KR100942145B1 - Soap composition for acne treatment containing ginseng absolute essential oil - Google Patents

Abstract

The present invention reveals a potent acne treatment effect on ginseng extract, especially ginseng absolute essential oil, and discloses a soap composition for acne treatment comprising ginseng absolute essential oil. As a result of using the soap composition for acne treatment according to an embodiment of the present invention, it was confirmed that a strong acne treatment effect by blocking the growth and transmission of bacteria through excellent sebum removal action and effective sterilization of acne bacteria.

Ginseng Absolute, Acne, Soap, Acne Bacteria

Description

Soap composition for curing acne containing ginseng absolute oil}

The present invention relates to a soap composition for treating acne comprising ginseng absolute essential oil (精 ().

In general, acne is an inflammation of the hair follicles on the face, especially on the cheeks and forehead, and is more common in puberty. Acne occurs badly when the secretion of hormones such as androgens increases. Androgens cause sebaceous glands to become large, and the sebaceous glands are stimulated by androgens to enlarge and produce more sebum. Acne is caused by the hyperkeratinization of the hair follicles, causing the sebum to escape out of the tube, clogging the sebaceous gland clogging, sebum accumulates, gradually swells to the size enough to identify with the eye to form a scrim. Inside this cotton are grown anaerobic, sebum-loving acne bacteria (Propionibacterium acnes). Inflammation caused by acne bacteria can cause skin damage and cause secondary bacterial infections. In this case, the irritating ingredients of the general soap may further damage the skin by further expanding the initial inflammation and the secondary inflammation.

Therefore, the present inventors conducted systematic research experiments on various natural products to develop a substance having an acne treatment effect. As a result, ginseng extract, especially ginseng absolute, has a strong acne treatment effect, more specifically, bactericidal effect It has been found and completed the present invention. Accordingly, an object of the present invention is to provide a ginseng absolute essential oil-containing soap composition exhibiting a strong acne treatment effect by blocking the growth and transmission of bacteria through excellent sebum removal action and effective sterilization of acne bacteria.

The present invention provides a soap composition for treating acne comprising ginseng absolut essential oil.

As a result of using the soap composition for acne treatment according to an embodiment of the present invention, it was confirmed that a strong acne treatment effect by blocking the growth and transmission of bacteria through excellent sebum removal action and effective sterilization of acne bacteria.

The present invention relates to a soap composition for treating acne comprising ginseng absolute essential oil (精 ().

Examples of essential oils include distillation, extraction, and compression. Distillation is widely used because it is the simplest and most economical method, but it is not suitable to have a lot of water-soluble components or heat instability. The extraction method is a method used to extract a large amount of water-soluble components or heat instable. Squeezing is simply a way to squeeze out. In particular, the organic solvent extraction method is to extract the fragrance components by various solvents, which is different depending on the type of solvent. Not only volatile components but also nonvolatile components are simultaneously extracted. Specifically, flowers and the like are immersed in the solvent at room temperature, and the components are leached into the solvent. Subsequently, it is concrete obtained by removing solvent at low temperature, and the result obtained by adding fragrance ingredient by adding high purity alcohol to concrete and then evaporating alcohol is called absolute.

Soap composition according to an embodiment of the present invention can be prepared by a conventional manufacturing method including ginseng absolute essential oil as an active ingredient. The properties of the acne treatment soap composition according to the present invention is easy to apply to any of the different formulations, such as liquid, cream, paste or solid phase.

Cosmetically, pharmaceutically or dermatologically acceptable media that can be used according to one embodiment of the invention can be any media suitable for topical, topical, or parenteral administration known to those skilled in the art. have. Specifically, the medium may be an oily solution, a water-in-oil emulsion, an oil-in-water emulsion, a microemulsion, an oily gel, an anhydrous gel, or a dispersion of a vehicle, microcapsules or microparticles. Compositions according to one embodiment of the present invention may be administered by topical application.

In order to formulate the active ingredient of the present invention, it can be easily formulated according to the conventional method, and surfactants, excipients, coloring agents, spices, preservatives, stabilizers, buffers, suspending agents, and other commonly used auxiliaries can be suitably used.

In addition, the dosage of the active ingredient will vary depending on the age, sex and weight of the subject to be treated, the specific disease or pathology to be treated, the severity of the disease or pathology, the route of administration and the judgment of the prescriber. Dosage determination based on these factors is within the level of skill in the art.

Hereinafter, a preferred embodiment of the present invention related to the acne treatment soap composition will be described in more detail. However, the following embodiments are merely preferred embodiments of the present invention, and the present invention is not limited to such embodiments.

Example: Preparation of Ginseng Absolute Essential Oil

1) Fresh ginseng purchased from Geumsan Fresh Ginseng Market was washed with water, dried indoors, and then ground in a grinder. 45 kg of hexane (Hexane), 3 times the amount of pulverized ginseng, was added thereto, and the mixture was immersed at room temperature for 7 days and extracted twice.

2) The whole deposit was filtered through a 250 mesh filter, and then all ginseng residues were removed by passing through a 3 μm mesh → 1 μm mesh → 0.5 μm mesh filter.

3) Concentrated under reduced pressure at 40 ℃ using a rotary vacuum distillation to obtain 72g of ginseng concrete.

4) 72 g of the ginseng concrete was dissolved in 1 L of 95% EtOH, and then left for about a day. Filter by 5 filter paper. This was again passed through a 0.8 μm mesh → 0.45 μm mesh filter to completely remove the residue.

5) Ginseng absolute was prepared by concentration under reduced pressure at 50 ℃ using a rotary vacuum distillation.

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The characteristics of the ginseng absolute essential oil prepared in the above embodiment are shown in Table 1 below.

Item Characteristic Remarks oil Absolute ocean Brown fluid Scent Ginseng shell odor Refractive Index (n ²⁰ _D ) 1.450-1.550 Heavy metal content ≤20ppm Pass Arsenic (As) content ≤2ppm Pass Preservative Content none Microbial content ≤100cfu / ml Pass yield(%) 22 g (0.146%) Raw material 15kg

<Production example>
Using the ginseng absolute essential oil prepared in the above Example to prepare a soap composition with the ingredients and contents (% by weight) of Table 2.

ingredient Content (% by weight) Stearic acid 15 -20 wt% Lauric acid 5-10 wt% Myristic acid 2-6 wt% Triethanol amine 3-8 wt% Sodium Hydroxide 5-10 wt% Glycerin 8-15 wt% Sugar 8-15 wt% Sorbitol 8 -12 weight% Example 0.04 wt% Spices 1 wt% Triclosan 0.2-0.5 wt% Distilled Water to 100

<Test Example 1: Antibacterial activity test against acne bacteria ( P. acne ) of ginseng absolute essential oil>

The MIC (Minimal Inhibition Concentration) was measured in the laboratory using the Agar dilution method for the acne bacteria Propionibacterium acnes of ginseng absolute.

-Test Methods

(1) Prepare BHI (Brain Heart Infusion 37g / L, agar 1.5%) agar medium in the test tube.

(2) Sterilize test tubes and media.

(3) In the prepared medium, dilute ginseng absolute samples from 5% by weight concentration to serial dilution and dilute to 0.001% by weight.

(4) Pour into Petri dish to make Agar plate.

(5) Test bacteria (Acne bacteria, Propionibacterium acnes Streaking ATCC 6919 ) onto the medium.

(6) Incubate at least 72 hours in a 35 ℃ incubator for anaerobic bacteria culture.

(7) Observe growth.

-Test result

As can be seen in Table 3 and Figure 1 below showing the MIC results for acne bacteria, ginseng absolute is 0.01 for acne bacteria ( Propionibacterium acnes ) It exhibited antibacterial activity from the concentration of weight%. Therefore, it can be said that there is a significant antimicrobial activity.

density 0.001 weight% 0.01 weight% 0.1 weight% 1 weight% 5 wt% Growth growth No growth No growth No growth No growth

Test Example 2: Actual Usability Test

-Test Methods

A clear soap was made according to the prescription of Table 2, and a usability test was conducted on 20 acne patients. The test period was four weeks, and no other soaps were used. Only soaps prepared as prescribed in Table 2 were used twice a day. Every week, we took a questionnaire to check the effect and took pictures. The questionnaire content was to answer the question "Inflammation / No change / Improved / Significantly improved" for inflammation, redness and sebum secretion.

-Test result

The effect was confirmed after 2 weeks of use, and after 4 weeks there was a clear difference. In other words, a lot of large cotton cloth disappeared, redness, sebum due to sebum was also reduced a lot.

Although the present invention has been described in connection with the above-mentioned preferred embodiments, it is possible to make various modifications or variations without departing from the spirit and scope of the invention. Accordingly, the appended claims will cover such modifications and variations as fall within the spirit of the invention.

1 is acne bacteria ( Protonibacterium) acnes ) shows the MIC results.

Claims (5)

0.01 to 5% by weight of ginseng absolute oil, 15 to 20% by weight of stearic acid, 5 to 10% by weight of lauric acid, 2 to 6% by weight of myritic acid, triethanolamine ) 3 to 8% by weight, 5 to 10% by weight sodium hydroxide, 8 to 15% by weight glycerin, 8 to 15% by weight sugar, 8 to 12% by weight sorbitol, flavoring A transparent soap composition for treating acne, comprising 1% by weight and 0.2-0.5% by weight of triclosan, and comprising distilled water so that the sum is 100% by weight, the weight% being based on the total weight of the composition. According to claim 1, wherein the ginseng absolute essential oil is a transparent soap composition for treating acne is contained 0.04% by weight of the total composition. The transparent soap composition of claim 1 or 2, wherein the composition has a liquid, cream, paste or solid formulation. According to claim 1 or 2, wherein the ginseng absolute essential oil is a clear soap composition for treating acne having a bactericidal effect ( Pionibacterium acnes ). According to claim 1 or 2, wherein the ginseng absolute essential oil is a brown fluid, ginseng shell odor, refractive index (n ²⁰ _D ) is 1.450 to 1.550, heavy metal content is 20 ppm or less, arsenic content is 2 ppm Or less, the microorganism content is 100 cfu / ml transparent soap composition for the treatment of acne.

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