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FR2318634A1 - Nouveaux derives phenoxy, leur procede de preparation et leur application en therapeutique - Google Patents

Nouveaux derives phenoxy, leur procede de preparation et leur application en therapeutique

Info

Publication number
FR2318634A1
FR2318634A1 FR7621727A FR7621727A FR2318634A1 FR 2318634 A1 FR2318634 A1 FR 2318634A1 FR 7621727 A FR7621727 A FR 7621727A FR 7621727 A FR7621727 A FR 7621727A FR 2318634 A1 FR2318634 A1 FR 2318634A1
Authority
FR
France
Prior art keywords
therapeutics
application
preparation process
phenoxy derivatives
new phenoxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7621727A
Other languages
English (en)
Other versions
FR2318634B1 (fr
Inventor
Laszlo Beregi
Pierre Hugon
Jacques Duhault
Michelle Boulanger
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Science Union et Cie
Original Assignee
Science Union et Cie
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Science Union et Cie filed Critical Science Union et Cie
Publication of FR2318634A1 publication Critical patent/FR2318634A1/fr
Application granted granted Critical
Publication of FR2318634B1 publication Critical patent/FR2318634B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/096—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D295/155—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
FR7621727A 1975-07-21 1976-07-16 Nouveaux derives phenoxy, leur procede de preparation et leur application en therapeutique Granted FR2318634A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB30392/75A GB1489711A (en) 1975-07-21 1975-07-21 1-phenoxyphenyl-piperazine derivatives process for their preparation and pharmaceutical compositions containing the

Publications (2)

Publication Number Publication Date
FR2318634A1 true FR2318634A1 (fr) 1977-02-18
FR2318634B1 FR2318634B1 (fr) 1979-06-29

Family

ID=10306953

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7621727A Granted FR2318634A1 (fr) 1975-07-21 1976-07-16 Nouveaux derives phenoxy, leur procede de preparation et leur application en therapeutique

Country Status (21)

Country Link
US (1) US4064245A (fr)
JP (1) JPS5225783A (fr)
AR (1) AR211273A1 (fr)
AT (1) AT350576B (fr)
AU (1) AU498329B2 (fr)
BE (1) BE844343A (fr)
CA (1) CA1085400A (fr)
CH (1) CH595368A5 (fr)
DE (1) DE2631885C2 (fr)
ES (1) ES450012A1 (fr)
FR (1) FR2318634A1 (fr)
GB (1) GB1489711A (fr)
GR (1) GR61593B (fr)
IE (1) IE43258B1 (fr)
MX (1) MX3413E (fr)
NL (1) NL162075C (fr)
OA (1) OA05385A (fr)
PH (1) PH12743A (fr)
PT (1) PT65380B (fr)
YU (1) YU163075A (fr)
ZA (1) ZA764305B (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3337788A4 (fr) * 2015-08-21 2019-03-27 Portola Pharmaceuticals, Inc. Modulateurs phénylpipérazine proprotéine convertase subtilisine/kexine de type 9 (pcsk9) et leur utilisation

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4210646A (en) * 1978-04-11 1980-07-01 Janssen Pharmaceutica N.V. Antimicrobial compositions containing 1-(aryloxyphenyl)piperazines
DE3235589A1 (de) * 1982-09-25 1984-03-29 Hoechst Ag, 6230 Frankfurt Benzylether von phenol-mannich-basen, verfahren zu ihrer herstellung, ihre verwendung sowie pharmazeutische praeparate auf basis dieser verbindungen, zwischenprodukte und verfahren zu deren herstellung
JPS63174868U (fr) * 1987-04-14 1988-11-14
UA81749C2 (uk) 2001-10-04 2008-02-11 Х. Луннбек А/С Фенілпіперазинові похідні як інгібітори зворотного захоплення серотоніну
CA2636929A1 (fr) * 2005-12-21 2007-07-12 Decode Genetics, Ehf Inhibiteurs de biaryl-azote-heterocycle de lta4h pour traiter l'inflammation
TW200932233A (en) * 2007-11-13 2009-08-01 Lundbeck & Co As H Therapeutic uses of compounds having combined SERT, 5-HT3 and 5-HT1a activity
EP3337564A4 (fr) 2015-08-21 2019-01-23 Portola Pharmaceuticals, Inc. Composition et procédés d'utilisation de petites molécules de type tétrahydroisoquinoline pour se lier à pcsk9 et moduler l'activité protéique de pcsk9
EP3337497B1 (fr) 2015-08-21 2023-07-12 SRX Cardio, LLC Composition et procédés d'utilisation de nouveaux petits composés organiques de phénylalanine pour moduler directement l'activité de la protéine pcsk9
US20190119236A1 (en) 2016-02-23 2019-04-25 Portola Pharmaceuticals, Inc. Compounds for binding proprotein convertase subtilisin/kexin type 9 (pcsk9)
IL315313A (en) * 2018-08-24 2024-10-01 Xeniopro GmbH Aromatic molecules for use in the treatment of pathological conditions
US12115154B2 (en) 2020-12-16 2024-10-15 Srx Cardio, Llc Compounds for the modulation of proprotein convertase subtilisin/kexin type 9 (PCSK9)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3337788A4 (fr) * 2015-08-21 2019-03-27 Portola Pharmaceuticals, Inc. Modulateurs phénylpipérazine proprotéine convertase subtilisine/kexine de type 9 (pcsk9) et leur utilisation

Also Published As

Publication number Publication date
NL7608007A (nl) 1977-01-25
IE43258L (en) 1977-01-21
BE844343A (fr) 1977-01-20
ATA534376A (de) 1978-11-15
GR61593B (en) 1978-12-02
NL162075B (nl) 1979-11-15
DE2631885C2 (de) 1982-07-15
PT65380B (fr) 1978-01-19
ES450012A1 (es) 1977-07-16
IE43258B1 (en) 1981-01-14
OA05385A (fr) 1981-02-28
AU1603976A (en) 1978-01-26
GB1489711A (en) 1977-10-26
YU163075A (en) 1982-05-31
US4064245A (en) 1977-12-20
PT65380A (fr) 1976-08-01
DE2631885A1 (de) 1977-02-10
MX3413E (es) 1980-11-07
AR211273A1 (es) 1977-11-15
AT350576B (de) 1978-06-15
JPS5225783A (en) 1977-02-25
CH595368A5 (fr) 1978-02-15
PH12743A (en) 1979-08-09
CA1085400A (fr) 1980-09-09
AU498329B2 (en) 1979-03-01
ZA764305B (en) 1977-07-27
NL162075C (nl) 1980-04-15
FR2318634B1 (fr) 1979-06-29
JPS558504B2 (fr) 1980-03-04

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ST Notification of lapse