[go: up one dir, main page]
More Web Proxy on the site http://driver.im/

IL113245A - 3-De((2,6-dideoxy-3-c-methyl-3-o-methyl-alpha l-ribhexopyranosyl) oxy)-11,12-dideoxy-11,12-(n-heteroarylalkylimi-nocarbonyloxy)-6-o-methyl-3 oxy erythromycin derivatives their preparation process and pharmaceutical compositions containing them - Google Patents

3-De((2,6-dideoxy-3-c-methyl-3-o-methyl-alpha l-ribhexopyranosyl) oxy)-11,12-dideoxy-11,12-(n-heteroarylalkylimi-nocarbonyloxy)-6-o-methyl-3 oxy erythromycin derivatives their preparation process and pharmaceutical compositions containing them

Info

Publication number
IL113245A
IL113245A IL11324595A IL11324595A IL113245A IL 113245 A IL113245 A IL 113245A IL 11324595 A IL11324595 A IL 11324595A IL 11324595 A IL11324595 A IL 11324595A IL 113245 A IL113245 A IL 113245A
Authority
IL
Israel
Prior art keywords
methyl
dideoxy
oxy
ribhexopyranosyl
heteroarylalkylimi
Prior art date
Application number
IL11324595A
Other languages
English (en)
Other versions
IL113245A0 (en
Original Assignee
Roussel Uclaf
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roussel Uclaf filed Critical Roussel Uclaf
Publication of IL113245A0 publication Critical patent/IL113245A0/xx
Publication of IL113245A publication Critical patent/IL113245A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/10—Anti-acne agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Virology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
  • Quinoline Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
IL11324595A 1994-05-03 1995-04-04 3-De((2,6-dideoxy-3-c-methyl-3-o-methyl-alpha l-ribhexopyranosyl) oxy)-11,12-dideoxy-11,12-(n-heteroarylalkylimi-nocarbonyloxy)-6-o-methyl-3 oxy erythromycin derivatives their preparation process and pharmaceutical compositions containing them IL113245A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9405368A FR2719587B1 (fr) 1994-05-03 1994-05-03 Nouveaux dérivés de l'érythromycine, leur procédé de préparation et leur application comme médicaments.

Publications (2)

Publication Number Publication Date
IL113245A0 IL113245A0 (en) 1995-07-31
IL113245A true IL113245A (en) 1999-11-30

Family

ID=9462785

Family Applications (1)

Application Number Title Priority Date Filing Date
IL11324595A IL113245A (en) 1994-05-03 1995-04-04 3-De((2,6-dideoxy-3-c-methyl-3-o-methyl-alpha l-ribhexopyranosyl) oxy)-11,12-dideoxy-11,12-(n-heteroarylalkylimi-nocarbonyloxy)-6-o-methyl-3 oxy erythromycin derivatives their preparation process and pharmaceutical compositions containing them

Country Status (42)

Country Link
US (2) US5635485A (pl)
EP (1) EP0680967B1 (pl)
JP (4) JP2992540B2 (pl)
KR (1) KR100312267B1 (pl)
CN (2) CN1052984C (pl)
AP (1) AP558A (pl)
AT (1) ATE172203T1 (pl)
AU (1) AU684027B2 (pl)
BG (1) BG63087B1 (pl)
BR (1) BR9507700A (pl)
CA (1) CA2189271C (pl)
CZ (1) CZ293455B6 (pl)
DE (2) DE10299001I1 (pl)
DK (1) DK0680967T3 (pl)
DZ (1) DZ1878A1 (pl)
EE (1) EE03263B1 (pl)
ES (1) ES2122472T3 (pl)
FI (1) FI111263B (pl)
FR (1) FR2719587B1 (pl)
GE (1) GEP19991538B (pl)
HU (2) HU219599B (pl)
IL (1) IL113245A (pl)
LU (1) LU90872I2 (pl)
LV (1) LV11739B (pl)
MA (1) MA23534A1 (pl)
MD (1) MD1233C2 (pl)
NL (1) NL300077I1 (pl)
NO (2) NO308853B1 (pl)
NZ (1) NZ285416A (pl)
OA (1) OA10319A (pl)
PL (1) PL182034B1 (pl)
RO (1) RO113350B1 (pl)
RU (1) RU2144036C1 (pl)
SI (1) SI0680967T1 (pl)
SK (1) SK281707B6 (pl)
TJ (1) TJ313B (pl)
TN (1) TNSN95049A1 (pl)
TW (1) TW341573B (pl)
UA (1) UA51618C2 (pl)
WO (1) WO1995029929A1 (pl)
YU (1) YU49235B (pl)
ZA (1) ZA953501B (pl)

Families Citing this family (86)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU6241796A (en) * 1995-06-27 1997-01-30 Takeda Chemical Industries Ltd. 4-acylamino(halogeno) alkyl-quinoline derivatives, their preparation and their use as melatonin agonists
FR2742757B1 (fr) * 1995-12-22 1998-01-30 Roussel Uclaf Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments
DK0929563T3 (da) * 1996-09-04 2005-10-03 Abbott Lab 6-O-substituerede ketolider med antibakteriel aktivitet
UA51730C2 (uk) * 1996-09-04 2002-12-16 Ебботт Лабораторіз 6-o-заміщені кетоліди з антибактеріальною активністю, спосіб їх одержання (варіанти), фармацевтична композиція та спосіб регулювання бактеріальної інфекції у ссавців
FR2757168B1 (fr) * 1996-12-12 1999-06-11 Hoechst Marion Roussel Inc Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments
FR2760017B1 (fr) * 1997-02-27 1999-04-30 Hoechst Marion Roussel Inc Nouveaux derives de l'erytromycine, leur procede de preparation et leur application comme medicaments
US5780605A (en) * 1997-09-08 1998-07-14 Abbott Laboratories 6,9-bridged erythromycin derivatives
FR2771008B1 (fr) * 1997-11-17 2000-04-28 Hoechst Marion Roussel Inc Utilisation des ketolides pour la preparation de compositions pharmaceutiques destinees a prevenir les complications thrombotiques arterielles liees a l'atherosclerose
JP4573925B2 (ja) * 1998-07-09 2010-11-04 アベンティス・ファーマ・ソシエテ・アノニム 新規のエリスロマイシン誘導体、その製造方法及びその薬剤としての使用
FR2781484B1 (fr) * 1998-07-21 2001-08-10 Hoechst Marion Roussel Inc Nouveaux derives de la 6-deoxy erythromycine, leur procede de preparation et leur application comme medicaments
EP1115732B1 (en) * 1998-09-22 2005-06-29 Pfizer Products Inc. Carbamate and carbazate ketolide antibiotics
FR2785612A1 (fr) * 1998-11-10 2000-05-12 Hoechst Marion Roussel Inc Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments
FR2786188B1 (fr) * 1998-11-24 2002-10-31 Hoechst Marion Roussel Inc Nouveaux derives de l'erythromycine, leur procede de preparation et leur applicaion comme medicaments
TW526202B (en) 1998-11-27 2003-04-01 Shionogi & Amp Co Broad spectrum cephem having benzo[4,5-b]pyridium methyl group of antibiotic activity
EP1137654A1 (en) 1998-12-10 2001-10-04 Pfizer Products Inc. Carbamate and carbazate ketolide antibiotics
IL144178A0 (en) * 1999-01-27 2002-05-23 Pfizer Prod Inc Ketolide antibiotics
FR2789392B1 (fr) * 1999-02-04 2001-10-05 Hoechst Marion Roussel Inc Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments
US6054435A (en) * 1999-03-19 2000-04-25 Abbott Laboratories 6-O-substituted macrolides having antibacterial activity
US6590083B1 (en) 1999-04-16 2003-07-08 Ortho-Mcneil Pharmaceutical, Inc. Ketolide antibacterials
US6514944B2 (en) 1999-04-16 2003-02-04 Kosan Biosciences, Inc. Macrolide antiinfective agents
CN1373767A (zh) 1999-04-16 2002-10-09 奥索-麦克尼尔药品公司 酮式大环内酯抗菌剂
BR0010680A (pt) 1999-04-16 2002-02-19 Kosan Biosciences Inc Agentes antiinfecciosos de macrolìdeo
US6451768B1 (en) 1999-04-16 2002-09-17 Kosan Biosciences, Inc. Macrolide antiinfective agents
US6939861B2 (en) * 1999-04-16 2005-09-06 Kosan Biosciences, Inc. Amido macrolides
CZ20013733A3 (cs) * 1999-05-24 2002-11-13 Pfizer Products Inc. Deriváty 13-methylerythromycinu
FR2797875B1 (fr) * 1999-08-26 2001-10-19 Hoechst Marion Roussel Inc Agglomerats spheriques de telithromycine, leur procede de preparation et leur application dans la preparation de formes pharmaceutiques
US6946446B2 (en) 2000-02-24 2005-09-20 Abbott Laboratories Anti-infective agents useful against multidrug-resistant strains of bacteria
KR100502031B1 (ko) * 2000-08-22 2005-07-25 바실리어 파마슈티카 아게 항균 활성을 갖는 신규한 매크롤라이드
FR2821747B1 (fr) * 2001-03-09 2004-07-02 Ethypharm Lab Prod Ethiques Suspension de telithromycine a gout masque
WO2003004509A2 (en) * 2001-07-03 2003-01-16 Chiron Corporation C12 modified erythromycin macrolides and ketolides having antibacterial activity
US8063021B2 (en) * 2002-01-17 2011-11-22 Kosan Biosciences Incorporated Ketolide anti-infective compounds
US6995143B2 (en) 2002-02-28 2006-02-07 Basilea Pharmaceutica Ag Macrolides with antibacterial activity
JP4790263B2 (ja) 2002-07-08 2011-10-12 グラクソ グループ リミテッド 炎症性の疾患および病態を治療する新規な化合物、組成物および方法
US7157433B2 (en) 2002-07-08 2007-01-02 Glaxosmithkline Istrazivacki Centar Zagreb Compounds, compositions as carriers for steroid/nonsteroid anti-inflammatory; antienoplastic and antiviral active molecules
WO2004009059A1 (en) * 2002-07-19 2004-01-29 Aventis Pharma S.A. Taste masked oral composition of telithromycin
US20040013737A1 (en) * 2002-07-19 2004-01-22 Philippe Becourt Taste masked oral composition of telithromycin
AR043050A1 (es) 2002-09-26 2005-07-13 Rib X Pharmaceuticals Inc Compuestos heterociclicos bifuncionales y metodos para preparar y usar los mismos
DE10305391A1 (de) * 2003-02-11 2004-08-19 Aventis Pharma Deutschland Gmbh Verfahren zur Herstellung von Pyridin-substituierten Aminoketal-Derivaten
US6916934B2 (en) * 2003-02-11 2005-07-12 Aventis Pharma Deutschland Gmbh Process for preparing pyridine-substituted amino ketal derivatives
EP3738591A3 (en) 2003-03-10 2021-03-24 Merck Sharp & Dohme Corp. Novel antibacterial agents
CA2523541A1 (en) * 2003-04-25 2004-11-11 Chiron Corporation Novel ketolide derivatives
US20050101548A1 (en) * 2003-09-12 2005-05-12 Xiaodong Lin Antimicrobial derivatives
GB0402578D0 (en) * 2004-02-05 2004-03-10 Cambridge Theranostics Ltd Methods of treatment of atherosclerosis
US8202843B2 (en) 2004-02-27 2012-06-19 Rib-X Pharmaceuticals, Inc. Macrocyclic compounds and methods of making and using the same
AU2005238313A1 (en) * 2004-04-28 2005-11-10 Alembic Limited Process for the preparation of telithromycin
BRPI0513903A (pt) * 2004-07-28 2008-05-20 Ranbaxy Lab Ltd derivados de cetolìdeos úteis como agentes antimicrobianos, seus processos de preparação e composições farmacêuticas compreendendo os mesmos
EP1807439A2 (en) * 2004-10-25 2007-07-18 Ranbaxy Laboratories Limited Ketolide derivatives as antibacterial agents
PT1836211E (pt) 2004-12-21 2010-04-08 Pfizer Prod Inc Macrólidos
CN102290175B (zh) * 2005-02-08 2014-06-11 株式会社村田制作所 表面安装型负特性热敏电阻
FR2882522B1 (fr) 2005-02-25 2007-04-13 Aventis Pharma Sa Composition pharmaceutique solide comprenant de la telithromycine
WO2006129257A2 (en) * 2005-05-30 2006-12-07 Ranbaxy Laboratories Limited Ketolide derivatives as antibacterial agents
WO2007039914A2 (en) * 2005-10-06 2007-04-12 Alembic Limited Novel polymorphs of telithromycin
WO2007049296A2 (en) * 2005-10-28 2007-05-03 Alembic Limited Amorphous form of telithromycin
US20070167382A1 (en) * 2005-11-15 2007-07-19 Nina Finkelstein Crystalline and amorphous forms of telithromycin
WO2007060627A2 (en) * 2005-11-23 2007-05-31 Ranbaxy Laboratories Limited Use of macrolide derivatives for treating acne
US20090005325A1 (en) * 2005-11-23 2009-01-01 Biswajit Bas Ketolide Derivatives as Antibacterial Agents
EP1960413A2 (en) * 2005-11-23 2008-08-27 Ranbaxy Laboratories Limited Macrolides derivatives as antibacterial agents
US7595300B2 (en) 2005-12-13 2009-09-29 Kosan Biosciences Incorporated 7-quinolyl ketolide antibacterial agents
GB0600238D0 (en) * 2006-01-06 2006-02-15 Sandoz Ag Organic compounds
US8097708B2 (en) * 2006-02-07 2012-01-17 Taisho Pharmaceutical Co., Ltd. 10a-Azalide compound
EP2056844A4 (en) 2006-08-24 2010-11-24 Wockhardt Research Center NEW MACROLIDS AND KETOLIDS WITH ANTIMICROBIAL EFFECT
WO2008023383A1 (en) * 2006-08-25 2008-02-28 Alembic Limited Novel process for the preparation of telithromycin
ES2306590B1 (es) * 2006-12-15 2009-08-07 Ercros Industrial,S .A. Formas cristalinas i y ii de telitromicina.
US8293715B2 (en) * 2007-08-06 2012-10-23 Taisho Pharmaceutical Co., Ltd. 10a-Azalide compound crosslinked at 10a- and 12-positions
US20090075917A1 (en) * 2007-09-19 2009-03-19 Protia, Llc Deuterium-enriched telithromycin
US7926879B2 (en) 2007-09-20 2011-04-19 Herman Miller, Inc. Load support structure
CN105732745A (zh) 2007-10-25 2016-07-06 森普拉制药公司 大环内酯类抗菌剂的制备方法
WO2009053259A1 (en) * 2007-10-25 2009-04-30 Sandoz Ag Process for the production of telithromycin
US8299035B2 (en) * 2008-05-15 2012-10-30 Taisho Pharmaceutucal Co., Ltd. 10a-azalide compound having 4-membered ring structure
EP3031460A1 (en) * 2008-10-24 2016-06-15 Cempra Pharmaceuticals Inc. Biodefenses using triazole-containing macrolides
MX2011012614A (es) 2009-05-27 2012-02-22 Wockhardt Ltd Compuestos de quetolida que tienen actividad antimicrobiana.
US9937194B1 (en) 2009-06-12 2018-04-10 Cempra Pharmaceuticals, Inc. Compounds and methods for treating inflammatory diseases
US9480679B2 (en) 2009-09-10 2016-11-01 Cempra Pharmaceuticals, Inc. Methods for treating malaria, tuberculosis and MAC diseases
DK2550286T3 (en) 2010-03-22 2016-02-29 Cempra Pharmaceuticals Inc CRYSTALLINE FORMS OF A MACROLID AND APPLICATIONS THEREOF
JP6184319B2 (ja) 2010-05-20 2017-08-23 センプラ ファーマシューティカルズ，インコーポレイテッド マクロライド類およびケトライド類ならびにその中間体を調製するための工程
EP2613630A4 (en) * 2010-09-10 2014-01-15 Cempra Pharmaceuticals Inc FLUOROCETOLIDES FORMING HYDROGEN LINKS TO TREAT DISEASES
CN103384676B (zh) 2010-12-09 2016-02-03 沃克哈特有限公司 酮内酯化合物
AR085286A1 (es) 2011-02-21 2013-09-18 Taisho Pharmaceutical Co Ltd Derivado de macrolido sustituido en la posicion c-4
EP2681222B1 (en) 2011-03-01 2018-02-28 Wockhardt Limited Process for preparation of ketolide intermediates
US8993739B2 (en) 2011-03-22 2015-03-31 Wockhardt Ltd. Process for preparation of ketolide compounds
HK1205939A1 (en) 2012-03-27 2015-12-31 Cempra Pharmaceuticals, Inc. Parenteral formulations for administering macrolide antibiotics
CN105163785A (zh) 2013-03-14 2015-12-16 森普拉制药公司 用于治疗呼吸道疾病的方法及其制剂
AU2014233240B2 (en) 2013-03-15 2018-08-09 Cempra Pharmaceuticals, Inc. Convergent processes for preparing macrolide antibacterial agents
CN105524132B (zh) * 2014-09-30 2019-07-02 中国医学科学院药物研究所 含有喹啉取代基的红霉素a酮内酯类抗生素衍生物、其制备方法及应用
DE102015201783A1 (de) 2015-02-02 2016-08-04 Friedrich Baur Verfahren zur Herstellung eines Füllstoffs aus Textilfasern sowie Textil mit einem solchen Füllstoff
CN107129514B (zh) * 2016-03-02 2019-12-13 中国医学科学院药物研究所 红霉素a酮内酯类抗生素衍生物、其制备方法及应用

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT342770B (de) * 1975-04-07 1978-04-25 Thomae Gmbh Dr K Verfahren zur herstellung neuer erythromycinderivate
DE2833140A1 (de) * 1978-07-28 1980-02-07 Boehringer Sohn Ingelheim Neue n-substituierte heterocyclen
US4434174A (en) * 1980-02-11 1984-02-28 Berlex Laboratories, Inc. Treating cardiovascular diseases with N-(3-phenoxy-2-hydroxypropyl)benzimidazole-1-alkanamines
IE810250L (en) * 1980-02-11 1981-08-11 Berlex Lab N-(3-phenoxy-2-hydroxypropyl) benzimidazole -1-¹alkanamines.
US4568687A (en) * 1983-02-28 1986-02-04 American Cyanamid Company N-[2-4-(1H-Imidazol-1-yl)alkyl]-arylamides and pharmaceutical compositions
US4489089A (en) * 1983-04-06 1984-12-18 American Cyanamid Company Substituted N-[ω-(1H-imidazol-1-yl)alkyl]-amides
ZA84949B (en) * 1983-04-06 1984-09-26 American Cyanamid Co Substituted-n-(2-4-(1h-imidazol-1-yl)alkyl)substituted amides
AU573828B2 (en) * 1984-05-17 1988-06-23 E.R. Squibb & Sons, Inc. Tetrahydronaphthalenols
GB8425104D0 (en) * 1984-10-04 1984-11-07 Ici America Inc Amide derivatives
DE3540376A1 (de) * 1985-11-14 1987-05-21 Bayer Ag Verfahren zur inhibierung der wasserstoffinduzierten korrosion von metallischen werkstoffen
ATE106884T1 (de) * 1986-10-29 1994-06-15 Pfizer Verfahren zur herstellung von 2-(1-pentyl-3- guanidino)-4-(2-methyl-4-imidazolyl)thiazol und dessen kristallinisches dihydrochlorid-trihydrat.
DE3930669A1 (de) * 1989-09-14 1991-03-28 Basf Ag Verfahren zur herstellung von uretdiongruppen aufweisenden polyisocyanaten
JP2899028B2 (ja) * 1989-12-01 1999-06-02 協和醗酵工業株式会社 ジベンゾオキセピン誘導体
IL99995A (en) * 1990-11-21 1997-11-20 Roussel Uclaf Erythromycin derivatives, their preparation and pharmaceutical compositions containing them
ATE157368T1 (de) * 1990-11-28 1997-09-15 Taisho Pharmaceutical Co Ltd 6-0-methylerythromycin a-derivat
FR2692579B1 (fr) * 1992-06-19 1995-06-02 Roussel Uclaf Nouveaux dérivés de la picromycine, leur procédé de préparation et leur application comme médicaments.
US5527780A (en) * 1992-11-05 1996-06-18 Roussel Uclaf Erythromycin derivatives
FR2697524B1 (fr) * 1992-11-05 1994-12-23 Roussel Uclaf Nouveaux dérivés de l'érythromycine, leur procédé de préparation et leur application comme médicaments.
TW370529B (en) * 1992-12-17 1999-09-21 Pfizer Pyrazolopyrimidines
HRP930014A2 (en) * 1993-01-08 1994-08-31 Pliva Pharm & Chem Works 9-deoxo-9a-aza-11-deoxy-9a-homoeritromycin a 9a, 11-cyclic carbamates

Also Published As

Publication number Publication date
CA2189271C (fr) 2005-12-27
NZ285416A (en) 1997-07-27
BR9507700A (pt) 1997-08-19
NO964654D0 (no) 1996-11-04
NO308853B1 (no) 2000-11-06
SK140296A3 (en) 1998-04-08
EP0680967B1 (fr) 1998-10-14
CA2189271A1 (fr) 1995-11-09
WO1995029929A1 (fr) 1995-11-09
BG100951A (en) 1997-08-29
LV11739A (lv) 1997-04-20
DE69505296D1 (de) 1998-11-19
TJ313B (en) 2001-08-06
ZA953501B (en) 1996-05-02
NO2001027I1 (no) 2002-01-28
MA23534A1 (fr) 1995-12-31
HU219599B (hu) 2001-05-28
FI964395A0 (fi) 1996-10-31
PL182034B1 (pl) 2001-10-31
EE03263B1 (et) 2000-04-17
AP9500744A0 (en) 1995-07-31
NL300077I1 (nl) 2002-03-01
CZ293455B6 (cs) 2004-05-12
AP558A (en) 1996-11-07
AU684027B2 (en) 1997-11-27
CN1229082A (zh) 1999-09-22
FR2719587B1 (fr) 1996-07-12
FI111263B (fi) 2003-06-30
SI0680967T1 (en) 1999-02-28
HUT75698A (en) 1997-05-28
CN1052984C (zh) 2000-05-31
JP4658902B2 (ja) 2011-03-23
MX9605208A (es) 1997-09-30
KR100312267B1 (ko) 2002-06-22
BG63087B1 (bg) 2001-03-30
SK281707B6 (sk) 2001-07-10
YU49235B (sh) 2004-12-31
JPH0853489A (ja) 1996-02-27
CN1088709C (zh) 2002-08-07
RU2144036C1 (ru) 2000-01-10
DZ1878A1 (fr) 2002-02-17
NO964654L (no) 1996-11-04
EP0680967A1 (fr) 1995-11-08
HU227493B1 (en) 2011-07-28
HU9603038D0 (en) 1997-01-28
TW341573B (en) 1998-10-01
CZ321496A3 (en) 1997-08-13
YU27095A (sh) 1998-05-15
OA10319A (fr) 1997-10-07
DE10299001I2 (de) 2012-07-05
CN1151746A (zh) 1997-06-11
ES2122472T3 (es) 1998-12-16
UA51618C2 (uk) 2002-12-16
FI964395L (fi) 1996-10-31
DK0680967T3 (da) 1999-06-23
GEP19991538B (en) 1999-03-05
HK1010732A1 (en) 1999-06-25
DE69505296T2 (de) 1999-04-22
LV11739B (en) 1997-08-20
ATE172203T1 (de) 1998-10-15
DE10299001I1 (de) 2012-07-05
JP2007045847A (ja) 2007-02-22
JPH11152296A (ja) 1999-06-08
RO113350B1 (ro) 1998-06-30
TNSN95049A1 (fr) 1996-02-06
US5635485A (en) 1997-06-03
MD1233C2 (ro) 2000-10-31
JP4750755B2 (ja) 2011-08-17
JP2007269810A (ja) 2007-10-18
JP2992540B2 (ja) 1999-12-20
HU9904687D0 (en) 2000-03-28
US6100404A (en) 2000-08-08
IL113245A0 (en) 1995-07-31
AU2449995A (en) 1995-11-29
PL317071A1 (en) 1997-03-03
JP3998828B2 (ja) 2007-10-31
MD1233B1 (en) 1999-05-31
LU90872I2 (fr) 2002-03-12
FR2719587A1 (fr) 1995-11-10

Similar Documents

Publication Publication Date Title
IL113245A (en) 3-De((2,6-dideoxy-3-c-methyl-3-o-methyl-alpha l-ribhexopyranosyl) oxy)-11,12-dideoxy-11,12-(n-heteroarylalkylimi-nocarbonyloxy)-6-o-methyl-3 oxy erythromycin derivatives their preparation process and pharmaceutical compositions containing them
IL112954A (en) 11,12-dideoxy-3-de(2,6-dideoxy-3-C-methyl-3-O-methylalpha-L-ribohexapyranosyl)oxy)-6-O-methyl-3-oxo-12,11-(oxycarbonyl hydrazono)-erythromycin derivatives their preparation process and their use as medicaments
IL87290A0 (en) Epipodophyllotoxin glucoside 4'-phosphate derivatives,their preparation and pharmaceutical compositions containing them
HUP0002252A3 (en) 9-oxime erythromycin derivatives, process for preparing them and pharmaceutical compositions containing them
HUP9602635A2 (en) 4-aciloxy-benzenesulfonamide derivatives, process for their preparation and pharmaceutical compositions containing them
IL98864A0 (en) Oxazolyl derivatives,process for their preparation and pharmaceutical compositions containing them
IL114059A0 (en) Phenethanolamine derivatives pharmaceutical compositions containing them process for their preparation and their use
IL141956A0 (en) Benzothiazolone derivatives, process for their preparation and pharmaceutical compositions containing them
GR3034582T3 (en) Substituted 4-phenyl thiazole derivatives, process for their preparation and pharmaceutical compositions containing them
HUP0003174A3 (en) 20(s) camptothecin glycoconjugates, process for their preparation and pharmaceutical compositions containing them
IL105215A0 (en) 9-fluoro-7-oxo-7h-pyrido(1,2,3-de)(1,4)benzoxazine-6-carboxylic acids and their esters,their preparation and pharmaceutical compositions containing them
HUP9601062A2 (en) Chromone derivatives, pharmaceutical compositions containing them and process for their preparation
IL82820A0 (en) Anthracycline glycosides,their preparation and pharmaceutical compositions containing them
IL105214A0 (en) 7-oxo-7h-pyrido(1,2,3-de)(1,4)benzoxazine-6-carboxylic acids and their esters,their preparation and pharmaceutical compositions containing them
HUP9801068A3 (en) 1,2,3,4-tetrahydro-2-naphtaleneamine derivatives, process for their preparation, their use, and pharmaceutical compositions containing them
IL84146A0 (en) Anthracycline glycosides,their preparation and pharmaceutical compositions containing them
IL86888A0 (en) 3',4'-dinitrogen substituted epipodophyllotoxin glucoside derivatives and pharmaceutical compositions containing them
EP0418020A3 (en) Cephalosporinderivatives, process for their preparation and pharmaceutical compositions
HUP9900079A3 (en) 12h-dibenzo[d,g][1,3]dioxocine derivatives, process for their preparation, their use and pharmaceutical compositions containing the same
IL93676A0 (en) Anthracycline derivatives,their preparation and pharmaceutical compositions containing them
HUP9600061A3 (en) 3-alkoxycarbonyl-1,3,4-thiadiazin-2-on derivatives, process for their preparation and pharmaceutical compositions containing the same
ZA898179B (en) Tylosin derivatives,process for the preparation thereof and pharmaceutical compositions containing them
IL111797A0 (en) Thionophosphate derivatives, process for their preparation and pharmaceutical compositions containing them
IL113649A0 (en) 8-amino-pyrido [1,2,3-d, e] [1,3,4] benzoxadiazine derivatives their preparation and pharmaceutical compositions containing them
SG33434A1 (en) Pharmaceutical preparation containing estra-1,3,5(10)-triene-derivatives

Legal Events

Date Code Title Description
FF Patent granted
HCE Change of name and address of proprietor(s)
KB Patent renewed
KB Patent renewed
HCA Change of name of proprietor(s) after amalgamation
EXTP Application for extension order is pending
KB Patent renewed
KB Patent renewed
KB Patent renewed
EXP Patent expired