JPS63239208A - Beauty or skin composition containing silymarine-rich extract of silybum marianum fruit and essential fatty acid - Google Patents

Abstract

(57) [Summary] This bulletin contains application data before electronic filing, so abstract data is not recorded.

Description

DETAILED DESCRIPTION OF THE INVENTION Field of the Invention The present invention relates to a novel cosmetic or dermatological composition comprising an extract of milk thistle fruit rich in silymarin and essential fatty acids.

Prior Art Milk thistle extract, called "hawthorn absolinate", is a substance that inhibits the formation of free radicals.

A free radical is an atom or molecule that has temporarily captured a "lone" electron. This unpaired electron, which is not paired with an opposite spin, makes the free radical extremely reactive. That is, since free radicals are highly reactive with surrounding molecules, these surrounding molecules in turn become free radicals.

This mechanism can explain the enormous toxicity of these "excited molecules." In other words, free radicals attack the main components of cells: the nucleus, proteins, and cell membranes. Among these, cell membranes are particularly attacked.

Incidentally, essential fatty acids, which are constituents of phospholipids in cell membranes, are particularly vulnerable to free radicals at their double bonds.

Problems to be Solved by the Invention Carbon-carbon double bonds are evidence of the structure and hardness of cell membranes. The presence of free radicals not only weakens the membrane by cracking and bending it, but also reduces its fluidity, reducing its ability to control the movement of ions.

Changes in the membrane like this affect the metabolism of the cell. As protection for cells weakens, oxygen supply decreases, and nutrients become less available, cells gradually lose their ability to proliferate, harden, and then die. in this way,
Free radicals and the resulting peroxidation process contribute to cellular aging,
Therefore, it plays an important role in skin aging.

For this reason, it is of great importance to combine cosmetic or dermatological compositions called ``hawthorn absolinate'', which are highly effective scavengers of free radicals and have anti-aging properties, with essential fatty acids that have restorative properties. .

Means for Solving the Problems Therefore, according to the present invention, there is provided a cosmetic or dermatological composition for skin care, which comprises as a main component: A) an extract of milk thistle fruit rich in silymarin; B) in any of the following forms, namely: - in the form of free radicals (1), - in the form of alkali metal or ammonium salts (2), - in the form of triglycerides; Form (3), or a mixture of two of the above three forms (1), (2), and (3), or a mixture of all three forms, with 18 carbon atoms Compositions are provided that are characterized in that they contain a mixture of one or more essential polyunsaturated fatty acids comprising ˜22 essential polyunsaturated fatty acids.

The invention particularly provides that component B) is present in the free radical form (1), in the triglyceride form (3), and in the triglyceride form (3).
) is simultaneously present in the form (2) of an alkali metal salt or ammonium salt obtained by saponifying all or part of In addition, other substances called free radical scavengers are added to component A) of the composition of the present invention to produce the composition "Hawthorn Abso'J s
-) It is extremely reasonable to reinforce the effect of J.

Examples of substances added in this case include olefinic, acrylic, and cyclic terpenes of essential oils, alcohol derivatives thereof, and flavonoids. Looking at the molecular structure, it can be seen that these compounds function as free radical scavengers.

Furthermore, it is possible to add, for example, vitamin E1 or alpha-tocopherol, vitamin C1, vitamin A1 and derivatives of these vitamins, whose antioxidant and anti-free radical functions have been described in various documents.

The invention therefore particularly relates to a composition characterized in that component A) further comprises essential oil terpenes, flavonoids and alpha-tocopherol.

According to the invention, the main components further include: - 10 to 30% by weight of extract of milk thistle; - 5 to 1% of terpenes of essential oil;
- 5-15% by weight of flavonoids; - 5-20% by weight of α-tocopherol; - 25-40% by weight of triglycerides of essential fatty acids (3); - in free radical form, preferably γ- Essential fatty acids in the form of linolenic acid (1) and essential fatty acids in the form of alkali metal or ammonium salts (2N
0.5-10% by weight of a mixture containing O-25% by weight
A composition comprising:

The above mixture containing 25 to 40% borage oil is SKINAVENGER.
The name is registered as a trademark.

In the above composition, γ-linolenic acid in the form of an alkali metal salt or an ammonium salt is preferably obtained by saponification of the oil of a plant of the genus evening primrose.

The present invention further provides the following main components: - 1 to 10% by weight of oil of a plant of the genus Evening Primrose; - 5% (dry extract of) the defatted fruit of milk thistle; - 0 α-tocopherol contained in polyethylene glycol. .05 to 2% by weight; and 1 to 10% by weight.

In particular, the present invention provides as main components - 5% by weight of oil of a plant of the genus Evening Primrose; - 5% (dry extract of) defatted fruit of milk thistle; - 1% by weight of α-tocopherol contained in polyethylene glycol. - 1 to 10% by weight of an ultraviolet screening agent for UVA-UVB; - 1 to 10% by weight of an extract of pancreas.

A mixture consisting of 5% dry extract of defatted fruit of Sylvum marianum and 1% by weight of α-tocopherol in polyethylene glycol contains flavopherols (
The trademark is registered under the name FLAVOP)IBROL).

The above compositions have the advantage that certain substances soluble in the oil phase and other substances soluble in the aqueous phase can be mixed equally well in component A) and in component B).

For example, "hawthorn absolute" is water-soluble, and essential oils such as terpenes, flavonoids, and alpha-tocopherol are oil-soluble. Similarly, triglycerides of essential fatty acids are oil-soluble, whereas essential fatty acids in free or salt form are water-soluble.

The essential fatty acid triglycerides in component B) above are synthetic, common triglycerides.

Such triglycerides can also be obtained from one or more sources that naturally contain the triglycerides. Such raw materials are primarily vegetable oils.

By way of example, mention may be made of wheat germ oil, olive oil, corn oil, sunflower oil, almond oil, oil of evening primroses, oil of the genus Oenothera, oil of black currant seeds. All of these oils contain varying proportions of one or more essential fatty acids.

Saponification of triglycerides is carried out in a conventional manner. In particular, alkali metal hydroxides (soda or potash) are used in this reservoir.

This saponification treatment is carried out in the presence of an antioxidant, considering that polyunsaturated fatty acids are extremely susceptible to oxidation.

The polyunsaturated fatty acids present in the form of alkali metal salts in component B) are preferably sodium or potassium salts.

There are two types of essential polyunsaturated fatty acids. One is γ-linolenic acid and the other is linuric acid.

The most abundant essential fatty acids in the skin include lylunic acid as a precursor, which is converted metabolically as follows.

C18:2 → C18:3 → Lilunic acid γ-linolenic acid → C20: 3 → C20:4 Dihomoγ-linolenic acid Arachidonic acid All these acids are essential for normal tissue growth and physiological activities. .

Oils rich in the essential fatty acids in the form of triglycerides listed above include sunflower oil (57% lylunic acid), corn oil (40% lylunic acid), evening primrose oil (71% lylunic acid and 9% gamma-linolenic acid). %), borage oil, and black currant seed oil.

In humans, there are significant restrictions on the conversion of linolenic acid to γ-linolenic acid, and there are many external factors that make this conversion impossible. In particular, this conversion becomes less efficient as we age.

Among the essential fatty acids mentioned above, r-linolenic acid is particularly important.

According to the invention, in particular component B) comprises γ-linolenic acid (1) in free radical form and an oil (3) obtained from a raw material rich in γ-linolenic acid; There is provided a composition characterized in that it is a mixture consisting of the alkali metal salt or ammonium salt (2) of r-linolenic acid obtained by saponification of (3).

Evening primrose ([1eno
thera Bienis) or evening primrose (
Oenothera Bienis Lamarkia
Oil extracted from seeds of Na), borage oil, and oil of black currant seeds are three important vegetable oils rich in γ-linolenic acid.

Oils containing r -IJ phosphoric acid that can be used in the compositions of the present invention can further include oils obtained by extracting fungi of the order Siphomycetes, maple seeds, or hops.

Of course, all other oils extracted from natural sources containing gamma-linolenic acid can also be used.

The invention particularly provides that component B) is γ-
Linolenic acid (1) and evening primrose (7) oil (3)
) and an alkali metal salt of r-linolenic acid (2) obtained by saponification of oil (3) of a plant belonging to the genus Evening Primrose.

The compositions of the invention may contain any known skin-effective substances. Such a substance is
Collagen, elastin, hyaluronic acid and humectants such as urea, carboxypyrrolidonic acid and its salts, as well as vitamin extracts, fragrances, preservatives, colorants, pancreatic or thymus extracts, jojoba oil, shea butter, gamma - oryzanol.

Since UV radiation plays an important role in the formation of free radicals in the skin, the above compositions may also contain small amounts of UV filters or screening agents. For example, as a filter for UVA and UVB radiation, mention may be made of 2-hydroxy-4-methoxypunzophene, 3,4-dimethoxyphenylglyoxylic acid in the form of its sodium salt.

The compositions of the invention can be provided in any form used in cosmetology. For example, creams or gels in bottles or tubes, emulsions or lotions in glass or plastic vials, or vials with a liquid meter, i.e. a vial with a device that allows you to count the number of droplets. , or even provided in ampoules or aerosol cylinders.

The present invention relates to a cosmetic or dermatological composition characterized in that it is in the form of a skin cream, gel, emulsion, skin bag or lotion, and in particular, the present invention relates to a cosmetic or skin composition characterized in that it is in the form of a skin cream, gel, emulsion, skin bread-like bag, or lotion. Concerning compositions suitable for application to the neck.

In fact, appropriate adjuvants are used depending on the form of the composition. The supplement must have all the properties normally required. This supplement must have a high affinity for the skin, be completely tolerated and stable, and have a consistency that is easy to use and pleasant.

Possible adjuvants include, for example, glycerol stearate, propylene glyconopepalmitate and stearate derivatives, lanolin, glycerin, cetyl alcohol, polyalcohols, commonly used animal fats, inorganic substances, waxes, Examples include surfactants, thickeners, stabilizers, and emulsifiers.

Methods commonly used in this field can be used to form the above-mentioned various forms used in cosmetology.

Components A) and B) of the invention can be incorporated into the abovementioned adjuvants and substances effective for the skin, taking into account their affinity for the oily or aqueous phase.

Generally, component B) is incorporated at the same time as the start of emulsification.

Component A) is only added after emulsification has finished and at a temperature below 35°C.

EXAMPLES The following examples are merely examples of the present invention, and the present invention is not limited to these examples.

Example 1 Fluid gel Neutralized carboxyvinyl polymer 0.25-0.65 g Carboxymethyl cellulose sodium salt 0.02-0
．． 5 g Propylene glycol 1-5 g Polyglyceryl methacrylate gel 5-10 g Verhydrosqualene 1-5 g γ-Oryzanol 0.05-2 g α-Bisporol 0.05-1 g Skinavenger® 1-5 g High molecular weight peptides 1-5
g Hyaluronic acid 0° (11-0.
05 g Preservative Enough amount Flavoring Enough amount Coloring agent
Sufficient amount of purified water
Example 2 0/W type fluid emulsion Stearic acid 0.5-2.5 g Propylene glycol fatty acids 1-5 g Perhydrosqualene 1-5 g Shea butter or cocoa butter 1-5 g Obtained from animals Polypeptide 0.1-1g Technical fatty acid ester 2-12gUVA/UV
Filter for B 0.5-1.5g α-Bisporol 0.05-1g Vegetable oil
1-5gγ-oryzanol 0.
05-0.5g Skinavenger (registered trademark) 1-5
g Hyaluronic acid 0. (11~0.
05 g Neutralized carboxymethyl cellulose 0.1-1 g Propylene glycol 3-12 g Urea 0.5-5 g Preservative
enough fragrance
Sufficient amount of purified water Total 10
Example 3 0/W type cream emulsifier-P, 0. [E, fatty acid ester-P, 0. B. Carbohydrate 2-7g - Phospholipid silicone oil 0.5-5g Vegetable 1
0.2-1g Verhydrosqualene 1-5'g UVA/UVB filter
0.5-1.5g cetyl alcohol
0.2-1g vegetable oil 1-5g
Plant sterols 1-2.5g γ-oryzanol 0.05-0.5g Triethanolamine 0.3-2g Proteins obtained from animals 1-5g Skinavenger (registered trademark)
1-5g hyaluronic acid 0. (11
~0.05g Neutralized carboxyvinyl polymer 0.3-0.8g Urea 0.5-5g Preservative
enough fragrance
Sufficient amount of purified water Until the total amount is 100g Example 4 W10 type cream glycerol and sorbitan instearate 10 ~
12 g Verhydrosqualene 10-15 g2
-Ethylhexyl succinate 10-15 g Avocado oil 3-6 g White wax
3-5g T-oryzanol
0.05-0.5g microcrystalline wax
1-3g Skinavenger (registered trademark) 1-5
g Hyaluronic acid 0. (11~0.
03 g Glycerin 2-5 g Magnesium sulfate (MgSO, 7H20) 0.7 g Preservative Sufficient amount Fragrance
Sufficient amount of purified water
Until the total amount is 100 g Example 5 Di-cream/facial care cream Sorbitan palmitate 6.0 g Glyceride of fatty acid 13.0 g Wais' 4.0 g Oxybenzene 1.0 g Evening Primrose oil 5.0 g Sorbitol
3.0g neutralized carboxyvinyl polymer 0.5g pancreatic tissue extract
3.0g Flavopherol (registered trademark)
5.0 g preservative
Sufficient amount of aromatic composition
Sufficient amount of purified water until the total amount is 100g Example 6 Warming Day Cream P, 0. B, cetyl ether 3.
5g sorbitan stearate 3.5g
Triglycerides of fatty acids 5g Verhydrosqualene 2g Hydrogenated lanolin
5g evening primrose oil
5g UVA/UVB UV screening agent 2
g Propylene glycol 5 g Flavopherol® 3 g Sodium pyrrolidone carboxylate 2 g Neutralized carboxyvinyl polymer 1 g Preservative
Fully coulometric aromatic composition
Sufficient amount of purified water Total 10
Example 7 Care Cream Glycerol and PEG100 Stearate 6g Shea Butter 5g Evening Primrose Oil 5g Cetyl Alcohol
2g fatty acid triglyceride
8g vitamin A
0.5 g extract from an organism
5g Flavopherol (Registered Trademark 41) 5
g Glycerin 5g Neutralized carboxyvinyl polymer 1g Preservative
Sufficient amount of aromatic composition
Sufficient passionate water production total 1
Example 8 AGE in the form of facial gel liposomes 0.5
gFlavoferol (registered trademark) 3g Sodium pyrrolidone carboxylate 2g Preservative
Sufficient amount of aromatic composition
Sufficient amount of neutralized carboxyvinyl polymer 1.5g propylene glycol
5g purified water total 100g
Example 9 Sunburn prevention cream Vaseline oil 5g silicone oil 1g fatty acid ester
5g lanolin derivative
8g chrycerol and PEG100 stearate

Claims (15)

[Claims] (1) A cosmetic or dermatological composition for skin care, which contains as a main ingredient A) milk thistle (Silybum Marianum) rich in silymarine;
Hawthorn absolute (A
B) - Free radical form (1), - Alkali metal salt or ammonium salt form (2), - Triglyceride form (3), - The above three forms (1). ), (2), (3) or in the form of a mixture of all three of these forms, containing one or more essential polyols containing from 18 to 22 carbon atoms. A composition characterized in that it comprises a mixture with saturated fatty acids. (2) The essential polyunsaturated fatty acids (2) in the form of alkali metal or ammonium salts are triglycerides (
The composition according to claim 1, which is obtained by saponifying all or part of 3). (3) The above essential fatty acids include wheat germ oil, olive oil,
3. The oil according to claim 1 or 2, characterized in that it is obtained from a vegetable oil selected from the group consisting of corn oil, sunflower oil, sweet almond oil, oil of evening primrose plants, oil of chinensis, and oil of black currant seeds. Composition. (4) Component B) comprises γ-linolenic acid (1) in the form of free radicals, an oil (3) obtained from a raw material rich in γ-linolenic acid, and the form of an alkali metal salt or ammonium salt. The composition according to any one of claims 1 to 3, characterized in that it is a mixture consisting of γ-linolenic acid (2). (5) The above-mentioned oil obtained from raw materials rich in γ-linolenic acid is mixed with oil of evening primrose plants, oil of evening primrose, oil of black currant seeds, and fungi of the order Siphomycetes and the order Spirulinae (
champions siphomycetes,
5. Composition according to claim 4, characterized in that it is selected from the group comprising oils obtained by extraction of hops, maple seeds or hops. (6) The composition according to any one of claims 1 to 5, wherein the component A) further contains a terpene of an essential oil. (7) The composition according to any one of claims 1 to 6, wherein the component A) further contains a flavonoid. (8) The composition according to any one of claims 1 to 7, wherein the component A) further contains α-tocopherol. (9) As main components: - 10-30% by weight of milk thistle extract; - 5-15% by weight of essential oil terpenes; - 5-15% by weight of flavonoids; - 5-20% by weight of α-tocopherol; - 25 to 40% by weight of the essential fatty acid triglyceride (3); - the essential fatty acid (1) in free radical form, preferably in the form of γ-linolenic acid, e.g. by saponification of all or part of the triglyceride (3); Essential fatty acids in the form of alkali metal or ammonium salts that can be obtained (2)
9. A composition according to any one of claims 1 to 8, characterized in that it comprises 0.5 to 10% by weight of a mixture comprising 10 to 25% by weight. (10) The composition according to claim 9, characterized in that borage oil is contained as the essential fatty acid triglyceride (3). (11) Composition according to claim 10, characterized in that said essential fatty acid (2) in the form of an alkali metal salt or an ammonium salt is obtained by saponification of the oil of a plant of the genus evening primrose. (12) Component B) is γ-linolenic acid obtained by saponification of γ-linolenic acid (1) in the form of free radicals, evening primrose plant oil (3), and evening primrose plant oil (3). The composition according to any one of claims 1 to 8, characterized in that it is a mixture consisting of an alkali metal salt of an acid (2). (13) Main ingredients: - 1 to 10% by weight of evening primrose oil; - 5% (dry extract) of milk thistle defatted fruit;
Claims 1 to 8 comprising a mixture containing 0.05 to 2% by weight of α-tocopherol contained in polyethylene glycol and 1 to 10% by weight.
and 12. The cosmetic or dermatological composition for skin care according to any one of Items 12 and 12. (14) Main ingredients: - 5% by weight of evening primrose oil; - 5% (dry extract) of milk thistle defatted fruit;
5% by weight of a mixture with 1% by weight of α-tocopherol contained in polyethylene glycol; - 1-10% by weight of an ultraviolet screening agent for UVA-UVB; - 1-10% by weight of a spleen extract. Claims 1 to 8 comprising a mixture.
The composition according to any one of , 12 and 13. (15) The composition according to any one of claims 1 to 14, which is in the form of a cream, gel, emulsion, or lotion for the skin.