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HK1003031A1 - 縮合嘧啶衍生物及其用作血管緊張素ⅱ拮抗物之用途 - Google Patents

縮合嘧啶衍生物及其用作血管緊張素ⅱ拮抗物之用途 Download PDF

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Publication number
HK1003031A1
HK1003031A1 HK98102075A HK98102075A HK1003031A1 HK 1003031 A1 HK1003031 A1 HK 1003031A1 HK 98102075 A HK98102075 A HK 98102075A HK 98102075 A HK98102075 A HK 98102075A HK 1003031 A1 HK1003031 A1 HK 1003031A1
Authority
HK
Hong Kong
Prior art keywords
compound
formula
methyl
pyrimidin
pharmaceutically acceptable
Prior art date
Application number
HK98102075A
Other languages
German (de)
English (en)
French (fr)
Other versions
HK1003031B (zh
Inventor
Watson Ellingboe John
Nikaido Madelene
Franroz Bagli Jehan
Original Assignee
Wyeth
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US07/782,025 external-priority patent/US5149699A/en
Priority claimed from GB9207560A external-priority patent/GB2265899A/en
Priority claimed from US07/901,485 external-priority patent/US5256654A/en
Application filed by Wyeth filed Critical Wyeth
Publication of HK1003031A1 publication Critical patent/HK1003031A1/zh
Publication of HK1003031B publication Critical patent/HK1003031B/zh

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/04Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/14Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Heart & Thoracic Surgery (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
HK98102075.7A 1991-10-24 1998-03-12 縮合嘧啶衍生物及其用作血管緊張素ⅱ拮抗物之用途 HK1003031B (zh)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US782025 1991-10-24
US07/782,025 US5149699A (en) 1991-10-24 1991-10-24 Substituted pyridopyrimidines useful as antgiotensin II antagonists
GB9207560 1992-04-07
GB9207560A GB2265899A (en) 1992-04-07 1992-04-07 Substituted pyrimidines
US901485 1992-06-25
US07/901,485 US5256654A (en) 1991-10-24 1992-06-25 Substituted pyrrolopyrimidines, azepinopyrimidines and pyridopyrimidines useful as angiotensin II antagonists

Publications (2)

Publication Number Publication Date
HK1003031A1 true HK1003031A1 (zh) 1998-09-30
HK1003031B HK1003031B (zh) 1998-09-30

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Also Published As

Publication number Publication date
SK280292B6 (sk) 1999-11-08
FI103971B1 (fi) 1999-10-29
HU211915A9 (en) 1996-01-29
SK322192A3 (en) 1999-11-08
FI924397L (fi) 1993-04-25
HUT62893A (en) 1993-06-28
ATE161537T1 (de) 1998-01-15
DK0539086T3 (da) 1998-02-02
CN1072682A (zh) 1993-06-02
HU9203161D0 (en) 1992-12-28
GR3025926T3 (en) 1998-04-30
EP0539086A3 (en) 1993-06-16
NO924121D0 (no) 1992-10-23
JP3240192B2 (ja) 2001-12-17
CN1039324C (zh) 1998-07-29
EP0539086B1 (en) 1997-12-29
IL103436A0 (en) 1993-03-15
IL103436A (en) 1996-03-31
CA2080705C (en) 2002-12-03
CA2080705A1 (en) 1993-04-25
KR100286624B1 (ko) 2001-05-02
JPH05222039A (ja) 1993-08-31
AU653635B2 (en) 1994-10-06
ES2111617T3 (es) 1998-03-16
FI103971B (fi) 1999-10-29
FI924397A0 (fi) 1992-09-30
UA27748C2 (uk) 2000-10-16
KR930007949A (ko) 1993-05-20
SG47626A1 (en) 1998-04-17
EP0539086A2 (en) 1993-04-28
AU2607992A (en) 1993-04-29
LV12047A (lv) 1998-05-20
TW226375B (zh) 1994-07-11
NO924121L (no) 1993-04-26
CN1175414A (zh) 1998-03-11
DE69223734D1 (de) 1998-02-05
LV12047B (en) 1998-08-20
NO301275B1 (no) 1997-10-06
HU218786B (hu) 2000-12-28
DE69223734T2 (de) 1998-04-16

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HK1003031B (zh) 縮合嘧啶衍生物及其用作血管緊張素ⅱ拮抗物之用途
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Legal Events

Date Code Title Description
PF Patent in force
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20041014