JP6184086B2 - Phototherapy device - Google Patents

Description

  The present invention relates to a phototherapy device.

  Photodynamic therapy (hereinafter abbreviated as “PDT”) is a local treatment method that utilizes a photochemical reaction caused by irradiation of a photosensitive substance and a laser beam, which is accumulated in cancer cells.

  In PDT, a photosensitive substance (for example, talaporfin sodium) is administered to a living body, and a cancer cell in which the photosensitive substance is accumulated is irradiated with a laser beam having an excitation wavelength peculiar to the photosensitive substance. This is a treatment method in which singlet oxygen is generated from, and cancer cells are destroyed by this singlet oxygen.

  For example, Patent Literature 1 proposes a phototherapy device that performs PDT.

JP 2006-87646 A

  For example, in cancer treatment, if an untreated part remains after surgery, there is a risk of recurrence, and it may be clinically difficult to perform reoperation. On the other hand, in cancer treatment by PDT, over-irradiation in which laser light is repeatedly applied to the same location many times may not be preferable for the patient.

  However, in PDT, even if a cancer cell in which a photosensitive substance is accumulated is irradiated with a laser beam, the cancer cell itself does not undergo visual degeneration. Among them, there is a problem that it is difficult to determine a treated site and an untreated site irradiated with laser light.

  The present invention is intended to solve the above-described conventional problems, and an object thereof is to provide a phototherapy device that allows an operator to easily grasp a treated site and an untreated site during surgery.

  In order to achieve this object, the phototherapy device of the present invention is a phototherapy device that performs phototherapy using a photosensitizer administered to a living body, and excites the photosensitizer to generate fluorescence. The light of the first output irradiating the observation region and the light having a larger output than the light of the first output excite the photosensitizer to generate singlet oxygen, and the light of the first output emits the light. A light irradiation unit that outputs a second output light that irradiates a treatment site based on fluorescence emitted from a sensitive substance, an imaging unit that images the observation region, and a captured image based on an imaging signal from the imaging unit A captured image generation unit that generates data; a treated image generation unit that generates treated image data indicating a position irradiated with the light of the second output; and the treated image data is superimposed on the captured image data Generate composite image data And the image synthesis and display processing unit, and a display unit that displays the composite image data as a composite image, and a configuration with a.

  According to the phototherapy device of the present invention, the above configuration allows the operator to easily grasp the treated site and the untreated site during the operation. As a result, it is possible to suppress missed laser light irradiation and excessive irradiation on the site to be treated by the surgeon.

1 is a schematic block diagram of a phototherapy device according to Embodiment 1 of the present invention. Diagram showing the relationship between excitation light wavelength and fluorescence wavelength of talaporfin sodium Block diagram of an image processing unit in Embodiment 1 of the present invention The flowchart which shows operation | movement of the observation mode of the phototherapy apparatus in Embodiment 1 of this invention The flowchart which shows operation | movement of the treatment mode of the phototherapy apparatus in Embodiment 1 of this invention. Schematic diagram showing an image displayed on the display unit in the first embodiment of the present invention. Block diagram of an image processing unit in Embodiment 2 of the present invention The flowchart which shows operation | movement of the treatment mode of the phototherapy apparatus in Embodiment 2 of this invention. Schematic diagram showing (a) a second captured image and (b) a second composite image in Embodiment 2 of the present invention.

  Embodiments of the phototherapy device of the present invention will be described below in detail with reference to the drawings. In the following embodiments, talaporfin sodium, which is a chlorin-based photosensitizer, is described as an example of the photosensitizer, but the present invention is not limited to this. Other photosensitizers include porphyrin-based photosensitizers such as photophilin.

(Embodiment 1)
Hereinafter, the phototherapy device according to Embodiment 1 will be described with reference to the drawings.

≪About composition≫
<Overall configuration>
FIG. 1 is a schematic block diagram of a phototherapy device according to Embodiment 1 of the present invention.

  The phototherapy device 1 includes an operation unit 2, a light irradiation unit 3, an imaging unit 4, an image processing unit 5, a display unit 6, and a control unit 7.

<Operation unit 2>
The operation unit 2 is used by an operator such as a doctor to make various settings for the phototherapy device 1. The operation unit 2 sets a mode for identifying a cancer region from the observation region (hereinafter referred to as “observation mode”) and a mode for treating the cancer region identified in the observation mode (hereinafter referred to as “treatment mode”). ) Can be switched by the operator. Further, an ON / OFF switch (not shown) for controlling light irradiation from a light irradiation unit 3 described later is provided. And in the treated image generation part 55 mentioned later, it has the structure in which the setting operation for producing | generating treated image data is possible. The operation unit 2 may have a configuration in which the above-described ON / OFF switch is separately provided as a foot switch.

<Light irradiation part 3>
The light irradiation unit 3 is a light source (hereinafter referred to as “excitation light source”) that can irradiate at least light including a wavelength that can excite the photosensitive substance (hereinafter referred to as “excitation light”). (Not shown). An example of this excitation light source is a semiconductor laser element.
In the case where the photosensitive substance is talaporfin sodium, there are excitation wavelengths having peaks at approximately 405 nm, 510 nm, and 664 nm. The excitation wavelength based on 405 nm has a relatively large peak, but it is not suitable for excitation light because it overlaps with the absorption wavelength of oxyhemoglobin and is difficult to reach deep into living tissue. Moreover, since the excitation wavelength with 510 nm as a reference is a relatively small peak, it is not suitable for excitation light. Therefore, it is desirable to use excitation light with 664 nm as a reference, which has few such problems. In addition, talaporfin sodium has an excitation wavelength in a band of approximately 655 to 670 nm with a peak wavelength of 664 nm as a reference, and has a property of emitting fluorescence having a peak wavelength of approximately 672 nm.

Moreover, the light irradiation part 3 becomes a structure which irradiates the light of a different output by observation mode and treatment mode. In the observation mode, the photosensitive substance is excited and irradiated with relatively weak output light that emits fluorescence (hereinafter referred to as “first output light”). In the treatment mode, the photosensitive substance is excited to emit fluorescence. And a relatively strong output light that generates singlet oxygen from the photosensitive material (hereinafter referred to as “second output light”), that is, the second output light is the first output light. This means that the output is larger than the output light. For example, when the photosensitive substance is talaporfin sodium, the first output light is approximately 125 mW and 10 mW / cm ² output, and the second output light is approximately 265 mW and 150 mW / cm ² output. The light.

  In the observation mode, the light irradiation range (that is, the light output to irradiate the living body with the first output light and the second output light so that the cancer region can be confirmed in a wide observation region at a time (that is, It is desirable that the light irradiation diameter be variable. For example, the first output light is configured to irradiate the observation region with a diameter of about 40 mm, and the second output light is configured to irradiate the observation region with a diameter of about 10 to 15 mm. In this case, an excitation light source for irradiating the first output light and the second output light may be provided separately, or the first output light and the second output light may be provided by one excitation light source. The structure which irradiates may be sufficient. However, when irradiating the first output light and the second output light with one excitation light source, a lens (not shown) that changes the light irradiation diameter between the excitation light source and the observation region is provided manually or automatically. Therefore, it is necessary to make the light irradiation diameter variable between the observation mode and the treatment mode with this lens.

<Imaging unit 4>
The imaging unit 4 images the observation region irradiated by the light irradiation unit 3 in the observation mode. The imaging unit 4 captures an image that cuts the excitation light component and transmits the fluorescent component as much as possible. The signal is output to the image processing unit 5 described later. Specifically, for example, an imaging device such as a CCD or CMOS (not shown) and an excitation light cut filter (notch filter) (not shown) are provided, and this excitation light cut filter is provided between the imaging device and the observation region. Thus, the excitation light component is cut.

  This point will be described with reference to FIG. 2 by taking talaporfin sodium as an example. FIG. 2 shows a spectrum of excitation light (“a” in FIG. 2) irradiated by the light irradiation unit 3 (excitation light source), a spectrum of fluorescence emitted from sodium talaporfin (“b” in FIG. 2), and excitation. It is a figure which shows the transmittance | permeability characteristic ("c" in FIG. 2) of a light cut filter. As shown in FIG. 2, the excitation light cut filter is a filter that can cut the excitation light component and transmit the fluorescence component as much as possible. Therefore, the excitation light cut filter desirably cuts at least the peak wavelength of excitation light among the excitation light components and does not cut the peak wavelength of fluorescence. In the case of talaporfin sodium, a filter capable of cutting light having a wavelength of 655 to 670 nm, which is an excitation light component, is desirable.

<Image processing unit 5>
The image processing unit 5 includes a captured image generation unit 51, a fluorescence intensity calculation unit 52, a determination unit 53, a treatment site image generation unit 54, a treated image generation unit 55, an image composition / display processing unit 56, and a storage unit 57. Based on the imaging signal from the imaging unit 4, processing described later is performed.

<Captured Image Generation Unit 51>
The captured image generation unit 51 generates first captured image data based on the imaging signal captured by the imaging unit 4 in the observation mode. The first captured image data generated here is image data in which the excitation light component is cut by the excitation light cut filter. Then, the first captured image data is output to a fluorescence intensity calculation unit 52, an image composition / display processing unit 56, and a storage unit 57, which will be described later.

<Fluorescence intensity calculation unit 52>
In the observation mode, the fluorescence intensity calculation unit 52 calculates the fluorescence intensity emitted by the photosensitive material based on the first captured image data, and outputs the calculation result to the determination unit 53 described later. Specifically, the fluorescence component for each pixel in the first captured image data is extracted, and the fluorescence intensity of this fluorescence component is calculated. As the calculation of the fluorescence intensity, the intensity of the fluorescence peak wavelength (672 nm for talaporfin sodium) of the photosensitive substance may be used as the fluorescence intensity, or the intensity of a predetermined range of wavelengths based on the fluorescence peak wavelength. May be the fluorescence intensity.

<Determining unit 53>
In the observation mode, the determination unit 53 determines whether each part in the observation region (that is, a position corresponding to each pixel of the first captured image data) is a cancer region based on the calculation result of the fluorescence intensity calculation unit 52. Determine whether or not. Specifically, the determination unit 53 provides a predetermined threshold value for determining whether or not it is a cancer region in advance, and determines whether or not the fluorescence intensity of each part in the observation region is greater than the predetermined threshold value. In other words, a high fluorescence intensity indicates that a large amount of photosensitive substance is accumulated, and it is possible to determine such a site as a cancer region. Then, the pixel portion determined to be larger than the predetermined threshold is determined as a cancer region, and information related to the position of the pixel in the first captured image data is output to the treatment site image generation unit 54 described later.

<Treatment site image generation unit 54>
In the observation mode, the treatment site image generation unit 54 generates treatment site image data based on the information regarding the pixel position output from the determination unit 53, and the first captured image data is combined with and displayed in an image, which will be described later. The data is output to the processing unit 56. The treatment site image data is an image indicating the position of the cancer cell in the observation region of the first captured image data.

<Treated image generator 55>
The treated image generation unit 55 generates treated image data indicating the position and range of a part irradiated with light of the second output in the observation region (that is, a treated part) in the treatment mode. And output to the display processing unit 56. This treated image data is performed under the command of the control unit 7 described later through the operation of the operation unit 2. Specifically, the operator operates the operation unit 2 while confirming a first composite image, which will be described later, displayed on the display unit 6, and determines the position of the treated site irradiated with laser light in the first composite image. Based on the specified position information, treated image data is generated. Then, the treated image data is output to an image composition / display processing unit 56 described later.

<Image Composition / Display Processing Unit 56>
In the observation mode, the image composition / display processing unit 56 takes out the first captured image data output from the captured image generation unit 51 from the storage unit 57, and outputs the captured image data and the treatment site image generation unit 54. The treatment site image data is synthesized and first synthesized image data is generated. The first composite image data is an image in which the treatment site image is displayed superimposed on the captured image. Then, the image composition / display processing unit 56 outputs the first composite image data to the display unit 6 and the storage unit 57. A first composite image is displayed on the display screen of the display unit 6.

  On the other hand, in the treatment mode, the image composition / display processing unit 56 extracts the first composite image data from the storage unit 57, and synthesizes the treated image data and the first composite image data from the treated image generation unit 55. Then, the second composite image data is generated. The second composite image data is an image in which the treated image is displayed superimposed on the first composite image. Then, the second composite image data is output to the display unit 6, and the second composite image is displayed on the display screen of the display unit 6.

<Storage unit 57>
The storage unit 57 stores the first captured image data from the captured image generation unit 51 and the first composite image data from the display processing unit 56, and outputs the stored data to the display processing unit 56.

<Control unit 7>
The control unit 7 controls each block (mainly the light irradiation unit 3, the imaging unit 4, and the image processing unit 5) in the phototherapy device 1 under the instruction of the operation unit 2.

≪About operation≫
The operation of the phototherapy device 1 having the above configuration will be described using the flowcharts of FIGS. 4 and 5 in consideration of the operation of the operator. 4 shows a flowchart in the observation mode, and FIG. 5 shows a flowchart in the treatment mode.

≪About operation in observation mode≫
Hereinafter, operation | movement of the phototherapy apparatus 1 in observation mode is demonstrated using FIG.

<Step 1 (S001)>
In step 1 (S001), the light irradiation unit 3 is set toward the observation region where the operator performs treatment, and the operation unit 2 is set to the observation mode by operation. At this time, the ON / OFF switch of the operation unit 2 is in an OFF state. At this time, the patient to be treated is in a state where a photosensitive substance is administered.

<Step 2 (S002)>
In Step 2 (S002), when the operator turns on the ON / OFF switch of the operation unit 2, the first output light in the observation mode is emitted from the excitation light source of the light irradiation unit 3 toward the observation region. The At this time, in the observation mode, it is assumed that the first output light applied to the observation region is set to have a light irradiation diameter of 40 mm. The light of the first output excites the photosensitive substance existing in the observation region and emits fluorescence.

<Step 3 (S003)>
In step 3 (S003), the imaging unit 4 images the observation region irradiated with the first output light, the captured image generation unit 51 constructs the first captured image data, and the image composition / display processing unit The first captured image data is displayed on the display unit 6 through the process 56. At this time, as described above, the imaging signal captured by the imaging unit 4 is an imaging signal in which the excitation light component is cut by the excitation light cut filter. Then, a display screen 101 as shown in FIG. 6A is displayed on the display unit 6. That is, in the observation region 102 in FIG. 6A, the cancer cell (cancer region 103) in which a large amount of the photosensitive substance is accumulated emits fluorescence with stronger intensity than the normal cell (normal region 104). The displayed image is displayed on the display unit 6. However, in this case, in particular, the boundary between the normal region and the cancer region may be difficult to understand, or the normal region and the cancer region may be difficult to discriminate. Therefore, the process proceeds to Step 4 (S004) described later.

<Step 4 (S004)>
In step 4 (S004), the fluorescence intensity calculation unit 52 calculates the fluorescence intensity of each pixel in the first captured image data based on the first captured image data generated by the captured image generation unit 51.

<Step 5 (S005)>
In step 5 (S005), the determination unit 53 has a predetermined threshold value in advance, and compares the fluorescence intensity of each pixel in the first captured image data calculated by the fluorescence intensity calculation unit 52 with the predetermined threshold value. When a pixel having a predetermined threshold value or more exists in the observation region (“YES” in FIG. 4), the pixel is determined to be a cancer region, and the position of the pixel in the first captured image data is determined as the treatment site image. The data is output to the generation unit 54. On the other hand, if there is no pixel equal to or greater than the predetermined threshold in the observation area (“NO” in FIG. 4), the process returns to step 1 (S001), and the same steps are repeated again in another observation area. It will be.

<Step 6 (S006)>
In step 6 (S006), the treatment site image generation unit 54 generates treatment site image data for the pixels determined by the determination unit 53 to be equal to or greater than the threshold value. The treatment site image data is, for example, an image (for example, color identification) that allows an operator to identify a pixel determined to be equal to or greater than a threshold from the first captured image data as a cancer region.

<Step 7 (S007)>
In step 7 (S007), the image composition / display processing unit 56 synthesizes the first captured image data and the treatment site image data to generate first composite image data, and displays the first composite image data. Output to unit 6. In this case, as shown in FIG. 6B, an image in which the treatment site image 105 is superimposed on the captured image is displayed on the display screen 101 as the first composite image. Then, the operator confirms this image and shifts to the treatment mode.

≪Treatment mode operation≫
Hereinafter, the operation of the phototherapy device 1 in the treatment mode will be described with reference to FIG. This treatment mode operation is an operation performed after the observation mode processing is completed.

<Step 1 (S021)>
In step 1 (S021), the treatment mode is set by operating the operation unit 2 by the operator so as to irradiate the cancer region observed in the observation mode with laser light. At this time, the ON / OFF switch of the operation unit 2 is in an OFF state. In addition, the display unit 6 is in a state where the first composite image generated in the observation mode is displayed.

<Step 2 (S022)>
In step 2 (S022), the light irradiation unit 3 sets the light irradiation unit 3 at a position where the light irradiation unit 3 should irradiate the second output light to the observation region while the operator confirms the first composite image on the display unit 6. Then, the ON / OFF switch of the operation unit 2 is turned ON. By turning on the ON / OFF switch of the operation unit 2, the second output is performed for the cancer region in the observation region observed in the observation mode (that is, the region of the treatment site image displayed in the first composite image). Will be irradiated. At this time, in the treatment mode, it is assumed that the second output light applied to the cancer region is set to have a light irradiation diameter of 10 mm. This second output light is larger than the first output light. By continuing to irradiate this light for a predetermined time, the photosensitive substance is excited to emit fluorescence, and singlet oxygen is emitted. This singlet oxygen can be generated and cancer cells can be destroyed.

<Step 3 (S023)>
In step 3 (S023), the operator operates the operation unit 2 sequentially, so that the second time period of the cancer region in the observation region (that is, the region of the treatment site image of the first composite image) for a predetermined time. The treated part is identified by irradiating the output light.

<Step 4 (S024)>
In Step 4 (S024), based on the operation of the operation unit 2 in Step 3 (S023), the control unit 7 instructs the treated image generation unit 55 to generate treated image data. Specifically, the treated image generation unit 55 generates treated image data based on information on a site that has been treated in the cancer region of the first composite image by the operation of the operation unit 2.

<Step 5 (S025)>
In step 5 (S025), the image composition / display processing unit 56 synthesizes the first composite image data and the treated image data to generate second composite image data, and displays the second composite image data. Output to unit 6. For example, in the middle of treatment, as shown in FIG. 6C, a circular treated image 106 is superimposed on the first synthesized image at the treated site in the first synthesized image instructed by the operator. Will be displayed. Further, when the treatment is completed for all the cancer regions 103 in the observation region, for example, as shown in FIG. 6D, the treated image 106 is displayed superimposed on all the regions of the cancer region 103. Will be.

<Step 6 (S026)>
In step 6 (S026), when the treated image 106 is displayed superimposed on all the cancer regions 103 as shown in FIG. 6D of step 5 (S025), the treatment is completed. ("YES" in FIG. 5) On the other hand, if the treated image 106 is not displayed superimposed on all the cancer areas 103 as shown in FIG. 6C, the process returns to step 2 (S022), The same steps are repeated again in the untreated region.

<< Summary of Embodiment 1 >>
In Embodiment 1 described above, the operator can appropriately mark the treated part on the display screen displayed on the display unit as a treated image. Since the site and the untreated site can be easily grasped, it is possible to suppress the laser beam irradiation overshoot and over-irradiation on the site to be treated by the surgeon.

(Embodiment 2)
The phototherapy device shown in Embodiment 1 is shown in the configuration in which the treated image is displayed superimposed on the first composite image when the operator operates the operation unit.

  In the phototherapy device shown in the second embodiment, even if the surgeon is in operation, the treatment site and the non-treatment site can be easily grasped, and the surgeon can miss the laser beam irradiation on the site to be treated. A configuration that can be further suppressed will be described. That is, the phototherapy device in the second embodiment shows a configuration in which the operator himself / herself automatically displays the treated image superimposed on the first composite image without operating the operation unit. Note that the description of the same configuration as that of Embodiment 1 is omitted.

  Hereinafter, the phototherapy device according to Embodiment 2 will be described with reference to the drawings.

≪About composition≫
<Overall configuration>
The schematic block diagram of the phototherapy device in the second embodiment is the same as FIG. 1 shown in the first embodiment. The description of the same configuration as that in Embodiment 1 is omitted.

<Light irradiation part 3>
The light irradiation unit 3 is different from the first embodiment in that a guide light source (not shown) for irradiating guide light is provided separately from the excitation light source. The guide light source is configured so that at least the center position of the light irradiated by the excitation light source with the second output light and the center position of the light irradiated with the guide light emitted by the guide light source substantially coincide in the treatment mode. ing. This guide light source is, for example, light that can output light having a light irradiation diameter of 1 to 2 mm. The guide light source is light that can be recognized by the imaging unit 4 at the position where the guide light is irradiated to the observation region, and is light that emits light in a visible light band such as a blue light source or a red light source.

In the treatment mode, when the operator turns on the ON / OFF switch of the operation unit 2 in the treatment mode, this guide light source is applied to a portion that irradiates the second output light for a certain period of time before irradiating the second output light. Irradiates guide light. Then, after a certain time has elapsed, the irradiation of the guide light is stopped, and the cancer cells are treated by irradiating the second output light.
<Imaging unit 4>
The imaging unit 4 has the same function in the observation mode as in the first embodiment.

  In the treatment mode, when the guide light is irradiated from the guide light source of the light irradiation unit 3, the observation region including the portion irradiated with the guide light is imaged, and the imaging signal is output to the image processing unit 5.

<Image processing unit 5>
The image processing unit 5 includes a captured image generation unit 51, a fluorescence intensity calculation unit 52, a determination unit 53, a treatment site image generation unit 54, a treated image generation unit 55, an image composition / display processing unit 56, and the same as in the first embodiment. In addition to the storage unit 57, a guide light irradiation position specifying unit 58 is included.

  The configurations of the fluorescence intensity calculation unit 52, the determination unit 53, and the treatment site image generation unit 54, the captured image generation unit 51 related to the observation mode, the image composition / display processing unit 56, and the storage unit 57 are the same as those in the first embodiment. Therefore, explanation is omitted.

<Captured Image Generation Unit 51>
The captured image generation unit 51 has the same function in the observation mode as in the first embodiment.

  In the treatment mode, second captured image data is generated based on an imaging signal obtained by imaging the observation region irradiated with the guide light, and the second captured image data is output to the guide light irradiation position specifying unit 58.

<Guide light irradiation position specifying unit 58>
The guide light irradiation position specifying unit 58 analyzes the second captured image data from the captured image generating unit 51 and specifies the position where the guide light is irradiated in the observation region. Specifically, a guide light component for each pixel in the second captured image data is extracted, and in the second captured image data, the position of the extracted pixel (that is, the position irradiated with the guide light in the observation region). ). Then, information related to the specified pixel position is output to the treatment image generation unit 55.

<Treated image generator 55>
The treated image generation unit 55 generates treated image data based on the position irradiated with the guide light in the observation area of the second captured image data specified by the guide light irradiation position specifying unit 58, and combines and displays the image. The data is output to the processing unit 56.

<Image Composition / Display Processing Unit 56>
The image composition / display processing unit 56 has the same function in the observation mode as in the first embodiment.

  In the treatment mode, the first combined image data stored in the storage unit 57 and the treated image data generated by the treated image generation unit 55 are combined to generate second combined image data. Then, the second composite image data is output to the display unit 6, and the second composite image is displayed on the display screen of the display unit 6.

≪About operation≫
The operation of the phototherapy device 1 having the above configuration will be described with reference to FIG. In addition, since the operation | movement of the phototherapy apparatus 1 in observation mode is the same as that of Embodiment 1, description is abbreviate | omitted. Here, the operation of the phototherapy device 1 in the treatment mode will be described.

<Step 1 (S101)>
In step 1 (S101), the treatment mode is set by the operator operating the operation unit 2 so as to irradiate the cancer region observed in the observation mode with laser light. At this time, the ON / OFF switch of the operation unit 2 is in an OFF state.

<Step 2 (S102)>
In step 2 (S102), the operator confirms the first composite image (for example, FIG. 6B) on the display unit 6 while light is emitted to the position where the second output light should be irradiated in the observation region. Set the irradiation unit 3 and turn on the ON / OFF switch of the operation unit 2. Thereby, the guide light is irradiated from the guide light source of the light irradiation unit 3 to the position where the second output light is to be irradiated for a certain period of time.

<Step 3 (S103)>
In step 3 (S103), along with the irradiation of the guide light, the captured image generation unit 51 captures an observation area including a portion irradiated with the guide light, and generates second captured image data. In this case, for example, as shown in FIG. 9A, an image of the observation region irradiated with guide light (guide light irradiation position 107 shown in FIG. 9A) is obtained as the second captured image. Become.

<Step 4 (S104)>
In step 4 (S104), the light irradiation unit 3 stops the guide light irradiation after a predetermined time for irradiating the guide light with the ON / OFF switch of the operation unit 2 being turned on, and the light of the second output To destroy cancer cells.

<Step 5 (S105)>
In step 5 (S105), the guide light irradiation position specifying unit 58 specifies the position of the observation region irradiated with the guide light in the second captured image data imaged in step 3 (103). That is, the pixel at each position of the second captured image data is analyzed, and for example, the guide light irradiation position 107 in the second captured image data illustrated in FIG. 9A is specified.

<Step 6 (S106)>
In step 6 (S106), the treated image generation unit 55 generates treated image data based on the position irradiated with the guide light in step 5 (S105).

<Step 7 (S107)>
In step 7 (S107), the image composition / display processing unit 56 synthesizes the first composite image data and the treated image data to generate second composite image data, and displays the second composite image data Output to unit 6. In this case, for example, as illustrated in FIG. 9B, the second composite image is an image in which the center position of the treated image 106 substantially matches the center position of the guide light irradiation position 107.

<Step 8 (S108)>
In step 8 (S108), when the treated images 106 are superimposed on all the cancer areas as shown in FIG. 6D of step 5 (S025) shown in the first embodiment, treatment is performed. Is completed ("YES" in FIG. 5). On the other hand, if the treated images 106 are not superimposed and displayed on all the cancer areas as shown in FIG. Returning to (S102), the same steps are repeated again in the untreated region.

<< Summary of Embodiment 2 >>
In Embodiment 2 shown above, since the operator can automatically mark the treated region on the display screen displayed on the display unit as a treated image as appropriate, even during surgery, The treated and untreated areas can be easily grasped, and the surgeon will not forget to mark the treated images, and the laser beam irradiation and over-irradiation on the area to be treated will be further suppressed. Is possible.

  The present invention is configured as described above, and according to the phototherapy device of the present invention, the above configuration allows the operator to easily grasp the treated and untreated sites during the operation. It is possible to suppress the loss of laser beam irradiation to the site to be treated.

DESCRIPTION OF SYMBOLS 1 Phototherapy apparatus 2 Operation part 3 Light irradiation part 4 Imaging part 5 Image processing part 5
6 Display unit 7 Control unit 51 Captured image generation unit 52 Fluorescence intensity calculation unit 53 Determination unit 54 Treatment site image generation unit 55 Treated image generation unit 56 Image composition / display processing unit 57 Storage unit 57
58 Guide light irradiation position specifying unit 101 Display screen 102 Observation region 103 Cancer region 104 Normal region 105 Treatment site image 106 Treated image 107 Guide light irradiation position

Claims (6)

A phototherapy device that performs phototherapy using a photosensitive substance administered to a living body,
Exciting the photosensitive material to generate fluorescence, and the first output light to irradiate the observation region and the output having a larger output than the first output light excite the photosensitive material to generate singlet oxygen. The second output light irradiating the treatment site based on the fluorescence emitted from the photosensitive substance by the first output light and the center of the position where the second output light is irradiated are substantially the same. A light irradiation unit that emits guide light that is irradiated at a center position of the second output light and irradiates the second output light for a certain period of time before irradiation with the second output light ;
An imaging region that images the observation region irradiated with the first output light, and the observation region irradiated with the guide light ;
Generating a first captured image data on the basis of the image signal of the observation area irradiated with the first light output from the imaging unit, the second captured image based on the image signal of the observation area irradiated with the guide light A captured image generation unit for generating data ;
A fluorescence intensity calculator for calculating fluorescence intensity at each position of the first captured image data;
A determination unit that has a predetermined threshold in advance and determines a position indicating a fluorescence intensity equal to or greater than the predetermined threshold among the fluorescence intensities at each position of the first captured image data as a treatment site;
A treatment site image generation unit that generates treatment site image data based on the position determined as the treatment site by the determination unit;
A treated image generation unit that generates treated image data indicating a position where the light of the second output is irradiated based on the second captured image data;
First composite image data in which the treatment site image data is superimposed on the first captured image data, and second composite image data in which the treatment image data is superimposed on the first composite image data are generated. An image composition / display processing unit;
A display unit for displaying the first composite image data as a first composite image, and displaying the second composite image data as a second composite image;
A phototherapy device comprising:   The phototherapy apparatus according to claim 1, further comprising an operation unit capable of performing a setting operation for generating and displaying the treated image data in the first composite image data with respect to the treated image generation unit. The phototherapy device according to claim 1 , wherein the guide light of the light irradiation unit is light in a visible light band. In each position of the second captured image data, a guide light irradiation position specifying unit that specifies a position irradiated with the guide light is provided, and the treated image generation unit is a position irradiated with the specified guide light The phototherapy device according to any one of claims 1 to 3 , wherein the treated image data is generated based on the method. The light irradiation unit, the light irradiation diameter of the first output light, and configured to be larger than the light irradiation diameter of the second output light, according to any one of claims 1 to 4 Light therapy device. The imaging unit includes an imaging element and an excitation light cut filter positioned between the imaging element and the observation region, and the excitation light cut filter cuts a peak wavelength of excitation light of the photosensitive substance. And the phototherapy apparatus as described in any one of Claim 1 to 5 comprised from the excitation light cut filter which does not cut the peak wavelength of fluorescence.