JP2001522787A - Composition containing both liquid polyol fatty acid polyester and liquid oil - Google Patents

Abstract

  (57) [Summary] (a) a melting point of about −30 ° C. to about 30 ° C., one polyol moiety and one or more fatty acid moieties, and the polyol moiety has four or more free hydroxyl groups, of which 60% or more From about 0.1 to about 99.9% by weight of a liquid polyol fatty acid polyester esterified with a fatty acid moiety having one or more 8 to 22 carbon atoms, and (b) a melting point of from about -30C to about 30C. Less than 30 ° C. and blends of liquid polyol fatty acid polyesters, isohexadecane, isopropyl-palmitate, or C13-C14 isoparaffins, and is substantially free of polyacrylamide and laureth-7, from about 0.1 to about 99.9. Disclosed are compositions suitable for topical application to human hair and skin, comprising weight percent liquid oil. The composition preferably further includes a topical carrier for compounding the liquid polyol fatty acid polyester and the liquid oil. This composition has a skin softening and cosmetic effect.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001] Technical Field The present invention specific liquid in the range melting point and specific liquid polyol fatty acid polyesters in the range of about -30 ° C. to about 30 ° C., a melting point of about -30 ° C. of less than about 30 ° C. Compositions suitable for topical application to human hair and skin, comprising oils.

[0002] Topical compositions containing the background art emollients have been used for many years in the treatment of human hair and skin. For example, occlusive hydrocarbons such as petrolatum have been used as topical emollients to form a protective film on the skin to prevent the loss of moisture to the surroundings. Petrolatum has also been used in hair care products as a conditioner and hairdressing aid.

However, the most effective and widely used compositions containing occlusive softeners have a greasy, greasy feel, which is a cosmetic drawback. Moreover, some of the occlusive softeners that have been used to form a protective film on the skin are those that block pores in the skin and impede oxygen flow. When the surface of the skin is blocked or the flow of air or moisture is hindered, the use of such a sticky occlusive softener is limited. In addition, European Patent No. 45 issued March 2, 1994
No. 8,600 B1, occluding properties include liquid polyol fatty acid polyesters having four or more free hydroxyl groups, at least 60% of which are esterified with one or more fatty acids having 8 to 22 carbon atoms. A skin care composition is disclosed. When this liquid polyol fatty acid polyester is applied topically to the skin, an occlusion film is formed on the skin. Macaulay et al., US Pat. No. 5,16, issued Nov. 3, 1992
No. 0,738 discloses an occlusive composition comprising a blend of two or more polyol fatty acid polyesters. This blend has petrolatum-like appearance and physical properties. However, these compositions also have the disadvantage of sticky, blocking pores in the skin and impeding oxygen flow. Therefore, there is a need for a substance that softens the skin, is not sticky, has no occlusion properties, and is also cosmetically satisfactory.

[0004] It has been found that compositions containing non-occlusive emollients can be formulated to a composition that does not feel sticky, sticky, or greasy. These compositions include a specific set of liquid polyol fatty acid polyesters having a melting point in the range of about -30C to about 30C and liquid oils having a melting point in the range of about -30C to less than about 30C. Matching is included. This liquid oil includes liquid polyol fatty acid polyesters,
Blends of isohexadecane, isopropyl-palmitate, or C13-C14 isoparaffins, and little polyacrylamide or laureth-7. These compositions can be applied to various products that provide both emollient and cosmetic effects.

[0005] Accordingly, it is an object of the present invention to provide a composition that softens the skin, satisfies cosmetic effects, and contains a non-storing softener used in combination with a specific liquid oil. . It is a further object of the present invention to provide a topical composition comprising polyol fatty acid polyesters which does not have a sticky, sticky or greasy feel and is effective in treating human hair and skin. It is.

SUMMARY OF THE INVENTION The present invention relates to (a) a polymer having a melting point of about -30 ° C to about 30 ° C, one polyol moiety and one or more fatty acid moiety, and the polyol moiety has four or more free hydroxyl groups. From about 0.1 to about 99.9% by weight of a liquid polyol fatty acid polyester, wherein at least about 60% are esterified with at least one fatty acid moiety having from 8 to 22 carbon atoms, and b) a blend of liquid polyol fatty acid polyesters, isohexadecane, isopropyl-palmitate, or C13-C14 isoparaffins and polyacrylamide, having a melting point of about -30 ° C to less than about 30 ° C;
Laureth-7 relates to a composition suitable for topical application to human hair or skin, comprising from about 0.1 to about 99.9% by weight of a liquid oil, substantially free of laureth-7. This composition includes:
Preferably, the composition further comprises a topical carrier for blending the liquid polyol fatty acid polyester and the liquid oil.

[0007] All percentages and ratios used herein are by weight, unless otherwise specified, and all measurements are made at 25 ° C. The invention of this specification includes the essential components and the optional components and elements mentioned in this specification (compris
e) consist essentially of and consist of.

[0008] The term is used in the detailed description herein of the invention "topical composition" means a composition suitable for topical application to human hair or skin. The term is used to encompass a wide variety of body care compositions, beauty care compositions, and cosmetic compositions. Non-limiting examples of topical compositions include lotions, creams, hand and body lotions, skin conditioning lotions and creams, skin protection compositions, sunscreen compositions, cold creams, acne. Anti-static compositions, skin renewal products, non-foaming cleaning lotions, moisturizers, facial moisturizers, makeup, foundations, lipsticks, lip protectants, skin cleansers,
Hand washing, face washing, body washing, shower products, shampoo, etc.

As used herein, the term “topical carrier” is a term well known to those skilled in the art, and includes one or more compatible solid or liquid filler diluents suitable for human use. Agent or vehicle. As used herein, the term "affinity" refers to a component of a topical carrier that does not interact under normal conditions of use to substantially reduce the efficacy or aesthetic effect of a cosmetic composition. , Or with the components of the present invention. The topical carrier must be a pharmaceutically acceptable carrier. As used herein, the term "pharmaceutically acceptable" refers to a topical carrier of sufficient purity and toxicity.
It means that it is suitable for use in contact with human hair and skin without severe affinities, instability and allergic reactions.

As used herein, unless otherwise specified, the term “liquid” refers to a substance that is a fluid that is fluid under ambient conditions of atmospheric pressure, about 50% relative humidity, and about 20 to about 25 ° C. Pointing to.

As used herein, the term “specific liquid oil” refers to a blend of liquid polyol fatty acid polyesters, isohexadecane, isopropyl-palmitate, or C 13 -C 14 isoparaffins having a melting point of less than about 30 ° C. And polyacrylamide and laureth-7 are liquid oils that are almost free. In this context, the term "substantially free" refers to the fact that these compositions, when used in combination with liquid polyol fatty acid polyesters, to obtain emollient and cosmetic benefits, exclude such substances. It means that the content is less than the effective amount.
Generally, these compositions will be less than 1%, preferably less than 0.5%, more preferably less than 0.25%, even more preferably less than 0.1% by weight of the composition. , And most preferably zero percent of such excluded substances.

[0012] The melting points of the liquid polyol fatty acid polyesters and the liquid oil can be measured using an ordinary method. This type of method is clearly defined in the art, and includes a method of measuring temperature and a method of using a calorimeter. A particularly suitable method for determining melting points is described in Letton, April 26, 1994, which is one of the references in this specification.
No. 5,306,514. In this method, a melting point is measured at a scanning temperature of 5 ° C./min using a differential scanning calorimeter (DSC). Melting point is the temperature at which the baseline (unusual heat line) intersects the line tangent to the end of the endothermic peak.

Liquid Polyol Fatty Acid Polyester The composition of the present invention comprises from about 0.1% to about 99.9%, preferably from about 0% by weight of the composition.
The non-storable liquid polyol fatty acid polyester is included at a concentration in the range of about 0.5 to about 75%, more preferably about 1 to about 50%, and even more preferably about 2 to about 25%. These liquid polyol fatty acid polyesters have a melting point of less than about 30 ° C. and have four or more free hydroxyl groups, of which at least 60% are comprised of one or more fatty acid moieties having 8 to 22 carbon atoms. It is derived from an esterified, aliphatic or aromatic polyol. These fatty acids are termed "
Since "carboxylic acid" and "fatty acid" are often used interchangeably by those skilled in the art, they are also called carboxylic acids.

The preferred liquid polyol-polyesters used in the present invention include certain polyols, especially sugars or sugar alcohols esterified with at least one fatty acid group. Therefore, the polyol starting material must have at least four esterifiable hydroxyl groups. Examples of suitable polyols include sugars, including monosaccharides and disaccharides, and sugar alcohols. Examples of monosaccharides containing four hydroxyl groups are xylose and sugar alcohols with five hydroxyl groups derived from arabinose and xylose, ie xylitol. Erythrose, a monosaccharide, is not suitable for carrying out the present invention because it has only three hydroxyl groups, but sugar alcohol derived from erythrose,
That is, erythritol can be used because it has four hydroxyl groups. Suitable monosaccharides containing five hydroxyl groups are galactose, fructose, and sorbose. Sucrose and sugar alcohols containing six OH groups derived from the hydrolysis products of glucose and sorbose, such as sorbitol, are also suitable. Examples of disaccharide polyols that can be used include maltose, lactose and sucrose, which contain eight hydroxyl groups.

[0015] The polyols used in the liquid polyol esters of the present invention include about 4
There are from about 12 to more preferably about 4 to about 11, and most preferably about 4 to about 8 hydroxyl groups. Polyols suitable for producing polyesters in the present invention are selected from the group consisting of erythritol, xylitol, sorbitol, glucose and sucrose. Sucrose is particularly preferred.

Preferred polyol starting materials having four or more hydroxyl groups are esterified with fatty acids in which at least 60% of the hydroxyl groups have about 8 to about 22, preferably about 8 to about 18 carbon atoms. There must be. Examples of this type of fatty acid include caprylic, capric, lauric, myristic, myristoleic, palmitic,
Palmitoleic acid, stearic acid, oleic acid, ricinoleic acid, linoleic acid, linolenic acid, eleostearic acid, arachiic acid, arachidonic acid, behenic acid,
And erucic acid. Fatty acids can be derived from natural or synthetic fatty acids. These fatty acids may be saturated or unsaturated, including positional and geometric isomers. However, to obtain liquid polyesters suitable for use in the present invention, at least about 50% by weight of the fatty acids incorporated into the polyester molecules must be unsaturated fatty acids. Oleic and linoleic acids and their mixtures are particularly preferred.

The polyol fatty acid polyesters useful in the present invention must contain one or more fatty acid ester groups. Not all hydroxyl groups of the polyol need be esterified, but preferably at least 60% of the hydroxyl groups are esterified with fatty acid ester groups. Most preferably, almost all of the hydroxyl groups of the polyol are esterified with fatty acids, ie, the polyol portion is almost completely esterified. The fatty acids that esterify the polyol molecule can be the same or a mixture, but as noted above, a significant amount of unsaturated acid ester groups must be present in order to obtain a liquid product.

To illustrate the above, sucrose fatty acid diesters should be suitable for use herein, but are not preferred because they have more than one unesterified hydroxyl group. Similarly, sucrose tetrafatty acid esters appear to be suitable, but are not preferred due to the presence of two or more unesterified hydroxyl groups. Highly preferred compounds in which all hydroxyl groups are esterified with fatty acids include liquid sucrose octa-substituted fatty acid esters.

Non-limiting examples of specific polyol fatty acid polyesters containing one or more fatty acid ester groups suitable for use in the present invention include glucose-oleate, glucose of soybean oil fatty acid (unsaturated). -Ester, mixed soybean oil fatty acid mannose-
Esters, Galactose of Oleic Acid-Arabinose of Linoleic Acid-
Esters, xylose-linoleate, sorbitol-oleate, sucrose-oleate, glucose-dioleate, glucose-diesters of soybean fatty acid (unsaturated), mannose-diesters of mixed soybean fatty acid, galactose-diesters of oleic acid , Arabinose-diesters of linoleic acid, xylose-dilinoleate, sorbitol-dioleate, sucrose-dioleate, glucose-dioleate, glucose-trioleate, soybean oil fatty acid (unsaturated)
Glucose-triesters, mixed soybean oil mannose-triesters, oleic acid galactose-triesters, linoleic acid arabinose-triesters, xylose-trilinolate, sorbitol-trioleate, sucrose-trioleate, soybean oil Glucose-tetraesters of fatty acids (unsaturated), mannose-tetraesters of mixed soybean oil fatty acids, galactose-tetraesters of oleic acid, arabinose-tetraesters of linoleic acid, xylose-tetralinolate, sorbitol- Tetraoleate, galactose-pentaoleate, sorbitol-hexaesters of unsaturated soybean oil fatty acids, xylitol-pentaoleate, sucrose-tetraoleate, sucrose-pentaoleate, sucrose -Hexaoleate, sucrose-heptaoleate, sucrose-octaoleate, and mixtures thereof. Liquid polyol esters selected from sucrose-pentaoleate, sucrose-hexaoleate, sucrose-heptaoleate, sucrose-octaoleate, and mixtures thereof are preferred. More preferred are sucrose-hexaoleate, sucrose-heptaoleate, sucrose-octaoleate, and mixtures thereof.

[0020] Preferred liquid polyol polyesters of the present invention have a melting point of about -30 to about 30 ° C.
, Preferably from about -30 to about 27.5 ° C, more preferably from about -30 to about 25 ° C. Melting points are determined by conventional methods.

[0021] The polyol fatty acid polyesters suitable for use herein can be prepared by various methods well known to those skilled in the art. These methods include transesterification of polyols with methyl, ethyl or glycerol fatty acid esters using various catalysts, acylation of polyols with fatty acid chlorides, acylation of polyols with fatty acid anhydrides, and polyols with fatty acids themselves. Acylation. U.S. Patent No. 2,831,854, Jandace, issued January 25, 1977.
k, U.S. Pat. No. 4,005,196, issued Jan. 25, 1977 to Jandacek, U.S. Pat.
See 4,005,196. These patents are part of the references in this specification.

Liquid Oil The compositions of the present invention include a specific liquid oil as defined herein for use in conjunction with the liquid polyol fatty acid polyesters described herein. The concentration of a particular liquid oil is from about 0.1 to about 99.9%, preferably from about 0.5 to about 75%, more preferably from about 1 to about 50%, by weight of the composition, and Even more preferably, it is in the range of about 2 to about 25%.

The liquid oils useful herein are substantially free of liquid polyol fatty acid polyesters, blends of isohexadecane, isopropyl-palmitate, or C13-C14 isoparaffins and polyacrylamide or laureth-7; And a melting point of less than about 30C, preferably from about -30C to less than about 30C, more preferably from about -30 to about 27.5C, and even more preferably from about -30 to about 25C. Some kind of oil. The solubility of these liquid oils in water is generally low, less than about 1% by weight at 25 ° C. Examples of suitable liquid oils include mineral oils, hydrocarbons having about 5 to about 16 carbon atoms, aliphatic alcohol esters having about 3 to about 22 carbon atoms, about 3 to about 30 carbon atoms. These include, but are not limited to, fatty acid esters having carbon atoms, vegetable oils, and mixtures thereof. Liquid oils suitable for use herein are, in addition, one of the references of this specification, 19
WO 95-00166, Gordon et al., Issued January 5, 1995.

[0024] Mineral oil, also known as petrolatum liquid, is suitable for use herein. It is a mixture of liquid hydrocarbons obtained from petroleum. Merck Inde
x, 10th edition, Entry 7048, p. 1033 (1983) and International Cosmetic Ingred
See the English Dictionary, 5th Edition, vol. 1, p. 415-417 (1993). These are some of the references in this specification.

Examples of certain hydrocarbon liquid oils suitable for use herein include straight and branched chain hydrocarbons having about 5 to about 16 carbon atoms. Non-limiting examples of these hydrocarbons include dodecane, isododecane, hydrogenated polyisobutylene, and hexadecane. C5-C16 isoparaffins, other than C13-C14 isoparaffins, are also useful. C13-C14 isoparaffins can be used in combination with polyacrylamide or laureth-7. These C5-C16 isoparaffins are also called C5-C16 branched hydrocarbons.

The aliphatic alcohol esters suitable for use as the particular liquid oils defined herein include esters and diesters of aliphatic alcohols having about 3 to about 22 carbon atoms. is there. Also useful are fatty acid esters having about 3 to about 28 carbon atoms. Non-limiting examples of these esters include isopropyl-myristate, isopropyl-stearate, diisopropyl-adipate, and dioctyl-sebacate (the dioctyl ester of decanedioic acid).

Certain liquid oils suitable for use herein include, among others, about 20 to about 25
Some vegetable oils are liquid at ambient temperatures of ° C. Examples of suitable vegetable oils include cod liver oil, dolphin oil, lard oil, beef foot oil, rat porpoise oil, seal oil, sperm whale oil, whale oil, acorn oil, almond oil, beech seed oil, large flour oil, rapeseed oil, Soybean oil, sunflower seed oil, American thigh oil, cottonseed oil, corn oil, safflower oil, olive oil, herring oil, sesame oil, castor oil, hazelnut oil, hemp seed oil, linseed oil, mustard (black) oil, neem oil, peanut oil Oil, pistachio nut oil, poppy seed oil, pumpkin seed oil, tung oil, white pepper seed oil, pine oil, wheat malt oil, their derivatives and mixtures thereof.

Topical Carrier The compositions of the present invention comprise, by weight, from about 0.1 to about 99, by weight, for incorporation of the liquid polyol fatty acid polyester and liquid oil, and for all other optional ingredients of the present invention. .9, preferably from about 50 to about 99%, more preferably from about 60 to about 95%, of the topical carrier.

The blend of the liquid polyol fatty acid polyester and the liquid oil of the present invention includes creams, lotions, milks, gels, hand and body lotions, cold creams, non-foaming cleaning lotions, For a wide variety of products including facial moisturizers, sunscreens, anti-acne preparations, topical analgesics, mascaras, lipsticks, skin cleansers, hand cleansers, face cleansers, body cleansers, shower products, shampoos, etc. Can be prescribed. Carriers and the additional components required in the formulation of such products vary with product type and are routinely selected by those skilled in the art.

The topical carrier can take a wide variety of forms. For example, emulsion carriers that include water-in-oil, oil-in-water, water-in-oil-in-water, and silicone-in-oil-in-water emulsions are useful herein. These emulsions can cover a wide range of viscosities, for example, from about 100 to about 200,000 cps. Suitable topical carriers include other liquid anhydrous solvents such as alcohols and silicones (eg, ethanol, isopropanol, dimethicone, cyclomethicone, etc.)
Aqueous single phase liquid solvents (eg, hydro-alcohol solvent systems); and thickening types of these anhydrous and aqueous single phase solvents (eg, suitable rubbers, resins, waxes, polymers, Addition of salts, etc. increases the viscosity of the solvent to form a solid or semi-solid). Examples of topical carrier systems useful in the present invention are described in the following references, which are part of the references of this specification. In other words, Cosm etics & Toiletries, vol. 105, pp. 122-139 paper published in the (December 1990) "
Sun Products Formulary '', Cosmetics & Toiletries , vol. 102, pp. 117-136
(Mar. 1987), "Sun Products Formulary," U.S. Pat. No. 4,960,764 to FIG. 2, issued on Oct. 2, 1990, and F. issued on Mar. 3, 1981.
Ukuda et al., U.S. Pat.No. 4,254,105; Orr et al., U.S. Pat.No. 4,976,953, issued Dec. 11, 1990; Turner et al., U.S. Pat.No. 5,073,372, issued Dec. 17, 1991.
No. 5,585,104 issued on December 17, 1996, Moore et al., US Pat. No. 5,607,678 issued Mar. 4, 1997, issued Mar. 4, 1997.
U.S. Patent No. 5,607,980 to McAtee et al. And U.S. Patent No. 5,618,522 to Kaleta et al. Issued April 8, 1997.

Topical carriers also include oil-in-water emulsion systems having complex structures such as liquid crystals and crystalline gel networks. For the properties of liquid crystals, the formation of liquid crystals, and the properties and advantages of liquid crystals, see G. Dahms's paper "O / E with anisotropic lamellar phase" published in Cosmetics & Toiletries, vol. 101, 113-115 (1986). Properties of Emulsions ", P. Loll's paper" Liquid Crystals in Cosmetic Emulsions ", published in ICI Surfactants ^, Publication RP94-93E, and J. Soc. Cosmet. Chem., Vol.
41, 1-22 (January 1990) in GM Eccleston's dissertation "Multiphasic water-in-oil emulsions". These articles are part of the references of this specification.

Additional Ingredients A wide variety of additional ingredients can be added to the compositions herein. Non-limiting examples include:

Pharmaceutical Actives The compositions of the present invention can include a safe and effective amount of a pharmaceutically active substance. As used herein, a "safe and effective amount" is active enough to significantly or positively ameliorate the condition to be treated, but with severe side effects (reasonable (E.g., at an effective effect / risk ratio). A safe and effective amount of a pharmaceutically active substance is determined by the individual active substance, the ability of the composition to penetrate the active substance through the skin, the amount of composition administered, the condition of the individual patient being treated, the age of the patient, It varies with factors such as physical condition, severity of condition, duration of treatment, characteristics of combination therapy, and the like.

[0034] The compositions of the present invention preferably comprise from about 0.1 to about 20%, more preferably from about 0.1 to about 10%, and most preferably from about 0 to about 10% by weight of the composition. .1 to about 5% pharmaceutically active substance. Mixtures of pharmaceutically active substances can also be used.

Non-limiting examples of pharmaceutically active substances include: That is, pharmaceutically active substances useful in the compositions of the present invention include anti-acne agents. The anti-acne agents used in this specification include keratolytic agents such as salicylic acid, sulfur, lactic acid, glycolic acid, pyruvate, resorcinol, and N-acetylcysteine; retinoic acid and its derivatives (eg, cis and trans) Retinoids such as benzoyl peroxide, octopirox, erythromycin, zinc, tetracycline, triclosan, azelaic acid and its derivatives, phenoxyethanol and phenoxypropanol, ethyl acetate, clindamycin and meclocycline; There are sebostats such as flavinoids; alpha and beta hydroxy acids, and bile salts such as simanol sulfate and its derivatives, deoxycholate and cholate. Preferred anti-acne actives are salicylic acid,
It is selected from sulfur, resorcinol, lactic acid, zinc, erythromycin, benzoyl peroxide, and mixtures thereof. More preferred is salicylic acid.

[0036] Pharmaceutically active agents useful in the compositions of the present invention include non-steroidal anti-inflammatory drugs (NSAIDS). NSAIDS can be selected from propionic acid derivatives, acetic acid derivatives, phenamic acid derivatives, biphenylcarboxylic acid derivatives, and oxicams. All of these NSAIDS are described in detail in Sunshine et al., US Pat. No. 4,985,459, issued Jan. 15, 1991, one of the references of this specification. Most preferred are aspirin, acetaminophen, ibuprofen, naproxen, benoxaprofen, flurbiprofen, fenoprofen, fenbufen, ketoprofen, indoprofen, pirprofen, carprofen, oxaprozin, pranoprofen, miloprofen, thioxa Propionic acid-based NSAIDS including, but not limited to, profen, suprofen, aluminoprofen, thiaprofenic acid, fluprofen, and bucloxic acid. Steroidal anti-inflammatory agents including hydrocortisone and the like are also useful.

Pharmaceutically active substances useful in the compositions of the present invention also include itching. Suitable itching agents for use herein include the pharmaceutically acceptable salts of metzolidine and trimeprazine.

[0038] Pharmaceutically active substances useful in the compositions of the present invention also include anesthetics. Anesthetics suitable for use herein include lidocaine, bupivacaine, chlorprocaine, dibucaine, etidocaine, mepivacaine, tetracaine, dyclonine,
There are pharmaceutically acceptable salts of hexylcaine, procaine, cocaine, ketamine, pramoxine and phenol.

Pharmaceutically active substances useful in the compositions of the present invention include antibacterial agents (antibacterial, antifungal, antiprotozoal and antiviral agents). Antimicrobial agents suitable for use herein include b-lactam drugs, quinolone drugs, ciprofloxacin, norfloxacin, tetracycline, erythromycin, amikacin, triclosan, doxycycline, capreomycin, chlorhexidine, chlortetracycline,
Pharmaceutically acceptable salts of oxytetracycline, clindamycin, ethambutol, metronidazole, pentamidine, gentamicin, kanamycin, lineeomycin, metacycline, methenamine, minocycline, neomycin, netilmycin, paromomycin, streptomycin, tobramycin, miconazole and amanfazine . Suitable antimicrobial agents for use herein include tetracycline hydrochloride, erythromycin-estriate, erythromycin-stearate (salt), amikacin-sulfate, doxycycline hydrochloride, capreomycin-sulfate, chlorhexidine-gluconate, Chlorhexidine hydrochloride, chlortetracycline hydrochloride, oxytetracycline hydrochloride, clindamycin hydrochloride, ethambutol hydrochloride, metronidazole hydrochloride, pentamidine hydrochloride, gentamicin-sulfate, kanamycin-sulfate, linenecomycin hydrochloride, metacycline hydrochloride, methenamine -Hiprate, methenamine-mandelate, minocycline hydrochloride, neomycin-sulfate, netilmycin-sulfate, paromomycin-sulfate DOO, streptomycin - sulfate, tobramycin - sulfate, miconazole hydrochloride, amanfadine hydrochloride, amanfadine - sulfate, triclosan, Ok Topirokkusu, para chloro - xylenol, nystatin, there is tolnaftate Contact and clotrimazole.

[0040] Sunscreens are also useful herein. A wide variety of sunscreens, 2 1992
U.S. Pat.No. 5,087,445 issued to Haffey et al. On May 11, Turner et al. U.S. Pat.No. 5,073,372 issued Dec. 17, 1991, and U.S. Pat. No. 5,073,371. In addition, Cosmetics Science and T echnology, in Chapter 8, 189 et seq., There is also a description by Segarin et al. These patents and articles are part of the references of this specification. Preferred among the sunscreens useful in the compositions of the present invention are 2-ethylhexyl p-methoxycinnamate, 2-
Ethylhexyl N, N-dimethyl-p-aminobenzoate, p-aminobenzoic acid,
2-phenylbenzimidazole-5-sulfonic acid, octocrylene, oxybenzone, homomenthyl-salicylate, octyl-salicylate, 4,4'-methoxy-
from the group consisting of t-butyldibenzoylmethane, 4-isopropyl-dibenzoylmethane, 3-benzylidene-camphor, 3- (4-methylbenzylidene) camphor, titanium dioxide, zinc oxide, silica, iron oxide, and mixtures thereof It is the one you have chosen.

Useful sunscreens include, among others, US Pat. No. 4,937,370 to Sabatelli et al., Issued June 26, 1990, and US Pat. No. 4,937,370 issued to Mar. 12, 1991. It is also described in 4,999,186. These two patents are part of the references of this specification. The sunscreens disclosed in these patents have, within one molecule, two chromophore moieties that exhibit different ultraviolet absorption spectra. One of the chromophore moieties absorbs primarily in the UVB region and the other absorbs strongly in the UVA region. These sunscreens are more efficient because they have a wider range of UV absorption, less penetration into the skin, and a longer persistence than ordinary sunscreens. Particularly preferred among these sunscreens are 4-N, N- (2-ethylhexyl) methylaminobenzoic acid ester of 2,4-dihydroxybenzophenone and 4-N, N- (4-hydroxydibenzoylmethane). 2-Ethylhexyl) methylaminobenzoic acid ester, 4-N, N- (2-ethylhexyl) methylaminobenzoic acid ester of 2-hydroxy-4- (2-hydroxyethoxy) benzophenone, 4- (2-hydroxyethoxy) 4-N, N- (2-ethylhexyl) methylaminobenzoic acid ester of dibenzoylmethane, and mixtures thereof.

In general, these compositions may contain from about 0.5 to about 20% of the sunscreens useful herein. The exact amount depends on the sunscreen chosen and the desired sun protection factor
(SPF). SPF is often used as a measure of the photoprotective effect of sunscreen on erythema. One of the references of this specification, dated August 25, 1978 Federal Gazette Vol. 43, No. 166, pp. 38206-38269.

[0043] Artificial sunscreens without sunlight, including dihydroxyacetone, glyceraldehyde, indoles, derivatives thereof, and the like, are also useful in the compositions of the present invention. These sunless artificial sunscreens can also be used in combination with sunscreens.

Other useful actives include, but are not limited to, skin bleaching agents (lightening agents) including hydroquinone, ascorbic acid, cordiic acid and sodium metasulfite.

Wetting Agents and Moisturizers The compositions of the present invention may include one or more moisturizing and moisturizing substances in addition to those already described herein. Various substances can be used,
Each may be present at a concentration of about 0.1 to about 20%, more preferably about 1 to about 10%, and most preferably about 2 to about 5% by weight of the composition. These materials include guanidine, glycolic acid and glycolate salts (eg, ammonium and quaternary alkyl ammonium salts); lactic acid and lactates (eg, ammonium and quaternary alkyl ammonium salts); various forms of aloe vera (eg, Sorbitol, glycerol, hexanetriol, polyhydroxy-alcohols such as propylene-glycol, butylene-glycol, hexylene-glycol; sugars and starches; sugar derivatives and starch derivatives (eg, alkoxylated glucose). Hyaluronic acid; lactamide-monoethanolamine; acetamide-monoethanolamine, and mixtures thereof.

Emulsifiers The compositions herein can include various emulsifiers. These emulsifiers are
Useful for emulsifying the various carrier components of the compositions herein. Suitable emulsifiers include a wide variety of nonionic, cationic, anionic, and zwitterionic emulsifiers disclosed in prior patents and other literature. Allured Publishing
McCutcheon's Detergents and Emulsifier , published by Corp., North American version (1
986), Clotti et al., US Pat. No. 5,011,681, issued Apr. 30, 1991, 1983
See Dixon et al., U.S. Patent No. 4,421,769, issued December 20, and Dickert et al., U.S. Patent No. 3,755,560, issued August 28, 1973. These documents are all part of the references in this specification.

[0047] Suitable types of emulsifiers include esters of glycerin, esters of propylene-glycol, fatty acid esters of polyethylene-glycol, polypropylene-
Glycol fatty acid esters, sorbitol esters, sorbitan anhydride esters, carboxylic acid copolymers, glucose esters and ethers, ethoxylated ethers, ethoxylated alcohols, alkyl phosphates, polyoxyethylene aliphatic There are ether phosphates, fatty amides, acyl lactylates, soaps and mixtures thereof.

Suitable emulsifiers include polyethylene-glycol 20 sorbitan-monolaurate (polysorbate 20), polyethylene-glycol 5 soybean oil-sterol, steareth-
20, ceteareth-20, PPG-2 methyl glucose ether-distearate, ceteth-1
0, polysorbate 80, cetyl phosphate, cetyl phosphate-potassium, diethanolamine-cetyl phosphate, polysorbate 60, glyceryl-stearate, PEG-100 stearate, and mixtures thereof, but are not limited thereto.

The emulsifier can be used alone or as a mixture of two or more, and can be used in an amount of about 0.1 to about 10%, more preferably about 1 to about 7%, and most preferably about 1 to about 10% by weight of the composition. It can be added at a concentration of 5%.

Carboxylic Acid Copolymer Thickener Another component useful in the compositions herein is a carboxylic acid copolymer thickener. These crosslinked polymers include acrylic acid, substituted acrylic acid, salts and esters of these acrylic acids and substituted acrylic acids. In this case, the crosslinker has two or more carbon-carbon double bonds and is derived from a polyhydric alcohol. There are generally two types of polymers suitable for use in this specification. The first type of polymer consists of acrylic acid monomers or derivatives thereof (eg, acrylic acid on its second and third carbons, respectively, C1-C4 alkyl, -CN, -COOH, and mixtures thereof). (There is a substituent selected from the group). The second type of polymer is an acrylic acid monomer or derivative thereof (as described in the sentence immediately above), a short chain alcohol (ie, C1-4) acrylate ester monomer or derivative thereof (eg, the acrylic acid portion of the ester is The second and third carbons each have a substituent selected from the group consisting of C1-C4 alkyl, -CN, -COOH, and mixtures thereof), and a second group selected from the group consisting of mixtures thereof. And a long-chain alcohol (ie, C8-40) acrylate ester monomer or derivative thereof (eg, the acrylic acid portion of the ester has, on its second and third carbons, C1-C4 alkyl, -CN, -C
OOH, and mixtures thereof) with a second monomer having a substituent selected from the group consisting of: OOH, and mixtures thereof. Blends of these two polymers are also useful herein.

For the first type of crosslinked homopolymer, the monomer is preferably selected from the group consisting of acrylic acid, methacrylic acid, ethacrylic acid, and mixtures thereof, with acrylic acid being most preferred. In a second type of crosslinked copolymer, the acrylic acid monomer or derivative thereof is preferably acrylic acid, methacrylic acid, ethacrylic acid,
And mixtures thereof, acrylic acid, methacrylic acid and mixtures thereof are most preferred. The short-chain alcohol-acrylate ester monomer or derivative thereof is preferably a C1-4 alcohol-acrylate ester, a C1-4 alcohol-methacrylate ester, a C1-4 alcohol-ethacrylate ester, and a mixture thereof. Selected from the group consisting of C1-4 alcohol-
Acrylate esters, C1-4 alcohol-methacrylate esters, and mixtures thereof are most preferred. The long-chain alcohol-acrylate ester monomer is selected from C8-40 alkyl-acrylate esters, and C10-30 alkyl
-Acrylate esters are preferred.

The crosslinking agent in these two types of polymers is a polyhydric alcohol polyalkenyl
-A polyether containing one or more alkenyl ether groups per molecule and the parent polyhydric alcohol having three or more carbon atoms and three or more hydroxyl groups. Suitable crosslinking agents are selected from the group consisting of allyl ethers of sucrose, allyl ethers of pentaerythritol and mixtures thereof. These polymers useful in the present invention are described in U.S. Pat. No. 5,087,445 to Haffey et al., Issued Feb. 11, 1992, and U.S. Pat.
No. 949, and Brown, US Pat. No. 2,798,053, issued Jul. 2, 1957. These patents are part of the references of this specification. See also one of the references in this specification, CTFA International Cosmetic Ingredient Dictionary , 4th edition, pp. 12 and 80.

Examples of the first class of commercially available homopolymers useful herein are:
There is a carbomer that is a homopolymer of acrylic acid cross-linked with an allyl ether of sucrose or pentaerythritol. Carbomer, BF G
It is sold by oodrich as the Carbopol ^R 900 series. Examples of the second class of commercially available copolymers useful herein include one or more acrylic acids,
Methacrylic acid or their short-chain (i.e., C _{1 to 4} alcohols) may copolymer of one and C10-30 alkyl acrylates esters, wherein the crosslinking agent of sucrose or pentaerythritol allyl (allyl) ether, It is. These copolymers are known as copolymers chromatography acrylates and C10-30 alkyl acrylates, sold by ^{BF Goodrich Carbopol R 1342, Pemulen TR} -1, and as Pemulen TR-2. In other words, examples of carboxylic acid polymer thickeners useful herein are carbomer, acrylate / C10-30 alkyl acrylate crosslinked polymers, and mixtures thereof.

The compositions of the present invention may comprise from about 0.025 to about 1% by weight, more preferably from about 0.05 to about 5%.
About 0.75%, and most preferably about 0.10 to about 0.50%, of a carboxylic acid polymer thickener can be included.

Other Additional Ingredients The compositions of the present invention can include a wide range of other additional ingredients. One of the references of this specification, CTFA Cosmetic Ingredient Handbook , 2nd edition, 199
Two years describe a wide variety of cosmetic and pharmaceutical ingredients commonly used in the hair and skin care industry that are suitable for use in the compositions of the present invention. On page 537 of this document, many examples of functional components are described. Examples of these functional ingredients include absorbents, abrasives, anti-acne, anti-caking agents, anti-foaming agents, antibacterial agents, antioxidants, binders, biological additives, buffers, extenders, chelating agents. Agents, chemical additives, coloring agents, cosmetic astringents, cosmetic biocides, denaturants, medicinal astringents, film formers, fragrance ingredients, opacifiers, pH regulators, plasticizers, preservatives, There are propellants, reducing agents, additional skin conditioning agents, suspending agents (non-surfactants), UV absorbers, and thickeners (aqueous and non-aqueous). Other examples of functional ingredients useful herein that are well known to those skilled in the art include solubilizers, sequestrants, and the like.

These additional ingredients listed in the CTFA Cosmetic Ingredient Handbook , as well as substances useful herein, include, in addition to vitamins and their derivatives (eg, vitamin C, vitamin A (ie, retinoic acid), retinol) , Retinoids, etc.);
Antioxidants; polyethylene glycols; polymers that promote the formation and substance of the film of the composition (eg, copolymers of eicosene and vinylpyrrolidone, one example being Ga
f Sold as Ganex ^R V-220 by Chemical Corp.); preservatives that maintain the antimicrobial state of the composition; antioxidants; chelating and sequestering agents; crosslinked and non-crosslinked cationic polyacrylamides. For example, CTFA name Polyquaternium
Salcar SC92 (and) mineral oil with 32, Salcar with CTFA designation Polyquaternium 37
e Contains SC95 (and) mineral oil (and) PPG-1 trideceth-6｝, and cosmetic ingredients such as fragrances, pigments, colorants, essential oils, skin sinates, astringents, skin soothing agents, and skin treatment agents. Examples of these cosmetic ingredients include clove oil, menthol, camphor, eucalyptus oil, eugenol, menthyl lactate, witch hazel distillate, bisabolol, dipotassium glycyrrhizinate, and the like.

Method of Use The compositions of the present invention are commonly used to protect from sunlight, prevent acne, prevent wrinkles and prevent skin aging, artificial tanning, analgesic effects, skin conditioning effects, facial moisturization. Effects, lip protection, skin cleansing effect, hair styling aid, etc., which can provide cosmetic and pharmacological effects suitable for this product. Such uses will depend on the type of composition employed, but will generally be applied topically to the hair or skin in an effective amount. "Effective amount" means an amount sufficient to achieve the desired effect. Typical amounts of the compositions of the present invention applied to hair or skin will depend on the type of composition and the desired effect, but will generally be in the range of about 1 to about 25 grams, with typical The amount is about 2 grams.

[0058] The following examples Examples, will be described in more detail some embodiments within the scope of the present invention. Since many variations of the invention are possible without departing from the spirit and scope of the invention, the examples are for illustrative purposes only and should not be construed as limiting the invention. Components are identified by chemical name or CTFA name.

Example 1 A topical composition as a shower product is prepared by blending the following components using an ordinary mixing method. This composition uses non-storing liquid polyol fatty acid polyester (liquid sucrose-polyester) and liquid oil to give a greasy, sticky, greasy skin feel, softening and cosmetic effect. A product.

Component weight% C12-14 alkyl ether glycerol 12.00 sodium sulfonate laureth-3 ammonium sulfate 3.00 myristic acid 1.00 myristic alcohol 1.00 cocoamidopropyl betaine 3.00 liquid sucrose polyester ^{* 1} 15. 3 Sodium EDTA 0.13 Glycerin 6.24 Fragrance 0.80 Polyquat-10 (JR-30M) 0.30 Glydant 0.20 Maleated soybean oil 1.00 Water (100 in total)

1: Liquid sucrose polyester is a mixture of hexa-, hepta-, and octa-sucrose-esters, mainly octaester esterified with mixed soybean oil fatty acids.

In a suitable container, add Polyquat-10 to distilled water and mix until fully hydrated. The surfactant and the water-soluble components are added and the mixture is heated to 70-80 ° C with stirring. In a separate container, mix the liquid sucrose-polyester and liquid oil, heat while mixing until uniform, and then add to the above mixture heated to 70-80 ° C. The mixture is cooled to 25-35 ° C with continued stirring. The glidant and perfume ingredients are then added with stirring and the mixture is cooled to room temperature.

Example 2 A topical composition as a shower product is prepared by blending the following components using a conventional mixing method. This composition uses non-storing liquid polyol fatty acid polyester (liquid sucrose-polyester) and liquid oil to give a greasy, sticky, greasy skin feel, softening and cosmetic effect. A product.

[0064] Ingredient Weight% Ammonium lauryl sulfate 3.15 laureth-3 sulfate 9.45 sodium lauroamphoacetate 5.40 Polyquaternium-10 0.30 Liquid Sucrose Polyester ¹ 15.3 mineral oil 3.00 EDTA 4 Sodium 0.13 Glycerin 3. 00 Fragrance 0.80 Citric acid 0.76 Lauryl alcohol 2.00 Water (100 in total)

1: Liquid sucrose polyether is a mixture of hexa-, hepta-, and octa-sucrose-esters, mainly octaester esterified with mixed soybean oil fatty acids.

In a suitable container, add Polyquaternium-10 to distilled water and mix until fully hydrated. Add a surfactant and a water-soluble component, and stir the mixture at 70 to 80C
Heat to In a separate vessel, the liquid sucrose-polyester is mixed with the liquid oil and lauryl alcohol, heated with mixing until uniform, and then added to the above mixture heated to 70-80 ° C. The mixture is stirred for 25-3
Cool to 5 ° C. The glidant and perfume ingredients are then added with stirring and the mixture is cooled to room temperature.

Example 3 A topical composition as a moisturizer is prepared by blending the following components using a conventional mixing method. This composition uses non-storing liquid polyol fatty acid polyester (liquid sucrose-polyester) and liquid oil, and does not leave a sticky, sticky, greasy skin feeling, emollient and cosmetic effect Product.

Ingredient weight% Cetyl alcohol 1.80 Stearic acid 0.25 Stearyl alcohol 1.20 Peg 100 stearate 0.25 Mineral oil 2.00 Liquid sucrose polyester ^{* 1} 4.00 Dimethicone 350 ² 0.50 Propyl paraben 10 Arlatone (RTM) 2121 ³ 1.00 Glycerin 9.00 Urea 2.00 Octyl-methoxycinnamate 2.00 Phenoxyethanol 0.25 Carbomer 1382 ⁴ 0.05 Carbomer 954 ⁵ 0.35 EDTA 4 Sodium 0.10 Titanium dioxide 0.15 Methylparaben 0.20 NaOH 0.22 Dimethicone Q-21403 ⁶ 1.00 Water (100 in total)

1: Liquid sucrose polyester is a mixture of hexa-, hepta-, and octa-sucrose-esters, mainly octaester esterified with mixed soybean oil fatty acids. 2: Dow Corning Dow Corning ^R 200 fluid (350 centistokes) 3: Sorbitan-stearate 95% by weight and sucrose-cocoate 5% by weight 4: BF Goodrich Carbopol ^R 1382 5: BF Goodrich Carbopol ^R 954 6: Dow Corning of Dow Corning ^R Q-2 1403, which is a mixture of dimethicone 85% and Jimechikonaru 15 wt%.

[0070] The liquid sucrose-polyester, Arlatone 2121 and other water-soluble ingredients are mixed in water and heated to prepare a first premix. The oil phase components other than silicones are mixed and heated to prepare a second premix, heated and added to the aqueous premix. The mixture obtained is cooled. The silicones are added to the resulting water-in-oil emulsion, the mixture is then cooled, and a small amount of the components are added.

──────────────────────────────────────────────────続 き Continuation of front page (81) Designated country EP (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE ), OA (BF, BJ, CF, CG, CI, CM, GA, GN, GW, ML, MR, NE, SN, TD, TG), AP (GH, GM, KE, LS, MW, SD, SZ, UG, ZW), EA (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM), AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, CA, CH, CN, CU, CZ, DE, DK, EE, ES, FI, GB, GE, GH, GM, HR, HU, ID, IL, IS, JP, KE, KG, KP , KR, KZ, LC, LK, LR, LS, LT, LU, LV, MD, MG, MK, MN, MW, MX, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, UA, UG, UZ, VN, YU, ZW Listro, Joseph Anthony Ohio, USA, Loveland, Waterford, Place 9680, Number 103 F term (reference) 4C083 AA121 AA122 AA162 AB032 AB242 AC011 AC072 AC122 AC242 AC342 AC351 AC352 AC421 AC422 AC441 AC442 AC482 AC532 AC682 AC712 AC791 AC792 AD071 AD152 CC03 CC04 CC05 CC11 CC12 CC13 CC19 CC23 CC24 CC38 DD33 EE06 EE07 EE12 EE14

Claims (10)

[Claims] (A) a melting point of −30 ° C. to 30 ° C., one polyol portion and one or more fatty acid portions, and the polyol portion has four or more free hydroxyl groups; From 0.1 to 99.9% by weight of a liquid polyol fatty acid polyester, wherein at least 60% of the groups are esterified with one or more fatty acid moieties having from 8 to 22 carbon atoms; and (b) the melting point is- 30 ° C to less than 30 ° C and substantially contains liquid polyol fatty acid polyesters, isohexadecane, isopropyl-palmitate, a blend of C13-C14 isoparaffins, polyacrylamide, and laureth-7, or mixtures thereof. A composition comprising 0.1 to 99.9% by weight of a liquid oil. (A) having a melting point of −30 ° C. to 30 ° C., one polyol portion and one or more fatty acid portions, and the polyol portion having four or more free hydroxyl groups; From 0.1 to 99.9% by weight of a liquid polyol fatty acid polyester, wherein at least 60% of the groups are esterified with one or more fatty acid moieties having from 8 to 22 carbon atoms; 0 ° C to less than 30 ° C and are substantially free of liquid polyol fatty acid polyesters, isohexadecane, isopropyl-palmitate, blends of C13-C14 isoparaffins, polyacrylamide, and laureth-7, or mixtures thereof , 0.1 to 99.9% by weight of a liquid oil; and (c) 0.1 to 99.9% by weight of a topical carrier. 3. The composition according to claim 1, wherein the fatty acid moiety contains from 8 to 18 carbon atoms. 4. A composition according to claim 1, wherein said polyol moiety is selected from the group consisting of erythritol, xylitol, sorbitol, glucose, sucrose, and mixtures thereof. 5. The composition according to claim 1, wherein the polyol moiety is sucrose. 6. The liquid oil is a mineral oil, a hydrocarbon having 5 to 16 carbon atoms, an aliphatic alcohol ester having 3 to 22 carbon atoms, a fatty acid having 3 to 30 carbon atoms. The composition according to any one of the preceding claims, wherein the composition is selected from the group consisting of esters, vegetable oils, and mixtures thereof. 7. The composition according to claim 2, wherein the topical carrier is an oil-in-water emulsion. 8. The composition according to claim 2, wherein the topical carrier is an anhydrous liquid solvent. 9. The composition according to claim 1, wherein the composition is a hand lotion, a body lotion, a skin conditioning cream, a skin protectant, a sunscreen, a cold cream,
Anti-acne compositions, skin renewal products, non-foaming cleansing lotions, moisturizers, facial moisturizers, makeup, foundations, lipsticks, lip protectants, hand cleansers, facial cleansers, body cleansers, shower products, shampoos, and 9. The composition according to claim 2, which is in the form of a mixture thereof. 10. A method for treating human hair or skin comprising topically applying a safe and effective amount of a composition according to any one of the preceding claims to a person in need of treatment. .