GB1240207A - PROCESS FOR THE PREPARATION OF beta-LACTAMS - Google Patents
PROCESS FOR THE PREPARATION OF beta-LACTAMSInfo
- Publication number
- GB1240207A GB1240207A GB4182669A GB4182669A GB1240207A GB 1240207 A GB1240207 A GB 1240207A GB 4182669 A GB4182669 A GB 4182669A GB 4182669 A GB4182669 A GB 4182669A GB 1240207 A GB1240207 A GB 1240207A
- Authority
- GB
- United Kingdom
- Prior art keywords
- lactams
- hydrocarbyl
- aug
- beta
- preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 150000003952 β-lactams Chemical class 0.000 title 1
- 125000001183 hydrocarbyl group Chemical group 0.000 abstract 3
- 239000002253 acid Substances 0.000 abstract 2
- 239000003638 chemical reducing agent Substances 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- IGWGXZKGWFYOHE-UHFFFAOYSA-N 4,4-dimethylazetidin-2-one Chemical class CC1(C)CC(=O)N1 IGWGXZKGWFYOHE-UHFFFAOYSA-N 0.000 abstract 1
- BVKZGUZCCUSVTD-UHFFFAOYSA-M Bicarbonate Chemical compound OC([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-M 0.000 abstract 1
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 abstract 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
- 239000005864 Sulphur Substances 0.000 abstract 1
- 150000007513 acids Chemical class 0.000 abstract 1
- 150000008044 alkali metal hydroxides Chemical class 0.000 abstract 1
- 239000008346 aqueous phase Substances 0.000 abstract 1
- 125000002837 carbocyclic group Chemical group 0.000 abstract 1
- 230000003197 catalytic effect Effects 0.000 abstract 1
- 230000003301 hydrolyzing effect Effects 0.000 abstract 1
- 238000006386 neutralization reaction Methods 0.000 abstract 1
- 230000003472 neutralizing effect Effects 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D201/00—Preparation, separation, purification or stabilisation of unsubstituted lactams
- C07D201/02—Preparation of lactams
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
- C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
Abstract
1,240,207. # - Lactams. FARBWERKE HOECHST A:G. 21 Aug., 1969;[21 Aug., 1968], No. 418261/69. Heading C2C. # - Lactams of formula where R is C 1-2 substituted or unsubstituted hydrocarbyl, R<SP>1</SP>, R<SP>11</SP> and R<SP>111</SP> are H or C 1- 5 hydrocarbyl or two of R, R<SP>1</SP>., R<SP>11</SP> and R<SP>111</SP> are H or C 1-5 hydrocarbyl or two of R, R<SP>1</SP>, R<SP>11</SP> and R<SP>111</SP> may form a carbocyclic ring, are prepared by hydrolysing at a pH of 1-12 the corresponding # - lactam - N - sulphochloride in an aqueous phase in the presence of a catalytic amount of an oxyacid of sulphur which is a reducing agent, or a salt thereof, and neutralizing the acid produced. Suitable reducing agents are sulphurous, dithionous and pyrosulphurous acids and salts thereof, and neutralization may be effected with NH 3 or an alkali metal hydroxide, carbonate or bicarbonate. A solvent may be -used. Examples prepare 4 - phenyl-, 4 - methyl- and 4,4 - dimethylazetidinones - (2). Reference has been directed by the Comptroller to Specification 913,644.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19681795190 DE1795190B1 (en) | 1968-08-21 | 1968-08-21 | Process for the production of ss-lactams |
Publications (1)
Publication Number | Publication Date |
---|---|
GB1240207A true GB1240207A (en) | 1971-07-21 |
Family
ID=5708091
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB4182669A Expired GB1240207A (en) | 1968-08-21 | 1969-08-21 | PROCESS FOR THE PREPARATION OF beta-LACTAMS |
Country Status (8)
Country | Link |
---|---|
AT (1) | AT292655B (en) |
BE (1) | BE737781A (en) |
BR (1) | BR6911783D0 (en) |
CH (1) | CH520137A (en) |
DE (1) | DE1795190B1 (en) |
FR (1) | FR2016990A1 (en) |
GB (1) | GB1240207A (en) |
NL (1) | NL6912465A (en) |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE1086234B (en) * | 1958-03-22 | 1960-08-04 | Hoechst Ag | Process for the production of ª ‰ -lactams |
-
1968
- 1968-08-21 DE DE19681795190 patent/DE1795190B1/en active Pending
-
1969
- 1969-08-15 NL NL6912465A patent/NL6912465A/xx unknown
- 1969-08-19 AT AT793169A patent/AT292655B/en not_active IP Right Cessation
- 1969-08-19 CH CH1253369A patent/CH520137A/en not_active IP Right Cessation
- 1969-08-21 BE BE737781D patent/BE737781A/xx unknown
- 1969-08-21 BR BR21178369A patent/BR6911783D0/en unknown
- 1969-08-21 FR FR6928707A patent/FR2016990A1/fr not_active Withdrawn
- 1969-08-21 GB GB4182669A patent/GB1240207A/en not_active Expired
Also Published As
Publication number | Publication date |
---|---|
BE737781A (en) | 1970-02-23 |
NL6912465A (en) | 1970-02-24 |
CH520137A (en) | 1972-03-15 |
BR6911783D0 (en) | 1973-01-04 |
AT292655B (en) | 1971-09-10 |
FR2016990A1 (en) | 1970-05-15 |
DE1795190B1 (en) | 1972-05-31 |
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