JPH0250906B2 - - Google Patents
Info
- Publication number
- JPH0250906B2 JPH0250906B2 JP56119373A JP11937381A JPH0250906B2 JP H0250906 B2 JPH0250906 B2 JP H0250906B2 JP 56119373 A JP56119373 A JP 56119373A JP 11937381 A JP11937381 A JP 11937381A JP H0250906 B2 JPH0250906 B2 JP H0250906B2
- Authority
- JP
- Japan
- Prior art keywords
- dihydro
- hydrogen
- oxepin
- oxodibenz
- acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- -1 5-tetrazolyl Chemical group 0.000 claims description 87
- 239000001257 hydrogen Substances 0.000 claims description 41
- 229910052739 hydrogen Inorganic materials 0.000 claims description 41
- 150000001875 compounds Chemical class 0.000 claims description 33
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 24
- 125000000217 alkyl group Chemical group 0.000 claims description 22
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims description 21
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 13
- 150000002431 hydrogen Chemical class 0.000 claims description 12
- 150000003839 salts Chemical class 0.000 claims description 10
- 125000003545 alkoxy group Chemical group 0.000 claims description 9
- 208000006673 asthma Diseases 0.000 claims description 9
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 9
- 125000004414 alkyl thio group Chemical group 0.000 claims description 8
- 239000008194 pharmaceutical composition Substances 0.000 claims description 6
- 125000004390 alkyl sulfonyl group Chemical group 0.000 claims description 5
- 125000004453 alkoxycarbonyl group Chemical group 0.000 claims description 3
- 125000002883 imidazolyl group Chemical group 0.000 claims description 3
- 239000003937 drug carrier Substances 0.000 claims description 2
- 125000000325 methylidene group Chemical group [H]C([H])=* 0.000 claims 6
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 5
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 2
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 2
- 125000002816 methylsulfanyl group Chemical group [H]C([H])([H])S[*] 0.000 claims 2
- 125000004170 methylsulfonyl group Chemical group [H]C([H])([H])S(*)(=O)=O 0.000 claims 2
- 150000002483 hydrogen compounds Chemical class 0.000 claims 1
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 description 99
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 96
- 239000000243 solution Substances 0.000 description 80
- 239000000047 product Substances 0.000 description 77
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 77
- RTZKZFJDLAIYFH-UHFFFAOYSA-N ether Substances CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 75
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 74
- 239000000203 mixture Substances 0.000 description 74
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 73
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 description 61
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 60
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 52
- FYSNRJHAOHDILO-UHFFFAOYSA-N thionyl chloride Chemical compound ClS(Cl)=O FYSNRJHAOHDILO-UHFFFAOYSA-N 0.000 description 50
- 239000007787 solid Substances 0.000 description 47
- 238000006243 chemical reaction Methods 0.000 description 43
- ATYBXHSAIOKLMG-UHFFFAOYSA-N oxepin Chemical compound O1C=CC=CC=C1 ATYBXHSAIOKLMG-UHFFFAOYSA-N 0.000 description 42
- 238000003756 stirring Methods 0.000 description 35
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 description 32
- 238000002844 melting Methods 0.000 description 32
- 230000008018 melting Effects 0.000 description 32
- 239000000284 extract Substances 0.000 description 30
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 28
- 239000002253 acid Substances 0.000 description 23
- 238000010992 reflux Methods 0.000 description 23
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 21
- CSNNHWWHGAXBCP-UHFFFAOYSA-L Magnesium sulfate Chemical compound [Mg+2].[O-][S+2]([O-])([O-])[O-] CSNNHWWHGAXBCP-UHFFFAOYSA-L 0.000 description 21
- 239000003921 oil Substances 0.000 description 21
- VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 description 20
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 19
- 239000002904 solvent Substances 0.000 description 19
- 239000000543 intermediate Substances 0.000 description 18
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 16
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 16
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 15
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 15
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 description 15
- 239000000741 silica gel Substances 0.000 description 15
- 229910002027 silica gel Inorganic materials 0.000 description 15
- NLXLAEXVIDQMFP-UHFFFAOYSA-N Ammonia chloride Chemical compound [NH4+].[Cl-] NLXLAEXVIDQMFP-UHFFFAOYSA-N 0.000 description 14
- 125000005599 alkyl carboxylate group Chemical group 0.000 description 14
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 13
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 12
- 150000002148 esters Chemical class 0.000 description 12
- VZGDMQKNWNREIO-UHFFFAOYSA-N tetrachloromethane Chemical compound ClC(Cl)(Cl)Cl VZGDMQKNWNREIO-UHFFFAOYSA-N 0.000 description 12
- QAEDZJGFFMLHHQ-UHFFFAOYSA-N trifluoroacetic anhydride Chemical compound FC(F)(F)C(=O)OC(=O)C(F)(F)F QAEDZJGFFMLHHQ-UHFFFAOYSA-N 0.000 description 12
- ZHNUHDYFZUAESO-UHFFFAOYSA-N Formamide Chemical compound NC=O ZHNUHDYFZUAESO-UHFFFAOYSA-N 0.000 description 11
- PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 description 11
- 125000005907 alkyl ester group Chemical group 0.000 description 11
- 238000000034 method Methods 0.000 description 11
- XQXPVVBIMDBYFF-UHFFFAOYSA-N 4-hydroxyphenylacetic acid Chemical compound OC(=O)CC1=CC=C(O)C=C1 XQXPVVBIMDBYFF-UHFFFAOYSA-N 0.000 description 10
- LSDPWZHWYPCBBB-UHFFFAOYSA-N Methanethiol Chemical compound SC LSDPWZHWYPCBBB-UHFFFAOYSA-N 0.000 description 10
- 229960000583 acetic acid Drugs 0.000 description 10
- 239000004480 active ingredient Substances 0.000 description 10
- 125000005431 alkyl carboxamide group Chemical group 0.000 description 10
- BWHMMNNQKKPAPP-UHFFFAOYSA-L potassium carbonate Chemical compound [K+].[K+].[O-]C([O-])=O BWHMMNNQKKPAPP-UHFFFAOYSA-L 0.000 description 10
- 229920006395 saturated elastomer Polymers 0.000 description 10
- PCLIMKBDDGJMGD-UHFFFAOYSA-N N-bromosuccinimide Chemical compound BrN1C(=O)CCC1=O PCLIMKBDDGJMGD-UHFFFAOYSA-N 0.000 description 9
- 229910021529 ammonia Inorganic materials 0.000 description 9
- BTANRVKWQNVYAZ-UHFFFAOYSA-N butan-2-ol Chemical compound CCC(C)O BTANRVKWQNVYAZ-UHFFFAOYSA-N 0.000 description 9
- 230000007062 hydrolysis Effects 0.000 description 9
- 238000006460 hydrolysis reaction Methods 0.000 description 9
- 150000003180 prostaglandins Chemical class 0.000 description 9
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 description 8
- LRHPLDYGYMQRHN-UHFFFAOYSA-N N-Butanol Chemical compound CCCCO LRHPLDYGYMQRHN-UHFFFAOYSA-N 0.000 description 8
- 235000011114 ammonium hydroxide Nutrition 0.000 description 8
- 239000003480 eluent Substances 0.000 description 8
- 238000001704 evaporation Methods 0.000 description 8
- 230000008020 evaporation Effects 0.000 description 8
- 239000007788 liquid Substances 0.000 description 8
- LPNYRYFBWFDTMA-UHFFFAOYSA-N potassium tert-butoxide Chemical compound [K+].CC(C)(C)[O-] LPNYRYFBWFDTMA-UHFFFAOYSA-N 0.000 description 8
- 238000001953 recrystallisation Methods 0.000 description 8
- RYHBNJHYFVUHQT-UHFFFAOYSA-N 1,4-Dioxane Chemical compound C1COCCO1 RYHBNJHYFVUHQT-UHFFFAOYSA-N 0.000 description 7
- NGNBDVOYPDDBFK-UHFFFAOYSA-N 2-[2,4-di(pentan-2-yl)phenoxy]acetyl chloride Chemical compound CCCC(C)C1=CC=C(OCC(Cl)=O)C(C(C)CCC)=C1 NGNBDVOYPDDBFK-UHFFFAOYSA-N 0.000 description 7
- VHUUQVKOLVNVRT-UHFFFAOYSA-N Ammonium hydroxide Chemical compound [NH4+].[OH-] VHUUQVKOLVNVRT-UHFFFAOYSA-N 0.000 description 7
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 7
- 150000001732 carboxylic acid derivatives Chemical class 0.000 description 7
- 239000012141 concentrate Substances 0.000 description 7
- 235000008504 concentrate Nutrition 0.000 description 7
- 238000000605 extraction Methods 0.000 description 7
- 125000004356 hydroxy functional group Chemical group O* 0.000 description 7
- 239000005457 ice water Substances 0.000 description 7
- 229910052943 magnesium sulfate Inorganic materials 0.000 description 7
- 235000019341 magnesium sulphate Nutrition 0.000 description 7
- 239000011541 reaction mixture Substances 0.000 description 7
- ONQCSXZSDOTCTG-UHFFFAOYSA-N 11-oxo-6h-benzo[c][1]benzoxepine-2-carbonyl chloride Chemical compound O1CC2=CC=CC=C2C(=O)C2=CC(C(=O)Cl)=CC=C21 ONQCSXZSDOTCTG-UHFFFAOYSA-N 0.000 description 6
- WNZQDUSMALZDQF-UHFFFAOYSA-N 2-benzofuran-1(3H)-one Chemical compound C1=CC=C2C(=O)OCC2=C1 WNZQDUSMALZDQF-UHFFFAOYSA-N 0.000 description 6
- DLFVBJFMPXGRIB-UHFFFAOYSA-N Acetamide Chemical compound CC(N)=O DLFVBJFMPXGRIB-UHFFFAOYSA-N 0.000 description 6
- ROSDSFDQCJNGOL-UHFFFAOYSA-N Dimethylamine Chemical compound CNC ROSDSFDQCJNGOL-UHFFFAOYSA-N 0.000 description 6
- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 description 6
- BAVYZALUXZFZLV-UHFFFAOYSA-N Methylamine Chemical compound NC BAVYZALUXZFZLV-UHFFFAOYSA-N 0.000 description 6
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 description 6
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 description 6
- PXIPVTKHYLBLMZ-UHFFFAOYSA-N Sodium azide Chemical compound [Na+].[N-]=[N+]=[N-] PXIPVTKHYLBLMZ-UHFFFAOYSA-N 0.000 description 6
- ZMANZCXQSJIPKH-UHFFFAOYSA-N Triethylamine Chemical compound CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 description 6
- 150000007513 acids Chemical class 0.000 description 6
- 235000019270 ammonium chloride Nutrition 0.000 description 6
- HQABUPZFAYXKJW-UHFFFAOYSA-N butan-1-amine Chemical compound CCCCN HQABUPZFAYXKJW-UHFFFAOYSA-N 0.000 description 6
- KXZJHVJKXJLBKO-UHFFFAOYSA-N chembl1408157 Chemical compound N=1C2=CC=CC=C2C(C(=O)O)=CC=1C1=CC=C(O)C=C1 KXZJHVJKXJLBKO-UHFFFAOYSA-N 0.000 description 6
- 238000000354 decomposition reaction Methods 0.000 description 6
- RAXXELZNTBOGNW-UHFFFAOYSA-N imidazole Natural products C1=CNC=N1 RAXXELZNTBOGNW-UHFFFAOYSA-N 0.000 description 6
- BDAGIHXWWSANSR-UHFFFAOYSA-N methanoic acid Natural products OC=O BDAGIHXWWSANSR-UHFFFAOYSA-N 0.000 description 6
- 239000012299 nitrogen atmosphere Substances 0.000 description 6
- 239000012044 organic layer Substances 0.000 description 6
- 229940094443 oxytocics prostaglandins Drugs 0.000 description 6
- 239000011780 sodium chloride Substances 0.000 description 6
- KZNICNPSHKQLFF-UHFFFAOYSA-N succinimide Chemical compound O=C1CCC(=O)N1 KZNICNPSHKQLFF-UHFFFAOYSA-N 0.000 description 6
- COXWXMDASYKDSK-UHFFFAOYSA-N 11-oxo-6h-benzo[c][1]benzoxepine-2-carboxylic acid Chemical compound O1CC2=CC=CC=C2C(=O)C2=CC(C(=O)O)=CC=C21 COXWXMDASYKDSK-UHFFFAOYSA-N 0.000 description 5
- 206010027654 Allergic conditions Diseases 0.000 description 5
- 150000003973 alkyl amines Chemical class 0.000 description 5
- 239000000908 ammonium hydroxide Substances 0.000 description 5
- 238000001816 cooling Methods 0.000 description 5
- 238000010790 dilution Methods 0.000 description 5
- 239000012895 dilution Substances 0.000 description 5
- 238000001914 filtration Methods 0.000 description 5
- 239000010410 layer Substances 0.000 description 5
- 229910052757 nitrogen Inorganic materials 0.000 description 5
- 229910000027 potassium carbonate Inorganic materials 0.000 description 5
- 239000002244 precipitate Substances 0.000 description 5
- 229910052938 sodium sulfate Inorganic materials 0.000 description 5
- 235000011152 sodium sulphate Nutrition 0.000 description 5
- 239000007858 starting material Substances 0.000 description 5
- RMVRSNDYEFQCLF-UHFFFAOYSA-N thiophenol Chemical class SC1=CC=CC=C1 RMVRSNDYEFQCLF-UHFFFAOYSA-N 0.000 description 5
- QTEZPBHGIAXMBA-UHFFFAOYSA-N 11-oxo-6h-benzo[c][1]benzoxepine-9-carbonyl chloride Chemical compound C1OC2=CC=CC=C2C(=O)C2=CC(C(=O)Cl)=CC=C21 QTEZPBHGIAXMBA-UHFFFAOYSA-N 0.000 description 4
- ALRHLSYJTWAHJZ-UHFFFAOYSA-N 3-hydroxypropionic acid Chemical compound OCCC(O)=O ALRHLSYJTWAHJZ-UHFFFAOYSA-N 0.000 description 4
- 239000004471 Glycine Substances 0.000 description 4
- UEEJHVSXFDXPFK-UHFFFAOYSA-N N-dimethylaminoethanol Chemical compound CN(C)CCO UEEJHVSXFDXPFK-UHFFFAOYSA-N 0.000 description 4
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 4
- 229910052783 alkali metal Inorganic materials 0.000 description 4
- 125000003282 alkyl amino group Chemical group 0.000 description 4
- 235000001014 amino acid Nutrition 0.000 description 4
- 229940024606 amino acid Drugs 0.000 description 4
- 150000001413 amino acids Chemical class 0.000 description 4
- DOBRDRYODQBAMW-UHFFFAOYSA-N copper(i) cyanide Chemical compound [Cu+].N#[C-] DOBRDRYODQBAMW-UHFFFAOYSA-N 0.000 description 4
- 238000002425 crystallisation Methods 0.000 description 4
- 230000008025 crystallization Effects 0.000 description 4
- 125000004093 cyano group Chemical group *C#N 0.000 description 4
- WYACBZDAHNBPPB-UHFFFAOYSA-N diethyl oxalate Chemical compound CCOC(=O)C(=O)OCC WYACBZDAHNBPPB-UHFFFAOYSA-N 0.000 description 4
- YWFQPQUOMOSCNV-UHFFFAOYSA-N methyl 11-chloro-6,11-dihydrobenzo[c][1]benzoxepine-2-carboxylate Chemical compound O1CC2=CC=CC=C2C(Cl)C2=CC(C(=O)OC)=CC=C21 YWFQPQUOMOSCNV-UHFFFAOYSA-N 0.000 description 4
- 150000002825 nitriles Chemical class 0.000 description 4
- YPFDHNVEDLHUCE-UHFFFAOYSA-N propane-1,3-diol Chemical compound OCCCO YPFDHNVEDLHUCE-UHFFFAOYSA-N 0.000 description 4
- 238000000746 purification Methods 0.000 description 4
- 239000000126 substance Substances 0.000 description 4
- 125000001424 substituent group Chemical group 0.000 description 4
- 239000000725 suspension Substances 0.000 description 4
- JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical compound CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 description 4
- XOJIZVJSMVEGGJ-UHFFFAOYSA-N 11-oxo-6h-benzo[c][1]benzoxepine-2-carboxamide Chemical compound O1CC2=CC=CC=C2C(=O)C2=CC(C(=O)N)=CC=C21 XOJIZVJSMVEGGJ-UHFFFAOYSA-N 0.000 description 3
- OSWFIVFLDKOXQC-UHFFFAOYSA-N 4-(3-methoxyphenyl)aniline Chemical compound COC1=CC=CC(C=2C=CC(N)=CC=2)=C1 OSWFIVFLDKOXQC-UHFFFAOYSA-N 0.000 description 3
- YUSHFLBKQQILNV-UHFFFAOYSA-N 6h-benzo[c][1]benzoxepin-11-one Chemical compound C1OC2=CC=CC=C2C(=O)C2=CC=CC=C21 YUSHFLBKQQILNV-UHFFFAOYSA-N 0.000 description 3
- 239000004342 Benzoyl peroxide Substances 0.000 description 3
- OMPJBNCRMGITSC-UHFFFAOYSA-N Benzoylperoxide Chemical compound C=1C=CC=CC=1C(=O)OOC(=O)C1=CC=CC=C1 OMPJBNCRMGITSC-UHFFFAOYSA-N 0.000 description 3
- QXNVGIXVLWOKEQ-UHFFFAOYSA-N Disodium Chemical class [Na][Na] QXNVGIXVLWOKEQ-UHFFFAOYSA-N 0.000 description 3
- KZSNJWFQEVHDMF-BYPYZUCNSA-N L-valine Chemical compound CC(C)[C@H](N)C(O)=O KZSNJWFQEVHDMF-BYPYZUCNSA-N 0.000 description 3
- 241001465754 Metazoa Species 0.000 description 3
- KZSNJWFQEVHDMF-UHFFFAOYSA-N Valine Natural products CC(C)C(N)C(O)=O KZSNJWFQEVHDMF-UHFFFAOYSA-N 0.000 description 3
- 150000001356 alkyl thiols Chemical class 0.000 description 3
- 150000001408 amides Chemical class 0.000 description 3
- 239000002585 base Substances 0.000 description 3
- 235000019400 benzoyl peroxide Nutrition 0.000 description 3
- 230000001851 biosynthetic effect Effects 0.000 description 3
- 230000037396 body weight Effects 0.000 description 3
- 238000009835 boiling Methods 0.000 description 3
- 150000003857 carboxamides Chemical class 0.000 description 3
- 238000007796 conventional method Methods 0.000 description 3
- WEHWNAOGRSTTBQ-UHFFFAOYSA-N dipropylamine Chemical compound CCCNCCC WEHWNAOGRSTTBQ-UHFFFAOYSA-N 0.000 description 3
- 238000001035 drying Methods 0.000 description 3
- 235000019253 formic acid Nutrition 0.000 description 3
- 238000010438 heat treatment Methods 0.000 description 3
- 239000004615 ingredient Substances 0.000 description 3
- VXWPONVCMVLXBW-UHFFFAOYSA-M magnesium;carbanide;iodide Chemical compound [CH3-].[Mg+2].[I-] VXWPONVCMVLXBW-UHFFFAOYSA-M 0.000 description 3
- NLBXYUUHUFAZDL-UHFFFAOYSA-N methyl 11-hydroxy-6,11-dihydrobenzo[c][1]benzoxepine-2-carboxylate Chemical compound O1CC2=CC=CC=C2C(O)C2=CC(C(=O)OC)=CC=C21 NLBXYUUHUFAZDL-UHFFFAOYSA-N 0.000 description 3
- 239000012074 organic phase Substances 0.000 description 3
- PMDLIAGAGUCEGN-UHFFFAOYSA-N oxepine-2-carboxylic acid Chemical compound OC(=O)C1=CC=CC=CO1 PMDLIAGAGUCEGN-UHFFFAOYSA-N 0.000 description 3
- 239000000843 powder Substances 0.000 description 3
- 239000012279 sodium borohydride Substances 0.000 description 3
- 229910000033 sodium borohydride Inorganic materials 0.000 description 3
- 229910000029 sodium carbonate Inorganic materials 0.000 description 3
- 159000000000 sodium salts Chemical class 0.000 description 3
- 229960002317 succinimide Drugs 0.000 description 3
- 239000003826 tablet Substances 0.000 description 3
- 239000004474 valine Substances 0.000 description 3
- PAAZPARNPHGIKF-UHFFFAOYSA-N 1,2-dibromoethane Chemical compound BrCCBr PAAZPARNPHGIKF-UHFFFAOYSA-N 0.000 description 2
- PAMIQIKDUOTOBW-UHFFFAOYSA-N 1-methylpiperidine Chemical compound CN1CCCCC1 PAMIQIKDUOTOBW-UHFFFAOYSA-N 0.000 description 2
- ZCGVFMLUPBKZFW-UHFFFAOYSA-N 11-ethylidene-6h-benzo[c][1]benzoxepine-2-carboxylic acid Chemical compound C1OC2=CC=C(C(O)=O)C=C2C(=CC)C2=CC=CC=C21 ZCGVFMLUPBKZFW-UHFFFAOYSA-N 0.000 description 2
- ZPZFHKGBBDMCNS-UHFFFAOYSA-N 11-imidazol-1-yl-6,11-dihydrobenzo[c][1]benzoxepine-2-carboxylic acid Chemical compound C12=CC(C(=O)O)=CC=C2OCC2=CC=CC=C2C1N1C=CN=C1 ZPZFHKGBBDMCNS-UHFFFAOYSA-N 0.000 description 2
- MACLQWMKAYWENX-UHFFFAOYSA-N 11-methoxy-6,11-dihydrobenzo[c][1]benzoxepine-2-carboxylic acid Chemical compound C1OC2=CC=C(C(O)=O)C=C2C(OC)C2=CC=CC=C21 MACLQWMKAYWENX-UHFFFAOYSA-N 0.000 description 2
- TVFVERWUXOCMOD-UHFFFAOYSA-N 11-methylidene-6h-benzo[c][1]benzoxepine-2-carboxylic acid Chemical compound O1CC2=CC=CC=C2C(=C)C2=CC(C(=O)O)=CC=C21 TVFVERWUXOCMOD-UHFFFAOYSA-N 0.000 description 2
- HLAGAYYFSNDXEV-UHFFFAOYSA-N 11-methylsulfanyl-6,11-dihydrobenzo[c][1]benzoxepine-2-carboxylic acid Chemical compound C1OC2=CC=C(C(O)=O)C=C2C(SC)C2=CC=CC=C21 HLAGAYYFSNDXEV-UHFFFAOYSA-N 0.000 description 2
- NVXUSWKPSJSHPQ-UHFFFAOYSA-N 11-methylsulfinyl-6,11-dihydrobenzo[c][1]benzoxepine-2-carboxylic acid Chemical compound C1OC2=CC=C(C(O)=O)C=C2C(S(=O)C)C2=CC=CC=C21 NVXUSWKPSJSHPQ-UHFFFAOYSA-N 0.000 description 2
- LILSQUHODHCIPJ-UHFFFAOYSA-N 11-methylsulfonyl-6,11-dihydrobenzo[c][1]benzoxepine-2-carboxylic acid Chemical compound C1OC2=CC=C(C(O)=O)C=C2C(S(=O)(=O)C)C2=CC=CC=C21 LILSQUHODHCIPJ-UHFFFAOYSA-N 0.000 description 2
- JPSANPLWEXUCLS-UHFFFAOYSA-N 11-oxo-6h-benzo[c][1]benzoxepine-2-carbonitrile Chemical compound C1OC2=CC=C(C#N)C=C2C(=O)C2=CC=CC=C21 JPSANPLWEXUCLS-UHFFFAOYSA-N 0.000 description 2
- VPPYPEUOGMCFNK-UHFFFAOYSA-N 11-phenylsulfanyl-6,11-dihydrobenzo[c][1]benzoxepine-2-carboxylic acid Chemical compound C12=CC(C(=O)O)=CC=C2OCC2=CC=CC=C2C1SC1=CC=CC=C1 VPPYPEUOGMCFNK-UHFFFAOYSA-N 0.000 description 2
- XHZQHUBAXVQHIU-UHFFFAOYSA-N 2-(2h-tetrazol-5-yl)-6h-benzo[c][1]benzoxepin-11-one Chemical compound C1=C2C(=O)C3=CC=CC=C3COC2=CC=C1C1=NN=NN1 XHZQHUBAXVQHIU-UHFFFAOYSA-N 0.000 description 2
- LFDYIGJPTJKEQG-UHFFFAOYSA-N 2-[(4-bromophenoxy)methyl]benzoic acid Chemical compound OC(=O)C1=CC=CC=C1COC1=CC=C(Br)C=C1 LFDYIGJPTJKEQG-UHFFFAOYSA-N 0.000 description 2
- BCYWXPITXHFIQM-UHFFFAOYSA-N 2-[[4-(carboxymethyl)phenoxy]methyl]benzoic acid Chemical compound C1=CC(CC(=O)O)=CC=C1OCC1=CC=CC=C1C(O)=O BCYWXPITXHFIQM-UHFFFAOYSA-N 0.000 description 2
- HNYWNENWCYINCA-UHFFFAOYSA-N 2-phenyl-2-phenylmethoxypropanedioic acid Chemical compound C=1C=CC=CC=1C(C(=O)O)(C(O)=O)OCC1=CC=CC=C1 HNYWNENWCYINCA-UHFFFAOYSA-N 0.000 description 2
- WHBMMWSBFZVSSR-UHFFFAOYSA-N 3-hydroxybutyric acid Chemical compound CC(O)CC(O)=O WHBMMWSBFZVSSR-UHFFFAOYSA-N 0.000 description 2
- YMTRVMXXEIEMLP-UHFFFAOYSA-N 3-methyl-1,3-thiazolidin-2-imine Chemical compound CN1CCSC1=N YMTRVMXXEIEMLP-UHFFFAOYSA-N 0.000 description 2
- VLJSLTNSFSOYQR-UHFFFAOYSA-N 3-propan-2-ylphenol Chemical compound CC(C)C1=CC=CC(O)=C1 VLJSLTNSFSOYQR-UHFFFAOYSA-N 0.000 description 2
- RKZFJQWTTKICCN-UHFFFAOYSA-N 4-bromo-2-[(3-propan-2-ylphenoxy)methyl]benzoic acid Chemical compound CC(C)C1=CC=CC(OCC=2C(=CC=C(Br)C=2)C(O)=O)=C1 RKZFJQWTTKICCN-UHFFFAOYSA-N 0.000 description 2
- GZFGOTFRPZRKDS-UHFFFAOYSA-N 4-bromophenol Chemical compound OC1=CC=C(Br)C=C1 GZFGOTFRPZRKDS-UHFFFAOYSA-N 0.000 description 2
- MBVFRSJFKMJRHA-UHFFFAOYSA-N 4-fluoro-1-benzofuran-7-carbaldehyde Chemical compound FC1=CC=C(C=O)C2=C1C=CO2 MBVFRSJFKMJRHA-UHFFFAOYSA-N 0.000 description 2
- SEENCYZQHCUTSB-UHFFFAOYSA-N 5-bromo-2-methylbenzoic acid Chemical compound CC1=CC=C(Br)C=C1C(O)=O SEENCYZQHCUTSB-UHFFFAOYSA-N 0.000 description 2
- NKCSCEXZJIJKME-UHFFFAOYSA-N 5-methyl-2-(phenoxymethyl)benzoic acid Chemical compound OC(=O)C1=CC(C)=CC=C1COC1=CC=CC=C1 NKCSCEXZJIJKME-UHFFFAOYSA-N 0.000 description 2
- XOFXYPKWXNZBDL-UHFFFAOYSA-N 6,11-dihydro-2,3-methylenedioxy-11-oxodibenz[b,e]oxepin-9-carboxylic acid Chemical compound C1=C2C(=O)C3=CC(C(=O)O)=CC=C3COC2=CC2=C1OCO2 XOFXYPKWXNZBDL-UHFFFAOYSA-N 0.000 description 2
- JKWBVEIJRJVEMW-UHFFFAOYSA-N 6,11-dihydrobenzo[c][1]benzoxepine-2-carboxylic acid Chemical compound O1CC2=CC=CC=C2CC2=CC(C(=O)O)=CC=C21 JKWBVEIJRJVEMW-UHFFFAOYSA-N 0.000 description 2
- YNXGZAZFHFMWPY-UHFFFAOYSA-N 6-methyl-3h-2-benzofuran-1-one Chemical compound CC1=CC=C2COC(=O)C2=C1 YNXGZAZFHFMWPY-UHFFFAOYSA-N 0.000 description 2
- KKYMQROXVIAEOT-UHFFFAOYSA-N 9-bromo-6,11-dihydro-2,3-methylenedioxy-11-oxodibenz[b,e]oxepin Chemical compound C1=C2C(=O)C3=CC(Br)=CC=C3COC2=CC2=C1OCO2 KKYMQROXVIAEOT-UHFFFAOYSA-N 0.000 description 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- 229910015900 BF3 Inorganic materials 0.000 description 2
- CPELXLSAUQHCOX-UHFFFAOYSA-M Bromide Chemical compound [Br-] CPELXLSAUQHCOX-UHFFFAOYSA-M 0.000 description 2
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 description 2
- XDTMQSROBMDMFD-UHFFFAOYSA-N Cyclohexane Chemical compound C1CCCCC1 XDTMQSROBMDMFD-UHFFFAOYSA-N 0.000 description 2
- ZAFNJMIOTHYJRJ-UHFFFAOYSA-N Diisopropyl ether Chemical compound CC(C)OC(C)C ZAFNJMIOTHYJRJ-UHFFFAOYSA-N 0.000 description 2
- QUSNBJAOOMFDIB-UHFFFAOYSA-N Ethylamine Chemical compound CCN QUSNBJAOOMFDIB-UHFFFAOYSA-N 0.000 description 2
- AEMRFAOFKBGASW-UHFFFAOYSA-N Glycolic acid Chemical compound OCC(O)=O AEMRFAOFKBGASW-UHFFFAOYSA-N 0.000 description 2
- QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 description 2
- YNAVUWVOSKDBBP-UHFFFAOYSA-N Morpholine Chemical compound C1COCCN1 YNAVUWVOSKDBBP-UHFFFAOYSA-N 0.000 description 2
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 description 2
- GLUUGHFHXGJENI-UHFFFAOYSA-N Piperazine Chemical compound C1CNCCN1 GLUUGHFHXGJENI-UHFFFAOYSA-N 0.000 description 2
- NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical compound C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 description 2
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 description 2
- 239000007868 Raney catalyst Substances 0.000 description 2
- 229910000564 Raney nickel Inorganic materials 0.000 description 2
- NPXOKRUENSOPAO-UHFFFAOYSA-N Raney nickel Chemical compound [Al].[Ni] NPXOKRUENSOPAO-UHFFFAOYSA-N 0.000 description 2
- LUSZGTFNYDARNI-UHFFFAOYSA-N Sesamol Chemical compound OC1=CC=C2OCOC2=C1 LUSZGTFNYDARNI-UHFFFAOYSA-N 0.000 description 2
- HEDRZPFGACZZDS-MICDWDOJSA-N Trichloro(2H)methane Chemical compound [2H]C(Cl)(Cl)Cl HEDRZPFGACZZDS-MICDWDOJSA-N 0.000 description 2
- RDCOMWQFSWWPJG-UHFFFAOYSA-N acetyl acetate;formic acid Chemical compound OC=O.CC(=O)OC(C)=O RDCOMWQFSWWPJG-UHFFFAOYSA-N 0.000 description 2
- 235000004279 alanine Nutrition 0.000 description 2
- 125000001118 alkylidene group Chemical group 0.000 description 2
- YNQLUTRBYVCPMQ-UHFFFAOYSA-N alpha-methyl toluene Natural products CCC1=CC=CC=C1 YNQLUTRBYVCPMQ-UHFFFAOYSA-N 0.000 description 2
- VSCWAEJMTAWNJL-UHFFFAOYSA-K aluminium trichloride Chemical compound Cl[Al](Cl)Cl VSCWAEJMTAWNJL-UHFFFAOYSA-K 0.000 description 2
- DFNYGALUNNFWKJ-UHFFFAOYSA-N aminoacetonitrile Chemical compound NCC#N DFNYGALUNNFWKJ-UHFFFAOYSA-N 0.000 description 2
- 239000008346 aqueous phase Substances 0.000 description 2
- 239000007864 aqueous solution Substances 0.000 description 2
- NVQOFWZLYDVFMU-UHFFFAOYSA-N azane;oxolane Chemical class N.C1CCOC1 NVQOFWZLYDVFMU-UHFFFAOYSA-N 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- WTEOIRVLGSZEPR-UHFFFAOYSA-N boron trifluoride Chemical compound FB(F)F WTEOIRVLGSZEPR-UHFFFAOYSA-N 0.000 description 2
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 description 2
- 229910052794 bromium Inorganic materials 0.000 description 2
- WERYXYBDKMZEQL-UHFFFAOYSA-N butane-1,4-diol Chemical compound OCCCCO WERYXYBDKMZEQL-UHFFFAOYSA-N 0.000 description 2
- 239000002775 capsule Substances 0.000 description 2
- 239000000969 carrier Substances 0.000 description 2
- 239000003638 chemical reducing agent Substances 0.000 description 2
- 125000001309 chloro group Chemical group Cl* 0.000 description 2
- 239000013078 crystal Substances 0.000 description 2
- DMEGYFMYUHOHGS-UHFFFAOYSA-N cycloheptane Chemical compound C1CCCCCC1 DMEGYFMYUHOHGS-UHFFFAOYSA-N 0.000 description 2
- JQVDAXLFBXTEQA-UHFFFAOYSA-N dibutylamine Chemical compound CCCCNCCCC JQVDAXLFBXTEQA-UHFFFAOYSA-N 0.000 description 2
- HPNMFZURTQLUMO-UHFFFAOYSA-N diethylamine Chemical compound CCNCC HPNMFZURTQLUMO-UHFFFAOYSA-N 0.000 description 2
- XBDQKXXYIPTUBI-UHFFFAOYSA-N dimethylselenoniopropionate Natural products CCC(O)=O XBDQKXXYIPTUBI-UHFFFAOYSA-N 0.000 description 2
- PXJJSXABGXMUSU-UHFFFAOYSA-N disulfur dichloride Chemical compound ClSSCl PXJJSXABGXMUSU-UHFFFAOYSA-N 0.000 description 2
- 239000002552 dosage form Substances 0.000 description 2
- 238000000921 elemental analysis Methods 0.000 description 2
- 239000000839 emulsion Substances 0.000 description 2
- 125000004185 ester group Chemical group 0.000 description 2
- JHYNXXDQQHTCHJ-UHFFFAOYSA-M ethyl(triphenyl)phosphanium;bromide Chemical compound [Br-].C=1C=CC=CC=1[P+](C=1C=CC=CC=1)(CC)C1=CC=CC=C1 JHYNXXDQQHTCHJ-UHFFFAOYSA-M 0.000 description 2
- 239000012467 final product Substances 0.000 description 2
- 239000012362 glacial acetic acid Substances 0.000 description 2
- 239000008187 granular material Substances 0.000 description 2
- 238000011065 in-situ storage Methods 0.000 description 2
- 239000003112 inhibitor Substances 0.000 description 2
- 238000001990 intravenous administration Methods 0.000 description 2
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 2
- JJWLVOIRVHMVIS-UHFFFAOYSA-N isopropylamine Chemical compound CC(C)N JJWLVOIRVHMVIS-UHFFFAOYSA-N 0.000 description 2
- UBJFKNSINUCEAL-UHFFFAOYSA-N lithium;2-methylpropane Chemical compound [Li+].C[C-](C)C UBJFKNSINUCEAL-UHFFFAOYSA-N 0.000 description 2
- 239000000314 lubricant Substances 0.000 description 2
- GDTMLSFCWTZUCT-UHFFFAOYSA-N methyl 11-formamido-6,11-dihydrobenzo[c][1]benzoxepine-2-carboxylate Chemical compound O1CC2=CC=CC=C2C(NC=O)C2=CC(C(=O)OC)=CC=C21 GDTMLSFCWTZUCT-UHFFFAOYSA-N 0.000 description 2
- YRYBXFKCAOYLCK-UHFFFAOYSA-N methyl 11-hydroxy-11-methyl-6h-benzo[c][1]benzoxepine-2-carboxylate Chemical compound O1CC2=CC=CC=C2C(C)(O)C2=CC(C(=O)OC)=CC=C21 YRYBXFKCAOYLCK-UHFFFAOYSA-N 0.000 description 2
- BCKOLYPIPZRJEL-UHFFFAOYSA-N methyl 11-oxo-6h-benzo[c][1]benzoxepine-2-carboxylate Chemical compound O1CC2=CC=CC=C2C(=O)C2=CC(C(=O)OC)=CC=C21 BCKOLYPIPZRJEL-UHFFFAOYSA-N 0.000 description 2
- SJKZSVBBEIEGNJ-UHFFFAOYSA-N methyl 11-oxo-6h-benzo[c][1]benzoxepine-9-carboxylate Chemical compound C1OC2=CC=CC=C2C(=O)C2=CC(C(=O)OC)=CC=C21 SJKZSVBBEIEGNJ-UHFFFAOYSA-N 0.000 description 2
- QKASDIPENBEWBU-UHFFFAOYSA-N methyl 2-(bromomethyl)benzoate Chemical compound COC(=O)C1=CC=CC=C1CBr QKASDIPENBEWBU-UHFFFAOYSA-N 0.000 description 2
- KICYBCDMALTFPX-UHFFFAOYSA-N methyl 2-[(4-bromophenoxy)methyl]benzoate Chemical compound COC(=O)C1=CC=CC=C1COC1=CC=C(Br)C=C1 KICYBCDMALTFPX-UHFFFAOYSA-N 0.000 description 2
- 150000004702 methyl esters Chemical class 0.000 description 2
- 238000000465 moulding Methods 0.000 description 2
- 230000007935 neutral effect Effects 0.000 description 2
- ZWLPBLYKEWSWPD-UHFFFAOYSA-N o-toluic acid Chemical compound CC1=CC=CC=C1C(O)=O ZWLPBLYKEWSWPD-UHFFFAOYSA-N 0.000 description 2
- 239000003960 organic solvent Substances 0.000 description 2
- 150000002920 oxepines Chemical class 0.000 description 2
- 230000001575 pathological effect Effects 0.000 description 2
- 239000003208 petroleum Substances 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- BDERNNFJNOPAEC-UHFFFAOYSA-N propan-1-ol Chemical compound CCCO BDERNNFJNOPAEC-UHFFFAOYSA-N 0.000 description 2
- WGYKZJWCGVVSQN-UHFFFAOYSA-N propylamine Chemical compound CCCN WGYKZJWCGVVSQN-UHFFFAOYSA-N 0.000 description 2
- YIBNHAJFJUQSRA-YNNPMVKQSA-N prostaglandin H2 Chemical compound C1[C@@H]2OO[C@H]1[C@H](/C=C/[C@@H](O)CCCCC)[C@H]2C\C=C/CCCC(O)=O YIBNHAJFJUQSRA-YNNPMVKQSA-N 0.000 description 2
- 238000007363 ring formation reaction Methods 0.000 description 2
- FSYKKLYZXJSNPZ-UHFFFAOYSA-N sarcosine Chemical compound C[NH2+]CC([O-])=O FSYKKLYZXJSNPZ-UHFFFAOYSA-N 0.000 description 2
- 238000000926 separation method Methods 0.000 description 2
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 2
- 235000017557 sodium bicarbonate Nutrition 0.000 description 2
- MNWBNISUBARLIT-UHFFFAOYSA-N sodium cyanide Chemical class [Na+].N#[C-] MNWBNISUBARLIT-UHFFFAOYSA-N 0.000 description 2
- NESLWCLHZZISNB-UHFFFAOYSA-M sodium phenolate Chemical class [Na+].[O-]C1=CC=CC=C1 NESLWCLHZZISNB-UHFFFAOYSA-M 0.000 description 2
- LYPGDCWPTHTUDO-UHFFFAOYSA-M sodium;methanesulfinate Chemical compound [Na+].CS([O-])=O LYPGDCWPTHTUDO-UHFFFAOYSA-M 0.000 description 2
- 208000010110 spontaneous platelet aggregation Diseases 0.000 description 2
- 230000001225 therapeutic effect Effects 0.000 description 2
- 238000004809 thin layer chromatography Methods 0.000 description 2
- GETQZCLCWQTVFV-UHFFFAOYSA-N trimethylamine Chemical compound CN(C)C GETQZCLCWQTVFV-UHFFFAOYSA-N 0.000 description 2
- 238000001665 trituration Methods 0.000 description 2
- 239000003039 volatile agent Substances 0.000 description 2
- 238000010792 warming Methods 0.000 description 2
- 238000005406 washing Methods 0.000 description 2
- IHCWFFPGAOZJBF-IUCAKERBSA-N (2s,3s)-2-(butylamino)-3-methylpentanoic acid Chemical compound CCCCN[C@H](C(O)=O)[C@@H](C)CC IHCWFFPGAOZJBF-IUCAKERBSA-N 0.000 description 1
- WSLDOOZREJYCGB-UHFFFAOYSA-N 1,2-Dichloroethane Chemical compound ClCCCl WSLDOOZREJYCGB-UHFFFAOYSA-N 0.000 description 1
- RNHDAKUGFHSZEV-UHFFFAOYSA-N 1,4-dioxane;hydrate Chemical compound O.C1COCCO1 RNHDAKUGFHSZEV-UHFFFAOYSA-N 0.000 description 1
- PVOAHINGSUIXLS-UHFFFAOYSA-N 1-Methylpiperazine Chemical compound CN1CCNCC1 PVOAHINGSUIXLS-UHFFFAOYSA-N 0.000 description 1
- IKHRTJOWMZVGHW-UHFFFAOYSA-N 11-amino-6,11-dihydrobenzo[c][1]benzoxepine-2-carboxylic acid;hydrochloride Chemical compound Cl.C1OC2=CC=C(C(O)=O)C=C2C(N)C2=CC=CC=C21 IKHRTJOWMZVGHW-UHFFFAOYSA-N 0.000 description 1
- LZGZDRSZOKQIHN-UHFFFAOYSA-N 11-chloro-6,11-dihydrobenzo[c][1]benzoxepine Chemical compound C1OC2=CC=CC=C2C(Cl)C2=CC=CC=C21 LZGZDRSZOKQIHN-UHFFFAOYSA-N 0.000 description 1
- BBMDMLTWXADRCO-UHFFFAOYSA-N 11-ethylidene-6h-benzo[c][1]benzoxepine-2-carbonitrile Chemical compound C1OC2=CC=C(C#N)C=C2C(=CC)C2=CC=CC=C21 BBMDMLTWXADRCO-UHFFFAOYSA-N 0.000 description 1
- WCBVLQCFUHZJPU-UHFFFAOYSA-N 11-hydroxy-11-methyl-6h-benzo[c][1]benzoxepine-2-carboxylic acid Chemical compound C1OC2=CC=C(C(O)=O)C=C2C(C)(O)C2=CC=CC=C21 WCBVLQCFUHZJPU-UHFFFAOYSA-N 0.000 description 1
- PDWWEFKWQZLCSG-UHFFFAOYSA-N 11-hydroxy-6,11-dihydrobenzo[c][1]benzoxepine-2-carboxylic acid Chemical compound C1OC2=CC=C(C(O)=O)C=C2C(O)C2=CC=CC=C21 PDWWEFKWQZLCSG-UHFFFAOYSA-N 0.000 description 1
- MZGMBFFPBWIMPT-UHFFFAOYSA-N 11-methyl-6,11-dihydrobenzo[c][1]benzoxepine-2-carboxylic acid Chemical compound C1OC2=CC=C(C(O)=O)C=C2C(C)C2=CC=CC=C21 MZGMBFFPBWIMPT-UHFFFAOYSA-N 0.000 description 1
- KIQQIAZTDAWGAO-UHFFFAOYSA-N 11-methylsulfonyl-6,11-dihydrobenzo[c][1]benzoxepine Chemical compound C1OC2=CC=CC=C2C(S(=O)(=O)C)C2=CC=CC=C21 KIQQIAZTDAWGAO-UHFFFAOYSA-N 0.000 description 1
- JUQHNRBLTCAMKB-UHFFFAOYSA-N 11-oxo-3-propan-2-yl-6h-benzo[c][1]benzoxepine-9-carboxylic acid Chemical compound O1CC2=CC=C(C(O)=O)C=C2C(=O)C2=CC=C(C(C)C)C=C12 JUQHNRBLTCAMKB-UHFFFAOYSA-N 0.000 description 1
- KQFRFACQQZLGRH-UHFFFAOYSA-N 11-oxo-6h-benzo[c][1]benzoxepine-2-carbaldehyde Chemical compound O1CC2=CC=CC=C2C(=O)C2=CC(C=O)=CC=C21 KQFRFACQQZLGRH-UHFFFAOYSA-N 0.000 description 1
- LWMPQIRXDKLZDB-UHFFFAOYSA-N 11-oxo-6h-benzo[c][1]benzoxepine-9-carbonitrile Chemical compound C1OC2=CC=CC=C2C(=O)C2=CC(C#N)=CC=C21 LWMPQIRXDKLZDB-UHFFFAOYSA-N 0.000 description 1
- WBYLROLGSFNMNB-UHFFFAOYSA-N 11-oxo-6h-benzo[c][1]benzoxepine-9-carboxamide Chemical compound C1OC2=CC=CC=C2C(=O)C2=CC(C(=O)N)=CC=C21 WBYLROLGSFNMNB-UHFFFAOYSA-N 0.000 description 1
- VZOPCLFQIQYLQO-UHFFFAOYSA-N 11-oxo-6h-benzo[c][1]benzoxepine-9-carboxylic acid Chemical compound C1OC2=CC=CC=C2C(=O)C2=CC(C(=O)O)=CC=C21 VZOPCLFQIQYLQO-UHFFFAOYSA-N 0.000 description 1
- WFKRSEGYPZMXPU-UHFFFAOYSA-N 2-(1,3-benzodioxol-5-yloxymethyl)-4-bromobenzoic acid Chemical compound OC(=O)C1=CC=C(Br)C=C1COC1=CC=C(OCO2)C2=C1 WFKRSEGYPZMXPU-UHFFFAOYSA-N 0.000 description 1
- UHUFXANNLAVUGB-UHFFFAOYSA-N 2-(11-oxo-6h-benzo[c][1]benzoxepin-2-yl)acetamide Chemical compound O1CC2=CC=CC=C2C(=O)C2=CC(CC(=O)N)=CC=C21 UHUFXANNLAVUGB-UHFFFAOYSA-N 0.000 description 1
- IZRPEBKKPRBUNN-UHFFFAOYSA-N 2-(11-oxo-6h-benzo[c][1]benzoxepin-2-yl)acetic acid;2,2,2-trifluoroacetic acid Chemical class OC(=O)C(F)(F)F.O1CC2=CC=CC=C2C(=O)C2=CC(CC(=O)O)=CC=C21 IZRPEBKKPRBUNN-UHFFFAOYSA-N 0.000 description 1
- OWOZLTVSQSXUTQ-UHFFFAOYSA-N 2-(11-oxo-6h-benzo[c][1]benzoxepin-9-yl)acetic acid Chemical compound C1OC2=CC=CC=C2C(=O)C2=CC(CC(=O)O)=CC=C21 OWOZLTVSQSXUTQ-UHFFFAOYSA-N 0.000 description 1
- VHIXBNRTKHCWFE-UHFFFAOYSA-N 2-(2h-tetrazol-5-yl)-6,11-dihydrobenzo[c][1]benzoxepin-11-ol Chemical compound C1=C2C(O)C3=CC=CC=C3COC2=CC=C1C1=NN=NN1 VHIXBNRTKHCWFE-UHFFFAOYSA-N 0.000 description 1
- JGIYFJISUOJGHD-UHFFFAOYSA-N 2-(dimethylamino)ethyl 11-oxo-6h-benzo[c][1]benzoxepine-9-carboxylate Chemical compound C1OC2=CC=CC=C2C(=O)C2=CC(C(=O)OCCN(C)C)=CC=C21 JGIYFJISUOJGHD-UHFFFAOYSA-N 0.000 description 1
- YKNORODREYVARM-UHFFFAOYSA-N 2-(phenoxymethyl)benzoic acid Chemical compound OC(=O)C1=CC=CC=C1COC1=CC=CC=C1 YKNORODREYVARM-UHFFFAOYSA-N 0.000 description 1
- SCGVCJYNNVRXRT-UHFFFAOYSA-N 2-amino-2-(11-oxo-6h-benzo[c][1]benzoxepin-2-yl)acetamide Chemical compound O1CC2=CC=CC=C2C(=O)C2=CC(C(C(N)=O)N)=CC=C21 SCGVCJYNNVRXRT-UHFFFAOYSA-N 0.000 description 1
- UWDLPLWBIHHXQN-UHFFFAOYSA-N 2-amino-2-(11-oxo-6h-benzo[c][1]benzoxepin-2-yl)acetonitrile Chemical compound O1CC2=CC=CC=C2C(=O)C2=CC(C(C#N)N)=CC=C21 UWDLPLWBIHHXQN-UHFFFAOYSA-N 0.000 description 1
- BFSVOASYOCHEOV-UHFFFAOYSA-N 2-diethylaminoethanol Chemical compound CCN(CC)CCO BFSVOASYOCHEOV-UHFFFAOYSA-N 0.000 description 1
- AVZKINFJMJGOEE-UHFFFAOYSA-N 3-(11-oxo-6h-benzo[c][1]benzoxepine-2-carbonyl)oxypropanoic acid Chemical compound O1CC2=CC=CC=C2C(=O)C2=CC(C(=O)OCCC(=O)O)=CC=C21 AVZKINFJMJGOEE-UHFFFAOYSA-N 0.000 description 1
- PYSGFFTXMUWEOT-UHFFFAOYSA-N 3-(dimethylamino)propan-1-ol Chemical compound CN(C)CCCO PYSGFFTXMUWEOT-UHFFFAOYSA-N 0.000 description 1
- NHQDETIJWKXCTC-UHFFFAOYSA-N 3-chloroperbenzoic acid Chemical compound OOC(=O)C1=CC=CC(Cl)=C1 NHQDETIJWKXCTC-UHFFFAOYSA-N 0.000 description 1
- COUKOZBIKJYAOA-UHFFFAOYSA-N 4-(11-oxo-6h-benzo[c][1]benzoxepin-2-yl)-1,2,5-thiadiazol-3-one Chemical compound OC1=NSN=C1C1=CC=C(OCC=2C(=CC=CC=2)C2=O)C2=C1 COUKOZBIKJYAOA-UHFFFAOYSA-N 0.000 description 1
- KHYKXDSWXWVQTA-UHFFFAOYSA-N 4-(diethylamino)butan-1-ol Chemical compound CCN(CC)CCCCO KHYKXDSWXWVQTA-UHFFFAOYSA-N 0.000 description 1
- USEUIZFNMZIVML-UHFFFAOYSA-N 6,11-dihydrobenzo[c][1]benzoxepin-11-ol Chemical compound C1OC2=CC=CC=C2C(O)C2=CC=CC=C21 USEUIZFNMZIVML-UHFFFAOYSA-N 0.000 description 1
- VGGVWNCHZPLXAY-UHFFFAOYSA-N 9-(2h-tetrazol-5-yl)-6h-benzo[c][1]benzoxepin-11-one Chemical compound C=1C=C2COC3=CC=CC=C3C(=O)C2=CC=1C1=NN=NN1 VGGVWNCHZPLXAY-UHFFFAOYSA-N 0.000 description 1
- DEUYXNHREVMQEH-UHFFFAOYSA-N 9-(bromomethyl)-6h-benzo[c][1]benzoxepin-11-one Chemical compound C1OC2=CC=CC=C2C(=O)C2=CC(CBr)=CC=C21 DEUYXNHREVMQEH-UHFFFAOYSA-N 0.000 description 1
- SPZFSWXSSYCUSA-UHFFFAOYSA-N 9-bromo-3-propan-2-yl-6h-benzo[c][1]benzoxepin-11-one Chemical compound O1CC2=CC=C(Br)C=C2C(=O)C2=CC=C(C(C)C)C=C12 SPZFSWXSSYCUSA-UHFFFAOYSA-N 0.000 description 1
- GYPMYTOZCFVBIC-UHFFFAOYSA-N 9-methyl-6h-benzo[c][1]benzoxepin-11-one Chemical compound C1OC2=CC=CC=C2C(=O)C2=CC(C)=CC=C21 GYPMYTOZCFVBIC-UHFFFAOYSA-N 0.000 description 1
- 206010002383 Angina Pectoris Diseases 0.000 description 1
- 201000001320 Atherosclerosis Diseases 0.000 description 1
- BVKZGUZCCUSVTD-UHFFFAOYSA-M Bicarbonate Chemical compound OC([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-M 0.000 description 1
- LSNNMFCWUKXFEE-UHFFFAOYSA-M Bisulfite Chemical group OS([O-])=O LSNNMFCWUKXFEE-UHFFFAOYSA-M 0.000 description 1
- ZOXJGFHDIHLPTG-UHFFFAOYSA-N Boron Chemical compound [B] ZOXJGFHDIHLPTG-UHFFFAOYSA-N 0.000 description 1
- KZMGYPLQYOPHEL-UHFFFAOYSA-N Boron trifluoride etherate Chemical compound FB(F)F.CCOCC KZMGYPLQYOPHEL-UHFFFAOYSA-N 0.000 description 1
- LULGYFLCQWFPFB-UHFFFAOYSA-N CN1CCSC1=NC=O Chemical compound CN1CCSC1=NC=O LULGYFLCQWFPFB-UHFFFAOYSA-N 0.000 description 1
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 1
- 206010010904 Convulsion Diseases 0.000 description 1
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 description 1
- 206010012735 Diarrhoea Diseases 0.000 description 1
- 239000007818 Grignard reagent Substances 0.000 description 1
- 206010020772 Hypertension Diseases 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 1
- AGPKZVBTJJNPAG-WHFBIAKZSA-N L-isoleucine Chemical compound CC[C@H](C)[C@H](N)C(O)=O AGPKZVBTJJNPAG-WHFBIAKZSA-N 0.000 description 1
- ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 description 1
- ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 description 1
- 208000019693 Lung disease Diseases 0.000 description 1
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 1
- 208000037093 Menstruation Disturbances Diseases 0.000 description 1
- 108010077895 Sarcosine Proteins 0.000 description 1
- FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 description 1
- GSEJCLTVZPLZKY-UHFFFAOYSA-N Triethanolamine Chemical compound OCCN(CCO)CCO GSEJCLTVZPLZKY-UHFFFAOYSA-N 0.000 description 1
- KWEWNAXCUWXEHQ-UHFFFAOYSA-M [I-].CCC[Mg+] Chemical compound [I-].CCC[Mg+] KWEWNAXCUWXEHQ-UHFFFAOYSA-M 0.000 description 1
- FNYDBZNYZMEWJI-UHFFFAOYSA-N [K].SC Chemical compound [K].SC FNYDBZNYZMEWJI-UHFFFAOYSA-N 0.000 description 1
- ORWKVZNEPHTCQE-UHFFFAOYSA-N acetic formic anhydride Chemical compound CC(=O)OC=O ORWKVZNEPHTCQE-UHFFFAOYSA-N 0.000 description 1
- 238000005903 acid hydrolysis reaction Methods 0.000 description 1
- 230000002378 acidificating effect Effects 0.000 description 1
- 230000001476 alcoholic effect Effects 0.000 description 1
- 150000001299 aldehydes Chemical class 0.000 description 1
- 125000005037 alkyl phenyl group Chemical group 0.000 description 1
- 125000004644 alkyl sulfinyl group Chemical group 0.000 description 1
- 125000004422 alkyl sulphonamide group Chemical group 0.000 description 1
- 201000009961 allergic asthma Diseases 0.000 description 1
- 229910045601 alloy Inorganic materials 0.000 description 1
- 239000000956 alloy Substances 0.000 description 1
- 150000003863 ammonium salts Chemical class 0.000 description 1
- 150000008064 anhydrides Chemical class 0.000 description 1
- 230000008485 antagonism Effects 0.000 description 1
- 239000002260 anti-inflammatory agent Substances 0.000 description 1
- 229940121363 anti-inflammatory agent Drugs 0.000 description 1
- 239000011260 aqueous acid Substances 0.000 description 1
- 239000006286 aqueous extract Substances 0.000 description 1
- 150000001504 aryl thiols Chemical class 0.000 description 1
- VWDMLXCZMRJEMI-UHFFFAOYSA-N benzo[c][1]benzoxepin-11-ol Chemical compound OC1=C2C=CC=CC2=COC2=CC=CC=C12 VWDMLXCZMRJEMI-UHFFFAOYSA-N 0.000 description 1
- WPYMKLBDIGXBTP-UHFFFAOYSA-M benzoate Chemical compound [O-]C(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-M 0.000 description 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 description 1
- WTEPWWCRWNCUNA-UHFFFAOYSA-M benzyl(triphenyl)phosphanium;bromide Chemical class [Br-].C=1C=CC=CC=1[P+](C=1C=CC=CC=1)(C=1C=CC=CC=1)CC1=CC=CC=C1 WTEPWWCRWNCUNA-UHFFFAOYSA-M 0.000 description 1
- 239000011230 binding agent Substances 0.000 description 1
- 229910052796 boron Inorganic materials 0.000 description 1
- 230000003435 bronchoconstrictive effect Effects 0.000 description 1
- 230000005587 bubbling Effects 0.000 description 1
- 125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- IKWKJIWDLVYZIY-UHFFFAOYSA-M butyl(triphenyl)phosphanium;bromide Chemical compound [Br-].C=1C=CC=CC=1[P+](C=1C=CC=CC=1)(CCCC)C1=CC=CC=C1 IKWKJIWDLVYZIY-UHFFFAOYSA-M 0.000 description 1
- 159000000007 calcium salts Chemical class 0.000 description 1
- 125000004432 carbon atom Chemical group C* 0.000 description 1
- 235000011089 carbon dioxide Nutrition 0.000 description 1
- JYYOBHFYCIDXHH-UHFFFAOYSA-N carbonic acid;hydrate Chemical compound O.OC(O)=O JYYOBHFYCIDXHH-UHFFFAOYSA-N 0.000 description 1
- 150000001735 carboxylic acids Chemical class 0.000 description 1
- 239000003054 catalyst Substances 0.000 description 1
- 230000002490 cerebral effect Effects 0.000 description 1
- 239000003610 charcoal Substances 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- WORJEOGGNQDSOE-UHFFFAOYSA-N chloroform;methanol Chemical compound OC.ClC(Cl)Cl WORJEOGGNQDSOE-UHFFFAOYSA-N 0.000 description 1
- 238000004587 chromatography analysis Methods 0.000 description 1
- 230000001684 chronic effect Effects 0.000 description 1
- 239000012230 colorless oil Substances 0.000 description 1
- 238000004440 column chromatography Methods 0.000 description 1
- 239000007891 compressed tablet Substances 0.000 description 1
- 238000007906 compression Methods 0.000 description 1
- 230000006835 compression Effects 0.000 description 1
- 230000037020 contractile activity Effects 0.000 description 1
- 230000008602 contraction Effects 0.000 description 1
- 230000001595 contractor effect Effects 0.000 description 1
- 230000036461 convulsion Effects 0.000 description 1
- 239000006071 cream Substances 0.000 description 1
- 229960002887 deanol Drugs 0.000 description 1
- 230000018109 developmental process Effects 0.000 description 1
- 238000007865 diluting Methods 0.000 description 1
- 239000003085 diluting agent Substances 0.000 description 1
- 239000012972 dimethylethanolamine Substances 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 230000006806 disease prevention Effects 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 239000002270 dispersing agent Substances 0.000 description 1
- 238000004821 distillation Methods 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 238000010828 elution Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- HBJKJBHQKGRVHW-UHFFFAOYSA-N ethanamine;propan-1-amine Chemical compound CCN.CCCN HBJKJBHQKGRVHW-UHFFFAOYSA-N 0.000 description 1
- IDGUHHHQCWSQLU-UHFFFAOYSA-N ethanol;hydrate Chemical compound O.CCO IDGUHHHQCWSQLU-UHFFFAOYSA-N 0.000 description 1
- 239000012259 ether extract Substances 0.000 description 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 1
- 239000007789 gas Substances 0.000 description 1
- 208000021302 gastroesophageal reflux disease Diseases 0.000 description 1
- 229960004275 glycolic acid Drugs 0.000 description 1
- 150000004795 grignard reagents Chemical class 0.000 description 1
- 150000004820 halides Chemical class 0.000 description 1
- 125000005843 halogen group Chemical group 0.000 description 1
- IXCSERBJSXMMFS-UHFFFAOYSA-N hydrogen chloride Substances Cl.Cl IXCSERBJSXMMFS-UHFFFAOYSA-N 0.000 description 1
- 229910000041 hydrogen chloride Inorganic materials 0.000 description 1
- 238000005984 hydrogenation reaction Methods 0.000 description 1
- 230000003301 hydrolyzing effect Effects 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 239000003701 inert diluent Substances 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 238000007918 intramuscular administration Methods 0.000 description 1
- 125000002510 isobutoxy group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])O* 0.000 description 1
- 229960000310 isoleucine Drugs 0.000 description 1
- AGPKZVBTJJNPAG-UHFFFAOYSA-N isoleucine Natural products CCC(C)C(N)C(O)=O AGPKZVBTJJNPAG-UHFFFAOYSA-N 0.000 description 1
- QFGMXJOBTNZHEL-UHFFFAOYSA-N isoxepac Chemical compound O1CC2=CC=CC=C2C(=O)C2=CC(CC(=O)O)=CC=C21 QFGMXJOBTNZHEL-UHFFFAOYSA-N 0.000 description 1
- 239000011777 magnesium Substances 0.000 description 1
- 229910052749 magnesium Inorganic materials 0.000 description 1
- LWLPYZUDBNFNAH-UHFFFAOYSA-M magnesium;butane;bromide Chemical compound [Mg+2].[Br-].CCC[CH2-] LWLPYZUDBNFNAH-UHFFFAOYSA-M 0.000 description 1
- FRIJBUGBVQZNTB-UHFFFAOYSA-M magnesium;ethane;bromide Chemical compound [Mg+2].[Br-].[CH2-]C FRIJBUGBVQZNTB-UHFFFAOYSA-M 0.000 description 1
- XGITVAYMIKUXIN-UHFFFAOYSA-M magnesium;propane;iodide Chemical compound [Mg+2].[I-].C[CH-]C XGITVAYMIKUXIN-UHFFFAOYSA-M 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 231100000544 menstrual irregularity Toxicity 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- UKVIEHSSVKSQBA-UHFFFAOYSA-N methane;palladium Chemical compound C.[Pd] UKVIEHSSVKSQBA-UHFFFAOYSA-N 0.000 description 1
- XNEFVTBPCXGIRX-UHFFFAOYSA-M methanesulfinate Chemical compound CS([O-])=O XNEFVTBPCXGIRX-UHFFFAOYSA-M 0.000 description 1
- HNQIVZYLYMDVSB-UHFFFAOYSA-N methanesulfonimidic acid Chemical compound CS(N)(=O)=O HNQIVZYLYMDVSB-UHFFFAOYSA-N 0.000 description 1
- BQYQKGKGXWHUQF-UHFFFAOYSA-N methyl 11-amino-6,11-dihydrobenzo[c][1]benzoxepine-2-carboxylate;hydrochloride Chemical compound Cl.O1CC2=CC=CC=C2C(N)C2=CC(C(=O)OC)=CC=C21 BQYQKGKGXWHUQF-UHFFFAOYSA-N 0.000 description 1
- JCNZIGFUEMUHJP-UHFFFAOYSA-N methyl 11-methoxy-6,11-dihydrobenzo[c][1]benzoxepine-2-carboxylate Chemical compound C1OC2=CC=C(C(=O)OC)C=C2C(OC)C2=CC=CC=C21 JCNZIGFUEMUHJP-UHFFFAOYSA-N 0.000 description 1
- ABPGJCTZRQMWJP-UHFFFAOYSA-N methyl 11-methylidene-6h-benzo[c][1]benzoxepine-2-carboxylate Chemical compound O1CC2=CC=CC=C2C(=C)C2=CC(C(=O)OC)=CC=C21 ABPGJCTZRQMWJP-UHFFFAOYSA-N 0.000 description 1
- ZDCLEGORHNAWNM-UHFFFAOYSA-N methyl 11-methylsulfonyl-6,11-dihydrobenzo[c][1]benzoxepine-2-carboxylate Chemical compound O1CC2=CC=CC=C2C(S(C)(=O)=O)C2=CC(C(=O)OC)=CC=C21 ZDCLEGORHNAWNM-UHFFFAOYSA-N 0.000 description 1
- OYTXLDILHSEQTE-UHFFFAOYSA-N methyl 11-phenylsulfanyl-6,11-dihydrobenzo[c][1]benzoxepine-2-carboxylate Chemical compound C12=CC(C(=O)OC)=CC=C2OCC2=CC=CC=C2C1SC1=CC=CC=C1 OYTXLDILHSEQTE-UHFFFAOYSA-N 0.000 description 1
- WVWZECQNFWFVFW-UHFFFAOYSA-N methyl 2-methylbenzoate Chemical compound COC(=O)C1=CC=CC=C1C WVWZECQNFWFVFW-UHFFFAOYSA-N 0.000 description 1
- SGFACFBLUAWICV-UHFFFAOYSA-N methyl 4-bromo-2-(bromomethyl)benzoate Chemical compound COC(=O)C1=CC=C(Br)C=C1CBr SGFACFBLUAWICV-UHFFFAOYSA-N 0.000 description 1
- FDCYLMYCHALQJR-UHFFFAOYSA-N methyl 5-bromo-2-methylbenzoate Chemical compound COC(=O)C1=CC(Br)=CC=C1C FDCYLMYCHALQJR-UHFFFAOYSA-N 0.000 description 1
- XLZZGBJGHRSHAI-UHFFFAOYSA-N methyl 6,11-dihydrobenzo[c][1]benzoxepine-2-carboxylate Chemical compound O1CC2=CC=CC=C2CC2=CC(C(=O)OC)=CC=C21 XLZZGBJGHRSHAI-UHFFFAOYSA-N 0.000 description 1
- GRVDJDISBSALJP-UHFFFAOYSA-N methyloxidanyl Chemical compound [O]C GRVDJDISBSALJP-UHFFFAOYSA-N 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 239000007932 molded tablet Substances 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
- 208000010125 myocardial infarction Diseases 0.000 description 1
- YKZKUQWOIKXDTG-UHFFFAOYSA-N n-methylsulfonyl-11-oxo-6h-benzo[c][1]benzoxepine-2-carboxamide Chemical compound O1CC2=CC=CC=C2C(=O)C2=CC(C(=O)NS(=O)(=O)C)=CC=C21 YKZKUQWOIKXDTG-UHFFFAOYSA-N 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 239000004533 oil dispersion Substances 0.000 description 1
- 150000007530 organic bases Chemical class 0.000 description 1
- 150000001451 organic peroxides Chemical class 0.000 description 1
- 239000007800 oxidant agent Substances 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- LPNBBFKOUUSUDB-UHFFFAOYSA-N p-toluic acid Chemical compound CC1=CC=C(C(O)=O)C=C1 LPNBBFKOUUSUDB-UHFFFAOYSA-N 0.000 description 1
- 230000020477 pH reduction Effects 0.000 description 1
- 150000004965 peroxy acids Chemical class 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 150000002989 phenols Chemical class 0.000 description 1
- 125000000951 phenoxy group Chemical group [H]C1=C([H])C([H])=C(O*)C([H])=C1[H] 0.000 description 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 1
- 229910052700 potassium Inorganic materials 0.000 description 1
- 239000011591 potassium Substances 0.000 description 1
- 159000000001 potassium salts Chemical class 0.000 description 1
- ZLMJMSJWJFRBEC-OUBTZVSYSA-N potassium-40 Chemical compound [40K] ZLMJMSJWJFRBEC-OUBTZVSYSA-N 0.000 description 1
- 230000003389 potentiating effect Effects 0.000 description 1
- 230000000069 prophylactic effect Effects 0.000 description 1
- 235000019260 propionic acid Nutrition 0.000 description 1
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 239000002089 prostaglandin antagonist Substances 0.000 description 1
- 230000002685 pulmonary effect Effects 0.000 description 1
- 238000010926 purge Methods 0.000 description 1
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 description 1
- IUVKMZGDUIUOCP-BTNSXGMBSA-N quinbolone Chemical compound O([C@H]1CC[C@H]2[C@H]3[C@@H]([C@]4(C=CC(=O)C=C4CC3)C)CC[C@@]21C)C1=CCCC1 IUVKMZGDUIUOCP-BTNSXGMBSA-N 0.000 description 1
- 230000008929 regeneration Effects 0.000 description 1
- 238000011069 regeneration method Methods 0.000 description 1
- 239000011347 resin Substances 0.000 description 1
- 229920005989 resin Polymers 0.000 description 1
- 239000012266 salt solution Substances 0.000 description 1
- 238000007493 shaping process Methods 0.000 description 1
- 238000010898 silica gel chromatography Methods 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- AKHNMLFCWUSKQB-UHFFFAOYSA-L sodium thiosulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=S AKHNMLFCWUSKQB-UHFFFAOYSA-L 0.000 description 1
- 235000019345 sodium thiosulphate Nutrition 0.000 description 1
- 208000000995 spontaneous abortion Diseases 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 239000006188 syrup Substances 0.000 description 1
- 235000020357 syrup Nutrition 0.000 description 1
- 239000011975 tartaric acid Substances 0.000 description 1
- 235000002906 tartaric acid Nutrition 0.000 description 1
- 238000011287 therapeutic dose Methods 0.000 description 1
- WFKWXMTUELFFGS-UHFFFAOYSA-N tungsten Chemical compound [W] WFKWXMTUELFFGS-UHFFFAOYSA-N 0.000 description 1
- 229910052721 tungsten Inorganic materials 0.000 description 1
- 239000010937 tungsten Substances 0.000 description 1
Landscapes
- Pyrane Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Description
ãçºæã®è©³çŽ°ãªèª¬æã
æ¬çºæã¯ãžãã³ããªãã»ãã³ã®ãããªææ©ååŠ
ã®åéã§åé¡ã§ããç©è³ªã®æ°èŠãªãããŠæçšãªçµ
æç©ã«é¢ãããã®ã§ãããããã«è©³çŽ°ã«ã¯æ¬çºæ
ã¯ïŒïŒ11âãžããããžãã³ããïœïŒïœããªãã»ã
ã³ã®æ°èŠãªçŸ€ããããååç©ã®è£œé æ¹æ³ã«é¢ã
ããæ¬çºæã®ååç©ã¯ãåæ¯ã®ãããªã¢ã¬ã«ã®ãŒ
æ§çç¶ã®æ²»çåã³å¶åŸ¡ã«æçšã§ããã
ã®åéã§åé¡ã§ããç©è³ªã®æ°èŠãªãããŠæçšãªçµ
æç©ã«é¢ãããã®ã§ãããããã«è©³çŽ°ã«ã¯æ¬çºæ
ã¯ïŒïŒ11âãžããããžãã³ããïœïŒïœããªãã»ã
ã³ã®æ°èŠãªçŸ€ããããååç©ã®è£œé æ¹æ³ã«é¢ã
ããæ¬çºæã®ååç©ã¯ãåæ¯ã®ãããªã¢ã¬ã«ã®ãŒ
æ§çç¶ã®æ²»çåã³å¶åŸ¡ã«æçšã§ããã
ããªãã¡æ¬çºæã¯åŒ
ãåŒäžãR1åã³R3ã¯ç¬ç«çã«æ°ŽçŽ ãã«ã«ããã·ã
äœçŽã¢ã«ã³ãã·ã«ã«ããã«ãïŒâããã©ãŸãªã«ã
ïŒâããããã·âïŒïŒïŒïŒïŒâãã¢ãžã¢ãŸãŒã«â
ïŒâã€ã«ãïŒâããããã·âÎ3âãããªã³âïŒïŒ
ïŒâãžãªã³âïŒâã€ã«åã¯ïŒïŒ®âã¡ãã«âïŒâã
ã¢ãŸãªãžããªãã³ïŒã«ã«ãã¢ã€ã«ã§ããããã®
éãR1ãšR3ã®äžæ¹ã¯æ°ŽçŽ ã§ãããä»æ¹ã¯æ°ŽçŽ 以
å€ã§ããïŒ R2ã¯æ°ŽçŽ åã¯äœçŽã¢ã«ãã«ã§ããããåã¯R1
ãšR2ãäžç·ã«ãªã€ãŠã¡ãã¬ã³ãžãªãã·ã圢æã
ãïŒ R4ã¯æ°ŽçŽ ãããããã·ãäœçŽã¢ã«ãã«ã¹ã«ã
ãã«ãäœçŽã¢ã«ãã«ããªãäœçŽã¢ã«ã³ãã·ãã€ã
ããŸãªã«åã¯ã¢ããã§ããããåã¯R4ãšR5ã¯äž
ç·ã«ãªã€ãŠïŒïŒ¯åã¯ïŒCH2ã圢æãããã®éã
R4ãšR5ãšãïŒïŒ¯ã圢æãããããŠR2ãšR3ãšãæ°Ž
çŽ ã®å Žåã«ãR1ã¯ïŒâããã©ãŸãªã«åã³ã«ã«ã
ãã·ä»¥å€ã®ãã®ã§ãããã§è¡šããããç°æ§äœïŒïŒ
11âãžããããžãã³ãïœïŒïœ ãªãã»ãã³åã³
ãã®è¬åŠçã®èš±å®¹ãããå¡©ãæŽã«ãã®æ²»çåŠçã«
æå¹ãªéãå¿ é ã®æŽ»æ§æåãšããŠå«æããåäœäœ¿
çšåœ¢æ ã®è¬åŠçµæç©ã§ããã
äœçŽã¢ã«ã³ãã·ã«ã«ããã«ãïŒâããã©ãŸãªã«ã
ïŒâããããã·âïŒïŒïŒïŒïŒâãã¢ãžã¢ãŸãŒã«â
ïŒâã€ã«ãïŒâããããã·âÎ3âãããªã³âïŒïŒ
ïŒâãžãªã³âïŒâã€ã«åã¯ïŒïŒ®âã¡ãã«âïŒâã
ã¢ãŸãªãžããªãã³ïŒã«ã«ãã¢ã€ã«ã§ããããã®
éãR1ãšR3ã®äžæ¹ã¯æ°ŽçŽ ã§ãããä»æ¹ã¯æ°ŽçŽ 以
å€ã§ããïŒ R2ã¯æ°ŽçŽ åã¯äœçŽã¢ã«ãã«ã§ããããåã¯R1
ãšR2ãäžç·ã«ãªã€ãŠã¡ãã¬ã³ãžãªãã·ã圢æã
ãïŒ R4ã¯æ°ŽçŽ ãããããã·ãäœçŽã¢ã«ãã«ã¹ã«ã
ãã«ãäœçŽã¢ã«ãã«ããªãäœçŽã¢ã«ã³ãã·ãã€ã
ããŸãªã«åã¯ã¢ããã§ããããåã¯R4ãšR5ã¯äž
ç·ã«ãªã€ãŠïŒïŒ¯åã¯ïŒCH2ã圢æãããã®éã
R4ãšR5ãšãïŒïŒ¯ã圢æãããããŠR2ãšR3ãšãæ°Ž
çŽ ã®å Žåã«ãR1ã¯ïŒâããã©ãŸãªã«åã³ã«ã«ã
ãã·ä»¥å€ã®ãã®ã§ãããã§è¡šããããç°æ§äœïŒïŒ
11âãžããããžãã³ãïœïŒïœ ãªãã»ãã³åã³
ãã®è¬åŠçã®èš±å®¹ãããå¡©ãæŽã«ãã®æ²»çåŠçã«
æå¹ãªéãå¿ é ã®æŽ»æ§æåãšããŠå«æããåäœäœ¿
çšåœ¢æ ã®è¬åŠçµæç©ã§ããã
æ¬çºæã®ååç©ã«ãããŠã¯R4ããã³R5ãäžç·
ã«çµåããŠïŒïŒ¯ã§ãããR2ããã³R3ãæ°ŽçŽ ã§ã
ãå ŽåãR1ãïŒâããã©ãŸãªã«åã³ã«ã«ãããµ
ããã§ãªããšããæ¡ä»¶ã§R1ãR2ãR3ãR4ããã³
R5ãæ¬æ现æžäžã§å®çŸ©ããéãã§ãããR1ãïŒ
âããã©ãŸãªã«ãŸãã¯ãŸãã¯ã«ã«ãããµããã§ã
ããR4ããã³R5ãäžç·ã«çµåããŠïŒïŒ¯ã§ããã
ãã³R2ããã³R3ãæ°ŽçŽ ã§ããååç©ã¯æççå€
ã®ããã«å è¡æè¡ã§ç¥ãããŠããïŒJ.Med.Chem.
第21å·»ãNo.ïŒã第633ã639é ã1978幎åç §ïŒãã
ããååç©ãæ¬çºæã®ç¯å²ã§ã¯ãªãã
ã«çµåããŠïŒïŒ¯ã§ãããR2ããã³R3ãæ°ŽçŽ ã§ã
ãå ŽåãR1ãïŒâããã©ãŸãªã«åã³ã«ã«ãããµ
ããã§ãªããšããæ¡ä»¶ã§R1ãR2ãR3ãR4ããã³
R5ãæ¬æ现æžäžã§å®çŸ©ããéãã§ãããR1ãïŒ
âããã©ãŸãªã«ãŸãã¯ãŸãã¯ã«ã«ãããµããã§ã
ããR4ããã³R5ãäžç·ã«çµåããŠïŒïŒ¯ã§ããã
ãã³R2ããã³R3ãæ°ŽçŽ ã§ããååç©ã¯æççå€
ã®ããã«å è¡æè¡ã§ç¥ãããŠããïŒJ.Med.Chem.
第21å·»ãNo.ïŒã第633ã639é ã1978幎åç §ïŒãã
ããååç©ãæ¬çºæã®ç¯å²ã§ã¯ãªãã
æ¬æ现æžäžã«äœ¿çšãããçšèªäœçŽã¢ã«ãã«ãã
ã³äœçŽã¢ã«ã³ãã·ã¯äœ¿çšãããæã¯å¿ ããããŠç¹
ã«ããšãããªãéããã¢ã«ãã«ãŸãã¯ã¢ã«ã³ãã·
éšåå ·äœäŸãšããŠã¡ãã«ããšãã«ãã€ãœããã
ã«ãããã«ããšããã·ãããããã·ããã³ã€ãœã
ããã·ãªã©ã«ïŒãïŒåã®ççŽ ååãæããçŽéã
ãã³åæéã¢ã«ãã«ããã³ã¢ã«ã³ãã·åºãå å«ã
ãã
ã³äœçŽã¢ã«ã³ãã·ã¯äœ¿çšãããæã¯å¿ ããããŠç¹
ã«ããšãããªãéããã¢ã«ãã«ãŸãã¯ã¢ã«ã³ãã·
éšåå ·äœäŸãšããŠã¡ãã«ããšãã«ãã€ãœããã
ã«ãããã«ããšããã·ãããããã·ããã³ã€ãœã
ããã·ãªã©ã«ïŒãïŒåã®ççŽ ååãæããçŽéã
ãã³åæéã¢ã«ãã«ããã³ã¢ã«ã³ãã·åºãå å«ã
ãã
æ¬çºæã¯äžèšåŒããã³ïŒ¡ã®ãªãã»ãã³ã
PGR2ããPGG2ãPGH2ããã³TXA2ã®ãããªå
çž®æ§ã®ããã¹ã¿ã°ã©ã³ãžã³ã®äœçšã«èããæ®æã
ããšããåºé¡äººã®çºèŠã«åºã¥ããã®ã§ããããã
ã¹ã¿ã°ã©ã³ãžã³æ®æç©è³ªããã³çåæé»å®³å€ãšã
ãŠäœçšããæ¬çºæã®ãªãã»ãã³ã®äœ¿çšã¯ããã¹ã¿
ã°ã©ã³ãžã³ããã³ããã¹ã¿ã°ã©ã³ãžã³çåæäžé
äœã®é床ãªåçž®äœçšãçããã¢ã¬ã«ã®ãŒæ§åæ¯ã®
ãããªã¢ã¬ã«ã®ãŒæ§çç¶ã®å€åã«ãããŠæ²»çãã
ããã«æ°ããåŠçæ¹æ³ãæäŸãããäŸãã°
PGF2ããPGG2ãTXA2 *ããã³PGH2ã¯æ°ç®¡æ¯ç
ã®å¹èœã®ããåçž®å€ã§ããããããŠããã®åæ¯æ£
è ãPGF2ãã®æ°ç®¡æ¯åçž®äœçšã«ç¹ã«æåæ§ããã
ããšã¯ããç¥ãããŠãããåçž®æ§ããã¹ã¿ã°ã©ã³
ãžã³ã®åçž®äœçšã«å¯Ÿããæ¬çºæã®ãªãã»ãã³ã®æ®
æäœçšã¯æšæºã®è¬çæè¡ãçšããŠè©Šéšç®¡å ã§ãã
ã³çäœå ã§ç¢ºèªãããŠãããããæ æ¬çºæã®ãªã
ã»ãã³ã¯ããããã³æž©è¡åç©ã®åæ¯ã®ãããªã¢ã¬
ã«ã®ãŒæ§çç¶ã®æ²»çããã³å¶åŸ¡ããããã®å»è¬åŠ
æ¹ç©ã«ãããå¿ é 掻æ§æåãšããŠæçšåäœåœ¢æ ã«
䜿çšããããšãèããããã
PGR2ããPGG2ãPGH2ããã³TXA2ã®ãããªå
çž®æ§ã®ããã¹ã¿ã°ã©ã³ãžã³ã®äœçšã«èããæ®æã
ããšããåºé¡äººã®çºèŠã«åºã¥ããã®ã§ããããã
ã¹ã¿ã°ã©ã³ãžã³æ®æç©è³ªããã³çåæé»å®³å€ãšã
ãŠäœçšããæ¬çºæã®ãªãã»ãã³ã®äœ¿çšã¯ããã¹ã¿
ã°ã©ã³ãžã³ããã³ããã¹ã¿ã°ã©ã³ãžã³çåæäžé
äœã®é床ãªåçž®äœçšãçããã¢ã¬ã«ã®ãŒæ§åæ¯ã®
ãããªã¢ã¬ã«ã®ãŒæ§çç¶ã®å€åã«ãããŠæ²»çãã
ããã«æ°ããåŠçæ¹æ³ãæäŸãããäŸãã°
PGF2ããPGG2ãTXA2 *ããã³PGH2ã¯æ°ç®¡æ¯ç
ã®å¹èœã®ããåçž®å€ã§ããããããŠããã®åæ¯æ£
è ãPGF2ãã®æ°ç®¡æ¯åçž®äœçšã«ç¹ã«æåæ§ããã
ããšã¯ããç¥ãããŠãããåçž®æ§ããã¹ã¿ã°ã©ã³
ãžã³ã®åçž®äœçšã«å¯Ÿããæ¬çºæã®ãªãã»ãã³ã®æ®
æäœçšã¯æšæºã®è¬çæè¡ãçšããŠè©Šéšç®¡å ã§ãã
ã³çäœå ã§ç¢ºèªãããŠãããããæ æ¬çºæã®ãªã
ã»ãã³ã¯ããããã³æž©è¡åç©ã®åæ¯ã®ãããªã¢ã¬
ã«ã®ãŒæ§çç¶ã®æ²»çããã³å¶åŸ¡ããããã®å»è¬åŠ
æ¹ç©ã«ãããå¿ é 掻æ§æåãšããŠæçšåäœåœ¢æ ã«
䜿çšããããšãèããããã
ïŒ TXA2ã¯ããã ãããµã³âA2ãšããŠé垞䜿
çšãããç¥èªã§ããã
çšãããç¥èªã§ããã
æ¬çºæã®æ°èŠãªïŒïŒ11âãžãããâ11âãªããœ
ãžãã³ããb.eããªãã»ãã³ã¯æ¬¡ã®æ§é åŒïŒ ããã³ ïŒåŒäžR1ãR2ããã³R3ã¯åã«å®çŸ©ããéãã§ã
ããïŒãæããïŒâïŒãŸãã¯ïŒïŒâã·ã¢ãäžéäœã
ã補é ãããããããã®ïŒâïŒãŸãã¯ïŒïŒâã·ã¢ã
âïŒïŒ11âãžãããâ11âãªããœãžãã³ããb.eã
ãªãã»ãã³äžéäœã¯åžè²©ã§å ¥æãåŸããŸãã¯ååŠ
æç®ã«ãã§ã«ååã«èšèŒãããŠããéäŸã®æè¡ã«
ãã€ãŠè£œé ããããšãã§ããå ¬ç¥ã®åºçºç©è³ªãã
容æã«è£œé ãããã
ãžãã³ããb.eããªãã»ãã³ã¯æ¬¡ã®æ§é åŒïŒ ããã³ ïŒåŒäžR1ãR2ããã³R3ã¯åã«å®çŸ©ããéãã§ã
ããïŒãæããïŒâïŒãŸãã¯ïŒïŒâã·ã¢ãäžéäœã
ã補é ãããããããã®ïŒâïŒãŸãã¯ïŒïŒâã·ã¢ã
âïŒïŒ11âãžãããâ11âãªããœãžãã³ããb.eã
ãªãã»ãã³äžéäœã¯åžè²©ã§å ¥æãåŸããŸãã¯ååŠ
æç®ã«ãã§ã«ååã«èšèŒãããŠããéäŸã®æè¡ã«
ãã€ãŠè£œé ããããšãã§ããå ¬ç¥ã®åºçºç©è³ªãã
容æã«è£œé ãããã
ããšãã°ïŒâã·ã¢ãâïŒïŒ11âãžãããâ11â
ãªããœãžãã³ããb.eããªãã»ãã³ïŒïŒã次ã®
äžè¬åå¿å³åŒã«åŸã€ãŠè£œé ããããšãã§ããã
ãªããœãžãã³ããb.eããªãã»ãã³ïŒïŒã次ã®
äžè¬åå¿å³åŒã«åŸã€ãŠè£œé ããããšãã§ããã
åŒäžR2â²åã³R3â²ã¯ãããããR2ããã³R3ã®å®
矩ãšåããã®ãæå³ãããïŒé©åœã«çœ®æããã
R2â²ããã³ïŒãŸãã¯R3â²Oâã€ã«ã€ã«é žãå¡©åããª
ãã«ã§åŠçããŠå¯Ÿå¿ããé žã¯ãã©ã€ããåŸã次ã«
ã¡ã¿ããŒã«ïŒãŸãã¯ããããææã®äœçŽã¢ã«ã«ã
ãŒã«ïŒã§åŠçããŠå¯Ÿå¿ããã¡ãã«ïŒãŸãã¯äœçŽã¢
ã«ãã«ïŒãšã¹ãã«ãåŸãããšã«ããã次ãã§ãšã¹
ãã«ãâããã¢ãµã¯ã·ã³ã€ããã§éæµããŠå¯Ÿå¿
ããã¡ãã«ïŒãŸãã¯äœçŽã¢ã«ãã«ïŒÎ±âããã¢â
âãã«ãšãŒããçæããïœâããã¢ããšããŒã«
ãšåå¿ããŠå¯Ÿå¿ããã¡ãã«ïŒãŸãã¯äœçŽã¢ã«ã
ã«ïŒââïŒïœâããã¢ããšããã·ïŒãã³ãŸãšãŒã
ãåŸãããã®ååç©ã®å æ°Žå解ã¯å¯Ÿå¿ããâ
ïŒïœâããã¢ããšããã·ã¡ãã«ïŒå®æ¯éŠé žãçæ
ãããäžããåããŠçŽ âãšãŒãã«è€åäœã®ååš
äžãé žãããªãã«ãªãé ¢é žç¡æ°Žç©ã§ã®ç°åã¯å¯Ÿå¿
ããïŒâããã¢âïŒïŒ11âãžãããâ11âãªããœ
ãžãã³ããb.eããªãã»ãã³ãçæãããã·ã¢ã
åºã¯ïŒ®ïŒïŒ®âãžã¡ãã«ãã«ã ã¢ããäžéæµäžãïŒ
âããã¢ååç©ãã·ã¢ã³å第äžé ã§åŠçããããš
ã«ãã€ãŠå°å ¥ãããåŒã®ææã®R2â²ããã³ïŒ
R3â²çœ®æïŒâã·ã¢ãâïŒïŒ11âãžãããâ11âãª
ããœãžãã³ããb.eããªãã»ãã³ãçæããã
矩ãšåããã®ãæå³ãããïŒé©åœã«çœ®æããã
R2â²ããã³ïŒãŸãã¯R3â²Oâã€ã«ã€ã«é žãå¡©åããª
ãã«ã§åŠçããŠå¯Ÿå¿ããé žã¯ãã©ã€ããåŸã次ã«
ã¡ã¿ããŒã«ïŒãŸãã¯ããããææã®äœçŽã¢ã«ã«ã
ãŒã«ïŒã§åŠçããŠå¯Ÿå¿ããã¡ãã«ïŒãŸãã¯äœçŽã¢
ã«ãã«ïŒãšã¹ãã«ãåŸãããšã«ããã次ãã§ãšã¹
ãã«ãâããã¢ãµã¯ã·ã³ã€ããã§éæµããŠå¯Ÿå¿
ããã¡ãã«ïŒãŸãã¯äœçŽã¢ã«ãã«ïŒÎ±âããã¢â
âãã«ãšãŒããçæããïœâããã¢ããšããŒã«
ãšåå¿ããŠå¯Ÿå¿ããã¡ãã«ïŒãŸãã¯äœçŽã¢ã«ã
ã«ïŒââïŒïœâããã¢ããšããã·ïŒãã³ãŸãšãŒã
ãåŸãããã®ååç©ã®å æ°Žå解ã¯å¯Ÿå¿ããâ
ïŒïœâããã¢ããšããã·ã¡ãã«ïŒå®æ¯éŠé žãçæ
ãããäžããåããŠçŽ âãšãŒãã«è€åäœã®ååš
äžãé žãããªãã«ãªãé ¢é žç¡æ°Žç©ã§ã®ç°åã¯å¯Ÿå¿
ããïŒâããã¢âïŒïŒ11âãžãããâ11âãªããœ
ãžãã³ããb.eããªãã»ãã³ãçæãããã·ã¢ã
åºã¯ïŒ®ïŒïŒ®âãžã¡ãã«ãã«ã ã¢ããäžéæµäžãïŒ
âããã¢ååç©ãã·ã¢ã³å第äžé ã§åŠçããããš
ã«ãã€ãŠå°å ¥ãããåŒã®ææã®R2â²ããã³ïŒ
R3â²çœ®æïŒâã·ã¢ãâïŒïŒ11âãžãããâ11âãª
ããœãžãã³ããb.eããªãã»ãã³ãçæããã
ïŒâã·ã¢ãâïŒïŒ11âãžãããâ11âãªããœãž
ãã³ããb.eããªãã»ãã³ïŒïŒ¡ïŒã次ã®äžè¬å
å¿å³åŒã«åŸã€ãŠè£œé ããããšãã§ããã
ãã³ããb.eããªãã»ãã³ïŒïŒ¡ïŒã次ã®äžè¬å
å¿å³åŒã«åŸã€ãŠè£œé ããããšãã§ããã
åŒäžR2â²åã³R3â²ã¯ãããããR2ããã³R3ã®å®
矩ãšåããã®ãæå³ãããâãã«ã€ã«é žãéæ«
ã®ååšäžèçŽ ãšåå¿ãããŠïŒâããã¢ââãã«
ã€ã«é žãåŸãããšã«ãããåå¿æ··åç©ããåŸãç
æç©ã¯ïŒâããã¢ç°æ§äœãããããååšããããš
ãã§ããããã©ãææã®ïŒâããã¢ç°æ§äœãåªäœ
ã§ãããææãªãã°çŽç²ãªïŒâããã¢ç°æ§äœãé
åžžã®æè¡ã«ãã€ãŠåé¢ããããšãã§ãã次ã®æ®µé
ã®ããã®åºçºç©è³ªãšããŠçŽç²ãªåœ¢æ ã§äœ¿çšããã
ãšãã§ãããããããªããåé¢ã¯äžèŠã§ãããå
å¿æ··åç©ããåŸãããçæç©ã¯éåžžããã«ç²Ÿè£œã
ãã«æ¬¡ã®æ®µéã§äœ¿çšãããïŒâããã¢é žã次ã«ç¡«
é žã®ãããªåŒ·é žã®ååšäžã¡ã¿ããŒã«ïŒãŸãã¯ãã
ããææã®äœçŽã¢ã«ã«ããŒã«ïŒã§åŠçããŠã¡ãã«
ïŒãŸãã¯äœçŽã¢ã«ãã«ïŒãšã¹ãã«ãçæãã次ã«
éæµäžããã³ãŸã€ã«ããŒãªããµã€ãã®ååšäžã§ïŒ®
âããã¢ãµã¯ã·ã³ã€ããã§åŠçããŠã¡ãã«ïŒãŸã
ã¯äœçŽã¢ã«ãã«ïŒÎ±ïŒïŒâãžããã¢ââãã«ãš
ãŒããçæããããžããã¢ãšã¹ãã«ã次ã«ãžã¡ã
ã«ãã«ã ã¢ããããã³çé žã«ãªãŠã ã®ååšäžã§é©
åœã«çœ®æããR2â²ããã³ïŒãŸãã¯R3â²ããšããŒã«ãš
åå¿ããã察å¿ããã¡ãã«ïŒãŸãã¯äœçŽã¢ã«ã
ã«ïŒïŒâããã¢âαâïŒR2â²ããã³ïŒãŸãã¯R3â²çœ®
æããšããã·ïŒââãã«ãšãŒããåŸããã¡ã¿ã
ãŒã«ããã³æ°Žé žåãããªãŠã ã§ã®ãšã¹ãã«ã®å æ°Ž
å解ã¯é žæ§åã®ééé¢é žãçæãããã®æããªã
ã«ãªãé ¢é žç¡æ°Žç©ããã³äžããåããŠçŽ âãšãã«
ãšãŒãã«è€åäœã®ååšäžã§ç°åããŠå¯Ÿå¿ããïŒâ
ããã¢âïŒïŒ11âãžãããâ11âãªããœãžãã³ã
ãb.eããªãã»ãã³ãçæãããã·ã¢ãåºããžã¡ã
ã«ãã«ã ã¢ããã®ååšäžã·ã¢ã³å第äžé ã§ïŒâã
ãã¢ååç©ãåŠçããããšã«ãã€ãŠåã«èšèŒãã
ããã«å°å ¥ããåŒïŒ¡ã®ææã®R2â²ããã³ïŒãŸã
ã¯R3â²çœ®æïŒâã·ã¢ãâïŒïŒ11âãžãããâ11â
ãªããœãžãã³ããb.eããªãã»ãã³ãåŸãã
矩ãšåããã®ãæå³ãããâãã«ã€ã«é žãéæ«
ã®ååšäžèçŽ ãšåå¿ãããŠïŒâããã¢ââãã«
ã€ã«é žãåŸãããšã«ãããåå¿æ··åç©ããåŸãç
æç©ã¯ïŒâããã¢ç°æ§äœãããããååšããããš
ãã§ããããã©ãææã®ïŒâããã¢ç°æ§äœãåªäœ
ã§ãããææãªãã°çŽç²ãªïŒâããã¢ç°æ§äœãé
åžžã®æè¡ã«ãã€ãŠåé¢ããããšãã§ãã次ã®æ®µé
ã®ããã®åºçºç©è³ªãšããŠçŽç²ãªåœ¢æ ã§äœ¿çšããã
ãšãã§ãããããããªããåé¢ã¯äžèŠã§ãããå
å¿æ··åç©ããåŸãããçæç©ã¯éåžžããã«ç²Ÿè£œã
ãã«æ¬¡ã®æ®µéã§äœ¿çšãããïŒâããã¢é žã次ã«ç¡«
é žã®ãããªåŒ·é žã®ååšäžã¡ã¿ããŒã«ïŒãŸãã¯ãã
ããææã®äœçŽã¢ã«ã«ããŒã«ïŒã§åŠçããŠã¡ãã«
ïŒãŸãã¯äœçŽã¢ã«ãã«ïŒãšã¹ãã«ãçæãã次ã«
éæµäžããã³ãŸã€ã«ããŒãªããµã€ãã®ååšäžã§ïŒ®
âããã¢ãµã¯ã·ã³ã€ããã§åŠçããŠã¡ãã«ïŒãŸã
ã¯äœçŽã¢ã«ãã«ïŒÎ±ïŒïŒâãžããã¢ââãã«ãš
ãŒããçæããããžããã¢ãšã¹ãã«ã次ã«ãžã¡ã
ã«ãã«ã ã¢ããããã³çé žã«ãªãŠã ã®ååšäžã§é©
åœã«çœ®æããR2â²ããã³ïŒãŸãã¯R3â²ããšããŒã«ãš
åå¿ããã察å¿ããã¡ãã«ïŒãŸãã¯äœçŽã¢ã«ã
ã«ïŒïŒâããã¢âαâïŒR2â²ããã³ïŒãŸãã¯R3â²çœ®
æããšããã·ïŒââãã«ãšãŒããåŸããã¡ã¿ã
ãŒã«ããã³æ°Žé žåãããªãŠã ã§ã®ãšã¹ãã«ã®å æ°Ž
å解ã¯é žæ§åã®ééé¢é žãçæãããã®æããªã
ã«ãªãé ¢é žç¡æ°Žç©ããã³äžããåããŠçŽ âãšãã«
ãšãŒãã«è€åäœã®ååšäžã§ç°åããŠå¯Ÿå¿ããïŒâ
ããã¢âïŒïŒ11âãžãããâ11âãªããœãžãã³ã
ãb.eããªãã»ãã³ãçæãããã·ã¢ãåºããžã¡ã
ã«ãã«ã ã¢ããã®ååšäžã·ã¢ã³å第äžé ã§ïŒâã
ãã¢ååç©ãåŠçããããšã«ãã€ãŠåã«èšèŒãã
ããã«å°å ¥ããåŒïŒ¡ã®ææã®R2â²ããã³ïŒãŸã
ã¯R3â²çœ®æïŒâã·ã¢ãâïŒïŒ11âãžãããâ11â
ãªããœãžãã³ããb.eããªãã»ãã³ãåŸãã
ïŒâïŒãŸãã¯ïŒïŒäœã®çœ®æåºãã«ã«ããã·ã§ã
ãæ¬çºæã®æ°èŠãªïŒïŒ11âãžãããâ11âãªããœ
ãžãã³ããb.eããªãã»ãã³ã¯æ°Žæ§å¡©é žããã³æ°·
é ¢é žã®æ··å液äžåŒãŸãã¯ïŒ¡ã®ïŒâïŒãŸãã¯ïŒïŒ
âã·ã¢ãäžéäœãéæµããããšã«ãã€ãŠè£œé ã
ããåå¿ã¯éåžžå®çµã«18ã160æéãå¿ èŠãšãã
åŒãŸãã¯ïŒ¡ã®ææã®ïŒïŒ11âãžãããâ11â
ãªããœãžãã³ããb.eããªãã»ãã³âïŒâïŒãŸãã¯
ïŒïŒâã«ã«ãã³é žãå·åŽæåå¿æ··å液ããååã
ãã
ãæ¬çºæã®æ°èŠãªïŒïŒ11âãžãããâ11âãªããœ
ãžãã³ããb.eããªãã»ãã³ã¯æ°Žæ§å¡©é žããã³æ°·
é ¢é žã®æ··å液äžåŒãŸãã¯ïŒ¡ã®ïŒâïŒãŸãã¯ïŒïŒ
âã·ã¢ãäžéäœãéæµããããšã«ãã€ãŠè£œé ã
ããåå¿ã¯éåžžå®çµã«18ã160æéãå¿ èŠãšãã
åŒãŸãã¯ïŒ¡ã®ææã®ïŒïŒ11âãžãããâ11â
ãªããœãžãã³ããb.eããªãã»ãã³âïŒâïŒãŸãã¯
ïŒïŒâã«ã«ãã³é žãå·åŽæåå¿æ··å液ããååã
ãã
ïŒâïŒãŸãã¯ïŒïŒäœã®çœ®æåºãïŒâããã©ãŸãª
ã«ã§ããæ¬çºæã®æ°èŠãªïŒïŒ11âãžãããâ11â
ãªããœãžãã³ããb.eããªãã»ãã³ããŸãåŒãŸ
ãã¯ïŒ¡ã®ïŒâïŒãŸãã¯ïŒïŒã·ã¢ãäžéäœãã補
é ããããããªã«ããžã¡ãã«ãã«ã ã¢ããã®ãã
ãªé©åœãªææ©æº¶åªäžã¢ãžããããªãŠã ããã³å¡©å
ã¢ã³ã¢ããŠã ã®æ··å液äžã§å ç±ãããéäŸåå¿ã¯
éæµã§è¡ãªããéåžžå®çµã«ïŒã30æéãå¿ èŠãšã
ããéå°ã®æ°ŽãŸãã¯éå°ã®çé žãããªãŠã ã§åžé
ãããšãã«ã¢ã»ããŒãã§æœåºããåŸãæ°Žçžãé žæ§
åããåŒãŸãã¯ïŒ¡ã®ææã®ïŒâïŒãŸãã¯ïŒâïŒ
âïŒ1Hâããã©ãŸãŒã«âïŒâã€ã«ïŒâïŒïŒ11âãž
ãããâ11âãªããœãžãã³ããb.eããªãã»ãã³
ãåŸãã
ã«ã§ããæ¬çºæã®æ°èŠãªïŒïŒ11âãžãããâ11â
ãªããœãžãã³ããb.eããªãã»ãã³ããŸãåŒãŸ
ãã¯ïŒ¡ã®ïŒâïŒãŸãã¯ïŒïŒã·ã¢ãäžéäœãã補
é ããããããªã«ããžã¡ãã«ãã«ã ã¢ããã®ãã
ãªé©åœãªææ©æº¶åªäžã¢ãžããããªãŠã ããã³å¡©å
ã¢ã³ã¢ããŠã ã®æ··å液äžã§å ç±ãããéäŸåå¿ã¯
éæµã§è¡ãªããéåžžå®çµã«ïŒã30æéãå¿ èŠãšã
ããéå°ã®æ°ŽãŸãã¯éå°ã®çé žãããªãŠã ã§åžé
ãããšãã«ã¢ã»ããŒãã§æœåºããåŸãæ°Žçžãé žæ§
åããåŒãŸãã¯ïŒ¡ã®ææã®ïŒâïŒãŸãã¯ïŒâïŒ
âïŒ1Hâããã©ãŸãŒã«âïŒâã€ã«ïŒâïŒïŒ11âãž
ãããâ11âãªããœãžãã³ããb.eããªãã»ãã³
ãåŸãã
ïŒâïŒãŸãã¯ïŒïŒäœã®çœ®æåºãïŒâããããã·
âïŒïŒïŒïŒïŒâãã¢ãžã¢ãŸãŒã«âïŒâã€ã«ã§ãã
æ¬çºæã®ãããã®ïŒïŒ11âãžãããâ11âãªããœ
ãžãã³ããb.eããªãã»ãã³ã¯ã©ãâããã±ã«å
éã®ååšäžãã®é žäžåŒãŸãã¯ïŒ¡ã®ïŒâïŒãŸã
ã¯ïŒïŒâã·ã¢ãäžéäœãéæµããããšã«ãã€ãŠè£œ
é ãã察å¿ããïŒïŒ11âãžãããâ11âãªããœãž
ãã³ããb.eããªãã»ãã³âïŒâïŒãŸãã¯ïŒïŒâã«
ã«ãããµã«ããããåŸããã¢ã«ãããçæç©ã次
ã«ã¢ã³ã¢ãã¢ã§é£œåããã¢ã«ã³ãŒã«æ§æº¶åªäžãã
ã³å¡©åã¢ã³ã¢ããŠã ããã³æ°Žé žåã¢ã³ã¢ããŠã ã®
ååšäžã·ã¢ã³åãããªãŠã ã§åŠçããŠå¯Ÿå¿ããïŒ
âïŒãŸãã¯ïŒïŒâïŒïŒâã¢ããã¢ã»ããããªã«ïŒã«
転åãããåå¿ã¯é垞宀枩ã§è¡ãªãããå®çµã«ïŒ
ã16æéãå¿ èŠãšããããã®ããã«è£œé ããã¢ã
ãã¢ã»ããããªã«ãæ¿å¡©é žã§å®€æž©ã«ãããŠ20ã45
åéåŠçããŠå¯Ÿå¿ããïŒâïŒãŸãã¯ïŒïŒâïŒïŒâã¢
ããã¢ã»ãã¢ããïŒãåŸã次ã«ãžã¡ãã«ãã«ã ã¢
ããäžãäžå¡©åã€ãªãŠã§åŠçããŠåŒããã³ïŒ¡
ã®ææã®ïŒâïŒãŸãã¯ïŒïŒâïŒïŒâããããã·âïŒïŒ
ïŒïŒïŒâãã¢ãžã¢ãŸãŒã«âïŒâã€ã«ïŒâïŒïŒ11â
ãžãããâ11âãªããœãžãã³ããb.eããªãã»ã
ã³ãåŸãããã®åå¿é åºã¯æ¬¡ã®å³åŒã«å ·äœçã«ç€º
ããæçµçæç©ã®ïŒâããããã·âïŒïŒïŒïŒïŒâ
ãã¢ãžã¢ãŸãŒã«âïŒâã€ã«çœ®æåºã®äœçœ®ãé©åœãª
ïŒâïŒãŸãã¯ïŒïŒâã·ã¢ãåºçºç©è³ªã®éžæã«äŸåã
ãããšãç解ãããã
âïŒïŒïŒïŒïŒâãã¢ãžã¢ãŸãŒã«âïŒâã€ã«ã§ãã
æ¬çºæã®ãããã®ïŒïŒ11âãžãããâ11âãªããœ
ãžãã³ããb.eããªãã»ãã³ã¯ã©ãâããã±ã«å
éã®ååšäžãã®é žäžåŒãŸãã¯ïŒ¡ã®ïŒâïŒãŸã
ã¯ïŒïŒâã·ã¢ãäžéäœãéæµããããšã«ãã€ãŠè£œ
é ãã察å¿ããïŒïŒ11âãžãããâ11âãªããœãž
ãã³ããb.eããªãã»ãã³âïŒâïŒãŸãã¯ïŒïŒâã«
ã«ãããµã«ããããåŸããã¢ã«ãããçæç©ã次
ã«ã¢ã³ã¢ãã¢ã§é£œåããã¢ã«ã³ãŒã«æ§æº¶åªäžãã
ã³å¡©åã¢ã³ã¢ããŠã ããã³æ°Žé žåã¢ã³ã¢ããŠã ã®
ååšäžã·ã¢ã³åãããªãŠã ã§åŠçããŠå¯Ÿå¿ããïŒ
âïŒãŸãã¯ïŒïŒâïŒïŒâã¢ããã¢ã»ããããªã«ïŒã«
転åãããåå¿ã¯é垞宀枩ã§è¡ãªãããå®çµã«ïŒ
ã16æéãå¿ èŠãšããããã®ããã«è£œé ããã¢ã
ãã¢ã»ããããªã«ãæ¿å¡©é žã§å®€æž©ã«ãããŠ20ã45
åéåŠçããŠå¯Ÿå¿ããïŒâïŒãŸãã¯ïŒïŒâïŒïŒâã¢
ããã¢ã»ãã¢ããïŒãåŸã次ã«ãžã¡ãã«ãã«ã ã¢
ããäžãäžå¡©åã€ãªãŠã§åŠçããŠåŒããã³ïŒ¡
ã®ææã®ïŒâïŒãŸãã¯ïŒïŒâïŒïŒâããããã·âïŒïŒ
ïŒïŒïŒâãã¢ãžã¢ãŸãŒã«âïŒâã€ã«ïŒâïŒïŒ11â
ãžãããâ11âãªããœãžãã³ããb.eããªãã»ã
ã³ãåŸãããã®åå¿é åºã¯æ¬¡ã®å³åŒã«å ·äœçã«ç€º
ããæçµçæç©ã®ïŒâããããã·âïŒïŒïŒïŒïŒâ
ãã¢ãžã¢ãŸãŒã«âïŒâã€ã«çœ®æåºã®äœçœ®ãé©åœãª
ïŒâïŒãŸãã¯ïŒïŒâã·ã¢ãåºçºç©è³ªã®éžæã«äŸåã
ãããšãç解ãããã
ïŒâäœã®çœ®æåºãïŒâããããã·âïŒâãããª
ã³âïŒïŒïŒâãžãªã³âïŒâã€ã«ã§ããæ¬çºæã®ã
ããã®ïŒïŒ11âãžãããâ11âãªããœãžãã³ã
ãb.eããªãã»ãã³ã¯æ¬¡ã®äžè¬åå¿å³åŒã«åŸã€ãŠè£œ
é ããããšãã§ããã
ã³âïŒïŒïŒâãžãªã³âïŒâã€ã«ã§ããæ¬çºæã®ã
ããã®ïŒïŒ11âãžãããâ11âãªããœãžãã³ã
ãb.eããªãã»ãã³ã¯æ¬¡ã®äžè¬åå¿å³åŒã«åŸã€ãŠè£œ
é ããããšãã§ããã
åŒäžãR2â²åã³R3â²ã¯ãããããR2ããã³R3ã®
å®çŸ©ãšåããã®ãæå³ãããé©åœã«çœ®æããã
R2â²ããã³ïŒãŸãã¯R3â²ãã¿ã©ã€ããïœâãããã
ã·ããšãã«é ¢é žã®ããããªãŠã å¡©ã§170ã250âã«
ãããŠïŒãïŒæéåŠçããŠå¯Ÿå¿ããïŒâïŒïŒâã«
ã«ããã·ãã³ãžã«ãªãã·ïŒããšãã«é ¢é žãåŸãã
ãšã«ãããé žãæ°Žæ§æ°Žé žåãããªãŠã å¡©ã§åŠç
ããæ··å液ãèžçºä¹ŸåºããŠïœâããããã·ããšã
ã«é ¢é žã®ããããªãŠã å¡©ãçæããããã¿ã©ã€ã
ã次ã«æ·»å ããåå¿ãäžèšã«èšèŒããéãå®æœã
ãããã®ããã«è£œé ããã«ã«ããã·ãã³ãžã«ãªã
ã·ããšãã«é ¢é žã70ã80âã§ïŒãïŒæéå§åãã³
äžããªãã«ãªãé ¢é žç¡æ°Žç©ãšæ¹æããããšã«ãã€
ãŠç°åãããäžéäœR2â²ããã³ïŒãŸãã¯R3â²çœ®æ
ïŒïŒ11âãžãããâ11âãªããœãžãã³ãŸãïœïŒ
ïœ ããªãã»ãã³âïŒâé ¢é žããªãã«ãªãé ¢é žæ··å
ç¡æ°Žç©ã次ã«å¡©åºã§åŠçããé žæ§åããŠéé¢é žã
åŸãã次ã«éé¢é žãå¡©åããªãã«æ¬¡ãã§ã¢ã³ã¢ã
ã¢ã§åŠçããŠã察å¿ããã¢ã»ãã¢ãããçæãã
ã«ãªãŠã ïœâããããµã€ãã®ååšäžãžã¡ãã«ãã«
ã ã¢ããäžãžãšãã«ãªããµã¬ãŒãã§åŠçããŠåŒ
ã®ææã®R2â²ããã³ïŒãŸãã¯R3â²çœ®æïŒâïŒïŒâã
ãããã·âÎ3âãããªã³âïŒïŒïŒâãžãªã³âïŒ
âã€ã«ïŒâïŒïŒ11âãžãããâ11âãªããœãžãã³
ããïœïŒïœ ããªãã»ãã³ãçæããã
å®çŸ©ãšåããã®ãæå³ãããé©åœã«çœ®æããã
R2â²ããã³ïŒãŸãã¯R3â²ãã¿ã©ã€ããïœâãããã
ã·ããšãã«é ¢é žã®ããããªãŠã å¡©ã§170ã250âã«
ãããŠïŒãïŒæéåŠçããŠå¯Ÿå¿ããïŒâïŒïŒâã«
ã«ããã·ãã³ãžã«ãªãã·ïŒããšãã«é ¢é žãåŸãã
ãšã«ãããé žãæ°Žæ§æ°Žé žåãããªãŠã å¡©ã§åŠç
ããæ··å液ãèžçºä¹ŸåºããŠïœâããããã·ããšã
ã«é ¢é žã®ããããªãŠã å¡©ãçæããããã¿ã©ã€ã
ã次ã«æ·»å ããåå¿ãäžèšã«èšèŒããéãå®æœã
ãããã®ããã«è£œé ããã«ã«ããã·ãã³ãžã«ãªã
ã·ããšãã«é ¢é žã70ã80âã§ïŒãïŒæéå§åãã³
äžããªãã«ãªãé ¢é žç¡æ°Žç©ãšæ¹æããããšã«ãã€
ãŠç°åãããäžéäœR2â²ããã³ïŒãŸãã¯R3â²çœ®æ
ïŒïŒ11âãžãããâ11âãªããœãžãã³ãŸãïœïŒ
ïœ ããªãã»ãã³âïŒâé ¢é žããªãã«ãªãé ¢é žæ··å
ç¡æ°Žç©ã次ã«å¡©åºã§åŠçããé žæ§åããŠéé¢é žã
åŸãã次ã«éé¢é žãå¡©åããªãã«æ¬¡ãã§ã¢ã³ã¢ã
ã¢ã§åŠçããŠã察å¿ããã¢ã»ãã¢ãããçæãã
ã«ãªãŠã ïœâããããµã€ãã®ååšäžãžã¡ãã«ãã«
ã ã¢ããäžãžãšãã«ãªããµã¬ãŒãã§åŠçããŠåŒ
ã®ææã®R2â²ããã³ïŒãŸãã¯R3â²çœ®æïŒâïŒïŒâã
ãããã·âÎ3âãããªã³âïŒïŒïŒâãžãªã³âïŒ
âã€ã«ïŒâïŒïŒ11âãžãããâ11âãªããœãžãã³
ããïœïŒïœ ããªãã»ãã³ãçæããã
ïŒâäœã®çœ®æåºãïŒâããããã·âÎ3âãã
ãªã³âïŒïŒïŒâãžãªã³âïŒâã€ã«ã§ããæ¬çºæã®
ïŒïŒ11âãžãããâ11âãªããœãžãã³ããïœïŒ
ïœ ããªãã»ãã³ã次ã®äžè¬åå¿å³åŒã«åŸã€ãŠè£œé
ããããšãã§ããã
ãªã³âïŒïŒïŒâãžãªã³âïŒâã€ã«ã§ããæ¬çºæã®
ïŒïŒ11âãžãããâ11âãªããœãžãã³ããïœïŒ
ïœ ããªãã»ãã³ã次ã®äžè¬åå¿å³åŒã«åŸã€ãŠè£œé
ããããšãã§ããã
åŒäžãR2â²åã³R3â²ã¯ãããããR2ããã³R3ã®
å®çŸ©ãšåããã®ãæå³ãããïŒâã¡ãã«ãã¿ã©ã€
ããé©åœã«çœ®æãããR2â²ããã³ïŒãŸãã¯R3â²çœ®æ
ãããªãŠã ããšãã¬ãŒãã§190ã230âã®æž©åºŠã«ã
ããŠ0.5ãïŒæéåŠçããããšã«ãã€ãŠã察å¿ã
ãïŒâããšããã·ã¡ãã«âïŒâã¡ãã«å®æ¯éŠé žã
åŸã次ã«å¡©åããªãã«ã§åŠçããå¡©åã¢ã³ã¢ããŠ
ã ã®ååšäžã§éåããŠã察å¿ããïŒâã¡ãã«â
ïŒïŒ11âãžãããâ11âãªããœãžãã³ãŸãïœïŒ
ïœ ããªãã»ãã³ãçæããã次ãã§ïŒâã¡ãã«èª
å°äœãèçŽ åãããã®ããã«è£œé ããããã¢ã¡ã
ã«ååç©ãã·ã¢ã³åãããªãŠã ã§åŠçããŠå¯Ÿå¿ã
ãïŒâã·ã¢ãã¡ãã«èªå°äœãçæããããã®äžé
äœã次ã«å¯Ÿå¿ããïŒâé ¢é žèªå°äœã«å æ°Žå解ãã
å¡©åããªãã«ã§æ¬¡ã«ã¢ã³ã¢ãã¢ã«ãã€ãŠåŠçããŠ
æ¢ã«èšèŒããæè¡ã«ãã€ãŠå¯Ÿå¿ããïŒâã¢ã»ãã¢
ããèªå°äœãçæããã次ãã§ã¢ã»ãã¢ãããã«
ãªãŠã ïœâããããµã€ãã®ååšäžããžã¡ãã«ãã«
ã ã¢ããäžãžãšãã«ãªããµã¬ãŒãã§åŠçããŠåŒ
ã®ææã®ïŒâïŒïŒâããããã·âÎ3âãããªã³
âïŒïŒïŒâãžãªã³âïŒâã€ã«ïŒâïŒïŒ11âãžãã
ãâ11âãªããœãžãã³ããïœïŒïœ ããªãã»ãã³ã
çæããã
å®çŸ©ãšåããã®ãæå³ãããïŒâã¡ãã«ãã¿ã©ã€
ããé©åœã«çœ®æãããR2â²ããã³ïŒãŸãã¯R3â²çœ®æ
ãããªãŠã ããšãã¬ãŒãã§190ã230âã®æž©åºŠã«ã
ããŠ0.5ãïŒæéåŠçããããšã«ãã€ãŠã察å¿ã
ãïŒâããšããã·ã¡ãã«âïŒâã¡ãã«å®æ¯éŠé žã
åŸã次ã«å¡©åããªãã«ã§åŠçããå¡©åã¢ã³ã¢ããŠ
ã ã®ååšäžã§éåããŠã察å¿ããïŒâã¡ãã«â
ïŒïŒ11âãžãããâ11âãªããœãžãã³ãŸãïœïŒ
ïœ ããªãã»ãã³ãçæããã次ãã§ïŒâã¡ãã«èª
å°äœãèçŽ åãããã®ããã«è£œé ããããã¢ã¡ã
ã«ååç©ãã·ã¢ã³åãããªãŠã ã§åŠçããŠå¯Ÿå¿ã
ãïŒâã·ã¢ãã¡ãã«èªå°äœãçæããããã®äžé
äœã次ã«å¯Ÿå¿ããïŒâé ¢é žèªå°äœã«å æ°Žå解ãã
å¡©åããªãã«ã§æ¬¡ã«ã¢ã³ã¢ãã¢ã«ãã€ãŠåŠçããŠ
æ¢ã«èšèŒããæè¡ã«ãã€ãŠå¯Ÿå¿ããïŒâã¢ã»ãã¢
ããèªå°äœãçæããã次ãã§ã¢ã»ãã¢ãããã«
ãªãŠã ïœâããããµã€ãã®ååšäžããžã¡ãã«ãã«
ã ã¢ããäžãžãšãã«ãªããµã¬ãŒãã§åŠçããŠåŒ
ã®ææã®ïŒâïŒïŒâããããã·âÎ3âãããªã³
âïŒïŒïŒâãžãªã³âïŒâã€ã«ïŒâïŒïŒ11âãžãã
ãâ11âãªããœãžãã³ããïœïŒïœ ããªãã»ãã³ã
çæããã
äžèšã§è¿°ã¹ããããªãããã®æ²»çç¹æ§ã®ä»ã«ã
æ¬çºæã®ïŒâïŒãŸãã¯ïŒïŒâã«ã«ãã³é žèªå°äœã¯åŒ
ããã³ïŒ¡ã®ä»ã®R1眮æïŒïŒ11âãžãããâ
11âãªããœãžãã³ããïœïŒïœ ããªãã»ãã³ã®è£œé
ã«ãããŠäŸ¡å€ã®ããäžéäœãšããŠåãããã®ãã
ã«ã«ã«ãã³é žãããªãã«ãã©ã€ãã奜ãŸããã¯å¡©
åããªãã«ã§åŠçããããšã«ãã€ãŠåŒïŒãŸãã¯
ïŒã®ïŒâïŒãŸãã¯ïŒïŒã«ã«ãã³é žã察å¿ãã
é žãã©ã€ãã奜ãŸããã¯é žã¯ãã©ã€ãã«å®¹æã«è»¢
åããããšãã§ãããçæããïŒâïŒãŸãã¯ïŒïŒâ
ããã«ã«ããã«âïŒïŒ11âãžãããâ11âãªããœ
ãžãã³ããïœïŒïœ ããªãã»ãã³ïŒå³ã¡ãåŒãŸã
ã¯ïŒ¡ã®ïŒâïŒãŸãã¯ïŒïŒâã¯ããã«ã«ããã«åå
ç©ïŒã次ã«çš®ã ã®ããç¥ãããŠããè©Šè¬ã§åŠçã
ãŠãææã®ãšã¹ãã«ããã³ã¢ããèªå°äœãçæã
ãããšãã§ããã
æ¬çºæã®ïŒâïŒãŸãã¯ïŒïŒâã«ã«ãã³é žèªå°äœã¯åŒ
ããã³ïŒ¡ã®ä»ã®R1眮æïŒïŒ11âãžãããâ
11âãªããœãžãã³ããïœïŒïœ ããªãã»ãã³ã®è£œé
ã«ãããŠäŸ¡å€ã®ããäžéäœãšããŠåãããã®ãã
ã«ã«ã«ãã³é žãããªãã«ãã©ã€ãã奜ãŸããã¯å¡©
åããªãã«ã§åŠçããããšã«ãã€ãŠåŒïŒãŸãã¯
ïŒã®ïŒâïŒãŸãã¯ïŒïŒã«ã«ãã³é žã察å¿ãã
é žãã©ã€ãã奜ãŸããã¯é žã¯ãã©ã€ãã«å®¹æã«è»¢
åããããšãã§ãããçæããïŒâïŒãŸãã¯ïŒïŒâ
ããã«ã«ããã«âïŒïŒ11âãžãããâ11âãªããœ
ãžãã³ããïœïŒïœ ããªãã»ãã³ïŒå³ã¡ãåŒãŸã
ã¯ïŒ¡ã®ïŒâïŒãŸãã¯ïŒïŒâã¯ããã«ã«ããã«åå
ç©ïŒã次ã«çš®ã ã®ããç¥ãããŠããè©Šè¬ã§åŠçã
ãŠãææã®ãšã¹ãã«ããã³ã¢ããèªå°äœãçæã
ãããšãã§ããã
åŸã€ãŠå
·äœçã«ã¯åŒããã³ïŒ¡ã®ã¯ãã«ã«ã«
ããã«ååç©ã (a) å ·äœäŸãšããŠã¡ã¿ããŒã«ããšã¿ããŒã«ãïŒâ
ãããããŒã«ããã¿ããŒã«ããã³ïŒâãã¿ããŒ
ã«ã®ãããªäœçŽã¢ã«ã«ããŒã«ã§åŠçããŠå¯Ÿå¿ã
ãäœçŽã¢ã«ãã«ãšã¹ãã«ãããã³ïŒ¡ãçæ
ããããšãã§ããã
ããã«ååç©ã (a) å ·äœäŸãšããŠã¡ã¿ããŒã«ããšã¿ããŒã«ãïŒâ
ãããããŒã«ããã¿ããŒã«ããã³ïŒâãã¿ããŒ
ã«ã®ãããªäœçŽã¢ã«ã«ããŒã«ã§åŠçããŠå¯Ÿå¿ã
ãäœçŽã¢ã«ãã«ãšã¹ãã«ãããã³ïŒ¡ãçæ
ããããšãã§ããã
(b) ã¢ã³ã¢ãã¢ã§åŠçããŠå¯Ÿå¿ããã«ã«ãããµã
ããããã³ïŒ¡ãçæããããšãã§ããã
ããããã³ïŒ¡ãçæããããšãã§ããã
(c) å
·äœäŸãšããŠã¡ãã«ã¢ãã³ããšãã«ã¢ãã³ã
ãããã«ã¢ãã³ãã€ãœãããã«ã¢ãã³ããã³ã
ãã«ã¢ãã³ã®ãããªïŒ®âäœçŽã¢ã«ãã«ã¢ãã³ãŸ
ãã¯å ·äœäŸãšããŠãžã¡ãã«ã¢ãã³ããžãšãã«ã¢
ãã³ããžãããã«ã¢ãã³ããã³ãžããã«ã¢ãã³
ã®ãããªïŒ®ïŒïŒ®âãžäœçŽã¢ã«ãã«ã¢ãã³ã§åŠç
ããŠå¯Ÿå¿ããâäœçŽã¢ã«ãã«ã«ã«ãããµãã
ãŸãã¯ïŒ¡ããŸãã¯ïŒ®ïŒïŒ®âãžäœçŽã¢ã«ãã«
ã«ã«ãããµãããXIãŸãã¯XIãçæããããš
ãã§ããã
ãããã«ã¢ãã³ãã€ãœãããã«ã¢ãã³ããã³ã
ãã«ã¢ãã³ã®ãããªïŒ®âäœçŽã¢ã«ãã«ã¢ãã³ãŸ
ãã¯å ·äœäŸãšããŠãžã¡ãã«ã¢ãã³ããžãšãã«ã¢
ãã³ããžãããã«ã¢ãã³ããã³ãžããã«ã¢ãã³
ã®ãããªïŒ®ïŒïŒ®âãžäœçŽã¢ã«ãã«ã¢ãã³ã§åŠç
ããŠå¯Ÿå¿ããâäœçŽã¢ã«ãã«ã«ã«ãããµãã
ãŸãã¯ïŒ¡ããŸãã¯ïŒ®ïŒïŒ®âãžäœçŽã¢ã«ãã«
ã«ã«ãããµãããXIãŸãã¯XIãçæããããš
ãã§ããã
(d) äœçŽã¢ã«ãã«ã¹ã«ãã³ã¢ããã§åŠçããŠå¯Ÿå¿
å¿ããâäœçŽã¢ã«ãã«ã¹ã«ããã«âã«ã«ãã
ãµã€ããXIIããã³XIIãçæããããšãã§ã
ãã
å¿ããâäœçŽã¢ã«ãã«ã¹ã«ããã«âã«ã«ãã
ãµã€ããXIIããã³XIIãçæããããšãã§ã
ãã
(e) ïŒâã€ããâïŒâã¡ãã«ãã¢ãŸãªãžã³ã§åŠç
ããŠå¯Ÿå¿ããïŒïŒâã¡ãã«âïŒâãã¢ãŸãªãžã
ãªãã³ïŒâã«ã«ãããµãããããã³ïŒ¡
ãçæããããšãã§ããã
ããŠå¯Ÿå¿ããïŒïŒâã¡ãã«âïŒâãã¢ãŸãªãžã
ãªãã³ïŒâã«ã«ãããµãããããã³ïŒ¡
ãçæããããšãã§ããã
(f) å
·äœäŸãšããŠãšãã¬ã³ã°ãªã³ãŒã«ãããªã¡ã
ã¬ã³ã°ãªã³ãŒã«ããã³ïŒâãã¿ã³ãžãªãŒã«ã®ã
ããªäœçŽã¢ã«ãã«ãžãªãŒã«ã§åŠçããŠã察å¿ã
ãããããã·äœçŽã¢ã«ãã«ãšã¹ãã«ããã
ã³ïŒ¡ãçæããããšãã§ããã
ã¬ã³ã°ãªã³ãŒã«ããã³ïŒâãã¿ã³ãžãªãŒã«ã®ã
ããªäœçŽã¢ã«ãã«ãžãªãŒã«ã§åŠçããŠã察å¿ã
ãããããã·äœçŽã¢ã«ãã«ãšã¹ãã«ããã
ã³ïŒ¡ãçæããããšãã§ããã
(g) å
·äœäŸãšããŠïŒ®ïŒïŒ®âãžã¡ãã«ãšã¿ããŒã«ã¢
ãã³ãïŒâïŒïŒ®ïŒïŒ®âãžã¡ãã«ã¢ããïŒããã
ã³âïŒâãªãŒã«ããã³ïŒâïŒïŒ®ïŒïŒ®âãžãšãã«
ã¢ããïŒãã¿ã³âïŒâãªãŒã«ã®ãããªïŒ®ïŒïŒ®â
ãžäœçŽã¢ã«ãã«ã¢ããäœçŽã¢ã«ã«ããŒã«ã§åŠç
ããŠå¯Ÿå¿ããïŒïŒ®âãžäœçŽã¢ã«ãã«ã¢ããäœ
çŽã¢ã«ãã«ãšã¹ãã«ããã³ïŒ¡ãçæã
ãããšãã§ããã
ãã³ãïŒâïŒïŒ®ïŒïŒ®âãžã¡ãã«ã¢ããïŒããã
ã³âïŒâãªãŒã«ããã³ïŒâïŒïŒ®ïŒïŒ®âãžãšãã«
ã¢ããïŒãã¿ã³âïŒâãªãŒã«ã®ãããªïŒ®ïŒïŒ®â
ãžäœçŽã¢ã«ãã«ã¢ããäœçŽã¢ã«ã«ããŒã«ã§åŠç
ããŠå¯Ÿå¿ããïŒïŒ®âãžäœçŽã¢ã«ãã«ã¢ããäœ
çŽã¢ã«ãã«ãšã¹ãã«ããã³ïŒ¡ãçæã
ãããšãã§ããã
(h) å
·äœäŸãšããŠã°ãªã·ã³ãã¢ã©ãã³ããã³ããª
ã³ã®ãããªã¢ããé žã§åŠçããŠå¯Ÿå¿ããâã«
ã«ããã·âäœçŽã¢ã«ãã«ã«ã«ãããµããã
ãã³ïŒ¡ãçæããããšãã§ããã
ã³ã®ãããªã¢ããé žã§åŠçããŠå¯Ÿå¿ããâã«
ã«ããã·âäœçŽã¢ã«ãã«ã«ã«ãããµããã
ãã³ïŒ¡ãçæããããšãã§ããã
(i) å
·äœäŸãšããŠããããã·é
¢é
žãïŒâãããã
ã·é ªé žããã³Î²âããããã·ããããªã³é žã®ã
ããªããããã·äœçŽã¢ã«ã«ã³é žã®ã¢ã«ã«ãªéå±
å¡©ã§åŠçããŠã察å¿ããã«ã«ããã·äœçŽã¢ã«ã
ã«ãšã¹ãã«ããã³ïŒ¡ãçæããããšã
ã§ããã
ã·é ªé žããã³Î²âããããã·ããããªã³é žã®ã
ããªããããã·äœçŽã¢ã«ã«ã³é žã®ã¢ã«ã«ãªéå±
å¡©ã§åŠçããŠã察å¿ããã«ã«ããã·äœçŽã¢ã«ã
ã«ãšã¹ãã«ããã³ïŒ¡ãçæããããšã
ã§ããã
R4ãããããã·ã§ãããR5ãæ°ŽçŽ ã§ããåŒ
ããã³ïŒ¡ã®ãããã®ïŒïŒ11âãžããããžãã³ã
ãïœïŒïœ ããªãã»ãã³ïŒäŸãã°ïŒïŒ11âãžããã
â11âããããã·ãžãã³ããïœïŒïœ ããªãã»ã
ã³ïŒã¯å¯Ÿå¿ãã11âãªããœååç©ïŒR1ïŒR2ãã
ã³R3ã¯åã«å®çŸ©ããéãã§ããïŒãéå å€ã§åŠ
çããããšã«ãã€ãŠå®¹æã«è£œé ããããšãã§ã
ããåŸã€ãŠå ·äœçã«ã¯åŒãŸãã¯ïŒ¡ã®ïŒâïŒãŸ
ãã¯ïŒïŒâïŒ1Hâããã©ãŸãŒã«ïŒâã€ã«ïŒâïŒïŒ11
âãžãããâ11âãªããœãžãã³ããïœïŒïœ ããªã
ã»ãã³ããšã¿ããŒã«ã®ãããªé©åœãªææ©æº¶åªäžé
垞宀枩ã§ãããªãŠã ãããã€ãã©ã€ãã§åŠçãã
ããšãã§ãããåå¿æ··å液ãæ°Žã§åžéããé žæ§å
ããæãææã®ïŒâïŒãŸãã¯ïŒïŒâïŒ1Hâããã©ãŸ
ãŒã«âïŒâã€ã«ïŒâïŒïŒ11âãžãããâ11âãã
ããã·ãžãã³ããïœïŒïœ ããªãã»ãã³ïŒåŒ
ãŸãã¯ïŒ¡ïŒãåé¢ãããåæ§ã«åŒãŸãã¯
ã®ïŒâïŒãŸãã¯ïŒïŒã«ã«ãã³é žã奜ãŸããã¯
åŒãŸãã¯ïŒ¡ã®äœçŽã¢ã«ãã«ãšã¹ãã«ã®åœ¢æ
ã§ã察å¿ãã11âããããã·ååç©ã«éå ããã
ãšãã§ãããšã¹ãã«åºãå æ°Žå解ã«ãã€ãŠé€å»ã
ãŠåŒXIIãŸãã¯XIIã®ïŒïŒ11âãžãããâ
11âããããã·ãžãã³ããïœïŒïœ ããªãã»ãã³ïŒ
âïŒãŸãã¯ïŒïŒã«ã«ãã³é žãçæããããšãã§ã
ãããããã®åå¿ã¯æ¬¡ã®å³åŒã«å ·äœçã«ç€ºãã
ãã
ããã³ïŒ¡ã®ãããã®ïŒïŒ11âãžããããžãã³ã
ãïœïŒïœ ããªãã»ãã³ïŒäŸãã°ïŒïŒ11âãžããã
â11âããããã·ãžãã³ããïœïŒïœ ããªãã»ã
ã³ïŒã¯å¯Ÿå¿ãã11âãªããœååç©ïŒR1ïŒR2ãã
ã³R3ã¯åã«å®çŸ©ããéãã§ããïŒãéå å€ã§åŠ
çããããšã«ãã€ãŠå®¹æã«è£œé ããããšãã§ã
ããåŸã€ãŠå ·äœçã«ã¯åŒãŸãã¯ïŒ¡ã®ïŒâïŒãŸ
ãã¯ïŒïŒâïŒ1Hâããã©ãŸãŒã«ïŒâã€ã«ïŒâïŒïŒ11
âãžãããâ11âãªããœãžãã³ããïœïŒïœ ããªã
ã»ãã³ããšã¿ããŒã«ã®ãããªé©åœãªææ©æº¶åªäžé
垞宀枩ã§ãããªãŠã ãããã€ãã©ã€ãã§åŠçãã
ããšãã§ãããåå¿æ··å液ãæ°Žã§åžéããé žæ§å
ããæãææã®ïŒâïŒãŸãã¯ïŒïŒâïŒ1Hâããã©ãŸ
ãŒã«âïŒâã€ã«ïŒâïŒïŒ11âãžãããâ11âãã
ããã·ãžãã³ããïœïŒïœ ããªãã»ãã³ïŒåŒ
ãŸãã¯ïŒ¡ïŒãåé¢ãããåæ§ã«åŒãŸãã¯
ã®ïŒâïŒãŸãã¯ïŒïŒã«ã«ãã³é žã奜ãŸããã¯
åŒãŸãã¯ïŒ¡ã®äœçŽã¢ã«ãã«ãšã¹ãã«ã®åœ¢æ
ã§ã察å¿ãã11âããããã·ååç©ã«éå ããã
ãšãã§ãããšã¹ãã«åºãå æ°Žå解ã«ãã€ãŠé€å»ã
ãŠåŒXIIãŸãã¯XIIã®ïŒïŒ11âãžãããâ
11âããããã·ãžãã³ããïœïŒïœ ããªãã»ãã³ïŒ
âïŒãŸãã¯ïŒïŒã«ã«ãã³é žãçæããããšãã§ã
ãããããã®åå¿ã¯æ¬¡ã®å³åŒã«å ·äœçã«ç€ºãã
ãã
äžèšã§èšèŒããããã«éæµäžå¡©åããªãã«ã§åŠ
çããé補é ãããåŒããã³ïŒ¡ã®11âããã
ãã·ååç©ïŒR1ïŒR2ããã³R3ã¯åã«å®çŸ©ããé
ãã§ããïŒã¯å¯Ÿå¿ãã11âã¯ããååç©ã«å®¹æã«
転åãããæ¬çºæã®ä»ã®11â眮æååç©ã®è£œé ã«
察ããäžéäœãšããŠåãã11âã¯ããäžéäœã¯å
é¢ããããšãã§ãã次ã®è»¢åã«å¯Ÿããåºçºç©è³ªãš
ããŠããèªèº«äœ¿çšããããšãã§ãããããããªã
ããææãªãã°11âã¯ããäžéäœããã®äœçœ®ã®ãŸ
ãŸçæããããšãã§ããåé¢ããã«æ¬¡ã®åå¿ã«äœ¿
çšããããšãã§ããã
çããé補é ãããåŒããã³ïŒ¡ã®11âããã
ãã·ååç©ïŒR1ïŒR2ããã³R3ã¯åã«å®çŸ©ããé
ãã§ããïŒã¯å¯Ÿå¿ãã11âã¯ããååç©ã«å®¹æã«
転åãããæ¬çºæã®ä»ã®11â眮æååç©ã®è£œé ã«
察ããäžéäœãšããŠåãã11âã¯ããäžéäœã¯å
é¢ããããšãã§ãã次ã®è»¢åã«å¯Ÿããåºçºç©è³ªãš
ããŠããèªèº«äœ¿çšããããšãã§ãããããããªã
ããææãªãã°11âã¯ããäžéäœããã®äœçœ®ã®ãŸ
ãŸçæããããšãã§ããåé¢ããã«æ¬¡ã®åå¿ã«äœ¿
çšããããšãã§ããã
åŸã€ãŠå
·äœçã«ã¯åŒãŸãã¯ïŒ¡ã®ïŒâïŒãŸã
ã¯ïŒïŒâã«ã«ãã³é žã奜é©ã«ã¯åŒãŸïŒ¡ã®äœçŽ
ã¢ã«ãã«ãšã¹ãã«ã®åœ¢æ ã§ãå¡©åããªãã«ã§éæµ
ããŠå¯Ÿå¿ããïŒïŒ11âãžãããâ11âã¯ãããžã
ã³ããïœïŒïœ ããªãã»ãã³âïŒâïŒãŸãã¯ïŒïŒâäœ
çŽã¢ã«ãã«ã«ã«ããã·ã¬ãŒããçæããããšãã§
ãããåå¿ã¯éåžžïŒã20åã§å®çµããå¡©åããªã
ã«ãæ¡å»ããåŸãçæç©ïŒåŒãŸãã¯
ïŒãåŸãã
ã¯ïŒïŒâã«ã«ãã³é žã奜é©ã«ã¯åŒãŸïŒ¡ã®äœçŽ
ã¢ã«ãã«ãšã¹ãã«ã®åœ¢æ ã§ãå¡©åããªãã«ã§éæµ
ããŠå¯Ÿå¿ããïŒïŒ11âãžãããâ11âã¯ãããžã
ã³ããïœïŒïœ ããªãã»ãã³âïŒâïŒãŸãã¯ïŒïŒâäœ
çŽã¢ã«ãã«ã«ã«ããã·ã¬ãŒããçæããããšãã§
ãããåå¿ã¯éåžžïŒã20åã§å®çµããå¡©åããªã
ã«ãæ¡å»ããåŸãçæç©ïŒåŒãŸãã¯
ïŒãåŸãã
åŒããã³ïŒ¡ã®11âäœçŽã¢ã«ãã«ããªååç©
ïŒR1ïŒR2ããã³R3ã¯åã«å®çŸ©ããéãã§ããïŒã¯
ãããªãŠã å¡©ã®ãããªã¡ã¿ã³ã¹ã«ãã€ã³é žã¢ã«ã«
ãªéå±å¡©ã§ãžã¡ãã«ãã«ã ã¢ããäžå¯Ÿå¿ãã11â
ã¯ããäžéäœãåŠçããããšã«ãã€ãŠè£œé ããã
ãšãã§ãããçŽ10ïŒ éå°ã®å¡©ã䜿çšããåå¿ã¯å®€
æž©ã§é²è¡ãããéåžžçŽïŒãïŒæéãåå¿ãå®çµã
ãããã«å¿ èŠãšãããæ°Žã§åžéããåŸãçæç©ã
éã«ãã€ãŠååããéåžžã®åçµæ¶ã«ãã€ãŠç²Ÿè£œ
ããã
ïŒR1ïŒR2ããã³R3ã¯åã«å®çŸ©ããéãã§ããïŒã¯
ãããªãŠã å¡©ã®ãããªã¡ã¿ã³ã¹ã«ãã€ã³é žã¢ã«ã«
ãªéå±å¡©ã§ãžã¡ãã«ãã«ã ã¢ããäžå¯Ÿå¿ãã11â
ã¯ããäžéäœãåŠçããããšã«ãã€ãŠè£œé ããã
ãšãã§ãããçŽ10ïŒ éå°ã®å¡©ã䜿çšããåå¿ã¯å®€
æž©ã§é²è¡ãããéåžžçŽïŒãïŒæéãåå¿ãå®çµã
ãããã«å¿ èŠãšãããæ°Žã§åžéããåŸãçæç©ã
éã«ãã€ãŠååããéåžžã®åçµæ¶ã«ãã€ãŠç²Ÿè£œ
ããã
åŸã€ãŠå
·äœçã«ã¯åŒïŒžãŸãã¯ïŒžïŒ¡
ã®ïŒïŒ11âãžãããâ11âã¯ãããžãã³ããïœïŒ
ïœ ããªãã»ãã³ïŒâïŒãŸãã¯ïŒïŒâäœçŽã¢ã«ãã«ã«
ã«ããã·ã¬ãŒãããžã¡ãã«ãã«ã ã¢ããäžã¡ã¿ã³
ã¹ã«ãã€ã³é žãããªãŠã å¡©ã§åŠçããŠå¯Ÿå¿ãã
ïŒïŒ11âãžãããâ11âã¡ãã«ã¹ã«ããã«ãžãã³
ããïœïŒïœ ããªãã»ãã³ïŒâïŒãŸãã¯ïŒïŒâäœçŽã¢
ã«ãã«ã«ã«ããã·ã¬ãŒãïŒåŒãŸãã¯
ãåŸãããšãã§ããéåžžã®æè¡ã«ãã€ãŠå
æ°Žå解ããŠåŒãŸãã¯ïŒ¡ã®éé¢é ž
ãåŸãããšãã§ããã
ã®ïŒïŒ11âãžãããâ11âã¯ãããžãã³ããïœïŒ
ïœ ããªãã»ãã³ïŒâïŒãŸãã¯ïŒïŒâäœçŽã¢ã«ãã«ã«
ã«ããã·ã¬ãŒãããžã¡ãã«ãã«ã ã¢ããäžã¡ã¿ã³
ã¹ã«ãã€ã³é žãããªãŠã å¡©ã§åŠçããŠå¯Ÿå¿ãã
ïŒïŒ11âãžãããâ11âã¡ãã«ã¹ã«ããã«ãžãã³
ããïœïŒïœ ããªãã»ãã³ïŒâïŒãŸãã¯ïŒïŒâäœçŽã¢
ã«ãã«ã«ã«ããã·ã¬ãŒãïŒåŒãŸãã¯
ãåŸãããšãã§ããéåžžã®æè¡ã«ãã€ãŠå
æ°Žå解ããŠåŒãŸãã¯ïŒ¡ã®éé¢é ž
ãåŸãããšãã§ããã
åŒããã³ïŒ¡ã®11âäœçŽã¢ã«ãã«ããªååç©
ïŒR1ïŒR2ïŒR3ã¯åã«å®çŸ©ããéãã§ããïŒã®è£œé
ãäœçŽã¢ã«ãã«ããªãŒã«ã§ãžã¡ãã«ãã«ã ã¢ãã
äžå¯Ÿå¿ãã11âã¯ããäžéäœãåŠçããããšã«ã
ã€ãŠéæãããåå¿ã¯éäŸå®€æž©ã§é²è¡ããéåžžå®
çµã«ïŒãïŒæéãå¿ èŠãšãããçæç©ããšãŒãã«
ã«æœåºãå¡©åºã§æŽæµã也ç¥ããã³èžçºä¹Ÿåºã«ãã€
ãŠååããã
ïŒR1ïŒR2ïŒR3ã¯åã«å®çŸ©ããéãã§ããïŒã®è£œé
ãäœçŽã¢ã«ãã«ããªãŒã«ã§ãžã¡ãã«ãã«ã ã¢ãã
äžå¯Ÿå¿ãã11âã¯ããäžéäœãåŠçããããšã«ã
ã€ãŠéæãããåå¿ã¯éäŸå®€æž©ã§é²è¡ããéåžžå®
çµã«ïŒãïŒæéãå¿ èŠãšãããçæç©ããšãŒãã«
ã«æœåºãå¡©åºã§æŽæµã也ç¥ããã³èžçºä¹Ÿåºã«ãã€
ãŠååããã
åŸã€ãŠå
·äœçã«ã¯åŒãŸãã¯ïŒ¡
ã®ïŒïŒ11âãžãããâ11âã¯ãããžãã³ããïœïŒ
ïœ ããªãã»ãã³âïŒâïŒãŸãã¯ïŒïŒâäœçŽã¢ã«ãã«
ã«ã«ããã·ã¬ãŒãã也ç¥ãžã¡ãã«ãã«ã ã¢ãã溶
液äžã¡ã¿ã³ããªãŒã«ã§å®€æž©ã«ãããŠåŠçããŠåŒ
ãŸãã¯ïŒ¡ã®å¯Ÿå¿ããïŒïŒ11âãžã
ããâ11âã¡ãã«ããªãžãã³ããïœïŒïœ ããªãã»
ãã³âïŒâïŒãŸãã¯ïŒïŒâäœçŽã¢ã«ãã«ã«ã«ããã·
ã¬ãŒããåŸãããšãã§ãããéäŸã®å æ°Žå解ã«ã
ã€ãŠãšã¹ãã«ãåŒãŸãã¯ïŒ¡ã®é
é¢é žã«è»¢åããããšãã§ããã
ã®ïŒïŒ11âãžãããâ11âã¯ãããžãã³ããïœïŒ
ïœ ããªãã»ãã³âïŒâïŒãŸãã¯ïŒïŒâäœçŽã¢ã«ãã«
ã«ã«ããã·ã¬ãŒãã也ç¥ãžã¡ãã«ãã«ã ã¢ãã溶
液äžã¡ã¿ã³ããªãŒã«ã§å®€æž©ã«ãããŠåŠçããŠåŒ
ãŸãã¯ïŒ¡ã®å¯Ÿå¿ããïŒïŒ11âãžã
ããâ11âã¡ãã«ããªãžãã³ããïœïŒïœ ããªãã»
ãã³âïŒâïŒãŸãã¯ïŒïŒâäœçŽã¢ã«ãã«ã«ã«ããã·
ã¬ãŒããåŸãããšãã§ãããéäŸã®å æ°Žå解ã«ã
ã€ãŠãšã¹ãã«ãåŒãŸãã¯ïŒ¡ã®é
é¢é žã«è»¢åããããšãã§ããã
11âã¢ãªãŒã«ããªèªå°äœãææããå Žåãåè¿°
ã®åå¿ã«ãããŠäœ¿çšããäœçŽã¢ã«ãã«ããªãŒã«ã
ã¢ãªãŒã«ããªãŒã«ã«çœ®ãæããã ããå¿ èŠãšã
ããåŸã€ãŠå ·äœçã«ã¯äžèšã§äœ¿çšããäœçŽã¢ã«ã
ã«ããªãŒã«ãå ·äœçã«ã¯ãªã«ãâãã¡ã¿âãŸãã¯
ãã©âäœçŽã¢ã«ãã«ããããããããã·ãäœçŽã¢
ã«ãã«ããªãŸãã¯ããªãã«ãªãã¡ãã«ããšãã«ã
ãªãŒã«ã®ãããªããšãã«ããªãŒã«ãŸãã¯ç°çœ®æã
ãšãã«ããªãŒã«ã«çœ®ãæããããšã«ãã€ãŠå¯Ÿå¿ã
ã11âããšãã«ããª11â眮æããšãã«ããªååç©
ãåŸãã
ã®åå¿ã«ãããŠäœ¿çšããäœçŽã¢ã«ãã«ããªãŒã«ã
ã¢ãªãŒã«ããªãŒã«ã«çœ®ãæããã ããå¿ èŠãšã
ããåŸã€ãŠå ·äœçã«ã¯äžèšã§äœ¿çšããäœçŽã¢ã«ã
ã«ããªãŒã«ãå ·äœçã«ã¯ãªã«ãâãã¡ã¿âãŸãã¯
ãã©âäœçŽã¢ã«ãã«ããããããããã·ãäœçŽã¢
ã«ãã«ããªãŸãã¯ããªãã«ãªãã¡ãã«ããšãã«ã
ãªãŒã«ã®ãããªããšãã«ããªãŒã«ãŸãã¯ç°çœ®æã
ãšãã«ããªãŒã«ã«çœ®ãæããããšã«ãã€ãŠå¯Ÿå¿ã
ã11âããšãã«ããª11â眮æããšãã«ããªååç©
ãåŸãã
äžèšã§èšèŒãã11âäœçŽã¢ã«ãã«ããªååç©ã®
é žåã¯åŒãŸãã¯ïŒ¡ã®å¯Ÿå¿ãã11âäœçŽã¢ã«ã
ã«ã¹ã«ãã€ãã«èªå°äœïŒR1ããã³R3ã¯äžèšã§èš
èŒããéãã§ããïŒãçããã11âäœçŽã¢ã«ãã«
ããªååç©ã¯é ¢é žã®ãããªé žæ§æº¶åªã®ååšäžéé ž
åæ°ŽçŽ ã§ãŸãã¯å ·äœäŸãšããŠïœâã¯ããéå®æ¯éŠ
é žãªã©ãå å«ããããŒãªãã·é žã®ãããªææ©ããŒ
ãªããµã€ãã§é žåããããšãã§ãããéå å€ã«å¯Ÿ
ããé žåå€ã®ïŒïŒïŒã¢ã«æ¯ã¯ææã®äœçŽã¢ã«ãã«
ã¹ã«ãã€ãã«ååç©ã補é ãããå ·äœçã«ã¯é ¢é ž
溶液äžåŒããã³ïŒ¡ã®ïŒïŒ11âãž
ãããâ11âã¡ãã«ããªãžãã³ããïœïŒïœ ããªã
ã»ãã³âïŒâïŒãŸãã¯ïŒïŒã«ã«ãã³é žã30ïŒ éé ž
åæ°ŽçŽ ã§åŠçããŠåŒããã³ïŒ¡ã®
察å¿ããïŒïŒ11âãžãããâ11âã¡ãã«ã¹ã«ãã€
ãã«ãžãã³ããïœïŒïœ ããªãã»ãã³âïŒâã«ã«ã
ã³é žãåŸãããšãã§ããã
é žåã¯åŒãŸãã¯ïŒ¡ã®å¯Ÿå¿ãã11âäœçŽã¢ã«ã
ã«ã¹ã«ãã€ãã«èªå°äœïŒR1ããã³R3ã¯äžèšã§èš
èŒããéãã§ããïŒãçããã11âäœçŽã¢ã«ãã«
ããªååç©ã¯é ¢é žã®ãããªé žæ§æº¶åªã®ååšäžéé ž
åæ°ŽçŽ ã§ãŸãã¯å ·äœäŸãšããŠïœâã¯ããéå®æ¯éŠ
é žãªã©ãå å«ããããŒãªãã·é žã®ãããªææ©ããŒ
ãªããµã€ãã§é žåããããšãã§ãããéå å€ã«å¯Ÿ
ããé žåå€ã®ïŒïŒïŒã¢ã«æ¯ã¯ææã®äœçŽã¢ã«ãã«
ã¹ã«ãã€ãã«ååç©ã補é ãããå ·äœçã«ã¯é ¢é ž
溶液äžåŒããã³ïŒ¡ã®ïŒïŒ11âãž
ãããâ11âã¡ãã«ããªãžãã³ããïœïŒïœ ããªã
ã»ãã³âïŒâïŒãŸãã¯ïŒïŒã«ã«ãã³é žã30ïŒ éé ž
åæ°ŽçŽ ã§åŠçããŠåŒããã³ïŒ¡ã®
察å¿ããïŒïŒ11âãžãããâ11âã¡ãã«ã¹ã«ãã€
ãã«ãžãã³ããïœïŒïœ ããªãã»ãã³âïŒâã«ã«ã
ã³é žãåŸãããšãã§ããã
åæ§ãªæ¹æ³ã§åŒããã³ïŒ¡ã®11âã¯ããäžé
äœïŒR1ïŒR2ããã³R3ã¯åã«å®çŸ©ããéãã§ããïŒ
ãã¡ã¿ã³ããªãŒã«ã«ãªãŠã å¡©ïŒã«ãªãŠã tertâã
ãããµã€ãããã³ã¡ã¿ã³ããªãŒã«ãããã®äœçœ®ã§
çæãããïŒã§ãã«ãªãŠã tertâããããµã€ãã®
ååšäžãå ·äœäŸãšããŠã¡ã¿ããŒã«ããšã¿ããŒã«ã
ãããããŒã«ãã€ãœãããããŒã«ãïœâãã¿ããŒ
ã«ãªã©ã®ãããªäœçŽã¢ã«ã«ããŒã«ã§ããã³ã€ãã
ãŸãŒã«ã§åŠçããŠåã åŒããã³ïŒ¡ã®å¯Ÿå¿ãã
11âæªçœ®æïŒR4ããã³R5ã¯æ°ŽçŽ ã§ããïŒã11âäœ
çŽã¢ã«ã³ãã·ããã³11âã€ãããŸãªã«ååç©ãç
æããããšãã§ããã
äœïŒR1ïŒR2ããã³R3ã¯åã«å®çŸ©ããéãã§ããïŒ
ãã¡ã¿ã³ããªãŒã«ã«ãªãŠã å¡©ïŒã«ãªãŠã tertâã
ãããµã€ãããã³ã¡ã¿ã³ããªãŒã«ãããã®äœçœ®ã§
çæãããïŒã§ãã«ãªãŠã tertâããããµã€ãã®
ååšäžãå ·äœäŸãšããŠã¡ã¿ããŒã«ããšã¿ããŒã«ã
ãããããŒã«ãã€ãœãããããŒã«ãïœâãã¿ããŒ
ã«ãªã©ã®ãããªäœçŽã¢ã«ã«ããŒã«ã§ããã³ã€ãã
ãŸãŒã«ã§åŠçããŠåã åŒããã³ïŒ¡ã®å¯Ÿå¿ãã
11âæªçœ®æïŒR4ããã³R5ã¯æ°ŽçŽ ã§ããïŒã11âäœ
çŽã¢ã«ã³ãã·ããã³11âã€ãããŸãªã«ååç©ãç
æããããšãã§ããã
åŒããã³ïŒ¡ã®11âã¯ããäžéäœïŒR1ïŒR2
ããã³R3ã¯åã«å®çŸ©ããéãã§ããïŒããŸãã
ã«ã ã¢ããã§åŠçããŠå¯Ÿå¿ãã11âãã«ã ã¢ãã
ååç©ãåŸãããšãã§ãã次ã«éäŸã®å æ°Žå解ã«
å§ããŠå¯Ÿå¿ãã11âã¢ããååç©ãåŸãããšãã§
ãããåŸã€ãŠå ·äœçã«ã¯åŒãŸãã¯
ã®ïŒïŒ11âãžãããâ11âã¯ãããžãã³ã
ãïœïŒïœ ããªãã»ãã³âïŒâïŒãŸãã¯ïŒïŒâäœçŽã¢
ã«ãã«ã«ã«ããã·ã¬ãŒãããã«ã ã¢ãããš100ã
120âã§ïŒãïŒæéå ç±ããå·åŽããæ°Žã§åžéãã
éããŠåŒããã³ïŒ¡ã®å¯Ÿå¿ãã
ïŒïŒ11âãžãããâ11âãã«ã ã¢ãããžãã³ã
ãïœïŒïœ ããªãã»ãã³âïŒâïŒãŸãã¯ïŒïŒâäœçŽã¢
ã«ãã«ã«ã«ããã·ã¬ãŒããåŸãããšãã§ãããæ
æããããããã®ååç©ã®é žå æ°Žå解ã¯11âã¢ã
ãååç©ãçæãããå æ°Žå解ãç·©ããªæ¡ä»¶äžã§
å®æœãããå ŽåïŒïŒã15ïŒ å¡©é žã®ãããªåžæ°Žæ§é ž
ããã³35ã50âã®ãããªäžåºžæž©åºŠïŒãå æ°Žå解ã¯
åŒïŒ¬ããã³LAã®å¯Ÿå¿ããïŒïŒ11âãžããã
â11âã¢ãããžãã³ããïœïŒïœ ããªãã»ãã³âïŒ
âïŒãŸãã¯ïŒïŒâäœçŽã¢ã«ãã«ã«ã«ããã·ã¬ãŒãã®
圢ã§çæãã11âãã«ã ã¢ããåºã§èµ·ããããã
ã«æ¿ããæ¡ä»¶äžã§ã¯ïŒæ¿å¡©é žã®ãããªæ¿çž®é žãã
ã³80ã100âã®ãããªããã«äžæãã枩床ïŒãå æ°Ž
å解ã¯åŒïŒ¬ããã³ïŒ¬ïŒ¡ã®å¯Ÿå¿ããïŒïŒ11
âãžãããâ11âã¢ãããžãã³ããïœïŒïœ ããªã
ã»ãã³âïŒâïŒãŸãã¯ïŒïŒã«ã«ãã³é žã®åœ¢ã§çæ
ãããã«ã ã¢ããåºããã³ãšã¹ãã«åºã®äž¡æ¹ã§èµ·
ãããéé¢ã¢ããé žã®ãã«ã ã¢ããåºã®åçã¯ã®
é žã®ååšäžéé¢ã¢ããé žãã®é žâé ¢é žç¡æ°Žç©ã§åŠ
çããããšã«ãã€ãŠå®¹æã«éæããåŒïŒ¬ãŸã
ã¯ïŒ¬ïŒ¡ã®å¯Ÿå¿ããïŒïŒ11âãžãããâ11âã
ã«ã ã¢ãããïœïŒïœ ããªãã»ãã³âïŒâïŒãŸãã¯
ïŒïŒâã«ã«ãã³é žã®åœ¢ã§çæããã
ããã³R3ã¯åã«å®çŸ©ããéãã§ããïŒããŸãã
ã«ã ã¢ããã§åŠçããŠå¯Ÿå¿ãã11âãã«ã ã¢ãã
ååç©ãåŸãããšãã§ãã次ã«éäŸã®å æ°Žå解ã«
å§ããŠå¯Ÿå¿ãã11âã¢ããååç©ãåŸãããšãã§
ãããåŸã€ãŠå ·äœçã«ã¯åŒãŸãã¯
ã®ïŒïŒ11âãžãããâ11âã¯ãããžãã³ã
ãïœïŒïœ ããªãã»ãã³âïŒâïŒãŸãã¯ïŒïŒâäœçŽã¢
ã«ãã«ã«ã«ããã·ã¬ãŒãããã«ã ã¢ãããš100ã
120âã§ïŒãïŒæéå ç±ããå·åŽããæ°Žã§åžéãã
éããŠåŒããã³ïŒ¡ã®å¯Ÿå¿ãã
ïŒïŒ11âãžãããâ11âãã«ã ã¢ãããžãã³ã
ãïœïŒïœ ããªãã»ãã³âïŒâïŒãŸãã¯ïŒïŒâäœçŽã¢
ã«ãã«ã«ã«ããã·ã¬ãŒããåŸãããšãã§ãããæ
æããããããã®ååç©ã®é žå æ°Žå解ã¯11âã¢ã
ãååç©ãçæãããå æ°Žå解ãç·©ããªæ¡ä»¶äžã§
å®æœãããå ŽåïŒïŒã15ïŒ å¡©é žã®ãããªåžæ°Žæ§é ž
ããã³35ã50âã®ãããªäžåºžæž©åºŠïŒãå æ°Žå解ã¯
åŒïŒ¬ããã³LAã®å¯Ÿå¿ããïŒïŒ11âãžããã
â11âã¢ãããžãã³ããïœïŒïœ ããªãã»ãã³âïŒ
âïŒãŸãã¯ïŒïŒâäœçŽã¢ã«ãã«ã«ã«ããã·ã¬ãŒãã®
圢ã§çæãã11âãã«ã ã¢ããåºã§èµ·ããããã
ã«æ¿ããæ¡ä»¶äžã§ã¯ïŒæ¿å¡©é žã®ãããªæ¿çž®é žãã
ã³80ã100âã®ãããªããã«äžæãã枩床ïŒãå æ°Ž
å解ã¯åŒïŒ¬ããã³ïŒ¬ïŒ¡ã®å¯Ÿå¿ããïŒïŒ11
âãžãããâ11âã¢ãããžãã³ããïœïŒïœ ããªã
ã»ãã³âïŒâïŒãŸãã¯ïŒïŒã«ã«ãã³é žã®åœ¢ã§çæ
ãããã«ã ã¢ããåºããã³ãšã¹ãã«åºã®äž¡æ¹ã§èµ·
ãããéé¢ã¢ããé žã®ãã«ã ã¢ããåºã®åçã¯ã®
é žã®ååšäžéé¢ã¢ããé žãã®é žâé ¢é žç¡æ°Žç©ã§åŠ
çããããšã«ãã€ãŠå®¹æã«éæããåŒïŒ¬ãŸã
ã¯ïŒ¬ïŒ¡ã®å¯Ÿå¿ããïŒïŒ11âãžãããâ11âã
ã«ã ã¢ãããïœïŒïœ ããªãã»ãã³âïŒâïŒãŸãã¯
ïŒïŒâã«ã«ãã³é žã®åœ¢ã§çæããã
åŒããã³ïœã®11âããããã·â11âäœçŽã¢
ã«ãã«ååç©ïŒR1ïŒR2ããã³R3ã¯åã«å®çŸ©ãã
éãã§ããïŒã¯å¯Ÿå¿ããïŒâïŒãŸãã¯ïŒïŒâã«ã«ã
ã³é žã奜ãŸããã¯äœçŽã¢ã«ãã«ãšã¹ãã«ã®åœ¢ã§ã
äŸãã°ã¡ãã«ãã°ãã·ãŠã ãšãŒãã€ãããšãã«ã
ã°ãã·ãŠã ãããã€ããã€ãœãããã«ãã°ãã·ãŠ
ã ãšãŒãã€ãããããã«ãã°ãã·ãŠã ãšãŒãã€
ããïœâããã«ãã°ãã·ãŠã ãããã€ããªã©ã®ã
ããªé©åœãªã°ãªãã€ãŒã«è©Šè¬ã§åŠçããçæäœçŽ
ã¢ã«ãã«ã«ã«ããã·ã¬ãŒããå æ°Žå解ããããšã«
ãã€ãŠè£œé ããŠéé¢é žãçæããããšãã§ããã
åŸã€ãŠå ·äœçã«ã¯åŒãŸãã¯ïŒ¡ã®ïŒïŒ11âãžã
ããâ11âãªããœãžãã³ããïœïŒïœ ãïŒâïŒãŸã
ã¯ïŒïŒâäœçŽã¢ã«ãã«ã«ã«ããã·ã¬ãŒããã¡ãã«
ãã°ãã·ãŠã ãšãŒãã€ãã§åŠçããŠåŒïŒ¬ãŸã
ã¯ïŒ¬ïŒ¡ã®å¯Ÿå¿ããïŒïŒ11âãžãããâ11âã
ãããã·âäœçŽã¢ã«ãã«ãžãã³ããïœïŒïœ ããªã
ã»ãã³âïŒâïŒãŸãã¯ïŒïŒâäœçŽã¢ã«ãã«ã«ã«ãã
ã·ã¬ãŒããçæãã次ã«åŒïŒ¬ãŸãã¯ïŒ¬ïŒ¡
ã®å¯Ÿå¿ããïŒâïŒãŸãã¯ïŒïŒâã«ã«ãã³é žãçæã
ãããšãã§ããã
ã«ãã«ååç©ïŒR1ïŒR2ããã³R3ã¯åã«å®çŸ©ãã
éãã§ããïŒã¯å¯Ÿå¿ããïŒâïŒãŸãã¯ïŒïŒâã«ã«ã
ã³é žã奜ãŸããã¯äœçŽã¢ã«ãã«ãšã¹ãã«ã®åœ¢ã§ã
äŸãã°ã¡ãã«ãã°ãã·ãŠã ãšãŒãã€ãããšãã«ã
ã°ãã·ãŠã ãããã€ããã€ãœãããã«ãã°ãã·ãŠ
ã ãšãŒãã€ãããããã«ãã°ãã·ãŠã ãšãŒãã€
ããïœâããã«ãã°ãã·ãŠã ãããã€ããªã©ã®ã
ããªé©åœãªã°ãªãã€ãŒã«è©Šè¬ã§åŠçããçæäœçŽ
ã¢ã«ãã«ã«ã«ããã·ã¬ãŒããå æ°Žå解ããããšã«
ãã€ãŠè£œé ããŠéé¢é žãçæããããšãã§ããã
åŸã€ãŠå ·äœçã«ã¯åŒãŸãã¯ïŒ¡ã®ïŒïŒ11âãžã
ããâ11âãªããœãžãã³ããïœïŒïœ ãïŒâïŒãŸã
ã¯ïŒïŒâäœçŽã¢ã«ãã«ã«ã«ããã·ã¬ãŒããã¡ãã«
ãã°ãã·ãŠã ãšãŒãã€ãã§åŠçããŠåŒïŒ¬ãŸã
ã¯ïŒ¬ïŒ¡ã®å¯Ÿå¿ããïŒïŒ11âãžãããâ11âã
ãããã·âäœçŽã¢ã«ãã«ãžãã³ããïœïŒïœ ããªã
ã»ãã³âïŒâïŒãŸãã¯ïŒïŒâäœçŽã¢ã«ãã«ã«ã«ãã
ã·ã¬ãŒããçæãã次ã«åŒïŒ¬ãŸãã¯ïŒ¬ïŒ¡
ã®å¯Ÿå¿ããïŒâïŒãŸãã¯ïŒïŒâã«ã«ãã³é žãçæã
ãããšãã§ããã
äžèšã§è£œé ãããããª11âããããã·â11âäœ
çŽã¢ã«ãã«âïŒïŒãŸãã¯ïŒïŒâäœçŽã¢ã«ãã«ã«ã«ã
ãã·ã¬ãŒããïœâãã«ãšã³ã¹ã«ãã³é žã®ååšäžã
ã³ãŒã³ãšå ç±ããŠåŒãŸãã¯ïœã®å¯Ÿå¿ãã11â
ã¢ã«ããªãã³âïŒâïŒãŸãã¯ïŒïŒâäœçŽã¢ã«ãã«ã«
ã«ããã·ã¬ãŒããçæããå æ°Žå解ã®éã察å¿ã
ãéé¢é žãçæããããšãã§ãããéé¢é žã®éå
ã¯å¯Ÿå¿ãã11âã¡ãã«ååç©ãçæãããåŸã€ãŠ
å ·äœçã«ã¯åŒïŒ¬ãŸãã¯ïŒ¬ïŒ¡ã®ïŒïŒ11âãž
ãããâ11âããããã·â11âã¡ãã«ãžãã³ã
ãïœïŒïœ ããªãã»ãã³âïŒâïŒãŸãã¯ïŒïŒâäœçŽã¢
ã«ãã«ã«ã«ããã·ã¬ãŒããïœâãã«ãšã³ã¹ã«ãã³
é žã®ååšäžãã³ãŒã³ãšå ç±ããŠåŒïŒ¬ãŸãã¯
ã®å¯Ÿå¿ãã11âã¡ãã¬ã³èªå°äœãçæãã
ããšãã§ããå æ°Žå解ããŠåŒïŒ¬ãŸãã¯ïŒ¬
ã®éé¢é žãçæããããšãã§ããããŠæ¬¡ã«è§Šåª
äœçšã§éå ããåŒïŒ¬ããã³ïŒ¬ïŒ¡ã®å¯Ÿå¿ã
ã11âã¡ãã«èªå°äœãçæããããšãã§ããã
çŽã¢ã«ãã«âïŒïŒãŸãã¯ïŒïŒâäœçŽã¢ã«ãã«ã«ã«ã
ãã·ã¬ãŒããïœâãã«ãšã³ã¹ã«ãã³é žã®ååšäžã
ã³ãŒã³ãšå ç±ããŠåŒãŸãã¯ïœã®å¯Ÿå¿ãã11â
ã¢ã«ããªãã³âïŒâïŒãŸãã¯ïŒïŒâäœçŽã¢ã«ãã«ã«
ã«ããã·ã¬ãŒããçæããå æ°Žå解ã®éã察å¿ã
ãéé¢é žãçæããããšãã§ãããéé¢é žã®éå
ã¯å¯Ÿå¿ãã11âã¡ãã«ååç©ãçæãããåŸã€ãŠ
å ·äœçã«ã¯åŒïŒ¬ãŸãã¯ïŒ¬ïŒ¡ã®ïŒïŒ11âãž
ãããâ11âããããã·â11âã¡ãã«ãžãã³ã
ãïœïŒïœ ããªãã»ãã³âïŒâïŒãŸãã¯ïŒïŒâäœçŽã¢
ã«ãã«ã«ã«ããã·ã¬ãŒããïœâãã«ãšã³ã¹ã«ãã³
é žã®ååšäžãã³ãŒã³ãšå ç±ããŠåŒïŒ¬ãŸãã¯
ã®å¯Ÿå¿ãã11âã¡ãã¬ã³èªå°äœãçæãã
ããšãã§ããå æ°Žå解ããŠåŒïŒ¬ãŸãã¯ïŒ¬
ã®éé¢é žãçæããããšãã§ããããŠæ¬¡ã«è§Šåª
äœçšã§éå ããåŒïŒ¬ããã³ïŒ¬ïŒ¡ã®å¯Ÿå¿ã
ã11âã¡ãã«èªå°äœãçæããããšãã§ããã
åŒããã³ïŒ¡ã®ä»ã®11âäœçŽã¢ã«ããªãã³å
åç©ïŒR1ïŒR2ããã³R3ã¯åã«å®çŸ©ããéãã§ã
ãïŒãtertã»ããã«ãªããŠã ã®ååšäžãäœçŽã¢ã«
ãã«ããªããšãã«ãã¹ãããŠã ãããã€ãã§åŒ
ãŸãã¯ïŒ¡ã®å¯Ÿå¿ããïŒâïŒãŸãã¯ïŒïŒâã·ã¢ãâ
ïŒïŒ11âãžãããâ11âãªããœãžãã³ããïœïŒ
ïœ ããªãã»ãã³ãåŠçããããšã«ãã€ãŠè£œé ãã
ããšãã§ããã次ã«ïŒâïŒãŸãã¯ïŒïŒâã·ã¢ãåºã
äžèšã«èšèŒããæ¹æ³ã«ãã€ãŠïŒïŒãŸãã¯ïŒïŒâã«ã«
ãã³é žãïŒâïŒãŸãã¯ïŒïŒâããã©ãŸãªã«ãŸãã¯ä»
ã®ææã®R1åºã«è»¢åããããšãã§ãããäœçŽã¢
ã«ãã«ããªããšãã«ãã¹ãããŠã ãããã€ããç°
眮æäœçŽã¢ã«ãã«ããšãã«ããªããšãã«ãã¹ãã
ãŠã ãããã€ãã«çœ®ãæããŠå¯Ÿå¿ãã11âããšã
ã«äœçŽã¢ã«ããªãã³ãŸãã¯11âç°çœ®æããšãã«äœ
çŽã¢ã«ããªãã³ååç©ã®åœ¢ãçæããã
åç©ïŒR1ïŒR2ããã³R3ã¯åã«å®çŸ©ããéãã§ã
ãïŒãtertã»ããã«ãªããŠã ã®ååšäžãäœçŽã¢ã«
ãã«ããªããšãã«ãã¹ãããŠã ãããã€ãã§åŒ
ãŸãã¯ïŒ¡ã®å¯Ÿå¿ããïŒâïŒãŸãã¯ïŒïŒâã·ã¢ãâ
ïŒïŒ11âãžãããâ11âãªããœãžãã³ããïœïŒ
ïœ ããªãã»ãã³ãåŠçããããšã«ãã€ãŠè£œé ãã
ããšãã§ããã次ã«ïŒâïŒãŸãã¯ïŒïŒâã·ã¢ãåºã
äžèšã«èšèŒããæ¹æ³ã«ãã€ãŠïŒïŒãŸãã¯ïŒïŒâã«ã«
ãã³é žãïŒâïŒãŸãã¯ïŒïŒâããã©ãŸãªã«ãŸãã¯ä»
ã®ææã®R1åºã«è»¢åããããšãã§ãããäœçŽã¢
ã«ãã«ããªããšãã«ãã¹ãããŠã ãããã€ããç°
眮æäœçŽã¢ã«ãã«ããšãã«ããªããšãã«ãã¹ãã
ãŠã ãããã€ãã«çœ®ãæããŠå¯Ÿå¿ãã11âããšã
ã«äœçŽã¢ã«ããªãã³ãŸãã¯11âç°çœ®æããšãã«äœ
çŽã¢ã«ããªãã³ååç©ã®åœ¢ãçæããã
äžèšã«ç¹ã«èšåããéããæ¬çºæã®æ°èŠãªãªã
ã»ãã³ã®å»è¬çã«äœ¿çšãåŸãå¡©ããŸãæ¬çºæã®ç¯
å²å ã«å å«ããããçšèªãå»è¬çã«äœ¿çšãåŸãå¡©
ã¯å»è¬çã«äœ¿çšãåŸãç¡æ¯æ§é žããèªå°ãããå¡©
ããã³å¡©åºãäŸãã°ã¢ã³ã¢ããŠã å¡©ããããªãŠã
ããã³ã«ãªãŠã å¡©ã®ãããªã¢ã«ã«ãªéå±å¡©ããã°
ãã·ãŠã ããã³ã«ã«ã·ãŠã å¡©ã®ãããªã¢ã«ã«ãªå
é¡éå±å¡©ãããªã¡ãã«ã¢ãã³ããžã¡ãã«ã¢ãã³ã
ãã³ããªãšã¿ããŒã«ã¢ãã³ã®ãããªã¢ãâããžã
ãã³ããªäœçŽã¢ã«ãã«ãŸãã¯äœçŽã¢ã«ã«ãã€ã«ã¢
ãã³ããèªå°ãããã¢ãã³å¡©ã®ãããªææ©å¡©åºã®
å¡©ããããªãžã³ãïŒâã¡ãã«ãããªãžã³ãããã©
ãžã³ããã³ã¢ã«ããªãªã³ã®ãããªè€çŽ ç°åŒã¢ãã³
ããèªå°ãããå¡©ãããã³å¡©é žãç¡«é žãé ç³é žã
ãã³ããããªã³é žã®ãããªå»è¬çã«äœ¿çšãåŸãé ž
ããèªå°ãããå¡©ãªã©ãå å«ããããšãæå³ã
ãã
ã»ãã³ã®å»è¬çã«äœ¿çšãåŸãå¡©ããŸãæ¬çºæã®ç¯
å²å ã«å å«ããããçšèªãå»è¬çã«äœ¿çšãåŸãå¡©
ã¯å»è¬çã«äœ¿çšãåŸãç¡æ¯æ§é žããèªå°ãããå¡©
ããã³å¡©åºãäŸãã°ã¢ã³ã¢ããŠã å¡©ããããªãŠã
ããã³ã«ãªãŠã å¡©ã®ãããªã¢ã«ã«ãªéå±å¡©ããã°
ãã·ãŠã ããã³ã«ã«ã·ãŠã å¡©ã®ãããªã¢ã«ã«ãªå
é¡éå±å¡©ãããªã¡ãã«ã¢ãã³ããžã¡ãã«ã¢ãã³ã
ãã³ããªãšã¿ããŒã«ã¢ãã³ã®ãããªã¢ãâããžã
ãã³ããªäœçŽã¢ã«ãã«ãŸãã¯äœçŽã¢ã«ã«ãã€ã«ã¢
ãã³ããèªå°ãããã¢ãã³å¡©ã®ãããªææ©å¡©åºã®
å¡©ããããªãžã³ãïŒâã¡ãã«ãããªãžã³ãããã©
ãžã³ããã³ã¢ã«ããªãªã³ã®ãããªè€çŽ ç°åŒã¢ãã³
ããèªå°ãããå¡©ãããã³å¡©é žãç¡«é žãé ç³é žã
ãã³ããããªã³é žã®ãããªå»è¬çã«äœ¿çšãåŸãé ž
ããèªå°ãããå¡©ãªã©ãå å«ããããšãæå³ã
ãã
åŒããã³ ã®ãªãã»ãã³ã¯PGF2ããŸãã¯ãã
ã¹ã¿ã°ã©ã³ãžã³çåæäžéäœã®ãããªé床ã®æãŸ
ãããªãåçž®äœçšãäžå ã§ãããããŸãã¯æž©è¡å
ç©ã®çŸç çç¶ã®æ²»çããã³äºé²ã«æçšã§ãããç¹
ã«åæ¯ã®ãããªã¢ã¬ã«ã®ãŒæ§çç¶ã®æ²»çããã³å¶
埡ã«äŸ¡å€ãããã
ã¹ã¿ã°ã©ã³ãžã³çåæäžéäœã®ãããªé床ã®æãŸ
ãããªãåçž®äœçšãäžå ã§ãããããŸãã¯æž©è¡å
ç©ã®çŸç çç¶ã®æ²»çããã³äºé²ã«æçšã§ãããç¹
ã«åæ¯ã®ãããªã¢ã¬ã«ã®ãŒæ§çç¶ã®æ²»çããã³å¶
埡ã«äŸ¡å€ãããã
åŒããã³ïŒ¡ã®ååç©ã®äºé²ãŸãã¯æ²»çæäž
éã®å€§ããã¯å¿è«æ²»çãããçç¶ã®æ§è³ªããã³é
ãã§ããã³åŒããã³ïŒ¡ã®ç¹å®ååç©ã§ããã³
æäžçµè·¯ã§å€åãããäžè¬ã«ïŒæ¥åœãã®æäžéç¯
å²ã¯äœéKgåœã0.2ã100mgã®ç¯å²å ã«ããã
éã®å€§ããã¯å¿è«æ²»çãããçç¶ã®æ§è³ªããã³é
ãã§ããã³åŒããã³ïŒ¡ã®ç¹å®ååç©ã§ããã³
æäžçµè·¯ã§å€åãããäžè¬ã«ïŒæ¥åœãã®æäžéç¯
å²ã¯äœéKgåœã0.2ã100mgã®ç¯å²å ã«ããã
æ¬çºæã®å»è¬çµæç©ã¯æŽ»æ§æåãšããŠåŒãã
ã³ïŒ¡ã®ååç©ãããªããå»è¬çã«äœ¿çšãåŸãæ
äœããã³é©å®ä»ã®æ²»çæåãå«æããããšãã§ã
ããçµæç©ã¯ããããæè¬ãããå Žåã«ãããŠæ
ãé©åœãªçµè·¯ã¯æ²»çãããçç¶ã®æ§è³ªããã³éã
ã«ãããŠæŽ»æ§æåã®æ§è³ªã«äŸåããããã©ãçµå£
çãçŽè žãçŒãèºã錻ãç®èãå±æãŸãã¯éçµå£
çïŒç®äžãçèå ããã³éèå ãå å«ããïŒæäž
ã«å¯ŸããŠé©åœãªçµæç©ãå å«ããããããã¯éäŸ
åäœäœ¿çšåœ¢æ ã§ååšããããšãã§ããå»è¬æè¡ã«
ãããŠããç¥ãããŠããããããæ¹æ³ã«ãã€ãŠèª¿
補ããããšãã§ããã
ã³ïŒ¡ã®ååç©ãããªããå»è¬çã«äœ¿çšãåŸãæ
äœããã³é©å®ä»ã®æ²»çæåãå«æããããšãã§ã
ããçµæç©ã¯ããããæè¬ãããå Žåã«ãããŠæ
ãé©åœãªçµè·¯ã¯æ²»çãããçç¶ã®æ§è³ªããã³éã
ã«ãããŠæŽ»æ§æåã®æ§è³ªã«äŸåããããã©ãçµå£
çãçŽè žãçŒãèºã錻ãç®èãå±æãŸãã¯éçµå£
çïŒç®äžãçèå ããã³éèå ãå å«ããïŒæäž
ã«å¯ŸããŠé©åœãªçµæç©ãå å«ããããããã¯éäŸ
åäœäœ¿çšåœ¢æ ã§ååšããããšãã§ããå»è¬æè¡ã«
ãããŠããç¥ãããŠããããããæ¹æ³ã«ãã€ãŠèª¿
補ããããšãã§ããã
éèå
æäžçšçµæç©ã䜿çšããçšéã«å¯ŸããŠã
é©åœãªïŒæ¥åœãã®äœ¿çšéç¯å²ã¯äœéïŒKgåœãåŒ
ããã³ ã®ååç©0.2ã25mgïŒå¥œãŸããã¯ïŒã15
mgïŒã§ãããçµå£æäžã䜿çšããå Žåã«ã¯é©åœãª
ïŒæ¥åœãã®äœ¿çšéç¯å²ã¯äœéïŒKgåœãåŒããã³
ã®ååç©çŽïŒã60mgã奜ãŸããã¯10ã40mgïŒ
Kgã§ããã
é©åœãªïŒæ¥åœãã®äœ¿çšéç¯å²ã¯äœéïŒKgåœãåŒ
ããã³ ã®ååç©0.2ã25mgïŒå¥œãŸããã¯ïŒã15
mgïŒã§ãããçµå£æäžã䜿çšããå Žåã«ã¯é©åœãª
ïŒæ¥åœãã®äœ¿çšéç¯å²ã¯äœéïŒKgåœãåŒããã³
ã®ååç©çŽïŒã60mgã奜ãŸããã¯10ã40mgïŒ
Kgã§ããã
åæ¯æ²»çã®å Žåã«çµå£æäžã«ããã³åžå
¥ã«é©åœ
ãªæ¬çºæã®å»è¬çµæç©ã¯åã 掻æ§æåã®äºãå®é
ããéãå«æããã«ãã»ã«å€ãã«ã·ãšãŒå€ãŸãã¯
é å€ãæ£å€ãŸãã¯é¡ç²å€ããŸãã¯æ°Žæ§æ¶²äœãŸãã¯
éæ°Žæ§æ¶²äœäžã®æ¶²å€ãŸãã¯æžæ¿æ¶²å€ãæ°Žäžæ²¹åä¹³
å€ãŸãã¯æ²¹äžæ°Žå液äœä¹³å€ã®ãããªåã å¥ã ã®å
äœãšããŠååšããããšãã§ããããããçµæç©ã¯
å»è¬ã®ããããæ¹æ³ã«ãã€ãŠèª¿è£œããããšãã§ã
ãããã¹ãŠã®æ¹æ³ã¯ïŒçš®ãŸãã¯ãã以äžã®å¿ èŠãª
æåãæ§æããæ äœãšæŽ»æ§æåã䜵çšãã段éã
å å«ãããäžè¬ã«çµæç©ã¯æŽ»æ§æåã液äœæ äœãŸ
ãã¯åŸ®çŽ°åºäœæ äœãŸãã¯ãã®äž¡æ¹ãšå質ã«ãããŠ
å¯ã«æ··åããããšã«ãã€ãŠã次ã«å¿ èŠãªãã°çæ
ç©ãææã®åœ¢ã«ããããšã«ãã€ãŠèª¿è£œãããå ·äœ
çã«ã¯é å€ã¯é©å®ïŒçš®ãŸãã¯ãã以äžã®è£å©æå
ã§å§çž®ãŸãã¯æåããããšã«ãã€ãŠè£œé ããããš
ãã§ãããå§çž®é å€ã¯çµåå€ãæ»æ²¢å€ãäžæŽ»æ§åž
éå€ã最æ»å€ãçé¢æŽ»æ§å€ãŸãã¯åæ£å€ãšé©å®æ··
åããæ£å€ãŸãã¯é¡ç²å€ã®ãããªèªç±æµã圢æ ã®
掻æ§æåãé©åœãªæ©æ¢°ã§å§çž®ããããšã«ãã€ãŠè£œ
é ããããšãã§ãããæåé å€ã¯äžæŽ»æ§æ¶²äœåžé
å€ã§æ¹¿ãããç²æ«ååç©ã®æ··åç©ã®é©åœãªæ©æ¢°ã§
æåããããšã«ãã€ãŠè£œããããšãã§ãããæãŸ
ããã¯åé å€ã¯æŽ»æ§æå50ã500mgãå«æããå
ã«ã·ãšãŒå€ãŸãã¯ã«ãã»ã«å€ã¯æŽ»æ§æå50ã500
mgãå«æããã
ãªæ¬çºæã®å»è¬çµæç©ã¯åã 掻æ§æåã®äºãå®é
ããéãå«æããã«ãã»ã«å€ãã«ã·ãšãŒå€ãŸãã¯
é å€ãæ£å€ãŸãã¯é¡ç²å€ããŸãã¯æ°Žæ§æ¶²äœãŸãã¯
éæ°Žæ§æ¶²äœäžã®æ¶²å€ãŸãã¯æžæ¿æ¶²å€ãæ°Žäžæ²¹åä¹³
å€ãŸãã¯æ²¹äžæ°Žå液äœä¹³å€ã®ãããªåã å¥ã ã®å
äœãšããŠååšããããšãã§ããããããçµæç©ã¯
å»è¬ã®ããããæ¹æ³ã«ãã€ãŠèª¿è£œããããšãã§ã
ãããã¹ãŠã®æ¹æ³ã¯ïŒçš®ãŸãã¯ãã以äžã®å¿ èŠãª
æåãæ§æããæ äœãšæŽ»æ§æåã䜵çšãã段éã
å å«ãããäžè¬ã«çµæç©ã¯æŽ»æ§æåã液äœæ äœãŸ
ãã¯åŸ®çŽ°åºäœæ äœãŸãã¯ãã®äž¡æ¹ãšå質ã«ãããŠ
å¯ã«æ··åããããšã«ãã€ãŠã次ã«å¿ èŠãªãã°çæ
ç©ãææã®åœ¢ã«ããããšã«ãã€ãŠèª¿è£œãããå ·äœ
çã«ã¯é å€ã¯é©å®ïŒçš®ãŸãã¯ãã以äžã®è£å©æå
ã§å§çž®ãŸãã¯æåããããšã«ãã€ãŠè£œé ããããš
ãã§ãããå§çž®é å€ã¯çµåå€ãæ»æ²¢å€ãäžæŽ»æ§åž
éå€ã最æ»å€ãçé¢æŽ»æ§å€ãŸãã¯åæ£å€ãšé©å®æ··
åããæ£å€ãŸãã¯é¡ç²å€ã®ãããªèªç±æµã圢æ ã®
掻æ§æåãé©åœãªæ©æ¢°ã§å§çž®ããããšã«ãã€ãŠè£œ
é ããããšãã§ãããæåé å€ã¯äžæŽ»æ§æ¶²äœåžé
å€ã§æ¹¿ãããç²æ«ååç©ã®æ··åç©ã®é©åœãªæ©æ¢°ã§
æåããããšã«ãã€ãŠè£œããããšãã§ãããæãŸ
ããã¯åé å€ã¯æŽ»æ§æå50ã500mgãå«æããå
ã«ã·ãšãŒå€ãŸãã¯ã«ãã»ã«å€ã¯æŽ»æ§æå50ã500
mgãå«æããã
æ¬çºæãå®æœããããã«åºé¡äººã«ãã€ãŠäŒå³ã
ããæè¯ã®æ¹æ³ã¯æ¬¡ã®äœæ¥å®æœäŸã§å ·äœçã«èª¬æ
ãããããããªããæ·»ä»ãããç¹èš±è«æ±ã®ç¯å²ã§
è¿°ã¹ãããã«ãããã«éå®ããããã®ã§ã¯ãªãã
ããæè¯ã®æ¹æ³ã¯æ¬¡ã®äœæ¥å®æœäŸã§å ·äœçã«èª¬æ
ãããããããªããæ·»ä»ãããç¹èš±è«æ±ã®ç¯å²ã§
è¿°ã¹ãããã«ãããã«éå®ããããã®ã§ã¯ãªãã
ãªããå®æœäŸïŒãïŒãïŒã14ã16ã19ã23ã
26ã29ã31ã34ããã³38ã¯åèã®ããã®äŸã§ã
ãã
26ã29ã31ã34ããã³38ã¯åèã®ããã®äŸã§ã
ãã
å®æœäŸ ïŒ
ïŒïŒ11âãžãããâ11âãªããœãžãã³ãºãïœïŒ
ïœ ããªãã»ãã³âïŒâã«ã«ãã³é ž å·¥çšïŒ¡ïŒã¡ãã«Î±âããã¢âïœâãã«ãšãŒã 41ïœïŒ0.3ã¢ã«ïŒã®ïœâãã«ã€ã«é žåã³100c.c.ã®
å¡©åããªãã«ã®æ··åç©ã60ã70âã§ïŒæéå ç±ã
ããéå°ã®å¡©åããªãã«ããã³ãŒã³ãšå ±çå»ãã
ããæ®æž£ïŒé žã¯ãã©ã€ãïŒã60c.c.ã®ãã³ãŒã³ã«æº¶
解ãããã®æº¶æ¶²ãè¿ éãªæ»Žäžé床300c.c.ã®ã¡ã¿ã
ãŒã«ã«æ·»å ãããæ··åç©ãïŒæéæ¹æåŸã溶åªã
çå»ãããæ®æž£ïŒã¡ãã«ãšã¹ãã«ïŒã500c.c.ã®å
å¡©åççŽ ã«æº¶è§£ããã59ïœã®ïŒ®âããã¢ãµã¯ã·ã
ããïŒ10ïŒ éå°ãæ·»å ããŠïŒæééæµããããæ··
åç©ãå·åŽããéãã液ãã溶åªãé€å»ããŠ
é»è²æ²¹ã«ããããã®ç²è£œã¡ãã«Î±âããã¢âïœâ
ãã«ãšãŒãïŒ68ïœïŒãæŽã«ç²Ÿè£œããããšãªã次ã®
å·¥çšã«äœ¿çšããã
ïœ ããªãã»ãã³âïŒâã«ã«ãã³é ž å·¥çšïŒ¡ïŒã¡ãã«Î±âããã¢âïœâãã«ãšãŒã 41ïœïŒ0.3ã¢ã«ïŒã®ïœâãã«ã€ã«é žåã³100c.c.ã®
å¡©åããªãã«ã®æ··åç©ã60ã70âã§ïŒæéå ç±ã
ããéå°ã®å¡©åããªãã«ããã³ãŒã³ãšå ±çå»ãã
ããæ®æž£ïŒé žã¯ãã©ã€ãïŒã60c.c.ã®ãã³ãŒã³ã«æº¶
解ãããã®æº¶æ¶²ãè¿ éãªæ»Žäžé床300c.c.ã®ã¡ã¿ã
ãŒã«ã«æ·»å ãããæ··åç©ãïŒæéæ¹æåŸã溶åªã
çå»ãããæ®æž£ïŒã¡ãã«ãšã¹ãã«ïŒã500c.c.ã®å
å¡©åççŽ ã«æº¶è§£ããã59ïœã®ïŒ®âããã¢ãµã¯ã·ã
ããïŒ10ïŒ éå°ãæ·»å ããŠïŒæééæµããããæ··
åç©ãå·åŽããéãã液ãã溶åªãé€å»ããŠ
é»è²æ²¹ã«ããããã®ç²è£œã¡ãã«Î±âããã¢âïœâ
ãã«ãšãŒãïŒ68ïœïŒãæŽã«ç²Ÿè£œããããšãªã次ã®
å·¥çšã«äœ¿çšããã
å·¥çšïŒ¢ïŒïœâïŒïœâããã¢ããšããã·ã¡ãã«å®æ¯
éŠé žã¡ãã«ãšã¹ãã« 50ïŒ ã®æ²¹åæ£ç©ã®æ°Žé žåãããªãŠã 15.12ïœ
ïŒ0.315ã¢ã«ïŒããããµã³ã§æ²¹ããªããªããŸã§æŽæµ
ãã250c.c.ã®ïŒ®ïŒïŒ®âãžã¡ãã«ãã«ã ã¢ããäžã«
æžæ¿ãããã54.5ïœïŒ0.315ã¢ã«ïŒã®ïœâããã¢
ããšããŒã«ãæ°ŽçŽ ãçºçãããªããå°ããã€æ·»å
ãããã¬ã¹ã®çºçããããŸã€ãåŸãã¡ãã«Î±âã
ãã¢âïœâãã«ãšãŒã68ïœïŒ0.3ã¢ã«ïŒã®ïŒ®ïŒïŒ®
âãžã¡ãã«ãã«ã ã¢ãã50c.c.溶液ãè¿ éãªæ»Žäžé
床ã§æ·»å ãããæ··åç©ã45åéæ¹æããïŒã®å·
æ°Žäžã«æ³šå ¥ãããåºäœãéã«ããåé¢ããæ°ŽæŽ
也ç¥ãè¡ã90ïœã®ç²è£œïœâïŒïœâããã¢ããšãã
ã·ã¡ãã«ïŒå®æ¯éŠé žã¡ãã«ãšã¹ãã«ãåŸãããã
æŽã«ç²Ÿè£œããããšãªã次ã®å·¥çšã«çšããã
éŠé žã¡ãã«ãšã¹ãã« 50ïŒ ã®æ²¹åæ£ç©ã®æ°Žé žåãããªãŠã 15.12ïœ
ïŒ0.315ã¢ã«ïŒããããµã³ã§æ²¹ããªããªããŸã§æŽæµ
ãã250c.c.ã®ïŒ®ïŒïŒ®âãžã¡ãã«ãã«ã ã¢ããäžã«
æžæ¿ãããã54.5ïœïŒ0.315ã¢ã«ïŒã®ïœâããã¢
ããšããŒã«ãæ°ŽçŽ ãçºçãããªããå°ããã€æ·»å
ãããã¬ã¹ã®çºçããããŸã€ãåŸãã¡ãã«Î±âã
ãã¢âïœâãã«ãšãŒã68ïœïŒ0.3ã¢ã«ïŒã®ïŒ®ïŒïŒ®
âãžã¡ãã«ãã«ã ã¢ãã50c.c.溶液ãè¿ éãªæ»Žäžé
床ã§æ·»å ãããæ··åç©ã45åéæ¹æããïŒã®å·
æ°Žäžã«æ³šå ¥ãããåºäœãéã«ããåé¢ããæ°ŽæŽ
也ç¥ãè¡ã90ïœã®ç²è£œïœâïŒïœâããã¢ããšãã
ã·ã¡ãã«ïŒå®æ¯éŠé žã¡ãã«ãšã¹ãã«ãåŸãããã
æŽã«ç²Ÿè£œããããšãªã次ã®å·¥çšã«çšããã
å·¥çšïŒ£ïŒïœâïŒïœâããã¢ããšããã·ã¡ãã«ïŒå®
æ¯éŠé ž å·¥çšïŒ¢ããã®ç²è£œïœâïŒïœâããã¢ããšããã·
ã¡ãã«ïŒå®æ¯éŠé žã¡ãã«ãšã¹ãã«90ïœã500c.c.ã®
ã¡ã¿ããŒã«åã³250c.c.ã®10ïŒ æ°Žé žåãããªãŠã æ°Ž
溶液ã®æ··åç©ã§éæµããããã¡ã¿ããŒã«ãèžçºã
ããåŸããã氎溶液ãç容éã®æ°Žã§çšéãããæ¿
å¡©é žã§é žæ§ã«ãããåºäœãå¥ããæ°ŽæŽåŸç空也
ç¥ããŠç®ççæç©ãåŸãïŒèç¹183ã185âïŒã
æ¯éŠé ž å·¥çšïŒ¢ããã®ç²è£œïœâïŒïœâããã¢ããšããã·
ã¡ãã«ïŒå®æ¯éŠé žã¡ãã«ãšã¹ãã«90ïœã500c.c.ã®
ã¡ã¿ããŒã«åã³250c.c.ã®10ïŒ æ°Žé žåãããªãŠã æ°Ž
溶液ã®æ··åç©ã§éæµããããã¡ã¿ããŒã«ãèžçºã
ããåŸããã氎溶液ãç容éã®æ°Žã§çšéãããæ¿
å¡©é žã§é žæ§ã«ãããåºäœãå¥ããæ°ŽæŽåŸç空也
ç¥ããŠç®ççæç©ãåŸãïŒèç¹183ã185âïŒã
å·¥çšïŒ€ïŒïŒâããã¢âïŒïŒ11âãžãããâ11âãª
ããœãžãã³ãºãïœïŒïœ ãâãªãã»ãã³ 120ïœã®ïœâïŒïœâããã¢ããšããã·ã¡ãã«ïŒâ
å®æ¯éŠé žã0.5c.c.ã®äžããåããŠçŽ ïŒãšãŒãã«ïŒ
é¯äœãå«æããç¡æ°Žããªãã«ãªãé ¢é ž500c.c.äžã§
ïŒ 1/2æééæµããããå·åŽåŸåºäœãå¥ãããš
ãŒãã«ã§æŽæµããŠç®ççæç©ãåŸãïŒèç¹136ã
139âïŒã
ããœãžãã³ãºãïœïŒïœ ãâãªãã»ãã³ 120ïœã®ïœâïŒïœâããã¢ããšããã·ã¡ãã«ïŒâ
å®æ¯éŠé žã0.5c.c.ã®äžããåããŠçŽ ïŒãšãŒãã«ïŒ
é¯äœãå«æããç¡æ°Žããªãã«ãªãé ¢é ž500c.c.äžã§
ïŒ 1/2æééæµããããå·åŽåŸåºäœãå¥ãããš
ãŒãã«ã§æŽæµããŠç®ççæç©ãåŸãïŒèç¹136ã
139âïŒã
å·¥çšïŒ¥ïŒïŒâã·ã¢ãâïŒïŒ11âãžãããâ11âãª
ããœãžãã³ãºãïœïŒïœ ãâãªãã»ãã³ 43ïœïŒ0.1488ã¢ã«ã®ïŒâããã¢âïŒïŒ11âãžã
ããâ11âãªããœãžãã³ãºãïœïŒïœ ããªãã»ãã³
åã³16ïœã®ïŒ0.178ã¢ã«ïŒ20ïŒ éå°ïŒã®ã·ã¢ã³å
第äžé ã150c.c.ã®ïŒ®ïŒïŒ®âãžã¡ãã«ãã«ã ã¢ãã
äžã§24æééæµãããã100âã«å·åŽåŸæ¹æããª
ããå¡©å第äºé100ïœã®ïŒïŒ å¡©é žæ°Žæº¶æ¶²140c.c.ã®æº¶
液ã«æ³šå ãããæ··åç©ã70âã§30åéä¿ã¡ãå·
åŽãéãåºäœãæ°ŽæŽãããåºäœãå¡©åã¡ãã¬ã³
ã«æº¶è§£ãã·ãªã«ã²ã«ã®çãã«ã©ã ãéããŠé粟
補ããïŒèç¹160ã161âïŒã
ããœãžãã³ãºãïœïŒïœ ãâãªãã»ãã³ 43ïœïŒ0.1488ã¢ã«ã®ïŒâããã¢âïŒïŒ11âãžã
ããâ11âãªããœãžãã³ãºãïœïŒïœ ããªãã»ãã³
åã³16ïœã®ïŒ0.178ã¢ã«ïŒ20ïŒ éå°ïŒã®ã·ã¢ã³å
第äžé ã150c.c.ã®ïŒ®ïŒïŒ®âãžã¡ãã«ãã«ã ã¢ãã
äžã§24æééæµãããã100âã«å·åŽåŸæ¹æããª
ããå¡©å第äºé100ïœã®ïŒïŒ å¡©é žæ°Žæº¶æ¶²140c.c.ã®æº¶
液ã«æ³šå ãããæ··åç©ã70âã§30åéä¿ã¡ãå·
åŽãéãåºäœãæ°ŽæŽãããåºäœãå¡©åã¡ãã¬ã³
ã«æº¶è§£ãã·ãªã«ã²ã«ã®çãã«ã©ã ãéããŠé粟
補ããïŒèç¹160ã161âïŒã
å·¥çšïŒŠïŒïŒïŒ11âãžãããâ11âãªããœãžãã³ãº
ãïœïŒïœ ããªãã»ãã³âïŒâã«ã«ãã³é ž ïŒâã·ã¢ãâïŒïŒ11âãžãããâ11âãªããœãž
ãã³ãºãïœïŒïœ ããªãã»ãã³ã300c.c.ã®37ïŒ å¡©é ž
氎溶液åã³300c.c.ã®æ°·é ¢é žã®æ··åç©äžã§24æéé
æµããããå·åŽåŸæ°Žã§çšéãåºäœãå¥ããŠç®ç
çæç©ãåŸãïŒèç¹250âãå解ïŒã
ãïœïŒïœ ããªãã»ãã³âïŒâã«ã«ãã³é ž ïŒâã·ã¢ãâïŒïŒ11âãžãããâ11âãªããœãž
ãã³ãºãïœïŒïœ ããªãã»ãã³ã300c.c.ã®37ïŒ å¡©é ž
氎溶液åã³300c.c.ã®æ°·é ¢é žã®æ··åç©äžã§24æéé
æµããããå·åŽåŸæ°Žã§çšéãåºäœãå¥ããŠç®ç
çæç©ãåŸãïŒèç¹250âãå解ïŒã
å®æœäŸ ïŒ
ïŒïŒ11âãžãããâ11âãªããœãžãã³ãºãïœïŒ
ïœ ããªãã»ãã³âïŒâã«ã«ãã³é ž å·¥çšïŒ¡ïŒïŒâããã¢âïœâãã«ã€ã«é ž 140ïœïŒ0.875ã¢ã«ïŒã®èçŽ åã³2.45ïœã®éç²ã
氷济äžã§å·åŽã93.31ïœïŒ0.7ã¢ã«ïŒïœâãã«ã€ã«
é žã15åéã«ããã€ãŠå°ããã€æ·»å ãããåå¿ã
ã©ã¹ã³ã氷济ããååºãïŒæéæ¹æãããåŸãã
ãã«ãŠç¶ã®åºäœã宀枩ã§äžæ©æŸçœ®ãããåå¿æ··å
ç©ãçªçŽ ã§ããŒãžãããåŸãããåºäœã±ãŒãã埮
ç²æ«ã«ããã€ã¶ããæ°Žãããªç¡«é žãããªãŠã 液氎
ã§æŽæµããåŸä¹Ÿç¥ããç®ççæç©ãïŒâããã¢ç°
æ§äœãšå ±ã«åŸãïŒåé144.7ïœãèç¹112ã148
âïŒããã®çæç©ãæŽã«ç²Ÿè£œããããšãªã次ã®å·¥
çšã«çšããã
ïœ ããªãã»ãã³âïŒâã«ã«ãã³é ž å·¥çšïŒ¡ïŒïŒâããã¢âïœâãã«ã€ã«é ž 140ïœïŒ0.875ã¢ã«ïŒã®èçŽ åã³2.45ïœã®éç²ã
氷济äžã§å·åŽã93.31ïœïŒ0.7ã¢ã«ïŒïœâãã«ã€ã«
é žã15åéã«ããã€ãŠå°ããã€æ·»å ãããåå¿ã
ã©ã¹ã³ã氷济ããååºãïŒæéæ¹æãããåŸãã
ãã«ãŠç¶ã®åºäœã宀枩ã§äžæ©æŸçœ®ãããåå¿æ··å
ç©ãçªçŽ ã§ããŒãžãããåŸãããåºäœã±ãŒãã埮
ç²æ«ã«ããã€ã¶ããæ°Žãããªç¡«é žãããªãŠã 液氎
ã§æŽæµããåŸä¹Ÿç¥ããç®ççæç©ãïŒâããã¢ç°
æ§äœãšå ±ã«åŸãïŒåé144.7ïœãèç¹112ã148
âïŒããã®çæç©ãæŽã«ç²Ÿè£œããããšãªã次ã®å·¥
çšã«çšããã
å·¥çšïŒ¢ïŒïŒâããã¢âïœâãã«ã€ã«é
žã¡ãã«ãšã¹
ãã« 54.30ïœïŒ0.252ã¢ã«ïŒã®ïŒâããã¢âïœâãã«
ã€ã«é žã400mlã®ã¡ã¿ããŒã«åã³ïŒmlã®æ¿ç¡«é žã®
æ··åç©ã18.5æééæµããããã¡ã¿ããŒã«ãç空
é€å»ãããæ®æž£ããã³ãŒã³ã«æº¶è§£ããæ°Žãéçé ž
氎溶液ãæ°Žã§æŽæµåŸç¡æ°Žç¡«é žãã°ãã·ãŠã äžã§ä¹Ÿ
ç¥ãããã溶åªãç空é€å»ãããæ®æž£æ²¹ãèžçã
ãŠç®ççæç©ãïŒâããã¢ç°æ§äœãšå ±ã«ç¡è²ã®æ²¹
ãšããŠåŸãïŒåé41.6ïœã沞ç¹132ã135âïŒ0.1
mmïŒãæ²¹ãïŒæéå·èµåº«äžã§å·ããåºäœãåé¢ã
ãŠ12.53ïœã®çœè²åºäœãåŸãïŒèç¹42ã46âãäž»
ãšããŠïŒâããã¢ç°æ§äœïŒã
ãã« 54.30ïœïŒ0.252ã¢ã«ïŒã®ïŒâããã¢âïœâãã«
ã€ã«é žã400mlã®ã¡ã¿ããŒã«åã³ïŒmlã®æ¿ç¡«é žã®
æ··åç©ã18.5æééæµããããã¡ã¿ããŒã«ãç空
é€å»ãããæ®æž£ããã³ãŒã³ã«æº¶è§£ããæ°Žãéçé ž
氎溶液ãæ°Žã§æŽæµåŸç¡æ°Žç¡«é žãã°ãã·ãŠã äžã§ä¹Ÿ
ç¥ãããã溶åªãç空é€å»ãããæ®æž£æ²¹ãèžçã
ãŠç®ççæç©ãïŒâããã¢ç°æ§äœãšå ±ã«ç¡è²ã®æ²¹
ãšããŠåŸãïŒåé41.6ïœã沞ç¹132ã135âïŒ0.1
mmïŒãæ²¹ãïŒæéå·èµåº«äžã§å·ããåºäœãåé¢ã
ãŠ12.53ïœã®çœè²åºäœãåŸãïŒèç¹42ã46âãäž»
ãšããŠïŒâããã¢ç°æ§äœïŒã
å·¥çšïŒ£ïŒïŒâããã¢âαâããšããã·âïœâãã«
ã€ã«é žã¡ãã«ãšã¹ãã« ïŒâããã¢âïœâãã«ã€ã«é žã¡ãã«ãšã¹ãã«
17.48ïœïŒ0.0763ã¢ã«ïŒã®åå¡©åççŽ 85ml溶液ã
14.26ïœïŒ0.0801ã¢ã«ïŒã®ïŒ®âããã¢âãµã¯ã·ã
ããåã³152mgã®éé žåãã³ãŸã€ã«ã®æ··åç©ã§30
åéã«ããã€ãŠå°ããã€åŠçãããåŸãããæ··å
ç©ãïŒæéå ç±éæµãããã宀枩ãŸã§å·åŽåŸãµã¯
ã·ããããå¥ããã溶åªãç空é€å»ããŠÎ±ïŒïŒ
âãžããã¢âïœâãã«ã€ã«é žã¡ãã«ãšã¹ãã«ãé»
è²æ®æž£æ²¹ãšããŠåŸãã7.18ïœïŒ0.0763ã¢ã«ïŒã®ã
ãšããŒã«ã85mlã®ãžã¡ãã«ããªã«ã ã¢ããã
31.63ïœïŒ0.2289ã¢ã«ïŒã®çé žã«ãªãŠã åã³äžèš
ã§åŸãããαïŒïŒâãžããã¢âïœâãã«ã€ã«é žã¡
ãã«ãšã¹ãã«ã®æ··åç©ã55ã60âã§ïŒæéå ç±ã
ããæ··åç©ãå·åŽããŠ350mlã®æ°Žäžã«æ³šå ããã
åŸãããæ²¹ããšãŒãã«äžã«æœåºããæ°ŽæŽããŠç¡æ°Ž
ç¡«é žãã°ãã·ãŠã äžã§ä¹Ÿç¥ãããã溶åªãç空é€
å»ãæ®çæ²¹ïŒ24.51ïœïŒãäžæ©æŸçœ®ããã圢æã
ããæ··åç©ãå€åæ¿äžã«ãããŠåé¢ããããã®åº
äœãç³æ²¹ãšãŒãã«ã§æŽæµããç®çååç©ãåŸã
ãåé13.33ïœãèç¹69.5ã70.5âãpmrïŒCDCl3ïŒã
3.90ïŒ3HïŒïœïŒCH3OâïŒã5.40ïŒ2HïŒïœïŒCH2O
âïŒãã
ã€ã«é žã¡ãã«ãšã¹ãã« ïŒâããã¢âïœâãã«ã€ã«é žã¡ãã«ãšã¹ãã«
17.48ïœïŒ0.0763ã¢ã«ïŒã®åå¡©åççŽ 85ml溶液ã
14.26ïœïŒ0.0801ã¢ã«ïŒã®ïŒ®âããã¢âãµã¯ã·ã
ããåã³152mgã®éé žåãã³ãŸã€ã«ã®æ··åç©ã§30
åéã«ããã€ãŠå°ããã€åŠçãããåŸãããæ··å
ç©ãïŒæéå ç±éæµãããã宀枩ãŸã§å·åŽåŸãµã¯
ã·ããããå¥ããã溶åªãç空é€å»ããŠÎ±ïŒïŒ
âãžããã¢âïœâãã«ã€ã«é žã¡ãã«ãšã¹ãã«ãé»
è²æ®æž£æ²¹ãšããŠåŸãã7.18ïœïŒ0.0763ã¢ã«ïŒã®ã
ãšããŒã«ã85mlã®ãžã¡ãã«ããªã«ã ã¢ããã
31.63ïœïŒ0.2289ã¢ã«ïŒã®çé žã«ãªãŠã åã³äžèš
ã§åŸãããαïŒïŒâãžããã¢âïœâãã«ã€ã«é žã¡
ãã«ãšã¹ãã«ã®æ··åç©ã55ã60âã§ïŒæéå ç±ã
ããæ··åç©ãå·åŽããŠ350mlã®æ°Žäžã«æ³šå ããã
åŸãããæ²¹ããšãŒãã«äžã«æœåºããæ°ŽæŽããŠç¡æ°Ž
ç¡«é žãã°ãã·ãŠã äžã§ä¹Ÿç¥ãããã溶åªãç空é€
å»ãæ®çæ²¹ïŒ24.51ïœïŒãäžæ©æŸçœ®ããã圢æã
ããæ··åç©ãå€åæ¿äžã«ãããŠåé¢ããããã®åº
äœãç³æ²¹ãšãŒãã«ã§æŽæµããç®çååç©ãåŸã
ãåé13.33ïœãèç¹69.5ã70.5âãpmrïŒCDCl3ïŒã
3.90ïŒ3HïŒïœïŒCH3OâïŒã5.40ïŒ2HïŒïœïŒCH2O
âïŒãã
å·¥çšïŒ€ïŒïŒâããã¢âαâããšããã·âïœâãã«
ã€ã«é ž 13.33ïœïŒ0.0415ã¢ã«ïŒã®ïŒâããã¢âαâã
ãšããã·âïœâãã«ã€ã«é žã¡ãã«ãšã¹ãã«ãæ°Žé ž
åãããªãŠã 3.32ïœïŒ0.0830ã¢ã«ïŒæ°Ž23mlåã³ã¡
ã¿ããŒã«200mlã®æº¶æ¶²ã«æ·»å ãïŒæéå ç±éæµã
ãããã¡ã¿ããŒã«ãç空é€å»ãããæ®æž£ã200ml
ã®æ°Žã®æº¶è§£ãæ¿å¡©é žã§ã³ã³ãŽã¬ããã®çµç¹ãŸã§é ž
æ§åãããåºäœãå¥ä¹Ÿç¥ããŠç®ççæç©ãåŸã
ïŒåé12.02ïœãèç¹160ã163âïŒã
ã€ã«é ž 13.33ïœïŒ0.0415ã¢ã«ïŒã®ïŒâããã¢âαâã
ãšããã·âïœâãã«ã€ã«é žã¡ãã«ãšã¹ãã«ãæ°Žé ž
åãããªãŠã 3.32ïœïŒ0.0830ã¢ã«ïŒæ°Ž23mlåã³ã¡
ã¿ããŒã«200mlã®æº¶æ¶²ã«æ·»å ãïŒæéå ç±éæµã
ãããã¡ã¿ããŒã«ãç空é€å»ãããæ®æž£ã200ml
ã®æ°Žã®æº¶è§£ãæ¿å¡©é žã§ã³ã³ãŽã¬ããã®çµç¹ãŸã§é ž
æ§åãããåºäœãå¥ä¹Ÿç¥ããŠç®ççæç©ãåŸã
ïŒåé12.02ïœãèç¹160ã163âïŒã
å·¥çšïŒ¥ïŒïŒâããã¢âïŒïŒ11âãžãããâ11âãª
ããœãžãã³ãºãïœïŒïœ ããªãã»ãã³ 11.72ïœïŒ0.0381ã¢ã«ïŒã®ïŒâããã¢âαâã
ãšããã·âïœâãã«ã€ã«é žã70mlã®ç¡æ°Žããªããª
ãé ¢é žåã³ïŒmlã®é žããåããŠçŽ âãšãã«ãšãŒã
ã«é¯äœã®æ··åç©ã宀枩ã«ãããŠïŒæéæ¹æããã
åå¿æ··åç©ã750mlã®æ°·æ°Žã«æ³šå ãããåºäœã
å¥ä¹Ÿç¥ããŠç®ççæç©ãåŸãïŒåé10.70ïœãè
ç¹101ã104âïŒããããµã³ããåçµæ¶ããããè
ç¹107.5ã108.5âãpmrïŒCDClCïŒ5.10ïŒ2HïŒïœïŒ
CH2OâïŒãã
ããœãžãã³ãºãïœïŒïœ ããªãã»ãã³ 11.72ïœïŒ0.0381ã¢ã«ïŒã®ïŒâããã¢âαâã
ãšããã·âïœâãã«ã€ã«é žã70mlã®ç¡æ°Žããªããª
ãé ¢é žåã³ïŒmlã®é žããåããŠçŽ âãšãã«ãšãŒã
ã«é¯äœã®æ··åç©ã宀枩ã«ãããŠïŒæéæ¹æããã
åå¿æ··åç©ã750mlã®æ°·æ°Žã«æ³šå ãããåºäœã
å¥ä¹Ÿç¥ããŠç®ççæç©ãåŸãïŒåé10.70ïœãè
ç¹101ã104âïŒããããµã³ããåçµæ¶ããããè
ç¹107.5ã108.5âãpmrïŒCDClCïŒ5.10ïŒ2HïŒïœïŒ
CH2OâïŒãã
å
çŽ åæïŒC14H9BrC2ã«å¯Ÿããèšç®å€ïŒ
C58.16ïŒH3.14
枬å®å€ïŒC58.14ïŒH3.27
å·¥çšïŒŠïŒïŒïŒ11âãžãããâ11âãªããœãžãã³ãº
ãïœïŒïœ ããªãã»ãã³âïŒâã«ã«ããããªã« 9.13ïœïŒ0.0316ã¢ã«ïŒã®ïŒâããã¢âïŒïŒ11â
ãžãããâ11âãªããœãžãã³ãºãïœïŒïœ ããªãã»
ãã³ã6.03ïœïŒ0.0673ã¢ã«ïŒã®ã·ã¢ã³å第äžé å
ã³32mlã®ãžã¡ãã«ãã«ã ã¢ããã®æ··åç©ãæ¿ãã
æ¹æããªããéæµããããåå¿æ¶²ãå·åŽãã45ml
ã®ã¯ãããã«ã ã32mlã®é£œåã·ã¢ã³åãããªãŠã
溶液åã³32mlã®æ°Žã®æ··åç©ãšå ±ã«å šåºäœã溶解ã
ããŸã§æ¯ãšããããææ©å±€ãåé¢ãã·ã¢ã³åãã
ãªãŠã 溶液åã³æ°Žã§æŽæµãããç¡æ°Žç¡«é žãã°ãã·
ãŠã äžã§ä¹Ÿç¥ããã溶åªãé€å»ããŠç®ççæç©ã
åŸãïŒåé7.43ïœãèç¹116ã127âïŒã
ãïœïŒïœ ããªãã»ãã³âïŒâã«ã«ããããªã« 9.13ïœïŒ0.0316ã¢ã«ïŒã®ïŒâããã¢âïŒïŒ11â
ãžãããâ11âãªããœãžãã³ãºãïœïŒïœ ããªãã»
ãã³ã6.03ïœïŒ0.0673ã¢ã«ïŒã®ã·ã¢ã³å第äžé å
ã³32mlã®ãžã¡ãã«ãã«ã ã¢ããã®æ··åç©ãæ¿ãã
æ¹æããªããéæµããããåå¿æ¶²ãå·åŽãã45ml
ã®ã¯ãããã«ã ã32mlã®é£œåã·ã¢ã³åãããªãŠã
溶液åã³32mlã®æ°Žã®æ··åç©ãšå ±ã«å šåºäœã溶解ã
ããŸã§æ¯ãšããããææ©å±€ãåé¢ãã·ã¢ã³åãã
ãªãŠã 溶液åã³æ°Žã§æŽæµãããç¡æ°Žç¡«é žãã°ãã·
ãŠã äžã§ä¹Ÿç¥ããã溶åªãé€å»ããŠç®ççæç©ã
åŸãïŒåé7.43ïœãèç¹116ã127âïŒã
å·¥çšïŒ§ïŒïŒïŒ11âãžãããâ11âãªããœãžãã³ãº
ãïœïŒïœ ããªãã»ãã³âïŒâã«ã«ãã³é ž 7.43ïœïŒ0.0316ã¢ã«ïŒã®ïŒïŒ11âãžãããâ11
âãªããœãžãã³ãºãïœïŒïœ ããªãã»ãã³âïŒâã«
ã«ããããªã«ã130mlã®é ¢é žã13mlã®æ°Žåã³13ml
ã®æ¿å¡©é žã®æ··åç©ã156æééæµããããåå¿æ¶²
ãå·åŽãåºäœãå¥ä¹Ÿç¥ããïŒåé6.20ïœãèç¹
264ã269âïŒãé ¢é žããåçµæ¶ãããŠç®ççæç©
ãåŸãïŒèç¹270.5ã271.5âïŒã
ãïœïŒïœ ããªãã»ãã³âïŒâã«ã«ãã³é ž 7.43ïœïŒ0.0316ã¢ã«ïŒã®ïŒïŒ11âãžãããâ11
âãªããœãžãã³ãºãïœïŒïœ ããªãã»ãã³âïŒâã«
ã«ããããªã«ã130mlã®é ¢é žã13mlã®æ°Žåã³13ml
ã®æ¿å¡©é žã®æ··åç©ã156æééæµããããåå¿æ¶²
ãå·åŽãåºäœãå¥ä¹Ÿç¥ããïŒåé6.20ïœãèç¹
264ã269âïŒãé ¢é žããåçµæ¶ãããŠç®ççæç©
ãåŸãïŒèç¹270.5ã271.5âïŒã
å
çŽ åæïŒ
C5H10O4ã«å¯Ÿããèšç®å€ïŒC70.86ïŒH3.96
枬å®å€ïŒC71.08ïŒH4.24
å®æœäŸ ïŒ
ïŒïŒ11âãžãããâïŒâã€ãœãããã«â11âãª
ããœãžãã³ãºãïœïŒïœ ããªãã»ãã³âïŒâã«ã«
ãã³é ž å·¥çšïŒ¡ïŒã¡ãã«ïŒâããã¢âαâïŒïŒâã€ãœãã
ãã«ããšããã·ïŒâïœâãã«ãšãŒã å®æœäŸïŒå·¥çšïŒ¢ã«ãã€ãŠèª¿è£œãããã¡ãã«âïŒ
âããã¢âïœâãã«ãšãŒã15ïœïŒ0.0655ã¢ã«ïŒã®
åå¡©åççŽ 75ml溶液ãå°ããã€30åéã«ããã€ãŠ
12.24ïœïŒ0.0688ã¢ã«ïŒã®ïŒ®âããã¢ãµã¯ã·ãã
ã130mgã®éé žåãã³ãŸã€ã«ã®æ··åç©ã§åŠçããã
åŸãããæ··åç©ãïŒæéå ç±éæµãããã宀枩ã«
å·åŽåŸãµã¯ã·ããããå¥ããã溶åªãç空é€å»
ããŠÎ±ïŒïŒâãžããã¢âïœâãã«ã€ã«é žãšã¹ãã«
ãé»è²æ®çæ²¹ãšããŠåŸãã8.92ïœïŒ0.655ã¢ã«ïŒ
ã®ïŒâã€ãœãããã«ããšããŒã«ã75mlã®ãžã¡ãã«
ããªã«ã ã¢ããã27.16ïœïŒ0.1965ã¢ã«ïŒã®çé ž
ã«ãªãŠã åã³äžèšã§åŸãããαïŒïŒâãžããã¢â
ïœâãã«ã€ã«é žã¡ãã«ãšã¹ãã«ã®æ··åç©ã55ã60
âã§ïŒæéå ç±ãããæ··åç©ãå·åŽããŠ350mlã®
æ°Žäžã«æ³šå ãããåŸãããæ²¹ããšãŒãã«äžã«æœåº
ããæ°ŽæŽããç¡æ°Žç¡«é žãã°ãã·ãŠã äžã§ä¹Ÿç¥ãã
ãã溶åªãç空é€å»ããç®ççæç©ãæ©èµ€è²æ®ç
æ²¹ãšããŠåŸããåé23.7ïœãpmrïŒCDCl3ïŒ1.23
ïŒ6HïŒïœïŒïŒCH3ïŒ2CHâïŒã2.85ïŒ1HïŒïœïŒ
ïŒCH3ïŒ2CâïŒã3.90ïŒ3HïŒïœïŒCH2OâïŒã5.40
ïŒ2HïŒïœïŒCH2OâïŒãã
ããœãžãã³ãºãïœïŒïœ ããªãã»ãã³âïŒâã«ã«
ãã³é ž å·¥çšïŒ¡ïŒã¡ãã«ïŒâããã¢âαâïŒïŒâã€ãœãã
ãã«ããšããã·ïŒâïœâãã«ãšãŒã å®æœäŸïŒå·¥çšïŒ¢ã«ãã€ãŠèª¿è£œãããã¡ãã«âïŒ
âããã¢âïœâãã«ãšãŒã15ïœïŒ0.0655ã¢ã«ïŒã®
åå¡©åççŽ 75ml溶液ãå°ããã€30åéã«ããã€ãŠ
12.24ïœïŒ0.0688ã¢ã«ïŒã®ïŒ®âããã¢ãµã¯ã·ãã
ã130mgã®éé žåãã³ãŸã€ã«ã®æ··åç©ã§åŠçããã
åŸãããæ··åç©ãïŒæéå ç±éæµãããã宀枩ã«
å·åŽåŸãµã¯ã·ããããå¥ããã溶åªãç空é€å»
ããŠÎ±ïŒïŒâãžããã¢âïœâãã«ã€ã«é žãšã¹ãã«
ãé»è²æ®çæ²¹ãšããŠåŸãã8.92ïœïŒ0.655ã¢ã«ïŒ
ã®ïŒâã€ãœãããã«ããšããŒã«ã75mlã®ãžã¡ãã«
ããªã«ã ã¢ããã27.16ïœïŒ0.1965ã¢ã«ïŒã®çé ž
ã«ãªãŠã åã³äžèšã§åŸãããαïŒïŒâãžããã¢â
ïœâãã«ã€ã«é žã¡ãã«ãšã¹ãã«ã®æ··åç©ã55ã60
âã§ïŒæéå ç±ãããæ··åç©ãå·åŽããŠ350mlã®
æ°Žäžã«æ³šå ãããåŸãããæ²¹ããšãŒãã«äžã«æœåº
ããæ°ŽæŽããç¡æ°Žç¡«é žãã°ãã·ãŠã äžã§ä¹Ÿç¥ãã
ãã溶åªãç空é€å»ããç®ççæç©ãæ©èµ€è²æ®ç
æ²¹ãšããŠåŸããåé23.7ïœãpmrïŒCDCl3ïŒ1.23
ïŒ6HïŒïœïŒïŒCH3ïŒ2CHâïŒã2.85ïŒ1HïŒïœïŒ
ïŒCH3ïŒ2CâïŒã3.90ïŒ3HïŒïœïŒCH2OâïŒã5.40
ïŒ2HïŒïœïŒCH2OâïŒãã
å·¥çšïŒ¢ïŒïŒâããã¢âαâïŒïŒâã€ãœãããã«ã
ãšããã·ïŒâïœâãã«ã€ã«é ž 23.79ïœïŒ0.0655ã¢ã«ïŒã®ïŒâããã¢âαâïŒïŒ
âã€ãœãããã«ããšããã·ïŒâïœâãã«ã€ã«é žã¡
ãã«ãšã¹ãã«ãæ°Žé žåãããªãŠã 5.24ïœïŒ0.1310
ã¢ã«ïŒã®æ°Ž35mlåã³ã¡ã¿ããŒã«315mlã®æº¶æ¶²ã«æ·»
å ãããïŒæéå ç±éæµåŸãã¡ã¿ããŒã«ãç空é€
å»ãæ®ç溶液ã300mlã®æ°Žã§çšéããããšãŒãã«
ã§æœåºããæ°Žå±€ãæ¿å¡©é žã§ã³ã³ãŽã¬ããçµç¹ãŸã§
é žæ§åãããåŸãããæ²¹ããšãŒãã«äžã«æœåºãã
æ°ŽæŽããç¡«é žãã°ãã·ãŠã äžã§ä¹Ÿç¥ãããã溶åª
ãç空é€å»ããŠæ®çæ²¹ïŒ21.33ïœïŒãäžæ©æŸçœ®ã
ãã圢æãããåºäœãç³æ²¹ãšãŒãã«ã§æŽæµããç®
çååç©ãåŸãããåé10.94ïœãèç¹103ã122
âãpmrïŒCDCl3ïŒ1.20ïŒ6HïŒïœïŒïŒCH3ïŒ2CHâïŒã
2.82ïŒ1HïŒïœïŒïŒCH3ïŒ2CHâïŒã5.47ïŒ2HïŒïœïŒ
CH2OâïŒã9.18ïŒ1HïŒãããŒãïœïŒCOOïŒã å·¥çšïŒ£ïŒïŒâããã¢âïŒïŒ11âãžãããâïŒâã€
ãœãããã«â11âãªããœãžãã³ãºãïœïŒïœ ããª
ãã»ãã³ 9.54ïœïŒ0.0273ã¢ã«ïŒã®ïŒâããã¢âαâïŒïŒ
âã€ãœãããã«ããšããã·ïŒâïœâãã«ã€ã«é žã
80mlã®ç¡æ°Žããªãã«ãªãé ¢é žåã³5.7mlã®ããå
ããŠçŽ ãšãã«ãšãŒãã«ã宀枩ã«ãããŠïŒæéæ¹æ
ãããåå¿æ¶²ã600mlã®æ°·æ°Žäžã«æ³šããåŸããã
æ²¹ããšãŒãã«äžã«æœåºãæ°ŽæŽåŸç¡æ°Žç¡«é žãã°ãã·
ãŠã äžã§ä¹Ÿç¥ãããã溶åªãç空é€å»ãããåŸã
ããæ²¹ïŒ8.96ïœïŒããã³ãŒã³å¯Ÿã·ã¯ããããµã³ã®
ïŒïŒïŒæ··åç©ã溶é¢æ¶²ãšããŠçšããŠã·ãªã«ã²ã«ã®
ã«ã©ã ã¯ãããã°ã©ãã€ãŒã«ãã€ãŠç²Ÿè£œããŠç®ç
çæç©ãé»è²æ®çæ²¹ãšããŠåŸããåé6.39ïœãã
ã³ãŒã³âã·ã¯ãããã¿ã³ïŒïŒïŒïŒïŒã溶åªç³»ãšã
ãã·ãªã«ã²ã«äžã®èå±€ã¯ãããã°ã©ãã«ãããŠå
äžã¹ããããRfïŒ0.33ã瀺ããpmrïŒCDCl3ïŒ1.20
ïŒ6HïŒïœïŒïŒCH3ïŒ2âCHâïŒã2.82ïŒ1HïŒïœïŒ
ïŒCH3ïŒ2CïŒã5.08ïŒ2HïŒïŒïŒCH2OâïŒã å·¥çšïŒ€ïŒïŒïŒ11âãžãããâïŒâã€ãœãããã«â
11âãªããœãžãã³ãºãïœïŒïœ ããªãã»ãã³âïŒ
âã«ã«ããããªã« 8.39ïœïŒ0.0253ã¢ã«ïŒã®ïŒâããã¢âïŒâ11â
ãžãããâïŒâã€ãœãããã«â11âãªããœãžãã³
ãºãïœïŒïœ ããªãã»ãã³ã4.83ïœïŒ0.0539ã¢ã«ïŒ
ã®ã·ã¢ã³å第äžé åã³30mlã®ãžã¡ãã«ãã«ã ã¢ã
ãã®æ··åç©ãæ¿ããæ¹æããªããïŒæééæµãã
ããåå¿æ¶²ãå·åŽãã36mlã®ã¯ãããã«ã ã25ml
ã®é£œåã·ã¢ã³åãããªãŠã 溶液åã³25mlã®æ°Žãšå ±
ã«å šåºäœã溶解ãããŸã§æ¯ãšãããããææ©å±€ã
åé¢ããã·ã¢ã³åãããªãŠã 氎溶液åã³æ°Žã§æŽæµ
ããç¡æ°Žç¡«é žãããªãŠã äžã§ä¹Ÿç¥ãããã溶åªã
ç空é€å»ããåŸãããæ²¹ããã³ãŒã³ã溶é¢æ¶²ãšã
ãŠçšããŠã·ãªã«ã²ã«ã«ã©ã ã¯ãããã°ã©ãã«ãã
åŸãããæ²¹ïŒ7.01ïœïŒã粟補ããŠç®ççæç©ãåŸ
ãããåé2.8ïœãèç¹101ã108âããã³ãŒã³ã溶
åªç³»ãšããã·ãªã«ã²ã«ã®èå±€ã¯ãããã°ã©ãã«ã
ããŠåäžã¹ããããRfïŒ0.18ã瀺ããpmr
ïŒCDCl3ïŒ1.23ïŒ6HïŒïœïŒïŒCH3ïŒ2ïŒCHâïŒã2.95
ïŒ1HïŒïœïŒïŒCH3ïŒ2CâïŒã5.20ïŒ2HïŒïœïŒ
CH2OïŒã å·¥çšïŒ¥ïŒïŒïŒ11âãžãããâïŒâã€ãœãããã«â
11âãªããœãžãã³ãºãïœïŒïœ ããªãã»ãã³âïŒ
âã«ã«ãã³é ž 2.8ïœïŒ0.010ã¢ã«ïŒã®ïŒïŒ11âãžãããâïŒâ
ã€ãœãããã«â11âãªããœãžãã³ãºãïœïŒïœ ããª
ãã»ãã³âïŒâã«ã«ããããªã«ã50mlã®é ¢é žãïŒ
mlã®æ°Žåã³ïŒmlã®æ¿å¡©é žã®æ··åç©ã140æééæµ
ããããåå¿æ¶²ãå·åŽãåºäœãå¥ããŠä¹Ÿç¥ãã
ãïŒåé2.07ïœãèç¹202ã204âïŒããã«ãšã³ã
ãåçµæ¶ãããŠç®ççæç©ãåŸããïŒèç¹203ã
204.5âïŒã
ãšããã·ïŒâïœâãã«ã€ã«é ž 23.79ïœïŒ0.0655ã¢ã«ïŒã®ïŒâããã¢âαâïŒïŒ
âã€ãœãããã«ããšããã·ïŒâïœâãã«ã€ã«é žã¡
ãã«ãšã¹ãã«ãæ°Žé žåãããªãŠã 5.24ïœïŒ0.1310
ã¢ã«ïŒã®æ°Ž35mlåã³ã¡ã¿ããŒã«315mlã®æº¶æ¶²ã«æ·»
å ãããïŒæéå ç±éæµåŸãã¡ã¿ããŒã«ãç空é€
å»ãæ®ç溶液ã300mlã®æ°Žã§çšéããããšãŒãã«
ã§æœåºããæ°Žå±€ãæ¿å¡©é žã§ã³ã³ãŽã¬ããçµç¹ãŸã§
é žæ§åãããåŸãããæ²¹ããšãŒãã«äžã«æœåºãã
æ°ŽæŽããç¡«é žãã°ãã·ãŠã äžã§ä¹Ÿç¥ãããã溶åª
ãç空é€å»ããŠæ®çæ²¹ïŒ21.33ïœïŒãäžæ©æŸçœ®ã
ãã圢æãããåºäœãç³æ²¹ãšãŒãã«ã§æŽæµããç®
çååç©ãåŸãããåé10.94ïœãèç¹103ã122
âãpmrïŒCDCl3ïŒ1.20ïŒ6HïŒïœïŒïŒCH3ïŒ2CHâïŒã
2.82ïŒ1HïŒïœïŒïŒCH3ïŒ2CHâïŒã5.47ïŒ2HïŒïœïŒ
CH2OâïŒã9.18ïŒ1HïŒãããŒãïœïŒCOOïŒã å·¥çšïŒ£ïŒïŒâããã¢âïŒïŒ11âãžãããâïŒâã€
ãœãããã«â11âãªããœãžãã³ãºãïœïŒïœ ããª
ãã»ãã³ 9.54ïœïŒ0.0273ã¢ã«ïŒã®ïŒâããã¢âαâïŒïŒ
âã€ãœãããã«ããšããã·ïŒâïœâãã«ã€ã«é žã
80mlã®ç¡æ°Žããªãã«ãªãé ¢é žåã³5.7mlã®ããå
ããŠçŽ ãšãã«ãšãŒãã«ã宀枩ã«ãããŠïŒæéæ¹æ
ãããåå¿æ¶²ã600mlã®æ°·æ°Žäžã«æ³šããåŸããã
æ²¹ããšãŒãã«äžã«æœåºãæ°ŽæŽåŸç¡æ°Žç¡«é žãã°ãã·
ãŠã äžã§ä¹Ÿç¥ãããã溶åªãç空é€å»ãããåŸã
ããæ²¹ïŒ8.96ïœïŒããã³ãŒã³å¯Ÿã·ã¯ããããµã³ã®
ïŒïŒïŒæ··åç©ã溶é¢æ¶²ãšããŠçšããŠã·ãªã«ã²ã«ã®
ã«ã©ã ã¯ãããã°ã©ãã€ãŒã«ãã€ãŠç²Ÿè£œããŠç®ç
çæç©ãé»è²æ®çæ²¹ãšããŠåŸããåé6.39ïœãã
ã³ãŒã³âã·ã¯ãããã¿ã³ïŒïŒïŒïŒïŒã溶åªç³»ãšã
ãã·ãªã«ã²ã«äžã®èå±€ã¯ãããã°ã©ãã«ãããŠå
äžã¹ããããRfïŒ0.33ã瀺ããpmrïŒCDCl3ïŒ1.20
ïŒ6HïŒïœïŒïŒCH3ïŒ2âCHâïŒã2.82ïŒ1HïŒïœïŒ
ïŒCH3ïŒ2CïŒã5.08ïŒ2HïŒïŒïŒCH2OâïŒã å·¥çšïŒ€ïŒïŒïŒ11âãžãããâïŒâã€ãœãããã«â
11âãªããœãžãã³ãºãïœïŒïœ ããªãã»ãã³âïŒ
âã«ã«ããããªã« 8.39ïœïŒ0.0253ã¢ã«ïŒã®ïŒâããã¢âïŒâ11â
ãžãããâïŒâã€ãœãããã«â11âãªããœãžãã³
ãºãïœïŒïœ ããªãã»ãã³ã4.83ïœïŒ0.0539ã¢ã«ïŒ
ã®ã·ã¢ã³å第äžé åã³30mlã®ãžã¡ãã«ãã«ã ã¢ã
ãã®æ··åç©ãæ¿ããæ¹æããªããïŒæééæµãã
ããåå¿æ¶²ãå·åŽãã36mlã®ã¯ãããã«ã ã25ml
ã®é£œåã·ã¢ã³åãããªãŠã 溶液åã³25mlã®æ°Žãšå ±
ã«å šåºäœã溶解ãããŸã§æ¯ãšãããããææ©å±€ã
åé¢ããã·ã¢ã³åãããªãŠã 氎溶液åã³æ°Žã§æŽæµ
ããç¡æ°Žç¡«é žãããªãŠã äžã§ä¹Ÿç¥ãããã溶åªã
ç空é€å»ããåŸãããæ²¹ããã³ãŒã³ã溶é¢æ¶²ãšã
ãŠçšããŠã·ãªã«ã²ã«ã«ã©ã ã¯ãããã°ã©ãã«ãã
åŸãããæ²¹ïŒ7.01ïœïŒã粟補ããŠç®ççæç©ãåŸ
ãããåé2.8ïœãèç¹101ã108âããã³ãŒã³ã溶
åªç³»ãšããã·ãªã«ã²ã«ã®èå±€ã¯ãããã°ã©ãã«ã
ããŠåäžã¹ããããRfïŒ0.18ã瀺ããpmr
ïŒCDCl3ïŒ1.23ïŒ6HïŒïœïŒïŒCH3ïŒ2ïŒCHâïŒã2.95
ïŒ1HïŒïœïŒïŒCH3ïŒ2CâïŒã5.20ïŒ2HïŒïœïŒ
CH2OïŒã å·¥çšïŒ¥ïŒïŒïŒ11âãžãããâïŒâã€ãœãããã«â
11âãªããœãžãã³ãºãïœïŒïœ ããªãã»ãã³âïŒ
âã«ã«ãã³é ž 2.8ïœïŒ0.010ã¢ã«ïŒã®ïŒïŒ11âãžãããâïŒâ
ã€ãœãããã«â11âãªããœãžãã³ãºãïœïŒïœ ããª
ãã»ãã³âïŒâã«ã«ããããªã«ã50mlã®é ¢é žãïŒ
mlã®æ°Žåã³ïŒmlã®æ¿å¡©é žã®æ··åç©ã140æééæµ
ããããåå¿æ¶²ãå·åŽãåºäœãå¥ããŠä¹Ÿç¥ãã
ãïŒåé2.07ïœãèç¹202ã204âïŒããã«ãšã³ã
ãåçµæ¶ãããŠç®ççæç©ãåŸããïŒèç¹203ã
204.5âïŒã
å
çŽ åæïŒC18H16O4ã«å¯Ÿãã
èšç®å€ïŒC72.96ïŒH5.44
枬å®å€ïŒC73.16ïŒH5.62
å®æœäŸ ïŒ
ïŒïŒ11âãžãããâïŒïŒïŒâã¡ãã¬ã³ãžãªãã·
â11âãªããœãžãã³ãºãïœïŒïœ ããªãã»ãã³â
ïŒâã«ã«ãã³é ž å·¥çšïŒ¡ïŒïŒâããã¢âαâïŒïŒïŒïŒâã¡ãã¬ã³ãž
ãªãã·ããšããã·ïŒâïœâãã«ã€ã«é žã¡ãã«ãš
ã¹ãã« ïŒâããã¢âïœâãã«ã€ã«é žã¡ãã«ãšã¹ãã«
15.0ïœïŒ0.0655ã¢ã«ïŒã®åå¡©åççŽ 75ml溶液ãå°
ããã€30åéã«ããã€ãŠ12.83ïœïŒ0.0721ã¢ã«ïŒ
ã®ïŒ®âããã¢âãµã¯ã·ãããåã³130mgã®éé žå
ãã³ãŸã€ã«ã®æ··åç©ã§åŠçãããåŸãããæ··åç©
ãïŒæééæµå ç±ããã宀枩ã«å·åŽåŸãµã¯ã·ãã
ããå¥ããã溶åªãç空é€å»ãã¡ãã«Î±ïŒïŒâ
ãžããã¢âïœâãã«ãšãŒããé»è²æ®çæ²¹ãšããŠåŸ
ãã9.05ïœïŒ0.0655ã¢ã«ïŒã®ïŒïŒïŒâã¡ãã¬ã³ãž
ãªãã·ããšããŒã«ã75mlã®ãžã¡ãã«ãã«ã ã¢ã
ãã27.16ïœïŒ0.1965ã¢ã«ïŒã®çé žã«ãªãŠã åã³
äžèšã§åŸãããαïŒïŒâãžããã¢âïœâãã«ã€ã«
é žã¡ãã«ãšã¹ãã«ã55ã60âã§ïŒæéå ç±ããã
æ··åç©ãå·åŽã350mlã®æ°Žã«æ³šå ãããåŸããã
æ²¹ããšãŒãã«äžã«æœåºããæ°ŽæŽåŸç¡æ°Žç¡«é žãã°ã
ã·ãŠã äžã§ä¹Ÿç¥ããã溶åªãç空é€å»ããŠç®çç
æç©ãã¯ãã¯ã¹ç¶åºäœãšããŠåŸãïŒåé23.92
ïœïŒãã·ã¯ããããµã³ããåçµæ¶ããŠé»è²éç¶çµ
æ¶ãšããŠçŽç²çæç©ãåŸãããåé16.12ïœãèç¹
93ã98âãpmrïŒCDCl3ïŒ3.88ïŒ3HïŒïœïŒCH3O
âïŒã5.30ïŒ2HïŒïœïŒCH2OâïŒã5.85ïŒ2HïŒïœïŒ
OCH2OâïŒã å·¥çšïŒ¢ïŒïŒâããã¢âαâïŒïŒïŒïŒâã¡ãã¬ã³ãž
ãªãã·ããšããã·ïŒâïœâãã«ã€ã«é ž 16.07ïœïŒ0.044ã¢ã«ïŒã®ïŒâããã¢âαâïŒïŒïŒ
ïŒâã¡ãã¬ã³ãžãªãã·ããšããã·ïŒâïœâãã«ã€
ã«é žã¡ãã«ãšã¹ãã«ãæ°Žé žåãããªãŠã 3.52ïœ
ïŒ0.088ã¢ã«ïŒã®æ°Ž24mlåã³ã¡ã¿ããŒã«212mlã®æº¶
液ã«æ·»å ãããæ··åç©ãïŒæéå ç±éæµãããã
ã¡ã¿ããŒã«ãç空é€å»ãæ®æž£ã225mlã®æ°Žã«æº¶è§£
ãããæ¿å¡©é žã§ã³ã³ãŽã¬ããçµç¹ãŸã§é žæ§åãã
ããåºäœãå¥ããŠä¹Ÿç¥ããããïŒåé14.14ïœã
èç¹167ã177âïŒããšã¿ããŒã«âæ°Žããåçµæ¶ã
ããŠé»è€è²éç¶çµæ¶ãšããŠçŽç²çæç©ãåŸãã
ïŒèç¹177ã180âïŒ å·¥çšïŒ£ïŒïŒâããã¢âïŒïŒ11âãžãããâïŒïŒïŒ
âã¡ãã¬ã³ãžãªãã·â11âãªããœâãžãã³ãº
ãïœïŒïœ ããªãã»ãã³ 11.0ïœïŒ0.0313ã¢ã«ïŒã®ïŒâããã¢âαâïŒïŒïŒ
ïŒâã¡ãã¬ã³ãžãªãã·ããšããã·ïŒâïœâãã«ã€
ã«é žã90mlã®ç¡æ°Žããªãã«ãªãé ¢é žåã³ïŒmlã®ã
ãåããŠçŽ ãšãã«ãšãŒãã«ã®æ··åç©ã宀枩ã§23æ
éæ¹æãããåå¿æ¶²ã660mlã®æ°·æ°Žã«æ³šããåºäœ
ãå¥ããŠä¹Ÿç¥ããïŒåé10.43ïœãèç¹148ã
172âïŒãã€ãœãããã«ã¢ã«ã³ãŒã«ããåçµæ¶ãã
ãŠé»è€è²éç¶çµæ¶ãšããŠçŽç²çæç©ãåŸãããè
ç¹178ã180âãpmrïŒCDCl3ïŒ5.05ïŒ2HïŒïœïŒ
CH2OâïŒã5.97ïŒ2HïŒïœïŒOCH2OâïŒã å·¥çšïŒ€ïŒïŒïŒ11âãžãããâïŒïŒïŒâã¡ãã¬ã³ãž
ãªãã·â11âãªããœãžãã³ãºãïœïŒïœ ããªãã»
ãã³âïŒâã«ã«ããããªã« 9.26ïœïŒ0.0278ã¢ã«ïŒã®ïŒâããã¢âïŒïŒ11â
ãžãããâïŒïŒïŒâã¡ãã¬ã³ãžãªãã·â11âãªã
ãœãžãã³ãºãïœïŒïœ ããªãã»ãã³ã5.23ïœ
ïŒ0.0584ã¢ã«ïŒã®ã·ã¢ã³å第äžé åã³33mlã®ãžã¡
ãã«ãã«ã ã¢ããã®æ··åç©ãæ¿ããæ¹æããªãã
ïŒæéå ç±éæµããããåå¿æ¶²ãå·åŽãã45mlã®
ã¯ãããã«ã ã32mlã®é£œåã·ã¢ã³åãããªãŠã 溶
液åã³32mlã®æ°Žã®æ··åç©ãšå ±ã«å šåºäœã溶解ãã
ããŸã§æ¯ãšãããããææ©å±€ãåé¢ããã·ã¢ã³å
ãããªãŠã 氎溶液åã³æ°Žã§æŽæµããç¡æ°Žç¡«é žãã°
ãã·ãŠã äžã§ä¹Ÿç¥ãããã溶åªãç空é€å»ããŠç®
ççæç©ãåŸãïŒåé7.76ïœãèç¹217ã220âïŒã
é ¢é žããåçµæ¶ãããŠé»è€è²ã®ããªãºã ç¶çµæ¶ãš
ããŠçŽç²çæç©ãåŸãããèç¹224ã225âãpmr
ïŒCDCl3ïŒ5.03ïŒ2HïŒïœïŒCH2OïŒã617ïŒ2HïŒïœïŒ
OCH2OâïŒã å·¥çšïŒ¥ïŒïŒïŒ11âãžãããâïŒïŒïŒâã¡ãã¬ã³ãž
ãªãã·â11âãªããœâãžãã³ãºãïœïŒïœ ããªã
ã»ãã³âïŒâã«ã«ãã³é ž 4.98ïœïŒ0.0178ã¢ã«ïŒã®ïŒïŒ11âãžãããâ
ïŒïŒïŒâã¡ãã¬ã³ãžãªãã·â11âãªããœãžãã³ãº
ãïœïŒïœ ããªãã»ãã³âïŒâã«ã«ããããªã«ã90
mlã®é ¢é žãïŒmlã®æ¿å¡©é žã®æ··åç©ã74æéå ç±é
æµããããåå¿æ¶²ãå·åŽãåºäœãå¥ããŠä¹Ÿç¥ã
ãïŒåé3.45ïœïŒããã®åºäœãæ°Žã«æžæ¿ããâ
ã¡ãã«ããã©ãžã³ã§åŠçãããå¡©åºäžæº¶ç©ãå¥
é€å»ã液ãæ¿å¡©é žã§ã³ã³ãŽã¬ããçµç¹ãŸã§é žæ§
åãããåºäœãå¥ããŠä¹Ÿç¥ããããé ¢é žããå
çµæ¶ã«ãã粟補ããŠçæç©ãåŸããïŒèç¹320ã
321âïŒã
â11âãªããœãžãã³ãºãïœïŒïœ ããªãã»ãã³â
ïŒâã«ã«ãã³é ž å·¥çšïŒ¡ïŒïŒâããã¢âαâïŒïŒïŒïŒâã¡ãã¬ã³ãž
ãªãã·ããšããã·ïŒâïœâãã«ã€ã«é žã¡ãã«ãš
ã¹ãã« ïŒâããã¢âïœâãã«ã€ã«é žã¡ãã«ãšã¹ãã«
15.0ïœïŒ0.0655ã¢ã«ïŒã®åå¡©åççŽ 75ml溶液ãå°
ããã€30åéã«ããã€ãŠ12.83ïœïŒ0.0721ã¢ã«ïŒ
ã®ïŒ®âããã¢âãµã¯ã·ãããåã³130mgã®éé žå
ãã³ãŸã€ã«ã®æ··åç©ã§åŠçãããåŸãããæ··åç©
ãïŒæééæµå ç±ããã宀枩ã«å·åŽåŸãµã¯ã·ãã
ããå¥ããã溶åªãç空é€å»ãã¡ãã«Î±ïŒïŒâ
ãžããã¢âïœâãã«ãšãŒããé»è²æ®çæ²¹ãšããŠåŸ
ãã9.05ïœïŒ0.0655ã¢ã«ïŒã®ïŒïŒïŒâã¡ãã¬ã³ãž
ãªãã·ããšããŒã«ã75mlã®ãžã¡ãã«ãã«ã ã¢ã
ãã27.16ïœïŒ0.1965ã¢ã«ïŒã®çé žã«ãªãŠã åã³
äžèšã§åŸãããαïŒïŒâãžããã¢âïœâãã«ã€ã«
é žã¡ãã«ãšã¹ãã«ã55ã60âã§ïŒæéå ç±ããã
æ··åç©ãå·åŽã350mlã®æ°Žã«æ³šå ãããåŸããã
æ²¹ããšãŒãã«äžã«æœåºããæ°ŽæŽåŸç¡æ°Žç¡«é žãã°ã
ã·ãŠã äžã§ä¹Ÿç¥ããã溶åªãç空é€å»ããŠç®çç
æç©ãã¯ãã¯ã¹ç¶åºäœãšããŠåŸãïŒåé23.92
ïœïŒãã·ã¯ããããµã³ããåçµæ¶ããŠé»è²éç¶çµ
æ¶ãšããŠçŽç²çæç©ãåŸãããåé16.12ïœãèç¹
93ã98âãpmrïŒCDCl3ïŒ3.88ïŒ3HïŒïœïŒCH3O
âïŒã5.30ïŒ2HïŒïœïŒCH2OâïŒã5.85ïŒ2HïŒïœïŒ
OCH2OâïŒã å·¥çšïŒ¢ïŒïŒâããã¢âαâïŒïŒïŒïŒâã¡ãã¬ã³ãž
ãªãã·ããšããã·ïŒâïœâãã«ã€ã«é ž 16.07ïœïŒ0.044ã¢ã«ïŒã®ïŒâããã¢âαâïŒïŒïŒ
ïŒâã¡ãã¬ã³ãžãªãã·ããšããã·ïŒâïœâãã«ã€
ã«é žã¡ãã«ãšã¹ãã«ãæ°Žé žåãããªãŠã 3.52ïœ
ïŒ0.088ã¢ã«ïŒã®æ°Ž24mlåã³ã¡ã¿ããŒã«212mlã®æº¶
液ã«æ·»å ãããæ··åç©ãïŒæéå ç±éæµãããã
ã¡ã¿ããŒã«ãç空é€å»ãæ®æž£ã225mlã®æ°Žã«æº¶è§£
ãããæ¿å¡©é žã§ã³ã³ãŽã¬ããçµç¹ãŸã§é žæ§åãã
ããåºäœãå¥ããŠä¹Ÿç¥ããããïŒåé14.14ïœã
èç¹167ã177âïŒããšã¿ããŒã«âæ°Žããåçµæ¶ã
ããŠé»è€è²éç¶çµæ¶ãšããŠçŽç²çæç©ãåŸãã
ïŒèç¹177ã180âïŒ å·¥çšïŒ£ïŒïŒâããã¢âïŒïŒ11âãžãããâïŒïŒïŒ
âã¡ãã¬ã³ãžãªãã·â11âãªããœâãžãã³ãº
ãïœïŒïœ ããªãã»ãã³ 11.0ïœïŒ0.0313ã¢ã«ïŒã®ïŒâããã¢âαâïŒïŒïŒ
ïŒâã¡ãã¬ã³ãžãªãã·ããšããã·ïŒâïœâãã«ã€
ã«é žã90mlã®ç¡æ°Žããªãã«ãªãé ¢é žåã³ïŒmlã®ã
ãåããŠçŽ ãšãã«ãšãŒãã«ã®æ··åç©ã宀枩ã§23æ
éæ¹æãããåå¿æ¶²ã660mlã®æ°·æ°Žã«æ³šããåºäœ
ãå¥ããŠä¹Ÿç¥ããïŒåé10.43ïœãèç¹148ã
172âïŒãã€ãœãããã«ã¢ã«ã³ãŒã«ããåçµæ¶ãã
ãŠé»è€è²éç¶çµæ¶ãšããŠçŽç²çæç©ãåŸãããè
ç¹178ã180âãpmrïŒCDCl3ïŒ5.05ïŒ2HïŒïœïŒ
CH2OâïŒã5.97ïŒ2HïŒïœïŒOCH2OâïŒã å·¥çšïŒ€ïŒïŒïŒ11âãžãããâïŒïŒïŒâã¡ãã¬ã³ãž
ãªãã·â11âãªããœãžãã³ãºãïœïŒïœ ããªãã»
ãã³âïŒâã«ã«ããããªã« 9.26ïœïŒ0.0278ã¢ã«ïŒã®ïŒâããã¢âïŒïŒ11â
ãžãããâïŒïŒïŒâã¡ãã¬ã³ãžãªãã·â11âãªã
ãœãžãã³ãºãïœïŒïœ ããªãã»ãã³ã5.23ïœ
ïŒ0.0584ã¢ã«ïŒã®ã·ã¢ã³å第äžé åã³33mlã®ãžã¡
ãã«ãã«ã ã¢ããã®æ··åç©ãæ¿ããæ¹æããªãã
ïŒæéå ç±éæµããããåå¿æ¶²ãå·åŽãã45mlã®
ã¯ãããã«ã ã32mlã®é£œåã·ã¢ã³åãããªãŠã 溶
液åã³32mlã®æ°Žã®æ··åç©ãšå ±ã«å šåºäœã溶解ãã
ããŸã§æ¯ãšãããããææ©å±€ãåé¢ããã·ã¢ã³å
ãããªãŠã 氎溶液åã³æ°Žã§æŽæµããç¡æ°Žç¡«é žãã°
ãã·ãŠã äžã§ä¹Ÿç¥ãããã溶åªãç空é€å»ããŠç®
ççæç©ãåŸãïŒåé7.76ïœãèç¹217ã220âïŒã
é ¢é žããåçµæ¶ãããŠé»è€è²ã®ããªãºã ç¶çµæ¶ãš
ããŠçŽç²çæç©ãåŸãããèç¹224ã225âãpmr
ïŒCDCl3ïŒ5.03ïŒ2HïŒïœïŒCH2OïŒã617ïŒ2HïŒïœïŒ
OCH2OâïŒã å·¥çšïŒ¥ïŒïŒïŒ11âãžãããâïŒïŒïŒâã¡ãã¬ã³ãž
ãªãã·â11âãªããœâãžãã³ãºãïœïŒïœ ããªã
ã»ãã³âïŒâã«ã«ãã³é ž 4.98ïœïŒ0.0178ã¢ã«ïŒã®ïŒïŒ11âãžãããâ
ïŒïŒïŒâã¡ãã¬ã³ãžãªãã·â11âãªããœãžãã³ãº
ãïœïŒïœ ããªãã»ãã³âïŒâã«ã«ããããªã«ã90
mlã®é ¢é žãïŒmlã®æ¿å¡©é žã®æ··åç©ã74æéå ç±é
æµããããåå¿æ¶²ãå·åŽãåºäœãå¥ããŠä¹Ÿç¥ã
ãïŒåé3.45ïœïŒããã®åºäœãæ°Žã«æžæ¿ããâ
ã¡ãã«ããã©ãžã³ã§åŠçãããå¡©åºäžæº¶ç©ãå¥
é€å»ã液ãæ¿å¡©é žã§ã³ã³ãŽã¬ããçµç¹ãŸã§é žæ§
åãããåºäœãå¥ããŠä¹Ÿç¥ããããé ¢é žããå
çµæ¶ã«ãã粟補ããŠçæç©ãåŸããïŒèç¹320ã
321âïŒã
å
çŽ åæïŒC16H10O6ã«å¯Ÿãã
èšç®å€ïŒC64.43ïŒH3.38
枬å®å€ïŒC64.58ïŒH3.53
å®æœäŸ ïŒ
ïŒâïŒ1Hâããã©ãŸãŒã«âïŒâã€ã«ïŒâïŒïŒ11
âãžãããâ11âãªããœãžãã³ãºãïœïŒïœ ããª
ãã»ãã³ 25ïœïŒ0.106ã¢ã«ïŒã®ïŒâã·ã¢ãâïŒïŒ11âãž
ãããâ11âãªããœãžãã³ãºãïœïŒïœ ããªãã»ã
ã³ã8.28ïœïŒ0.127ã¢ã«ïŒã®ãããªãŠã ã¢ãžãå
ã³7.37ïœïŒ0.138ã¢ã«ïŒã®å¡©åã¢ã³ã¢ããŠã ã®æ··
åç©ã250mlã®ïŒ®ïŒïŒ®âãžã¡ãã«ãã«ã ã¢ããäž
ã§140âã«27æéå ç±ãããå·åŽãã500c.c.ã®æ°Žã§
çšéããŠ20ïŒ å¡©é žæ°Žæº¶æ¶²ã§é žæ§åãããåºäœã
å¥åé¢ããšã¿ããŒã«ããçµæ¶åãããŠç®ççæç©
ãåŸãïŒèç¹248âãå解ïŒã
âãžãããâ11âãªããœãžãã³ãºãïœïŒïœ ããª
ãã»ãã³ 25ïœïŒ0.106ã¢ã«ïŒã®ïŒâã·ã¢ãâïŒïŒ11âãž
ãããâ11âãªããœãžãã³ãºãïœïŒïœ ããªãã»ã
ã³ã8.28ïœïŒ0.127ã¢ã«ïŒã®ãããªãŠã ã¢ãžãå
ã³7.37ïœïŒ0.138ã¢ã«ïŒã®å¡©åã¢ã³ã¢ããŠã ã®æ··
åç©ã250mlã®ïŒ®ïŒïŒ®âãžã¡ãã«ãã«ã ã¢ããäž
ã§140âã«27æéå ç±ãããå·åŽãã500c.c.ã®æ°Žã§
çšéããŠ20ïŒ å¡©é žæ°Žæº¶æ¶²ã§é žæ§åãããåºäœã
å¥åé¢ããšã¿ããŒã«ããçµæ¶åãããŠç®ççæç©
ãåŸãïŒèç¹248âãå解ïŒã
å®æœäŸ ïŒ
ïŒâïŒ1Hâããã©ãŸãŒã«âïŒâã€ã«ïŒâïŒïŒ11
âãžãããâ11âãªããœãžãã³ãºãïœïŒïœ ããª
ãã»ãã³ å®æœäŸïŒãå·¥çšïŒŠã®ãããªã«800mgããããªãŠ
ã ã¢ãžã293ïœåã³å¡©åã¢ã³ã¢ããŠã 265mgã25ml
ã®ãžã¡ãã«ãã«ã ã¢ããäžã§130ã135âã§ïŒæé
å ç±ãããæ··åç©ãæ°Žåã³éå°ã®çé žãããªãŠã
ã§çšéãããé ¢é žãšãã«ã§æœåºããæ°Žå±€ãé žæ§å
ããæåºç©ãå¥åé¢ããŠç®ççæç©ãåŸãã
âãžãããâ11âãªããœãžãã³ãºãïœïŒïœ ããª
ãã»ãã³ å®æœäŸïŒãå·¥çšïŒŠã®ãããªã«800mgããããªãŠ
ã ã¢ãžã293ïœåã³å¡©åã¢ã³ã¢ããŠã 265mgã25ml
ã®ãžã¡ãã«ãã«ã ã¢ããäžã§130ã135âã§ïŒæé
å ç±ãããæ··åç©ãæ°Žåã³éå°ã®çé žãããªãŠã
ã§çšéãããé ¢é žãšãã«ã§æœåºããæ°Žå±€ãé žæ§å
ããæåºç©ãå¥åé¢ããŠç®ççæç©ãåŸãã
å®æœäŸ ïŒ
ïŒâïŒïŒâããããã·âïŒïŒïŒïŒïŒâãã¢ãžã¢
ãŸãŒã«âïŒâã€ã«ïŒâïŒïŒ11âãžãããâ11â
ãªããœãžãã³ãºãïœïŒïœ ããªãã»ãã³ å·¥çšïŒ¡ïŒïŒïŒ11âãžãããâ11âãªããœãžãã³ãº
ãïœïŒïœ ããªãã»ãã³âïŒâã«ã«ãã¯ã¹ã¢ã«ã
ãã 5.0ïœã®ïŒâã·ã¢ãâïŒïŒ11âãžãããâ11â
ãªããœãžãã³ãºãïœïŒïœ ããªãã»ãã³åã³75ïŒ
ïŒïŒ¶ïŒïŒ¶ïŒã®é žæ°Žæº¶æ¶²60mläžã«å«ãŸããã©ããŒã
ãã±ã«åé4.0ïœãéæµç¹ã«ãããŠ1.5æéå ç±ã
ãã宀枩ã«ãŸã§å·åŽãéãããå°å®¹éãŸã§æ¿çž®
ããå¡©åã¡ãã¬ã³ã§æœåºãè¡ããæœåºç©ãæ°Žåã³
éçé žãããªãŠã ã§äžæ§ã«ãªããŸã§æŽæµãããäž
æ§æœåºç©ãç¡«é žãããªãŠã äžã§ä¹Ÿç¥ãããæ¿çž®ä¹Ÿ
åºããç®ççæç©ãåŸãã
ãŸãŒã«âïŒâã€ã«ïŒâïŒïŒ11âãžãããâ11â
ãªããœãžãã³ãºãïœïŒïœ ããªãã»ãã³ å·¥çšïŒ¡ïŒïŒïŒ11âãžãããâ11âãªããœãžãã³ãº
ãïœïŒïœ ããªãã»ãã³âïŒâã«ã«ãã¯ã¹ã¢ã«ã
ãã 5.0ïœã®ïŒâã·ã¢ãâïŒïŒ11âãžãããâ11â
ãªããœãžãã³ãºãïœïŒïœ ããªãã»ãã³åã³75ïŒ
ïŒïŒ¶ïŒïŒ¶ïŒã®é žæ°Žæº¶æ¶²60mläžã«å«ãŸããã©ããŒã
ãã±ã«åé4.0ïœãéæµç¹ã«ãããŠ1.5æéå ç±ã
ãã宀枩ã«ãŸã§å·åŽãéãããå°å®¹éãŸã§æ¿çž®
ããå¡©åã¡ãã¬ã³ã§æœåºãè¡ããæœåºç©ãæ°Žåã³
éçé žãããªãŠã ã§äžæ§ã«ãªããŸã§æŽæµãããäž
æ§æœåºç©ãç¡«é žãããªãŠã äžã§ä¹Ÿç¥ãããæ¿çž®ä¹Ÿ
åºããç®ççæç©ãåŸãã
å·¥çšïŒ¢ïŒïŒâã¢ããâïŒâïŒïŒïŒ11âãžãããâ
11âãªããœãžãã³ãºãïœïŒïœ ããªãã»ãã³âïŒ
âã€ã«ïŒã¢ã»ããããªã« 5.85ïœã®å¡©åã¢ã³ã¢ããŠã ã5.35ïœã®ã·ã¢ã³å
ãããªãŠã ã75mlã®æ°Žé žåã¢ã³ã¢ããŠã ã100ml
ã®ã¢ã³ã¢ãã¢ã§é£œåããããšã¿ããŒã«åã³12ïœã®
å·¥çšïŒ¡ã®ã«ã«ãã¯ã¹ã¢ã«ãããã®æ··åç©ã宀枩ã§
12æéæ¹æãããåå¿æ¶²ã300mlã®æ°Žäžã«æ³šå ãã
ãšãŒãã«ã§æœåºãããæœåºç©ãç¡«é žãããªãŠã äž
ã§ä¹Ÿç¥ãããæ¿çž®ä¹ŸåºããŠç®ççæç©ãåŸãã
11âãªããœãžãã³ãºãïœïŒïœ ããªãã»ãã³âïŒ
âã€ã«ïŒã¢ã»ããããªã« 5.85ïœã®å¡©åã¢ã³ã¢ããŠã ã5.35ïœã®ã·ã¢ã³å
ãããªãŠã ã75mlã®æ°Žé žåã¢ã³ã¢ããŠã ã100ml
ã®ã¢ã³ã¢ãã¢ã§é£œåããããšã¿ããŒã«åã³12ïœã®
å·¥çšïŒ¡ã®ã«ã«ãã¯ã¹ã¢ã«ãããã®æ··åç©ã宀枩ã§
12æéæ¹æãããåå¿æ¶²ã300mlã®æ°Žäžã«æ³šå ãã
ãšãŒãã«ã§æœåºãããæœåºç©ãç¡«é žãããªãŠã äž
ã§ä¹Ÿç¥ãããæ¿çž®ä¹ŸåºããŠç®ççæç©ãåŸãã
å·¥çšïŒ£ïŒïŒâã¢ããâïŒâïŒïŒïŒ11âãžãããâ
11âãªããœãžãã³ãºãïœïŒïœ ããªãã»ãã³âïŒ
âã€ã«ïŒã¢ã»ã¿ãã å·¥çšïŒ¢ã®ã¢ããã¢ã»ããããªã«5.0ïœãæ¿å¡©é ž
30mläžã§å®€æž©ã«ãããŠ30åéæ¹æãããåå¿æ¶²ã
å·æ°Žé žåã¢ã³ã¢ããŠã äžã«ãã€ãã泚ããæ··åç©
ããšãŒãã«ã§æœåºããŠãç¡«é žãããªãŠã äžã§ä¹Ÿç¥
ããããæœåºç©ãèžçºä¹ŸåºãããŠç®ççæç©ãåŸ
ãã
11âãªããœãžãã³ãºãïœïŒïœ ããªãã»ãã³âïŒ
âã€ã«ïŒã¢ã»ã¿ãã å·¥çšïŒ¢ã®ã¢ããã¢ã»ããããªã«5.0ïœãæ¿å¡©é ž
30mläžã§å®€æž©ã«ãããŠ30åéæ¹æãããåå¿æ¶²ã
å·æ°Žé žåã¢ã³ã¢ããŠã äžã«ãã€ãã泚ããæ··åç©
ããšãŒãã«ã§æœåºããŠãç¡«é žãããªãŠã äžã§ä¹Ÿç¥
ããããæœåºç©ãèžçºä¹ŸåºãããŠç®ççæç©ãåŸ
ãã
å·¥çšïŒ€ïŒïŒâïŒïŒâããããã·âïŒïŒïŒïŒïŒâã
ã¢ãžã¢ãŸãŒã«âïŒâã€ã«ïŒâïŒïŒ11âãžããã
â11âãžãã³ãºãïœïŒïœ ããªãã»ãã³ å·¥çšïŒ£ã®ã¢ã»ã¿ãã1.365ïœãäžå¡©åã€ãªãŠ
1.989ïœåã³ãžã¡ãã«ãã«ã ã¢ããïŒmlã®æ··åç©
ã宀枩ã§äžæ©æ¹æãããåå¿æ¶²ãéãã次ãã§
æ°·æ°ŽïŒ75mlïŒåã³é ¢é žãšãã«ïŒ75mlïŒã®éã§åé
ãè¡ããææ©å±€ãéåé¢ãã飜åå¡©åãããªãŠ
ã 氎溶液ã§æŽæµããç¡«é žãã°ãã·ãŠã äžã§ä¹Ÿç¥ã
ããèžçºä¹ŸåºããŠæ®æž£ã200mlã®æ²žéš°ãšã¿ããŒã«
äžã«æº¶è§£ããæšçã§åŠçããéããã25mlã«æ¿
çž®ããåºäœãå¥ããŠç®ççæç©ãåŸããïŒèç¹
275ã278âïŒã
ã¢ãžã¢ãŸãŒã«âïŒâã€ã«ïŒâïŒïŒ11âãžããã
â11âãžãã³ãºãïœïŒïœ ããªãã»ãã³ å·¥çšïŒ£ã®ã¢ã»ã¿ãã1.365ïœãäžå¡©åã€ãªãŠ
1.989ïœåã³ãžã¡ãã«ãã«ã ã¢ããïŒmlã®æ··åç©
ã宀枩ã§äžæ©æ¹æãããåå¿æ¶²ãéãã次ãã§
æ°·æ°ŽïŒ75mlïŒåã³é ¢é žãšãã«ïŒ75mlïŒã®éã§åé
ãè¡ããææ©å±€ãéåé¢ãã飜åå¡©åãããªãŠ
ã 氎溶液ã§æŽæµããç¡«é žãã°ãã·ãŠã äžã§ä¹Ÿç¥ã
ããèžçºä¹ŸåºããŠæ®æž£ã200mlã®æ²žéš°ãšã¿ããŒã«
äžã«æº¶è§£ããæšçã§åŠçããéããã25mlã«æ¿
çž®ããåºäœãå¥ããŠç®ççæç©ãåŸããïŒèç¹
275ã278âïŒã
äžèšå·¥çšïŒ¡ã§çšããããïŒâã·ã¢ãâïŒïŒ11â
ãžãããâ11âãªããœãžãã³ãºãïœïŒïœ ããªãã»
ãã³ã®ä»£ãã«ïŒâã·ã¢ãâïŒïŒ11âãžãããâ11
âãªããœãžãã³ãºãïœïŒïœ ããªãã»ãã³ãçšãã
ããšã«ãã察å¿ããïŒâïŒïŒâããããã·âïŒïŒ
ïŒïŒïŒâãã¢ãžã¢ãŸãŒã«âïŒâã€ã«ïŒâïŒïŒ11â
ãžããããã·â11âãªããœãžãã³ãºãïœïŒïœ ããª
ãã»ãã³ãåŸãããã
ãžãããâ11âãªããœãžãã³ãºãïœïŒïœ ããªãã»
ãã³ã®ä»£ãã«ïŒâã·ã¢ãâïŒïŒ11âãžãããâ11
âãªããœãžãã³ãºãïœïŒïœ ããªãã»ãã³ãçšãã
ããšã«ãã察å¿ããïŒâïŒïŒâããããã·âïŒïŒ
ïŒïŒïŒâãã¢ãžã¢ãŸãŒã«âïŒâã€ã«ïŒâïŒïŒ11â
ãžããããã·â11âãªããœãžãã³ãºãïœïŒïœ ããª
ãã»ãã³ãåŸãããã
å®æœäŸ ïŒ
ïŒâïŒïŒâããããã·âÎ3âãããªã³âïŒïŒïŒ
âãžãªã³âïŒâã€ã«ïŒâïŒïŒ11âãžãããâ11
âãªããœãžãã³ãºãïœïŒïœ ããªãã»ãã³ å·¥çšïŒ¡ïŒïŒâïŒïŒâã«ã«ããã·ãã³ãžã«ãªãã·ïŒ
ããšãã«é ¢é ž 15mlã®40ïŒ æ°Žé žåãããªãŠã 氎溶液ãš11.41ïœ
ã®ïœâããããã·ããšãã«é ¢é žãšãæ··åããããš
ã«ããïœâããããã·ããšãã«é ¢é žã®äºãããªãŠ
ã å¡©ã調補ãããæ··åç©ãèžçºä¹Ÿåºãããã³ãŒã³
ã§åŠçããŠæ®çæ°Žãé€å»ãããèžçºä¹ŸåºããŠåŸã
ããåºäœæ®æž£ã10ïœã®ãã¿ã©ã€ããšå ±ã«180âã«
ãããŠ30åéã次ãã§210âã«ãããŠ2.5æéæ¹æ
ãããå·åŽããŠã300mlã®æ°Žã«æº¶è§£ãããå¡©é žã§
é žæ§ã«ããæåºç©ãå¥ããŠç®ççæç©ãã¯ãªãŒ
ã ç¶çè²åºäœãšããŠåŸãïŒèç¹171ã174âã
lit.181ã183âçµæ¶åïŒã
âãžãªã³âïŒâã€ã«ïŒâïŒïŒ11âãžãããâ11
âãªããœãžãã³ãºãïœïŒïœ ããªãã»ãã³ å·¥çšïŒ¡ïŒïŒâïŒïŒâã«ã«ããã·ãã³ãžã«ãªãã·ïŒ
ããšãã«é ¢é ž 15mlã®40ïŒ æ°Žé žåãããªãŠã 氎溶液ãš11.41ïœ
ã®ïœâããããã·ããšãã«é ¢é žãšãæ··åããããš
ã«ããïœâããããã·ããšãã«é ¢é žã®äºãããªãŠ
ã å¡©ã調補ãããæ··åç©ãèžçºä¹Ÿåºãããã³ãŒã³
ã§åŠçããŠæ®çæ°Žãé€å»ãããèžçºä¹ŸåºããŠåŸã
ããåºäœæ®æž£ã10ïœã®ãã¿ã©ã€ããšå ±ã«180âã«
ãããŠ30åéã次ãã§210âã«ãããŠ2.5æéæ¹æ
ãããå·åŽããŠã300mlã®æ°Žã«æº¶è§£ãããå¡©é žã§
é žæ§ã«ããæåºç©ãå¥ããŠç®ççæç©ãã¯ãªãŒ
ã ç¶çè²åºäœãšããŠåŸãïŒèç¹171ã174âã
lit.181ã183âçµæ¶åïŒã
å·¥çšïŒ¢ïŒïŒïŒ11âãžãããâ11âãªããœãžãã³ãº
ãïœïŒïœ ããªãã»ãã³âïŒâé ¢é ž å·¥çšïŒ¡ã®ã«ã«ããã·ãã³ãžã«ãªãã·ããšãã«é ¢
é ž12ïœãå å§ãã³å ã®50mlã®ç¡æ°Žããªãã«ãªãé ¢
é žäžã«æžæ¿ãã70ã80âã§2.25æéæ¹æãããå
å¿æ¶²ãèžçºãããŠã·ãããç¶ã«ãããããã50ml
ã®ããã©ããããã©ã³ã«æº¶è§£ãPHïŒã«ãªããŸã§ç
é žãããªãŠã ã§åŠçããã15åéæ¹æããŠ
5NHClã§é žæ§ã«ãããæ°Žã§çšéããŠãšãŒãã«ã§
æœåºãè¡ããæœåºç©ãæ°Žã§æŽæµããç¡«é žãã°ãã·
ãŠã äžã§ä¹Ÿç¥ããããæ¿çž®ä¹ŸåºããŠãé ¢é žãšã
ã«ïŒãããµã³ããåçµæ¶ãããŠç®ççæç©ãåŸ
ãã
ãïœïŒïœ ããªãã»ãã³âïŒâé ¢é ž å·¥çšïŒ¡ã®ã«ã«ããã·ãã³ãžã«ãªãã·ããšãã«é ¢
é ž12ïœãå å§ãã³å ã®50mlã®ç¡æ°Žããªãã«ãªãé ¢
é žäžã«æžæ¿ãã70ã80âã§2.25æéæ¹æãããå
å¿æ¶²ãèžçºãããŠã·ãããç¶ã«ãããããã50ml
ã®ããã©ããããã©ã³ã«æº¶è§£ãPHïŒã«ãªããŸã§ç
é žãããªãŠã ã§åŠçããã15åéæ¹æããŠ
5NHClã§é žæ§ã«ãããæ°Žã§çšéããŠãšãŒãã«ã§
æœåºãè¡ããæœåºç©ãæ°Žã§æŽæµããç¡«é žãã°ãã·
ãŠã äžã§ä¹Ÿç¥ããããæ¿çž®ä¹ŸåºããŠãé ¢é žãšã
ã«ïŒãããµã³ããåçµæ¶ãããŠç®ççæç©ãåŸ
ãã
å·¥çšïŒ£ïŒïŒïŒ11âãžãããâ11âãªããœãžãã³ãº
ãïœïŒïœ ããªãã»ãã³âïŒâã¢ã»ã¿ãã å·¥çšïŒ¢ããåŸãããé ž5.0ïœåã³å¡©åããªãã«
40mlã®æ··åç©ã20åééæµãããã30mlãã€ã®å
å¡©åççŽ ãçšããŠïŒåèžçºãè¡ããæ®æž£ã20mlã®
ããã©ããããã©ã³ã«æº¶è§£ããåŸããã溶液ãå·
åŽãããŠãæ¹æããã60mlã®ããã©ããããã©ã³
ã¢ã³ã¢ãã¢é£œå溶液ïŒæ°·æµŽïŒã«æ»ŽäžããããããŠ
åæ§ã«æº¶æ¶²äžã«ã¢ã³ã¢ãã¢ãééããããæ¹æã
宀枩ã«ãããŠæŽã«15åéç¶ãããæ··åç©ãèžçºä¹Ÿ
åºãããã12mlã®ãšã¿ããŒã«åã³60mlã®æ°Žã®æ··å
ç©ãæ·»å ããŠæžæ¿æ¶²ã30åéæ¹æãããåºäœãå
é¢ããæ°ŽæŽãã次ãã§ãšã¿ããŒã«ã§æŽæµããæåŸ
ã«ãšãŒãã«ã§æŽæµããŠç®ççæç©ãåŸãã
ãïœïŒïœ ããªãã»ãã³âïŒâã¢ã»ã¿ãã å·¥çšïŒ¢ããåŸãããé ž5.0ïœåã³å¡©åããªãã«
40mlã®æ··åç©ã20åééæµãããã30mlãã€ã®å
å¡©åççŽ ãçšããŠïŒåèžçºãè¡ããæ®æž£ã20mlã®
ããã©ããããã©ã³ã«æº¶è§£ããåŸããã溶液ãå·
åŽãããŠãæ¹æããã60mlã®ããã©ããããã©ã³
ã¢ã³ã¢ãã¢é£œå溶液ïŒæ°·æµŽïŒã«æ»ŽäžããããããŠ
åæ§ã«æº¶æ¶²äžã«ã¢ã³ã¢ãã¢ãééããããæ¹æã
宀枩ã«ãããŠæŽã«15åéç¶ãããæ··åç©ãèžçºä¹Ÿ
åºãããã12mlã®ãšã¿ããŒã«åã³60mlã®æ°Žã®æ··å
ç©ãæ·»å ããŠæžæ¿æ¶²ã30åéæ¹æãããåºäœãå
é¢ããæ°ŽæŽãã次ãã§ãšã¿ããŒã«ã§æŽæµããæåŸ
ã«ãšãŒãã«ã§æŽæµããŠç®ççæç©ãåŸãã
å·¥çšïŒ€ïŒïŒâïŒïŒâããããã·âÎ3âãããªã³â
ïŒïŒïŒâãžãªã³âïŒâã€ã«ïŒâïŒïŒ11âãžãã
ãâ11âãªããœãžãã³ãºãïœïŒïœ ããªãã»ãã³ å·¥çšïŒ£ã®ã¢ãã5.118ïœãã·ãŠãŠé žãžãšãã«
2.939ïœãã«ãªãŠã ïœâãããã·ã4.723ïœåã³ãž
ã¡ãã«ãã«ã ã¢ãã40mlã®æ··åç©ã宀枩ã§ïŒæé
æ¹æãããåå¿æ¶²ã300mlã®æ°·âæ°Žã«æ³šãã300ml
ã®é ¢é žãšãã«ã§æœåºããã6Nå¡©é žã§é žæ§ã«ãã
é ¢é žãšãã«ã§æœåºãè¡ãã飜åå¡©åãããªãŠã æ°Ž
溶液ã§æŽæµããç¡«é žãã°ãã·ãŠã äžã§ä¹Ÿç¥ãã
ããèžçºä¹ŸåºãããŠæ®æž£ãæž©ããæ°Žâãžãªããµã³
äžã«æº¶è§£ãããããéå°ã®æ¿æ°Žé žåã¢ã³ã¢ããŠã
ã§åŠçããåºäœãå¥ããããžãªããµã³ã§æŽæµ
åŸã也ç¥ããããåºäœãæ°ŽïŒ400mlïŒã«æžæ¿ãã
ãã6Nå¡©é žã§é žæ§ã«ããŠé ¢é žãšãã«ã§æœåºãè¡
ããæœåºç©ã飜åå¡©åãããªãŠã 氎溶液ã§æœåº
ããç¡«é žãã°ãã·ãŠã äžã§ä¹Ÿç¥ãããçŽ15mlãŸã§
èžçºãè¡ããæ®æž£ã沞隰ãããŸã§å ç±ããïŒæé
宀枩ã«æŸçœ®ãããåºäœãå¥ããé ¢é žãšãã«ã§æŽ
æµããŠç®ççæç©ãåŸãïŒèç¹278ã280âãå
解ïŒã
ïŒïŒïŒâãžãªã³âïŒâã€ã«ïŒâïŒïŒ11âãžãã
ãâ11âãªããœãžãã³ãºãïœïŒïœ ããªãã»ãã³ å·¥çšïŒ£ã®ã¢ãã5.118ïœãã·ãŠãŠé žãžãšãã«
2.939ïœãã«ãªãŠã ïœâãããã·ã4.723ïœåã³ãž
ã¡ãã«ãã«ã ã¢ãã40mlã®æ··åç©ã宀枩ã§ïŒæé
æ¹æãããåå¿æ¶²ã300mlã®æ°·âæ°Žã«æ³šãã300ml
ã®é ¢é žãšãã«ã§æœåºããã6Nå¡©é žã§é žæ§ã«ãã
é ¢é žãšãã«ã§æœåºãè¡ãã飜åå¡©åãããªãŠã æ°Ž
溶液ã§æŽæµããç¡«é žãã°ãã·ãŠã äžã§ä¹Ÿç¥ãã
ããèžçºä¹ŸåºãããŠæ®æž£ãæž©ããæ°Žâãžãªããµã³
äžã«æº¶è§£ãããããéå°ã®æ¿æ°Žé žåã¢ã³ã¢ããŠã
ã§åŠçããåºäœãå¥ããããžãªããµã³ã§æŽæµ
åŸã也ç¥ããããåºäœãæ°ŽïŒ400mlïŒã«æžæ¿ãã
ãã6Nå¡©é žã§é žæ§ã«ããŠé ¢é žãšãã«ã§æœåºãè¡
ããæœåºç©ã飜åå¡©åãããªãŠã 氎溶液ã§æœåº
ããç¡«é žãã°ãã·ãŠã äžã§ä¹Ÿç¥ãããçŽ15mlãŸã§
èžçºãè¡ããæ®æž£ã沞隰ãããŸã§å ç±ããïŒæé
宀枩ã«æŸçœ®ãããåºäœãå¥ããé ¢é žãšãã«ã§æŽ
æµããŠç®ççæç©ãåŸãïŒèç¹278ã280âãå
解ïŒã
å®æœäŸ ïŒ
ïŒâïŒïŒâããããã·âÎ3âãããªã³âïŒïŒïŒ
âãžãªã³âïŒâã€ã«ïŒâïŒïŒ11âãžãããâ11
âãªããœãžãã³ãºãïœïŒïœ ããªãã»ãã³ å·¥çšïŒ¡ïŒïŒâããšããã·ã¡ãã«âïŒâã¡ãã«å®æ¯
éŠé ž 1.0ïœã®ïŒâã¡ãã«ãã¿ã©ã€ãåã³0.64ïœã®ã
ããªãŠã ããšãã¬ãŒãã200ã210âã®æž©åºŠã§ïŒæ
éæ¹æãããåå¿æ¶²ãå·åŽãæ°Žã«æº¶è§£ãããïŒïŒ
ã®å¡©é žã§é žæ§ã«ããŠããšãŒãã«ã§æœåºãè¡ããèž
çºä¹Ÿåºããæ®æž£ãã·ãªã«ã²ã«äžã§ã¯ãããã«ã ïŒ
ã¡ã¿ããŒã«ïŒ50ïŒïŒïŒã§æº¶é¢ãããŠã¯ãããã°ã©
ããè¡ãã溶é¢æ¶²ãèžçºä¹Ÿåºããæ®æž£ãé ¢é žãšã
ã«ïŒãã³ãŒã³ããçµæ¶åãããŠç®ççæç©ãåŸ
ãã
âãžãªã³âïŒâã€ã«ïŒâïŒïŒ11âãžãããâ11
âãªããœãžãã³ãºãïœïŒïœ ããªãã»ãã³ å·¥çšïŒ¡ïŒïŒâããšããã·ã¡ãã«âïŒâã¡ãã«å®æ¯
éŠé ž 1.0ïœã®ïŒâã¡ãã«ãã¿ã©ã€ãåã³0.64ïœã®ã
ããªãŠã ããšãã¬ãŒãã200ã210âã®æž©åºŠã§ïŒæ
éæ¹æãããåå¿æ¶²ãå·åŽãæ°Žã«æº¶è§£ãããïŒïŒ
ã®å¡©é žã§é žæ§ã«ããŠããšãŒãã«ã§æœåºãè¡ããèž
çºä¹Ÿåºããæ®æž£ãã·ãªã«ã²ã«äžã§ã¯ãããã«ã ïŒ
ã¡ã¿ããŒã«ïŒ50ïŒïŒïŒã§æº¶é¢ãããŠã¯ãããã°ã©
ããè¡ãã溶é¢æ¶²ãèžçºä¹Ÿåºããæ®æž£ãé ¢é žãšã
ã«ïŒãã³ãŒã³ããçµæ¶åãããŠç®ççæç©ãåŸ
ãã
å·¥çšïŒ¢ïŒïŒâã¡ãã«âïŒïŒ11âãžãããâ11âãª
ããœãžãã³ãºãïœïŒïœ ããªãã»ãã³ å·¥çšïŒ¡ã®ããšããã·ã¡ãã«å®æ¯éŠé ž0.2ïœå¡©å
ããªãã«ïŒmlã也ç¥ãã³ãŒã³10mlãæ··åãããïŒ
æééæµããåŸãç空äžã§æ¿çž®ä¹Ÿåºããããæ®æž£
ã10mlã®ä¹Ÿç¥ïŒïŒïŒâãžã¯ãããšã¿ã³ã«æº¶è§£ãã
氷济äžã§æ¹æãããªããç¡æ°Žå¡©åã¢ã«ãããŠã
0.3ïœãæ·»å ããã10ååŸã«åå¿æ¶²ãæ°·æ°Žã«æ³šãã
ã¯ãããã«ã ã§æœåºãæ°ŽæŽããŠç¡«é žãã°ãã·ãŠã
äžã§ä¹Ÿç¥ããããæ¿çž®ä¹Ÿåºããæ®æž£ãã¯ãããã«
ã ã§æº¶é¢ããªããã·ãªã«ã²ã«äžã§ã¯ãããã°ã©ã
ãè¡ãã溶é¢æ¶²ãæ¿çž®ä¹ŸåºããŠãããµã³ããçµæ¶
åãããŠç®ççæç©ãåŸãã
ããœãžãã³ãºãïœïŒïœ ããªãã»ãã³ å·¥çšïŒ¡ã®ããšããã·ã¡ãã«å®æ¯éŠé ž0.2ïœå¡©å
ããªãã«ïŒmlã也ç¥ãã³ãŒã³10mlãæ··åãããïŒ
æééæµããåŸãç空äžã§æ¿çž®ä¹Ÿåºããããæ®æž£
ã10mlã®ä¹Ÿç¥ïŒïŒïŒâãžã¯ãããšã¿ã³ã«æº¶è§£ãã
氷济äžã§æ¹æãããªããç¡æ°Žå¡©åã¢ã«ãããŠã
0.3ïœãæ·»å ããã10ååŸã«åå¿æ¶²ãæ°·æ°Žã«æ³šãã
ã¯ãããã«ã ã§æœåºãæ°ŽæŽããŠç¡«é žãã°ãã·ãŠã
äžã§ä¹Ÿç¥ããããæ¿çž®ä¹Ÿåºããæ®æž£ãã¯ãããã«
ã ã§æº¶é¢ããªããã·ãªã«ã²ã«äžã§ã¯ãããã°ã©ã
ãè¡ãã溶é¢æ¶²ãæ¿çž®ä¹ŸåºããŠãããµã³ããçµæ¶
åãããŠç®ççæç©ãåŸãã
å·¥çšïŒ£ïŒïŒâããã¢ã¡ãã«âïŒïŒ11âãžãããâ
11âãªããœãžãã³ãºãïœïŒïœ ããªãã»ãã³ å·¥çšïŒ¢ã®ïŒâã¡ãã«ååç©2.0ïœã®ïŒïŒïŒâãž
ããã¢ãšã¿ã³ïŒmlã®æ¹æãããŠç §å°ãããïŒã¿ã³
ã°ã¹ãã³ã©ã³ãïŒæº¶æ¶²ã«èçŽ 1.7ïœã®ïŒïŒïŒâãž
ããã¢ãšã¿ã³ïŒml溶液ãïŒæéã«äºã€ãŠ150âã§
滎äžãããåå¿æ··åç©ãå·åŽããæ°·æ°Žã«æ³šããæ°Ž
ã§æœåºããç¡«é žãããªãŠã äžã§ä¹Ÿç¥ããããæ¿çž®
也åºããæ®æž£ãã€ãœãããã«ãšãŒãã«ããçµæ¶å
ãããŠç®ççæç©ãåŸãã
11âãªããœãžãã³ãºãïœïŒïœ ããªãã»ãã³ å·¥çšïŒ¢ã®ïŒâã¡ãã«ååç©2.0ïœã®ïŒïŒïŒâãž
ããã¢ãšã¿ã³ïŒmlã®æ¹æãããŠç §å°ãããïŒã¿ã³
ã°ã¹ãã³ã©ã³ãïŒæº¶æ¶²ã«èçŽ 1.7ïœã®ïŒïŒïŒâãž
ããã¢ãšã¿ã³ïŒml溶液ãïŒæéã«äºã€ãŠ150âã§
滎äžãããåå¿æ··åç©ãå·åŽããæ°·æ°Žã«æ³šããæ°Ž
ã§æœåºããç¡«é žãããªãŠã äžã§ä¹Ÿç¥ããããæ¿çž®
也åºããæ®æž£ãã€ãœãããã«ãšãŒãã«ããçµæ¶å
ãããŠç®ççæç©ãåŸãã
å·¥çšïŒ€ïŒïŒâã·ã¢ãã¡ãã«âïŒïŒ11âãžãããâ
11âãªããœãžãã³ãºãïœïŒïœ ããªãã»ãã³ å·¥çšïŒ£ã®ããã¢ã¡ãã«ååç©6.4ïœããžã¡ãã«
ãã«ã ã¢ãã75c.c.ã«æº¶è§£ãã2.95ïœã®ã·ã¢ã³åã
ããªãŠã ãæ·»å ãããæ··åç©ã宀枩ã«ãããŠ1.5
æéæ¹æããã600c.c.ã®æ°Žã§çšéãè¡ããïŒåãš
ãŒãã«ã§æœåºãè¡ããææ©æœåºç©ãåäœããŠæ°Žã§
æŽæµãã也ç¥ãã溶åªãé€å»ããŠåºäœæ®æž£ãåŸ
ãããããµã³äžã§ç²ç ãè¡ããåºäœãéã«ãã
ååããã
11âãªããœãžãã³ãºãïœïŒïœ ããªãã»ãã³ å·¥çšïŒ£ã®ããã¢ã¡ãã«ååç©6.4ïœããžã¡ãã«
ãã«ã ã¢ãã75c.c.ã«æº¶è§£ãã2.95ïœã®ã·ã¢ã³åã
ããªãŠã ãæ·»å ãããæ··åç©ã宀枩ã«ãããŠ1.5
æéæ¹æããã600c.c.ã®æ°Žã§çšéãè¡ããïŒåãš
ãŒãã«ã§æœåºãè¡ããææ©æœåºç©ãåäœããŠæ°Žã§
æŽæµãã也ç¥ãã溶åªãé€å»ããŠåºäœæ®æž£ãåŸ
ãããããµã³äžã§ç²ç ãè¡ããåºäœãéã«ãã
ååããã
å·¥çšïŒ¥ïŒïŒïŒ11âãžãããâ11âãªããœãžãã³ãº
ãïœïŒïœ ããªãã»ãã³âïŒâé ¢é ž å·¥çšïŒ€ã®ãããªã«2.0ïœã30c.c.ã®20ïŒ æ°Žé žåã
ããªãŠã 溶液åã³30c.c.ã®ãšã¿ããŒã«æ··åç©äžã§ïŒ
æééæµããããã¢ã«ã³ãŒã«ãé€å»ããŠé ¢é žãšã
ã«ã§æŽæµãæ°Žçžãå¡©é žã§é žæ§ã«ãããæåºç©ã
å¥ãæ°ŽæŽä¹Ÿç¥ããã
ãïœïŒïœ ããªãã»ãã³âïŒâé ¢é ž å·¥çšïŒ€ã®ãããªã«2.0ïœã30c.c.ã®20ïŒ æ°Žé žåã
ããªãŠã 溶液åã³30c.c.ã®ãšã¿ããŒã«æ··åç©äžã§ïŒ
æééæµããããã¢ã«ã³ãŒã«ãé€å»ããŠé ¢é žãšã
ã«ã§æŽæµãæ°Žçžãå¡©é žã§é žæ§ã«ãããæåºç©ã
å¥ãæ°ŽæŽä¹Ÿç¥ããã
å·¥çšïŒŠïŒïŒïŒ11âãžãããâ11âãªããœãžãã³ãº
ãïœïŒïœ ããªãã»ãã³âïŒâã¢ã»ã¿ãã å·¥çšïŒ¥ã®é ž5.0ïœåã³å¡©åããªãã«40mlã®æ··å
ç©ã20åééæµããããç空äžã«èžçºä¹Ÿåºããã
30mlãã€ã®åå¡©åççŽ ãçšããŠïŒåºŠèžçºãè¡ãã
æ®æž£ã20mlã®ããã©ããããã©ã³ã«æº¶è§£ãããã®
溶液ãå·åŽãããæ¹æããã60mlã®ããã©ãã€ã
ããã©ã³ã¢ã³ã¢ãã¢é£œå©æº¶æ¶²ïŒæ°·æµŽïŒã«æ»Žäžã
ãããããŠåæã«ãã¢ã³ã¢ãã¢ã溶液äžãééã
ããã宀枩ã«ãããŠãæŽã«æ¹æã15åéç¶ããã
æ··åç©ãèžçºä¹Ÿåºãã12mlã®ãšã¿ããŒã«ãš60mlã®
æ°Žã®æ··åç©ãæ·»å ããæžæ¿æ¶²ã30åéæ¹æããã
åºäœãåé¢ããæ°Žã次ãã§ãšã¿ããŒã«ãæåŸã«ãš
ãŒãã«ã§æŽæµãç®ççæç©ãåŸãã
ãïœïŒïœ ããªãã»ãã³âïŒâã¢ã»ã¿ãã å·¥çšïŒ¥ã®é ž5.0ïœåã³å¡©åããªãã«40mlã®æ··å
ç©ã20åééæµããããç空äžã«èžçºä¹Ÿåºããã
30mlãã€ã®åå¡©åççŽ ãçšããŠïŒåºŠèžçºãè¡ãã
æ®æž£ã20mlã®ããã©ããããã©ã³ã«æº¶è§£ãããã®
溶液ãå·åŽãããæ¹æããã60mlã®ããã©ãã€ã
ããã©ã³ã¢ã³ã¢ãã¢é£œå©æº¶æ¶²ïŒæ°·æµŽïŒã«æ»Žäžã
ãããããŠåæã«ãã¢ã³ã¢ãã¢ã溶液äžãééã
ããã宀枩ã«ãããŠãæŽã«æ¹æã15åéç¶ããã
æ··åç©ãèžçºä¹Ÿåºãã12mlã®ãšã¿ããŒã«ãš60mlã®
æ°Žã®æ··åç©ãæ·»å ããæžæ¿æ¶²ã30åéæ¹æããã
åºäœãåé¢ããæ°Žã次ãã§ãšã¿ããŒã«ãæåŸã«ãš
ãŒãã«ã§æŽæµãç®ççæç©ãåŸãã
å·¥çšïŒ§ïŒïŒâïŒïŒâããããã·âÎ3âãããªã³â
ïŒïŒïŒâãžãªã³âïŒâã€ã«ïŒâïŒïŒ11âãžãã
ãâ11âãªããœãžãã³ãºãïœïŒïœ ããªãã»ãã³ å·¥çšïŒŠã®ã¢ãã5.118ïœãã·ãŠãŠé žãžãšãã«
2.939ïœãã«ãªãŠã ïœâãããã·ã4.723ïœåã³ãž
ã¡ãã«ãã«ã ã¢ãã40mlã®æ··åç©ã宀枩ã«ãããŠ
ïŒæéæ¹æãããåå¿æ¶²ã300mlã®æ°·æ°Žäžã«æ³šãã
300mlã®é ¢é žãšãã«ã§æœåºãè¡ãªãã6Nå¡©é žã§é ž
æ§ã«ããŠãé ¢é žãšãã«ã§æœåºãè¡ãã飜åå¡©åã
ããªãŠã 溶液ã§æŽæµããŠä¹Ÿç¥ããããèžçºä¹Ÿåºã
ãŠãæ®æž£ãæž©ãããžãªããµã³ã«æº¶è§£ãããããã
éå°ã®ã¢ã³ã¢ãã¢ã§åŠçããåºäœãå¥ããããž
ãªããµã³ã§æŽæµããŠä¹Ÿç¥ããããçæç©ãæ°Žã«æž
æ¿ããã6Nå¡©é žã§é žæ§ã«ããŠé ¢é žãšãã«ã§æœåº
ãè¡ããæœåºç©ã飜åå¡©åãããªãŠã 溶液ã§æŽæµ
ããç¡«é žãã°ãã·ãŠã äžã§ä¹Ÿç¥ãããèžçºãè¡ã€
ãŠç®ççæç©ãåŸãã
ïŒïŒïŒâãžãªã³âïŒâã€ã«ïŒâïŒïŒ11âãžãã
ãâ11âãªããœãžãã³ãºãïœïŒïœ ããªãã»ãã³ å·¥çšïŒŠã®ã¢ãã5.118ïœãã·ãŠãŠé žãžãšãã«
2.939ïœãã«ãªãŠã ïœâãããã·ã4.723ïœåã³ãž
ã¡ãã«ãã«ã ã¢ãã40mlã®æ··åç©ã宀枩ã«ãããŠ
ïŒæéæ¹æãããåå¿æ¶²ã300mlã®æ°·æ°Žäžã«æ³šãã
300mlã®é ¢é žãšãã«ã§æœåºãè¡ãªãã6Nå¡©é žã§é ž
æ§ã«ããŠãé ¢é žãšãã«ã§æœåºãè¡ãã飜åå¡©åã
ããªãŠã 溶液ã§æŽæµããŠä¹Ÿç¥ããããèžçºä¹Ÿåºã
ãŠãæ®æž£ãæž©ãããžãªããµã³ã«æº¶è§£ãããããã
éå°ã®ã¢ã³ã¢ãã¢ã§åŠçããåºäœãå¥ããããž
ãªããµã³ã§æŽæµããŠä¹Ÿç¥ããããçæç©ãæ°Žã«æž
æ¿ããã6Nå¡©é žã§é žæ§ã«ããŠé ¢é žãšãã«ã§æœåº
ãè¡ããæœåºç©ã飜åå¡©åãããªãŠã 溶液ã§æŽæµ
ããç¡«é žãã°ãã·ãŠã äžã§ä¹Ÿç¥ãããèžçºãè¡ã€
ãŠç®ççæç©ãåŸãã
å®æœäŸ 10
ïŒïŒ11âãžãããâ11âãªããœãžãã³ãºãïœïŒ
ïœ ããªãã»ãã³âïŒâã«ã«ãã³é žã¡ãã«ãšã¹ã
ã« å·¥çšïŒ¡ïŒïŒâã¯ããã«ã«ããã«âïŒïŒ11âãžãã
ãâ11âãªããœãžãã³ãºãïœïŒïœ ããªãã»ãã³ ïŒïŒ11âãžãããâ11âãªããœãžãã³ãºãïœïŒ
ïœ ããªãã»ãã³âïŒâã«ã«ãã³é ž5.16ïœã100c.c.
ã®ã¯ãããã«ã åã³50c.c.ã®å¡©åããªãã«äžã«æº¶è§£
ããæ··åç©ã«1.0c.c.ã®ãžã¡ãã«ãã«ã ã¢ãããæ·»
å ãããæ··åç©ã宀枩ã«ãããŠ72æéæŸçœ®ããã
æ··åç©ãèžçºä¹ŸåºãããŠç®çé žã¯ãã©ã€ããåŸ
ãã
ïœ ããªãã»ãã³âïŒâã«ã«ãã³é žã¡ãã«ãšã¹ã
ã« å·¥çšïŒ¡ïŒïŒâã¯ããã«ã«ããã«âïŒïŒ11âãžãã
ãâ11âãªããœãžãã³ãºãïœïŒïœ ããªãã»ãã³ ïŒïŒ11âãžãããâ11âãªããœãžãã³ãºãïœïŒ
ïœ ããªãã»ãã³âïŒâã«ã«ãã³é ž5.16ïœã100c.c.
ã®ã¯ãããã«ã åã³50c.c.ã®å¡©åããªãã«äžã«æº¶è§£
ããæ··åç©ã«1.0c.c.ã®ãžã¡ãã«ãã«ã ã¢ãããæ·»
å ãããæ··åç©ã宀枩ã«ãããŠ72æéæŸçœ®ããã
æ··åç©ãèžçºä¹ŸåºãããŠç®çé žã¯ãã©ã€ããåŸ
ãã
å·¥çšïŒ¢ïŒïŒïŒ11âãžãããâ11âãªããœãžãã³ãº
ãïœïŒïœ ããªãã»ãã³âïŒâã«ã«ãã³é žã¡ãã«
ãšã¹ãã« å·¥çšïŒ¡ã®é žã¯ãã©ã€ã2.0ïœã®1.0c.c.ã®ã¡ã¿ããŒ
ã«åã³ïŒc.c.ã®ããªãžã³ãå«æããããã©ãããã
ã©ã³20c.c.äžã«æº¶è§£ãããæ··åç©ã宀枩ã«ãããŠ24
æéæŸçœ®ãã次ãã§èžçºä¹Ÿåºããããæ®æž£ãïŒïŒ
ïŒã®ãšãŒãã«ïŒãããµã³ã«æº¶è§£ãã·ãªã«ã²ã«ãé
ããŠéãããã液ãèžçºä¹ŸåºããŠç®ççæç©
ãåŸãã
ãïœïŒïœ ããªãã»ãã³âïŒâã«ã«ãã³é žã¡ãã«
ãšã¹ãã« å·¥çšïŒ¡ã®é žã¯ãã©ã€ã2.0ïœã®1.0c.c.ã®ã¡ã¿ããŒ
ã«åã³ïŒc.c.ã®ããªãžã³ãå«æããããã©ãããã
ã©ã³20c.c.äžã«æº¶è§£ãããæ··åç©ã宀枩ã«ãããŠ24
æéæŸçœ®ãã次ãã§èžçºä¹Ÿåºããããæ®æž£ãïŒïŒ
ïŒã®ãšãŒãã«ïŒãããµã³ã«æº¶è§£ãã·ãªã«ã²ã«ãé
ããŠéãããã液ãèžçºä¹ŸåºããŠç®ççæç©
ãåŸãã
å®æœäŸ16ã®æ¹æ³ãçšããå·¥çšïŒ¢ã®ã¡ã¿ããŒã«ã®
代ãã«ãäŸãã°ããšã¿ããŒã«ãïŒâãããããŒ
ã«ãïœâãã¿ããŒã«åã³ïŒâãã¿ããŒã«ã®ãããª
å¥ã®äœçŽã¢ã«ã«ããŒã«ãçšããŠå¯Ÿå¿ããïŒïŒ11â
ãžãããâ11âãªããœãžãã³ãºãïœïŒïœ ããªãã»
ãã³âïŒâã«ã«ãã³é žã®äœçŽã¢ã«ãã«ãšã¹ãã«ã
åŸãããã
代ãã«ãäŸãã°ããšã¿ããŒã«ãïŒâãããããŒ
ã«ãïœâãã¿ããŒã«åã³ïŒâãã¿ããŒã«ã®ãããª
å¥ã®äœçŽã¢ã«ã«ããŒã«ãçšããŠå¯Ÿå¿ããïŒïŒ11â
ãžãããâ11âãªããœãžãã³ãºãïœïŒïœ ããªãã»
ãã³âïŒâã«ã«ãã³é žã®äœçŽã¢ã«ãã«ãšã¹ãã«ã
åŸãããã
å®æœäŸ 11
ïŒïŒ11âãžãããâ11âãªããœãžãã³ãºãïœïŒ
ïœ ããªãã»ãã³âïŒâã«ã«ãã³é žã¡ãã«ãšã¹ã
ã« å®æœäŸ10ã®å·¥çšïŒ¡ã®ïŒïŒ11âãžãããâ11âãª
ããœãžãã³ãºãïœïŒïœ ããªãã»ãã³âïŒâã«ã«ã
ã³é žã®ä»£ãã«ïŒïŒ11âãžãããâ11âãªããœãžã
ã³ãºãïœïŒïœ ããªãã»ãã³âïŒâã«ã«ãã³é žãçš
ããŠå®æœäŸ10ã®æ¹æ³ãç¹°è¿ããŠç®ççæç©ãåŸ
ããå¿ èŠã«å¿ããŠãäŸãã°ãšã¿ããŒã«ãïŒâãã
ãããŒã«ããã¿ããŒã«åã³ïŒâãã¿ããŒã«ã®ãã
ãªä»ã®äœçŽã¢ã«ã«ããŒã«ãå·¥çšïŒ¢ã®ã¡ã¿ããŒã«ã®
代ãã«çšããããšã«ãã察å¿ããïŒïŒ11âãžãã
ãâ11âãªããœãžãã³ãºãïœïŒïœ ããªãã»ãã³â
ïŒâã«ã«ãã³é žã®äœçŽã¢ã«ãã«ãšã¹ãã«ãåŸãã
ãã
ïœ ããªãã»ãã³âïŒâã«ã«ãã³é žã¡ãã«ãšã¹ã
ã« å®æœäŸ10ã®å·¥çšïŒ¡ã®ïŒïŒ11âãžãããâ11âãª
ããœãžãã³ãºãïœïŒïœ ããªãã»ãã³âïŒâã«ã«ã
ã³é žã®ä»£ãã«ïŒïŒ11âãžãããâ11âãªããœãžã
ã³ãºãïœïŒïœ ããªãã»ãã³âïŒâã«ã«ãã³é žãçš
ããŠå®æœäŸ10ã®æ¹æ³ãç¹°è¿ããŠç®ççæç©ãåŸ
ããå¿ èŠã«å¿ããŠãäŸãã°ãšã¿ããŒã«ãïŒâãã
ãããŒã«ããã¿ããŒã«åã³ïŒâãã¿ããŒã«ã®ãã
ãªä»ã®äœçŽã¢ã«ã«ããŒã«ãå·¥çšïŒ¢ã®ã¡ã¿ããŒã«ã®
代ãã«çšããããšã«ãã察å¿ããïŒïŒ11âãžãã
ãâ11âãªããœãžãã³ãºãïœïŒïœ ããªãã»ãã³â
ïŒâã«ã«ãã³é žã®äœçŽã¢ã«ãã«ãšã¹ãã«ãåŸãã
ãã
å®æœäŸ 12
ïŒïŒ11âãžãããâ11âãªããœãžãã³ãºãïœïŒ
ïœ ããªãã»ãã³âïŒâã«ã«ãããµãã å·¥çšïŒ¡ïŒïŒâã¯ããã«ã«ããã«âïŒïŒ11âãžãã
ãâ11âãªããœãžãã³ãºãïœïŒïœ ããªãã»ãã³ ïŒïœã®ïŒïŒ11âãžãããâ11âãªããœãžãã³ãº
ãïœïŒïœ ããªãã»ãã³âïŒâã«ã«ãã³é žåã³40ml
ã®å¡©åããªãã«ã®æº¶æ¶²ã20åéå ç±éæµãããã
åå¿æ¶²ãç空äžã«èžçºä¹Ÿåºããããèžçºã¯30mlã
ã€ã®åå¡©åççŽ ãçšããŠïŒåºŠç¹°è¿ããããæ®æž£ã
ãžã€ãœãããã«ãšãŒãã«ããçµæ¶åãããŠç®çç
æç©ãåŸãã
ïœ ããªãã»ãã³âïŒâã«ã«ãããµãã å·¥çšïŒ¡ïŒïŒâã¯ããã«ã«ããã«âïŒïŒ11âãžãã
ãâ11âãªããœãžãã³ãºãïœïŒïœ ããªãã»ãã³ ïŒïœã®ïŒïŒ11âãžãããâ11âãªããœãžãã³ãº
ãïœïŒïœ ããªãã»ãã³âïŒâã«ã«ãã³é žåã³40ml
ã®å¡©åããªãã«ã®æº¶æ¶²ã20åéå ç±éæµãããã
åå¿æ¶²ãç空äžã«èžçºä¹Ÿåºããããèžçºã¯30mlã
ã€ã®åå¡©åççŽ ãçšããŠïŒåºŠç¹°è¿ããããæ®æž£ã
ãžã€ãœãããã«ãšãŒãã«ããçµæ¶åãããŠç®çç
æç©ãåŸãã
å·¥çšïŒ¢ïŒïŒïŒ11âãžãããâ11âãªããœãžãã³ãº
ãïœïŒïœ ããªãã»ãã³âïŒâã«ã«ãããµãã å·¥çšïŒ¡ã®é žã¯ãã©ã€ãã20mlã®ä¹Ÿç¥ããã©ãã
ããã©ã³ã«æº¶è§£ã溶液ãæ¹æããªããå·åŽããã
ïŒæ°·æµŽïŒ60mlã®ããã©ããããã©ã³ã®ã¢ã³ã¢ãã¢
飜å溶液ã«æ»Žäžãããåæã«åå¿æ¶²äžã«ã¯15åé
ã¢ã³ã¢ãã¢ãéããã宀枩ã«ãããŠæŽã«15åéæ¹
æåŸãåå¿æ¶²ãèžçºä¹Ÿåºããã12mlã®ãšã¿ããŒã«
åã³60mlã®æ°Žã®æ··åç©ãæ®æž£ã«æ·»å ãã宀枩ã«ã
ããŠæŽã«30åéæ¹æãããåºäœãå¥ãã氎次ã
ã§ãšã¿ããŒã«ãæŽã«ãšãŒãã«ã§æŽæµãããç空äž
ã§ä¹Ÿç¥ãããŠç®ççæç©ãåŸãã
ãïœïŒïœ ããªãã»ãã³âïŒâã«ã«ãããµãã å·¥çšïŒ¡ã®é žã¯ãã©ã€ãã20mlã®ä¹Ÿç¥ããã©ãã
ããã©ã³ã«æº¶è§£ã溶液ãæ¹æããªããå·åŽããã
ïŒæ°·æµŽïŒ60mlã®ããã©ããããã©ã³ã®ã¢ã³ã¢ãã¢
飜å溶液ã«æ»Žäžãããåæã«åå¿æ¶²äžã«ã¯15åé
ã¢ã³ã¢ãã¢ãéããã宀枩ã«ãããŠæŽã«15åéæ¹
æåŸãåå¿æ¶²ãèžçºä¹Ÿåºããã12mlã®ãšã¿ããŒã«
åã³60mlã®æ°Žã®æ··åç©ãæ®æž£ã«æ·»å ãã宀枩ã«ã
ããŠæŽã«30åéæ¹æãããåºäœãå¥ãã氎次ã
ã§ãšã¿ããŒã«ãæŽã«ãšãŒãã«ã§æŽæµãããç空äž
ã§ä¹Ÿç¥ãããŠç®ççæç©ãåŸãã
åæ§ã«ããŠãå·¥çšïŒ¡ã®ïŒïŒ11âãžãããâ11â
ãªããœãžãã³ãºãïœïŒïœ ããªãã»ãã³âïŒâã«ã«
ãã³é žã®ä»£ãã«ïŒïŒ11âãžãããâ11âãªããœãž
ãã³ãºãïœïŒïœ ããªãã»ãã³âïŒâã«ã«ãã³é žã
çšããããšã«ããïŒïŒ11âãžãããâ11âãªããœ
ãžãã³ãºãïœïŒïœ ããªãã»ãã³âïŒâã«ã«ãããµ
ãããåŸãããã
ãªããœãžãã³ãºãïœïŒïœ ããªãã»ãã³âïŒâã«ã«
ãã³é žã®ä»£ãã«ïŒïŒ11âãžãããâ11âãªããœãž
ãã³ãºãïœïŒïœ ããªãã»ãã³âïŒâã«ã«ãã³é žã
çšããããšã«ããïŒïŒ11âãžãããâ11âãªããœ
ãžãã³ãºãïœïŒïœ ããªãã»ãã³âïŒâã«ã«ãããµ
ãããåŸãããã
å®æœäŸ 13
ïŒïŒ11âãžãããâ11âãªããœãžãã³ãºãïœïŒ
ïœ ããªãã»ãã³âïŒââã¡ãã«ã«ã«ãããµã
ã 6.0ïœã®ïŒâã¯ããã«ã«ããã«âïŒïŒ11âãžã
ããâ11âãªããœãžãã³ãºãïœïŒïœ ããªãã»ãã³
ãå¡©åã¡ãã¬ã³100mläžã®ã¡ãã«ã¢ãã³ïŒïœã«ïŒ
ãïŒâã«ãããŠæ·»å ããã13mlã®ããªãšãã«ã¢ã
ã³ã10åéã«äºã€ãŠæ·»å ããåŸãåå¿æ¶²ã宀枩ã«
ãããŠäžæ©æ¹æãããåå¿æ¶²ãæ°Žã§æœåºããææ©
å±€ã也ç¥ããŠèžçºä¹Ÿåºããã200ïŒ20ã®ãã«ãš
ã³ïŒãžãªããµã³ã§æº¶é¢ãããŠã·ãªã«ã²ã«äžã§ã¯ã
ããã°ã©ããè¡ãã溶é¢æ¶²ãèžçºä¹Ÿåºããã¡ã¿ã
ãŒã«ããæ®æž£ãåçµæ¶ãããŠç®ççæç©ãåŸãã
ïœ ããªãã»ãã³âïŒââã¡ãã«ã«ã«ãããµã
ã 6.0ïœã®ïŒâã¯ããã«ã«ããã«âïŒïŒ11âãžã
ããâ11âãªããœãžãã³ãºãïœïŒïœ ããªãã»ãã³
ãå¡©åã¡ãã¬ã³100mläžã®ã¡ãã«ã¢ãã³ïŒïœã«ïŒ
ãïŒâã«ãããŠæ·»å ããã13mlã®ããªãšãã«ã¢ã
ã³ã10åéã«äºã€ãŠæ·»å ããåŸãåå¿æ¶²ã宀枩ã«
ãããŠäžæ©æ¹æãããåå¿æ¶²ãæ°Žã§æœåºããææ©
å±€ã也ç¥ããŠèžçºä¹Ÿåºããã200ïŒ20ã®ãã«ãš
ã³ïŒãžãªããµã³ã§æº¶é¢ãããŠã·ãªã«ã²ã«äžã§ã¯ã
ããã°ã©ããè¡ãã溶é¢æ¶²ãèžçºä¹Ÿåºããã¡ã¿ã
ãŒã«ããæ®æž£ãåçµæ¶ãããŠç®ççæç©ãåŸãã
äžèšã§çšããã¡ãã«ã¢ãã³ã®ä»£ãã«å¥ã®ïŒ®âäœ
çŽã¢ã«ãã«ã¢ãã³ãäŸãã°ãšãã«ã¢ãã³ãããã«
ã¢ãã³ãã€ãœãããã«ã¢ãã³ãããã«ã¢ãã³ãªã©
ãããã¯ïŒ®ïŒïŒ®âãžâäœçŽã¢ã«ãã«ã¢ãã³ãäŸã
ã°ããžã¡ãã«ã¢ãã³ããžãšãã«ã¢ãã³ããžããã
ã«ã¢ãã³ããžããã«ã¢ãã³ãªã©ãçšããä»ã¯åæ§
ã«ããŠå¯Ÿå¿ããïŒïŒ11âãžãããâ11âãªããœãž
ãã³ãºãïœïŒïœ ããªãã»ãã³âïŒââäœçŽã¢ã«
ãã«ã«ã«ãããµãããããã¯ïŒâïŒïŒ®âãžâäœ
çŽã¢ã«ãã«ã«ã«ãããµãããåŸããããåãäžèš
ã§çšããïŒâã¯ããã«ã«ããã«âïŒïŒ11âãžãã
ãâ11âãªããœãžãã³ãºãïœïŒïœ ããªãã»ãã³ã®
代ãã«ïŒâã¯ããã«ã«ããã«âïŒïŒ11âãžããã
â11âãªããœãžãã³ãºãïœïŒïœ ããªãã»ãã³ãçš
ããããšã«ãã察å¿ããïŒïŒ11âãžãããâ11â
ãªããœãžãã³ãºãïœïŒïœ ããªãã»ãã³âïŒâã«ã«
ãããµãããïŒââäœçŽã¢ã«ãã«ã«ã«ãããµã
ãåã³ïŒâïŒïŒ®âãžâäœçŽã¢ã«ãã«ã«ã«ãããµ
ãããåŸãããã
çŽã¢ã«ãã«ã¢ãã³ãäŸãã°ãšãã«ã¢ãã³ãããã«
ã¢ãã³ãã€ãœãããã«ã¢ãã³ãããã«ã¢ãã³ãªã©
ãããã¯ïŒ®ïŒïŒ®âãžâäœçŽã¢ã«ãã«ã¢ãã³ãäŸã
ã°ããžã¡ãã«ã¢ãã³ããžãšãã«ã¢ãã³ããžããã
ã«ã¢ãã³ããžããã«ã¢ãã³ãªã©ãçšããä»ã¯åæ§
ã«ããŠå¯Ÿå¿ããïŒïŒ11âãžãããâ11âãªããœãž
ãã³ãºãïœïŒïœ ããªãã»ãã³âïŒââäœçŽã¢ã«
ãã«ã«ã«ãããµãããããã¯ïŒâïŒïŒ®âãžâäœ
çŽã¢ã«ãã«ã«ã«ãããµãããåŸããããåãäžèš
ã§çšããïŒâã¯ããã«ã«ããã«âïŒïŒ11âãžãã
ãâ11âãªããœãžãã³ãºãïœïŒïœ ããªãã»ãã³ã®
代ãã«ïŒâã¯ããã«ã«ããã«âïŒïŒ11âãžããã
â11âãªããœãžãã³ãºãïœïŒïœ ããªãã»ãã³ãçš
ããããšã«ãã察å¿ããïŒïŒ11âãžãããâ11â
ãªããœãžãã³ãºãïœïŒïœ ããªãã»ãã³âïŒâã«ã«
ãããµãããïŒââäœçŽã¢ã«ãã«ã«ã«ãããµã
ãåã³ïŒâïŒïŒ®âãžâäœçŽã¢ã«ãã«ã«ã«ãããµ
ãããåŸãããã
æŽã«åãåæ§ã«ããŠãäŸãã°ã°ãªã·ã³ãããª
ã³ããã€ã·ã³ãã€ãœãã€ã·ã³ãªã©ã®ã«ã«ããã·äœ
çŽã¢ã«ãã«ã¢ãã³ãããã¯ãäŸãã°ïŒ®âã¡ãã«ã°
ãªã·ã³ãâãããã«ãã€ã·ã³ãâããã«ã€ãœ
ãã€ã·ã³ãªã©ã®ãã®ïŒ®âäœçŽã¢ã«ãã«èªå°äœã眮
æããããšã«ãã€ãŠå¯Ÿå¿ããïŒïŒ11âãžãããâ
11âãªããœãžãã³ãºãïœïŒïœ ããªãã»ãã³âïŒ
ïŒåã¯ïŒïŒâã«ã«ããã·äœçŽã¢ã«ãã«ã«ã«ãããµã
ããããã¯ãã®ïŒ®âäœçŽã¢ã«ãã«èªå°äœãåŸãã
ãã
ã³ããã€ã·ã³ãã€ãœãã€ã·ã³ãªã©ã®ã«ã«ããã·äœ
çŽã¢ã«ãã«ã¢ãã³ãããã¯ãäŸãã°ïŒ®âã¡ãã«ã°
ãªã·ã³ãâãããã«ãã€ã·ã³ãâããã«ã€ãœ
ãã€ã·ã³ãªã©ã®ãã®ïŒ®âäœçŽã¢ã«ãã«èªå°äœã眮
æããããšã«ãã€ãŠå¯Ÿå¿ããïŒïŒ11âãžãããâ
11âãªããœãžãã³ãºãïœïŒïœ ããªãã»ãã³âïŒ
ïŒåã¯ïŒïŒâã«ã«ããã·äœçŽã¢ã«ãã«ã«ã«ãããµã
ããããã¯ãã®ïŒ®âäœçŽã¢ã«ãã«èªå°äœãåŸãã
ãã
å®æœäŸ 14
âã¡ã¿ã³ã¹ã«ããã«ïŒïŒ11âãžãããâ11â
ãªããœãžãã³ãºãïœïŒïœ ããªãã»ãã³âïŒâã«
ã«ãããµãã 5.0ïœã®ïŒïŒ11âãžãããâ11âãªããœãžãã³
ãºãïœïŒïœ ããªãã»ãã³âïŒâã«ã«ãã³é žã50c.c.
ã®å¡©åããªãã«äžã§15åéå ç±éæµããåŸãéå°
ã®å¡©åããªãã«ãçå»ãããæ®æž£ãå°éã®ãã³ãŒ
ã³ãçšããŠïŒåèžçºããããåŸãããé žã¯ãã©ã€
ããå¡©åã¡ãã¬ã³100mläžã®ã¡ã¿ã³ã¹ã«ãã³ã¢ã
ã4.0ïœã«ïŒãïŒâã«ãããŠæ·»å ããã15mlã®ã
ãªãšãã«ã¢ãã³ã10åéã«äºã€ãŠæ»Žäžãããæ··å
ç©ã宀枩ã«ãããŠäžæ©æ¹æãããåå¿æ¶²ã100c.c.
ã®0.5Næ°Žé žåãããªãŠã ã§æœåºããã¢ã«ã«ãªæ§
æœåºç©ããšãŒãã«ã§æŽæµã6Nå¡©é žã§é žæ§ã«ããã
åºåœ¢åãå¥ãç空äžã§æ°Žé žåã«ãªãŠã äžã§ä¹Ÿç¥
ãããã200ïŒ20ïŒïŒã®ãã«ãšã³ïŒãžãªããµã³ïŒ
é ¢é žã§æº¶é¢ãããŠã·ãªã«ã²ã«äžã§ã¯ãããã°ã©ã
ãè¡ãã溶é¢æ¶²ãèžçºä¹Ÿåºãããæ®æž£ãã¡ã¿ããŒ
ã«ããåçµæ¶åããç®ççæç©ãåŸãã
ãªããœãžãã³ãºãïœïŒïœ ããªãã»ãã³âïŒâã«
ã«ãããµãã 5.0ïœã®ïŒïŒ11âãžãããâ11âãªããœãžãã³
ãºãïœïŒïœ ããªãã»ãã³âïŒâã«ã«ãã³é žã50c.c.
ã®å¡©åããªãã«äžã§15åéå ç±éæµããåŸãéå°
ã®å¡©åããªãã«ãçå»ãããæ®æž£ãå°éã®ãã³ãŒ
ã³ãçšããŠïŒåèžçºããããåŸãããé žã¯ãã©ã€
ããå¡©åã¡ãã¬ã³100mläžã®ã¡ã¿ã³ã¹ã«ãã³ã¢ã
ã4.0ïœã«ïŒãïŒâã«ãããŠæ·»å ããã15mlã®ã
ãªãšãã«ã¢ãã³ã10åéã«äºã€ãŠæ»Žäžãããæ··å
ç©ã宀枩ã«ãããŠäžæ©æ¹æãããåå¿æ¶²ã100c.c.
ã®0.5Næ°Žé žåãããªãŠã ã§æœåºããã¢ã«ã«ãªæ§
æœåºç©ããšãŒãã«ã§æŽæµã6Nå¡©é žã§é žæ§ã«ããã
åºåœ¢åãå¥ãç空äžã§æ°Žé žåã«ãªãŠã äžã§ä¹Ÿç¥
ãããã200ïŒ20ïŒïŒã®ãã«ãšã³ïŒãžãªããµã³ïŒ
é ¢é žã§æº¶é¢ãããŠã·ãªã«ã²ã«äžã§ã¯ãããã°ã©ã
ãè¡ãã溶é¢æ¶²ãèžçºä¹Ÿåºãããæ®æž£ãã¡ã¿ããŒ
ã«ããåçµæ¶åããç®ççæç©ãåŸãã
äžèšã§çšããã¡ã¿ã³ã¹ã«ãã³ã¢ããã®ä»£ãã«å¥
ã®äœçŽã¢ã«ãã«ã¹ã«ãã³ã¢ãããªã©ãäŸãã°ãšã¿
ã³ã¹ã«ãã³ã¢ããããããã³ã¹ã«ãã³ã¢ãããã
ã¿ã³ã¹ã«ãã³ã¢ãããªã©ãçšããä»ã¯åæ§ã«ããŠ
察å¿ããâäœçŽã¢ã«ãã«ã¹ã«ããã«ïŒïŒ11âãž
ãããâ11âãªããœãžãã³ãºãïœïŒïœ ããªãã»ã
ã³âïŒâã«ã«ãããµãããåŸããããåãäžèšã§
çšããïŒïŒ11âãžãããâ11âãªããœãžãã³ãº
ãïœïŒïœ ããªãã»ãã³âïŒâã«ã«ãã³é žã®ä»£ãã«
ïŒïŒ11âãžãããâ11âãªããœãžãã³ãºãïœïŒ
ïœ ããªãã»ãã³âïŒâã«ã«ãã³é žãçšããããšã«
ãã察å¿ããïŒïŒ11âãžãããâ11âãªããœãžã
ã³ãºãïœïŒïœ ããªãã»ãã³âïŒââäœçŽã¢ã«ã
ã«ã¹ã«ããã«ã«ã«ãããµãããåŸãããã
ã®äœçŽã¢ã«ãã«ã¹ã«ãã³ã¢ãããªã©ãäŸãã°ãšã¿
ã³ã¹ã«ãã³ã¢ããããããã³ã¹ã«ãã³ã¢ãããã
ã¿ã³ã¹ã«ãã³ã¢ãããªã©ãçšããä»ã¯åæ§ã«ããŠ
察å¿ããâäœçŽã¢ã«ãã«ã¹ã«ããã«ïŒïŒ11âãž
ãããâ11âãªããœãžãã³ãºãïœïŒïœ ããªãã»ã
ã³âïŒâã«ã«ãããµãããåŸããããåãäžèšã§
çšããïŒïŒ11âãžãããâ11âãªããœãžãã³ãº
ãïœïŒïœ ããªãã»ãã³âïŒâã«ã«ãã³é žã®ä»£ãã«
ïŒïŒ11âãžãããâ11âãªããœãžãã³ãºãïœïŒ
ïœ ããªãã»ãã³âïŒâã«ã«ãã³é žãçšããããšã«
ãã察å¿ããïŒïŒ11âãžãããâ11âãªããœãžã
ã³ãºãïœïŒïœ ããªãã»ãã³âïŒââäœçŽã¢ã«ã
ã«ã¹ã«ããã«ã«ã«ãããµãããåŸãããã
å®æœäŸ 15
âïŒâã¡ãã«âïŒâãã¢ãŸãªãžããªãžã³ïŒïŒ
11âãžãããâ11âãªããœãžãã³ãºãïœïŒïœ ã
ãªãã»ãã³âïŒâã«ã«ãããµãã 1.041ïœã®ïŒïŒ11âãžãããâ11âãªããœãžã
ã³ãºãïœïŒïœ ããªãã»ãã³âïŒâã«ã«ãã³é žã15
c.c.ã®å¡©åããªãã«äžã§30åééæµããããåå¿æ¶²
ããæ®çºåãé€å»ããŠä¹Ÿåºããæ®æž£ã25c.c.ã®å¡©å
ã¡ãã¬ã³ã«æº¶è§£ãããïŒâã€ããâïŒâã¡ãã«ã
ã¢ãŸãªãžã³1.0ïœã®å¡©åã¡ãã¬ã³10c.c.ã®æº¶æ¶²ãæ·»
å ããã宀枩ã§30åéæ¹æåŸãæ°Žãæ·»å ãããæŽ
ã«10åéæ¹æãç¶ãããææ©çžãåé¢ããŠæ°ŽæŽ
ããç¡«é žãããªãŠã äžã§äžæ©ä¹Ÿç¥ããããæ®çºå
ãé€å»ããŠä¹Ÿåºããããæ®æž£ããšãŒãã«äžã§æ¬¡ã
ã§ã¡ã¿ããŒã«äžã§æ¹æç²ç ãããåŸãããåºäœã
20ïŒ é ¢é žãšãã«ãå«ããã³ãŒã³ã§æº¶é¢ãããŠã·ãª
ã«ã²ã«äžã§ã¯ãããã°ã©ããè¡ããèžçºä¹Ÿåºãã
ãŠç®ççæç©ãåŸãïŒèç¹168ã168âïŒã
11âãžãããâ11âãªããœãžãã³ãºãïœïŒïœ ã
ãªãã»ãã³âïŒâã«ã«ãããµãã 1.041ïœã®ïŒïŒ11âãžãããâ11âãªããœãžã
ã³ãºãïœïŒïœ ããªãã»ãã³âïŒâã«ã«ãã³é žã15
c.c.ã®å¡©åããªãã«äžã§30åééæµããããåå¿æ¶²
ããæ®çºåãé€å»ããŠä¹Ÿåºããæ®æž£ã25c.c.ã®å¡©å
ã¡ãã¬ã³ã«æº¶è§£ãããïŒâã€ããâïŒâã¡ãã«ã
ã¢ãŸãªãžã³1.0ïœã®å¡©åã¡ãã¬ã³10c.c.ã®æº¶æ¶²ãæ·»
å ããã宀枩ã§30åéæ¹æåŸãæ°Žãæ·»å ãããæŽ
ã«10åéæ¹æãç¶ãããææ©çžãåé¢ããŠæ°ŽæŽ
ããç¡«é žãããªãŠã äžã§äžæ©ä¹Ÿç¥ããããæ®çºå
ãé€å»ããŠä¹Ÿåºããããæ®æž£ããšãŒãã«äžã§æ¬¡ã
ã§ã¡ã¿ããŒã«äžã§æ¹æç²ç ãããåŸãããåºäœã
20ïŒ é ¢é žãšãã«ãå«ããã³ãŒã³ã§æº¶é¢ãããŠã·ãª
ã«ã²ã«äžã§ã¯ãããã°ã©ããè¡ããèžçºä¹Ÿåºãã
ãŠç®ççæç©ãåŸãïŒèç¹168ã168âïŒã
å®æœäŸ 16
ïŒïŒ11âãžãããâ11âãªããœãžãã³ãºãïœïŒ
ïœ ããªãã»ãã³âïŒâã«ã«ãã³é žâβâããã
ãã·ãšãã«ãšã¹ãã« ïŒâã¯ããâã«ã«ããã«âïŒïŒ11âãžãããâ
11âãªããœâãžãã³ãºãïœïŒïœ ããªãã»ãã³1.0
ïœã®å¡©åã¡ãã¬ã³50c.c.ã®æº¶æ¶²ãæ¹æãããããã«
ãšãã¬ã³ã°ãªã³ãŒã«ïŒïœãæ·»å ãæ··åç©ã宀枩ã§
18æéæ¹æããã溶åªåã³éå°ã®ãšãã¬ã³ã°ãªã³
ãŒã«ãé«ç空äžïŒ0.1mmïŒã«ãããŠçå»ãããæ®
枣ã10ïŒ ã®é ¢é žãšãã«ãå«ããã³ãŒã³ã§çå»ãã
ãŠã·ãªã«ã²ã«ã«ã©ã ïŒ100ïœïŒäžã§ã¯ãããã°ã©
ããè¡ã€ãŠç®ççæç©ãåŸãã
ïœ ããªãã»ãã³âïŒâã«ã«ãã³é žâβâããã
ãã·ãšãã«ãšã¹ãã« ïŒâã¯ããâã«ã«ããã«âïŒïŒ11âãžãããâ
11âãªããœâãžãã³ãºãïœïŒïœ ããªãã»ãã³1.0
ïœã®å¡©åã¡ãã¬ã³50c.c.ã®æº¶æ¶²ãæ¹æãããããã«
ãšãã¬ã³ã°ãªã³ãŒã«ïŒïœãæ·»å ãæ··åç©ã宀枩ã§
18æéæ¹æããã溶åªåã³éå°ã®ãšãã¬ã³ã°ãªã³
ãŒã«ãé«ç空äžïŒ0.1mmïŒã«ãããŠçå»ãããæ®
枣ã10ïŒ ã®é ¢é žãšãã«ãå«ããã³ãŒã³ã§çå»ãã
ãŠã·ãªã«ã²ã«ã«ã©ã ïŒ100ïœïŒäžã§ã¯ãããã°ã©
ããè¡ã€ãŠç®ççæç©ãåŸãã
ãšãã¬ã³ã°ãªã³ãŒã«ã®ä»£ãã«ããªã¡ãã¬ã³ã°ãª
ã³ãŒã«åã³ïŒïŒïŒâãã¿ã³ãžãªãŒã«ãªã©ã®å¥ã®äœ
çŽã¢ã«ãã«ãžãªãŒã«ãçšããä»ã¯åæ§ã«ããŠå¯Ÿå¿
ããããããã·äœçŽã¢ã«ãã«ãšã¹ãã«ãåŸãã
ããåãäžèšã§äœ¿çšãããïŒâã¯ããã«ã«ããã«
ïŒïŒ11âãžãããâ11âãªããœãžãã³ãºãïœïŒ
ïœ ããªãã»ãã³ã®ä»£ãã«ïŒâã¯ããã«ã«ããã«
ïŒïŒ11âãžãããâ11âãªããœãžãã³ãºãïœïŒ
ïœ ããªãã»ãã³ãã察å¿ããããããã·äœçŽã¢ã«
ãã«ïŒâã«ã«ããã·ã¬ãŒããšã¹ãã«ãåŸãããã
ã³ãŒã«åã³ïŒïŒïŒâãã¿ã³ãžãªãŒã«ãªã©ã®å¥ã®äœ
çŽã¢ã«ãã«ãžãªãŒã«ãçšããä»ã¯åæ§ã«ããŠå¯Ÿå¿
ããããããã·äœçŽã¢ã«ãã«ãšã¹ãã«ãåŸãã
ããåãäžèšã§äœ¿çšãããïŒâã¯ããã«ã«ããã«
ïŒïŒ11âãžãããâ11âãªããœãžãã³ãºãïœïŒ
ïœ ããªãã»ãã³ã®ä»£ãã«ïŒâã¯ããã«ã«ããã«
ïŒïŒ11âãžãããâ11âãªããœãžãã³ãºãïœïŒ
ïœ ããªãã»ãã³ãã察å¿ããããããã·äœçŽã¢ã«
ãã«ïŒâã«ã«ããã·ã¬ãŒããšã¹ãã«ãåŸãããã
å®æœäŸ 17
ïŒïŒ11âãžãããâ11âãªããœãžãã³ãºãïœïŒ
ïœ ããªãã»ãã³âïŒâã«ã«ãã³é žâβâãžã¡ã
ã«ã¢ãããšãã«ãšã¹ãã« å®æœäŸ10ã®å·¥çšïŒ¡ã§äœãããïŒâã¯ããã«ã«ã
ãã«âïŒïŒ11âãžãããâ11âãªããœâãžãã³ãº
ãïœïŒïœ ããªãã»ãã³1.0ïœãæ¹æããªããç¡æ°Žã
ãã©ããããã©ã³10c.c.äžã«æº¶è§£ããïŒmlã®ïŒ®ïŒïŒ®
âãžâã¡ãã«ãšã¿ããŒã«ã¢ãã³ãæ·»å ããã宀枩
ã«ãããŠ18æéæ¹æåŸãæ··åç©ãèžçºä¹Ÿåºãã
ããæ®æž£ããšãŒãã«ãšçšå¡©é žã®éã§åé ãè¡ãæ°Ž
å±€ãåé¢ããããã®æ°Žå±€ãã¢ã³ã¢ãã¢æ°Žã§å¡©åºæ§
ã«ããŠé ¢é žãšãã«ã§æœåºãè¡ããææ©å±€ãçå»
ããæ®æž£ãã·ãªã«ã²ã«äžã§90ïŒ ã¯ãããã«ã ã¡ã¿
ããŒã«æº¶æ¶²ãçšããŠæº¶é¢ããã¯ãããã°ã©ãåæ
ãè¡ãç®ççæç©ãåŸãã
ïœ ããªãã»ãã³âïŒâã«ã«ãã³é žâβâãžã¡ã
ã«ã¢ãããšãã«ãšã¹ãã« å®æœäŸ10ã®å·¥çšïŒ¡ã§äœãããïŒâã¯ããã«ã«ã
ãã«âïŒïŒ11âãžãããâ11âãªããœâãžãã³ãº
ãïœïŒïœ ããªãã»ãã³1.0ïœãæ¹æããªããç¡æ°Žã
ãã©ããããã©ã³10c.c.äžã«æº¶è§£ããïŒmlã®ïŒ®ïŒïŒ®
âãžâã¡ãã«ãšã¿ããŒã«ã¢ãã³ãæ·»å ããã宀枩
ã«ãããŠ18æéæ¹æåŸãæ··åç©ãèžçºä¹Ÿåºãã
ããæ®æž£ããšãŒãã«ãšçšå¡©é žã®éã§åé ãè¡ãæ°Ž
å±€ãåé¢ããããã®æ°Žå±€ãã¢ã³ã¢ãã¢æ°Žã§å¡©åºæ§
ã«ããŠé ¢é žãšãã«ã§æœåºãè¡ããææ©å±€ãçå»
ããæ®æž£ãã·ãªã«ã²ã«äžã§90ïŒ ã¯ãããã«ã ã¡ã¿
ããŒã«æº¶æ¶²ãçšããŠæº¶é¢ããã¯ãããã°ã©ãåæ
ãè¡ãç®ççæç©ãåŸãã
ïŒïŒ®âãžã¡ãã«ãšã¿ããŒã«ã¢ãã³ã®ä»£ãã«å¥
ã®ïŒ®ïŒïŒ®âãžäœçŽã¢ã«ãã«ã¢ããäœçŽã¢ã«ã«ããŒ
ã«äŸãã°ããžã¡ãã«ãšã¿ããŒã«ã¢ãã³ããžãšãã«
ãšã¿ããŒã«ã¢ãã³ãïŒâïŒïŒ®âãžã¡ãã«ã¢ãã
ãããã³âïŒâãªãŒã«ãïŒâïŒïŒ®âãžãšãã«ã¢
ãããã¿ã³âïŒâãªãŒã«ãªã©ãçšããä»ã¯åæ§ã«
ããŠå¯Ÿå¿ããïŒïŒ®âãžäœçŽã¢ã«ãã«ã¢ããäœçŽ
ã¢ã«ãã«ãšã¹ãã«ãåŸããããåãäžèšã§çšãã
ïŒâã¯ããã«ã«ããã«âïŒïŒ11âãžãããâ11â
ãªããœãžãã³ãºãïœïŒïœ ããªãã»ãã³ã®ä»£ãã«ïŒ
âã¯ããã«ã«ããã«ïŒïŒ11âãžãããâ11âãªã
ãœãžãã³ãºãïœïŒïœ ããªãã»ãã³ãçšããããšã«
ããïŒïŒ®âãžäœçŽã¢ã«ãã«ïŒâã«ã«ããã·ã¬ãŒ
ããšã¹ãã«ãåŸãããã
ã®ïŒ®ïŒïŒ®âãžäœçŽã¢ã«ãã«ã¢ããäœçŽã¢ã«ã«ããŒ
ã«äŸãã°ããžã¡ãã«ãšã¿ããŒã«ã¢ãã³ããžãšãã«
ãšã¿ããŒã«ã¢ãã³ãïŒâïŒïŒ®âãžã¡ãã«ã¢ãã
ãããã³âïŒâãªãŒã«ãïŒâïŒïŒ®âãžãšãã«ã¢
ãããã¿ã³âïŒâãªãŒã«ãªã©ãçšããä»ã¯åæ§ã«
ããŠå¯Ÿå¿ããïŒïŒ®âãžäœçŽã¢ã«ãã«ã¢ããäœçŽ
ã¢ã«ãã«ãšã¹ãã«ãåŸããããåãäžèšã§çšãã
ïŒâã¯ããã«ã«ããã«âïŒïŒ11âãžãããâ11â
ãªããœãžãã³ãºãïœïŒïœ ããªãã»ãã³ã®ä»£ãã«ïŒ
âã¯ããã«ã«ããã«ïŒïŒ11âãžãããâ11âãªã
ãœãžãã³ãºãïœïŒïœ ããªãã»ãã³ãçšããããšã«
ããïŒïŒ®âãžäœçŽã¢ã«ãã«ïŒâã«ã«ããã·ã¬ãŒ
ããšã¹ãã«ãåŸãããã
å®æœäŸ 18
âã«ã«ããã·äœçŽã¢ã«ãã«ïŒïŒ11âãžããã
â11âãªããœãžãã³ãºãïœïŒïœ ããªãã»ãã³â
ïŒâã«ã«ãããµãã 1.0ïœã®ïŒâã¯ããã«ã«ããã«âïŒïŒ11âãžã
ããâ11âãªããœãžãã³ãºãïœïŒïœ ããªãã»ãã³
ã2.0ïœã®ã°ãªã·ã³ãå«æãã20c.c.ã®é ¢é žãšãã«
äžã§ïŒæééæµããããæ··åç©ãèžçºä¹ŸåºãããŠ
åºäœæ®æž£ã«30c.c.ã®æ°Žãæ·»å ãã宀枩ã§ïŒæéæ¹æ
ãè¡ããåºäœãå¥ãããšã¿ããŒã«ããçµæ¶åã
ããŠç®ççæç©ãåŸãã
â11âãªããœãžãã³ãºãïœïŒïœ ããªãã»ãã³â
ïŒâã«ã«ãããµãã 1.0ïœã®ïŒâã¯ããã«ã«ããã«âïŒïŒ11âãžã
ããâ11âãªããœãžãã³ãºãïœïŒïœ ããªãã»ãã³
ã2.0ïœã®ã°ãªã·ã³ãå«æãã20c.c.ã®é ¢é žãšãã«
äžã§ïŒæééæµããããæ··åç©ãèžçºä¹ŸåºãããŠ
åºäœæ®æž£ã«30c.c.ã®æ°Žãæ·»å ãã宀枩ã§ïŒæéæ¹æ
ãè¡ããåºäœãå¥ãããšã¿ããŒã«ããçµæ¶åã
ããŠç®ççæç©ãåŸãã
ã°ãªã·ã³ã®ä»£ãã«ã¢ã©ãã³åã¯ããªã³ã®ãããª
å¥ã®ã¢ããé žãçšããä»ã¯åæ§ã«ããŠå¯Ÿå¿ããïŒ
âã«ã«ããã·ã«äœçŽã¢ã«ãã«ã«ã«ãããµãããåŸ
ãããã
å¥ã®ã¢ããé žãçšããä»ã¯åæ§ã«ããŠå¯Ÿå¿ããïŒ
âã«ã«ããã·ã«äœçŽã¢ã«ãã«ã«ã«ãããµãããåŸ
ãããã
åãäžèšã§çšããïŒâã¯ããã«ã«ããã«âïŒïŒ
11âãžãããâ11âãªããœãžãã³ãºãïœïŒïœ ããª
ãã»ãã³ã®ä»£ãã«ïŒâã¯ããã«ã«ããã«âïŒïŒ11
âãžãããâ11âãªããœãžãã³ãºãïœïŒïœ ããªã
ã»ãã³ãçšããããšã«ãã€ãŠå¯Ÿå¿ããïŒâã«ã«ã
ãã·äœçŽã¢ã«ãã«ã«ã«ãããµãããåŸãããã
11âãžãããâ11âãªããœãžãã³ãºãïœïŒïœ ããª
ãã»ãã³ã®ä»£ãã«ïŒâã¯ããã«ã«ããã«âïŒïŒ11
âãžãããâ11âãªããœãžãã³ãºãïœïŒïœ ããªã
ã»ãã³ãçšããããšã«ãã€ãŠå¯Ÿå¿ããïŒâã«ã«ã
ãã·äœçŽã¢ã«ãã«ã«ã«ãããµãããåŸãããã
å®æœäŸ 19
ïŒïŒ11âãžãããâ11âãªããœãžãã³ãºãïœïŒ
ïœ ããªãã»ãã³âïŒâã«ã«ãã³é žâβâã«ã«ã
ãã·ãšãã«ãšã¹ãã« 1.0ïœã®ïŒâã¯ããã«ã«ããã«âïŒïŒ11âãžã
ããâ11âãªããœãžãã³ãºãïœïŒïœ ããªãã»ãã³
ã20c.c.ã®ããã©ãã€ãããã©ã³ã«æº¶è§£ã1.0ïœã®
βâããããã·ããããªã³é žã®ãããªãŠã å¡©ãæ·»
å ãããæ··åç©ã宀枩ã§18æéæ¹æãããéã
è¡ãã液ãèžçºä¹Ÿåºãããåºäœæ®æž£ããšã¿ããŒ
ã«ããåçµæ¶ãããŠç®ççæç©ãåŸãã
ïœ ããªãã»ãã³âïŒâã«ã«ãã³é žâβâã«ã«ã
ãã·ãšãã«ãšã¹ãã« 1.0ïœã®ïŒâã¯ããã«ã«ããã«âïŒïŒ11âãžã
ããâ11âãªããœãžãã³ãºãïœïŒïœ ããªãã»ãã³
ã20c.c.ã®ããã©ãã€ãããã©ã³ã«æº¶è§£ã1.0ïœã®
βâããããã·ããããªã³é žã®ãããªãŠã å¡©ãæ·»
å ãããæ··åç©ã宀枩ã§18æéæ¹æãããéã
è¡ãã液ãèžçºä¹Ÿåºãããåºäœæ®æž£ããšã¿ããŒ
ã«ããåçµæ¶ãããŠç®ççæç©ãåŸãã
βâããããã·ããããªã³é
žãããªãŠã å¡©ã®ä»£
ãã«ãäŸãã°ãããããã·é ¢é žãïŒâããããã·
é ªé žãªã©ã®ã¢ã«ã«ãªéå±å¡©ã®ãããªå¥ã®ãããã
ã·äœçŽã¢ã«ã«ã³é žå¡©ãçšããä»ã¯åæ§ã«ããŠå¯Ÿå¿
ããã«ã«ããã·äœçŽã¢ã«ãã«âïŒâã«ã«ããã·ã¬
ãŒããšã¹ãã«ãåŸããããåãïŒâã¯ããã«ã«ã
ãã«âïŒïŒ11âãžãããâ11âãªããœãžãã³ãº
ãïœïŒïœ ããªãã»ãã³ã®ä»£ãã«ïŒâã¯ããã«ã«ã
ãã«âïŒïŒ11âãžãããâ11âãªããœãžãã³ãº
ãïœïŒïœ ããªãã»ãã³ãçšããããšã«ãã察å¿ã
ãã«ã«ããã·äœçŽã¢ã«ãã«âïŒâã«ã«ããã·ã¬ãŒ
ããšã¹ãã«ãåŸãããã
ãã«ãäŸãã°ãããããã·é ¢é žãïŒâããããã·
é ªé žãªã©ã®ã¢ã«ã«ãªéå±å¡©ã®ãããªå¥ã®ãããã
ã·äœçŽã¢ã«ã«ã³é žå¡©ãçšããä»ã¯åæ§ã«ããŠå¯Ÿå¿
ããã«ã«ããã·äœçŽã¢ã«ãã«âïŒâã«ã«ããã·ã¬
ãŒããšã¹ãã«ãåŸããããåãïŒâã¯ããã«ã«ã
ãã«âïŒïŒ11âãžãããâ11âãªããœãžãã³ãº
ãïœïŒïœ ããªãã»ãã³ã®ä»£ãã«ïŒâã¯ããã«ã«ã
ãã«âïŒïŒ11âãžãããâ11âãªããœãžãã³ãº
ãïœïŒïœ ããªãã»ãã³ãçšããããšã«ãã察å¿ã
ãã«ã«ããã·äœçŽã¢ã«ãã«âïŒâã«ã«ããã·ã¬ãŒ
ããšã¹ãã«ãåŸãããã
å®æœäŸ 20
ïŒâïŒ1Hâããã©ãŸãŒã«âïŒâã€ã«ïŒâïŒïŒ11
âãžãããâ11âããããã·ãžãã³ãºãïœïŒ
ïœ ããªãã»ãã³ ïŒïœã®ïŒâïŒ1Hâããã©ãŸãŒã«âïŒâã€ã«ïŒâ
ïŒïŒ11âãžãããâ11âãªããœãžãã³ãºãïœïŒ
ïœ ããªãã»ãã³ã100c.c.ã®ç¡æ°Žãšã¿ããŒã«äžã«æž
æ¿ãããéå°ã®ããŠæ°ŽçŽ åãããªãŠã ãåå²æ·»å
ãããåŸããã溶液ãæ°Žã§çšéãæ¿å¡©é žã§é žæ§å
ãããåºåœ¢åãå¥ããé ¢é žãšãã«ããåçµæ¶ã
ããŠç®ççæç©ãåŸãïŒèç¹335âïŒã
âãžãããâ11âããããã·ãžãã³ãºãïœïŒ
ïœ ããªãã»ãã³ ïŒïœã®ïŒâïŒ1Hâããã©ãŸãŒã«âïŒâã€ã«ïŒâ
ïŒïŒ11âãžãããâ11âãªããœãžãã³ãºãïœïŒ
ïœ ããªãã»ãã³ã100c.c.ã®ç¡æ°Žãšã¿ããŒã«äžã«æž
æ¿ãããéå°ã®ããŠæ°ŽçŽ åãããªãŠã ãåå²æ·»å
ãããåŸããã溶液ãæ°Žã§çšéãæ¿å¡©é žã§é žæ§å
ãããåºåœ¢åãå¥ããé ¢é žãšãã«ããåçµæ¶ã
ããŠç®ççæç©ãåŸãïŒèç¹335âïŒã
å®æœäŸ 21
ïŒïŒ11âãžãããâ11âãªããœãžãã³ãºãïœïŒ
ïœ ããªãã»ãã³âïŒâã«ã«ãã³é žã¡ãã«ãšã¹ã
ã« ïŒïŒ11âãžãããâ11âãªããœãžãã³ãºãïœïŒ
ïœ ããªãã»ãã³âïŒâã«ã«ãã³é žïŒïœãïŒc.c.ã®ç¡«
é žãå«æããã¡ã¿ããŒã«600c.c.äžã§19æééæµã
ãããå·åŽåŸåºåœ¢åãå¥ããŠç®ççæç©ãåŸã
ïŒèç¹130ã131âïŒã
ïœ ããªãã»ãã³âïŒâã«ã«ãã³é žã¡ãã«ãšã¹ã
ã« ïŒïŒ11âãžãããâ11âãªããœãžãã³ãºãïœïŒ
ïœ ããªãã»ãã³âïŒâã«ã«ãã³é žïŒïœãïŒc.c.ã®ç¡«
é žãå«æããã¡ã¿ããŒã«600c.c.äžã§19æééæµã
ãããå·åŽåŸåºåœ¢åãå¥ããŠç®ççæç©ãåŸã
ïŒèç¹130ã131âïŒã
æŽã«è¿œå ç£ç©ãåŸãããã«éå°ã®éçé
žãããª
ãŠã ã液ã«å ããŠèžçºä¹ŸåºããŠã¯ãããã«ã ã§
æœåºããã
ãŠã ã液ã«å ããŠèžçºä¹ŸåºããŠã¯ãããã«ã ã§
æœåºããã
å®æœäŸ 22
ïŒïŒ11âãžãããâ11âããããã·ãžãã³ãº
ãïœïŒïœ ããªãã»ãã³âïŒâã«ã«ãã³é ž å·¥çšïŒ¡ïŒïŒïŒ11âãžãããâ11âããããã·ãžã
ã³ãºãïœïŒïœ ããªãã»ãã³âïŒâã«ã«ãã³é žã¡
ãã«ãšã¹ãã« ïŒïŒ11âãžãããâ11âãªããœãžãã³ãºãïœïŒ
ïœ ããªãã»ãã³âïŒâã«ã«ãã³é žã¡ãã«ãšã¹ãã«
4.4ïœãå æž©ããªãã500c.c.ã®ã¡ã¿ããŒã«äžã«æº¶è§£
ããããéå°ã®ããŠæ°ŽçŽ åãããªãŠã ãåå²æ·»å
ãããæ··åç©ãèžçºä¹ŸåºãããŠæ®æž£ãæ°Žåã³ã¯ã
ããã«ã éã«åé ãããææ©çžãåé¢ãèžçºãè¡
ã€ãŠç®ççæç©ãåŸãã
ãïœïŒïœ ããªãã»ãã³âïŒâã«ã«ãã³é ž å·¥çšïŒ¡ïŒïŒïŒ11âãžãããâ11âããããã·ãžã
ã³ãºãïœïŒïœ ããªãã»ãã³âïŒâã«ã«ãã³é žã¡
ãã«ãšã¹ãã« ïŒïŒ11âãžãããâ11âãªããœãžãã³ãºãïœïŒ
ïœ ããªãã»ãã³âïŒâã«ã«ãã³é žã¡ãã«ãšã¹ãã«
4.4ïœãå æž©ããªãã500c.c.ã®ã¡ã¿ããŒã«äžã«æº¶è§£
ããããéå°ã®ããŠæ°ŽçŽ åãããªãŠã ãåå²æ·»å
ãããæ··åç©ãèžçºä¹ŸåºãããŠæ®æž£ãæ°Žåã³ã¯ã
ããã«ã éã«åé ãããææ©çžãåé¢ãèžçºãè¡
ã€ãŠç®ççæç©ãåŸãã
å·¥çšïŒ¢ïŒïŒïŒ11âãžãããâ11âããããã·ãžã
ã³ãºãïœïŒïœ ããªãã»ãã³âïŒâã«ã«ãã³é ž ïŒïŒ11âãžãããâ11âããããã·ãžãã³ãº
ãïœïŒïœ ããªãã»ãã³âïŒâã«ã«ãã³é žã¡ãã«ãš
ã¹ãã«900mgã20c.c.ã®ããã©ããããã©ã³ã«æº¶è§£
ããã20c.c.ã®1Næ°Žé žåãããªãŠã 氎溶液ãæ·»å
ããã宀枩ã§48æéæ¹æãããæ°Žã§çšéåŸãšãŒã
ã«ã§æœåºãè¡ããæ°Žæ§éšåãå¡©é žã§é žæ§åããšãŒ
ãã«ã§æœåºãè¡ããææ©çžãèžçºãããŠç®ççæ
ç©ãåŸãïŒèç¹275âãå解ïŒã
ã³ãºãïœïŒïœ ããªãã»ãã³âïŒâã«ã«ãã³é ž ïŒïŒ11âãžãããâ11âããããã·ãžãã³ãº
ãïœïŒïœ ããªãã»ãã³âïŒâã«ã«ãã³é žã¡ãã«ãš
ã¹ãã«900mgã20c.c.ã®ããã©ããããã©ã³ã«æº¶è§£
ããã20c.c.ã®1Næ°Žé žåãããªãŠã 氎溶液ãæ·»å
ããã宀枩ã§48æéæ¹æãããæ°Žã§çšéåŸãšãŒã
ã«ã§æœåºãè¡ããæ°Žæ§éšåãå¡©é žã§é žæ§åããšãŒ
ãã«ã§æœåºãè¡ããææ©çžãèžçºãããŠç®ççæ
ç©ãåŸãïŒèç¹275âãå解ïŒã
å®æœäŸ 23
ïŒïŒ11âãžãããâ11âã¯ãããžãã³ãºãïœïŒ
ïœ ããªãã»ãã³âïŒâã«ã«ãã³é žã¡ãã«ãšã¹ã
ã« ïŒïŒ11âãžãããâ11âããããã·ãžãã³ãº
ãïœïŒïœ ããªãã»ãã³âïŒâã«ã«ãã³é žã¡ãã«ãš
ã¹ãã«3.14ïœåã³å¡©åããªãã«15c.c.ã10åééæµ
ããããéå°å¡©åããªãã«ãèžçºããããå¡©åã
ãªãã«ã®åŸ®éåããã³ãŒã³ãšå ±èžçãããŠé€å»ã
ãããšã«ããç®ççæç©ãåŸãïŒåé3.35ïœã
100ïŒ ïŒã
ïœ ããªãã»ãã³âïŒâã«ã«ãã³é žã¡ãã«ãšã¹ã
ã« ïŒïŒ11âãžãããâ11âããããã·ãžãã³ãº
ãïœïŒïœ ããªãã»ãã³âïŒâã«ã«ãã³é žã¡ãã«ãš
ã¹ãã«3.14ïœåã³å¡©åããªãã«15c.c.ã10åééæµ
ããããéå°å¡©åããªãã«ãèžçºããããå¡©åã
ãªãã«ã®åŸ®éåããã³ãŒã³ãšå ±èžçãããŠé€å»ã
ãããšã«ããç®ççæç©ãåŸãïŒåé3.35ïœã
100ïŒ ïŒã
å®æœäŸ 24
ïŒïŒ11âãžãããâ11âã¡ãã«ã¹ã«ããã«ãžã
ã³ãºãïœïŒïœ ããªãã»ãã³âïŒâã«ã«ãã³é ž å·¥çšïŒ¡ïŒïŒïŒ11âãžãããâ11âã¡ãã«ã¹ã«ãã
ã«ãžãã³ãºãïœïŒïœ ããªãã»ãã³âïŒâã«ã«ã
ã³é žã¡ãã«ãšã¹ãã« ïŒïŒ11âãžãããâ11âããããã·ãžãã³ãº
ãïœïŒïœ ããªãã»ãã³âïŒâã«ã«ãã³é žã¡ãã«ãš
ã¹ãã«1.4ïœãïŒc.c.ã®å¡©åããªãã«äžã§10åéé
æµããããéå°ã®å¡©åããªãã«ãçå»ãåŸããã
ã¯ããäžéäœã14c.c.ã®ïŒ®ïŒïŒ®âãžã¡ãã«ãã«ã ã¢
ããäžã«æº¶è§£ããã582ïœã®ã¡ã¿ã³ã¹ã«ãã€ã³é ž
ãããªãŠã å¡©ïŒ10ïŒ éå°ïŒãæ·»å ããã宀枩ã«ã
ããŠïŒæ¥éæ¹æãããæ°Žã§çšéåŸãåºåœ¢åãå¥
ããã15c.c.ã®ãã³ãŒã³ããçµæ¶åãããŠç®ççæ
ç©ãåŸãïŒåé1.18ïœã68.6ïŒ ïŒã
ã³ãºãïœïŒïœ ããªãã»ãã³âïŒâã«ã«ãã³é ž å·¥çšïŒ¡ïŒïŒïŒ11âãžãããâ11âã¡ãã«ã¹ã«ãã
ã«ãžãã³ãºãïœïŒïœ ããªãã»ãã³âïŒâã«ã«ã
ã³é žã¡ãã«ãšã¹ãã« ïŒïŒ11âãžãããâ11âããããã·ãžãã³ãº
ãïœïŒïœ ããªãã»ãã³âïŒâã«ã«ãã³é žã¡ãã«ãš
ã¹ãã«1.4ïœãïŒc.c.ã®å¡©åããªãã«äžã§10åéé
æµããããéå°ã®å¡©åããªãã«ãçå»ãåŸããã
ã¯ããäžéäœã14c.c.ã®ïŒ®ïŒïŒ®âãžã¡ãã«ãã«ã ã¢
ããäžã«æº¶è§£ããã582ïœã®ã¡ã¿ã³ã¹ã«ãã€ã³é ž
ãããªãŠã å¡©ïŒ10ïŒ éå°ïŒãæ·»å ããã宀枩ã«ã
ããŠïŒæ¥éæ¹æãããæ°Žã§çšéåŸãåºåœ¢åãå¥
ããã15c.c.ã®ãã³ãŒã³ããçµæ¶åãããŠç®ççæ
ç©ãåŸãïŒåé1.18ïœã68.6ïŒ ïŒã
å·¥çšïŒ¢ïŒïŒïŒ11âãžãããâ11âã¡ãã«ã¹ã«ãã
ã«ãžãã³ãºãïœïŒïœ ããªãã»ãã³âïŒâã«ã«ã
ã³é ž å·¥çšïŒ¡ã®ãšã¹ãã«ïŒïœåã³40c.c.ã®1Næ°Žé žåã
ããªãŠã 溶液ã15åééæµããããèžçºä¹Ÿåºãã
ãŠæ®æž£ãæ°Žã«æº¶è§£ããããæ°Žæ§å¡©é žã§é žæ§ã«ãã
åºåœ¢åãå¥ããŠç®ççæç©ãåŸãïŒèç¹251âã
å解ïŒã
ã«ãžãã³ãºãïœïŒïœ ããªãã»ãã³âïŒâã«ã«ã
ã³é ž å·¥çšïŒ¡ã®ãšã¹ãã«ïŒïœåã³40c.c.ã®1Næ°Žé žåã
ããªãŠã 溶液ã15åééæµããããèžçºä¹Ÿåºãã
ãŠæ®æž£ãæ°Žã«æº¶è§£ããããæ°Žæ§å¡©é žã§é žæ§ã«ãã
åºåœ¢åãå¥ããŠç®ççæç©ãåŸãïŒèç¹251âã
å解ïŒã
å®æœäŸ 25
ïŒïŒ11âãžãããâ11âã¡ãã«ããªãžãã³ãº
ãïœïŒïœ ããªãã»ãã³âïŒâã«ã«ãã³é ž å·¥çšïŒ¡ïŒïŒïŒ11âãžãããâ11âã¡ãã«ããªãžã
ã³ãºãïœïŒïœ ããªãã»ãã³âïŒâã«ã«ãã³é žã¡
ãã«ãšã¹ãã« ã¡ã¿ã³ããªãŒã«ã40mlã®ä¹Ÿç¥ãžã¡ãã«ãã«ã ã¢
ãããéããŠçŽ10åé溶液ã飜åã«ãªããŸã§å¹èŸŒ
ãã8.6ïœã®ïŒïŒ11âãžãããâ11âã¯ãããžã
ã³ãºãïœïŒïœ ããªãã»ãã³âïŒâã«ã«ãã³é žã¡ã
ã«ãšã¹ãã«ãæ·»å ããã¡ã¿ã³ããªãŒã«ãåŒç¶ãå¹
蟌ã¿ãªãã宀枩ã§20åéæ¹æãããã¡ã¿ã³ããªãŒ
ã«ã®æ·»å ãåæ¢ããŠæ¹æã宀枩ã§ïŒæéç¶ããã
åå¿æ¶²ã500c.c.ã®ãšãŒãã«ã§çšéãã100c.c.ã®ïŒïŒ
æ°Žé žåã«ãªãŠã 氎溶液ã§ïŒåæŽæµãããç¡æ°Žç¡«é ž
ãããªãŠã äžã§ä¹Ÿç¥ããæ¿çž®ä¹ŸåºããŠç®ççµæç©
åŸãïŒåé8.49ïœã95ïŒ ïŒã
ãïœïŒïœ ããªãã»ãã³âïŒâã«ã«ãã³é ž å·¥çšïŒ¡ïŒïŒïŒ11âãžãããâ11âã¡ãã«ããªãžã
ã³ãºãïœïŒïœ ããªãã»ãã³âïŒâã«ã«ãã³é žã¡
ãã«ãšã¹ãã« ã¡ã¿ã³ããªãŒã«ã40mlã®ä¹Ÿç¥ãžã¡ãã«ãã«ã ã¢
ãããéããŠçŽ10åé溶液ã飜åã«ãªããŸã§å¹èŸŒ
ãã8.6ïœã®ïŒïŒ11âãžãããâ11âã¯ãããžã
ã³ãºãïœïŒïœ ããªãã»ãã³âïŒâã«ã«ãã³é žã¡ã
ã«ãšã¹ãã«ãæ·»å ããã¡ã¿ã³ããªãŒã«ãåŒç¶ãå¹
蟌ã¿ãªãã宀枩ã§20åéæ¹æãããã¡ã¿ã³ããªãŒ
ã«ã®æ·»å ãåæ¢ããŠæ¹æã宀枩ã§ïŒæéç¶ããã
åå¿æ¶²ã500c.c.ã®ãšãŒãã«ã§çšéãã100c.c.ã®ïŒïŒ
æ°Žé žåã«ãªãŠã 氎溶液ã§ïŒåæŽæµãããç¡æ°Žç¡«é ž
ãããªãŠã äžã§ä¹Ÿç¥ããæ¿çž®ä¹ŸåºããŠç®ççµæç©
åŸãïŒåé8.49ïœã95ïŒ ïŒã
å·¥çšïŒ¢ïŒïŒïŒ11âãžãããâ11âã¡ãã«ããªãžã
ã³ãºãïœïŒïœ ããªãã»ãã³âïŒâã«ã«ãã³é ž å·¥çšïŒ¡ã®ã¹ã«ãã€ããšã¹ãã«4.0ïœãã¡ã¿ããŒ
ã«25mlãããã©ããããã©ã³25mlåã³40ïŒ æ°Žé žå
ãããªãŠã 氎溶液50mlã®æ··åç©ã«æžæ¿ããçªçŽ é°
å²æ°äžã«20åééæµãããã宀枩ãŸã§å·åŽããæ°·
äžã«æ³šå ãããæ¿å¡©é žã§é žæ§ã«ããŠ300mlã®å¡©å
ã¡ãã¬ã³ã§ïŒåæœåºãè¡ããæœåºæ¶²ãåãããŠé£œ
åå¡©åãããªãŠã 氎溶液ã§æŽæµããç¡æ°Žç¡«é žãã
ãªãŠã äžã§ä¹Ÿç¥ãèžçºä¹ŸåºããŠç®ççæç©ãåŸã
ïŒèç¹198ã200âïŒã
ã³ãºãïœïŒïœ ããªãã»ãã³âïŒâã«ã«ãã³é ž å·¥çšïŒ¡ã®ã¹ã«ãã€ããšã¹ãã«4.0ïœãã¡ã¿ããŒ
ã«25mlãããã©ããããã©ã³25mlåã³40ïŒ æ°Žé žå
ãããªãŠã 氎溶液50mlã®æ··åç©ã«æžæ¿ããçªçŽ é°
å²æ°äžã«20åééæµãããã宀枩ãŸã§å·åŽããæ°·
äžã«æ³šå ãããæ¿å¡©é žã§é žæ§ã«ããŠ300mlã®å¡©å
ã¡ãã¬ã³ã§ïŒåæœåºãè¡ããæœåºæ¶²ãåãããŠé£œ
åå¡©åãããªãŠã 氎溶液ã§æŽæµããç¡æ°Žç¡«é žãã
ãªãŠã äžã§ä¹Ÿç¥ãèžçºä¹ŸåºããŠç®ççæç©ãåŸã
ïŒèç¹198ã200âïŒã
å·¥çšïŒ¡ã®ã¡ã¿ã³ããªãŒã«ã®ä»£ãã«ãäŸãã°ãšã¿
ã³ããªãŒã«ããããã«ããªãŒã«ãã€ãœãããã«ã
ãªãŒã«ãïœâããã«ããªãŒã«ãªã©ã®ä»ã®äœçŽã¢ã«
ãã«ããªãŒã«ãçšããããšã«ãã€ãŠå¯Ÿå¿ãã11â
äœçŽã¢ã«ãã«ããªååç©ãåŸããããåãäžèšã«
ãããŠçšããããïŒïŒ11âãžãããâ11âã¯ãã
ãžãã³ãºãïœïŒïœ ããªãã»ãã³âïŒâã«ã«ãã³é ž
ã¡ãã«ãšã¹ãã«ã®ä»£ãã«ïŒâã¡ãã«ã«ã«ãã³é žãš
ã¹ãã«ãçšããããšã«ãã察å¿ããïŒâã«ã«ãã³
é žãåŸãããã
ã³ããªãŒã«ããããã«ããªãŒã«ãã€ãœãããã«ã
ãªãŒã«ãïœâããã«ããªãŒã«ãªã©ã®ä»ã®äœçŽã¢ã«
ãã«ããªãŒã«ãçšããããšã«ãã€ãŠå¯Ÿå¿ãã11â
äœçŽã¢ã«ãã«ããªååç©ãåŸããããåãäžèšã«
ãããŠçšããããïŒïŒ11âãžãããâ11âã¯ãã
ãžãã³ãºãïœïŒïœ ããªãã»ãã³âïŒâã«ã«ãã³é ž
ã¡ãã«ãšã¹ãã«ã®ä»£ãã«ïŒâã¡ãã«ã«ã«ãã³é žãš
ã¹ãã«ãçšããããšã«ãã察å¿ããïŒâã«ã«ãã³
é žãåŸãããã
å®æœäŸ 26
ïŒïŒ11âãžãããâ11âã¡ãã«ã¹ã«ãã€ãã«ãž
ãã³ãºãïœïŒïœ ããªãã»ãã³âïŒâã«ã«ãã³é ž ïŒïŒ11âãžãããâ11âã¡ã¿ã«ããªãžãã³ãº
ãïœïŒïœ ããªãã»ãã³âïŒâã«ã«ãã³é ž380mgãæž©
ããªãã38mlã®æ°·é ¢é žäžã«æº¶è§£ãããåå¿æ¶²ã40
âã®æ²¹æµŽå ã«å ¥ã30ïŒ éé žåæ°ŽçŽ ã1.5mlæ·»å ã
ããæ··åç©ã40âã«ãããŠïŒ 1/2æéã溶液ãé
æã«ãªããŸã§æ¹æããã300mlã®æ°Žã§çšéãæåº
ç©ãå¥ããŠç®ççæç©ãåŸãã
ãã³ãºãïœïŒïœ ããªãã»ãã³âïŒâã«ã«ãã³é ž ïŒïŒ11âãžãããâ11âã¡ã¿ã«ããªãžãã³ãº
ãïœïŒïœ ããªãã»ãã³âïŒâã«ã«ãã³é ž380mgãæž©
ããªãã38mlã®æ°·é ¢é žäžã«æº¶è§£ãããåå¿æ¶²ã40
âã®æ²¹æµŽå ã«å ¥ã30ïŒ éé žåæ°ŽçŽ ã1.5mlæ·»å ã
ããæ··åç©ã40âã«ãããŠïŒ 1/2æéã溶液ãé
æã«ãªããŸã§æ¹æããã300mlã®æ°Žã§çšéãæåº
ç©ãå¥ããŠç®ççæç©ãåŸãã
å®æœäŸ 27
ïŒïŒ11âãžããããžãã³ãºãïœïŒïœ
ããªãã»ã
ã³âïŒâã«ã«ãã³é ž å·¥çšïŒ¡ïŒïŒïŒ11âãžããããžãã³ãºãïœïŒïœ ããª
ãã»ãã³âïŒâã«ã«ãã³é žã¡ãã«ãšã¹ãã« 4.4ïœã®ïŒïŒ11âãžãããâ11âããããã·ãž
ãã³ãºãïœïŒïœ ããªãã»ãã³âïŒâã«ã«ãã³é žã¡
ãã«ãšã¹ãã«ã20mlã®å¡©åããªãã«ãšå ±ã«10åé
éæµããããéå°å¡©åããªãã«ãçå»ããæ®æž£ã
30mlã®ãžã¡ãã«ãã«ã ã¢ããã«æº¶è§£ããããã®æ··
åç©ãã«ãªãŠã tertâãããã·3.4ïœã®ã¡ã¿ã³ããª
ãŒã«ã§é£œåããããžã¡ãã«ãã«ã ã¢ãã75mlã®æº¶
液ã«æ·»å ããã宀枩ã§24æéæ¹æããæ°Žã§çšéã
ãŠãšãŒãã«ã§æœåºãè¡ããèžçºä¹ŸåºããŠã·ãªã«ã²
ã«äžã§ãã«ãšã³ã§æº¶é¢ããŠã¯ãããã°ã©ããè¡
ãã溶é¢æ¶²ãèžçºä¹ŸåºããŠæ²¹ç¶ã®ç®ççæç©ãåŸ
ãïŒåé3.03ïœã84ïŒ ïŒã
ã³âïŒâã«ã«ãã³é ž å·¥çšïŒ¡ïŒïŒïŒ11âãžããããžãã³ãºãïœïŒïœ ããª
ãã»ãã³âïŒâã«ã«ãã³é žã¡ãã«ãšã¹ãã« 4.4ïœã®ïŒïŒ11âãžãããâ11âããããã·ãž
ãã³ãºãïœïŒïœ ããªãã»ãã³âïŒâã«ã«ãã³é žã¡
ãã«ãšã¹ãã«ã20mlã®å¡©åããªãã«ãšå ±ã«10åé
éæµããããéå°å¡©åããªãã«ãçå»ããæ®æž£ã
30mlã®ãžã¡ãã«ãã«ã ã¢ããã«æº¶è§£ããããã®æ··
åç©ãã«ãªãŠã tertâãããã·3.4ïœã®ã¡ã¿ã³ããª
ãŒã«ã§é£œåããããžã¡ãã«ãã«ã ã¢ãã75mlã®æº¶
液ã«æ·»å ããã宀枩ã§24æéæ¹æããæ°Žã§çšéã
ãŠãšãŒãã«ã§æœåºãè¡ããèžçºä¹ŸåºããŠã·ãªã«ã²
ã«äžã§ãã«ãšã³ã§æº¶é¢ããŠã¯ãããã°ã©ããè¡
ãã溶é¢æ¶²ãèžçºä¹ŸåºããŠæ²¹ç¶ã®ç®ççæç©ãåŸ
ãïŒåé3.03ïœã84ïŒ ïŒã
å·¥çšïŒ¢ïŒïŒïŒ11âãžããããžãã³ãºãïœïŒïœ
ããª
ãã»ãã³âïŒâã«ã«ãã³é ž å·¥çšïŒ¡ã®ãšã¹ãã«1.4ïœã®15mlã®ãšã¿ããŒã«ã«
溶解ãã15mlã®20ïŒ æ°Žé žåãããªãŠã 氎溶液ãæ·»
å ãããã¹ããŒã 济äžã§å®å šãªæº¶æ¶²ãåŸããããŸ
ã§éãã«å æž©ãããèžçºä¹ŸåºåŸã«æ°Žã«æº¶è§£ãã
ããæ¿å¡©é žã§é žæ§ã«ããŠæåºç©ãå¥ãããã¡ã¿
ããŒã«ããçµæ¶ãããŠç®ççæç©ãåŸãïŒèç¹
240ã244âïŒã
ãã»ãã³âïŒâã«ã«ãã³é ž å·¥çšïŒ¡ã®ãšã¹ãã«1.4ïœã®15mlã®ãšã¿ããŒã«ã«
溶解ãã15mlã®20ïŒ æ°Žé žåãããªãŠã 氎溶液ãæ·»
å ãããã¹ããŒã 济äžã§å®å šãªæº¶æ¶²ãåŸããããŸ
ã§éãã«å æž©ãããèžçºä¹ŸåºåŸã«æ°Žã«æº¶è§£ãã
ããæ¿å¡©é žã§é žæ§ã«ããŠæåºç©ãå¥ãããã¡ã¿
ããŒã«ããçµæ¶ãããŠç®ççæç©ãåŸãïŒèç¹
240ã244âïŒã
å®æœäŸ 28
ïŒïŒ11âãžãããâ11âã¡ããã·ãžãã³ãº
ãïœïŒïœ ããªãã»ãã³âïŒâã«ã«ãã³é ž å·¥çšïŒ¡ïŒïŒïŒ11âãžãããâ11âã¡ããã·ãžãã³
ãºãïœïŒïœ ããªãã»ãã³âïŒâã«ã«ãã³é žã¡ã
ã«ãšã¹ãã« 0.415ïœã®ã«ãªãŠã tertâãããã·ãïŒmlã®ã¡ã¿
ããŒã«åã³ïŒmlã®ãžã¡ãã«ãã«ã ã¢ãããæ··å
ããæ··åç©ãïŒïŒ11âãžãããâ11âã¯ãããã³
ãºãïœïŒïœ ããªãã»ãã³âïŒâã«ã«ãã³é žã¡ãã«
ãšã¹ãã«1.07ïœã®ãžã¡ãã«ãã«ã ã¢ãã40mlã®æº¶
液ã«æ·»å ããã宀枩ã§ïŒæ¥éæ¹æãè¡ããæ°Žã§çš
éåŸãšãŒãã«ã§æœåºãè¡ããèžçºä¹ŸåºããŠã·ãªã«
ã²ã«äžã§ãã³ãŒã³ã溶é¢æº¶åªãšããŠçšããŠã¯ãã
ãã°ã©ããè¡ãç®ççæç©ãåŸãã
ãïœïŒïœ ããªãã»ãã³âïŒâã«ã«ãã³é ž å·¥çšïŒ¡ïŒïŒïŒ11âãžãããâ11âã¡ããã·ãžãã³
ãºãïœïŒïœ ããªãã»ãã³âïŒâã«ã«ãã³é žã¡ã
ã«ãšã¹ãã« 0.415ïœã®ã«ãªãŠã tertâãããã·ãïŒmlã®ã¡ã¿
ããŒã«åã³ïŒmlã®ãžã¡ãã«ãã«ã ã¢ãããæ··å
ããæ··åç©ãïŒïŒ11âãžãããâ11âã¯ãããã³
ãºãïœïŒïœ ããªãã»ãã³âïŒâã«ã«ãã³é žã¡ãã«
ãšã¹ãã«1.07ïœã®ãžã¡ãã«ãã«ã ã¢ãã40mlã®æº¶
液ã«æ·»å ããã宀枩ã§ïŒæ¥éæ¹æãè¡ããæ°Žã§çš
éåŸãšãŒãã«ã§æœåºãè¡ããèžçºä¹ŸåºããŠã·ãªã«
ã²ã«äžã§ãã³ãŒã³ã溶é¢æº¶åªãšããŠçšããŠã¯ãã
ãã°ã©ããè¡ãç®ççæç©ãåŸãã
å·¥çšïŒ¢ïŒïŒïŒ11âãžãããâ11âã¡ããã·ãžãã³
ãºãïœïŒïœ ããªãã»ãã³âïŒâã«ã«ãã³é ž å·¥çšïŒ¡ã®ãšã¹ãã«695mgã15mlã®ã¡ã¿ããŒã«ã«
溶解ããã20ïŒ ã®æ°Žé žåãããªãŠã 氎溶液10mlã
æ·»å ããŠ100åééæµãããã200mlã®æ°Žã§çšéã
ãŠãšãŒãã«ã§æœåºãè¡ããæ°Žæ§éšåãæ¿å¡©é žã§é ž
æ§ã«ããŠãšãŒãã«äžã«æœåºãè¡ããèžçºä¹ŸåºããŠ
ã¡ã¿ããŒã«ããçµæ¶åãããŠç®ççæç©ãåŸã
ïŒèç¹185âå解ïŒã
ãºãïœïŒïœ ããªãã»ãã³âïŒâã«ã«ãã³é ž å·¥çšïŒ¡ã®ãšã¹ãã«695mgã15mlã®ã¡ã¿ããŒã«ã«
溶解ããã20ïŒ ã®æ°Žé žåãããªãŠã 氎溶液10mlã
æ·»å ããŠ100åééæµãããã200mlã®æ°Žã§çšéã
ãŠãšãŒãã«ã§æœåºãè¡ããæ°Žæ§éšåãæ¿å¡©é žã§é ž
æ§ã«ããŠãšãŒãã«äžã«æœåºãè¡ããèžçºä¹ŸåºããŠ
ã¡ã¿ããŒã«ããçµæ¶åãããŠç®ççæç©ãåŸã
ïŒèç¹185âå解ïŒã
å®æœäŸ 29
ïŒïŒ11âãžãããâ11âããšãã«ããªãžãã³ãº
ãïœïŒïœ ããªãã»ãã³âïŒâã«ã«ãã³é ž å·¥çšïŒ¡ïŒïŒïŒ11âãžãããâ11âããšãã«ããªãž
ãã³ãºãïœïŒïœ ããªãã»ãã³âïŒâã«ã«ãã³é ž
ã¡ãã«ãšã¹ãã« 0.5ïœã®çé žã«ãªãŠã ãïŒmlã®ãžã¡ãã«ãã«ã
ã¢ããã«æžæ¿ãããŠãªã70âã®æžæ¿æ¶²ã«0.12mlã®
ãã³ãŒã³ããªãŒã«ãæ·»å ãããçªçŽ é°å²æ°äžã«10
åéæ¹æãè¡ãã0.27ïœã®ïŒïŒ11âãžãããâ11
âã¯ãããžãã³ãºãïœïŒïœ ããªãã»ãã³âïŒâã«
ã«ãã³é žã¡ãã«ãšã¹ãã«ãæ·»å ããŠ15åéæ¹æã
è¡ããæ°Žã§çšéåŸãšãŒãã«ã§æœåºãè¡ããæœåºæ¶²
ãïŒïŒ æ°Žé žåã«ãªãŠã 氎溶液ã§æŽæµããæŽã«é£œå
å¡©åãããªãŠã 氎溶液ã§æŽæµãããç¡æ°Žç¡«é žãã
ãªãŠã äžã§ä¹Ÿç¥åŸãæ¿çž®ä¹ŸåºããŠç®ççæç©ãåŸ
ãïŒåé0.226ïœïŒã
ãïœïŒïœ ããªãã»ãã³âïŒâã«ã«ãã³é ž å·¥çšïŒ¡ïŒïŒïŒ11âãžãããâ11âããšãã«ããªãž
ãã³ãºãïœïŒïœ ããªãã»ãã³âïŒâã«ã«ãã³é ž
ã¡ãã«ãšã¹ãã« 0.5ïœã®çé žã«ãªãŠã ãïŒmlã®ãžã¡ãã«ãã«ã
ã¢ããã«æžæ¿ãããŠãªã70âã®æžæ¿æ¶²ã«0.12mlã®
ãã³ãŒã³ããªãŒã«ãæ·»å ãããçªçŽ é°å²æ°äžã«10
åéæ¹æãè¡ãã0.27ïœã®ïŒïŒ11âãžãããâ11
âã¯ãããžãã³ãºãïœïŒïœ ããªãã»ãã³âïŒâã«
ã«ãã³é žã¡ãã«ãšã¹ãã«ãæ·»å ããŠ15åéæ¹æã
è¡ããæ°Žã§çšéåŸãšãŒãã«ã§æœåºãè¡ããæœåºæ¶²
ãïŒïŒ æ°Žé žåã«ãªãŠã 氎溶液ã§æŽæµããæŽã«é£œå
å¡©åãããªãŠã 氎溶液ã§æŽæµãããç¡æ°Žç¡«é žãã
ãªãŠã äžã§ä¹Ÿç¥åŸãæ¿çž®ä¹ŸåºããŠç®ççæç©ãåŸ
ãïŒåé0.226ïœïŒã
å·¥çšïŒ¢ïŒïŒïŒ11âãžãããâ11âããšãã«ããªãž
ãã³ãºãïœïŒïœ ããªãã»ãã³âïŒâã«ã«ãã³é ž å·¥çšïŒ¡ã®ãšã¹ãã«650mgã15mlã®ã¡ã¿ããŒã«ã«
溶解ããã20ïŒ æ°Žé žåãããªãŠã 氎溶液10mlãæ·»
å ããŠ10åééæµãããã200mlã®æ°Žã§çšéããŠ
ãšãŒãã«ã§æœåºãè¡ããæ°Žæ§æœåºæ¶²ãæ¿å¡©é žã§é ž
æ§ã«ããŠãšãŒãã«äžã«æœåºãè¡ããèžçºä¹ŸåºããŠ
ã¡ã¿ããŒã«ããçµæ¶åãããŠç®ççæç©ãåŸãã
ãã³ãºãïœïŒïœ ããªãã»ãã³âïŒâã«ã«ãã³é ž å·¥çšïŒ¡ã®ãšã¹ãã«650mgã15mlã®ã¡ã¿ããŒã«ã«
溶解ããã20ïŒ æ°Žé žåãããªãŠã 氎溶液10mlãæ·»
å ããŠ10åééæµãããã200mlã®æ°Žã§çšéããŠ
ãšãŒãã«ã§æœåºãè¡ããæ°Žæ§æœåºæ¶²ãæ¿å¡©é žã§é ž
æ§ã«ããŠãšãŒãã«äžã«æœåºãè¡ããèžçºä¹ŸåºããŠ
ã¡ã¿ããŒã«ããçµæ¶åãããŠç®ççæç©ãåŸãã
å®æœäŸ 30
ïŒïŒ11âãžãããâ11âïŒïŒâã€ãããŸãªã«ïŒ
ãžãã³ãºãïœïŒïœ ããªãã»ãã³âïŒâã«ã«ãã³
é ž å·¥çšïŒ¡ïŒïŒïŒ11âãžãããâ11âïŒïŒâã€ãããŸ
ãªã«ïŒãžãã³ãºãïœïŒïœ ããªãã»ãã³âïŒâã«
ã«ãã³é žã¡ãã«ãšã¹ãã« ïŒïŒ11âãžãããâ11âã¯ãããžãã³ãºãïœïŒ
ïœ ããªãã»ãã³âïŒâã«ã«ãã³é žã¡ãã«ãšã¹ãã«
4.0ïœãã€ãããŸãŒã«2.0ïœã®ãžã¡ãã«ãã«ã ã¢ã
ã15mlã®78âã®æº¶æ¶²ã«æ·»å ãããçªçŽ é°å²æ°äžã«
ïŒæéæ¹æãè¡ãã宀枩ãŸã§å·åŽããŠ15mlã®æ°Žã«
泚å ããã125mlã®ãšãŒãã«ã§ïŒåæœåºãè¡ãã
ãšãŒãã«æœåºæ¶²ãåãããŠ50mlã®æ°Žã§ïŒååã³25
mlã®é£œåå¡©åãããªãŠã 溶液ã§æŽæµãããç¡æ°Žç¡«
é žãããªãŠã äžã§ä¹Ÿç¥ãè¡ããèžçºä¹ŸåºããŠç®ç
çæç©ãåŸãïŒåé3.12ïœïŒã
ãžãã³ãºãïœïŒïœ ããªãã»ãã³âïŒâã«ã«ãã³
é ž å·¥çšïŒ¡ïŒïŒïŒ11âãžãããâ11âïŒïŒâã€ãããŸ
ãªã«ïŒãžãã³ãºãïœïŒïœ ããªãã»ãã³âïŒâã«
ã«ãã³é žã¡ãã«ãšã¹ãã« ïŒïŒ11âãžãããâ11âã¯ãããžãã³ãºãïœïŒ
ïœ ããªãã»ãã³âïŒâã«ã«ãã³é žã¡ãã«ãšã¹ãã«
4.0ïœãã€ãããŸãŒã«2.0ïœã®ãžã¡ãã«ãã«ã ã¢ã
ã15mlã®78âã®æº¶æ¶²ã«æ·»å ãããçªçŽ é°å²æ°äžã«
ïŒæéæ¹æãè¡ãã宀枩ãŸã§å·åŽããŠ15mlã®æ°Žã«
泚å ããã125mlã®ãšãŒãã«ã§ïŒåæœåºãè¡ãã
ãšãŒãã«æœåºæ¶²ãåãããŠ50mlã®æ°Žã§ïŒååã³25
mlã®é£œåå¡©åãããªãŠã 溶液ã§æŽæµãããç¡æ°Žç¡«
é žãããªãŠã äžã§ä¹Ÿç¥ãè¡ããèžçºä¹ŸåºããŠç®ç
çæç©ãåŸãïŒåé3.12ïœïŒã
å·¥çšïŒ¢ïŒïŒïŒ11âãžãããâ11âïŒïŒâã€ãããŸ
ãªã«ïŒãžãã³ãºãïœïŒïœ ããªãã»ãã³âïŒâã«
ã«ãã³é ž å·¥çšïŒ¡ã®ãšã¹ãã«3.1ïœã60mlã®ã¡ã¿ããŒã«å
ã³60mlã®ããã©ããããã©ã³ã®æ··åç©äžã«æº¶è§£ã
ãã60mlã®ïŒïŒ æ°Žé žåã«ãªãŠã 氎溶液ãæ·»å ããŠ
æ··åç©ãçªçŽ é°å²æ°äžã«70âã«ãããŠïŒæéå ç±
ãããåå¿æ¶²ãæ°·äžã«æ³šããæ¿å¡©é žã§PHïŒã«é žæ§
åãããåºåœ¢åãå¥ããæ°ŽæŽããŠ60âã«ãããŠ
ç空äžã§ïŒæé也ç¥ããç®ççæç©ãåŸãïŒèç¹
244ã255âå解ïŒã
ãªã«ïŒãžãã³ãºãïœïŒïœ ããªãã»ãã³âïŒâã«
ã«ãã³é ž å·¥çšïŒ¡ã®ãšã¹ãã«3.1ïœã60mlã®ã¡ã¿ããŒã«å
ã³60mlã®ããã©ããããã©ã³ã®æ··åç©äžã«æº¶è§£ã
ãã60mlã®ïŒïŒ æ°Žé žåã«ãªãŠã 氎溶液ãæ·»å ããŠ
æ··åç©ãçªçŽ é°å²æ°äžã«70âã«ãããŠïŒæéå ç±
ãããåå¿æ¶²ãæ°·äžã«æ³šããæ¿å¡©é žã§PHïŒã«é žæ§
åãããåºåœ¢åãå¥ããæ°ŽæŽããŠ60âã«ãããŠ
ç空äžã§ïŒæé也ç¥ããç®ççæç©ãåŸãïŒèç¹
244ã255âå解ïŒã
å®æœäŸ 31
ïŒïŒ11âãžãããâ11âãã«ã ã¢ãããžãã³ãº
ãïœïŒïœ ããªãã»ãã³âïŒâã«ã«ãã³é žã¡ãã«
ãšã¹ãã« 2.35ïœã®ïŒïŒ11âãžãããâ11âã¯ãããžãã³
ãºãïœïŒïœ ããªãã»ãã³âïŒâã«ã«ãã³é žã¡ãã«
ãšã¹ãã«ã20mlã®ãã«ã ã¢ããã«æ·»å ãããæ··å
ç©ã110âã«ãããŠïŒæéå ç±æ¹æããã宀枩ã«
å·åŽããæ°Žã§çšéããŠåºåœ¢åãå¥åé¢ããŠç®ç
çæç©ãåŸãïŒåé2.18ïœã90ïŒ ïŒã
ãïœïŒïœ ããªãã»ãã³âïŒâã«ã«ãã³é žã¡ãã«
ãšã¹ãã« 2.35ïœã®ïŒïŒ11âãžãããâ11âã¯ãããžãã³
ãºãïœïŒïœ ããªãã»ãã³âïŒâã«ã«ãã³é žã¡ãã«
ãšã¹ãã«ã20mlã®ãã«ã ã¢ããã«æ·»å ãããæ··å
ç©ã110âã«ãããŠïŒæéå ç±æ¹æããã宀枩ã«
å·åŽããæ°Žã§çšéããŠåºåœ¢åãå¥åé¢ããŠç®ç
çæç©ãåŸãïŒåé2.18ïœã90ïŒ ïŒã
å®æœäŸ 32
ïŒïŒ11âãžãããâ11âã¢ãããžãã³ãºãïœïŒ
ïœ ããªãã»ãã³âïŒâã«ã«ãã³é žã¡ãã«ãšã¹ã
ã«å¡©é žå¡© 600mgã®ïŒïŒ11âãžãããâ11âãã«ã ã¢ãã
ãžãã³ãºãïœïŒïœ ããªãã»ãã³âïŒâã«ã«ãã³é ž
ã¡ãã«ãšã¹ãã«ã20mlã®ãžãªããµã³ãš24mlã®10ïŒ
å¡©é žãšã®æ··åç©ã«æ·»å ãããæ··åç©ã40âã«ãã
ãŠ18æéå ç±æ¹æãããèžçºä¹ŸåºåŸãæ®æž£ããã
ã©ããããã©ã³äžã§ç²ç ãããåºåœ¢åãå¥ãã
æ°Žã«æº¶è§£ããæ°Žé žåãããªãŠã 氎溶液ã§å¡©åºæ§ã«
ããããšãŒãã«äžã«æœåºããç¡æ°Žç¡«é žãããªãŠã
äžã§ä¹Ÿç¥ãããéããã溶液äžã«ã¬ã¹ç¶ã®å¡©å
æ°ŽçŽ ã15åéå¹èŸŒã¿åºåœ¢åãåé¢ãããããã©ã
ãããã©ã³äžã§ç²ç ããéãè¡ã€ãŠç®ççæç©
ãåŸãïŒèç¹224âãå解ïŒã
ïœ ããªãã»ãã³âïŒâã«ã«ãã³é žã¡ãã«ãšã¹ã
ã«å¡©é žå¡© 600mgã®ïŒïŒ11âãžãããâ11âãã«ã ã¢ãã
ãžãã³ãºãïœïŒïœ ããªãã»ãã³âïŒâã«ã«ãã³é ž
ã¡ãã«ãšã¹ãã«ã20mlã®ãžãªããµã³ãš24mlã®10ïŒ
å¡©é žãšã®æ··åç©ã«æ·»å ãããæ··åç©ã40âã«ãã
ãŠ18æéå ç±æ¹æãããèžçºä¹ŸåºåŸãæ®æž£ããã
ã©ããããã©ã³äžã§ç²ç ãããåºåœ¢åãå¥ãã
æ°Žã«æº¶è§£ããæ°Žé žåãããªãŠã 氎溶液ã§å¡©åºæ§ã«
ããããšãŒãã«äžã«æœåºããç¡æ°Žç¡«é žãããªãŠã
äžã§ä¹Ÿç¥ãããéããã溶液äžã«ã¬ã¹ç¶ã®å¡©å
æ°ŽçŽ ã15åéå¹èŸŒã¿åºåœ¢åãåé¢ãããããã©ã
ãããã©ã³äžã§ç²ç ããéãè¡ã€ãŠç®ççæç©
ãåŸãïŒèç¹224âãå解ïŒã
å®æœäŸ 33
ïŒïŒ11âãžãããâ11âã¢ãããžãã³ãºãïœïŒ
ïœ ããªãã»ãã³âïŒâã«ã«ãã³é žå¡©é žå¡© 340mgã®ïŒïŒ11âãžãããâ11âãã«ã ã¢ãã
ãžãã³ãºãïœïŒïœ ããªãã»ãã³âïŒâã«ã«ãã³é ž
ã¡ãã«ãšã¹ãã«ã10mlã®ãžãªããµã³åã³10mlã®æ¿
å¡©é žã100âã«ãããŠïŒæéäžç·ã«å ç±ãããèž
çºä¹ŸåºããŠæ®æž£ãæ°Žã«æº¶è§£ãããã€ãªâã©ãã
ïŒBioâRadïŒAGâ50WâX8æš¹èïŒã¹ã«ãã³é ž
åïŒãééãããã10ïŒ ã®æ°Žé žåã¢ã³ã¢ããŠã 溶
液ã§æº¶é¢ããŠé žãæ¡éãããèžçºä¹ŸåºããŠæ®æž£ã
ããã©ããããã©ã³ã«æº¶è§£ããå¡©é žæ°Žæº¶æ¶²ã§é žæ§
ã«ãããèžçºä¹ŸåºããŠã¡ã¿ããŒã«ïŒãšã¿ããŒã«ã
ãåçµæ¶ãããŠç®ççæç©ãåŸãïŒèç¹245âã
å解ïŒã
ïœ ããªãã»ãã³âïŒâã«ã«ãã³é žå¡©é žå¡© 340mgã®ïŒïŒ11âãžãããâ11âãã«ã ã¢ãã
ãžãã³ãºãïœïŒïœ ããªãã»ãã³âïŒâã«ã«ãã³é ž
ã¡ãã«ãšã¹ãã«ã10mlã®ãžãªããµã³åã³10mlã®æ¿
å¡©é žã100âã«ãããŠïŒæéäžç·ã«å ç±ãããèž
çºä¹ŸåºããŠæ®æž£ãæ°Žã«æº¶è§£ãããã€ãªâã©ãã
ïŒBioâRadïŒAGâ50WâX8æš¹èïŒã¹ã«ãã³é ž
åïŒãééãããã10ïŒ ã®æ°Žé žåã¢ã³ã¢ããŠã 溶
液ã§æº¶é¢ããŠé žãæ¡éãããèžçºä¹ŸåºããŠæ®æž£ã
ããã©ããããã©ã³ã«æº¶è§£ããå¡©é žæ°Žæº¶æ¶²ã§é žæ§
ã«ãããèžçºä¹ŸåºããŠã¡ã¿ããŒã«ïŒãšã¿ããŒã«ã
ãåçµæ¶ãããŠç®ççæç©ãåŸãïŒèç¹245âã
å解ïŒã
å®æœäŸ 34
ïŒïŒ11âãžãããâ11âãã«ã ã¢ãããžãã³ãº
ãïœïŒïœ ããªãã»ãã³âïŒâã«ã«ãã³é ž 1.77ïœïŒïŒããªã¢ã«ïŒã®ïŒïŒ11âãžãããâ11
âã¢ãããžãã³ãºãïœïŒïœ ããªãã»ãã³âïŒâã«
ã«ãã³é žã®ïŒmlã®90ïŒ ã®é žäžã®æ··åç©ã«1.5ïœã®
ç¡æ°Žé ¢é žâã®é žã10âã«ãããŠæ¹æããªããæ·»å
ãããç¡æ°Žé ¢é žâã®é žã¯L.ã ã©ãããã®æ¹æ³ïŒæ¥
æ¬ååŠäŒèª38ïŒ244ïŒ1965幎ïŒã«ãã€ãŠäœãã
ãããïŒæéåŸæ··åç©ã宀枩ãŸã§æž©ããïŒæéæ¹
æãç¶ç¶ãããæ®çºåãç空èžçºãããŠç®ççæ
ç©ãåŸãã
ãïœïŒïœ ããªãã»ãã³âïŒâã«ã«ãã³é ž 1.77ïœïŒïŒããªã¢ã«ïŒã®ïŒïŒ11âãžãããâ11
âã¢ãããžãã³ãºãïœïŒïœ ããªãã»ãã³âïŒâã«
ã«ãã³é žã®ïŒmlã®90ïŒ ã®é žäžã®æ··åç©ã«1.5ïœã®
ç¡æ°Žé ¢é žâã®é žã10âã«ãããŠæ¹æããªããæ·»å
ãããç¡æ°Žé ¢é žâã®é žã¯L.ã ã©ãããã®æ¹æ³ïŒæ¥
æ¬ååŠäŒèª38ïŒ244ïŒ1965幎ïŒã«ãã€ãŠäœãã
ãããïŒæéåŸæ··åç©ã宀枩ãŸã§æž©ããïŒæéæ¹
æãç¶ç¶ãããæ®çºåãç空èžçºãããŠç®ççæ
ç©ãåŸãã
å®æœäŸ 35
11âããããã·â11âã¡ãã«âïŒïŒ11âãžãã
ããžãã³ãºãïœïŒïœ ããªãã»ãã³âïŒâã«ã«ã
ã³é ž å·¥çšïŒ¡ïŒ11âããããã·â11âã¡ãã«âïŒïŒ11â
ãžããããžãã³ãºãïœïŒïœ ããªãã»ãã³âïŒâ
ã«ã«ãã³é žã¡ãã«ãšã¹ãã« 268mgïŒïŒããªã¢ã«ïŒã®ïŒïŒ11âãžãããâ11
âãªããœãžãã³ãºãïœïŒïœ ããªãã»ãã³âïŒâã«
ã«ãã³é žã15mlã®ããã©ããããã©ã³ã«æº¶è§£ã
ããã¡ãã«ãšãŠåãã°ãã·ãŠã ã®ãšãŒãã«æº¶æ¶²ã
å°ããã€èå±€ã¯ãããã°ã©ãã«ããåºçºã«ã«ãã³
é žã埮éã«ãªãããšã瀺ããããŸã§æ·»å ãããèµ€
è²æº¶æ¶²ãèµ€è²ãæ¶ãããŸã§çšå¡©é žæ°Žæº¶æ¶²ã§é žæ§ã«
ããããšãŒãã«ã§æœåºãè¡ã€ãŠææ©å±€ãåé¢ããŠ
ã·ãªã«ã²ã«äžã§ïŒïŒ é ¢é žãšãã«ïŒãã³ãŒã³ã§æº¶è§£
ãããŠã¯ãããã°ã©ããè¡ãç®ççæç©ãåŸãã
ããžãã³ãºãïœïŒïœ ããªãã»ãã³âïŒâã«ã«ã
ã³é ž å·¥çšïŒ¡ïŒ11âããããã·â11âã¡ãã«âïŒïŒ11â
ãžããããžãã³ãºãïœïŒïœ ããªãã»ãã³âïŒâ
ã«ã«ãã³é žã¡ãã«ãšã¹ãã« 268mgïŒïŒããªã¢ã«ïŒã®ïŒïŒ11âãžãããâ11
âãªããœãžãã³ãºãïœïŒïœ ããªãã»ãã³âïŒâã«
ã«ãã³é žã15mlã®ããã©ããããã©ã³ã«æº¶è§£ã
ããã¡ãã«ãšãŠåãã°ãã·ãŠã ã®ãšãŒãã«æº¶æ¶²ã
å°ããã€èå±€ã¯ãããã°ã©ãã«ããåºçºã«ã«ãã³
é žã埮éã«ãªãããšã瀺ããããŸã§æ·»å ãããèµ€
è²æº¶æ¶²ãèµ€è²ãæ¶ãããŸã§çšå¡©é žæ°Žæº¶æ¶²ã§é žæ§ã«
ããããšãŒãã«ã§æœåºãè¡ã€ãŠææ©å±€ãåé¢ããŠ
ã·ãªã«ã²ã«äžã§ïŒïŒ é ¢é žãšãã«ïŒãã³ãŒã³ã§æº¶è§£
ãããŠã¯ãããã°ã©ããè¡ãç®ççæç©ãåŸãã
å·¥çšïŒ¢ïŒ11âããããã·â11âã¡ãã«âïŒïŒ11â
ãžããããžãã³ãºãïœïŒïœ ããªãã»ãã³âïŒâ
ã«ã«ãã³é ž 11âããããã·â11âã¡ãã«âïŒïŒ11âãžãã
ããã³ãºãïœïŒïœ ããªãã»ãã³âïŒâã«ã«ãã³é ž
ã¡ãã«ãšã¹ãã«450mgã20mlã®ãšã¿ããŒã«ã«æº¶è§£
ãã20mlã®ïŒïŒ æ°Žé žåãããªãŠã 氎溶液ãæ·»å ã
ãã宀枩ã«ãããŠïŒæéæ¹æãããã¢ã«ã³ãŒã«ã
çå»ããæ®çãããªãŠã 塩溶液ã40mlã®æ°Žã§çšé
ããã氷济äžã§å·åŽã5Nå¡©é žã§é žæ§ã«ãããåº
圢åãå¥åé¢ããŠä¹Ÿç¥ãããïŒåé250mgïŒãã
ã³ãŒã³ããåçµæ¶ãããŠç®ççæç©ãåŸãïŒåé
200mgãèç¹258âïŒã
ãžããããžãã³ãºãïœïŒïœ ããªãã»ãã³âïŒâ
ã«ã«ãã³é ž 11âããããã·â11âã¡ãã«âïŒïŒ11âãžãã
ããã³ãºãïœïŒïœ ããªãã»ãã³âïŒâã«ã«ãã³é ž
ã¡ãã«ãšã¹ãã«450mgã20mlã®ãšã¿ããŒã«ã«æº¶è§£
ãã20mlã®ïŒïŒ æ°Žé žåãããªãŠã 氎溶液ãæ·»å ã
ãã宀枩ã«ãããŠïŒæéæ¹æãããã¢ã«ã³ãŒã«ã
çå»ããæ®çãããªãŠã 塩溶液ã40mlã®æ°Žã§çšé
ããã氷济äžã§å·åŽã5Nå¡©é žã§é žæ§ã«ãããåº
圢åãå¥åé¢ããŠä¹Ÿç¥ãããïŒåé250mgïŒãã
ã³ãŒã³ããåçµæ¶ãããŠç®ççæç©ãåŸãïŒåé
200mgãèç¹258âïŒã
å®æœäŸ 36
11âã¡ãã¬ã³âïŒïŒ11âãžããããã³ãºãïœïŒ
ïœ ããªãã»ãã³âïŒâã«ã«ãã³é ž å·¥çšïŒ¡ïŒ11âã¡ãã¬ã³âïŒïŒ11âãžããããžãã³
ãºãïœïŒïœ ããªãã»ãã³âïŒâã«ã«ãã³é žã¡ã
ã«ãšã¹ãã« ïŒïœã®11âããããã·â11âã¡ãã«âïŒïŒ11â
ãžããããžãã³ãºãïœïŒïœ ããªãã»ãã³âïŒâã«
ã«ãã³é žã¡ãã«ãšã¹ãã«ãå°éã®ïœâãã«ãšã³ã¹
ã«ãã³é žçµæ¶ãå«æãããã³ãŒã³100mlã«10åé
ã§æº¶è§£ããããåå¿æ¶²ãèžçºä¹ŸåºãããŠç®ççæ
ç©ãåŸãã
ïœ ããªãã»ãã³âïŒâã«ã«ãã³é ž å·¥çšïŒ¡ïŒ11âã¡ãã¬ã³âïŒïŒ11âãžããããžãã³
ãºãïœïŒïœ ããªãã»ãã³âïŒâã«ã«ãã³é žã¡ã
ã«ãšã¹ãã« ïŒïœã®11âããããã·â11âã¡ãã«âïŒïŒ11â
ãžããããžãã³ãºãïœïŒïœ ããªãã»ãã³âïŒâã«
ã«ãã³é žã¡ãã«ãšã¹ãã«ãå°éã®ïœâãã«ãšã³ã¹
ã«ãã³é žçµæ¶ãå«æãããã³ãŒã³100mlã«10åé
ã§æº¶è§£ããããåå¿æ¶²ãèžçºä¹ŸåºãããŠç®ççæ
ç©ãåŸãã
å·¥çšïŒ¢ïŒ11âã¡ãã¬ã³âïŒïŒ11âãžããããžãã³
ãºãïœïŒïœ ããªãã»ãã³âïŒâã«ã«ãã³é ž äžèšå·¥çšïŒ¡ã®æ®æž£ã40mlã®ãšã¿ããŒã«äžã«æž©ã
ãªãã溶解ãããå·åŽããŠ40mlã®20ïŒ æ°Žé žåãã
ãªãŠã 溶液ãæ·»å ãããïŒæéæŸçœ®ããŠã¢ã«ã³ãŒ
ã«ãçå»ãããæ°Žã§çšéåŸ5Nå¡©é žã§é žæ§ã«ããã
åºåœ¢åãå¥åé¢ããŠã也ç¥ããç®ççæç©ãåŸ
ãïŒåé850mgïŒããšã¿ããŒã«ããåçµæ¶ãããŠç²Ÿ
補ããïŒèç¹255ã257âïŒã
ãºãïœïŒïœ ããªãã»ãã³âïŒâã«ã«ãã³é ž äžèšå·¥çšïŒ¡ã®æ®æž£ã40mlã®ãšã¿ããŒã«äžã«æž©ã
ãªãã溶解ãããå·åŽããŠ40mlã®20ïŒ æ°Žé žåãã
ãªãŠã 溶液ãæ·»å ãããïŒæéæŸçœ®ããŠã¢ã«ã³ãŒ
ã«ãçå»ãããæ°Žã§çšéåŸ5Nå¡©é žã§é žæ§ã«ããã
åºåœ¢åãå¥åé¢ããŠã也ç¥ããç®ççæç©ãåŸ
ãïŒåé850mgïŒããšã¿ããŒã«ããåçµæ¶ãããŠç²Ÿ
補ããïŒèç¹255ã257âïŒã
å®æœäŸ 37
11âã¡ãã«âïŒïŒ11âãžããããžãã³ãºãïœïŒ
ïœ ããªãã»ãã³âïŒâã«ã«ãã³é ž 514ïœã®11âã¡ãã¬ã³âïŒïŒ11âãžããããžã
ã³ãºãïœïŒïœ ããªãã»ãã³âïŒâã«ã«ãã³é žã
150mlã®ãšã¿ããŒã«äžã«æº¶è§£ããã100mgã®ïŒïŒ ã
ã©ãžãŠã âççŽ è§Šåªãæ·»å ããã20psiïŒçŽ1.4
KgïŒcm2ïŒã«ãããŠæ°ŽçŽ æ·»å ã30åéè¡ãïŒãé
ãè¡ãã液ãèžçºä¹Ÿåºããããæ®æž£ãã€ãœãã
ãããŒã«ããåçµæ¶ãããŠç®ççæç©ãåŸãïŒå
é365mgãèç¹224ã226âïŒã
ïœ ããªãã»ãã³âïŒâã«ã«ãã³é ž 514ïœã®11âã¡ãã¬ã³âïŒïŒ11âãžããããžã
ã³ãºãïœïŒïœ ããªãã»ãã³âïŒâã«ã«ãã³é žã
150mlã®ãšã¿ããŒã«äžã«æº¶è§£ããã100mgã®ïŒïŒ ã
ã©ãžãŠã âççŽ è§Šåªãæ·»å ããã20psiïŒçŽ1.4
KgïŒcm2ïŒã«ãããŠæ°ŽçŽ æ·»å ã30åéè¡ãïŒãé
ãè¡ãã液ãèžçºä¹Ÿåºããããæ®æž£ãã€ãœãã
ãããŒã«ããåçµæ¶ãããŠç®ççæç©ãåŸãïŒå
é365mgãèç¹224ã226âïŒã
å®æœäŸ 38
ïŒïŒ11âãžãããâ11âãšããªãã³ãžãã³ãº
ãïœïŒïœ ããªãã»ãã³âïŒâã«ã«ãã³é ž å·¥çšïŒ¡ïŒïŒâã·ã¢ãâïŒïŒ11âãžãããâ11âãš
ããªãã³ãžãã³ãºãïœïŒïœ ããªãã»ãã³ 23.6ïœã®ãšãã«ããªããšãã«ãã¹ãããŠã ãã
ãã€ãã200mlã®ä¹Ÿç¥ããã©ããããã©ã³äžã«æž
æ¿ããã24mlã®ïœâããã«ãªããŠã ã®ãããµã³æº¶
液ãæ¹æããªãã宀枩ã§çªçŽ é°å²æ°äžã«æ»Žäžã
ããïŒæéæ¹æãç¶ãã次ãã§ãã©ã€ã¢ã€ã¹æµŽå
ã§â70âã«å·åŽããã10ïœã®ïŒâã·ã¢ãâïŒïŒ11
âãžãããâ11âãªããœãžãã³ãºãïœïŒïœ ããªã
ã»ãã³ã®ä¹Ÿç¥ããã©ããããã©ã³75ml溶液ã30å
éã«äºã€ãŠæ»Žäžãããæ¹æãâ70âã«ãããŠ30å
éç¶ã宀枩ãŸã§æž©ãæŽã«äžæ©çªçŽ é°å²æ°äžã«æ¹æ
ãç¶ãããåå¿æ¶²ã400mlã®ãšãŒãã«ã«æ³šãã
éããŠæ¶²ã飜åå¡©åãããªãŠã 氎溶液ã§æŽæµã
ããç¡æ°Žç¡«é žãã°ãã·ãŠã äžã§ä¹Ÿç¥ãããèžçºä¹Ÿ
åºããããæ®æž£ãã·ãªã«ã²ã«äžã§ïŒïŒ é ¢é žãšãã«
ã®ãããµã³ã§æº¶é¢ãããŠã¯ãããã°ã©ããè¡ãã
æçµçæç©ãåŸãïŒ5.73ïœïŒã
ãïœïŒïœ ããªãã»ãã³âïŒâã«ã«ãã³é ž å·¥çšïŒ¡ïŒïŒâã·ã¢ãâïŒïŒ11âãžãããâ11âãš
ããªãã³ãžãã³ãºãïœïŒïœ ããªãã»ãã³ 23.6ïœã®ãšãã«ããªããšãã«ãã¹ãããŠã ãã
ãã€ãã200mlã®ä¹Ÿç¥ããã©ããããã©ã³äžã«æž
æ¿ããã24mlã®ïœâããã«ãªããŠã ã®ãããµã³æº¶
液ãæ¹æããªãã宀枩ã§çªçŽ é°å²æ°äžã«æ»Žäžã
ããïŒæéæ¹æãç¶ãã次ãã§ãã©ã€ã¢ã€ã¹æµŽå
ã§â70âã«å·åŽããã10ïœã®ïŒâã·ã¢ãâïŒïŒ11
âãžãããâ11âãªããœãžãã³ãºãïœïŒïœ ããªã
ã»ãã³ã®ä¹Ÿç¥ããã©ããããã©ã³75ml溶液ã30å
éã«äºã€ãŠæ»Žäžãããæ¹æãâ70âã«ãããŠ30å
éç¶ã宀枩ãŸã§æž©ãæŽã«äžæ©çªçŽ é°å²æ°äžã«æ¹æ
ãç¶ãããåå¿æ¶²ã400mlã®ãšãŒãã«ã«æ³šãã
éããŠæ¶²ã飜åå¡©åãããªãŠã 氎溶液ã§æŽæµã
ããç¡æ°Žç¡«é žãã°ãã·ãŠã äžã§ä¹Ÿç¥ãããèžçºä¹Ÿ
åºããããæ®æž£ãã·ãªã«ã²ã«äžã§ïŒïŒ é ¢é žãšãã«
ã®ãããµã³ã§æº¶é¢ãããŠã¯ãããã°ã©ããè¡ãã
æçµçæç©ãåŸãïŒ5.73ïœïŒã
å·¥çšïŒ¢ïŒïŒïŒ11âãžãããâ11âãšããªãã³ãžã
ã³ãºãïœïŒïœ ããªãã»ãã³âïŒâã«ã«ãã³é ž 2.8ïœã®å·¥çšïŒ¡ã®ãããªã«ã50mlã®é ¢é žåã³ïŒ
mlã®æ°Žåã³ïŒmlã®æ¿å¡©é žã®æ··åç©ã140æééæµ
ããããåå¿æ¶²ãå·åŽããåºåœ¢åãå¥åé¢ããŠ
也ç¥ãããããã«ãšã³ããåçµæ¶åãããŠç®çç
æç©ãåŸãã
ã³ãºãïœïŒïœ ããªãã»ãã³âïŒâã«ã«ãã³é ž 2.8ïœã®å·¥çšïŒ¡ã®ãããªã«ã50mlã®é ¢é žåã³ïŒ
mlã®æ°Žåã³ïŒmlã®æ¿å¡©é žã®æ··åç©ã140æééæµ
ããããåå¿æ¶²ãå·åŽããåºåœ¢åãå¥åé¢ããŠ
也ç¥ãããããã«ãšã³ããåçµæ¶åãããŠç®çç
æç©ãåŸãã
å·¥çšïŒ¡ã§çšãããšãã«ããªããšãã«ãã¹ãããŠ
ã ãããã€ãã®ä»£ãã«å¥ã®äœçŽã¢ã«ãã«ããªããš
ãã«ãã¹ãããŠã ãããã€ããäŸãã°ãããã«ã
ã€ãœãããã«ãããã¯ïœâããã«ããªããšãã«ã
ã¹ãããŠã ãããã€ããããã¯ãã³ãžã«ãããã¯
ç°çœ®æãã³ãžã«ããªããšãã«ãã¹ãããŠã ããã
ã€ããªã©ãçšããããšã«ãã察å¿ãã11âäœçŽã¢
ã«ãã«ãã³ãããã¯11âãã³ãžã«ãã³èªå°äœãåŸ
ããããåã察å¿ããïŒâã·ã¢ãâ11âãªããœãž
ãã³ãºãïœïŒïœ ããªãã»ãã³ãåºçºç©è³ªãšããŠçš
ããããå Žåã«ã¯å¯Ÿå¿ããïŒâã«ã«ãã³é žãåŸã
ããããããã®ååç©ã次ãã§äžèšã®åŠãéå ã
ãããšã«ãã察å¿ãã11âäœçŽã¢ã«ãã«ãããã¯
11âãã«ã€ã«èªå°äœã圢æããããšãã§ããã
ã ãããã€ãã®ä»£ãã«å¥ã®äœçŽã¢ã«ãã«ããªããš
ãã«ãã¹ãããŠã ãããã€ããäŸãã°ãããã«ã
ã€ãœãããã«ãããã¯ïœâããã«ããªããšãã«ã
ã¹ãããŠã ãããã€ããããã¯ãã³ãžã«ãããã¯
ç°çœ®æãã³ãžã«ããªããšãã«ãã¹ãããŠã ããã
ã€ããªã©ãçšããããšã«ãã察å¿ãã11âäœçŽã¢
ã«ãã«ãã³ãããã¯11âãã³ãžã«ãã³èªå°äœãåŸ
ããããåã察å¿ããïŒâã·ã¢ãâ11âãªããœãž
ãã³ãºãïœïŒïœ ããªãã»ãã³ãåºçºç©è³ªãšããŠçš
ããããå Žåã«ã¯å¯Ÿå¿ããïŒâã«ã«ãã³é žãåŸã
ããããããã®ååç©ã次ãã§äžèšã®åŠãéå ã
ãããšã«ãã察å¿ãã11âäœçŽã¢ã«ãã«ãããã¯
11âãã«ã€ã«èªå°äœã圢æããããšãã§ããã
æ¬çºæã¯åèšæ现æžäžã«ãããŠãæ¬æ现æžäžã«
é瀺ããããªãã»ãã³ã®éå°ãªæãŸãããªããã
ã¹ã¿ã°ã©ã³ãžã³åã³ããã¹ã¿ã°ã©ã³ãžã³çåæäž
éäœåã³ç¹ã«åæ¯ã®éå°ãªæãŸãããªãåçž®æ§ã®
掻åã«ãã€ãŠç¹åŸŽã¥ããããããåã³æž©è¡åç©ã®
ç æ ã®æ²»çåã³æå¶ã«ãããçšéã«ã€ããŠèª¬æã
è¡ã€ãããåçž®æ§ããã¹ã¿ã°ã©ã³ãžã³é¡ã®æ ¢æ§é»
害çèºç ïŒäŸãã°åæ¯ïŒãžã®é¢äžã®å€ã«ããã¹ã¿
ã°ã©ã³ãžã³é¡ã¯ãã®ä»ã®ã¢ã¬ã«ã®ãŒæ§ç¶æ ãªãã³
ã«ççãäžç¢ãé«è¡å§ãã¢ã³ã®ããè¡å°æ¿åéã
倧è³ãããããæ©ææµç£åã³æçµäžé ãªã©ã«ã圹
å²ãæŒããããšã¯åœæ¥è ã®åšç¥ã®ããšã§ããã
åãæ¬çºæã®ãªãã»ãã³é¡ã¯åŒ·åãªè¡å°æ¿åéã
é»æ¢ããTXA2çåæé²æ¢å€ã§ãããã¢ãããŒã
æ§åè硬ååã³å¿çæ¢å¡ã®ãããªç æ°ã«ãããŠã
éèŠã§ãããæ¬åºé¡äººã¯è²ã«é瀺ãããç¹èš±è«æ±
ãããŠãããªãã»ãã³ã®ãããã®ç æ ãžã®é©çšã¯
æ¬é¡ã«ãã€ãŠé瀺ãããŠããçºæã®èªæã®åçç©
ã§ãããæ¬é¡çºæã®ç¯å²å ã«å«ãŸãããã®ãšèã
ãŠããã
é瀺ããããªãã»ãã³ã®éå°ãªæãŸãããªããã
ã¹ã¿ã°ã©ã³ãžã³åã³ããã¹ã¿ã°ã©ã³ãžã³çåæäž
éäœåã³ç¹ã«åæ¯ã®éå°ãªæãŸãããªãåçž®æ§ã®
掻åã«ãã€ãŠç¹åŸŽã¥ããããããåã³æž©è¡åç©ã®
ç æ ã®æ²»çåã³æå¶ã«ãããçšéã«ã€ããŠèª¬æã
è¡ã€ãããåçž®æ§ããã¹ã¿ã°ã©ã³ãžã³é¡ã®æ ¢æ§é»
害çèºç ïŒäŸãã°åæ¯ïŒãžã®é¢äžã®å€ã«ããã¹ã¿
ã°ã©ã³ãžã³é¡ã¯ãã®ä»ã®ã¢ã¬ã«ã®ãŒæ§ç¶æ ãªãã³
ã«ççãäžç¢ãé«è¡å§ãã¢ã³ã®ããè¡å°æ¿åéã
倧è³ãããããæ©ææµç£åã³æçµäžé ãªã©ã«ã圹
å²ãæŒããããšã¯åœæ¥è ã®åšç¥ã®ããšã§ããã
åãæ¬çºæã®ãªãã»ãã³é¡ã¯åŒ·åãªè¡å°æ¿åéã
é»æ¢ããTXA2çåæé²æ¢å€ã§ãããã¢ãããŒã
æ§åè硬ååã³å¿çæ¢å¡ã®ãããªç æ°ã«ãããŠã
éèŠã§ãããæ¬åºé¡äººã¯è²ã«é瀺ãããç¹èš±è«æ±
ãããŠãããªãã»ãã³ã®ãããã®ç æ ãžã®é©çšã¯
æ¬é¡ã«ãã€ãŠé瀺ãããŠããçºæã®èªæã®åçç©
ã§ãããæ¬é¡çºæã®ç¯å²å ã«å«ãŸãããã®ãšèã
ãŠããã
æ¬åºé¡äººãçºæãšèããŠããäž»é¡åã³è²ã«ç¹èš±
è«æ±ãããŠããäž»é¡ã¯ãç¹ã«ç¹èš±è«æ±ã®ç¯å²ã«ã
ããŠææããæ確ã«èšèŒãããŠããã
è«æ±ãããŠããäž»é¡ã¯ãç¹ã«ç¹èš±è«æ±ã®ç¯å²ã«ã
ããŠææããæ確ã«èšèŒãããŠããã
Claims (1)
- ãç¹èš±è«æ±ã®ç¯å²ã ïŒ åŒ ãåŒäžãR1åã³R3ã¯ç¬ç«çã«æ°ŽçŽ ãã«ã«ããã·ã
äœçŽã¢ã«ã³ãã·ã«ã«ããã«ãïŒâããã©ãŸãªã«ã
ïŒâããããã·âïŒïŒïŒïŒïŒâãã¢ãžã¢ãŸãŒã«â
ïŒâã€ã«ãïŒâããããã·âÎ3âãããªã³âïŒïŒ
ïŒâãžãªã³âïŒâã€ã«åã¯ïŒïŒ®âã¡ãã«âïŒâã
ã¢ãŸãªãžããªãã³ïŒã«ã«ãã¢ã€ã«ã§ããããã®
éãR1ãšR3ã®äžæ¹ã¯æ°ŽçŽ ã§ãããä»æ¹ã¯æ°ŽçŽ 以
å€ã§ããïŒ R2ã¯æ°ŽçŽ åã¯äœçŽã¢ã«ãã«ã§ããããåã¯R1
ãšR2ãäžç·ã«ãªã€ãŠã¡ãã¬ã³ãžãªãã·ã圢æã
ãïŒ R4ã¯æ°ŽçŽ ãããããã·ãäœçŽã¢ã«ãã«ã¹ã«ã
ãã«ãäœçŽã¢ã«ãã«ããªãäœçŽã¢ã«ã³ãã·ãã€ã
ããŸãªã«åã¯ã¢ããã§ããããåã¯R4ãšR5ã¯äž
ç·ã«ãªã€ãŠïŒïŒ¯åã¯ïŒCH2ã圢æãããã®éã
R4ãšR5ãšãïŒïŒ¯ã圢æãããããŠR2ãšR3ãšãæ°Ž
çŽ ã®å Žåã«ãR1ã¯ïŒâããã©ãŸãªã«åã³ã«ã«ã
ãã·ä»¥å€ã®ãã®ã§ãããã®ååç©åã¯ãã®è¬åŠç
ã«èš±å®¹ãããå¡©ã ïŒ R4ãäœçŽã¢ã«ã³ãã·ãäœçŽã¢ã«ãã«ããªã
äœçŽã¢ã«ãã«ã¹ã«ããã«ãåã¯ã¢ããã§ããR5
ãæ°ŽçŽ ã§ããå ŽåïŒR4ãæ°ŽçŽ ã§ããR5ãäœçŽã¢
ã«ãã«ã§ããå ŽåïŒåã¯R4åã³R5ãäžç·ã«ãªã€
ãŠã¡ãã¬ã³ã§ããç¹èš±è«æ±ã®ç¯å²ç¬¬ïŒé ã®åå
ç©ã ïŒ R4ãã¡ããã·ãã¡ãã«ããªãã¡ãã«ã¹ã«ã
ãã«åã³ã¢ãããããªã矀ããéžæããããã®ã§
ãããR5ãæ°ŽçŽ ã§ããå ŽåïŒR4ãæ°ŽçŽ ã§ããR5
ãã¡ãã«ã§ããå ŽåïŒåã¯R4åã³R5ãäžç·ã«çµ
åããŠã¡ãã¬ã³ã§ããå Žåã§R2åã³R3ãæ°ŽçŽ ã§
ããããããŠR1ãïŒâããã©ãŸãªã«åã³ã«ã«ã
ãã·ãããªã矀ããéžæããããã®ã§ããç¹èš±è«
æ±ã®ç¯å²ç¬¬ïŒé èšèŒã®ååç©ã ïŒ R1ãïŒâããã©ãŸãªã«ã§ãããR4ãæ°ŽçŽ ã§
ããããããŠR5ãã¡ãã«ã§ããç¹èš±è«æ±ã®ç¯å²
第ïŒé èšèŒã®ååç©ã ïŒ R1ãïŒâããã©ãŸãªã«ã§ããããããŠR4å
ã³R5ãäžç·ã«çµåããŠã¡ãã¬ã³ã§ããç¹èš±è«æ±
ã®ç¯å²ç¬¬ïŒé èšèŒã®ååç©ã ïŒ R1ãïŒâããã©ãŸãªã«ã§ãããR4ãã¡ãã«
ããªã§ããããããŠR5ãæ°ŽçŽ ã§ããç¹èš±è«æ±ã®
ç¯å²ç¬¬ïŒé èšèŒã®ååç©ã ïŒ R1ãïŒâããã©ãŸãªã«ã§ãããR4ãã¡ãã«
ã¹ã«ããã«ã§ããããããŠR5ãæ°ŽçŽ ã§ããç¹èš±
è«æ±ã®ç¯å²ç¬¬ïŒé èšèŒã®ååç©ã ïŒ R1ãïŒâããã©ãŸãªã«ã§ãããR4ãã¡ãã
ã·ã§ããããããŠR5ãæ°ŽçŽ ã§ããç¹èš±è«æ±ã®ç¯
å²ç¬¬ïŒé èšèŒã®ååç©ã ïŒ R1ãïŒâããã©ãŸãªã«ã§ãããR4ãã¢ãã
ã§ããããããŠR5ãæ°ŽçŽ ã§ããç¹èš±è«æ±ã®ç¯å²
第ïŒé èšèŒã®ååç©ã ïŒïŒ R1ãã«ã«ããã·ã§ãããR4ãæ°ŽçŽ ã§ããã
ãããŠR5ãã¡ãã«ã§ããç¹èš±è«æ±ã®ç¯å²ç¬¬ïŒé
èšèŒã®ååç©ã ïŒïŒ R1ãã«ã«ããã·ã§ããããããŠR4åã³R5
äžç·ã«çµåããŠã¡ãã¬ã³ã§ããç¹èš±è«æ±ã®ç¯å²ç¬¬
ïŒé èšèŒã®ååç©ã ïŒïŒ R1ãã«ã«ããã·ã§ãããR4ãã¡ãã«ããª
ã§ããããããŠR5ãæ°ŽçŽ ã§ããç¹èš±è«æ±ã®ç¯å²
第ïŒé èšèŒã®ååç©ã ïŒïŒ R1ãã«ã«ããã·ã§ãããR4ãã¡ãã«ã¹ã«
ããã«ã§ããããããŠR5ãæ°ŽçŽ ã§ããç¹èš±è«æ±
ã®ç¯å²ç¬¬ïŒé èšèŒã®ååç©ã ïŒïŒ R1ãã«ã«ããã·ã§ãããR4ãã¡ããã·ã§
ããããããŠR5ãæ°ŽçŽ ã§ããç¹èš±è«æ±ã®ç¯å²ç¬¬
ïŒé èšèŒã®ååç©ã ïŒïŒ R1ãã«ã«ããã·ã§ãããR4ãã¢ããã§ã
ãããããŠR5ãæ°ŽçŽ ã§ããç¹èš±è«æ±ã®ç¯å²ç¬¬ïŒ
é èšèŒã®ååç©ã ïŒïŒ åŒ ãåŒäžãR1åã³R3ã¯ç¬ç«çã«æ°ŽçŽ ãã«ã«ããã·ã
äœçŽã¢ã«ã³ãã·ã«ã«ããã«ãïŒâããã©ãŸãªã«ã
ïŒâããããã·âïŒïŒïŒïŒïŒâãã¢ãžã¢ãŸãŒã«â
ïŒâã€ã«ãïŒâããããã·âÎ3âãããªã³âïŒïŒ
ïŒâãžãªã³âïŒâã€ã«åã¯ïŒïŒ®âã¡ãã«âïŒâã
ã¢ãŸãªãžããªãã³ïŒã«ã«ãã¢ã€ã«ã§ããããã®
éãR1ãšR3ã®äžæ¹ã¯æ°ŽçŽ ã§ãããä»æ¹ã¯æ°ŽçŽ 以
å€ã§ããïŒ R2ã¯æ°ŽçŽ åã¯äœçŽã¢ã«ãã«ã§ããããåã¯R1
ãšR2ãäžç·ã«ãªã€ãŠã¡ãã¬ã³ãžãªãã·ã圢æã
ãïŒ R4ã¯æ°ŽçŽ ãããããã·ãäœçŽã¢ã«ãã«ã¹ã«ã
ãã«ãäœçŽã¢ã«ãã«ããªãäœçŽã¢ã«ã³ãã·ãã€ã
ããŸãªã«åã¯ã¢ããã§ããããåã¯R4ãšR5ã¯äž
ç·ã«ãªã€ãŠïŒïŒ¯åã¯ïŒCH2ã圢æãããã®éã
R4ãšR5ãšãïŒïŒ¯ã圢æãããããŠR2ãšR3ãšãæ°Ž
çŽ ã®å Žåã«ãR1ã¯ïŒâããã©ãŸãªã«åã³ã«ã«ã
ãã·ä»¥å€ã®ãã®ã§ãããã®ååç©åã¯ãã®è¬åŠç
ã«èš±å®¹ãããå¡©ã®æ²»ççã«æå¹ãªéã®ååç©ãå«
æããè¬åŠçã«äœ¿çšãåŸãæ äœãå«ãåæ¯ã®æ²»ç
åã³å¶åŸ¡ã®ããã®è¬åŠçµæç©ã ïŒïŒ R4ãäœçŽã¢ã«ã³ãã·ãäœçŽã¢ã«ãã«ããªã
äœçŽã¢ã«ãã«ã¹ã«ããã«ãåã¯ã¢ããã§ããR5
ãæ°ŽçŽ ã§ããå ŽåïŒR4ãæ°ŽçŽ ã§ããR5ãäœçŽã¢
ã«ãã«ã§ããå ŽåïŒåã¯R4åã³R5ãäžç·ã«ãªã€
ãŠã¡ãã¬ã³ã§ããç¹èš±è«æ±ã®ç¯å²ç¬¬ïŒïŒé èšèŒã®
è¬åŠçµæç©ã ïŒïŒ R4ãã¡ããã·ãã¡ãã«ããªãã¡ãã«ã¹ã«
ããã«åã³ã¢ãããããªã矀ããéžæããããã®
ã§ãããR5ãæ°ŽçŽ ã§ããå ŽåïŒR4ãæ°ŽçŽ ã§ãã
R5ãã¡ãã«ã§ããå ŽåïŒåã¯R4åã³R5ãäžç·ã«
çµåããŠã¡ãã¬ã³ã§ããå Žåã§R2åã³R3ãæ°ŽçŽ
ã§ããããããŠR1ãïŒâããã©ãŸãªã«åã³ã«ã«
ããã·ãããªã矀ããéžæããããã®ã§ããç¹èš±
è«æ±ã®ç¯å²ç¬¬ïŒïŒé èšèŒã®è¬åŠçµæç©ã
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP56119373A JPS5821679A (ja) | 1981-07-31 | 1981-07-31 | ãžãã³ããïœïŒïœ ããªãã»ãã³ååç© |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP56119373A JPS5821679A (ja) | 1981-07-31 | 1981-07-31 | ãžãã³ããïœïŒïœ ããªãã»ãã³ååç© |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS5821679A JPS5821679A (ja) | 1983-02-08 |
| JPH0250906B2 true JPH0250906B2 (ja) | 1990-11-05 |
Family
ID=14759897
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP56119373A Granted JPS5821679A (ja) | 1981-07-31 | 1981-07-31 | ãžãã³ããïœïŒïœ ããªãã»ãã³ååç© |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS5821679A (ja) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6310784A (ja) * | 1986-03-03 | 1988-01-18 | Kyowa Hakko Kogyo Co Ltd | æã¢ã¬ã«ã®ãŒå€ |
| EP0436025A4 (en) * | 1988-09-20 | 1991-09-11 | Hisamitsu Pharmaceutical Co. Inc. | Novel dibenz b,e)oxepin derivatives |
| TW209861B (ja) * | 1989-08-25 | 1993-07-21 | Hoechst Roussel Pharma | |
| TW200716588A (en) | 2005-06-02 | 2007-05-01 | Kyowa Hakko Kogyo Kk | A process for preparing dibenzoxepin derivative |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5035180A (ja) * | 1973-07-25 | 1975-04-03 |
-
1981
- 1981-07-31 JP JP56119373A patent/JPS5821679A/ja active Granted
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5035180A (ja) * | 1973-07-25 | 1975-04-03 |
Also Published As
| Publication number | Publication date |
|---|---|
| JPS5821679A (ja) | 1983-02-08 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US4282365A (en) | Dibenz[b,e]oxepin compounds | |
| EP0061800B1 (en) | Anti srs-a carboxylic acid derivatives, processes for their production and pharmaceutical formulations containing them | |
| US4263207A (en) | 10,11-Dihydrodibenzo[b,f][1,4]thiazepine carboxylic acids esters and amides thereof | |
| JPH10504836A (ja) | ãªã«ã眮æè³éŠæãšãŒãã«ååç©åã³é®çã®ããã®è¬å€çµæç©äžãžã®ãããã®äœ¿çš | |
| JPH0469153B2 (ja) | ||
| KR100378892B1 (ko) | ë¥ìœížëŠ¬ì-êžžííì±ìê°ë벀조íŒëì ë첎 | |
| JP2839805B2 (ja) | ãªã°ãã³é¡çžäœåã³ãã®è£œé æ¹æ³ãªãã³ã«æé«èè¡çå€ | |
| JPH07121941B2 (ja) | ãã€ã³ããªãšã³ïœâ²äžïŒâŒæ®æå€ãšããŠã®ãããªãã«âãã³ãŸãããäºç°åŒèªå°äœ | |
| JPH02138259A (ja) | ãžã¢ãªãŒã«ã¹ããªã«ãããªã³ãžã¢ã·ãé¡ | |
| JP2788055B2 (ja) | ã¢ã«ã±ãã³é žèªå°äœããã®è£œé æ¹æ³åã³ãã®äœ¿çš | |
| JPH01301661A (ja) | æ°èŠããªãžã«èªå°äœ | |
| US4582842A (en) | Anti-asthmatic 6H-dibenz-[b,e] [1,4]oxathiepin derivatives, compositions, and method of use therefor | |
| JPH047348B2 (ja) | ||
| JPH0542420B2 (ja) | ||
| JPH029031B2 (ja) | ||
| US4576949A (en) | Use of 5,6,7,8-tetrahydroquinolines and 5,6-dihydropyrindines as leukotriene and lipoxygenase inhibitors and the novel 3-substituted compounds therein | |
| US4394515A (en) | 10,11-Dihydro-11-oxodibenzo[b,f]thiepin compounds | |
| JPH0250906B2 (ja) | ||
| JPS6110554A (ja) | 眮æâïŒâïŒïŒïŒïŒâãžãããâïŒïœâã€ã³ãã³âïŒâã€ã«ïŒâïŒâããããã·âïŒïœâããâã«âïŒïŒïŒâãžãªã³ïŒãã®åæäœåã³å¡© | |
| AU620037B2 (en) | Leukotriene antagonists | |
| JP2001527073A (ja) | âãã§ãã«ã¢ããèªå°äœããã³ïœâããªãžã«ã¢ããèªå°äœã該ååç©ã®è£œé æ¹æ³ãªãã³ã«è©²ååç©ãå«ãå»è¬çµæç© | |
| US4778897A (en) | 6H-dibenz[b,e][1,4]oxathiepin compounds | |
| EP0069810B1 (en) | Novel dibenzoxepins, their preparation, compositions containing them and the use of dibenzoxepins in the treatment of allergic conditions | |
| EP0142754A2 (en) | 2-Substituted-benzoic acid imidazoles, process for preparing them and pharmaceutical compositions containing them | |
| CS241464B2 (cs) | Způsob vÜroby novÜch benzo[cjchinolinů |