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HUT45053A - Process for producing 7-(/meta-substituted/-phenyl-glycin-amido)-1-carba-1-detia-cefems - Google Patents

Process for producing 7-(/meta-substituted/-phenyl-glycin-amido)-1-carba-1-detia-cefems

Info

Publication number
HUT45053A
HUT45053A HU874452A HU445287A HUT45053A HU T45053 A HUT45053 A HU T45053A HU 874452 A HU874452 A HU 874452A HU 445287 A HU445287 A HU 445287A HU T45053 A HUT45053 A HU T45053A
Authority
HU
Hungary
Prior art keywords
cefems
detia
glycin
carba
amido
Prior art date
Application number
HU874452A
Other languages
English (en)
Other versions
HU200179B (en
Inventor
Robin D Cooper
John A Webber
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of HUT45053A publication Critical patent/HUT45053A/hu
Publication of HU200179B publication Critical patent/HU200179B/hu

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D463/00Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D463/10Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D463/14Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hetero atoms directly attached in position 7
    • C07D463/16Nitrogen atoms
    • C07D463/18Nitrogen atoms further acylated by radicals derived from carboxylic acids or by nitrogen or sulfur analogues thereof
    • C07D463/20Nitrogen atoms further acylated by radicals derived from carboxylic acids or by nitrogen or sulfur analogues thereof with the acylating radicals further substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D463/22Nitrogen atoms further acylated by radicals derived from carboxylic acids or by nitrogen or sulfur analogues thereof with the acylating radicals further substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen further substituted by nitrogen atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Cephalosporin Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
HU874452A 1986-10-03 1987-10-02 Process for producing 7-square brackets open/meta-substituted/-phenylglycine-amido square brackets closed-1-carba-1-dethiacefems HU200179B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US91517386A 1986-10-03 1986-10-03

Publications (2)

Publication Number Publication Date
HUT45053A true HUT45053A (en) 1988-05-30
HU200179B HU200179B (en) 1990-04-28

Family

ID=25435354

Family Applications (1)

Application Number Title Priority Date Filing Date
HU874452A HU200179B (en) 1986-10-03 1987-10-02 Process for producing 7-square brackets open/meta-substituted/-phenylglycine-amido square brackets closed-1-carba-1-dethiacefems

Country Status (17)

Country Link
EP (1) EP0266896B1 (hu)
JP (1) JPS6396186A (hu)
KR (1) KR880005125A (hu)
CN (1) CN87107149A (hu)
AT (2) ATE79119T1 (hu)
BG (1) BG47034A3 (hu)
DE (1) DE3780909T2 (hu)
DK (1) DK518487A (hu)
FI (1) FI874311A7 (hu)
GR (1) GR3005920T3 (hu)
HU (1) HU200179B (hu)
IE (1) IE872646L (hu)
IL (1) IL84051A0 (hu)
NZ (1) NZ222015A (hu)
PL (1) PL151703B1 (hu)
PT (1) PT85850B (hu)
ZA (1) ZA877398B (hu)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ227842A (en) * 1988-02-05 1990-12-21 Lilly Co Eli Crystalline 2.5-hydrate form of a beta-lactam
US6982251B2 (en) 2000-12-20 2006-01-03 Schering Corporation Substituted 2-azetidinones useful as hypocholesterolemic agents
KR100820983B1 (ko) 2001-01-26 2008-04-10 쉐링 코포레이션 치환된 아제티딘온 화합물을 포함하는 약제학적 조성물
BR0206654A (pt) 2001-01-26 2004-02-25 Schering Corp Combinações de ativador(es) de receptor ativado por proliferação de peroxisoma (ppar) e inibidor(es) de absorção de esterol e tratamentos para indicações vasculares
US7071181B2 (en) 2001-01-26 2006-07-04 Schering Corporation Methods and therapeutic combinations for the treatment of diabetes using sterol absorption inhibitors
MXPA03008803A (es) 2001-03-28 2004-02-18 Schering Corp Sintesis enantioselelctiva de compuestos intermedios de azetidinona.
US7053080B2 (en) 2001-09-21 2006-05-30 Schering Corporation Methods and therapeutic combinations for the treatment of obesity using sterol absorption inhibitors
MXPA04002573A (es) 2001-09-21 2004-06-18 Schering Corp Tratamiento de xantoma con derivados de azetidinona como inhibidores de la absorcion de esterol.
US7056906B2 (en) 2001-09-21 2006-06-06 Schering Corporation Combinations of hormone replacement therapy composition(s) and sterol absorption inhibitor(s) and treatments for vascular conditions in post-menopausal women
US20030236243A1 (en) * 2002-05-14 2003-12-25 Shoichet Brian K. Sterically-awkward beta-lactamase inhibitors
AU2003291719A1 (en) 2002-11-06 2004-06-03 Schering Corporation Cholesterol absorptions inhibitors for the treatment of autoimmune disorders
EP1601668B1 (en) 2003-03-07 2008-08-27 Schering Corporation Substituted azetidinone compounds, formulations and uses thereof for the treatment of hypercholesterolemia
US7459442B2 (en) 2003-03-07 2008-12-02 Schering Corporation Substituted azetidinone compounds, processes for preparing the same, formulations and uses thereof
US7208486B2 (en) 2003-03-07 2007-04-24 Schering Corporation Substituted azetidinone compounds, processes for preparing the same, formulations and uses thereof
JP2006519869A (ja) 2003-03-07 2006-08-31 シェーリング コーポレイション 置換アゼチジノン化合物、置換アゼチジノン化合物を調製するためのプロセス、それらの処方物および使用
CN102144992B (zh) * 2011-03-10 2013-04-10 浙江大学 苯基甘氨酸衍生物制备对金黄色葡萄球菌有抑菌和杀菌活性的抗菌剂的用途

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3697515A (en) * 1963-02-18 1972-10-10 Ciba Geigy Corp Process for splitting the 7-n-acyl group from cephalosporin compounds
JPS5672698A (en) * 1979-11-14 1981-06-16 Kyowa Hakko Kogyo Co Ltd Preparation of optically active cephalosporin analogue
NO155548C (no) * 1979-02-10 1987-04-15 Kyowa Hakko Kogyo Kk Fremgangsmaate til fremstilling av optisk aktive cefalosporin-analoger.
NO155547C (no) * 1979-02-10 1987-04-15 Kyowa Hakko Kogyo Kk Optisk aktive cefalosporin-analoge og salter derav samt fremgangsmaate for deres fremstilling.
JPS60174787A (ja) * 1984-02-21 1985-09-09 Kyowa Hakko Kogyo Co Ltd 3位置換カルバセフエム化合物
US4673737A (en) * 1985-08-02 1987-06-16 Harvard University 7-acylamino-(or 7-amino)-3-trifluoromethylsulfonyloxy-1-carba(1-dethia)-3-cephem-4-carboxylic acids and esters thereof

Also Published As

Publication number Publication date
GR3005920T3 (hu) 1993-06-07
DE3780909D1 (en) 1992-09-10
DE3780909T2 (de) 1993-03-04
HU200179B (en) 1990-04-28
AT388377B (de) 1989-06-12
PT85850B (en) 1990-01-12
PL268034A1 (en) 1988-09-01
KR880005125A (ko) 1988-06-28
FI874311A0 (fi) 1987-10-01
BG47034A3 (bg) 1990-04-16
CN87107149A (zh) 1988-05-18
IL84051A0 (en) 1988-03-31
AU591811B2 (en) 1989-12-14
ATA257587A (de) 1988-11-15
EP0266896B1 (en) 1992-08-05
PT85850A (en) 1987-11-01
ATE79119T1 (de) 1992-08-15
PL151703B1 (en) 1990-09-28
FI874311L (fi) 1988-04-04
AU7926987A (en) 1988-04-14
IE872646L (en) 1988-04-03
FI874311A7 (fi) 1988-04-04
NZ222015A (en) 1989-10-27
EP0266896A1 (en) 1988-05-11
ZA877398B (en) 1989-05-30
DK518487A (da) 1988-04-04
JPS6396186A (ja) 1988-04-27
DK518487D0 (da) 1987-10-02

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Legal Events

Date Code Title Description
HU90 Patent valid on 900628
HMM4 Cancellation of final prot. due to non-payment of fee