatat taaataaacc 1800 agagatctga tcttcaagca agaaaataag cagtgttgta cttgtgaatt ttgtgatatt 1860 ttatgtaata aaaactgtac aggtctaaaa aaaaaaaaaa aaaa 1904 <210> 52 <211> 3325 <212> DNA <213> homo sapiens <400> 52 ggggtccttg gctgggcggg gcttgctcgc ggtggcttgt ggctccttcc tgcggtgctt 60 ctctctttcg ctcaggcccg tggcgccgac aggatgggca agtgtcgtgg acttcgtact 120 gctaggaagc tccgtagtca ccgacgagac cagaagtggc atgataaaca gtataagaaa 180 gctcatttgg gcacagccct aaaggccaac ccttttggag gtgcttctca tgcaaaagga 240 atcgtgctgg aaaaagtagg agttgaagcc aaacagccaa attctgccat taggaagtgt 300 gtaagggtcc agctgatcaa gaatggcaag aaaatcacag cctttgtacc caatgacggt 360 tgcttgaact ttattgagga aaatgatgaa gttctggttg ctggatttgg tcgcaaaggt 420 catgctgttg gtgatattcc tggagtccgc tttaaggttg tcaaagtagc caatgtttct 480 cttttggccc tatacaaagg caagaaggaa agaccaagat cataaatatt aatggtgaaa 540 acactgtagt aataaatttt catatgccaa aaaatgtttg tatcttactg tcccctgttc 600 tcaccacgaa gatcatgttc attaccacca ccaccccccc ttattttttt tatcctaaac 660 cagcaaacgc aggacctgta ccaattttag gagacaataa gacagggttg tttcaggatt 720 ctctagagtt aataacattt gtaacctggc acagtttccc tcatcctgtg gaataagaaa 780 atgggataga tctggaataa atgtgcagta ttgtagtatt actttaagaa ctttaaggga 840 acttcaaaaa ctcactgaaa ttctagtgag atactttctt ttttattctt ggtattttcc 900 atatcgggtg caacacttca gttaccaaat ttcattgcac atagattatc ttaggtaccc 960 ttggaaatgc acattcttgt atccatctta caggggccca agatgataaa tagtaaactc 1020 aaaattgctc cccactctgt ttattattta aaggtgtcag gatctgtgtt gtaatgtgtc 1080 tacattaatg tgtttaggag aatacaggca ttggatcatt tagttgatgg aagtatatgc 1140 caggcaaggg agataaggta tacgacaaga ctgatgtttt cagtatcttc tcatgaggtt 1200 gtcagagacc ttcatgtctt caaagactag tcagcaaatg aagtggttta gtgtagagac 1260 aagattggtt gtgttttgat aatttaagct aggtattgag tacatgtgga ttttgctgtc 1320 cacaaatact tgtttcagag ttttcatgga tacagtggca tggttgaaat gaagctgtga 1380 gccttctgct ttaaatctga tgtaagaaac tcctgttaac aaatagtaag tatgggttaa 1440 ttagcccttt gatcaaagcc tagctttaca ttgtttagga tctttggaaa acaattggtt 1500 tggttgccca ctttccgtag gatcaagagc agaacctttc acatggcaca gaagaaccca 1560 ggttgcgctt catacctgca tattccagcc ttagcctgcc atttctctcc ttggcacttt 1620 gtgctccagc aacactggtc tcagttggtc atcctcaaac ttgggttcca tatccagcct 1680 caggacctct gttcctgtta ctatggttcc ttgcatgtcg cctgctctta ctaaagagct 1740 cgtgtgtttt ccagcacact tcggtttatc tcttgatgat gatgctagtc tctccctccg 1800 caagggcgga aaggctgcct gttggtttgt accagtgttt cctaacgtgt agctgcagtc 1860 agtatttggc taagctgttc ccaggggctc aacagatgct ttcggatgag ccttaactga 1920 cccaatcctt tgtgatgcgg gagagattgc taggcctcgc tcacctggcc agaaccaggg 1980 aaagaggccg cggttgcagc gcgattccag gccctgggcg tcaggcgcgg ggtgggcagc 2040 tctccccggg cggtggggcc cttgtgaccg cgaggcgggg cgcaccagga agggagtggg 2100 acagcgcggg cgcccaggga tgtggcctgg ttacctgcct tctctgatac gtcaagacac 2160 cttcaacaat ggcttgcagc tgtaccctgt tggctgcacc caggacgccc ttttcactgc 2220 taagcagtcc tacctgaggc ccaggggctg ccagattgac ccataaataa tctccggcgc 2280 ctcagatcca gaagctgctg agcctgatct tagtgccttc tcctttctct gtgtggcccc 2340 ccagcccctt tccccactgc cttgtgtcca aggccctttc cttcatgtat ccatggagga 2400 gagacaaaaa tacacatcaa taaaataaga tagggaatcc ataaatagac attcagaagt 2460 atggccaacg gatttatctt aaaaccaatg gaggaagaag agtttcaata aatgttgtgg 2520 acttccattt gtcaaagacc aaaacaaagg aaccccaacc ttacatgtaa tacaaactta 2580 actcaaaatg gatcatatat ctaaatgtaa aatggaaagc tataaaactg aaaacagact 2640 atctttacaa cctaggcgta ggtatagttt ttagacatta caccaaaagc acatgccgta 2700 aaagaaaaaa tagataaatt ggtggatttc attaaaatta aaaaactttt tctctctgaa 2760 aaatcctgtt aagctgggcg ctgtggttca tgcctgtaat cccagcactt tgggaggctg 2820 agttgggaag aaattaatag cttgaggcca ggagttcaag atcatcctgg gcagcaaagt 2880 catacactct tgagggaaga gagagacctt ctcatattgt tttatattgt tttatactca 2940 gtacctgttt taagaaaaaa acaaggaagt gaaatcaaag acaggcagcc cggcaccagg 3000 cctgaaacca gccctgggcc tgcctggcct aaacctagta gttaaaaatc aacttacgac 3060 ttagaacctg atgttatccg tagattccaa gcattgtata aaaaaattgt gaaactccct 3120 gttgtgttct gtaccagtgc atgaaacccc tgtcacatat cccctagatt gctcaatcaa 3180 tcacgaccct ttcatgtgaa atctttagtg ttgtgagccc ttaaaaggga cagaaattgt 3240 gcacttgagg agctcagatt ttaaggctgt agcttgccga tgctcccagc tgaataaagc 3300 ccttccttct acaaaaaaaa aaaaa 3325 <210> 53 <211> 1401 <212> DNA <213> homo sapiens <400> 53 ggctgggact ggctgagcct ggcgggaggc ggggtccgag tcaccgcctg ccgccgcgcc 60 cccggtttct ataaattgag cccgcagcct cccgcttcgc tctctgctcc tcctgttcga 120 cagtcagccg catcttcttt tgcgtcgcca gccgagccac atcgctcaga caccatgggg 180 aaggtgaagg tcggagtcaa cggatttggt cgtattgggc gcctggtcac cagggctgct 240 tttaactctg gtaaagtgga tattgttgcc atcaatgacc ccttcattga cctcaactac 300 atggtttaca tgttccaata tgattccacc catggcaaat tccatggcac cgtcaaggct 360 gagaacggga agcttgtcat caatggaaat cccatcacca tcttccagga gcgagatccc 420 tccaaaatca agtggggcga tgctggcgct gagtacgtcg tggagtccac tggcgtcttc 480 accaccatgg agaaggctgg ggctcatttg caggggggag ccaaaagggt catcatctct 540 gccccctctg ctgatgcccc catgttcgtc atgggtgtga accatgagaa gtatgacaac 600 agcctcaaga tcatcagcaa tgcctcctgc accaccaact gcttagcacc cctggccaag 660 gtcatccatg acaactttgg tatcgtggaa ggactcatga ccacagtcca tgccatcact 720 gccacccaga agactgtgga tggcccctcc gggaaactgt ggcgtgatgg ccgcggggct 780 ctccagaaca tcatccctgc ctctactggc gctgccaagg ctgtgggcaa ggtcatccct 840 gagctgaacg ggaagctcac tggcatggcc ttccgtgtcc ccactgccaa cgtgtcagtg 900 gtggacctga cctgccgtct agaaaaacct gccaaatatg atgacatcaa gaaggtggtg 960 aagcaggcgt cggagggccc cctcaagggc atcctgggct acactgagca ccaggtggtc 1020 tcctctgact tcaacagcga cacccactcc tccacctttg acgctggggc tggcattgcc 1080 ctcaacgacc actttgtcaa gctcatttcc tggtatgaca acgaatttgg ctacagcaac 1140 agggtggtgg acctcatggc ccacatggcc tccaaggagt aagacccctg gaccaccagc 1200 cccagcaaga gcacaagagg aagagagaga ccctcactgc tggggagtcc ctgccacact 1260 cagtccccca ccacactgaa tctcccctcc tcacagttgc catgtagacc ccttgaagag 1320 gggaggggcc tagggagccg caccttgtca tgtaccatca ataaagtacc ctgtgctcaa 1380 ccaaaaaaaa aaaaaaaaaa a 1401 <210> 54 <211> 1425 <212> DNA <213> homo sapiens <400> 54 gtgcgcagcg ggtgcatccc tgtccggatg ctgcgcctgc ggtagagcgg ccgccatgtt 60 gcaaccggga aggaaatgaa tgggcagccg ttaggaaagc ctgccggtga ctaaccctgc 120 gctcctgcct cgatgggtgg agtcgcgtgt ggcggggaag tcaggtggag cgaggctagc 180 tggcccgatt tctcctccgg gtgatgcttt tcctagatta ttctctgatt tggtcgtatt 240 gggcgcctgg tcaccagggc tgcttttaac tctggtaaag tggatattgt tgccatcaat 300 gaccccttca ttgacctcaa ctacatggtt tacatgttcc aatatgattc cacccatggc 360 aaattccatg gcaccgtcaa ggctgagaac gggaagcttg tcatcaatgg aaatcccatc 420 accatcttcc aggagcgaga tccctccaaa atcaagtggg gcgatgctgg cgctgagtac 480 gtcgtggagt ccactggcgt cttcaccacc atggagaagg ctggggctca tttgcagggg 540 ggagccaaaa gggtcatcat ctctgccccc tctgctgatg cccccatgtt cgtcatgggt 600 gtgaaccatg agaagtatga caacagcctc aagatcatca gcaatgcctc ctgcaccacc 660 aactgcttag cacccctggc caaggtcatc catgacaact ttggtatcgt ggaaggactc 720 atgaccacag tccatgccat cactgccacc cagaagactg tggatggccc ctccgggaaa 780 ctgtggcgtg atggccgcgg ggctctccag aacatcatcc ctgcctctac tggcgctgcc 840 aaggctgtgg gcaaggtcat ccctgagctg aacgggaagc tcactggcat ggccttccgt 900 gtccccactg ccaacgtgtc agtggtggac ctgacctgcc gtctagaaaa acctgccaaa 960 tatgatgaca tcaagaaggt ggtgaagcag gcgtcggagg gccccctcaa gggcatcctg 1020 ggctacactg agcaccaggt ggtctcctct gacttcaaca gcgacaccca ctcctccacc 1080 tttgacgctg gggctggcat tgccctcaac gaccactttg tcaagctcat ttcctggtat 1140 gacaacgaat ttggctacag caacagggtg gtggacctca tggcccacat ggcctccaag 1200 gagtaagacc cctggaccac cagccccagc aagagcacaa gaggaagaga gagaccctca 1260 ctgctgggga gtccctgcca cactcagtcc cccaccacac tgaatctccc ctcctcacag 1320 ttgccatgta gaccccttga agaggggagg ggcctaggga gccgcacctt gtcatgtacc 1380 atcaataaag taccctgtgc tcaaccaaaa aaaaaaaaaa aaaaa 1425 <210> 55 <211> 987 <212> DNA <213> homo sapiens <400> 55 aatataagtg gaggcgtcgc gctggcgggc attcctgaag ctgacagcat tcgggccgag 60 atgtctcgct ccgtggcctt agctgtgctc gcgctactct ctctttctgg cctggaggct 120 atccagcgta ctccaaagat tcaggtttac tcacgtcatc cagcagagaa tggaaagtca 180 aatttcctga attgctatgt gtctgggttt catccatccg acattgaagt tgacttactg 240 aagaatggag agagaattga aaaagtggag cattcagact tgtctttcag caaggactgg 300 tctttctatc tcttgtacta cactgaattc acccccactg aaaaagatga gtatgcctgc 360 cgtgtgaacc atgtgacttt gtcacagccc aagatagtta agtgggatcg agacatgtaa 420 gcagcatcat ggaggtttga agatgccgca tttggattgg atgaattcca aattctgctt 480 gcttgctttt taatattgat atgcttatac acttacactt tatgcacaaa atgtagggtt 540 ataataatgt taacatggac atgatcttct ttataattct actttgagtg ctgtctccat 600 gtttgatgta tctgagcagg ttgctccaca ggtagctcta ggagggctgg caacttagag 660 gtggggagca gagaattctc ttatccaaca tcaacatctt ggtcagattt gaactcttca 720 atctcttgca ctcaaagctt gttaagatag ttaagcgtgc ataagttaac ttccaattta 780 catactctgc ttagaatttg ggggaaaatt tagaaatata attgacagga ttattggaaa 840 tttgttataa tgaatgaaac attttgtcat ataagattca tatttacttc ttatacattt 900 gataaagtaa ggcatggttg tggttaatct ggtttatttt tgttccacaa gttaaataaa 960 tcataaaact tgatgtgtta tctctta 987

Claims

적어도 1종의 티로신 키나제 저해제, 비만세포 저해제 또는 c-Kit 저해제를 인간 환자에게 투여하는 것을 포함하는, 인간 환자에 있어서 암의 치료방법.
제1항에 있어서, 상기 티로신 키나제 저해제, 비만세포 저해제 또는 c-Kit 저해제는 적어도 1종의 항종양제와 조합 투여되는 것인 방법.
제2항에 있어서, 상기 항종양제는 알킬화제, 항유사분열제, 항대사산물제, I형 항토포이소머라제 약물, 백금유사체, 항생제, 호르몬제, 항혈관형성제, 유전자독성제, 세포독성제, 생물제제, 또는 부가적인 티로신 키나제 저해제로부터 선택되며; 특히: 아바렐릭스, 아비라테론 아세테이트, 알데스류킨, 알트레타민, 아나스트로졸, 삼산화비소, 아스파라기나제, 악시티닙, 아자시티딘, 벤다무스틴 염산염, 베바시주맙, 벡사로텐, 비칼루타미드, 레오마이신, 보르테조밉, 브렌툭시맙 베도틴, 부술판, 카바지탁셀, 캄파트, 캄토사르, 카페시타빈, 카르보플라틴, 카르필조밉, 카르무스틴, 세툭시맙, 클로람부실, 시스플라틴, 클라드리빈(2CDA), 클로파라빈, 크리조티닙, 시클로포스파미드, 시타라빈(ARA-C), 시토신 아라비노사이드, 다카르바진, 닥티오마이신, 다사티닙, 다우노루비신, 데시티빈, 데가렐릭스, 데니류킨, 도세탁셀, 독소루비신, 에피루비신, 에리불린 메실레이트, 엘로티닙, 에스트라무스틴 포스페이트, 에토포시드, 에베롤리무스, 엑세메스탄, 플룩스우리딘, 플루다라빈, 플루오로-5-우라실(5 플루오로우라실), 플루오로우리딘-데속시리보스, 플루타미드, 풀베스트란트, 게피티닙, 겜시타빈, 겜투주맙 오조가미신, 히드록시우레아, 이브리투모맙 티욱세탄, 이다루비신, 이포스파미드, 이마티닙, 이필리무맙, 이리노테칸,익사베필론, 라파티닙, 레트로졸, 류코보린, 류프롤리드 아세테이트, 로무스틴, 메클로레타민, 메게스트롤, 멜팔란, 메르캅토퓨린, 메토트렉세이트, 미토마이신, 미토탄, 미토잔트론, 텔라라빈, 닐로티닙,, 닐루타미드, 놀바덱스, 오파투무맙, 옥살리플라틴, 파클리탁셀, 파니투무맙, 파조파닙, 페가스파라가제, peg인터페론, α-2b, 페메트렉세드, 펜토스타틴, 퍼투주맙, 플레릭사포, 프랄라트렉세이트, 프로카르바진, 프로류킨, 로미뎁신, 사파시타빈, 시풀레우셀-T, 소라페닙, 스트렙토조신, 수니티닙, 타목시펜, 테모졸로미드, 템시롤리무스, 테니포시드, 테스토락톤, 데자시타빈, 티오구아닌, 티오테파, 토포테칸, 토르미펜 시트레이트, 트라스투주맙, 트립토렐린, 트록사시타빈, 발루비신, 발스타르, 반데타닙, 베무라페닙, 빈블라스틴, 빈크리스틴 술페이트, 비노렐빈, 비스모데깁, 보리노스타트, 젤로다, 지브-아플리베르셉트, 졸레드론산, FOLFOX (옥살리플라틴 + 5 플루오로우라실 + 폴린산), FOLFIRI (이리노테칸 + 5 플루오로우라실 + 폴린산), 폴피리녹스 (옥살리플라틴 + 이리노테칸 + 5 플루오로우라실 + 폴린산), 및 이들 항종양제들의 조합으로부터 선택되는 것인 방법.
제1항 내지 제3항 중 하나 이상의 항에 있어서, 상기 환자는: 급성 림프구 백혈병 (ALL), 급성 골수성 백혈병 (AML), 부신피질암종, 항문암, B세포 림프종, 기저세포암종, 담관암, 방광암, 골암, 뇌간교종, 뇌종양, 유방암, 자궁경부암, 만성 림프구 백혈병 (CLL), 만성 골수성 백혈병 (CML), 대장암 (CRC), 자궁내막암, 식도암, 안암, 담낭암, 위암, 위장관기질종양 (GIST), 다형교모세포종 (GBM), 털세포 백혈병, 두경부암, 심장암, 간세포(간)암종 (HCC), 호지킨 림프종 및 비-호지킨 림프종s, 카포시 육종, 후두암, 비만세포증, 흑색종, 골수섬유증, 골수형성이상 증후군 (MDS), 다발골수종, 비소세포폐암종 (NSCLC), 폐암(소세포), 흑색종, 코인두암종, 신경내분비종, 신경모세포종, 구강암, 임인두암, 난소암, 췌장암, 부비동 및 비강암, 부갑상선암, 음경암, 인두암, 뇌하수체 선종, 전립선암, 직장암, 신장세포(신장)암종 (RCC), 침샘암, 피부암 (비흑색종), 소장암, 소림프구림프종 (SSL), 연조직 육종, 편평세포암종, T 세포 림프종, 고환암, 구협암, 갑상선암, 삼중음성 유방암, 요도암, 및 자궁암으로부터 선택된 적어도 1종의 암의 치료를 필요로 하는 환자인 것인 방법.
제1항 내지 제4항 중 하나 이상의 항에 있어서, 상기 티로신 키나제 저해제 또는 비만세포 저해제는 티로신 키나제인: c-Kit, PDGFR, Lyn, Fyn 및 DDR1로부터 선택된 키나제 활성의 저해제인 것인 방법.
제5항에 있어서, 상기티로신 키나제 저해제, 비만세포 저해제 또는 c-Kit 저해제는 마시티닙 또는 약학적으로 허용가능한 그의 염인 것인 방법.
제6항에 있어서, 마시티닙의 약학적으로 허용가능한 염은 메실레이트 염인 것인 방법.
제1항 내지 제7항 중 하나 이상의 항에 있어서, 상기 환자는 질병 관련 통증 강도의 예측변수 인자에 기초해서 치료되도록 초기에 선택된 것인 방법.
제8항에 있어서, 상기 환자는 통증에 관련되거나 또는 질병 관련 통증의 치료를 위해 아편유사 진통제를 필요로 하는 암에 걸린 환자인 것인 방법.
제9항에 있어서, 상기 통증은 통증 강도 평가 툴을 이용하여 탐지 시, 0이 아닌(non-zero) 통증 강도가 적어도 한 번 일어난 것으로 보고된 것으로 정의되는 것인 방법.
제9항에 있어서, 상기 질병 관련 통증은 20%를 초과하는 일차원 통증 강도 평가 툴 점수가 적어도 한 번 일어난 것으로 보고된 것으로 정의되는 것인 방법.
제9항에 있어서, 상기 환자는 사용된 통증 평가 툴에 따라 보통 내지 참을 수 없는 암 관련 통증 강도를 갖는 것으로 진단되는 것인 방법.
제8항에 있어서, 상기 환자는 통증과 관련된 암 또는 질병 관련 통증의 치료를 위해 아편유사 진통제의 투여를 필요로 하는 암에 걸려 있고, 상기 질병 관련 통증은 100 mm 스케일 상에서 5 mm를 초과하는 시각상사척도 (VAS) 통증 강도 점수가 적어도 한 번 일어난 것으로 보고된 것으로 정의된 것인 방법.
제8항에 있어서, 상기 환자는 통증과 관련된 췌장암 또는 질병 관련 통증의 치료를 위해 아편유사 진통제의 투여를 필요로 하는 췌장암에 걸려 있고, 상기 질병 관련 통증은 100 mm 스케일 상에서 20 mm를 초과하는 시각상사척도 (VAS) 통증 강도 점수가 적어도 한 번 일어난 것으로 보고된 것으로 정의된 것인 방법.
제1항 내지 제7항 중 하나 이상의 항에 있어서, 상기 환자는 유전자 발현의 예측변수 인자에 기초하여 치료에 처음 선택되는 것인 방법.
제15항에 있어서, 상기 유전자 발현 예측변수 인자는 말초혈액세포 샘플에서 RNA 발현 분석으로부터 유도되는 것인 방법.
제15항 내지 제16항 중 하나 이상의 항에 있어서, 상기 환자는 ACOX-1의 상향조절에 기초하여 처음 치료에 선택되며, 좋기로는 델타 사이클 역치 값이 3.81 이하; 더욱 좋기로는 3.36 이하; 및 더더욱 좋기로는 3.05 이하에 대응하는 것인 방법.
제15항 내지 제16항 중 하나 이상의 항에 있어서, 상기 환자는 좋기로는 3.05 이하의 델타 사이클 역치값에 대응하는 유전자 ACOX-1의 상향조절과 좋기로는 6.1 이하의 델타 사이클 역치값에 대응하는 TNFRSF10B의 상향조절을 동시에 갖는 것으로 정의되는 유전자 발현 예측인자 변수에 기초하여 처음 치료에 선택되는 것인 방법.
제15항 내지 제16항 중 하나 이상의 항에 있어서, 상기 환자는 좋기로는 0.35 이하의 델타 사이클 역치값에 대응하는 유전자 RPS23의 상향조절과 좋기로는 3.05 이하의 델타 사이클 역치값에 대응하는 유전자 ACOX-1의 상향조절을 동시에 갖는 것으로 정의되는 유전자 발현 예측인자 변수에 기초하여 처음 치료에 선택되는 것인 방법.
제15항 내지 제16항 중 하나 이상의 항에 있어서, 상기 환자는 좋기로는 4.3 이하의 델타 사이클 역치값에 대응하는 유전자 ABCC3의 상향조절과 좋기로는 1.65 이하의 델타 사이클 역치값에 대응하는 유전자에 대응하는 유전자 LYN의 상향조절을 동시에 갖는 것으로 정의되는 유전자 발현 예측인자 변수에 기초하여 처음 치료에 선택되는 것인 방법.
제15항 내지 제16항 중 하나 이상의 항에 있어서, 상기 환자는 좋기로는 3.95 이하의 델타 사이클 역치값에 대응하는 유전자 HIF1A의 상향조절과, 좋기로는 5.65 이하의 델타 사이클 역치값에 대응하는 유전자 TNFRSF10의 상향조절을 동시에 갖는 것으로 정의되는 유전자 발현 예측인자 변수에 기초하여 처음 치료에 선택되는 것인 방법.
제15항 내지 제16항 중 하나 이상의 항에 있어서, 상기 환자는 좋기로는 3.5를 초과하는 델타 사이클 역치값에 대응하는 유전자 ABCC1의 하향조절과 7.05를 초과하는 델타 사이클 역치값에 대응하는 유전자 IGJ의 하향조절을 동시에 갖는 것으로 정의되는 유전자 발현 예측인자 변수에 기초하여 처음 치료에 선택되는 것인 방법.
제15항 내지 제16항 중 하나 이상의 항에 있어서, 상기 환자는 좋기로는 3.7을 초과하는 델타 사이클 역치값에 대응하는 유전자 UBE2H의 상향조절과, 좋기로는 7.1을 초과하는 델타 사이클 역치값에 대응하는 유전자 PARP-2의 하향조절을 동시에 갖는 것으로 정의되는 유전자 발현 예측인자 변수에 기초하여 처음 치료에 선택되는 것인 방법.
제15항 내지 제16항 중 하나 이상의 항에 있어서, 상기 환자는 3.36 이하의 델타 사이클 역치값에 대응하는 유전자 ACOX-1의 상향조절과, 6.71 이하의 델타 사이클 역치값에 대응하는 유전자 TNFRSF10B의 상향조절을 동시에 갖는 것으로 정의되는 유전자 발현 예측인자 변수에 기초하여 처음 치료에 선택되는 것인 방법.
제15항 내지 제16항 중 하나 이상의 항에 있어서, 상기 환자는 0.32를 초과하는 델타 사이클 역치값에 대응하는 유전자 RPS23의 하향조절과, 3.36 이하의 델타 사이클 역치값에 대응하는 유전자 ACOX-1의 상향조절을 동시에 갖는 것으로 정의되는 유전자 발현 예측인자 변수에 기초하여 처음 치료에 선택되는 것인 방법.
제15항 내지 제16항 중 하나 이상의 항에 있어서, 상기 환자는 4.73 이하의 델타 사이클 역치값에 대응하는 유전자 ABCC3의 상향조절과, 1.82 이하의 델타 사이클 역치값에 대응하는 유전자 LYN의 상향조절을 동시에 갖는 것으로 정의되는 유전자 발현 예측인자 변수에 기초하여 처음 치료에 선택되는 것인 방법.
제15항 내지 제16항 중 하나 이상의 항에 있어서, 상기 환자는 4.35 이하의 델타 사이클 역치값에 대응하는 유전자 HIF1A의 상향조절과, 6.22 이하의 델타 사이클 역치값에 대응하는 유전자 TNFRSF10의 상향조절을 동시에 갖는 것으로 정의되는 유전자 발현 예측인자 변수에 기초하여 처음 치료에 선택되는 것인 방법.
제15항 내지 제16항 중 하나 이상의 항에 있어서, 상기 환자는 3.15를 초과하는 델타 사이클 역치값에 대응하는 유전자 ABCC1의 하향조절과, 6.35를 초과하는 델타 사이클 역치값에 대응하는 유전자 IGJ의 하향조절을 동시에 갖는 것으로 정의되는 유전자 발현 예측인자 변수에 기초하여 처음 치료에 선택되는 것인 방법.
제15항 내지 제16항 중 하나 이상의 항에 있어서, 상기 환자는 3.33을 초과하는 델타 사이클 역치값에 대응하는 유전자 UBE2H의 상향조절과, 6.39를 초과하는 델타 사이클 역치값에 대응하는 유전자 PARP-2의 하향조절을 동시에 갖는 것으로 정의되는 유전자 발현 예측인자 변수에 기초하여 처음 치료에 선택되는 것인 방법.
제15항 내지 제16항 중 하나 이상의 항에 있어서, 상기 환자는 3.81 이하의 델타 사이클 역치값에 대응하는 유전자 ACOX-1의 상향조절과, 7.63 이하의 델타 사이클 역치값에 대응하는 유전자 TNFRSF10B의 상향조절을 동시에 갖는 것으로 정의되는 유전자 발현 예측인자 변수에 기초하여 처음 치료에 선택되는 것인 방법.
제15항 내지 제16항 중 하나 이상의 항에 있어서, 상기 환자는 0.26을 초과하는 델타 사이클 역치값에 대응하는 유전자 RPS23의 하향조절과, 3.81 이하의 델타 사이클 역치값에 대응하는 유전자 ACOX-1의 상향조절을 동시에 갖는 것으로 정의되는 유전자 발현 예측인자 변수에 기초하여 처음 치료에 선택되는 것인 방법.
제15항 내지 제16항 중 하나 이상의 항에 있어서, 상기 환자는 5.38 이하의 델타 사이클 역치값에 대응하는 유전자 ABCC3의 상향조절과, 2.06 이하의 델타 사이클 역치값에 대응하는 유전자 LYN의 상향조절을 동시에 갖는 것으로 정의되는 유전자 발현 예측인자 변수에 기초하여 처음 치료에 선택되는 것인 방법.
제15항 내지 제16항 중 하나 이상의 항에 있어서, 상기 환자는 4.94 이하의 델타 사이클 역치값에 대응하는 유전자 HIF1A의 상향조절과, 7.06 이하의 델타 사이클 역치값에 대응하는 유전자 TNFRSF10의 상향조절을 동시에 갖는 것으로 정의되는 유전자 발현 예측인자 변수에 기초하여 처음 치료에 선택되는 것인 방법.
제15항 내지 제16항 중 하나 이상의 항에 있어서, 상기 환자는 2.63을 초과하는 델타 사이클 역치값에 대응하는 유전자 ABCC1의 하향조절과, 5.29를 초과하는 델타 사이클 역치값에 대응하는 유전자 IGJ의 하향조절을 동시에 갖는 것으로 정의되는 유전자 발현 예측인자 변수에 기초하여 처음 치료에 선택되는 것인 방법.
제15항 내지 제16항 중 하나 이상의 항에 있어서, 상기 환자는 2.78을 초과하는 델타 사이클 역치값에 대응하는 유전자 UBE2H의 상향조절과, 5.33을 초과하는 델타 사이클 역치값에 대응하는 유전자 PARP-2의 하향조절을 동시에 갖는 것으로 정의되는 유전자 발현 예측인자 변수에 기초하여 처음 치료에 선택되는 것인 방법.
제6항 내지 제16항 중 하나 이상의 항에 있어서, 마시티닙은 4.5 내지 12.0 mg/kg/일 (1일 체중 1 kg 당 mg)의 1일 투여량으로 투여되는 것인 방법.
제36항에 있어서, 마시티닙은 6.0 내지 7.5 mg/kg/일의 출발 투여량으로 투여되는 것인 방법.
제36항 내지 제37항 중 하나 이상의 항에 있어서, 마시티닙은 최대 12.0 mg/kg/일에 도달할 때까지 1.5 mg/kg/일씩 증분되어 투여되는 것인 방법.
선행하는 항들 중 하나 이상의 항에 있어서, 상기 티로신 키나제 저해제, 비만세포 저해제 또는 c-Kit 저해제는 경구 투여되는 것인 방법.
선행하는 항들 중 하나 이상의 항에 있어서, 상기 티로신 키나제 저해제, 비만세포 저해제 또는 c-Kit 저해제는 1일 2회 투여되는 것인 방법.
선행하는 항들 중 하나 이상의 항에 있어서, 티로신 키나제 저해제, 비만세포 저해제 또는 c-Kit 저해제의 유효량은 3 개월을 초과하는 장기간 동안 투여되는 것인 방법.
제2항 내지 제41항 중 하나 이상의 항에 있어서, 상기 환자는 상기 적어도 1종의 항종양제에 대해 나이브하거나 상기 적어도 1종의 항종양제를 이용하는 치료에 대해 반응성인 환자인 것인 방법.
제2항 내지 제41항 중 하나 이상의 항에 있어서, 상기 환자는 상기 적어도 1종의 항종양제에 대해 무반응성이거나 내성을 나타내는 환자인 것인 방법.
제2항 내지 제43항 중 하나 이상의 항에 있어서, 상기 티로신 키나제 저해제, 비만세포 저해제 또는 c-Kit 저해제는 네오아쥬반트, 아주반트, 부수요법 또는 동시요법으로서 적어도 1종의 항종양제와 조합 투여되는 것인 방법.
제2항 내지 제44항 중 하나 이상의 항에 있어서, 상기 티로신 키나제 저해제, 비만세포 저해제 또는 c-Kit 저해제는 상기 적어도 1종의 항종양제와 동시, 별도 또는 순차적인 사용을 위하여 조합 투여되는 것인 방법.
선행하는 항들 중 하나 이상의 항에 있어서,
제2항 내지 제44항 중 하나 이상의 항에 있어서, 상기 티로신 키나제 저해제, 비만세포 저해제 또는 c-Kit 저해제는 제3항에 기재된 적어도 1종의 항종양제와 조합 투여되는 것인 췌장암의 치료 방법.
선행하는 항들 중 하나 이상의 항에 있어서, 상기 환자는 절제불가능한 선암종 췌장암을 앓는 환자인 것인 방법.
제1항 내지 제46항 중 하나 이상의 항에 있어서, 상기 환자는 전이성 선암종 췌장암을 앓는 환자인 것인 방법.
제46항 내지 제48항 중 하나 이상의 항에 있어서, 상기 췌장암 환자는 제8항 내지 제14항 또는 제15항 내지 제35항에서 정의된 바와 같고, 상기 적어도 1종의 항종양제는: 겜시타빈 (Gemzar
; Lilly), 엘로티닙 (Tarceva
Roche), 파클리탁셀 (Taxol
, Abraxane
, Bristol-Myers Squibb), 폴피리녹스, 5-플루오로우라실 (5-FU), 카페시타빈, 시스팔라틴, 옥살리플라틴, 이리노테칸, 류코보린, 및 이들 항종양제들의 조합으로부터 선택되는 것인 방법.
제45항에 있어서, 상기 적어도 1종의 항종양제는 겜시타빈인 것인 방법.
제46항에 있어서, 겜시타빈은 항종양제로서 사용되고 마시티닙 또는 약학적으로 허용되는 그의 염 또는 수화물은 티로신 키나제 저해제, 비만세포 저해제 또는 c-Kit 저해제로서 사용되는 것인 방법.
제46항에 있어서, 마시티닙은 출발 투여량을 6.0 ± 1.5 mg/kg/일로 하되 최대 허용가능한 투여량을 9.0 mg/kg/일로 하여 투여되고, 겜시타빈은 1주일 투여량을 1000 ± 250 mg/m²의 환자 체표면적으로 하여 처음 최대 7주일 동안 연속 투여한 다음 1주일간 투여를 중단하고 이어서 28일마다, 3주일 동안 1주일에 1000 ±250 mg/m²의 투여량으로 투여되는 것인 방법.
제1항 내지 제52항 중 어느 하나의 항에서 정의된 암의 치료방법에 사용되기 위한 티로신 키나제 저해제, 비만세포 저해제 또는 c-Kit 저해제.
제53항에 있어서, 적어도 1종의 항종양제와 조합되는 티로신 키나제 저해제, 비만세포 저해제 또는 c-Kit 저해제.
제1항 내지 제52항 중 어느 하나의 항에서 정의된 암의 치료방법에 사용되기 위한, 티로신 키나제 저해제, 비만세포 저해제 또는 c-Kit 저해제를 포함하는 의약 조성물 또는 키트.
제55항에 있어서, 적어도 1종의 항종양제를 포함하는 의약 조성물 또는 키트.
제1항 내지 제54항 중 어느 하나의 항에서 정의된 암의 치료를 위한 의약 또는 의약 조성물의 제조를 위한 티로신 키나제 저해제, 비만세포 저해제 또는 c-Kit 저해제의 용도.
제57항에 있어서, 상기 티로신 키나제 저해제, 비만세포 저해제 또는 c-Kit 저해제는 적어도 1종의 항종양제와 조합 사용되는 것인 용도.
유전자 발현의 예측변수 인자에 기초하여 치료가능한 환자들을 동정하기 위한, 인간 환자에 있어서, 암, 특히 췌장암의 치료를 위한 치료 관리 플랜으로서, 상기 관리 플랜은 상기 환자가 제17항 내지 제35항에서 정의된 적어도 하나의 유전자 발현 예측변수 인자들과 관련된 암에 걸렸는지를 탐지하는 것을 포함하는 것인 치료 관리 플랜.
제59항에 있어서, 상기 플랜은 췌장암 환자에게 적용되며:
- 환자가 적어도 1종의 유전자 발현 예측변수 인자를 나타내면 그 환자를 임의로 적어도 1종의 뉴클레오사이드 유사체, 특히 시티딘 유사체, 특히 겜시타빈과 임의로 조합하여 적어도 1종의 티로신 키나제 저해제, 비만세포 저해제 또는 c-Kit 저해제, 특히 마시티닙으로 치료하고;
- 환자가 적어도 1종의 유전자 발현 예측변수 인자를 나타내지 않으면 그 환자를 적어도 1종의 뉴클레오사이드 유사체, 특히 시티딘 유사체, 특히 겜시타빈으로 치료하는 것인,
치료 관리 플랜.
제59항에 있어서, 상기 플랜은 암 환자에게 적용되며:
- 환자가 적어도 1종의 유전자 발현 예측변수 인자를 나타내면 그 환자를 임의로 적어도 1종의 항종양제와 조합하여, 적어도 1종의 티로신 키나제 저해제, 비만세포 저해제 또는 c-Kit 저해제, 특히 마시티닙으로 치료하고:
- 환자가 적어도 1종의 유전자 발현 예측변수 인자를 나타내지 않으면 그 환자를 적어도 1종의 항종양제로 치료하는 것인,
치료 관리 플랜.
통증 강도의 예측변수 인자에 기초하여 치료가능한 환자들을 동정하기 위한, 인간 환자에 있어서, 암, 특히 췌장암의 치료를 위한 치료 관리 플랜으로서, 상기 관리 플랜은:
a) 상기 환자가 통증과 연관되거나 또는 질병 관련 통증의 치료를 위해 적어도 1종의 아편유사 진통제의 투여를 필요로 하는 암에 걸려있는지를 탐지하는 단계로서, 여기서 상기 통증의 강도는 좋기로는 100 mm 스케일 상에서 5 mm를 초과하는시각상사척도 (VAS) 점수가 일어난 것으로 정의되는 것인 단계; 및
임의로
b) 상기 질병 관련 통증이 100 mm 스케일 상에서 상기 암에 대해 사전정의된 값보다 더 높은 시각상사척도 (VAS) 통증 강도 점수가 일어난 것인지, 특히 췌장암에 있어서, 100 mm 스케일 상에서 시각상사척도 (VAS) 통증 강도 점수가 20 mm를 초과하는지를 탐지하는 단계
를 포함하는 것인 치료 관리 플랜.
제62항에 있어서, 상기 플랜은 췌장암 환자에게 적용되며:
- 단계 (a)의 결과가 부정적이면, 환자를 적어도 1종의 뉴클레오사이드 유사체, 특히 시티딘 유사체, 특히 겜시타빈으로 치료하고:
- 단계 (a)의 결과가 긍정적이고 단계 (b)의 결과가 부정적이면, 적어도 1종의 약물 표적 표피성장인자 수용체 (EGFR), 특히 엘로티닙을 적어도 1종의 뉴클레오사이드 유사체, 특히 시티딘 유사체, 특히 겜시타빈과 조합한 것; 또는 적어도 1종의 유사분열 저해제, 특히 파클리탁셀을 적어도 1종의 뉴클레오사이드 유사체, 특히 시티딘 유사체, 특히 겜시타빈과 조합한 것; 또는 플루오로우라실, 류코보린, 이리노테칸, 또는 옥살리플라틴, 특히 폴피리녹스를 포함하는 약물들의 적어도 1종의 조합으로 환자를 치료하며
- 단계 (a)의 결과가 긍정적이고 단계 (b)의 결과도 긍정적이면, 적어도 1종의 티로신 키나제 저해제, 비만세포 저해제 또는 c-Kit 저해제, 특히 마시티닙을, 임의로 적어도 1종의 뉴클레오사이드 유사체, 특히 시티딘 유사체, 특히 겜시타빈과 조합하여 환자를 치료하는 것인 치료 관리 플랜.
제62항에 있어서, 상기 플랜은 췌장암이 아닌 암 환자에게 적용되며:
- 단계 (a)의 결과가 부정적이면, 환자를 적어도 1종의 항종양제로 치료하고:
- 단계 (a)의 결과가 긍정적이고 단계 (b)의 결과가 부정적이면, 환자를 적어도 1종의 항종양제로 치료하며
- 단계 (a)의 결과가 긍정적이고 단계 (b)의 결과도 긍정적이면, 적어도 1종의 티로신 키나제저해제, 비만세포 저해제 또는 c-Kit 저해제, 특히 마시티닙을 임의로 적어도 1종의 항종양제와 조합하여 환자를 치료하는 것인 치료 관리 플랜.
제59항에 정의된 유전자 발현 치료 관리 플랜 및 제65항에 정의된 통증 강도 치료 관리 플랜의 순차 적용에 기초하여 치료가능한 환자들을 동정하기 위한, 인간 환자에 있어서, 암, 특히 췌장암의 치료를 위한 치료 관리 플랜으로서, 상기 통증 강도 치료 관리 플랜의 단계 (a)에 앞서서, 환자가 제17항 내지 제35항에 정의된 바와 같은 적어도 1개의 유전자 발현 예측변수 인자와 연관된 암에 걸렸는지를 탐지하는 것으로 이루어진 단계 (a)를 먼저 실시하는 것인 전체 치료 관리 플랜.
제65항에 있어서, 상기 플랜은 췌장암 환자에게 적용되며:
- 단계 (a')의 결과가 긍정적이면, 티로신 키나제 저해제, 비만세포 저해제 또는 c-Kit 저해제, 특히 마시티닙을 임의로 적어도 1종의 뉴클레오타이드 유사체, 특히 시티딘 유사체, 특히 겜시타빈과 조합하여 환자를 치료하고;
- 단계 (a')의 결과가 부정적이면, 췌장암에 대한 통증 강도 치료 관리 플랜의 단계 (a)를 적용하되( 제62항 및 제63항에 정의된 바와 같음), 특히, 상기 관리 플랜은:
a) 상기 환자가 통증과 연관된 췌장암에 걸렸는지 또는 통증, 좋기로 는 100 mm 스케일에서 5 mm를 초과하는 시각상사척도(VAS) 점수를 나 타내는 것으로 보고된 것으로 정의된 질병 관련 통증의 치료를 위해 적어도 1종의 아편유사 진통제의 투여를 필요로 하는지를 결정하는 단 계; 및 임의로
b) 상기 질병 관련 통증이 100 mm 스케일에서 20 mm를 초과하는 시각 상사척도 (VAS) 통증 강도 점수를 나타내는지를 결정하는 단계
를 포함하는 것임.
- 단계 (a)의 결과가 부정적이면, 환자를 적어도 1종의 뉴클레오사이드 유사체, 특히 시티딘 유사체, 특히 겜시타빈으로 치료하고,
- 단계 (a)의 결과가 긍정적이고, 단계 (b)의 결과는 부정적이면, 적어도 1종의 약물 표적 표피성장인자 수용체 (EGFR), 특히 엘로티닙을 적어도 1종의 뉴클레오사이드 유사체, 특히 시티딘 유사체, 특히 겜시타빈과 조합한 것; 또는 적어도 1종의 유사분열 저해제, 특히 파클리탁셀을 적어도 1종의 뉴클레오사이드 유사체, 특히 시티딘 유사체, 특히 겜시타빈과 조합한 것; 플루오로우라실, 류코보린, 이리노테칸, 또는 옥살리플라틴, 특히 폴피리녹스를 포함하는 약물들의 적어도 1 가지 조합으로 환자를 치료하며,
- 단계 (a)의 결과가 긍적적이고, 단계 (b)의 결과도 긍정적이면, 적어도 1종의 티로신 키나제 저해제, 비만세포 저해제 또는 c-Kit 저해제, 특히 마시티닙을, 임의로 적어도 1종의 뉴클레오사이드 유사체, 특히 시티딘 유사체, 특히 겜시타빈과 조합하여 환자를 치료하는 것인, 치료 관리 플랜.
제65항에 있어서, 상기 플랜은 췌장암이 아닌 암 환자에게 적용되며:
- 단계 (a')의 결과가 긍정적이면, 적어도 1종의 티로신 키나제 저해제, 비만세포 저해제 또는 c-Kit 저해제, 특히 마시티닙을 임의로 적어도 1종의 뉴클레오타이드 유사체, 특히 시티딘 유사체, 특히 겜시타빈과 조합하여 환자를 치료하고;
- 단계 (a')의 결과가 부정적이면, 암에 대한 통증 강도 치료 관리 플랜의 단계 (a)를 적용하되 (제62항 및 제64항에 정의된 바와 같음), 상기 관리 플랜은:
a) 상기 환자가 통증과 연관된 암에 걸렸는지 또는 100 mm 스케일에서 5 mm를 초과하는 시각상사척도(VAS) 점수를 나타내는 것으로 보고된 것으로 정의된 질병 관련 통증의 치료를 위해 적어도 1종의 아편유사 진통제의 투여를 필요로 하는지를 결정하는 단계; 및 임의로
b) 상기 질병 관련 통증이 100 mm 스케일에서 20 mm를 초과하는 시각 상사척도 (VAS) 통증 강도 점수를 나타내는 지를 결정하는 단계
를 포함하는 것이고;
- 단계 (a)의 결과가 부정적이면, 환자를 적어도 1종의 항종양제로 치료하며,
- 단계 (a)의 결과가 긍정적이고, 단계 (b)의 결과는 부정적이면, 환자를 적어도 1종의 항종양제로 치료하고,
- 단계 (a)의 결과가 긍정적이고 단계 (b)의 결과도 긍정적이면, 적어도 1종의 티로신 키나제 저해제, 비만세포 저해제 또는 c-Kit 저해제, 특히 마시티닙을 임의로 적어도 1종의 항종양제와 조합하여 환자를 치료하는 것인 치료 관리 플랜.