JP5067529B2 - Oral composition - Google Patents

Description

  The present invention relates to a composition for oral cavity that does not get tired even if it is continuously used, and further increases the intention to use it continuously.

  Conventionally, oral care such as toothpaste and mouthwash is used to remove plaque that causes caries or periodontal disease and to clean the oral cavity. However, although oral care is meaningful only if it continues and becomes a habit, continuation of oral care may get bored with the oral composition to be used, and the continuation of oral care may be interrupted.

  From the above, regardless of the initial use feeling of the oral composition, even if it is used continuously for a certain period of time, it will not get bored with the oral composition, and the intention to use it will continue to increase, and it will be used for a long time There was a need for something that could continue. In addition, the following is mentioned as a prior art document relevant to this invention.

JP-A-7-268851 JP 2000-26260 A JP 2001-19992 A JP 2004-357596 A Noriyuki Yoshida, Evaluation of Psychophysiological Action and Usefulness of Scent, “AROMA RESEARCH”, 2001, No. 1, p38-43

  The present invention has been made in view of the above circumstances, and does not get tired even if it is used continuously for a certain period of time, and further increases the intention to use it continuously. The purpose is to provide.

  As a result of intensive studies to achieve the above object, the present inventor has found that cassia oil, chamomile oil, nutmeg oil, ginger oil, wintergreen oil, clove oil, and eucalyptus oil have some effect on both the electroencephalogram and the autonomic nerve. And found that there is a psychophysiological effect. Furthermore, the specific component which gives such (A) psychological effect, (B) the specific component which gives irritation | stimulation, and the specific component which has (C) bitterness respectively mix | blends specific amount, and from a flavor side By making improvements, we know that we will not get bored even if it is used continuously for a certain period of time, and that we intend to use it further (hereinafter sometimes abbreviated as “high intention to use continuously”), and make the present invention. It has come.

Accordingly, the present invention provides the following inventions.
The combination of the components (A) to (C) in the following 1), wherein the component (A) is 0.0001 to 3% by mass in the composition, and the component (B) is 0.0005 to 1% by mass in the composition. And (C) component for oral cavity containing 0.001-3 mass% in a composition.
1)
(A) One or more selected from cassia oil, chamomile oil and nutmeg oil (B) capsicum oleoresin (C) gentian extract

  According to the composition for oral cavity of the present invention, even if it is continuously used for a certain period of time, it does not get tired, and further, the intention to use it continuously can be increased, and oral care can be continued to make it easy to become a habit.

  The composition for oral cavity of this invention contains 0.0001-3 mass% of the following (A) component, 0.005-1 mass% of (B) component, and 0.001-3 mass% of (C) component. It is a composition for oral cavity.

  The component (A) is one or more selected from cassia oil, chamomile oil, nutmeg oil, ginger oil, winter green oil, clove oil, and eucalyptus oil. These components affect any of electroencephalograms (pleasant / unpleasant, sedation / excitement) and autonomic nerves (relaxing / active / exciting / disgusting feeling) and are psychophysiological influencing agents. The measuring method will be described in detail in a test example described later. In the present invention, among the component (A), cassia oil, chamomile oil, and nutmeg oil are particularly preferable.

  (A) The compounding quantity of a component is 0.0001-3 mass% in an oral cavity composition, Preferably it is 0001-0.3 mass%. When the blending amount of the component (A) is outside the range of 0.0001 to 3% by mass, it is not possible to show a high intention to use continuously.

  Component (B) is one or more selected from capsicum oleoresin, capsaicin, dihydrocapsaicin, nordihydrocapsaicin, piperine, sanshool, mountain pepper, diallyl disulfide, allyl isothiocyanate, and mustard. Yes, it is a component that mainly stimulates. In the present invention, capsicum oleoresin is particularly preferable among the components (B).

  (B) The compounding quantity of a component is 0.0005-1 mass% in an oral composition, Preferably it is 0.001-0.5 mass%. When the blending amount of the component (B) is out of the range of 0.0005 to 1% by mass, it is not possible to show a high intention to continue use.

(C) Pheasant extract, Clara extract, Chinpi extract, Hop extract, Jujuy extract, Arnica extract, Ryokucha extract, Gentian extract, Grapefruit oil, tranexamic acid, cetylpyridinium chloride, chlorhexidine hydrochloride, gluconic acid It is one or more selected from chlorhexidine, triclosan, isopropylmethylphenol, caffeine, phenoxyethanol, and dodecyldiaminoethylglycine, and is a component mainly having a bitter taste. In the present invention, (C) one or two selected from a pheasant extract, a clara extract, a chimpan extract, a hop extract, a juicy extract, an arnica extract, a ryokcha extract, a gentian extract and a grapefruit oil The gentian extract is particularly preferable.

  Among the components (C), a pheasant extract, a clara extract, a chimpan extract, a hop extract, a juicy extract, an arnica extract, a ryokcha extract, and a gentian extract can be obtained by a commercially available product or a known extraction method. Can be used.

  Pheasant is a herbal medicine consisting of immature fruits of candied daidai, natsudaidai and other related plants. Clara (scientific name: Sophora flavescens Ait) is a perennial of the legume family. Chimpi is a herbal medicine made of mature pericarp of Citrus unshiu. Hop is famous as a raw material for beer and is a plant of the family Asapaceae. Zyuyaku (ten drugs) is a herbal medicine consisting of the above-ground part of the flowering stage of Houttuynia cordata Thunberg of the Sauraceae family. Arnica is a kind of herb extracted from the flower of Arnica plant Arnica. Ryokucha (green tea) is a non-fermented tea made by steaming tea leaves to evaporate moisture and drying them. Gentiana (scientific name Gentiana lutea L.) belongs to the Gentianaceae family, and is a herbal medicine that is used after some fermentation of the roots and rhizomes and drying.

  Examples of the solvent used in the extraction method include water; alcohols such as methanol, ethanol, propanol, and butanol; polyhydric alcohols such as propylene glycol and butylene glycol, and the like. These may be used alone or in combination of two or more. Can be used as

  Various conditions in the extraction method are not particularly limited, but the ratio of the extraction raw material to the extraction solvent is usually in a range of about 1: 2 to 1:50 extraction raw material: extraction solvent = 1: 50 by mass ratio. preferable. The extraction temperature is preferably in the range of 5 to 80 ° C., and is preferably performed by immersing or stirring in the extraction solvent for 1 hour to 1 week. The extraction pH is not particularly limited as long as it is not extremely acidic or alkaline.

  When the extraction solvent is a non-toxic solvent such as water, ethanol, water / ethanol (hydrous ethanol), the extract may be used as it is or as a diluent. Moreover, the said extract may be used as a concentrated extract, and may be made into a dry powder by freeze drying or the like, or may be prepared in a paste form. When other solvents are used, it is preferable to distill the solvent and dilute the dried portion with a non-toxic solvent.

  (C) The compounding quantity of a component is 0.001-3 mass% in an oral cavity composition, Preferably it is 0.01-1.5 mass%. When the blending amount of the component (B) is outside the range of 0.001 to 3% by mass, it is not possible to indicate a high continuous use intention.

  In addition to the components (A) to (C), an optional component that can be used for the oral composition can be added to the oral composition of the present invention. Specific examples of moisturizing agents include polyhydric alcohols such as glycerin, sorbit, propylene glycol, and polyethylene glycol, surfactants such as anionic surfactants such as sodium lauryl sulfate, decaglyceryl laurate, polyoxyethylene hydrogenated castor oil, and myristic acid. Nonionic surfactants such as diethanolamide, fluorides such as sodium fluoride as active ingredients, enzymes such as dextranase and mutanase, tranexamic acid, ε-aminocaproic acid, etc., saccharin sodium, menthol, peppermint, spearmint as flavoring agents Etc. In addition, the compounding quantity of these arbitrary components can be made into an effective quantity in the range which does not prevent the effect of this invention.

  The oral composition of the present invention can be obtained by a conventional method by mixing the above-mentioned essential components, optional components, and water (the remainder blended so that the oral composition is 100% by mass).

  The composition for oral cavity of this invention can be used as a toothpaste and a mouthwash, and is suitable as a mouthwash. The dosage form can be prepared as a liquid, ointment, paste, gel, sol, cream, etc., but liquid is preferred.

  The composition for oral cavity of the present invention does not get tired even if it is continuously used for a certain period (about 14 days or more), further increases the intention to use it continuously, makes it possible to continue oral care and make it easy to become a habit.

  EXAMPLES Hereinafter, although an Example and a comparative example are shown and this invention is demonstrated concretely, this invention is not restrict | limited to the following Example. In the following examples, unless otherwise specified, “%” in the composition represents mass%.

[Test example]
For chamomile oil, cassia oil, eucalyptus oil, winter green oil, nutmeg oil, clove oil, ginger oil, thyme white oil, and perilla oil, a mouthwash was prepared by the following method, and 8 subjects used this mouthwash. The psychophysiological effects were evaluated based on the following method. The results are shown in Table 4.

Preparation of mouthwash Chamomile oil, cassia oil, winter green oil, eucalyptus oil, nutmeg oil, clove oil, ginger oil, thyme white oil and perilla oil alone, 0.1 parts each, the following mouthwash base It was added to 99.9 parts and dissolved by stirring to obtain a mouthwash.
Mouthwash base composition (%)
Citric acid 0.03
Sodium citrate 0.25
Sodium benzoate 0.30
Sorbitol 0.70
Glycerin 1.00
Propylene glycol 0.50
Methylparaben 0.10
HCO 60 1.00
(Polyoxyethylene hydrogenated castor oil)
Purified water 96.02
Total 99.9

(1) Brain wave measurement The brain wave measurement for 102.4 seconds was performed 5 times continuously. During the second measurement time, the eyes were opened, and 20 mL of mouthwash was contained in the mouth for 20 seconds, and then discharged. Except when this mouthwash was used, the eyes were rested and closed. The first measurement before using the mouthwash was made before using the mouthwash, the second measurement was made while using the mouthwash, and the third to fifth measurements were made after using the mouthwash.
).

The subject's brain waves were measured using a simple α-wave frequency rhythm measuring machine (manufactured by Human Sensing Co., Ltd.). For measurement, electrodes were attached to two frontal regions of Fp1 and Fp2 according to the International 10-20 method, and frontal brain waves (8 to 13 Hz) were recorded using the right earlobe as the ground and the left earlobe as the reference electrode. The left and right frequencies and temporal variations (fluctuations) of the recorded brain waves were analyzed, and Professor Yoshida's theory (reference: Yoshiyuki Yoshida, “Evaluation of psychophysiological effects and usefulness of fragrances”, AROMA RESEARCH No. 1, 38-43 (2001)), the physiological state and the psychological state were confirmed. That is, the physiological state of brain activity (frequency increase → transition to arousal state, frequency decrease → transition to sleep state) is obtained from the frequency of the left and right brain waves, and the left rhythm degree from the fluctuations of the left and right brain waves; The degree of right rhythm; sedation-excited psychological degree in two axes and the overall psychological state.
The evaluation was performed using a blank before using the mouthwash, and the effect was judged from changes in brain activity and psychological state "from use to use" compared to before use.

About brain activity,
[Average value of activity after use-activity before use-activity before use]> The number of subjects who became 0 was used as an index and evaluated based on the following criteria.

About the psychological state, it judged comprehensively from the following right-and-left rhythm degree.

(2) Electrocardiogram measurement After apparatus idling for 3 minutes, the measurement was continuously performed for 6 minutes and 50 seconds in accordance with the time for the above (1) brain wave measurement. The timing before, during and after use of the mouthwash was based on electroencephalogram measurement, and the data of each section were analyzed independently after the measurement.

The electrocardiogram of the subject was measured using a circulatory dynamic waveform / fluctuation analysis software Fraclet WT (Dainippon Pharmaceutical Co., Ltd.). The measurement was performed with a negative electrode on the upper right chest, a positive electrode on the lower left chest, and a ground electrode on the upper left chest so that the heart is sandwiched diagonally. Heart rate fluctuations were analyzed based on the ECG signal waveform to determine the activity of autonomic nerves (sympathetic and parasympathetic).
In the evaluation, the mouthwash before use was blank, and the effect was judged from the change in autonomic nerve activity from “in use to after use” with respect to before use.

  That is, evaluation was performed based on the following criteria, using as an index the number of subjects whose [symmetry nerve or parasympathetic nerve activity [average value after use to after use] − (average value before use]> 0). In addition, the balance of the autonomic nervous system was judged from the activity of the sympathetic nerve and the parasympathetic nerve, and was also written as the autonomic nervous system analysis result (balance).

  Chamomile oil, cassia oil, eucalyptus oil, winter green oil, nutmeg oil, clove oil, and ginger oil affected both the electroencephalogram and autonomic nerve, and had psychophysiological influence.

[Examples 1 to 18, Reference Examples 1 to 8, Comparative Examples 1 to 17]
Mouthwashes having the compositions shown in Tables 5 to 12 were prepared, and the intention to use was evaluated by the following methods. The results are also shown in the table.

<Intended use evaluation method>
Whether or not you want to continue using mouthwashes for 33 subjects each time, twice a day, 10 mL each time for 2 weeks, 2 times after the first use and 2 weeks later (when finished) The following criteria were used for evaluation. A result is shown by the average value of 33 persons.
Judgment Criteria for Use Intention 7; Very Wanted 6; Pretty Wanted 5; Somewhat Wanted 5; Somewhat Wanted 4; Neither Wanted 3; Somewhat Not Wanted 2; Somewhat Not Wanted 1;

From the following formula, the change in intention to use (%) by continuous use of each sample was determined.
Rate of change in intention to use due to continuous use (%)
= [(Average value of intention to use after 2 weeks of continuous use)-(Average value of intention to use for the first time)] /
(Average value of initial intention to use) x 100

  According to the above results, the composition for oral cavity of the present invention had a high “intention to use” after continuous use for 2 weeks, a high change in the intent to use, and the preference increased with continuous use.

Claims (11)

The combination of the components (A) to (C) in the following 1), wherein the component (A) is 0.0001 to 3% by mass in the composition, and the component (B) is 0.0005 to 1% by mass in the composition. And (C) component for oral cavity containing 0.001-3 mass% in a composition.
1)
(A) One or more selected from cassia oil, chamomile oil and nutmeg oil (B) capsicum oleoresin (C) gentian extract The combination of the components (A) to (C) in the following 2), wherein the component (A) is 0.0001 to 3% by mass in the composition, and the component (B) is 0.0005 to 1% by mass in the composition. And (C) component for oral cavity containing 0.001-3 mass% in a composition.
2)
(A) 1 type, or 2 or more types chosen from cassia oil, nutmeg oil, and ginger oil (B) allyl isothiocyanate (C) 1 type, or 2 or more types chosen from a jujube extract. The combination of the components (A) to (C) selected from the following 3) to 5), wherein the component (A) is 0.0001 to 3% by mass in the composition, and the component (B) is 0.00 in the composition. The composition for oral cavity containing 0005-1 mass% and 0.001-3 mass% in (C) component in a composition.
3)
(A) One or more selected from cassia oil and chamomile oil (B) One or more selected from dihydrocapsaicin and mustard (C) Ryokucha extract 4)
(A) One or more selected from cassia oil and chamomile oil (B) One or more selected from allyl isothiocyanate and mustard (C) Gentian extract 5)
(A) One or more kinds selected from cassia oil and chamomile oil (B) One or more kinds selected from nordihydrocapsaicin, mountain pepper and sanshool (C) Chinpi extract The combination of the components (A) to (C) in the following 6), wherein the component (A) is 0.0001 to 3% by mass in the composition, and the component (B) is 0.0005 to 1% by mass in the composition. And (C) component for oral cavity containing 0.001-3 mass% in a composition.
6)
(A) One or more selected from nutmeg oil and ginger oil (B) One or more selected from capsicum oleoresin and dihydrocapsaicin (C) Selected from juyaku extract and arnica extract 1 type or 2 types or more The combination of the components (A) to (C) of the following 7), wherein the component (A) is 0.0001 to 3% by mass in the composition, and the component (B) is 0.0005 to 1% by mass in the composition. And (C) component for oral cavity containing 0.001-3 mass% in a composition.
7)
(A) Cassia oil (B) One or more selected from capsaicin, mountain pepper and mustard (C) One or more selected from Clara extract, Chinpi extract and Gentian extract The combination of the components (A) to (C) of the following 8) or 9), wherein the component (A) is 0.0001 to 3% by mass in the composition, and the component (B) is 0.0005 to 0.0005 in the composition. The composition for oral cavity containing 1 mass% and 0.001-3 mass% in (C) component in a composition.
8)
(A) Nutmeg oil (B) Allyl isothiocyanate (C) Grapefruit oil 9)
(A) Nutmeg oil (B) One or more selected from capsicum oleoresin and mustard (C) One or more selected from Clara extract and grapefruit oil The combination of the components (A) to (C) of 10) below, wherein the component (A) is 0.0001 to 3% by mass in the composition, and the component (B) is 0.0005 to 1% by mass in the composition. And (C) component for oral cavity containing 0.001-3 mass% in a composition.
10)
(A) Chamomile oil (B) Mountain pepper (C) Clara extract 11) The combination of the components (A) to (C) below, wherein the component (A) is 0.0001 to 3% by mass in the composition, and the component (B) is 0.0005 to 1% by mass in the composition. And (C) component for oral cavity containing 0.001-3 mass% in a composition.
11)
(A) Ginger oil (B) Mountain pepper and allyl isothiocyanate (C) Grapefruit oil The combination of the components (A) to (C) in the following 12), wherein the component (A) is 0.0001 to 3% by mass in the composition, and the component (B) is 0.0005 to 1% by mass in the composition. And (C) component for oral cavity containing 0.001-3 mass% in a composition.
12)
(A) One or more selected from cassia oil and nutmeg oil (B) Capsicum oleoresin (C) Gentian extract   Furthermore, 1 type or 2 or more types chosen from tranexamic acid, chlorhexidine hydrochloride, chlorhexidine gluconate, triclosan, isopropylmethylphenol, caffeine, phenoxyethanol, and dodecyl diaminoethyl glycine of any one of Claims 1-9. Oral composition.   It is a liquid mouthwash, The composition for oral cavity of any one of Claims 1-10.