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JPS54145658A - Novel substituted benzamide*its manufacture and psychotropic drug as active component thereof - Google Patents

Novel substituted benzamide*its manufacture and psychotropic drug as active component thereof

Info

Publication number
JPS54145658A
JPS54145658A JP548379A JP548379A JPS54145658A JP S54145658 A JPS54145658 A JP S54145658A JP 548379 A JP548379 A JP 548379A JP 548379 A JP548379 A JP 548379A JP S54145658 A JPS54145658 A JP S54145658A
Authority
JP
Japan
Prior art keywords
manufacture
active component
novel substituted
psychotropic drug
substituted benzamide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP548379A
Other languages
English (en)
Other versions
JPS6049192B2 (ja
Inventor
Tomine Mishieru
Ashie Jiyatsuku
Kuroodo Monie Jiyan
Original Assignee
Ile De France
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ile De France filed Critical Ile De France
Publication of JPS54145658A publication Critical patent/JPS54145658A/ja
Publication of JPS6049192B2 publication Critical patent/JPS6049192B2/ja
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
    • C07D207/09—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyrrole Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
JP54005483A 1978-01-20 1979-01-19 新規置換ベンズアミド、その製造方法及びこれを有効成分とする向精神薬 Expired JPS6049192B2 (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR7801632 1978-01-20
FR7801632A FR2415099A1 (fr) 1978-01-20 1978-01-20 Nouveaux derives de 4-amino-5-alkylsulfonyl ortho-anisamides, leurs procedes de preparation et leur application comme psychotropes

Publications (2)

Publication Number Publication Date
JPS54145658A true JPS54145658A (en) 1979-11-14
JPS6049192B2 JPS6049192B2 (ja) 1985-10-31

Family

ID=9203689

Family Applications (1)

Application Number Title Priority Date Filing Date
JP54005483A Expired JPS6049192B2 (ja) 1978-01-20 1979-01-19 新規置換ベンズアミド、その製造方法及びこれを有効成分とする向精神薬

Country Status (42)

Country Link
US (2) US4294828A (ja)
JP (1) JPS6049192B2 (ja)
AR (2) AR221354A1 (ja)
AT (1) AT377977B (ja)
AU (1) AU528561B2 (ja)
BE (1) BE872585A (ja)
BG (2) BG31497A3 (ja)
CA (1) CA1101430A (ja)
CH (1) CH637927A5 (ja)
CS (1) CS226181B2 (ja)
CY (1) CY1201A (ja)
DD (1) DD141520A5 (ja)
DE (1) DE2901181C2 (ja)
DK (1) DK158346C (ja)
EG (1) EG14045A (ja)
ES (2) ES476755A1 (ja)
FI (1) FI71126C (ja)
FR (1) FR2415099A1 (ja)
GB (2) GB2012765B (ja)
GR (1) GR64431B (ja)
HK (1) HK12184A (ja)
HU (1) HU179793B (ja)
IE (1) IE47798B1 (ja)
IL (1) IL56411A (ja)
IN (1) IN150226B (ja)
IT (1) IT1164655B (ja)
LU (1) LU80786A1 (ja)
MC (1) MC1232A1 (ja)
MX (2) MX5793E (ja)
NL (1) NL191707C (ja)
NO (1) NO151320C (ja)
NZ (1) NZ189378A (ja)
OA (1) OA06156A (ja)
PH (2) PH15725A (ja)
PL (2) PL118151B1 (ja)
PT (1) PT69068A (ja)
RO (2) RO76393A (ja)
SE (2) SE448874B (ja)
SU (1) SU820659A3 (ja)
YU (2) YU42172B (ja)
ZA (1) ZA79219B (ja)
ZM (1) ZM579A1 (ja)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2013522181A (ja) * 2010-03-11 2013-06-13 アカシア ファーマ リミテッド 鎮吐薬としてのアミスルプリドの使用
JP2019533700A (ja) * 2016-11-01 2019-11-21 アカシア ファーマ リミテッドＡｃａｃｉａ Ｐｈａｒｍａ Ｌｉｍｉｔｅｄ アミスルプリドによる術後嘔吐の治療法

Families Citing this family (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2440946A2 (fr) * 1978-01-20 1980-06-06 Ile De France Nouveaux benzamides heterocycliques substitues, leurs procedes de preparation et leur application comme modificateurs du comportement
NZ199080A (en) * 1980-12-12 1984-07-31 Beecham Group Ltd 2-alkoxy-4-amino-5-alkylsulphonyl-n-(3beta-(8-hydrocarbyl-8-azabicyclo (3,2,1)octyl))benzamides
FR2550447B1 (fr) * 1983-08-10 1986-01-17 Ile De France Application du n-(ally-2-pyrrolidinylmethyl) 2-methoxy 4-amino 5-methylsulfamoyl benzamide comme antiagregant plaquettaire
FR2574795B1 (fr) * 1984-12-18 1987-11-20 Ile De France Nouveau procede industriel de synthese du n-((1'-allyl 2'-pyrrolidinyl) methyl) 2-methoxy 4,5-azimido benzamide
FR2584401B1 (fr) * 1985-07-04 1987-11-20 Ile De France Nouveau benzamide, son procede de preparation et son application dans le domaine therapeutique
US5227388A (en) * 1989-12-26 1993-07-13 Hoechst-Roussel Pharmaceuticals Incorporated Thienobenzoxepins and naphthothiophenes
US5260319A (en) * 1989-12-26 1993-11-09 Hoechst-Roussel Pharmaceuticals Incorporated Thienobenzoxepins and naphthothiophenes
FR2678266A1 (fr) * 1991-06-28 1992-12-31 Delagrange Laboratoires Nouveaux derives de 2-hydroxy 4-amino 5-ethylsulfonyl benzamide utiles comme anxiolytiques.
FR2699533A1 (fr) * 1992-12-21 1994-06-24 Mouhtaram Mohamed Dérivés de N-((1,4-dialkyl-6-arylpipérazine-2-yl)méthyl)benzamides. (Isomères cis et trans) Propriétés pharmacologiques et applications.
FR2753376B1 (fr) * 1996-09-18 1998-10-16 Synthelabo Compositions pharmaceutiques comprenant de l'amisulpride et leurs applications therapeutiques
FR2762213B1 (fr) * 1997-04-18 1999-05-14 Synthelabo Composition pharmaceutique a retention gastrique
US6169094B1 (en) 1998-07-14 2001-01-02 Sanofi-Synthelabo Compositions of (S) (-)-amisulpride
EP2147679B1 (en) 2001-07-25 2014-06-25 Raptor Pharmaceutical, Inc. Compositions for blood-brain barrier transport
WO2004100992A2 (en) * 2003-05-16 2004-11-25 Pfizer Products Inc. Therapeutic combinations of atypical antipsychotics with gaba modulators, anticonvulsants or benzodiazapines
FR2857263B1 (fr) * 2003-07-09 2005-09-09 Sanofi Synthelabo Nouvelle composition pharmaceutique solide comprenant de l'amisulpride
BRPI0510942A (pt) * 2004-05-11 2007-07-17 Pfizer Prod Inc combinação de antipsicóticos atìpicos e antagonistas do receptor 5-ht1b
JP2008538582A (ja) * 2005-04-22 2008-10-30 ワイス 精神病性障害の治療または予防のための新規の治療的組み合わせ
CN103259027A (zh) 2005-04-28 2013-08-21 普罗透斯数字保健公司 药物信息系统
CN101594878A (zh) 2006-09-18 2009-12-02 雷普特药品公司 通过给予受体相关蛋白（rap）-缀合物对肝病症的治疗
US7825156B2 (en) * 2007-02-02 2010-11-02 Copharms Method of treating bipolar depression with a benzamide derivative
WO2009156889A1 (en) * 2008-06-25 2009-12-30 Pfizer Inc. Diaryl compounds and uses thereof
US20100105755A1 (en) * 2008-09-12 2010-04-29 Auspex Pharmaceuticals, Inc. Substituted benzamide modulators of dopamine receptor
AU2010216512B2 (en) 2009-02-20 2016-06-30 2-Bbb Medicines B.V. Glutathione-based drug delivery system
KR20180114970A (ko) 2009-05-06 2018-10-19 라보라토리 스킨 케어, 인크. 활성제-칼슘 포스페이트 입자 복합체를 포함하는 피부 전달 조성물 및 이들을 이용하는 방법
CN101898991B (zh) * 2009-05-31 2013-09-25 江苏天士力帝益药业有限公司 一种(s)(-)-氨磺必利d-(-)-酒石酸盐的合成方法
CN101628886B (zh) * 2009-08-25 2012-12-12 北京紫萌同达科技有限公司 一种2-甲氧基-4-氨基-5-乙砜基苯甲酸的合成方法
AU2016216578B2 (en) * 2010-03-11 2017-11-23 Acacia Pharma Limited The use of amisulpride as an anti-emetic
AU2014202535B2 (en) * 2010-03-11 2016-05-26 Acacia Pharma Limited The use of amisulpride as an anti-emetic
MX2012014497A (es) 2010-06-17 2013-04-03 Lupin Ltd Un proceso mejorado para la preparación de amilsuprida.
US20120077778A1 (en) 2010-09-29 2012-03-29 Andrea Bourdelais Ladder-Frame Polyether Conjugates
CN103304453A (zh) * 2013-06-18 2013-09-18 苏州诚和医药化学有限公司 两步法合成2-甲氧基-4-氨基-5-乙砜基苯甲酸
CN103319384A (zh) * 2013-06-18 2013-09-25 苏州诚和医药化学有限公司 制备2-甲氧基-4-氨基-5-乙砜基苯甲酸的方法
CN103450058B (zh) * 2013-09-18 2015-10-14 广安凯特医药化工有限公司 一种氨磺必利酸的制备方法
CN104725292B (zh) * 2015-03-23 2017-07-25 湖北荆江源制药股份有限公司 一种(s)(‑)‑氨磺必利的制备方法
US11377421B2 (en) 2016-11-28 2022-07-05 Lb Pharmaceuticals Inc. Psychotropic agents and uses thereof
CN110248655B (zh) * 2016-11-28 2023-07-07 Lb制药公司 精神药剂及其用途
CN106995397B (zh) * 2016-12-12 2020-01-14 河北医科大学 R-氨磺必利药用盐、制备方法、晶型及其用途
GB201702250D0 (en) 2017-02-10 2017-03-29 Acacia Pharma Ltd Method
EP3720434A4 (en) 2017-12-05 2021-09-01 Sunovion Pharmaceuticals Inc. NON-RACEMIC MIXTURES AND THEIR USE
AU2018378348B2 (en) 2017-12-05 2024-09-19 Sunovion Pharmaceuticals Inc. Crystal forms and production methods thereof
CN110790693A (zh) * 2018-08-02 2020-02-14 北京万全德众医药生物技术有限公司 一种(s)(-)-氨磺必利的制备方法
BR112021024380A2 (pt) 2019-06-04 2022-04-19 Sunovion Pharmaceuticals Inc Formulações de liberação modificadas e usos das mesmas

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3342826A (en) * 1964-01-13 1967-09-19 Ile De France Heterocyclic aminoalkyl benzamides
FR2313935A1 (fr) * 1975-06-10 1977-01-07 Ile De France Nouveaux benzamides substitues, leurs derives et leur procede de preparation
US3862139A (en) * 1972-06-23 1975-01-21 Delmar Chem Heterocyclic benzamide compounds
FR2244760B1 (ja) * 1973-09-25 1980-06-27 Ile De France
FR2299862B1 (fr) * 1975-02-07 1978-07-21 Ile De France Nouveau
FR2294698A1 (fr) * 1974-12-18 1976-07-16 Synthelabo Nouveaux derives des methoxy-2 benzamides substitues, leurs sels, leur preparation et les medicaments qui en renferment
CA1039731A (en) * 1974-12-18 1978-10-03 Synthelabo Process for preparing new 2-methoxy-benzamide derivatives

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2013522181A (ja) * 2010-03-11 2013-06-13 アカシア ファーマ リミテッド 鎮吐薬としてのアミスルプリドの使用
JP2016028090A (ja) * 2010-03-11 2016-02-25 アカシア ファーマ リミテッドＡｃａｃｉａ Ｐｈａｒｍａ Ｌｉｍｉｔｅｄ 鎮吐薬としてのアミスルプリドの使用
JP2019533700A (ja) * 2016-11-01 2019-11-21 アカシア ファーマ リミテッドＡｃａｃｉａ Ｐｈａｒｍａ Ｌｉｍｉｔｅｄ アミスルプリドによる術後嘔吐の治療法
JP2023058654A (ja) * 2016-11-01 2023-04-25 アカシア ファーマ リミテッド アミスルプリドによる術後嘔吐の治療法

Also Published As

Publication number Publication date
IN150226B (ja) 1982-08-21
NL7900457A (nl) 1979-07-24
ZM579A1 (en) 1979-12-21
NO790180L (no) 1979-07-23
YU25483A (en) 1983-10-31
EG14045A (en) 1983-09-30
ATA39879A (de) 1983-12-15
IL56411A (en) 1982-09-30
YU41278B (en) 1986-12-31
IL56411A0 (en) 1979-03-12
CA1101430A (en) 1981-05-19
PH22287A (en) 1988-07-22
NO151320B (no) 1984-12-10
NZ189378A (en) 1983-03-15
DK20979A (da) 1979-07-21
SE448874B (sv) 1987-03-23
FI71126C (fi) 1986-11-24
RO80311A (ro) 1982-12-06
OA06156A (fr) 1981-06-30
GB2083458A (en) 1982-03-24
JPS6049192B2 (ja) 1985-10-31
YU42172B (en) 1988-06-30
PL212899A1 (ja) 1980-01-14
SE460968B (sv) 1989-12-11
SU820659A3 (ru) 1981-04-07
IE790092L (en) 1979-07-20
DK158346C (da) 1990-10-08
DK158346B (da) 1990-05-07
CS226181B2 (en) 1984-03-19
AR221354A1 (es) 1981-01-30
MC1232A1 (fr) 1979-10-26
MX7623E (es) 1990-03-27
NO151320C (no) 1985-04-17
PL116532B1 (en) 1981-06-30
SE8603773L (sv) 1986-09-09
HU179793B (en) 1982-12-28
NL191707B (nl) 1995-12-01
GR64431B (en) 1980-03-21
PH15725A (en) 1983-03-18
BE872585A (fr) 1979-06-07
ES476755A1 (es) 1979-06-01
FR2415099B1 (ja) 1981-02-20
FR2415099A1 (fr) 1979-08-17
PT69068A (fr) 1979-02-01
NL191707C (nl) 1996-04-02
LU80786A1 (fr) 1979-09-07
PL118151B1 (en) 1981-09-30
CY1201A (en) 1983-12-31
GB2083458B (en) 1983-03-09
ES477782A1 (es) 1979-09-16
IE47798B1 (en) 1984-06-27
AR220574A1 (es) 1980-11-14
GB2012765A (en) 1979-08-01
ZA79219B (en) 1980-01-30
US4294828A (en) 1981-10-13
AU4337379A (en) 1979-07-26
MX5793E (es) 1984-07-19
SE7900380L (sv) 1979-07-21
US4401822A (en) 1983-08-30
FI790182A (fi) 1979-07-21
CH637927A5 (fr) 1983-08-31
BG31496A3 (en) 1982-01-15
YU5079A (en) 1983-06-30
DD141520A5 (de) 1980-05-07
AU528561B2 (en) 1983-05-05
RO76393A (ro) 1981-03-30
AT377977B (de) 1985-05-28
HK12184A (en) 1984-02-24
DE2901181A1 (de) 1979-07-26
IT7947706A0 (it) 1979-01-18
SE8603773D0 (sv) 1986-09-09
IT1164655B (it) 1987-04-15
DE2901181C2 (de) 1984-07-19
BG31497A3 (en) 1982-01-15
FI71126B (fi) 1986-08-14
GB2012765B (en) 1982-09-08

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