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HK1050900A1 - 1,3-dihydro-2h-indol-2-one derivatives and their use as ligands for v1b or v1b and v1a arginine-vasopressin receptors - Google Patents

1,3-dihydro-2h-indol-2-one derivatives and their use as ligands for v1b or v1b and v1a arginine-vasopressin receptors Download PDF

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Publication number
HK1050900A1
HK1050900A1 HK03103183A HK03103183A HK1050900A1 HK 1050900 A1 HK1050900 A1 HK 1050900A1 HK 03103183 A HK03103183 A HK 03103183A HK 03103183 A HK03103183 A HK 03103183A HK 1050900 A1 HK1050900 A1 HK 1050900A1
Authority
HK
Hong Kong
Prior art keywords
indol
methyl
dihydro
dimethoxyphenyl
oxo
Prior art date
Application number
HK03103183A
Other languages
German (de)
English (en)
French (fr)
Chinese (zh)
Other versions
HK1050900B (en
Inventor
Roux Richard
Serradeil-Le Gal Claudine
Tonnerre Bernard
Wagnon Jean
Original Assignee
Sanofi-Aventis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi-Aventis filed Critical Sanofi-Aventis
Publication of HK1050900A1 publication Critical patent/HK1050900A1/xx
Publication of HK1050900B publication Critical patent/HK1050900B/xx

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    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404Indoles, e.g. pindolol
    • A61K31/405Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445Non condensed piperidines, e.g. piperocaine
    • A61K31/4523Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/33Heterocyclic compounds
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    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
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    • A61K31/33Heterocyclic compounds
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    • A61K31/535Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/53751,4-Oxazines, e.g. morpholine
    • A61K31/53771,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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    • A61K31/541Non-condensed thiazines containing further heterocyclic rings
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    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
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    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
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    • C07D209/02Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04Indoles; Hydrogenated indoles
    • C07D209/30Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32Oxygen atoms
    • C07D209/34Oxygen atoms in position 2

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Immunology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Pain & Pain Management (AREA)
  • Pulmonology (AREA)
  • Psychiatry (AREA)
  • Hematology (AREA)
  • Reproductive Health (AREA)
  • Obesity (AREA)
  • Pregnancy & Childbirth (AREA)
  • Gynecology & Obstetrics (AREA)
  • Ophthalmology & Optometry (AREA)
  • Rheumatology (AREA)
  • Hospice & Palliative Care (AREA)
  • Dermatology (AREA)
  • Transplantation (AREA)
  • Psychology (AREA)
  • Vascular Medicine (AREA)
HK03103183.8A 2000-01-25 2001-01-24 1,3-dihydro-2h-indol-2-one derivatives and their use as ligands for v1b or v1b and v1a arginine-vasopressin receptors HK1050900B (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR0000957 2000-01-25
FR0000957A FR2804114B1 (fr) 2000-01-25 2000-01-25 Nouveaux derives de 1,3-dihydro-2h-indol-2-one, un procede pour leur preparation et les compositions pharmaceutiques en contenant
PCT/FR2001/000226 WO2001055130A2 (fr) 2000-01-25 2001-01-24 Derives de 1,3-dihydro-2h-indol-2-one et leur utilisation en tant que ligands des recepteurs v1b ou v1b et v1a de l'arginine-vasopressine

Publications (2)

Publication Number Publication Date
HK1050900A1 true HK1050900A1 (en) 2003-07-11
HK1050900B HK1050900B (en) 2005-02-04

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Also Published As

Publication number Publication date
DE60103853D1 (de) 2004-07-22
RS50290B (sr) 2009-09-08
HU229081B1 (en) 2013-07-29
IL150539A (en) 2007-09-20
JP2003523351A (ja) 2003-08-05
SK286976B6 (sk) 2009-08-06
IL150539A0 (en) 2003-02-12
HUP0204242A2 (en) 2003-05-28
DE60103853T2 (de) 2005-04-28
NO20023510L (no) 2002-09-25
HUP0204242A3 (en) 2004-05-28
KR100689922B1 (ko) 2007-03-09
US20040209938A1 (en) 2004-10-21
MXPA02007259A (es) 2003-01-28
FR2804114B1 (fr) 2002-03-08
ATE269326T1 (de) 2004-07-15
TR200402344T4 (tr) 2004-12-21
CA2396814A1 (en) 2001-08-02
BG65796B1 (bg) 2009-12-31
IS6451A (is) 2002-06-28
JP3992498B2 (ja) 2007-10-17
WO2001055130A3 (fr) 2002-03-14
US20070004703A1 (en) 2007-01-04
SK10832002A3 (sk) 2003-03-04
BR0107807B1 (pt) 2014-02-25
FR2804114A1 (fr) 2001-07-27
SI1255751T1 (en) 2004-10-31
EA004628B1 (ru) 2004-06-24
ZA200205224B (en) 2004-03-09
AR027263A1 (es) 2003-03-19
IS2313B (is) 2007-11-15
HRP20020626B1 (en) 2009-04-30
CZ20022497A3 (cs) 2002-10-16
PL357553A1 (en) 2004-07-26
US20030114683A1 (en) 2003-06-19
NO20023510D0 (no) 2002-07-23
EP1255751B1 (fr) 2004-06-16
US6730695B2 (en) 2004-05-04
PT1255751E (pt) 2004-10-29
CZ300917B6 (cs) 2009-09-09
YU52302A (sh) 2006-05-25
CN1193025C (zh) 2005-03-16
EE200200409A (et) 2003-12-15
NO323607B1 (no) 2007-06-18
HRP20020626A2 (en) 2003-10-31
BG106947A (en) 2003-04-30
CA2396814C (en) 2007-07-10
UA74354C2 (uk) 2005-12-15
BR0107807A (pt) 2002-10-22
EP1255751A2 (fr) 2002-11-13
WO2001055130A2 (fr) 2001-08-02
DK1255751T3 (da) 2004-10-18
ES2222342T3 (es) 2005-02-01
AU778196B2 (en) 2004-11-18
AU3559401A (en) 2001-08-07
TWI283672B (en) 2007-07-11
KR20020067938A (ko) 2002-08-24
EA200200628A1 (ru) 2002-12-26
EE04779B1 (et) 2007-02-15
PL204160B1 (pl) 2009-12-31
MEP17308A (en) 2010-06-10
US7297692B2 (en) 2007-11-20
CN1404479A (zh) 2003-03-19
US7129240B2 (en) 2006-10-31

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Effective date: 20130124