JP2023532088A - Cosmetic composition with stabilized retinol - Google Patents

Abstract

from about 0.01% to about 3% by weight retinol; from about 0.01% to about 1% by weight tetra-di-t-butylhydroxyhydrocinnamate; from about 0.01% to about 3% by weight trisodium ethylenediamine disuccinate; from about 0.5% to about 7% by weight polyglyceryl-3 methylglucose distearate; from about 0.9% to about 7% by weight sodium polyacrylate; about 0.5% by weight % to about 8% by weight of an oil phase; and water, wherein all weight percentages are based on the total weight of the cosmetic composition. Additionally, cosmetic compositions are typically formulated to form oil-in-water emulsions. Also disclosed herein are methods of treating damaged skin with the cosmetic compositions. [Selection figure] None

Description

CROSS-REFERENCE TO RELATED APPLICATIONS This application claims the benefit of U.S. Application No. 16/916,496, filed June 30, 2020, and French Patent Application No. 2009032, filed September 7, 2020, which are hereby incorporated by reference in their entireties.

The present disclosure relates to cosmetic compositions with stabilized retinol. Additionally, aspects of the present disclosure relate to methods of treating damaged skin with cosmetic compositions.

Acting as a natural barrier between the internal and external environments, the skin plays a critical role in vital biological functions, such as protection against mechanical and chemical damage, microbiological, and UV damage. However, skin health and appearance can be degraded by environmental factors, genetic predisposition, nutrition, and sun exposure.

The environmental pollution situation is rapidly deteriorating and becoming more evident in the daily lives of consumers around the world. Pollution damage to human skin is also becoming increasingly apparent. Human skin is also subject to a variety of external injuries, such as ultraviolet (UV) radiation, environmental pollution, wind, heat, infrared radiation, low humidity, harsh surfactants, and abrasives. Recent studies suggest that in addition to UV irradiation, other environmental factors, particularly air pollution, contribute to the development of solar lentigines. Ultimately, these factors lead to visible signs of skin damage, such as small brown spots on the skin, especially in the elderly.

Typical skin damage includes fine lines, wrinkles, pigmentation, yellowing, sagging, dark circles under the eyes, puffy eyes, open pores, visible dead skin i.e. peeling, scaling, dryness, and rough skin. Consumers want to slow the build-up of skin damage, especially around the face and eyes, and reduce the effects of aging. A glowing and clear skin looks youthful and is a sign of good health and vitality. Therefore, there is a continuing need for new and improved formulations that improve skin health and visual appearance.

FIELD OF THE DISCLOSURE The present disclosure relates to cosmetic compositions having stabilized retinol, and in particular to cosmetic compositions that provide improved penetration of such retinol into adult human skin. The inventors have discovered that certain ingredients in certain amounts allow for a cosmetic composition that incorporates stable retinol so that the cosmetic composition can be contained in non-protective packaging.

A cosmetic composition according to one aspect of the present disclosure typically:
(a) from about 0.01% to about 3% by weight retinol;
(b) from about 0.01% to about 1% by weight of tetra-di-t-butylhydroxyhydrocinnamate;
(c) from about 0.01% to about 3% by weight of trisodium ethylenediamine disuccinate;
(d) from about 0.5% to about 7% by weight of polyglyceryl-3 methylglucose distearate;
(e) from about 0.9% to about 7% by weight sodium polyacrylate;
(f) from about 0.5% to about 8% by weight of an oil phase; and (g) water,
The cosmetic composition is an oil-in-water emulsion and all weight percentages are based on the total weight of the cosmetic composition.

In some examples, the cosmetic composition has a weight ratio of total trisodium ethylenediamine disuccinate to total sodium polyacrylate from about 1:1 to about 1:2, from about 1:1 to about 1:3, from about 1:1 to about 1:4, from about 1:1 to about 1:5; from about 1:1.5 to about 1:3, from about 1:1.5 to about 1:4, from about 1:1.5 to about 1:5; 3, about 1:2 to about 1:4, about 1:2 to about 1:5; about 1:2.5 to about 1:4, about 1:2.5 to about 1:5; about 1:3 to about 1:4, about 1:3 to about 1:5.

The cosmetic composition may contain an oil phase containing silicones. The oily phase may additionally or alternatively be coconut oil, soybean oil, canola oil, rape seed oil, corn oil, cottonseed oil, olive oil, palm oil, peanut oil, safflower oil, sesame oil, sunflower oil, linseed oil, palm kernel oil, persimmon oil, rapeseed oil, mustard oil, linseed oil, gumba shepherd's oil, castor oil, wheat germ oil, apricot kernel oil, pistachio oil, poppy seed oil. oil, pine oil, avocado oil, hazelnut oil, grape seed oil, rapeseed oil, juniper oil, peach kernel oil, coffee bean oil, jojoba oil, or mixtures thereof. In some cases, the oil phase may comprise fatty acid esters that are not polyglyceryl-3-methylglucose distearate, such as those selected from isononyl isononanoate, caprylic/capric triglycerides, and mixtures thereof.

The cosmetic composition may contain from about 0.05% to about 5% by weight of a thickening agent that is not sodium polyacrylate. Non-sodium polyacrylate thickeners can be selected from ammonium polyacryloyl dimethyl taurate, ammonium acryloyl dimethyl taurate/VP copolymer, sodium polyacrylate, acrylate copolymers, polyacrylamides, carbomers, acrylates/C10-30 alkyl acrylate crosspolymers, acrylates/beheneth-25 methacrylate copolymers and mixtures thereof.

In some cases, the cosmetic composition comprises from about 0.1% to about 10% by weight of a mattifying agent. Preferably, the matting agent comprises aluminum starch octenyl succinate.

Additionally or alternatively, the cosmetic composition comprises from about 1% to about 30% by weight polyol. Non-limiting examples of polyols include ethylene glycol, propylene glycol, butylene glycol, hexylene glycol, pentylene glycol, diethylene glycol, dipropylene glycol, caprylyl glycol, 1,3 propanediol, glycerin, diglycerin, polyethylene glycol, or mixtures thereof.

The cosmetic composition may contain from about 0.05% to about 5% by weight of the skin active agent. Examples of skin active agents include, for example, hyaluronic acid, niacinamide, lanolin, retinoids, retinal, adenosine, sodium hyaluronate, retinoic acid, carotenoids, panthenol, amino acids, proteins, enzymes, coenzymes, or mixtures thereof.

In some cases, the cosmetic composition is free of tocopherols. Additionally or alternatively, the cosmetic composition may be free of ascorbyl palmitate.

The present disclosure relates to cosmetic compositions having stabilized retinol and providing improved penetration of retinol into adult human skin. As noted above, the inventors have discovered that certain ingredients in certain amounts enable cosmetic compositions that incorporate stable retinol so that the cosmetic compositions can be contained in non-protective packaging. For example, the cosmetic composition can stabilize retinol such that after 8 weeks of storage at 45° C. in a light-tight glass container, the cosmetic composition does not exhibit phase separation and retains at least 75% by weight of retinol.

Surprisingly, in addition to stabilizing retinol, the cosmetic composition provides, in some cases, improved penetration of retinol into adult human skin. Typically, cosmetic compositions that seek to provide stable retinol utilize a large amount of oil phase in which retinol is dissolved. A cosmetic composition having a large amount of oil phase with retinol dissolved therein may contain a penetration enhancer to counteract the reduced penetration of retinol due to the large amount of oil phase. The inventors have discovered that certain embodiments of the cosmetic composition stabilize retinol while providing improved penetration of retinol into adult human skin.

According to one aspect of the present disclosure, typically:
(a) from about 0.01% to about 3% by weight retinol;
(b) from about 0.01% to about 1% by weight of tetra-di-t-butylhydroxyhydrocinnamate;
(c) from about 0.01% to about 3% by weight of trisodium ethylenediamine disuccinate;
(d) from about 0.5% to about 7% by weight of polyglyceryl-3 methylglucose distearate;
(e) from about 0.9% to about 7% by weight sodium polyacrylate;
(f) from about 0.5% to about 8% by weight of an oil phase; and (g) water, wherein the cosmetic composition is an oil-in-water emulsion, all weight percentages being based on the total weight of the cosmetic composition.

Preferably, the cosmetic composition does not phase separate and retains about 80% or more, about 82% or more, about 84% or more, about 86% or more, about 88% or more, about 90% or more, about 92% or more, about 94% or more, about 96% or more, about 98% or more, about 99% or more, or about 99.5% or more by weight of retinol after 8 weeks of storage in a light-tight glass container at 45°C. . The inventors were surprised that certain embodiments of the cosmetic composition retained 100% by weight of retinol and showed no phase separation after 8 weeks of storage at 45° C. in a light-tight glass container. In some cases, the cosmetic composition exhibits no phase separation after storage at 45° C. for 8 weeks in a light-tight glass container, retains about 80% or more by weight of retinol, and contains no more than about 5%, e. There was about 500 ppm or less, about 400 ppm or less, about 300 ppm or less, about 200 ppm or less, about 100 ppm or less, about 50 ppm or less oxygen in the container. In further cases, the cosmetic composition exhibits no phase separation after storage in a light-tight glass container at 45° C. for 8 weeks, retains about 80% by weight or more of retinol, and the cosmetic composition contains no more than 1000 ppm oxygen, e.g. ppm or less, about 50 ppm or less oxygen.

In some cases, the cosmetic composition achieves improved penetration of skin active agents into adult human skin. For example, the cosmetic composition can achieve penetration of skin active agents (eg, retinol) into the epidermis and dermis of the skin. In some cases, the cosmetic composition comprises about 2 μg/cm ² or greater, 2.1 μg/cm 2 or greater, 2.2 μg/cm ² or greater, 2.3 μg/cm ² or greater, 2.4 μg/cm ^{2 or} greater, 2.5 μg/cm ² or greater, 2.6 μg/cm ² or greater, 2.7 μg/cm ² or greater, 2.8 μg/cm ² or greater, 2.9 μg/cm ² or greater, 3 More than μg/cm ² of skin active agents (eg, retinol) can be obtained in the epidermis and dermis of human skin. In certain embodiments, the cosmetic composition obtains improved penetration of skin active agents without the use of penetration enhancers.

Some therapeutic or cosmetic compositions achieve epidermal penetration by using a carrier or vehicle that enhances skin penetration. Such carriers or vehicles, which are compounds or mixtures of compounds, are often described as "penetration enhancers" or "skin enhancers." Typical penetration enhancers that may optionally be excluded from cosmetic compositions include sulfoxides (dimethylsulfoxide, DMSO, etc.), azones (e.g. laurocapram), pyrrolidones, (e.g. 2-pyrrolidone, 2P), alcohols and alkanols (ethanol, or decanol), surfactants (also common in dosage forms) and terpenes. Some permeation enhancers can nest between the hydrophobic tails of the bilayer to disrupt its packing and increase fluidity, thus facilitating the diffusion of lipid-like permeants. The inventors have surprisingly discovered that certain cosmetic compositions according to the present disclosure provide improved penetration of retinol and/or other skin active agents into adult human skin without the use of specific penetration enhancers.

In some cases, the cosmetic composition has 5% or less, 4% or less, 3% or less, 2% or less, or 1% or less by weight of any one of the foregoing penetration enhancers. In at least one example, the cosmetic composition is free or essentially free of any one of the foregoing penetration enhancers. Additionally or alternatively, the cosmetic composition may have about 5% or less, 4% or less, 3% or less, 2% or less, or 1% or less by weight of the total amount of penetration enhancer. For example, the cosmetic composition may be free or essentially free of penetration enhancers.

The cosmetic composition may, in some cases, have 5% or less, 4% or less, 3% or less, 2% or less, or 1% or less by weight tocopherol. In at least one example, the cosmetic composition is free or essentially free of tocopherols. The cosmetic composition may have 5% or less, 4% or less, 3% or less, 2% or less, or 1% or less by weight ascorbyl palmitate. In at least one case, the cosmetic composition is free or essentially free of ascorbyl palmitate.

Cosmetic compositions are generally formulated as emulsions. Typically, cosmetic compositions are formulated to be oil-in-water emulsions in which the fatty phase is emulsified in the hydrophilic phase. However, in some instances, cosmetic compositions can be formulated to have a hydrophilic phase (eg, alcohol, glycol, polyol, etc.) emulsified in a fatty phase. The cosmetic composition can be formulated to be a lotion, serum, cream, spray, or any other suitable form of product.

The cosmetic composition may be packaged in a container containing a pump. The pump can be a standard push pump in some cases. Preferably, the container for the cosmetic composition is non-protective packaging. For example, in some instances, the cosmetic composition is contained in a container that does not include an aluminum layer or another metal layer that functions as an oxygen barrier.

Additionally, the present disclosure relates to a method of treating skin comprising applying to the skin a cosmetic composition of the present disclosure. The cosmetic compositions are additionally useful in methods of treating and/or repairing skin damage due to photoaging and reducing the appearance of wrinkles, age spots and uneven skin texture. The aforementioned methods may be non-therapeutic.

Suitable ingredients, such as those listed below, may be included or excluded in the formulation of the cosmetic composition, depending on the specific combination of other ingredients, the form of the cosmetic composition, and/or the use of the formulation (e.g., lotion, serum, gel, cream, spray, etc.).

Retinol Cosmetic compositions typically contain retinol in an amount of about 0.01% to about 3% by weight, based on the total weight of the cosmetic composition. For example, the amount of retinol present in the cosmetic composition, based on the total weight of the cosmetic composition, is from about 0.01% to about 3%, from about 0.01 to about 2.5%, from about 0.01 to about 2%, from about 0.01 to about 1.5%, from about 0.01 to about 1%, from about 0.01 to about 0.75%, from about 0.01 to about 0.5%; from about 0.05 to about 3 wt%, about 0.05 to about 2.5 wt%, about 0.05 to about 2 wt%, about 0.05 to about 1.5 wt%, about 0.05 to about 1 wt%, about 0.05 to about 0.75 wt%, about 0.05 to about 0.5 wt%; about 0.1 to about 1 wt%, about 0.1 to about 0.75 wt%, about 0.1 to about 0.5 wt%; 0.25 to about 3%, about 0.25 to about 2.5%, about 0.25 to about 2%, about 0.25 to about 1.5%, about 0.25 to about 1%, about 0.25 to about 0.75%, about 0.25% to about 0.5%.

In addition to retinol, the cosmetic composition may optionally include retinoids such as those selected from retinoic acid, retinyl esters, and other retinol derivatives. The amount of retinoid other than retinol present in the cosmetic composition is, based on the total weight of the cosmetic composition, for example, from about 0.01% to about 3%, from about 0.01 to about 2.5%, from about 0.01 to about 2%, from about 0.01 to about 1.5%, from about 0.01 to about 1%, from about 0.01 to about 0.75%, from about 0.01 to about 0.5%; about 0.05 to about 2.5 wt%, about 0.05 to about 2 wt%, about 0.05 to about 1.5 wt%, about 0.05 to about 1 wt%, about 0.05 to about 0.75 wt%, about 0.05 to about 0.5 wt%; about 0.1 to about 1 wt%, about 0.1 to about 0.75 wt%, about 0.1 to about 0.5 wt%; % by weight; about 0.25 to about 3% by weight, about 0.25 to about 2.5% by weight, about 0.25 to about 2% by weight, about 0.25 to about 1.5% by weight, about 0.25 to about 1% by weight, about 0.25 to about 0.75% by weight, about 0.25% to about 0.5% by weight.

Tetra-di-t-butyl hydroxyhydrocinnamate The cosmetic composition typically contains tetra-di-t-butyl hydroxyhydrocinnamate in an amount of from about 0.01% to about 1% by weight, based on the total weight of the cosmetic composition. In some examples, the amount of tetra-di-t-butylhydroxyhydrocinnamate present in the cosmetic composition is, based on the total weight of the cosmetic composition, from about 0.01% to about 1%, including ranges and subranges therebetween, from about 0.01 to about 0.8%, from about 0.01 to about 0.6%, from about 0.01 to about 0.4%, from about 0.01 to about 0.2%; about 0.05 to about 0.8%, about 0.05 to about 0.6%, about 0.05 to about 0.4%, about 0.05 to about 0.2%; about 0.1 to about 1%, about 0.1 to about 0.8%, about 0.1 to about 0.6%, about 0.1 to about 0.4%, about 0.1 to about 0.2%; about 0.15 to about 0.8 wt%, about 0.15 to about 0.6 wt%, about 0.15 to about 0.4 wt%;

Trisodium Ethylenediamine Disuccinate The cosmetic composition typically contains trisodium ethylenediamine disuccinate in an amount of about 0.01% to about 3% by weight, based on the total weight of the cosmetic composition. In some examples, the amount of tri-sodium ethylenediamine disuccinate present in the cosmetic composition is, based on the total weight of the cosmetic composition, from about 0.01 weight percent to about 3 weight percent, from about 0.01 to about 2.5 weight percent, from about 0.01 to about 2 weight percent, from about 0.01 to about 1.5 weight percent, from about 0.01 to about 1 weight percent, from about 0.01 to about 0.8 weight percent, about 0.01 to about 0.6 wt%, about 0.01 to about 0.4 wt%, about 0.01 to about 0.2 wt%, about 0.01 to about 0.1 wt%; 0.05 to about 0.6 wt%, about 0.05 to about 0.4 wt%, about 0.05 to about 0.2 wt%, about 0.05 to about 0.1 wt%; 0.15 to about 3 wt%, about 0.15 to about 2.5 wt%, about 0.15 to about 2 wt%, about 0.15 to about 1.5 wt%, about 0.15 to about 1 wt%, about 0.15 to about 0.8 wt%, about 0.15 to about 0.6 wt%, about 0.15 to about 0.4 wt%. % by weight; 0.2 to about 3% by weight, about 0.2 to about 2.5% by weight, about 0.2 to about 2% by weight, about 0.2 to about 1.5% by weight, about 0.2 to about 1% by weight, about 0.2 to about 0.8% by weight, or about 0.2% to about 0.6% by weight.

Polyglyceryl-3-methylglucose distearate The cosmetic composition comprises polyglyceryl-3-methylglucose distearate present in amounts that may vary, typically from about 0.5% to about 7% by weight, based on the total weight of the cosmetic composition. In some examples, the amount of polyglyceryl-3-methylglucose distearate in the cosmetic composition is, based on the total weight of the cosmetic composition, from about 0.5% to about 7%, from about 0.5% to about 6%, from about 0.5% to about 5%, from about 0.5% to about 4%, from about 0.5% to about 3%, from about 0.5% to about 2%, from about 0.5% to about 1%; about 0.75 to about 6 weight percent, about 0.75 to about 5 weight percent, about 0.75 to about 4 weight percent, about 0.75 to about 3 weight percent, about 0.75 to about 2 weight percent;

Sodium Polyacrylate The cosmetic composition typically contains sodium polyacrylate in an amount of about 0.9% to about 7% by weight, based on the total weight of the cosmetic composition. For example, the amount of sodium polyacrylate present in the cosmetic composition is, based on the total weight of the cosmetic composition, about 0.9% to about 7%, about 0.9 to about 6%, about 0.9 to about 5%, about 0.9 to about 4%, about 0.9 to about 3%, about 0.9 to about 2%, about 0.9 to about 1.5%; from about 6 wt%, from about 1 to about 5 wt%, from about 1 to about 4 wt%, from about 1 to about 3 wt%, or from about 1 to about 2 wt%;

Typically, the sodium polyacrylate may be present in the composition in particulate or non-particulate form. If the sodium polyacrylates are present in the form of fine particles, their average size in the hydrated state is preferably 10 μm or less, even more preferentially 5 μm or less. Their average size in the non-hydrated state is preferably 2 μm or less, preferably 1 μm or less.

Non-limiting examples of commercially available sodium polyacrylates include those sold under the names Octacare X100, X110 and RM100 by Avecia, those sold under the names Flocare GB300 and Flosorb 500 by SNF; Luquasorb 1003, Luquasorb 1010, Luquasorb by BASF 1280 and Luquasorb 1100; Water Lock G400 and G430 from Grain Processing (INCI name: acrylamide/sodium acrylate copolymer); Aqua Keep 10 SH NF, Aqua Keep 10 SH N supplied by Sumitomo Seika Co., Ltd. FC, Sodium Acrylate Crosspolymer-2; and/or Sanfresh ST-100C, ST100MC and IM-300MC from Sanyo Chemical Industries, Ltd. (INCI name: Sodium Grafted Starch Acrylate).

Oil The cosmetic composition comprises an oil phase comprising one or more oils. The amount of oil phase (eg, total amount of oil) is typically 0.5% to 8% by weight, based on the total weight of the cosmetic composition. The oil phase may comprise one or more oils such as silicone oils, fluoro oils, hydrocarbon-based oils, and the like. In some examples, the cosmetic composition comprises oils that are plant-based or vegetable-based oils.

The amount of oil and/or plant-based or vegetable-based oil present in the cosmetic composition is, based on the total weight of the cosmetic composition, from about 0.5% to about 8%, from about 0.5% to about 7%, from about 0.5% to about 6%, from about 0.5% to about 5%; from about 1% to about 8%, from about 1% to about 7%, from about 1% to about 6%, from about 1% to about 5%; about 8 wt%, about 2 to about 7 wt%, about 2 to about 6 wt%, about 2 to about 5 wt%; about 3 to about 8 wt%, about 3 to about 7 wt%, about 3 to about 6 wt%, about 3 to about 5 wt%; about 4 to about 8 wt%, about 4 to about 7 wt%, about 4 to about 6 wt%;

Additionally and/or alternatively, the cosmetic composition may exclude synthetic oils. In some cases, the cosmetic composition may exclude oils other than plant- and vegetable-based oils. For example, the amount of synthetic oils and/or oils other than plant-based and vegetable-based oils may be about 5% or less, about 4% or less, about 3% or less, about 2% or less, about 1% or less, or about 0.5% or less, by weight based on the total weight of the cosmetic composition. In at least one embodiment, the cosmetic composition is free or essentially free of synthetic oils and/or oils other than plant-based and vegetable-based oils.

The cosmetic composition may comprise an oil phase comprising low _O2 permeability oils (e.g., oils with an _O2 permeability of 0.3% or less); medium _O2 permeability oils (e.g., oils with an O2 permeability of 0.3% to 0.4%); and/or high _O2 permeability oils (e.g., oils with an _O2 permeability of greater than 0.4% ₎ . In some cases, the cosmetic composition comprises an amount of low _O2 permeability oil of about 50% or more, about 60% or more, about 70% or more, about 80% or more, about 85% or more, or about 90% or more by weight based on the total weight of the oil and/or oil phase. The cosmetic composition may comprise an amount of moderate _O2 permeable oil of about 50% or less, about 40% or less, about 30% or less, about 20% or less, about 10% or less, about 5% or less by weight. Additionally or alternatively, the cosmetic composition may comprise an amount of highly _O2 permeable oil of about 30% or less, about 20% or less, about 10% or less, about 5% or less by weight.

The term “oil” means any fatty substance that is in liquid form at room temperature (20-25° C.) and atmospheric pressure (760 mmHg). Often at least one of the oils in the cosmetic composition is part of the oil phase. "Oil phase" is a phase comprising at least one oil which may contain additional fat-soluble and lipophilic components and fatty substances. Oils suitable for use herein may be volatile or non-volatile. The term "volatile oil" relates to oils that can evaporate in less than one hour at room temperature and atmospheric pressure upon contact with the skin or keratin fibers. Volatile oils are liquid at room temperature and have a non-zero vapor pressure at room temperature and atmospheric pressure, especially in the range from 0.13 Pa to 40,000 Pa (10 ⁻³ to 300 mmHg). The term "non-volatile oil" relates to an oil that remains on the skin or keratin fibers for at least several hours at room temperature and atmospheric pressure, especially with a vapor pressure of less than ^10-3 mmHg (0.13 Pa).

The term “silicone oil” relates to oils containing at least one silicon atom, in particular at least one Si—O group. The term "fluoro oil" relates to oils containing at least one fluorine atom. The term "hydrocarbon-based oil" relates to oils containing primarily hydrogen and carbon atoms. The hydrocarbon base oil may be an animal hydrocarbon base oil, a vegetable hydrocarbon base oil, a mineral hydrocarbon base oil, or a synthetic hydrocarbon base oil. Additionally, suitable oils may be mineral hydrocarbon-based oils, vegetable hydrocarbon-based oils, or synthetic hydrocarbon-based oils.

Silicone Oils The cosmetic compositions described herein may comprise one or more silicone oils. Non-limiting examples of silicone oils include dimethicone, cyclomethicone, polysilicone-11, phenyltrimethicone, trimethylsilyl amodimethicone, and stearoxytrimethylsilane. In some cases, the cosmetic composition comprises additional oils including dimethicone and optionally additional silicone oils. Typically the one or more silicone oils are non-volatile silicone oils. In some embodiments, the silicone oil is polydimethylsiloxane (PDMS), a polydimethylsiloxane containing alkyl or alkoxy groups pendant and/or at the silicone chain ends (each of which contains from 2 to 24 carbon atoms), or phenylsilicones such as phenyltrimethicone, phenyldimethicone, phenyl(trimethylsiloxy)diphenylsiloxane, diphenyldimethicone, diphenyl(methyldiphenyl)trisiloxane, or (2-phenylethyl)trimethylsiloxy. It is silicate.

Other examples of silicone oils that may be mentioned include volatile linear or cyclic silicone oils, especially those having a viscosity of 8 centistokes (8× ¹⁰ m ² /s) and especially containing from 2 to 7 silicon atoms, these silicones optionally containing alkyl or alkoxy groups containing from 1 to 10 carbon atoms. As volatile silicone oils that can be used in the present invention, mention may be made in particular of octamethylcyclotetrasiloxane, decamethylcyclopentasiloxane, dodecamethylcyclohexasiloxane, heptamethylhexyltrisiloxane, heptamethyloctyltrisiloxane, hexamethyldisiloxane, octamethyltrisiloxane, decamethyltetrasiloxane, dodecamethylpentasiloxane and mixtures thereof.

Fluoro Oils The cosmetic compositions described herein may comprise one or more fluoro oils. For example, the one or more fluoro oils may be selected from the group consisting of perfluoromethylcyclopentane, perfluoro-1,3-dimethylcyclohexane, dodecafluoropentane, tetradecafluorohexane, bromoperfluorooctyl, nonafluoromethoxybutane, nonafluoroethoxyisobutane, and 4-trifluoromethylperfluoromorpholine. Volatile fluoro oils such as nonafluoromethoxybutane, decafluoropentane, tetradecafluorohexane, dodecafluoropentane may also be used.

Hydrocarbon-Based Oils The cosmetic compositions described herein may comprise one or more hydrocarbon-based oils. For example, hydrocarbon-based oils may be saturated hydrocarbons, unsaturated hydrocarbons, lipids, triglycerides, natural oils, and/or synthetic oils. In some embodiments, the composition comprises a synthetic oil selected from the group consisting of hydrogenated polyisobutene and hydrogenated polydecene.

Hydrocarbon-based oils may be non-volatile hydrocarbon-based, for example:
（ｉ）植物由来の炭化水素ベース油、例えばグリセリドトリエステルであり、概して脂肪酸およびグリセロールのトリエステルであり、その脂肪酸が、Ｃ _４からＣ _２４までの様々な鎖長を有することができ、これらの鎖が、飽和または不飽和、直鎖または分枝であることが可能であり、これらの油が、特に、コムギ胚芽油、ヒマワリ油、ブドウ種子油、ゴマ油、コーン油、アプリコット油、ヒマシ油、シア油、アボカド油、オリーブ油、ダイズ油、アーモンド油、パーム油、アブラナ種子油、綿実油、ヘーゼルナッツ油、マカダミア油、ホホバ油、アルファルファ油、ケシ油、カボチャ種子油、マロウ油（ｍａｒｒｏｗ ｏｉｌ）、クロスグリ油、月見草油、キビ油、オオムギ油、キヌア油、ライムギ油、サフラワー油、ククイナッツ油、パッションフラワー油、およびモスカータバラ油である、植物由来の炭化水素ベース油；
(ii) synthetic ethers containing from 10 to 40 carbon atoms;
(iii) linear or branched hydrocarbons of mineral or synthetic origin, such as petrolatum, polydecene, hydrogenated polyisobutenes such as Parleam, and 40 squalane;
（ｉｖ）合成エステル、例えば式ＲＣＯＯＲ'の油であり、式中、Ｒが、１個から４０個までの炭素原子を含有する直鎖または分枝状脂肪酸残基を表し、Ｒ'が、Ｒ＋Ｒ'が≧１０であるという条件で、１個から４０個までの炭素原子を含有する、特に分枝状である炭化水素ベースの鎖を表している油、例えばＰｕｒｃｅｌｌｉｎ ｏｉｌ（オクタン酸セテアリル）、ミリスチン酸イソプロピル、パルミチン酸イソプロピル、Ｃ _１２ ～Ｃ _１５アルキルベンゾエート、例えば、ＷｉｔｃｏからＦｉｎｓｏｌｖ ＴＮ（登録商標）もしくはＷｉｔｃｏｎｏｌ ＴＮ（登録商標）という商品名で販売されている製品、またはＥｖｏｎｉｋ ＧｏｌｄｓｃｈｍｉｄｔからＴｅｇｏｓｏｆｔ ＴＮ（登録商標）という商品名で販売されている製品、２－エチルフェニルベンゾエート、例えば、ＩＳＰからＸ－Ｔｅｎｄ ２２６の名称で販売されている市販品、ラノリン酸イソプロピル、ラウリン酸ヘキシル、アジピン酸ジイソプロピル、イソノナン酸イソノニル、エルカ酸オレイル、パルミチン酸２－エチルヘキシル、イソステアリン酸イソステアリル、セバシン酸ジイソプロピル、例えば、Ｓｔｅａｒｉｎｅｒｉｅ Ｄｕｂｏｉｓから「Ｄｕｂ Ｄｉｓ」の名称で販売されている製品、アルコールまたは多価アルコールのオクタノエート、デカノエートまたはリシノレエート、例えば、プロピレングリコールジオクタノエート；ヒドロキシル化エステル、例えば、乳酸イソステアリルまたはリンゴ酸ジイソステアリル；およびペンタエリスリトールエステル；シトレートまたはタルトレート、例えば、ジ（直鎖Ｃ _１２ ～Ｃ _１３アルキル）タルトレート、例えば、Ｅｎｉｃｈｅｍ Ａｕｇｕｓｔａ ＩｎｄｕｓｔｒｉａｌｅからＣｏｓｍａｃｏｌ ＥＴＩ（登録商標）の名称で販売されているもの、また、ジ（直鎖Ｃ _１４ ～Ｃ _１５アルキル）タルトレート、例えば、同社からＣｏｓｍａｃｏｌ ＥＴＬ（登録商標）の名称で販売されているもの；またはアセテート；
(v) fatty alcohols that are liquid at room temperature and contain branched and/or unsaturated carbon-based chains containing from 12 to 26 carbon atoms, such as octyldodecanol, isostearyl alcohol, oleyl alcohol, 2-hexyldecanol, 2-butyloctanol or 2-undecylpentadecanol;
(vi) higher fatty acids such as oleic acid, linoleic acid, linolenic acid;
(vii) carbonates, such as dicaprylyl carbonate, such as the product sold by Cognis under the name Cetiol CC®;
(viii) fatty amides, such as isopropyl N-lauroyl sarcosinate, such as the product sold under the trade name Eldew SL 205® by Ajinomoto Co.; Gamut oil, rosewood oil, cedar oil, chamomile oil, sage oil, clary sage oil, clove oil, cypress oil, eucalyptus oil, fennel oil, sea fennel oil, frankincense oil, geranium oil, ginger oil, grapefruit oil, jasmine oil, juniper oil, lavender oil, lemon oil, lemongrass oil, lime oil, mandarin oil, marjoram oil, myrrh oil, neroli oil, orange oil, patchouli oil, pepper oil, black pepper oil, petitgrain oil, pine oil, rose otto oil, rosemary oil, sandalwood oil, spearmint oil, licorice oil, vetiver oil, honeysuckle oil, and ylang ylang.

In particular examples, the non-volatile hydrocarbon base oils are glyceride triesters, especially caprylic/capric triglycerides, synthetic esters, especially isononyl isononanoate, oleyl erucate, _C12 - _C15 alkyl benzoates, 2-ethylphenyl benzoate, and fatty alcohols such as octyldodecanol.

Volatile hydrocarbon-based oils include hydrocarbon-based oils containing from ₈ to 16 carbon atoms, especially branched _C8 - _C16 alkanes, such as petroleum-derived C8- _C16 isoalkanes (also known as isoparaffins), such as isododecane (also known as 2,2,4,4,6-pentamethylheptane), isodecane or isohexadecane, Isopar or Permethyl. , branched C ₈ -C ₁₆ esters, and isohexyl neopentanoate.

Preferably, the oil is a vegetable- or vegetable-based oil, such as coconut oil, soybean oil, canola oil, rape seed oil, corn oil, cottonseed oil, olive oil, palm oil, peanut oil, safflower oil, sesame oil, sunflower oil, linseed oil, palm kernel oil, tung oil, rapeseed oil, mustard oil, flaxseed oil, turmeric oil, castor oil, wheat germ oil, apricot kernel oil, pista. selected from citrus oil, poppy oil, pine oil, avocado oil, hazelnut oil, grape seed oil, rapeseed oil, juniper oil, peach kernel oil, coffee bean oil, jojoba oil, and mixtures thereof.

Fatty Acid Esters Other than Polyglyceryl-3-Methylglucose Distearate The cosmetic composition may contain fatty acid esters other than polyglyceryl-3-methylglucose distearate. In some cases, fatty acid esters are considered part of the oil phase. Fatty acid esters other than polyglyceryl-3-methylglucose distearate can be glycerol fatty acid esters, sorbitan fatty acid esters, ethoxylated fatty acid esters, synthetic esters, and the like. A discussion of fatty acid esters other than polyglyceryl-3-methylglucose distearate that can be included in cosmetic compositions is provided below.

Glycerol Fatty Acid Esters Glycerol fatty acid esters that can be used as nonionic amphiphilic lipids can be selected in particular from the group comprising esters formed from at least one acid containing a saturated linear alkyl chain having from 16 to 22 carbon atoms and esters formed from from 1 to 10 glycerol units. One or more of these glycerol fatty acid esters may be used in the emulsions of this disclosure.

Sorbitan Fatty Acid Esters Sorbitan fatty acid esters that can be used as nonionic amphiphilic lipids can be selected in particular from the group comprising esters of C16-C22 fatty acids and sorbitan, and oxyethylenated esters of C16-C22 fatty acids and sorbitan. These are formed from at least one fatty acid containing at least one saturated linear alkyl chain, each having from 16 to 22 carbon atoms, and sorbitol or ethoxylated sorbitol. Oxyethylenated esters generally contain from 1 to 100 ethylene oxide units, preferably from 2 to 40 ethylene oxide (EO) units.

These esters can be chosen especially from stearates, behenates, arachidates, palmitates and mixtures thereof. Stearate and palmitate are preferably used.

Examples of sorbitan fatty acid esters and oxyethylenated sorbitan fatty acid esters are sorbitan monostearate (CTFA name: sorbitan stearate) sold by the company ICI under the name Span 60, sorbitan monopalmitate (CTFA name: sorbitan monopalmitate) sold by the company ICI under the name Span 40, or sorbitan 20 EO sold under the name Tween 65 by the company ICI. Mention may be made of tristearate (CTFA name: Polysorbate 65).

Ethoxylated Fatty Acid Esters Ethoxylated fatty acid esters that can be used as nonionic amphiphilic lipids are esters consisting of at least one fatty acid chain containing from 1 to 100 ethylene oxide units and from 16 to 22 carbon atoms. The fatty chain of the ester can be chosen especially from stearate, behenate, arachidate and palmitate units and mixtures thereof. As an example of etoxy fatty acid ester, stearic acid ester, which contains 40 ethylene oxide units, for example, products sold by ICI under the name of MYRJ 52 (CTFA name: PEG -40 Steering), and eight ethylene oxide units of Beheno acid. It can be mentioned on the product sold (CTFA name: PEG -8 Vegenating), for example, a product sold by GatteFosse under the name of COMPRITOL HD5 ATO.

Synthetic ester
Synthetic esters, such as oils of the formula RCOOR', where R represents a linear or branched fatty acid residue containing from 1 to 40 carbon atoms and R' represents a hydrocarbon-based chain, especially branched, containing from 1 to 40 carbon atoms, with the proviso that R+R' is ≧10, e.g. Purcellin oil (cetearyl octanoate), isopropyl myristate, Isopropyl palmitate, C₁₂～C₁₅Alkyl benzoates, for example the products sold by Witco under the trade name Finsolv TN® or Witconol TN®, or the products sold by Evonik Goldschmidt under the trade name Tegosoft TN®, 2-ethylphenyl benzoates, for example the commercial products sold by ISP under the name X-Tend 226, lanolinic acid Isopropyl, hexyl laurate, diisopropyl adipate, isononyl isononanoate, oleyl erucate, 2-ethylhexyl palmitate, isostearyl isostearate, diisopropyl sebacate, e.g. the products sold under the name "DubDis" by Stearinerie Dubois, octanoate, decanoate or ricinoleate of alcohols or polyhydric alcohols, e.g. propylene glycol dioctanoate hydroxylated esters, such as isostearyl lactate or diisostearyl malate; and pentaerythritol esters; citrates or tartrates, such as di(linear C₁₂～C₁₃alkyl) tartrates, such as those sold under the name Cosmacol ETI® by Enichem Augusta Industriale;₁₄～C₁₅alkyl) tartrates, such as those sold by the same company under the name Cosmacol ETL®; or acetates.

The amount of fatty acid ester that is not polyglyceryl-3-methylglucose distearate present in the cosmetic composition is, based on the total weight of the cosmetic composition, from about 0.5% to about 8%, from about 0.5% to about 7%, from about 0.5% to about 6%, from about 0.5% to about 5%; about 2 to about 8 wt%, about 2 to about 7 wt%, about 2 to about 6 wt%, about 2 to about 5 wt%; about 3 to about 8 wt%, about 3 to about 7 wt%, about 3 to about 6 wt%, about 3 to about 5 wt%; about 4 to about 8 wt%, about 4 to about 7 wt%, about 4 to about 6 wt%;

Thickening Agents Other than Sodium Polyacrylate The cosmetic compositions described herein may optionally contain thickening agents other than sodium polyacrylate. Thickening agents other than sodium polyacrylate are, based on the total weight of the cosmetic composition, about 0.05% to about 5%, about 0.05% to about 4%, about 0.05% to about 3%, about 0.05% to about 2%, about 0.05% to about 1%; 0.2% to about 5%, about 0.2% to about 4%, about 0.2% to about 3%, about 0.2% to about 2%, about 0.2% to about 1%; about 0.3% to about 5%, about 0.3% to about 4%, about 0.3% by weight; % to about 3%, about 0.3% to about 2%, or about 0.3% to about 1%.さらに、増粘剤の量は、化粧品組成物の総重量に基づいて、それらの範囲および部分範囲を含む、０．０５重量％、０．１重量％、０．２重量％、０．３重量％、０．４重量％、０．５重量％、０．６重量％、０．７重量％、０．８重量％、０．９重量％、１．０重量％、または１．５重量％から２重量％、３重量％、４重量％または５重量％までであってもよい。

Many thickeners are water soluble and increase the viscosity of water or form an aqueous gel when the cosmetic composition of the present invention is dispersed/dissolved in water. The aqueous solution may be heated, cooled, or neutralized to form a gel, as desired. When the thickener other than sodium polyacrylate is dispersed/dissolved in water, it may be dispersed/dissolved in a water-soluble aqueous solvent such as ethyl alcohol.

Thickeners are sometimes referred to as "thickeners" or "viscosity modifiers." Thickeners are typically included to increase the viscosity of the composition. Nonetheless, in some instances, certain thickeners provide additional and surprising benefits to the composition. Non-limiting examples of thickeners include polyacrylate crosspolymers (other than sodium polyacrylate) or crosslinked polyacrylate polymers (other than crosslinked sodium polyacrylate), cationic acrylate copolymers, anionic acrylic or carboxylic acid polymers, polyacrylamide polymers, polysaccharides such as cellulose derivatives, gums, polyquaterniums, vinylpyrrolidone homopolymers/copolymers, C8-24 hydroxyl-substituted fatty acids, C8-24 conjugated fatty acids, sugar fatty acid esters, polyglyceryl esters, and mixtures thereof. things are mentioned. Suitable thickeners other than sodium polyacrylate can be found in US patent application Ser. No. 16/731,654, which is incorporated herein in its entirety for all purposes.

Thickeners other than sodium polyacrylate can be selected from xanthan gum, guar gum, biosaccharide gum, cellulose, acacia seneca gum, sclerotium gum, agarose, pectin, gellan gum, hyaluronic acid. Additionally, thickeners other than sodium polyacrylate can include polymeric thickeners selected from the group consisting of ammonium polyacryloyldimethyltaurate, ammonium acryloyldimethyltaurate/VP copolymers, acrylate copolymers, polyacrylamides, carbomers, and acrylates/C10-30 alkyl acrylate crosspolymers.

Specific types of thickeners that may be mentioned include:
Carboxylic acid or carboxylate-based homopolymers or copolymers, which can be linear or crosslinked.

These polymers contain one or more monomers derived from acrylic acid (acrylates), substituted acrylic acids, and salts and esters of these acrylic acids and substituted acrylic acids. Commercially available polymers include those sold under the tradenames Carbopol, Acrysol, Polygel, Sokalan, Carbopol Ultrez, and Polygel. Examples of commercially available carboxylic acid polymers include carbomers, which are homopolymers of acrylic acid crosslinked with allyl ethers of sucrose or pentaerythrol. Carbomer is a B.I. F. Available as Carbopol 900 series from Goodrich (eg Carbopol 954). Still other suitable carboxylic acid polymeric agents include Ultrez 10 (B.F. Goodrich) and copolymers of C10-30 alkyl acrylates with one or more monomers of acrylic acid, methacrylic acid, or one of their short chain (i.e. C1-4 alcohol) esters, where the crosslinker is an allyl ether of sucrose or pentaerythrol. These copolymers are known as acrylates/C10-C30 alkyl acrylate crosspolymers and are known as B.I. F. They are commercially available from Goodrich as Carbopol 1342, Carbopol 1382, Pemulen TR-1, and Pemulen TR-2.

Other suitable carboxylic acid or carboxylate polymeric agents include copolymers of acrylic acid and alkyl C5-C10 acrylates, copolymers of acrylic acid and maleic anhydride, and polyacrylate crosspolymer-6. Polyacrylate Crosspolymer-6 is available from Seppic in a stock known as SEPIMAX ZEN.

Another suitable carboxylic acid or carboxylate polymeric agent includes acrylamidopropyltrimonium chloride/acrylate copolymer, a cationic acrylate copolymer (or quaternary ammonium compound) available as a raw material from Seppic known under the tradename SIMULQUAT HC 305.

In certain embodiments, the carboxylic acid or carboxylate polymeric thickeners useful herein are those selected from carbomers, acrylates/C10-C30 alkyl acrylate crosspolymers, polyacrylate crosspolymer-6, acrylamidopropyltrimonium chloride/acrylate copolymers, and mixtures thereof.

Polyquaternium compounds Non-limiting examples include Polyquaternium-1, Polyquaternium-2, Polyquaternium-3, Polyquaternium-4, Polyquaternium-5, Polyquaternium-6, Polyquaternium-7, Polyquaternium-8, Polyquaternium-9, Polyquaternium-10, Polyquaternium-11, Polyquaternium-12, Polyquaternium-13, Polyquaternium-14, Polyquaternium-15, Polyquaternium-16, Polyquaternium-17, Polyquaternium-18, Polyquaternium-19, Polyquaternium-20, Polyquaternium-21, Polyquaternium-22, Polyquaternium-23, Polyquaternium-24, Polyquaternium-25, Polyquaternium-26, Polyquaternium- 27, Polyquaternium-28, Polyquaternium-29, Polyquaternium-30, Polyquaternium-40, Polyquaternium-41, Polyquaternium-42, Polyquaternium-43, Polyquaternium-44, Polyquaternium-45, Polyquaternium-46, Polyquaternium-47, Polyquaternium-48, Polyquaternium-49, Polyquaternium Ternium-50, Polyquaternium-51, Polyquaternium-52, Polyquaternium-53, Polyquaternium-54, Polyquaternium-55, Polyquaternium-56, Polyquaternium-57, Polyquaternium-58, Polyquaternium-59, Polyquaternium-60, Polyquaternium-61, Polyquaternium-62, Polyquaternium-63, Polyquaternium-64, polyquaternium-65, polyquaternium-66, polyquaternium-67 and the like. In some cases, preferred polyquaternium compounds include polyquaternium-10, polyquaternium-11, polyquaternium-67, and mixtures thereof. In some examples, the cosmetic composition comprises Polyquaternium-10, Polyquaternium-11, Polyquaternium-67, or mixtures thereof.

Cellulose Non-limiting examples of cellulose include cellulose, carboxymethylhydroxyethylcellulose, cellulose acetate propionate carboxylate, hydroxyethylcellulose, hydroxyethylethylcellulose, hydroxypropylcellulose, hydroxypropylmethylcellulose, methylhydroxyethylcellulose, microcrystalline cellulose, sodium cellulose sulfate and mixtures thereof. In some examples, the cellulose is selected from water-soluble cellulose derivatives (eg, carboxymethylcellulose, methylcellulose, methylhydroxypropylcellulose, hydroxyethylcellulose, hydroxypropylcellulose, sodium cellulose sulfate). Further, in some instances the cellulose is preferably hydroxypropyl cellulose (HPC). In some examples, the cosmetic composition includes one or more cellulose thickeners (eg, microcrystalline cellulose, carboxymethylcellulose, hydroxymethylcellulose, and hydroxypropylcellulose).

Polyvinylpyrrolidone (PVP) and Copolymers Non-limiting examples include polyvinylpyrrolidone (PVP), polyvinylpyrrolidone (PVP)/vinyl acetate copolymer (PVP/VA copolymer), polyvinylpyrrolidone (PVP)/eicosene copolymer, PVP/hexadecene copolymer. Commercially available polyvinylpyrrolidones include Luviskol K30, K85, K90 available from BASF. Commercially available copolymers of vinylpyrrolidone and vinyl acetate include Luviskol VA37, VA64 available from BASF, and copolymers of vinylpyrrolidone, methacrylamide, and vinylimidazole (INCI: VP/methacrylamide/vinylimidazole copolymer) are commercially available from BASF as Luviset. PVP and PVP/VA copolymers are preferred in some instances.

Non-limiting examples of sucrose esters include sucrose palmitate, sucrose cocoate, sucrose monooctanoate, sucrose monodecanoate, sucrose mono- or dilaurate, sucrose monomyristate, sucrose mono- or dipalmitate, sucrose mono- and distearate, sucrose mono-, di- or trioleate, sucrose mono- or dilinoleate, sucrose pentaoleate, sucrose Suhexaoleate, sucrose heptaoleate or sucrose octooleate, and mixed esters such as sucrose palmitate/stearate, and mixtures thereof.

［式中、ｎは２から２０まで、または２から１０まで、または２から５までであり、または２、３、４、５、６、７、８、９、もしくは１０であり、Ｒ^１、Ｒ^２およびＲ^３は、それぞれ独立して脂肪酸部分または水素であってもよく、ただしＲ^１、Ｒ^２およびＲ^３の少なくとも１つが、脂肪酸部分である。例えば、Ｒ^１、Ｒ^２およびＲ^３は、飽和でも不飽和でもよく、直鎖でも分岐でもよく、Ｃ_１～Ｃ_４０、Ｃ_１～Ｃ_３０、Ｃ_１～Ｃ_２５、またはＣ_１～Ｃ_２０、Ｃ_１～Ｃ_１６、またはＣ_１～Ｃ_１０の長さを有してもよい。］追加的に、脂肪酸の非イオン性ポリグリセロールエステルの非限定的な例としては、ポリグリセリル－４カプリレート／カプレート、ポリグリセリル－１０カプリレート／カプレート、ポリグリセリル－４カプレート、ポリグリセリル－１０カプレート、ポリグリセリル－４ラウレート、ポリグリセリル－５ラウレート、ポリグリセリル－６ラウレート、ポリグリセリル－１０ラウレート、ポリグリセリル－１０ココエート、ポリグリセリル－１０ミリステート、ポリグリセリル－１０オレエート、ポリグリセリル－１０ステアレート、およびこれらの混合物が挙げられる。 Polyglyceryl Esters Non-limiting polyglycerol esters of fatty acids (polyglyceryl esters) include those of the formulas below.

[wherein n is 2 to 20, or 2 to 10, or 2 to 5, or 2, 3, 4, 5, 6, 7, 8, 9, or 10, and R1 ^, R2, and ^R3 may each independently be a fatty acid moiety or hydrogen, provided that at least one of ^R1 , ^{R2 ,} and ^R3 is a fatty acid moiety. For example, R ¹ , R ² and R ³ can be saturated or unsaturated, linear or branched, and can have lengths of C ₁ -C ₄₀ , C ₁ -C ₃₀ , C ₁ -C ₂₅ , or C ₁ -C ₂₀ , C ₁ -C ₁₆ , or C ₁ -C ₁₀ . ] Additionally, non-limiting examples of nonionic polyglycerol esters of fatty acids include polyglyceryl-4 caprylate/caprate, polyglyceryl-10 caprylate/caprate, polyglyceryl-4 caprate, polyglyceryl-10 caprate, polyglyceryl-4 laurate, polyglyceryl-5 laurate, polyglyceryl-6 laurate, polyglyceryl-10 laurate, polyglyceryl-10 cocoate, polyglyceryl- 10 myristate, polyglyceryl-10 oleate, polyglyceryl-10 stearate, and mixtures thereof.

C8-24 hydroxyl substituted fatty acids and C8-24 conjugated fatty acids Non-limiting examples include conjugated linoleic acid, cis-parinaric acid, trans-7-octadecenoic acid, cis-5,8,11,14,17-eicosapentaenoic acid, cis-4,7,10,13,16,19-docosahexaenoic acid, columbic acid, linolenic acid, ricinoleic acid Ricinolaidic acid, stearidonic acid, 2-hydroxystearic acid, alpha-linolenic acid, arachidonic acid, cis-11,14-eicosadienoic acid, linoleic acid, monopetroceric acid, petroselinic acid, ricinoleic acid, trans-vaccenic acid, cis-11,14,17-eicosatrienoic acid, cis-5-eicosenoic acid, cis-8 , 11,14-eicosatrienoic acid, hexadecatrienoic acid, palmitoleic acid, petroselaidic acid, transfarnesol, cis-13,16-docosadienoic acid, cis-vaccenic acid, cis-11-eicosenoic acid, cis-13,16,19-docosatrienoic acid, cis-13-octadecenoic acid, cis-15-octadecanoic acid, cis-7,10,1 3,16-docosatetraenoic acid, elaidic acid, gamma-linolenic acid, geranic acid, geranylgeranoic acid, linoleic acid, oleic acid, pinolenic acid, trans-13-octadecenoic acid. More preferably, the fatty acid comprises 12-hydroxystearic acid, conjugated linoleic acid, or mixtures thereof.

Non-limiting examples of gums include gum arabic, tragacanth gum, karaya gum, guar gum, gellan gum, tara gum, locust bean gum, tamarind gum, xanthan gum, locust bean gum, seneca gum, sclerotium gum, and the like.

Matting Agents The cosmetic compositions of the present disclosure may contain matting agents. The amount of matting agent in the cosmetic composition includes ranges and subranges therebetween based on the total weight of the cosmetic composition, such as from about 0.1% to about 10%, from about 0.1 to about 8%, from about 0.1 to about 6%, from about 0.1 to about 5%, from about 0.1 to about 4%, from about 0.1 to about 3%, from about 0.1 to about 2%, from about 0.1 to about 1%; 5 to about 10 weight percent, about 0.25 to about 8 weight percent, about 0.25 to about 6 weight percent, about 0.25 to about 5 weight percent, about 0.25 to about 4 weight percent, about 0.25 to about 3 weight percent, about 0.25 to about 2 weight percent, about 0.25 to about 1 weight percent; about 0.5 to about 4 weight percent, about 0.5 to about 3 weight percent, about 0.5 to about 2 weight percent, about 0.5 to about 1 weight percent; from about 10 wt%, from about 1 to about 8 wt%, from about 1 to about 6 wt%, from about 1 to about 5 wt%, from about 1 to about 4 wt%, from about 1 to about 3 wt%, or from about 1 wt% to about 2 wt%.

Matting agents (also referred to as “matting fillers”) refer to materials that impart a more transparent and hazy effect to the complexion and give the skin a natural and desirable appearance without giving it a greasy, shiny or glossy appearance. To do this, these materials are often adsorptive fillers, such as talc, silica, kaolin, or fillers with light-scattering optical properties, which are known under the name of the "soft focus" effect. In addition to reducing shine or greasiness, matting agents can contribute to the overall texture and thickness of the cosmetic composition. Matting agents are often (but not necessarily) particulate materials or powders.

Cosmetic compositions containing matting agents can be characterized by the following protocol. The test composition is spread at a rate of 2 mg/cm ² onto a contrast card (Prufkarte type 24/5-250 cm ² from Erichsen) using a mechanical film spreader. The composition is then dried overnight at 37° C. and its reflectance is measured using a gonioreflectometer sold by Micromodule. The specularly reflected intensity (R) at 30° and the scattered intensity (D) at 90° are continuously measured. The result obtained is the ratio R between specular and diffuse reflection. The value of R is proportionately smaller the greater the matting effect provided by the filler. A value of R of 2 or less generally indicates a matting effect. Matting agents according to the present disclosure preferably include those that give an R value of less than 1.5, preferably less than 1, at a content of 5% in the cosmetic composition.

Non-limiting examples of matting agents include silicas, clays, silicate derivatives, hydrophobic silica airgel particles, porous silica microparticles such as silica beads SB150 and SB700 from Miyoshi Kasei Co., Ltd. with an average size of 5 microns; Fluoroethylene powder, such as Clariant's PTFE Ceridust 9205F with an average size of 8 microns; silicone resin powder, such as GE Silicone's silicone resin Tospearl 145A with an average size of 4.5 microns; Acrylates, e.g., PMMA particles Jurymer MBI from Nihon Junyoki with an average size of 8 microns, hollow PMMA spheres sold by Wackher under the name Covabead LH 85, and expanded microspheres of vinylidene chloride/acrylonitrile/methylene methacrylate sold under the name Expancel; wax powders, e.g., Mic with an average size of 7 microns Paraffin wax particles MicroEase 114S from RoPowders, a polyethylene powder, especially a polyethylene powder comprising at least one ethylene/acrylic acid copolymer, especially consisting of an ethylene/acrylic acid copolymer, such as Flobeads EA209 particles (10 microns average size) from Sumitomo Chemical Co., Ltd., a crosslinked elastomeric organopolysiloxane powder coated with a silicone resin, particularly a silsesquioxane resin, see, for example, U.S. Pat. No. 5,538,793. (such elastomer powders are sold by Shin-Etsu Chemical Co., Ltd. under the names KSP-100, KSP-101, KSP-102, KSP-103, KSP-104, and KSP-105); polyamide (Nylon.RTM.) powders, such as Atofina's Orgasol type nylon 12 particles with an average size of 10 microns; polymethyl methacrylate (PMMA) type powders; Talc, silica/TiO₂or silica/zinc oxide composites, styrene/acrylic copolymer powders, and mixtures thereof.

Among the clays, clays of the smectite class, such as laponite, clays of the kaolinite class, such as kaolinite, dickite or nacrite, halloysite, dombassite, antigorite, benthierine or optionally modified clays of the pyrophyllite class, montmorillonite, beidellite, vermiculite, talc, stevensite, hectorite, Mention may be made of saponite, chlorite, sepiolite and illite.

Clay is described, for example, in the publication Mineralogie des argiles [Minerology of Clays], S.M. Caillere, S. Henin, M.; Rautureau, 2nd edition 1982, Masson, which is incorporated herein by reference in its entirety. Natural clays are sedimentary rocks composed mostly of certain minerals, silicates, commonly aluminum. Kaolin is a natural clay. Clays may also be synthetic. Clays can also be chemically modified with various compounds such as acrylic acid, polysaccharides (eg carboxymethylcellulose), or organic cations. In some examples, the cosmetic compositions of the present disclosure comprise clays selected from the group consisting of kaolinite, montmorillonite, saponite, laponite, hectorite (including disteardimonium hectorite), and illite.

Silica derivatives that may be mentioned include silica powders, for example the porous silica microspheres sold under the name Silica Beads SB-700 sold by Miyoshi Kasei Co. Ltd., the products Sunsphere H51, Sunsphere H33 and Sunsphere H53 sold by AGC Ltd.; H-33, and polydimethylsiloxane-coated amorphous silica microspheres sold under the names SA Sunsphere H-53; silica microbeads, such as those sold under the name SB150 by Miyoshi Kasei Co., Ltd.;

In some examples, the cosmetic composition includes methyl methacrylate/glycol dimethacrylate crosspolymer, vinyl dimethicone/methicone silsesquioxane crosspolymer, methyl methacrylate crosspolymer, nylon 12, polyamide, polyethylene, talc, titanium dioxide, silica, aluminum starch octenyl succinate, clays (such as hectorite clays including distearidimonium hectorite), silica, polymethysilsequioxane. oxane), and one or more matting agents selected from the group consisting of mixtures thereof. Preferably, the matting agent, if present, is aluminum starch octenyl succinate.

Polyol The cosmetic composition may comprise one or more polyols. The amount of polyol in the cosmetic composition, if present, may range from about 1% to about 30% by weight, based on the total weight of the cosmetic composition. For example, the cosmetic composition may contain, based on the total weight of the cosmetic composition, from about 1% to about 30%, from about 1% to about 25%, from about 1% to about 20%, from about 1% to about 18%, from about 1% to about 16%, from about 1% to about 14%, from about 1% to about 12%, from about 1% to about 10%; about 20 wt%, about 5 to about 18 wt%, about 5 to about 16 wt%, about 5 to about 14 wt%, about 5 to about 12 wt%, about 5 to about 10 wt%; about 14 to about 30 wt%, about 14 to about 25 wt%, about 14 to about 20 wt%, about 14 to about 18 wt%; about 16 to about 30 wt%, about 16 to about 25 wt%, about 16 to about 20 wt%; about 18 to about 30 wt%, about 18 to about 25% by weight, may include water-soluble solvent in an amount of about 18% to about 20% by weight.

Polyhydric alcohols are useful. The term "polyol" should be understood within the meaning of this disclosure to mean an organic molecule containing at least two free hydroxyl groups. The polyols of the cosmetic composition can be glycols or compounds with multiple hydroxyl groups. In some cases, the one or more polyols are selected from the group consisting of _C2 - _C32 polyols. The one or more polyols may be liquid at ambient temperature (25° C.). The one or more polyols can have 2 to 32 carbon atoms, 3 to 16 carbon atoms, or 3 to 12 carbon atoms.

Non-limiting examples of polyols that may optionally be included in the cosmetic composition are alkanediols such as glycerin, 1,2,6-hexanetriol, trimethylolpropane, ethylene glycol, propylene glycol, butylene glycol, pentylene glycol, hexylene glycol, diethylene glycol, triethylene glycol, tetraethylene glycol, pentaethylene glycol, dipropylene glycol, 2-butene-1,4-diol, 2-ethyl-1,3-hexanediol, 2-methyl-2,4- pentanediol, caprylyl glycol, 1,2-hexanediol, 1,2-pentanediol and 4-methyl-1,2-pentanediol; glycol ethers such as ethylene glycol monomethyl ether, ethylene glycol monoethyl ether, ethylene glycol monobutyl ether, ethylene glycol monomethyl ether acetate, diethylene glycol monomethyl ether, diethylene glycol monoethyl ether, diethylene glycol mono-n-propyl ether, ethylene glycol monoisopropyl ether, diethylene glycol mono-iso-propyl ether, ethylene glycol mono-n-butyl ether, and/ or selected from these. The one or more polyols may optionally be glycols or glycol ethers such as monomethyl, monoethyl and monobutyl ethers of ethylene glycol, propylene glycol or its ethers such as propylene glycol, butylene glycol, hexylene glycol, monomethyl ether of dipropylene glycol, and alkyl ethers of diethylene glycol such as monoethyl or monobutyl ether of diethylene glycol.

In some cases, the polyol is glycerin, ethylene glycol, diethylene glycol, triethylene glycol, propylene glycol, dipropylene glycol, tripropylene glycol, 1,3-butanediol, 2,3-butanediol, 1,4-butanediol, 3-methyl-1,3-butanediol, 1,5-pentanediol, tetraethylene glycol, 1,6-hexanediol, 2-methyl-2,4-pentanediol, polyethylene glycol, 1,2,4-butanetri ol, 1,2,6-hexanetriol and mixtures thereof. A polyol compound may also be used. Non-limiting examples include aliphatic diols such as 2-ethyl-2-methyl-1,3-propanediol, 3,3-dimethyl-1,2-butanediol, 2,2-diethyl-1,3-propanediol, 2-methyl-2-propyl-1,3-propanediol, 2,4-dimethyl-2,4-pentanediol, 2,5-dimethyl-2,5-hexanediol, 5-hexene-1,2-diol and 2 -ethyl-1,3-hexanediol and mixtures thereof.

In some cases, the polyol is selected from ethylene glycol, propylene glycol, butylene glycol, hexylene glycol, pentylene glycol, diethylene glycol, dipropylene glycol, caprylyl glycol, 1,3 propanediol, glycerin, diglycerin, polyethylene glycol and mixtures thereof.

Skin Active Agents Cosmetic compositions may optionally include one or more skin active agents such as anti-aging agents, anti-wrinkle actives, antioxidants, humectants, moisturizing ingredients, depigmenting agents, and/or agents for treating oily skin. A skin-active agent may be included in the cosmetic composition in an amount ranging from greater than 0 to about 5% by weight, based on the total weight of the composition. For example, the total amount of skin-active agent, based on the total weight of the cosmetic composition, including ranges and subranges therebetween, from greater than zero to about 4%, from greater than zero to about 3%, from greater than zero to about 2%; about 10 ppm to about 0.5 weight percent (5,000 ppm), about 10 ppm to about 0.3 weight percent (3,000 ppm), about 10 ppm to about 0.2 weight percent (2,000 ppm), about 10 ppm to about 0.1 weight percent (1,000 ppm), about 10 ppm to 500 ppm; about 0.1 to about 5%, about 0.1 to about 2.5%, about 0.1 to about 1%, about 0.1 to about 0.5%; about 1 to about 5%, about 1 to about 4%, about 1 to about 3%; about 2 to about 5%, about 2 to about 4%; or about 3% to about 5%.

A non-limiting discussion of skin-active agents that may be included in cosmetic compositions in some cases is provided below.

Humectants and/or Moisturizing Ingredients Examples of humectants and/or moisturizing ingredients include glycerol and its derivatives, urea and its derivatives, in particular Hydrovance, which is commercially available from National Starch, hyaluronic acid, sodium pidolate, xylitol, serine, ectoine and its derivatives, collagen, plankton, Imperata schilindra, which is sold under the name Moist 24 by Sederma. ylindra), homopolymers of acrylic acid such as Lipidure-HM from NOF Corporation, β-glucans, especially sodium carboxymethyl beta-glucan from Mibelle-AG-Biochemistry, mixtures of oils of passionflower, apricot, corn and rice bran sold under the name NutraLipids by Nestle, C-glycoside derivatives, especially from Chimex. C-13-D-xylopyranoside-2-hydroxypropane in the form of a solution of 30% by weight of active substance in a water/propylene glycol mixture (60/40% by weight), such as the product manufactured under the trade name "Mexoryl SBB"; Prophyridium cruentum extract, marine-derived collagen and chondroitin sulfate spheres (Atelocollagen) sold by Engelhard Lyon under the name Marine Filling Spheres, hyaluronic acid spheres such as those sold by Engelhard Lyon, and arginine.

Depigmenting Agents Depigmenting agents that may be incorporated in cosmetic compositions include alpha and beta arbutin, rucinol and its derivatives, kojic acid, resorcinol and its derivatives, homogentisic acid, methyl gentisate or homogentisate, diacids, D pantheteine calcium sulphonate, lipoic acid, ellagic acid, vitamin B3, linoleic acid and its derivatives. certain compounds derived from plants such as chamomile, quail, aloe (vera, ferox, bardensis), mulberry, skullcap, Actinidia chinensis commercially available from Gattefosse, root extracts of Paeonia suffruticosa, e.g. Those sold by Ichimaru Farcos Co., Ltd. under the name Liquid Botanpi Be, extracts of sugarcane (Saccharum officinarum), for example those selected from molasses extracts marketed by Taiyo Kagaku Co., Ltd. under the name Liquid Molasses, but this list is not exhaustive. Specific depigmenting agents include alpha and beta arbutin, kojic acid, resorcinol and its derivatives, D pantetheine calcium sulfonate, lipoic acid, ellagic acid, vitamin B3, Actinidia chinensis commercially available from Gattefosse, Paeonia suffruticosa root extract, e.g. Includes those sold under the name uid B.

Anti-Wrinkle Actives The cosmetic composition may comprise one or more anti-wrinkle actives. The term "anti-wrinkle active agent" refers to a natural or synthetic compound that, when brought into contact with an area of wrinkled skin, produces a biological effect, e.g., an increase in the synthesis and/or activity of certain enzymes, which has the effect of reducing the appearance of wrinkles and/or fine lines. Exemplary anti-wrinkle active agents include desquamating agents, anti-glycation agents, inhibitors of NO-synthase, agents that stimulate the synthesis of dermal or epidermal macromolecules and/or prevent their degradation, agents for stimulating proliferation of fibroblasts and/or keratinocytes, or agents for stimulating keratinocyte differentiation-reducing agents; muscle relaxants and/or dermo-decontracting agents, anti-free radical agents, and mixtures thereof. Examples of such compounds include adenosine and its derivatives and retinoids other than retinol (described above), ascorbic acid and its derivatives such as magnesium ascorbyl phosphate and ascorbyl glucoside; nicotinic acid and its precursors such as nicotinamide; ubiquinone; and derivatives thereof, in particular C-beta-D-xylopyranoside-2-hydroxypropane as described in EP-1345919, plant extracts including extracts of sea fennel and olive leaves, and plant and hydrolysates thereof, such as rice protein hydrolysates or soy protein; f3-hydroxy acids, such as salicylic acid, and n-octanoyl-5-salicylic acid oligopeptides, and pseudodipeptides and their acyl derivatives, especially the acid {2-[acetyl-(3-trifluoromethyl-phenyl)-amino]-3-methyl}acetic acid), and lipopeptides marketed by that company under the trade names SEDERMA Matrixyl 500 and Matrixyl 3000; lycopene, manganese salts and magnesium salts; Gluconate, as well as mixtures thereof, may be mentioned in particular. In at least one case, the cosmetic composition contains adenosine derivatives, such as non-phosphate derivatives of adenosine, such as especially 2′-deoxyadenosine, 2′,3′-adenosine isopropylidene; toyocamycine, 1-methyladenosine, N-6-methyladenosine; adenosine N-oxide, 6-methyl Including mecaptopurine riboside, and 6-chloropurine riboside. Other derivatives include adenosine receptor agonists such as adenosine phenylisopropyl (“PIA”), 1-methylisoguanosine, N6-cyclohexyladenosine (CHA), N6-cyclopentyladenosine (CPA), 2-chloro-N6-cyclopentyladenosine, 2-chloroadenosine, N6-phenyladenosine, 2-phenylaminoadenosine, MECA, N6-phenethyladenosine. Included are denosine, 2-p-(2-carboxy-ethyl)phenethyl-amino-5'-N-ethylcarboxamidoadenosine (CGS-21680), N-ethylcarboxamido-adenosine (NECA), 5'(N-cyclopropyl)-carboxamidoadenosine, DPMA (PD 129 944) and metrifudil.

Skin Active Agents for Oily Skin The cosmetic composition may optionally contain a skin active agent for dealing with oily skin. These agents may be sebum-regulating or anti-seborrheic agents capable of regulating the activity of the sebaceous glands. Exemplary skin active agents for dealing with oily skin include retinoic acid, retinol, benzoyl peroxide, sulfur, vitamin B6 (pyridoxine or) chloride, selenium, samphire--a blend of cinnamon extracts, tea tree and octanoylglycine, such as--15 Seppicontrol A5 TEA from Seppic--marketed under the tradename Seppicontrol A5, especially by Seppic. mixtures of cinnamon, sarcosine and octanoylglycine--zinc salts such as zinc gluconate, zinc pyrrolidonecarboxylate (or zinc pidolate), zinc lactate, zinc aspartate, zinc carboxylate, zinc salicylate 20, zinc cysteate;--especially copper and copper pidolate derivatives such as Cuivridone Solabia--for example Arnica montana, all commercially available from Maruzen Pharmaceutical Co., Ltd.; Cinchona succirubra, Eugenia caryophyllata, Hops (Humulus lupulus), Hypericum perforatum, Mentha pipenta 25 Rosemary (Rosmarinus o fficinalis), sage (Salvia officinalis) and thymus vulgaris (Thymus vulgaris) plants--extracts of Spiraeaulmaria, such as those sold under the name Sebonormine by Silab--algae Laminaria sac charina), such as that sold under the 30 name Phlorogine by Biotechmarine--root extract of the burnet mixture (Sanguisorba officinalis/Poterium officinale), rhizome and cinnamon of ginger (Zingiber officinalis). (Cinnamomum cassia), e.g. sold under the name Sebustop by Solabia--extracts of linseed, e.g. sold under the name Lumine by Lucas Meyer, yellowfin tuna extracts, e.g. sold under the name Oubaku liquid B by Co., Ltd.--mixed extracts of Serenoa serrulata (saw palmetto) extract and argan oil of sesame seeds, such as those sold under the name ReguSEB by Pentapharm; and a mixture of extracts of bioavailable zinc (microalgae), such as those sold under the name Seborilys Green Tech;--extracts of Pygeum afrianum, such as those sold by Euromed under the name Pygeum afrianum sterolic lipid extract--Serenoa serlata. (Serenoa serrulata), such as those sold under the name Viapure Sabal by Actives International and those sold by Euromed--a blend of plantains, an extract of Berberis aquifolium and sodium salicylate 20, such as Seboclear Rahn -- clove extract, e.g., sold under the name Clove extract powder by Maruzen Pharmaceutical Co., Ltd. -- argan oil, e.g., sold under the name Lipofructyl Laboratories Serobiologiques; Seaweed kelp extract, such as sold under the name Laminargane by Biotech marine -- Oligosaccharide seaweed Laminaria digitata, such as sold under the name Phycosaccharide 30 AC by Codif -- Extract of sugar cane, such as Policos by Sabinsa anol, sulfonated shale oil, e.g. from Ichthyol under the name Ichtyol Pale, extracts of Spiraea ulmaria, e.g. sold under the name Cytobiol Ulmaire by societe Libiol--sebacic acid, especially Sederm in the form of sodium polyacrylate gel. a - glucomannan extracted from konjac tubers and modified with alkyl sulfonate chains, e.g. marketed under the name Biopol Beta by Arch Chemical - extracts of Sophora angustifolia, e.g. Sophora powder or Sophora from Bioland extract--extract of cinchona succirubra bark, e.g. sold under the name RedBark HS by Alba Muller--extract of Quillaja saponaria, e.g. under the name 15 Panamawood HS from Alba Muller. -- Glycine grafted onto undecylene chains, such as those sold under the name Lipacide UG OR by SEPPIC -- mixtures of oleanolic acid and nordihydroguaiaretic acid, such as those sold by Sederma, AC. Net; 20--phthalimidoperoxyhexanoic acid--Sasol to COSMACOL. RTM. citrate tri (C12-C13) sold under the name ECI; Sasol to COSMACOL. RTM. 10-Hydroxydecanoic acid including trialkylcitrate (C14-C15)--mixed acids-hydroxydecanoic October 25 sold under the name ECL, sebacic acid, and 1,10-decanediol, such as those sold by Vincience under the name Acnacidol BG, and mixtures thereof. .

Antioxidants Vitamin C and derivatives can be used, including ascorbic acid, sodium ascorbate, and the fat-soluble esters tetrahexyldecylascorbate and ascorbyl palmitate, magnesium ascorbyl phosphate, ascorbyl glucoside, glucosamine ascorbate, ascorbyl acetate, and the like. Additionally, bioflavonoids from extracts from plants containing high amounts of vitamin C, such as camu camu berries (Myrciaria dubia), acerola, emblica officinalis, and rosehip and citrus fruits can be used, and water-soluble bioflavonoids such as hesperidin methylchalcone can be used.

Also, sesame (Sesamum indicum) or sesame lignans may be added. Sesame and its lignans (fibrous compounds related to sesame) act as antioxidants. Sesame seed lignans greatly enhance vitamin E activity.

Other antioxidants include tocopherols (e.g. d-α-tocopherol, d-β-tocopherol, d-γ-tocopherol, d-delta-tocopherol), tocotrienols (e.g. d-α-tocotrienol, d-β-tocotrienol, d-γ.-tocotrienol, d-delta-tocotrienol) and vitamin E (α-tocopherol acetate). These compounds may be isolated from natural sources, prepared by synthetic means, or mixtures thereof. A tocotrienol-enriched vitamin E preparation can be obtained by fractionating a vitamin E preparation, removing part of the tocopherols, and recovering a preparation with a higher tocotrienol concentration. Useful tocotrienols are natural products isolated, for example, from wheat germ oil, cereals, or palm oil using high performance liquid chromatography, or from barley, brewer's grains, oats by alcoholic extraction and/or molecular distillation. As used herein, the term "tocotrienols" includes not only the pure compounds, but also the tocotrienol-rich fractions obtained from these natural products. Increased glutathione peroxidase activity protects skin from oxidative damage.

In addition, carotenoids, particularly xanthophyll-based carotenoids, are also useful antioxidants that can be used. The xanthopyl carotenoids include molecules such as lutein, canthaxanthin, cryptoxanthin, zeaxanthin, and astaxanthin. Xanthophylls protect compounds such as vitamin A, vitamin E, and other carotenoids.

Flavonoids The skin-active agent may be an antioxidant selected from the group of flavonoids. In some examples, the flavonoid is a flavanone (a derivative of 2,3-dihydro-2-phenylchromen-4-one). Flavones include butine, eriodictyol, hesperetin, hesperidin, homoeriodictyol, isosakuranetin, naringenin, naringin, pinocembrin, poncilin, sakuranetin, sakuranin, and sterbin. The flavonoid may be a flavanonol (derivative of 3-hydroxy-2,3-dihydro-2-phenylchromen-4-one). Flavanols include taxifolin, aromadrin, chrysandroside A, chrysandroside B, xeractinol, astilbin, and fustin. The flavonoid may be a flavone (a derivative of 2-phenylchromen-4-one). Flavones include apigenin, luteolin, tangeritin, chrysin, baicalein, scutellarein, ougonin, synthetic flavones: diosmin and flavoxate. Flavonoids may be flavonols (derivatives of 3-hydroxy-2-phenylchromen-4-one). Flavonols include 3-hydroxyflavone, azaleatin, fisetin, galangin, gossipetin, kaemperide, kaempferol, isorhamnetin, morin, myricetin, natsudaidyne, pachypodol, quercetin, rhamnadin, rhamnetin, azalein, hyperoside, isoquercitin, kaemperithrin, myricitrin, quercitrin, robinin, rutin, spireoside, and xantrum. Nin, amlensin, icariin, and troxerutin. The flavonoid may be flavan-3-ol (a derivative of 2-phenyl-3,4-dihydro-2H-chromen-3-ol). Flavan-3-ols include catechin, epicatechin, epigallocatechin, epicatechin gallate, epigallocatechin gallate, epiafzelekin, fisetinidol, giburtinidol, mesquitol and robinetinidol. The flavonoid may be flavan-4-ol (a derivative of 2-phenylchroman-4-ol). Flavan-4-ols include apiphorol and luteophorol. Flavonoids may be isoflavones (derivatives of 3-phenylchromen-4-one). Isoflavones include genistein, daidzein, biochanin A, formononetin and equol metabolites from daidzein.

Antioxidants may be anthocyanidins (derivatives of the 2-phenylchromenylium cation). Anthocyanidins include aurantinidin, cyanidin, delphinidin, europinidin, luteolinidin, pelargonidin, malvidin, peonidin, petunidin, rosinidin and xanthones.

The antioxidant may be a dihydrochalcone (a derivative of 1,3-diphenyl-1-propanone). Dihydrochalcones include phloretin, dihydrochalcone phloretin phlorizin, aspalathin, naringin dihydrochalcone, neohesperidin dihydrochalcone and notofagin. Without limiting the mechanism of action of the present invention, dihydrochalcones can exert antioxidant activity by reducing reactive free radicals such as reactive oxygen and reactive nitrogen species.

The antioxidant may be an anthocyanin. Anthocyanins and their derivatives are antioxidants. Anthocyanins encompass a class of flavonoid compounds, which are naturally occurring water-soluble compounds responsible for the red, purple, and blue colors of many fruits, vegetables, grains, and flowers. Additionally, anthocyanins are collagenase inhibitors. Inhibition of collagenase is useful for prevention and reduction of wrinkles caused by reduction of skin collagen, improvement of skin elasticity, and the like. Anthocyanins can be obtained from any part of a variety of plant sources, including fruits, flowers, stems, leaves, roots, bark, or seeds. Those skilled in the art will appreciate that certain parts of plants may contain higher natural levels of anthocyanins and thus those parts are used to obtain the desired anthocyanins. In some examples, antioxidants may include one or more betacyanins. Betacyanins, like anthocyanins, can be obtained from natural sources and are antioxidants.

The antioxidant may be a phenylpropanoid (a derivative of cinnamic acid). Phenylpropanoids include cinnamic acid, caffeic acid, ferulic acid, trans-ferulic acid (including its antioxidant pharmacore 2,6-dihydroxyacetophenum), 5-hydroxyferulic acid, sinapic acid, coumaryl alcohol, coniferyl alcohol, sinapyl alcohol, eugenol, funicol, safrole, p-coumaric acid and sinapinic acid. Without limiting the mechanism of action of the present invention, phenylpropanoids can neutralize free radicals.

The antioxidant may be chalcone (a derivative of 1,3-diphenyl-2-propen-1-one). Chalcones include butein, okanin, carthamine, malein, sophorazine, xanthohumol, flavocvain A, flavocabine B, flavocabin C, and synthetic safalcone.

The antioxidant may be a curcuminoid. Curcuminoids include curcumin, desmethoxycurcumin, bis-desmethoxycurcumin, tetrahydrocurcumin, and tetrahydrocurcuminoids. Curcumin and tetrahydrocurcuminoids may be derived from the rhizome of turmeric (Curcuma longa). Tetrahydrocurcumin, a metabolite of curcumin, has been found to be a more potent antioxidant and more stable than curcumin.

Antioxidants may be tannins. Tannins include tannins, terflavin B, glucogallin, Dgallic acid, and quercitannic acid.

Antioxidants may be stilbenoids. Stilbenoids include resveratrol, pterostilbene, and piceatannol. Resveratrol can include, but is not limited to, 3,5,4'-trihydroxystilbene, 3,4,3',5'-tetrahydroxystilbene (piceatannol), 2,3',4,5'-tetrahydroxystilbene (oxyresveratrol), 4,4'-dihydroxystilbene, and alpha and beta glucosides, galactosides, and their mannoside derivatives.

The antioxidant may be coumarin (a derivative of 2H-chromen-2-one). Coumarins include 4-hydroxycoumarin, umbelliferone, esculetin, helinialin, auraptene and dicoumarol.

Antioxidants may be carotenoids. Carotenoids include beta-carotene, alpha-carotene, gamma-carotene, beta-cryptoxanthin, lycopene, lutein, and idebenone. Also, sesame (Sesamum indicum) or sesame lignans may be added. Sesame and its lignans (fibrous compounds related to sesame) act as antioxidants. Sesame seed lignans greatly enhance vitamin E activity.

Antioxidants include xanthone, butylated hydroxytoluene, 2,6-di-tert-butylphenol, 2,4-dimethyl-6-tert-butylphenol, gallic acid, eugenol, uric acid, alpha-lipoic acid, ellagic acid, chicolic acid, chlorogenic acid, rosmarinic acid, salicylic acid, acetylcysteine, S-allylcysteine, barbigerone, chebraginic acid, edaravone, ethoxyquin, glutathione, hydroxytyrosol, idebe non, melatonin, N-acetyl serotonin, nordihydroguaiaretic acid, oleocanthal, oroilopein, parador, piceatannol, probucol, propyl gallate, protocatechuic acid, pyritinol, rutin, secoisolariciresinol diglucoside, sesamin, sesamol, silibinin, silymarin, theaflavin, theaflavin digallate, thmoquinone ), trolox, tyrosol, polyunsaturated fatty acids, and sulfur-based antioxidants such as methionine or lipoic acid.

Chelating Agents Other Than Trisodium Ethylenediamine Disuccinate The cosmetic composition may optionally contain a chelating agent in addition to the trisodium ethylenediamine disuccinate described above. The amount of chelating agent other than tri-sodium ethylenediamine disuccinate present in the cosmetic composition includes ranges and subranges therebetween based on the total weight of the cosmetic composition, such as from about 0.1 wt% to about 10 wt%, from about 0.1 to about 8 wt%, from about 0.1 to about 6 wt%, from about 0.1 to about 5 wt%, from about 0.1 to about 4 wt%, from about 0.1 to about 3 wt%, from about 0.1 to about 2 wt%, about 0.1 to about 1 wt%; about 0.25 to about 10 wt%, about 0.25 to about 8 wt%, about 0.25 to about 6 wt%, about 0.25 to about 5 wt%, about 0.25 to about 4 wt%, about 0.25 to about 3 wt%, about 0.25 to about 2 wt%, about 0.25 to about 1 wt%; from about 6 wt%, from about 0.5 to about 5 wt%, from about 0.5 to about 4 wt%, from about 0.5 to about 3 wt%, from about 0.5 to about 2 wt%, from about 0.5 to about 1 wt%; about 0.75 to about 2 weight percent; about 1 to about 10 weight percent, about 1 to about 8 weight percent, about 1 to about 6 weight percent, about 1 to about 5 weight percent, about 1 to about 4 weight percent, about 1 to about 3 weight percent, or about 1 weight percent to about 2 weight percent.

化学キレート剤の非限定的な例としては、アミノトリメチルホスホン酸、β－アラニン二酢酸、クエン酸、シクロデキストリン、シクロヘキサンジアミン四酢酸、ジエチレントリアミンペンタメチレンホスホン酸、ジエタノールアミンＮ－酢酸、エチレンジアミン四酢酸（ＥＤＴＡまたはＹＨ _４ ）およびそのナトリウム塩（ＹＨ _３ Ｎａ、Ｙ _２ Ｈ _２ Ｎａ _２ 、ＹＨＮａ _３ 、およびＹＮａ _４ ）、カリウム塩（ＹＨ _３ Ｋ、Ｙ _２ Ｈ _３ Ｋ _３ 、およびＹＫ _４ ）、カルシウム二ナトリウム塩、ならびにジアンモニウム塩およびそのトリエタノールアミンとの塩（ＴＥＡ－ＥＤＴＡ）、エチドロン酸、ガラクタン酸（ｇａｌａｃｔａｎｉｃ ａｃｉｄ）、ヒドロキシエチルエチレンジアミン四酢酸（ＨＥＤＴＡ）およびその三ナトリウム塩、グルコン酸、グルクロン酸、ニトリロ三酢酸（ＮＴＡ）およびその三ナトリウム塩、ペンテト酸、フィチン酸、リボン酸、クエン酸ジアンモニウム、ジナトリウムアザシクロヘプタンジホスホネート、ジナトリウムピロホスエート（ｄｉｓｏｄｉｕｍ ｐｙｒｏｐｈｏｓｈａｔｅ）、ヒドロキシプロピルシクロデキストリン、メチルシクロデキストリン、三リン酸五カリウム、ペンタナトリウムアミノトリメチレンホスホネート、ペンタナトリウムエチレンジアミンテトラメチレンホスホネート、ペンテト酸五ナトリウム、三リン酸五ナトリウム、クエン酸カリウム、ＥＤＴＭＰカリウム、ＥＤＴＭＰナトリウム、ナトリウムキトサンメチレンホスホネート、ヘキサメタリン酸ナトリウム、メタリン酸ナトリウム、ポリリン酸カリウム、ポリリン酸ナトリウム、トリメタリン酸ナトリウム、ナトリウムジヒドロキシエチルグリシネート、グルコン酸カリウム、グルコン酸ナトリウム、グルコペプチン酸ナトリウム（ｓｏｄｉｕｍ ｇｌｕｃｏｐｅｐｔａｔｅ）、ナトリウムグリセレス－１ポリホスフェート、ピロリン酸四カリウム、トリエタノールアミンポリホスフェート（ＴＥＡ）、ピロリン酸四ナトリウム、リン酸三ナトリウム、カリウムトリホスホノメチルアミンオキシド、メタケイ酸ナトリウム、フィチン酸ナトリウム、ナトリウムポリジメチルグリシノフェノールスルホネート、テトラヒドロキシエチルエチレンジアミン、テトラヒドロキシプロピルエチレンジアミン、エチドロン酸四カリウム、エチドロン酸四ナトリウム、イミノジコハク酸四ナトリウム、トリナトリウムエチレンジアミンジスクシネート、エタノールアミンＮ，Ｎ－二酢酸、酢酸二ナトリウム、ジメルカプロール、デフェロキサミン、ジロックス（Ｚｙｌｏｘ）、ならびに／またはその全体がすべての目的のために本明細書に組み込まれる、国際特許出願ＷＯ第９４／６１３３８号に開示および請求されている鉄キレート剤が挙げられる。 Examples of biological chelating agents include metallothionein, transferrin, calmodulin, and sodium chitosan methylene phosphonate.

Nonionic Emulsifiers Other Than Polyglyceryl-3 Methyl Glucose Distearate In some cases, the cosmetic composition may include a nonionic emulsifier in addition to the polyglyceryl-3 methyl glucose distearate. The amount of nonionic emulsifier other than polyglyceryl-3 methylglucose distearate is from about 0.1% to about 20%, from about 0.1% to about 18%, from about 0.1% to about 16%, from about 0.1% to about 14%, from about 0.1% to about 12%, from about 0.1% to about 10%, from about 0.1% to about 8%, by weight, based on the total weight of the cosmetic composition, including all ranges and subranges therebetween. %, about 0.1 to about 7 wt%, about 0.1 to about 6 wt%, about 0.1 to about 5 wt%; It may be 0 wt%, about 4 to about 18 wt%, about 4 to about 16 wt%, about 4 to about 14 wt%, about 4 to about 12 wt%, about 4 to about 10 wt%, about 4 to about 8 wt%, or about 4 wt% to about 7 wt%.

Emulsifiers are typically used to incorporate oils and/or fatty compounds into hydrophilic media, such as aqueous media, to form oil-in-water emulsions. However, in some instances emulsifiers can be used to incorporate a hydrophilic phase (eg, an aqueous medium) into an oil or fatty phase to form a water-in-oil emulsion. Cosmetic compositions comprise one or more nonionic emulsifiers. However, additional emulsifiers can also be included (or excluded), such as amphoteric, anionic, and/or cationic emulsifiers.

In the case of O/W emulsions, examples of emulsifiers that may be mentioned include nonionic emulsifiers such as oxyalkylenated (more particularly polyoxyethylenated) fatty acid esters of glycerol; oxyalkylenated (more particularly polyoxyethylenated) fatty acid esters of sorbitan; oxyalkylenated (oxyethylenated and/or oxypropylenenated) fatty acid esters; A more exhaustive but non-limiting list of useful nonionic emulsifiers is provided below under the heading "Nonionic Emulsifiers".

In some cases, cosmetic compositions containing natural oils include two or more nonionic emulsifiers. In particular, one or more nonionic emulsifiers with an HLB of 10 or more and one or more nonionic emulsifiers with an HLB of 5 or less. The total amount of these emulsifiers can be such that the final HLB of the hair treatment composition is within +/−0.5 of the HLB of the natural oil in the cosmetic composition. This typically results in a final HLB of emulsified natural oils in hair treatment compositions ranging from about 6 to about 8.

Examples of emulsifiers that may be mentioned include nonionic emulsifiers such as oxyalkylenated (more particularly polyoxyethylenated) fatty acid esters of glycerol; oxyalkylenated fatty acid esters of sorbitan; oxyalkylenated (oxyethylenated and/or oxypropylenenated) fatty acid esters; oxyalkylenated (oxyethylenated and/or oxypropylenenated) fatty alcohol ethers; sugar esters such as sucrose stearate;

Non-limiting examples of nonionic emulsifiers include polyglyceryl emulsifiers, polyol esters, glycerol ethers, oxyethylenated ethers, oxypropylenated ethers, ethylene glycol polymers, sorbitan esters, polysorbates and mixtures thereof. In some examples, the one or more nonionic emulsifiers are selected from polyglyceryl 10-stearate, polyglyceryl-3-caprate, polyglyceryl-3-diisostearate, polyglyceryl-3-methylglucose distearate, or mixtures thereof.

pH Adjusting Agents The cosmetic composition may contain one or more pH adjusting agents to raise or lower the pH of the overall cosmetic composition. For example, one or more acids may be included to lower the pH of the cosmetic composition. Examples of suitable acids for lowering the pH of cosmetic compositions include, but are not limited to, citric acid, acetic acid, and the like. The cosmetic composition may contain one or more bases such as sodium hydroxide, potassium hydroxide, etc. to lower the pH of the cosmetic composition. Suitable additional or alternative acids and bases for adjusting the pH of cosmetic compositions are readily known to those skilled in the art.

The cosmetic composition desirably can have a pH of about 4 to about 7, preferably about 4.5 to about 6.5, or about 5.5 to about 6.5. In one example, the pH of the cosmetic composition is at or about 6. The amount of pH adjusting agent in the cosmetic composition can be based on the desired pH of the final cosmetic composition and/or product. For example, the total amount of pH modifiers may range from about 0.05% to about 20% by weight, based on the total weight of the composition. In some examples, the total amount of pH modifier is from about 0.05% to about 15%, from about 0.5% to about 10%, from about 1% to about 5%, from about 1.5% to about 4%, or from about 2.0% to about 3% by weight, including ranges and subranges therebetween, based on the total weight of the composition.

Water The total amount of water in the cosmetic composition can vary, but is typically from about 50% to about 95% by weight based on the total weight of the cosmetic composition. In some examples, the total amount of water is, based on the total weight of the cosmetic composition, about 50% to about 90%, about 50% to about 85%, about 50% to about 80%; about 55% to about 95%, about 55% to about 90%, about 55% to about 85%, about 55% to about 80%; , about 60 to about 85%, about 60 to about 80%; about 65 to about 95%, about 65 to about 90%, about 65 to about 85%, or about 65 to about 80%; about 70 to about 95%, about 70 to about 90%, about 70 to about 85%, about 70% to about 80%.

Methods of Manufacture The present disclosure also relates to methods or processes for making/manufacturing the cosmetic compositions described herein. It also includes products prepared by these methods or processes.

The process of making certain embodiments of the cosmetic composition involves forming an oil phase and a separate aqueous phase (containing water), heating both phases and combining them while warm. Each phase may be heated to the same temperature or may be heated to different temperatures.

Thickeners may be added to the aqueous phase of the cosmetic composition. However, in some instances, one or more emulsifiers and/or thickeners are added to the oil phase. Additionally or alternatively, a thickening agent may be added after emulsification, for example ammonium polyacryloydldimethyl taurate may be added after emulsification.

After combining the oil and aqueous phases to form an emulsion, the composition is typically cooled. Additional ingredients may be added at the time of emulsification or may be added after emulsification. For example, certain fragrances, colorants, dermatological agents, active ingredients, etc. may be added to the aqueous phase, the fatty phase, or may be added after emulsification.

Methods of Use The present disclosure also relates to methods of using the cosmetic compositions described herein. For example, the cosmetic composition can be used in a method comprising applying the cosmetic composition to human skin. In some cases, the composition is applied to the face. Additionally, the cosmetic composition can be used in methods of treating and/or repairing skin damage (e.g., photoaging damage), and reducing the appearance of skin wrinkles, age spots, and uneven skin texture. The methods described above are non-therapeutic.

The cosmetic composition can be applied once a day, twice a day, or more than once or twice a day. In some cases, the composition is applied at night before bed. In other cases the composition is applied in the morning. In still other cases, the composition may be applied immediately after cleansing the skin. The compositions may be used once or continuously over several days, weeks, or months. For example, the composition may be used daily for 1, 2, 3, 4, 5, 6, 7, 8 or more weeks, or for a period of several months.

Embodiments In certain embodiments, the cosmetic compositions of the present disclosure typically comprise
- from about 0.01% to about 3%, preferably from about 0.05% to about 2.5%; more preferably from about 0.1% to about 2% retinol;
- from about 0.01% to about 1%, preferably from about 0.01% to about 0.8%, more preferably from about 0.05% to about 0.8% by weight of tetra-di-t-butylhydroxyhydrocinnamate;
- about 0.01 wt% to about 3 wt%, preferably about 0.01 wt% to about 2.5 wt%; more preferably about 0.1 wt% to about 2 wt% trisodium ethylenediamine disuccinate;
- from about 0.5% to about 7%, preferably from about 0.75% to about 6%, more preferably from about 0.75% to about 5% by weight of polyglyceryl-3 methylglucose distearate;
- from about 0.9% to about 7%, preferably from about 1% to about 6%, more preferably from about 1% to about 5% by weight of sodium polyacrylate;
- from about 0.5% to about 8%, preferably from about 0.5% to about 6%, more preferably from about 1% to about 5% by weight silicone or coconut oil, soybean oil, canola oil, rape seed oil, corn oil, cottonseed oil, olive oil, palm oil, peanut oil, safflower oil, sesame oil, sunflower oil, linseed oil, palm kernel oil, tung oil, rapeseed oil, mustard oil, mustard oil, linseed oil. an oil phase comprising at least one of: , gumba shepherd's oil, castor oil, wheat germ oil, apricot kernel oil, pistachio oil, poppy oil, pine oil, avocado oil, hazelnut oil, grape seed oil, rapeseed oil, juniper oil, peach kernel oil, coffee bean oil, jojoba oil, or mixtures thereof; Containing 95% water by weight, the cosmetic composition is an oil-in-water emulsion and all weight percentages are based on the total weight of the cosmetic composition.

In a further embodiment,
(i) a cosmetic composition in the form of an oil-in-water emulsion,
- from about 0.01% to about 3%, preferably from about 0.05% to about 2.5%; more preferably from about 0.1% to about 2% retinol;
- from about 0.01% to about 1%, preferably from about 0.01% to about 0.8%, more preferably from about 0.05% to about 0.8% by weight of tetra-di-t-butylhydroxyhydrocinnamate;
- about 0.01 wt% to about 3 wt%, preferably about 0.01 wt% to about 2.5 wt%; more preferably about 0.1 wt% to about 2 wt% trisodium ethylenediamine disuccinate;
- from about 0.5% to about 7%, preferably from about 0.75% to about 6%, more preferably from about 0.75% to about 5% by weight of polyglyceryl-3 methylglucose distearate;
- from about 0.9% to about 7%, preferably from about 1% to about 6%, more preferably from about 1% to about 5% by weight of sodium polyacrylate;
- from about 0.5% to about 8%, preferably from about 0.5% to about 6%, more preferably from about 1% to about 5% by weight silicone or coconut oil, soybean oil, canola oil, rape seed oil, corn oil, cottonseed oil, olive oil, palm oil, peanut oil, safflower oil, sesame oil, sunflower oil, linseed oil, palm kernel oil, tung oil, rapeseed oil, mustard oil, mustard oil, linseed oil. an oil phase comprising at least one of: , gumba shepherd's oil, castor oil, wheat germ oil, apricot kernel oil, pistachio oil, poppy oil, pine oil, avocado oil, hazelnut oil, grape seed oil, rapeseed oil, juniper oil, peach kernel oil, coffee bean oil, jojoba oil, or mixtures thereof; A product is provided comprising a container containing a cosmetic composition, including a cosmetic composition comprising 95% by weight of water; and (ii) non-protective packaging, such as, for example, one without an aluminum layer and/or with a pump for dispensing the cosmetic composition.

In further embodiments, cosmetic compositions of the present disclosure typically comprise
- from about 0.01% to about 3%, preferably from about 0.05% to about 2.5%; more preferably from about 0.1% to about 2% retinol;
- from about 0.01% to about 1%, preferably from about 0.01% to about 0.8%, more preferably from about 0.05% to about 0.8% by weight of tetra-di-t-butylhydroxyhydrocinnamate;
- about 0.01 wt% to about 3 wt%, preferably about 0.01 wt% to about 2.5 wt%; more preferably about 0.1 wt% to about 2 wt% trisodium ethylenediamine disuccinate;
- from about 0.5% to about 7%, preferably from about 0.75% to about 6%, more preferably from about 0.75% to about 5% by weight of polyglyceryl-3 methylglucose distearate;
- from about 0.9% to about 7%, preferably from about 1% to about 6%, more preferably from about 1% to about 5% by weight of sodium polyacrylate;
- from about 0.5% to about 8%, preferably from about 0.5% to about 6%, more preferably from about 1% to about 5% by weight silicone or coconut oil, soybean oil, canola oil, rape seed oil, corn oil, cottonseed oil, olive oil, palm oil, peanut oil, safflower oil, sesame oil, sunflower oil, linseed oil, palm kernel oil, tung oil, rapeseed oil, mustard oil, mustard oil, linseed oil. An oil phase comprising at least one of: , Gumbiana oil, castor oil, wheat germ oil, apricot kernel oil, pistachio oil, poppy oil, pine oil, avocado oil, hazelnut oil, grape seed oil, rapeseed oil, juniper oil, peach kernel oil, coffee bean oil, jojoba oil, or mixtures thereof;
- water, preferably from about 50% to about 95% water, more preferably from about 60% to about 95% water;
- optionally from about 0.05% to about 5% by weight, preferably from about 0.05% to about 4%, more preferably from about 0.05% to about 3% by weight of a thickening agent that is not sodium polyacrylate, such as ammonium polyacryloyldimethyltaurate, ammonium acryloyldimethyltaurate/VP copolymer, sodium polyacrylate, acrylate copolymer, polyacrylamide, carbomer, acrylate/C10-30 alkyl acrylate crosspolymer; selected from acrylates/beheneth-25 methacrylate copolymers and mixtures thereof;
- optionally from about 0.1% to about 10%, preferably from about 0.25% to about 8%, more preferably from about 0.5% to about 6% by weight of a matting agent, such as aluminum starch octenyl succinate;
- optionally from about 1% to about 30%, preferably from about 5% to about 25%, more preferably from about 10% to about 20% by weight of a polyol such as ethylene glycol, propylene glycol, butylene glycol, hexylene glycol, pentylene glycol, diethylene glycol, dipropylene glycol, caprylyl glycol, 1,3 propanediol, glycerin, diglycerin, polyethylene glycol or mixtures thereof;
- optionally a skin active agent in an amount up to about 5% by weight, preferably from about 0.05% to about 5%, more preferably from about 0.1% to about 4% by weight, such as hyaluronic acid, lanolin, niacinamide, citric acid, malic acid, lactic acid, tartaric acid, salicylic acid, capryloyl salicylic acid, retinoids, retinal, retinol, adenosine, sodium hyaluronate, retinoic acid, carotenoids, bread The cosmetic composition is an oil-in-water emulsion consisting of tenols, amino acids, proteins, enzymes, coenzymes, and mixtures thereof, and all weight percentages are based on the total weight of the cosmetic composition.

The following examples are provided primarily for the purpose of demonstrating the benefits achieved by embodiments of the present disclosure. The examples serve to illustrate the technology and are not necessarily limiting at all.

Example 2
Example Composition A and eight commercial benchmarks (Commercial Benchmarks BI) were placed in opaque containers and stored in a controlled environment chamber to determine retinol stability over a period of eight weeks. The controlled environment chamber was set at a temperature of 45°C. Example Composition A was stored in a container that dispenses the composition using a standard pump (stored in a container with a removable top with a standard cosmetic pump). The eight commercial benchmark containers and the amount of residual retinol are shown in the table below.

Example Composition A and Commercial Benchmarks BI were evaluated for residual retinol content after storage using high performance liquid chromatography. High-performance liquid chromatography was performed using a Kinetex XB C-18 column with a mobile phase of 25% methanol and 75% ACN at a flow rate of 2 mL/min and a temperature of 45°C. The detector was a UV/Vis detector. The high performance liquid chromatograph evaluated 10 μL of sample at scanning wavelengths from 250 nm to 400 nm during a 6 minute scan run.

The term "INCI" stands for International Nomenclature of Cosmetic Ingredients, defined by the International Nomenclature Committee of the Personal Care Products Council, A system of names for personal care ingredients.

All ranges provided herein are meant to include all specified ranges within a given range, as well as combinations of subranges between the given ranges. Thus, the range from 1 to 5 specifically includes subranges from 2 to 5, 3 to 5, 2 to 3, 2 to 4, 1 to 4, etc., as well as 1, 2, 3, 4, and 5 specifically.

All components and elements positively described in this disclosure may be negatively excluded from the claims. In other words, the cosmetic compositions of the present disclosure may be free or essentially free of all ingredients and elements actively referred to throughout this disclosure.

In some examples, the cosmetic compositions of the present disclosure may be substantially free of non-incidental amounts of ingredients or compounds described herein. A non-incidental amount of an ingredient or compound is the amount of that ingredient or compound added alone to the cosmetic composition. For example, a cosmetic composition may be substantially free of non-incidental amounts of an ingredient or compound, although such ingredients or compounds may be present as part of an ingredient that includes such ingredients or compounds as a blend of two or more compounds.

Some of the various categories of ingredients identified may overlap. Thus, there may be overlap, and where a composition contains both ingredients (or where a composition contains more than two overlapping ingredients), the overlapping compounds do not represent more than one ingredient. For example, tocopherols can be characterized as both skin active agents and preservatives. If a particular composition contains both a skin active agent and a preservative, steareth-20 functions only as a skin active agent or only as a preservative (tocopherol does not function as both a skin active agent and preservative).

All publications and patent applications cited in this specification are herein incorporated by reference for any and all purposes as if each individual publication or patent application was specifically and individually indicated to be incorporated by reference. In the event of any conflict between this disclosure and any publication or patent application incorporated herein by reference, the present disclosure will control.

As used herein, the terms "comprising," "having," and "including" are used in their open, non-limiting senses.

The terms "a", "an" and "the" are understood to include the plural as well as the singular. The term "a mixture there of" therefore also relates to "mixtures there of". Throughout this disclosure, the term "mixtures thereof" is used following a listing of elements, as shown in the following examples where the letters A through F represent the elements: "one or more elements selected from the group consisting of A, B, C, D, E, F, and mixtures thereof." The term "mixture thereof" does not require that the mixture contain all of A, B, C, D, E, and F (although it may contain all of A, B, C, D, E, and F). Rather, it indicates that mixtures of any two or more of A, B, C, D, E, and F can be included. In other words, it is equivalent to the phrase "one or more elements selected from the group consisting of A, B, C, D, E, F, and mixtures of any two or more of A, B, C, D, E, and F."

The phrase "one or more" means "at least one" and thus includes mixtures/combinations as well as individual components.

Except in the working examples, or unless otherwise indicated, all numbers expressing amounts of ingredients and/or reaction conditions can be modified by the term "about" to mean within +/- 5% of the indicated number in all instances.

As used herein, the term "treating" (and grammatical variations thereof) refers to applying the compositions of the present disclosure to the surface of a keratinous substrate, such as hair on the head and/or body of a user.

As used herein, the terms "substantially free" or "essentially free" mean that there is less than about 2% by weight of a particular material added to the composition, based on the total weight of the composition. Nevertheless, the composition may contain less than about 1% by weight, less than about 0.5% by weight, less than about 0.1% by weight, or no specific material at all. All components described herein may optionally be included or excluded from the compositions/methods/kits. If excluded, the composition/method/kit may be free or essentially free of that component. For example, certain compositions may be free or essentially free of silicones.

Claims (20)

(a) from about 0.01% to about 3% by weight retinol;
(b) from about 0.01% to about 1% by weight of tetra-di-t-butylhydroxyhydrocinnamate;
(c) from about 0.01% to about 3% by weight trisodium ethylenediamine disuccinate;
(d) from about 0.5% to about 7% by weight of polyglyceryl-3 methylglucose distearate;
(e) from about 0.9% to about 7% by weight sodium polyacrylate;
(f) from about 0.5% to about 8% by weight of an oil phase; and (g) a cosmetic composition comprising water, wherein the cosmetic composition is an oil-in-water emulsion, all weight percentages being based on the total weight of the cosmetic composition. A cosmetic composition according to claim 1, wherein the oil phase comprises silicone. The oil phase consists of coconut oil, soybean oil, canola oil, rapeseed oil, corn oil, cottonseed oil, olive oil, palm oil, peanut oil, safflower oil, sesame oil, sunflower oil, linseed oil, palm kernel oil, tung oil, arachis oil, mustard oil, linseed oil, gumba shepherd's oil, castor oil, wheat germ oil, apricot kernel oil, pistachio oil, poppy oil, pine oil, 2. The cosmetic composition of claim 1, comprising avocado oil, hazelnut oil, grape seed oil, rapeseed oil, juniper oil, peach kernel oil, coffee bean oil, jojoba oil, or mixtures thereof. A cosmetic composition according to any one of claims 1 to 3, wherein the oil phase comprises a fatty acid ester that is not polyglyceryl-3-methylglucose distearate. 5. The cosmetic composition according to claim 4, wherein the fatty acid ester is selected from isononyl isononanoate, caprylic/capric triglyceride, and mixtures thereof. The cosmetic composition of claim 1, further comprising (h) from about 0.05% to about 5% by weight of a thickening agent that is not sodium polyacrylate. 4. The cosmetic composition according to any one of claims 1 to 3, wherein the weight ratio of the total amount of trisodium ethylenediamine disuccinate to the total amount of sodium polyacrylate is from about 1:1 to about 1:5. 4. The cosmetic composition of any one of claims 1-3, further comprising (i) from about 0.1% to about 10% by weight of a matting agent. 9. A cosmetic composition according to claim 8, wherein the matting agent comprises aluminum starch octenyl succinate. 4. The cosmetic composition of any one of claims 1-3, further comprising (j) from about 1% to about 30% by weight of a polyol. 11. The cosmetic composition of Claim 10, wherein the polyol is selected from ethylene glycol, propylene glycol, butylene glycol, hexylene glycol, pentylene glycol, diethylene glycol, dipropylene glycol, caprylyl glycol, 1,3 propanediol, glycerin, diglycerin, polyethylene glycol, and mixtures thereof. 4. The cosmetic composition of any one of claims 1-3, further comprising (k) from about 0.05% to about 5% by weight of a skin active agent. 13. The cosmetic composition of Claim 12, wherein the active agent is selected from hyaluronic acid, niacinamide, lanolin, citric acid, malic acid, lactic acid, tartaric acid, salicylic acid, capryloylsalicylic acid, retinoids, retinal, retinol, adenosine, sodium hyaluronate, retinoic acid, carotenoids, panthenol, amino acids, proteins, enzymes, coenzymes, and mixtures thereof. 4. The cosmetic composition according to any one of claims 1 to 3, which is tocopherol-free. 4. The cosmetic composition according to any one of claims 1 to 3, which is free of ascorbyl palmitate. (I) a cosmetic composition in the form of an oil-in-water emulsion comprising:
(a) from about 0.01% to about 3% by weight retinol;
(b) from about 0.01% to about 1% by weight of tetra-di-t-butylhydroxyhydrocinnamate;
(c) from about 0.01% to about 3% by weight of trisodium ethylenediamine disuccinate;
(d) from about 0.5% to about 7% by weight of polyglyceryl-3 methylglucose distearate;
(e) from about 0.9% to about 7% by weight sodium polyacrylate;
(f) from about 0.5% to about 8% by weight of an oil phase; and (g) a cosmetic composition comprising water, all weight percentages being based on the total weight of the cosmetic composition, and (II) a container containing the cosmetic composition. 17. Cosmetic product according to claim 16, wherein the container does not contain an aluminum layer. 18. Cosmetic product according to claim 16 or 17, wherein the composition does not phase separate and retains at least 85% by weight of retinol after storage at 45[deg.]C for 8 weeks. 18. Cosmetic product according to claim 16 or 17, wherein the composition does not turn yellow after storage at 45[deg.]C for 8 weeks. (a) from about 0.01% to about 3% by weight retinol;
(b) from about 0.01% to about 1% by weight of tetra-di-t-butylhydroxyhydrocinnamate;
(c) from about 0.01% to about 3% by weight of trisodium ethylenediamine disuccinate;
(d) from about 0.5% to about 7% by weight of polyglyceryl-3 methylglucose distearate;
(e) from about 0.9% to about 7% by weight sodium polyacrylate;
(f) from about 0.5% to about 8% by weight of an oil phase;
(g) water;
(h) optionally from about 0.05% to about 5% by weight of a thickening agent that is not sodium polyacrylate;
(i) optionally from about 0.1% to about 10% by weight of a matting agent;
(j) optionally from about 1% to about 30% by weight polyol; and (k) optionally a skin active agent in an amount up to about 5% by weight, comprising:
A cosmetic composition that is an oil-in-water emulsion and all weight percentages are based on the total weight of the cosmetic composition.