ES462076A1 - A PROCEDURE FOR THE PREPARATION OF D-HOMOSTEROIDS. - Google Patents
A PROCEDURE FOR THE PREPARATION OF D-HOMOSTEROIDS.Info
- Publication number
- ES462076A1 ES462076A1 ES462076A ES462076A ES462076A1 ES 462076 A1 ES462076 A1 ES 462076A1 ES 462076 A ES462076 A ES 462076A ES 462076 A ES462076 A ES 462076A ES 462076 A1 ES462076 A1 ES 462076A1
- Authority
- ES
- Spain
- Prior art keywords
- homosteroids
- procedure
- preparation
- fluorine
- chlorine atom
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 150000000795 D-homosteroids Chemical class 0.000 title abstract 2
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 abstract 3
- 229910052801 chlorine Inorganic materials 0.000 abstract 3
- 125000001309 chloro group Chemical group Cl* 0.000 abstract 3
- 229910052731 fluorine Inorganic materials 0.000 abstract 3
- 239000011737 fluorine Substances 0.000 abstract 3
- 239000001257 hydrogen Substances 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 125000004423 acyloxy group Chemical group 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J63/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by expansion of only one ring by one or two atoms
- C07J63/008—Expansion of ring D by one atom, e.g. D homo steroids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Rheumatology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Pain & Pain Management (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Steroid Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Un procedimiento para la preparación de D-homoesteroides de la fórmula general: ***(Ver fórmula ) en donde R6reresenta un átomo de hidrógeno, flúor o cloro o un grupo metílico; R9representa un átomo de hidrógeno, flúor o cloro; R17arepresenta un grupo de hidroxilo o aciloxilo con la salvedad de que, en donde R6 representa un átomo de nitrógeno en un compuesto 17a-hidroxílico, R9 debe representar un átomo de flúor o cloro.A procedure for the preparation of D-homosteroids of the general formula: ***(See formula) where R6represents a hydrogen, fluorine or chlorine atom or a methyl group; R9 represents a hydrogen, fluorine or chlorine atom; R17a represents a hydroxyl or acyloxy group with the proviso that, where R6 represents a nitrogen atom in a 17a-hydroxy compound, R9 must represent a fluorine or chlorine atom.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AT656076A AT356301B (en) | 1976-09-03 | 1976-09-03 | METHOD FOR THE PRODUCTION OF NEW D-HOMOSTEROIDS |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES462076A1 true ES462076A1 (en) | 1978-11-01 |
Family
ID=3587531
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES462076A Expired ES462076A1 (en) | 1976-09-03 | 1977-09-02 | A PROCEDURE FOR THE PREPARATION OF D-HOMOSTEROIDS. |
| ES469573A Expired ES469573A1 (en) | 1976-09-03 | 1978-05-08 | A PROCEDURE FOR THE PREPARATION OF D-HOMOSTEROIDS. |
| ES469574A Expired ES469574A1 (en) | 1976-09-03 | 1978-05-08 | A PROCEDURE FOR THE PREPARATION OF D-HOMOSTEROIDS. |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES469573A Expired ES469573A1 (en) | 1976-09-03 | 1978-05-08 | A PROCEDURE FOR THE PREPARATION OF D-HOMOSTEROIDS. |
| ES469574A Expired ES469574A1 (en) | 1976-09-03 | 1978-05-08 | A PROCEDURE FOR THE PREPARATION OF D-HOMOSTEROIDS. |
Country Status (30)
| Country | Link |
|---|---|
| JP (1) | JPS5910680B2 (en) |
| AR (1) | AR220320A1 (en) |
| AT (1) | AT356301B (en) |
| AU (1) | AU516174B2 (en) |
| BE (1) | BE858354A (en) |
| CA (1) | CA1098897A (en) |
| CH (4) | CH629827A5 (en) |
| DE (1) | DE2738363A1 (en) |
| DK (1) | DK140947B (en) |
| ES (3) | ES462076A1 (en) |
| FI (1) | FI57600C (en) |
| FR (1) | FR2363580A1 (en) |
| GB (1) | GB1586504A (en) |
| GR (1) | GR73039B (en) |
| HK (1) | HK26484A (en) |
| HU (2) | HU184769B (en) |
| IE (1) | IE45671B1 (en) |
| IL (1) | IL52831A (en) |
| IT (1) | IT1085032B (en) |
| LU (1) | LU78064A1 (en) |
| MC (1) | MC1166A1 (en) |
| MY (1) | MY8500293A (en) |
| NL (1) | NL182314C (en) |
| NO (1) | NO145621C (en) |
| NZ (1) | NZ185046A (en) |
| PH (1) | PH14434A (en) |
| PT (1) | PT66983B (en) |
| SE (1) | SE440783B (en) |
| YU (2) | YU40009B (en) |
| ZA (1) | ZA775192B (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1188616A (en) * | 1981-06-11 | 1985-06-11 | Hoffmann-La Roche Limited | Pharmaceutical preparations |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH571018A5 (en) * | 1972-03-29 | 1975-12-31 | Hoffmann La Roche | |
| NO140672C (en) * | 1973-03-28 | 1979-10-17 | Hoffmann La Roche | ANALOGICAL PROCEDURES FOR THE MANUFACTURE OF NEW ANTI-INFLAMMATORY EFFECTIVE STEROIDS |
| DE2349023A1 (en) * | 1973-09-26 | 1975-04-10 | Schering Ag | NEW D-HOMO-STEROIDS |
| CH601351A5 (en) * | 1973-09-26 | 1978-07-14 | Hoffmann La Roche | |
| DE2349022A1 (en) * | 1973-09-26 | 1975-04-10 | Schering Ag | NEW D-HOMO-STEROIDS |
| DE2442615A1 (en) * | 1974-09-04 | 1976-03-18 | Schering Ag | NEW D-HOMO-STEROIDS |
-
1976
- 1976-09-03 AT AT656076A patent/AT356301B/en not_active IP Right Cessation
-
1977
- 1977-08-09 CH CH973377A patent/CH629827A5/en not_active IP Right Cessation
- 1977-08-22 YU YU2009/77A patent/YU40009B/en unknown
- 1977-08-25 DE DE19772738363 patent/DE2738363A1/en active Granted
- 1977-08-26 IL IL52831A patent/IL52831A/en unknown
- 1977-08-26 ZA ZA00775192A patent/ZA775192B/en unknown
- 1977-08-29 AU AU28304/77A patent/AU516174B2/en not_active Expired
- 1977-08-29 IE IE1800/77A patent/IE45671B1/en unknown
- 1977-08-29 NZ NZ185046A patent/NZ185046A/en unknown
- 1977-08-30 CA CA285,723A patent/CA1098897A/en not_active Expired
- 1977-08-31 IT IT27147/77A patent/IT1085032B/en active
- 1977-08-31 PH PH20179A patent/PH14434A/en unknown
- 1977-08-31 HU HU80306A patent/HU184769B/en unknown
- 1977-08-31 HU HU77HO2011A patent/HU176255B/en unknown
- 1977-08-31 NL NLAANVRAGE7709585,A patent/NL182314C/en not_active IP Right Cessation
- 1977-09-01 FR FR7726562A patent/FR2363580A1/en active Granted
- 1977-09-01 LU LU78064A patent/LU78064A1/xx unknown
- 1977-09-01 PT PT66983A patent/PT66983B/en unknown
- 1977-09-01 AR AR269060A patent/AR220320A1/en active
- 1977-09-01 FI FI772599A patent/FI57600C/en not_active IP Right Cessation
- 1977-09-01 MC MC771258A patent/MC1166A1/en unknown
- 1977-09-02 SE SE7709916A patent/SE440783B/en not_active IP Right Cessation
- 1977-09-02 GB GB36737/77A patent/GB1586504A/en not_active Expired
- 1977-09-02 NO NO773057A patent/NO145621C/en unknown
- 1977-09-02 JP JP52105054A patent/JPS5910680B2/en not_active Expired
- 1977-09-02 ES ES462076A patent/ES462076A1/en not_active Expired
- 1977-09-02 DK DK393277AA patent/DK140947B/en not_active IP Right Cessation
- 1977-09-02 BE BE180635A patent/BE858354A/en not_active IP Right Cessation
-
1978
- 1978-05-08 ES ES469573A patent/ES469573A1/en not_active Expired
- 1978-05-08 ES ES469574A patent/ES469574A1/en not_active Expired
-
1979
- 1979-09-01 GR GR54275A patent/GR73039B/el unknown
-
1981
- 1981-09-16 CH CH598281A patent/CH629828A5/en not_active IP Right Cessation
- 1981-09-16 CH CH598381A patent/CH629829A5/en not_active IP Right Cessation
- 1981-09-16 CH CH598481A patent/CH629830A5/en not_active IP Right Cessation
-
1982
- 1982-10-08 YU YU2277/82A patent/YU40089B/en unknown
-
1984
- 1984-03-22 HK HK264/84A patent/HK26484A/en unknown
-
1985
- 1985-12-30 MY MY293/85A patent/MY8500293A/en unknown
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