KR20050046049A - Improved delivery systems for oral care substances to tooth - Google Patents

Abstract

The present invention relates to a tooth sticking formulation with improved performance, comprising a drug layer, a support layer, and an intermediate layer located between the drug layer and the support layer, Due to the intermediate layer positioned between the supporting layers to increase the bonding force between the layers, not only can the interlayer peeling phenomenon be suppressed, but also the additives can be contained without inhibiting the stability over time, thereby improving the whitening effect and the stability over time. Can be.

Description

IMPROVED DELIVERY SYSTEMS FOR ORAL CARE SUBSTANCES TO TOOTH}

The present invention relates to an adhesive preparation with improved performance, including an intermediate layer between the drug layer and the support layer, to deliver the drug substance to the tooth by attachment to the tooth, as well as to the physical properties and contained components of the intermediate layer itself. It is related to tooth-bearing preparations characterized by improving the performance of the product.

The most representative formulation for delivering drugs to the prior art is known as toothpaste. However, toothpaste has a problem in that the drug can not effectively deliver the medicinal substance to the tooth because the contact time between the tooth and the drug is short as 1 to 3 minutes.

In order to solve the drawbacks of the toothpaste formulation, Lion (Lion) proposes a sheet-type oral patch (Plasters) in Japanese Patent Application Laid-Open No. 10-17448. The oral patch disclosed herein is composed of a drug layer (tooth attachment layer) and a support layer, and the whitening agent is kojic acid and its derivatives, ascorbic acid, ascorbic acid derivatives, peroxide component (carbamide peroxide), but among them, kojic acid and various salts thereof are described as effective. However, this oral patch is concerned about the occurrence of irritation according to pH in the oral cavity because all of the used drug substance (whitening agent) has a strong acidity. In addition, since the whitening effect is exhibited only in strong acidic properties of these whitening agents, there is also a problem that it is difficult to obtain a patch having excellent whitening effect with little irritation. In addition, the oral patch has a two-layer structure, which does not solve the problem of easy peeling of the drug layer and the support layer, and also requires a structural material in which the drug whitening component and the raw material having poor compatibility with the tooth whitening component must be prescribed simultaneously. There is a limit.

Procter & Gamble, on the other hand, uses a tooth whitening agent in a thin, transparent and flexible polyethylene strip instead of using a mouse tray in US Pat. Nos. 5,879,691, 5,891,453 and 5,989,569, and WO 98/55044. We present a tooth whitening delivery system that pre-coates low-professional whitening gels or similar prescriptions or is applied directly to a tooth or strip prior to use and then attached. The system disclosed herein also has a two-layer structure, which improves simplicity in use by not using a mouse tray, and is transparent and thin when worn. As can be seen from the examples, however, this system is a wet type of thin pre-coated thin flexible gel strips with a high viscosity gel using a large amount of carbopol as the main gelling agent. As a wet type, a high concentration of peroxide gel is easily applied to the hands, tongue, gums, etc. at the time of attachment, and there is much room for improvement in terms of usability. In addition, due to the limitation of the present formulation consisting of a two-layer structure of a tooth whitening agent and a strip, it is difficult to expect stabilization of peroxides, so there is a concern that the whitening effect of storage during long-term storage is reduced.

In addition, Colgate has combined an active ingredient with Dow Corning 3179 Dilatant Compound in US Pat. Nos. 5,310,563 and 5,639,445 to form one, then lightly press it onto the tooth for easy removal. Formulations are disclosed. Here, the peroxide is encapsulated in the polymer to prevent contact with the highly reactive peroxide and other components in the drug layer, which may provide some stability over time, but the active ingredient is removed from the delayed compound in a short time. Since it is difficult to come out, there is a disadvantage that a long contact time is required to obtain a whitening effect.

On the other hand, Korean Patent Application No. 10-2003-0001297 of the present applicant discloses a tooth whitening agent of several layers, in which multiple layers are added by adding an adhesive layer to increase adhesion between the tooth and the drug layer. The intermediate layer having a new function is not interposed between the drug layer and the support layer as in the present invention.

Conventional tooth whitening agent consists of a release agent, a drug layer and a support layer, the release agent to help the peeling by surface treatment such as silicone, if necessary, the drug layer is hydrated by moisture using a hydrophilic polymer to exert the adhesive force, at the same time Releases whitening material. Since the support layer serves to prevent the shape of the product from being disturbed by saliva or the like, it is appropriate that the support layer is water-insoluble or partially water-soluble. That is, in the conventional preparation for tooth whitening, since the drug layer is water-soluble and the support layer is water-insoluble, there is a problem that compatibility with each other is poor.

In the present invention, to solve the problems of the conventional tooth whitening agent, to improve the compatibility between the drug layer and the support layer to increase the binding force between them, while containing additives without inhibition of aging stability and improved its function To provide a tooth-adhesive whitening agent.

To achieve the above object, in the present invention, the tooth-attachable whitening preparation for attaching to the tooth and delivering the drug includes a drug layer, a support layer, and an intermediate layer positioned between the drug layer and the support layer. Provide a whitening agent.

Here, the intermediate layer may consist of a single layer or two or more layers, and may include a peroxide activator, a pigment substance, TiO ₂ , HAP (hydroxyapatite), a perfume, a bad breath inhibitor, a perceptual hypersensitivity agent, a fluorine, a gum disease agent, or these It may include a mixture of.

A feature of the present invention is to devise an intermediate layer in order to solve the problem of poor compatibility between the water-soluble drug layer and the water-insoluble support layer in the tooth-adhesive preparation including the drug layer and the support layer. The intermediate layer is located between the drug layer and the support layer to play a role of enhancing the binding force between the drug layer and the support layer, and has the function of containing an additive without impairing the stability over time of highly reactive medicinal components such as hydrogen peroxide.

1 is a schematic cross-sectional view showing a tooth attachment preparation having a three-layer structure according to the present invention. As shown here, the tooth-bearing preparation of the present invention is characterized by being composed of a release agent (1), a drug layer (2), an intermediate layer (3) and a support layer (4). Hereinafter, the configuration of the tooth attachment preparation according to the present invention will be described in detail.

First, the release agent is a formulation having a certain level of rigidity, such as PET, PE, paper, etc., which helps to peel off the tooth attachment by coating on one or both sides of the release agent as necessary.

The dry layer is preferably a dry type in which the drug layer has no adhesive strength or weak strength in a dry state, but is released or begins to be hydrated as it is hydrated by a small amount of water in a region where the whitening agent is desired to act. However, it can also be used as a gel (gel) attached to the teeth by its own viscosity. Polymers used herein must be hydrophilic or at least partially hydrophilic. Mainly used polymers include polyalkyl vinyl ether-maleic acid copolymers (PVM / MA copolymer; Gantrez AN 119, AN 139, S-97), polyvinyl alcohol, polyacrylic acid, poloxamer 407 (Poloxamer 407; Pluronic, poly ( ethylene oxide) -poly (propylene oxide) -poly (ethylene oxide) triblock copolymer), polyethylene oxide (Polyox), polyvinylpyrrolidone-vinylacetate copolymer (PVP / VA copolymer; Luviskol VA, Plasdone S PVP / VA) , Polyvinylpyrrolidone (PVP; K-15 to K-120), polyquaternium-11 (polyquaternium-11, Gafquat 755N), polyquaternium-39 (merquat plus 3330), carboxypolymethylene (Carbomer, Carbopol), hydroxypropylmethyl cellulose, hydroxyethyl cellulose, hydroxypropyl cellulose, gelatin, sodium alginate alone or mixtures thereof can be used. As the solvent of these polymers, water, ethanol alone or a mixture thereof, and other organic solvents such as ethyl acetate, methylene chloride, isopropyl alcohol, acetonitrile alone, or a mixture thereof may be used in proportion. .

The tooth attachment must be flexible enough because it attaches directly to the tooth and must be easily shaped as the tooth flexes. Since some of these polymers are inferior in flexibility, a suitable plasticizer may be added. Suitable plasticizers vary depending on the type of polymer and its formulation, but are commonly used polypropylene glycol, glycerin or polyethylene glycol, all of which can be used.

Some of the less compatible with the peroxide in the hydrophilic polymer can be used by adding a peroxide stabilizer. Stabilizers to stabilize peroxides in formulations include alkyl aryl sulfonates, alkyl sulfonate salts, alkyl carboxylate salts, alkyl diphenyloxide disulfonates, Span 20; Sorbitan Monolaurate, Span 40; Sorbitan Monopalmitate), Span 60; Sorbitan Monostearate, Span 80; Sorbitan Monooleate, Span 85, Sorbitan Trioleate, TWEEN; POE sorbitan fatty acid ester, Glycerin fatty acid ester, Organic acid monoglycerides, stearyl sodium lactate, polysorbate (POE (20) Sorbitan Monolaurate, POE (20) Sorbitan Monostearate, POE (20) Sorbitan Monooleate, POE (20) Sorbitan Tristearate, POE (20) Sorbitan Trioleate) . Among these, 1 type or more can be mixed and used.

Examples of the tooth whitening component added to the drug layer include peroxides, polyphosphates, enzymes, and chlorine bleaches. Peroxides include hydrogen peroxide, carbamide peroxide, calcium peroxide, sodium percarbonate, sodium perborate, sodium perorate and tetrasodium pyrophosphate peroxidate and mixtures thereof It can select from the group which consists of these, and can use. Phosphates and enzymes are effective at removing major stains in the enamel adhesion layer. Examples of polyphosphates include sodium pyrophosphate (TSPP), sodium pyrophosphate (SAPP), sodium hexametaphosphate (SHMP), sodium tripolyphosphate (STP), One or two of sodium potassium tripolyphosphate (SKTP), potassium pyrophosphate (TKPP), and ultraphosphate acidic sodium meta-polyphosphate and acidic sodium polyphosphate More than one species can be used. In general, polyphosphate is known to be effective as a tartar control agent in toothpaste to inhibit tartar formation or to remove tartar. In addition, they are good chelating agents of metals, which can effectively remove tooth stains produced by metals such as iron, calcium, and magnesium in food or working environment among tooth stains, which may contribute to the improvement of the whitening effect. The use of these polyphosphates in the formulations of the present invention not only improves the whitening effect by eliminating light extrinsic stains, but also prolongs the contact time between teeth and condensed phosphates, which is effective in inhibiting tartar formation or removing tartar. It is expected to be. Chlorine-based bleaches include sodium chlorite and sodium hypochlorite. In addition, papain, vitamin E and sodium bicarbonate may also be used as a whitening agent.

It is also possible to add a chelating agent such as EDTA, sodium citrate or Dequest phosphonates to the drug layer for the purpose of improving the time stability of the peroxide.

The backing layer in the formulation according to the present invention serves to protect the interior (intermediate layer, drug layer) from physical and chemical contact, such as saliva, oral contact, or helps maintain the shape of the product. In order to perform such a function, it is preferable to use a water-insoluble polymer or a polymer which is partially insoluble in water. Available polymers include cellulose acetate phthalate, shellac, polyvinyl acetate, ethyl cellulose, poly methyl methacrylate, methacryloyl ethyl betaine / methacrylate copolymer (Yukaformer: Mitsubishi, methacryloylethyl betain / methacrylate copolymer, methacrylic acid copolymer (Ecrydranic L copolymer, Eudragit L 100, Eudragit L 12,5, Eudragit L 100-55, Eudragit L 30D-55), aminoalkyl methacrylate copolymer (Eudragit E 100, Eudragit E 12,5, Eudragit RL 100, Eudragit RL 30D) alone or a mixture thereof. In addition, a polymer which does not dissolve in oral conditions as an enteric coating material is preferable. In addition to the casting process using a solvent, a method of making a sheet by an extrusion method using a thermoplastic polymer is also possible.

The backing layer may also be used by adding various plasticizers for the same reasons as the adhesive layer or the drug layer containing the peroxide. In addition to the above-mentioned plasticizers propylene glycol, glycerin and polyethylene glycol, more plasticizers may be used depending on the solvent used, and caster oil and hydrogenated caster oil may also be used.

In the formulation according to the invention the intermediate layer is located between the drug layer and the support layer. The drug layer and the support layer mentioned above are hydrophilic and the support layer is hydrophobic due to the characteristics of the polymer used in each. Therefore, these drug layers and support layers are incompatible with each other and the layers are easy to separate. One of the main purposes of the intermediate layer is to be located between the drug and support layers to inhibit the separation of the two layers, which must be prescribed to be friendly to both layers. As a method, the polymer which is friendly to both layers is used for an intermediate | middle layer, the method of improving the adhesive property by raising the surface viscosity of an intermediate | middle layer, and the method of adjusting interface characteristics using surfactant.

As mentioned above, there is also a method of improving the compatibility between the two layers by adding a surfactant or the like to the drug layer or the support layer, but there is a limitation, which is because the compatibility between the active ingredient and the surfactant is poor and the stability over time such as peroxide Because it falls. In addition, the surfactant is released when it comes in contact with the teeth and skin in the oral cavity, causing irritation in the oral cavity, or the astringency inherent in the surfactant may be a problem. In addition, since the intermediate layer can easily adjust the content of the solvent, such as moisture contained in the present layer, it is possible to easily change the adhesive properties, while in the drug layer or support layer, changing the moisture content, etc. affects the stability and feel of the main components In addition to changing the physical properties of the product, it is not easy to change the moisture content for the purpose of controlling the adhesive properties. For this reason, the drug layer and the support layer are limited in adding a surfactant and the like. However, when the intermediate layer is used as in the present invention, it is possible to minimize or not add a surfactant or a peroxide stabilizer to the drug layer or the support layer.

Another important use of the intermediate layer is that the intermediate layer may contain components that are difficult to add simultaneously due to the highly reactive hydrogen peroxide in the drug layer. General examples of such ingredients include peroxide activators, pigments, TiO ₂ , HAP (hydroxyapatite), fragrances, bad breath inhibitors, perceptual hypersensitivity agents, fluorine, gum disease agents and the like. If the compatibility between these components is poor, it is also possible to administer the intermediate layer in several layers. Figure 2 is a schematic cross-sectional view showing a tooth attachment formulation having a structure of three or more layers according to the present invention, a release agent (1), drug layer (2), intermediate layer (3), intermediate layer-1 (5) and support layer (4) It is also possible to separate and administer the pigment | dye substance to the intermediate | middle layer-1 (5), and fragrance | flavor etc. to the intermediate | middle layer (3).

In addition, the intermediate layer may be positioned between the support layer and the drug layer to serve as a barrier layer. For example, components that inhibit the time stability of the drug layer of the support layer raw material prevents direct contact with the drug layer, thereby improving time stability.

It is possible to use all the polymers used in the drug layer and the support layer in the intermediate layer, provided that these polymers must have excellent compatibility with both the drug layer and the support layer. That is, examples of the polymer that can be used for the intermediate layer include polyalkyl vinyl ether-maleic acid copolymer (PVM / MA copolymer; Gantrez AN 119, AN 139, S-97), polyvinyl alcohol, polyacrylic acid, poloxamer 407 Pluronic, poly (ethylene oxide) -poly (propylene oxide) -poly (ethylene oxide) triblock copolymer), polyethylene oxide (Polyox), polyvinylpyrrolidone-vinylacetate copolymer (PVP / VA copolymer; Luviskol VA, Plasdone S PVP / VA), polyvinylpyrrolidone (PVP; K-15 to K-120), polyquaternium-11 (polyquaternium-11, Gafquat 755N), polyquaternium-39 (polyquaternium-39, Merquat plus 3330 ), Carboxypolymethylene (Carbomer, Carbopol), hydroxypropylmethyl cellulose, hydroxyethyl cellulose, hydroxypropyl cellulose, gelatin, alginate, cellulose acetate phthalate, shellac, polyvinyl acetate , Ethyl cellulose, poly Methyl methacrylate, methacryloyl ethyl betaine / methacrylate copolymer (Yukaformer: manufacturer Mitsubishi, methacryloylethyl betain / methacrylate copolymer), methacrylic acid copolymer (methacrylic acid copolymer; Eudragit L 100, Eudragit L 12, 5, Eudragit L 100-55, Eudragit L 30D-55), aminoalkyl methacrylate copolymer (Eudragit E 100, Eudragit E 12,5, Eudragit RL 100, Eudragit RL 30D) alone or mixtures thereof Can be mentioned.

Hereinafter, the present invention will be described in more detail with preferred embodiments of the present invention. However, these examples are only illustrative to aid the understanding of the present invention, and the scope of the present invention is not limited thereto.

Examples 1-5 and Comparative Examples 1-5

Tooth-attach whitening patches of Examples 1 to 5 and Comparative Examples 1 to 5 were prepared with the composition as described below.

Preparation Method: After applying the drug layer on the release agent, an intermediate layer and / or a support layer was applied thereon.

Example 1

Drug layer preparation solution: Polyvinyl pyrrolidone 22%, hydrogen peroxide 5%, glycerin 10%, ethanol 30%, water was added to make 100%.

Supporting layer preparation solution: 5% polyvinyl acetate, 5% glycerin, and ethanol were added to make 100%.

Intermediate layer preparation solution: 5% of hydroxypropylmethyl cellulose, 1% of sorbitan monooleate and ethanol were added to make 100%.

Example 2

Drug layer preparation solution: 20% of Gantrez S-97, 15% of sodium percarbonate, 3% of propylene glycol, and purified water were added to make 100%.

Support layer preparation solution: 16% ethyl cellulose, 8% castor oil, and ethanol were added to make 100%.

Intermediate layer preparation solution: 2% of carboxymethyl cellulose (Na-CMC), 1% of polyethylene glycol 400, 1% of l-menthol (fragrance), and purified water were added to make 100%.

Example 3

Drug layer preparation solution: 20% polyethylene oxide (polyox), 10% urea peroxide, 50% purified water, ethanol was added to 100%.

Support layer preparation solution: 15% of methacrylic acid copolymer, 20% of purified water, and ethanol were added to make 100%.

Intermediate layer preparation solution: Polyquaternium-39 10%, water was added to 100%.

Example 4

Drug layer preparation solution: 10% of hydroxypropyl cellulose, 20% of hydroxyethyl cellulose, 3% of hydrogen peroxide, 3% of TSPP, 5% of glycerin, and water were added to make 100%.

Support layer preparation solution: 15% of cellulose acetate phthalate, 3% of SAPP, 30% of purified water, and ethanol were added to make 100%.

Intermediate layer preparation solution: Polyvinyl pyrrolidone-vinyl acetate copolymer (PVP / VA copolymer) 20%, sodium fluoride 0.05%, purified water 50%, ethanol was added to 100%.

Example 5

Drug layer preparation solution: 5% polyvinyl alcohol, 6% tetrasodium pyrophosphate peroxidate, an appropriate amount of NaOH (up to pH 7), 5% glycerin, and water were added to make 100%.

Supporting layer preparation solution: Ethyl cellulose 40%, polyethylene glycol 200 10%, ethanol was added to make 100%.

Intermediate layer preparation solution: 10% of hydroxypropyl cellulose, 5% of polyvinyl pyrrolidone, 1% of TiO ₂ and propyl alcohol were added to make 100%.

Comparative Example 1

Drug layer preparation solution: 22% polyvinyl pyrrolidone, 5% hydrogen peroxide, 1% sorbitan monooleate, 10% glycerin, 30% ethanol was added to make 100%.

Supporting layer preparation solution: 5% polyvinyl acetate, 5% glycerin, and ethanol were added to make 100%.

Comparative Example 2

Drug layer preparation solution: 20% Gantrez S-97, 15% sodium percarbonate, 3% propylene glycol, 1% l-menthol (flavor) and purified water were added to make 100%.

Support layer preparation solution: 16% ethyl cellulose, 8% castor oil, and ethanol were added to make 100%.

Comparative Example 3

Drug layer preparation solution: 20% polyethylene oxide (Polyox), 10% urea peroxide, 50% purified water, ethanol was added to 100%.

Support layer preparation solution: 15% of methacrylic acid copolymer, 20% of purified water, and ethanol were added to make 100%.

Comparative Example 4

Drug layer preparation solution: 10% of hydroxypropyl cellulose, 20% of hydroxyethyl cellulose, 3% of hydrogen peroxide, 3% of TSPP, 0.05% of sodium fluoride, 5% of glycerin, and water were added to make 100%.

Support layer preparation solution: 15% of cellulose acetate phthalate, 3% of SAPP, 30% of purified water, and ethanol were added to make 100%.

Comparative Example 5

Drug layer preparation solution: 5% polyvinyl alcohol, 6% tetrasodium pyrophosphate peroxidate, an appropriate amount of NaOH (up to pH 7), 5% glycerin, 1% TiO ₂ , and water were added to make 100%.

Supporting layer preparation solution: Ethyl cellulose 40%, polyethylene glycol 200 10%, ethanol was added to make 100%.

Experimental Example

Experimental Example 1 peel off test

Experiments were conducted on the ability of the intermediate layer to inhibit separation between the drug and support layers. The instrument was a slip / peel tester from Instrumentors Inc.

3 and 4 is a schematic diagram for explaining the peel off test (sheet) test of the formulations prepared according to Examples and Comparative Examples in Experimental Example 1 of the present invention, the teeth prepared according to the Examples The adherent formulation comprises a drug layer 2, an intermediate layer 3 and a support layer 4, whereas the formulation according to the comparative example consists of a drug layer 2 and a support layer 4. As shown here, the lower part of the drug layer (2) was firmly fixed with a double-sided tape (7) and the degree of layer separation was numerically evaluated when the end of the support layer (6) was pulled into the device. Larger value means no separation between layers. Table 1 shows the interlaminar separation force values of the patches prepared in Examples and Comparative Examples.

division Interlaminar Separation Force [gf / 25 mm] Remarks Example Example 1 85 10 times average Example 3 69 10 times average Comparative example Comparative Example 1 36 10 times average Comparative Example 3 15 10 times average

In Table 1 above, the patch prepared in Example was higher in the interlaminar separation force than that prepared in Comparative. In other words, it can be seen that the intermediate layer in the formulation of the present invention serves as an interlayer adhesive that suppresses layer separation.

In the conventional tooth-attachable product, the drug layer and the support layer are relatively easily peeled off for a long time, and thus, the marketability is poor. In order to improve this, the surfactant was added in Comparative Example 1, but the interlayer separation force value did not reach the example.

On the other hand, in the above results, Example 1 and Comparative Example 1 is higher in each group compared to Example 3 and Comparative Example 3 using the sorbitan monooleate as a surfactant in the positive direction between the layers It is interpreted because it was adjusted.

Experimental Example 2 Whitening Effect

The whitening effect of tooth-attached whitening patches was determined by the following method:

(1) Preparation of Contaminated Hydroxyapatite (HAP) Tablet Specimen

Tablets of hydroxyapatite powder were made by IR press, sintered at 1000 ° C, and then molded with epoxy resin to make a resin. The surface was etched with strong acid, and then in a TSP (trypticase soy broth) solution in which tea, coffee, iron and mucin were dissolved. The process of soaking and drying the specimens was repeated and this operation continued for one week to contaminate the specimens. The contaminated specimens were washed lightly with a toothbrush in running water to remove any contaminants that were easily dissolved or removed by water, and then dried at room temperature.

(2) whitening effect evaluation method

The initial L value of the contaminated HAP tablet specimens (L indicates brightness, white at 100 and black at 0) was measured with a colorimeter, and the tooth-attached whitening patch prepared in Examples and Comparative Examples was soaked in water. After attaching to the specimen, leave it in a thermo-hygrostat set to 37 ° C and 95% humidity to resemble the actual oral condition.After 4 hours, remove the tooth whitening patch and lightly brush it with running water and then room temperature. L value was measured by drying at. The difference ΔL of the L value before and after patching is calculated (ΔL means that the larger the value, the more effective the teeth whitening), and the results are shown in Table 2 below.

The following examples and comparative examples were measured after 3 months of manufacture in consideration of the period of circulation in the market.

division ΔL (Tooth Whitening Change) Remarks Example Example 2 36 10 times average Example 5 41 10 times average Comparative example Comparative Example 2 28 10 times average Comparative Example 5 19 10 times average

In Table 2, it can be seen that the tooth whitening change in the embodiment is larger, because it is determined that the peroxide among the tooth whitening component is more stably present in the product. In Example 2, l-menthol, which is highly reactive with peroxide, was used in the intermediate layer, whereby the reaction with hydrogen peroxide could be minimized. In addition, in Example 5, the reaction with hydrogen peroxide in the drug layer was minimized by adding TiO ₂ , which is used as an peroxide activator, to the intermediate layer. On the contrary, in Comparative Example 5, the tooth whitening effect was reduced because TiO ₂ reacted with the peroxide in the drug layer until the evaluation time after manufacture, thereby reducing the residual amount of the peroxide.

Experimental Example 3 Stability with Time

The time-dependent stability of hydrogen peroxide, a tooth whitening component, at high temperature (40 ° C.) in the tooth-attach whitening patch prepared in Examples and Comparative Examples was evaluated by the following method.

(1) Evaluation method of peroxide content in tooth whitening agent

Take a mixed solvent that can dissolve all layers of the patch in an Erlenmeyer flask, dissolve it completely by weighing the appropriate amount of patch correctly, add about 5 ml of 6 N hydrochloric acid and dissolve about 2 g of potassium iodide in a cool dark place 1 After leaving for about an hour, the peroxide content in the patch was quantified by titration with 50 mM sodium thiosulfate solution. The results are shown in Table 3 below. Here, the storage temperature was 40 ℃, the humidity was 75% constant temperature and humidity, and evaluated after 4 weeks storage in Al-Pouch.

division Hydrogen peroxide remaining amount (%) Remarks Example Example 1 91 10 times average Example 2 92 10 times average Example 4 89 10 times average Comparative example Comparative Example 1 71 10 times average Comparative Example 2 66 10 times average Comparative Example 4 54 10 times average

Herein, Comparative Examples 1, 2, and 4 contained sorbitan monooleate, l-menthol, and sodium fluoride, respectively, in the drug layer, compared with Examples, and these components reacted with hydrogen peroxide, resulting in poor stability over time. . On the other hand, Examples 1, 2 and 4 containing these components in the intermediate layer can be seen that excellent stability over time.

As described above, the tooth-adhesive whitening patch formulation consisting of a release agent, a drug layer, a support layer, and an intermediate layer as an agent used to attach to a tooth is positioned between the drug layer and the support layer to increase the binding force between these layers. Due to the intermediate layer that plays a role, not only the interlayer peeling phenomenon can be suppressed, but also the additives can be contained without inhibiting the stability over time, so that the whitening effect and the stability over time can also be improved.

1 is a schematic cross-sectional view showing a tooth attachment preparation having a three-layer structure according to the present invention,

Figure 2 is a schematic cross-sectional view showing a tooth attachment formulation having a structure of three or more layers according to the present invention,

Figure 3 is a schematic diagram for explaining the peel off test (peel off test) test of the formulation prepared according to Example in Example 1 of the present invention,

Figure 4 is a schematic diagram for explaining the peel off test (peel off test) test of the formulation prepared in Comparative Example 1 according to the present invention.

* Explanation of symbols for the main parts of the drawings

1: release agent 2: drug layer

3: intermediate layer 4: support layer

5: middle layer-1 6. end of support layer (handle)

7. Double sided tape

Claims (8)

A tooth sticking whitening agent for attaching to a tooth and delivering a drug, the tooth sticking whitening agent comprising a drug layer, a support layer, and an intermediate layer located between the drug layer and the support layer. The method of claim 1, wherein the interlayer comprises a peroxide activator, a pigment material, TiO ₂ , HAP (hydroxyapatite), flavoring, bad breath inhibitor, perceptual hypersensitivity agent, fluorine, gum disease agent, or mixtures thereof. Tooth-adhesive whitening agent. The tooth-adhesive whitening preparation according to claim 1, wherein the intermediate layer consists of a single layer or two or more layers. The toothpaste whitening preparation according to claim 1, wherein the drug layer is in the form of a dry type or a gel. The method of claim 1, wherein in the drug layer, the tooth whitening component is hydrogen peroxide, carbamide peroxide, calcium peroxide, sodium percarbonate, sodium perborate and fatigue peroxide. Sodium Phosphate (tetrasodium pyrophosphate peroxidate), Sodium Pyrophosphate (TSPP), Sodium acid pyrophosphate (SAPP), Sodium metaphosphate (SHMP), Sodium tripolyphosphate (STP), Sodium potassium tripolyphosphate (SKTP), potassium pyrophosphate (TKPP), acidic sodium meta-polyphosphate, acidic sodium polyphosphate, papain, vitamin E, sodium bicarbonate, suba A tooth-attach whitening agent comprising sodium chlorate, sodium hypochlorite, or a mixture thereof. A polyalkylvinylether-maleic acid copolymer (PVM / MA copolymer), polyvinyl alcohol, polyacrylic acid, poloxamer (poly (ethylene oxide) -poly (propylene oxide)- poly (ethylene oxide) triblock copolymer), polyethylene oxide, polyvinylpyrrolidone-vinylacetate copolymer (PVP / VA copolymer), polyvinylpyrrolidone (PVP), polyquaternium-11, poly Quaternium-39, carboxypolymethylene, hydroxypropylmethyl cellulose, hydroxyethyl cellulose, hydroxypropyl cellulose, gelatin, alginate, or mixtures thereof Tooth-adhesive whitening agent. The method of claim 1, wherein the support layer is a cellulose acetate phthalate, shellac, polyvinyl acetate, ethyl cellulose, poly methyl methacrylate, methacryloylethyl betaine / methacrylate copolymer as a polymer. A tooth-adhesive whitening agent comprising a copolymer, a methacrylic acid copolymer, an aminoalkyl methacrylate copolymer, or a mixture thereof. A polyalkylvinylether-maleic acid copolymer (PVM / MA copolymer), polyvinyl alcohol, polyacrylic acid, poloxamer (poly (ethylene oxide) -poly (propylene oxide) -poly (ethylene oxide) triblock copolymer), polyethylene oxide, polyvinylpyrrolidone-vinyl acetate copolymer (PVP / VA copolymer), polyvinylpyrrolidone (PVP), polyquaternium-11, polyquater Nium-39 (polyquaternium-39), carboxypolymethylene, hydroxypropylmethyl cellulose, hydroxyethyl cellulose, hydroxypropyl cellulose, gelatin, sodium alginate, cellulose acetate phthalate, shellac, polyacrylamide Vinyl acetate, ethyl cellulose, poly methyl methacrylate, methacryloylethyl betaine / methacrylate copolymer, methacryl A tooth sticking whitening agent comprising an acid copolymer, an aminoalkyl methacrylate copolymer, or a mixture thereof.