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ES2510216B1 - CAPABLE MICROORGANISM OF CONVERTING ELAGIC ACID AND ELAGITANINS IN UROLITINES AND USE OF THE SAME - Google Patents

CAPABLE MICROORGANISM OF CONVERTING ELAGIC ACID AND ELAGITANINS IN UROLITINES AND USE OF THE SAME Download PDF

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Publication number
ES2510216B1
ES2510216B1 ES201330400A ES201330400A ES2510216B1 ES 2510216 B1 ES2510216 B1 ES 2510216B1 ES 201330400 A ES201330400 A ES 201330400A ES 201330400 A ES201330400 A ES 201330400A ES 2510216 B1 ES2510216 B1 ES 2510216B1
Authority
ES
Spain
Prior art keywords
urolithin
urolitines
elagitanins
converting
same
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
ES201330400A
Other languages
Spanish (es)
Other versions
ES2510216A1 (en
Inventor
Francisco TOMÁS BARBERÁN
María Victoria SELMA GARCÍA
David Beltrán Riquelme
Juan Carlos ESPÍN DE GEA
Rocío GARCÍA VILLALBA
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Consejo Superior de Investigaciones Cientificas CSIC
Original Assignee
Consejo Superior de Investigaciones Cientificas CSIC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Consejo Superior de Investigaciones Cientificas CSIC filed Critical Consejo Superior de Investigaciones Cientificas CSIC
Priority to ES201330400A priority Critical patent/ES2510216B1/en
Priority to PCT/ES2014/070207 priority patent/WO2014147280A1/en
Publication of ES2510216A1 publication Critical patent/ES2510216A1/en
Application granted granted Critical
Publication of ES2510216B1 publication Critical patent/ES2510216B1/en
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6888—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms
    • C12Q1/689—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms for bacteria
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/02—Oxygen as only ring hetero atoms
    • C12P17/06—Oxygen as only ring hetero atoms containing a six-membered hetero ring, e.g. fluorescein

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Physics & Mathematics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

La presente invención se refiere a la identificación por primera vez de microorganismos de origen gastrointestinal humano, que pueden producir urolitinas, a procedimientos de producción de dichos compuestos, al uso de dichos compuestos así producidos en la elaboración de formulaciones alimenticias, farmacéuticas, complementos dietéticos o alimentarios y alimentos funcionales, así como la elaboración de composiciones probióticas mediante la incorporación de microorganismos productores de urolitinas y a un método de aislamiento, de detección y de cuantificación de microorganismos productores de urolitinas basado en el uso de un fragmento de ADN capaz de detectar específicamente los microorganismos productores de urolitinas.The present invention relates to the identification for the first time of microorganisms of human gastrointestinal origin, which can produce urolithins, to production processes of said compounds, to the use of said compounds thus produced in the preparation of food, pharmaceutical, dietary supplements or food and functional foods, as well as the development of probiotic compositions by incorporating urolithin-producing microorganisms and a method of isolation, detection and quantification of urolithin-producing microorganisms based on the use of a DNA fragment capable of specifically detecting urolithin producing microorganisms.

Description



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Claims (1)



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ES201330400A 2013-03-20 2013-03-20 CAPABLE MICROORGANISM OF CONVERTING ELAGIC ACID AND ELAGITANINS IN UROLITINES AND USE OF THE SAME Expired - Fee Related ES2510216B1 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
ES201330400A ES2510216B1 (en) 2013-03-20 2013-03-20 CAPABLE MICROORGANISM OF CONVERTING ELAGIC ACID AND ELAGITANINS IN UROLITINES AND USE OF THE SAME
PCT/ES2014/070207 WO2014147280A1 (en) 2013-03-20 2014-03-20 Micro-organism that can convert ellagic acid and ellagitannins into urolithins and use of same

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES201330400A ES2510216B1 (en) 2013-03-20 2013-03-20 CAPABLE MICROORGANISM OF CONVERTING ELAGIC ACID AND ELAGITANINS IN UROLITINES AND USE OF THE SAME

Publications (2)

Publication Number Publication Date
ES2510216A1 ES2510216A1 (en) 2014-10-20
ES2510216B1 true ES2510216B1 (en) 2015-10-27

Family

ID=51579346

Family Applications (1)

Application Number Title Priority Date Filing Date
ES201330400A Expired - Fee Related ES2510216B1 (en) 2013-03-20 2013-03-20 CAPABLE MICROORGANISM OF CONVERTING ELAGIC ACID AND ELAGITANINS IN UROLITINES AND USE OF THE SAME

Country Status (2)

Country Link
ES (1) ES2510216B1 (en)
WO (1) WO2014147280A1 (en)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2017014154A (en) * 2015-07-01 2017-01-19 公立大学法人岡山県立大学 Hyaluronic acid production promoter containing urolithins
JP6799767B2 (en) * 2015-07-07 2020-12-16 公立大学法人岡山県立大学 Melanin production inhibitor containing urolithins
JP6760685B2 (en) * 2016-04-19 2020-09-23 株式会社ダイセル Manufacturing method of urolithins
ES2925648T3 (en) 2016-12-26 2022-10-19 Daicel Corp Production method of urolithins
WO2018155485A1 (en) 2017-02-23 2018-08-30 株式会社ダイセル Novel microorganism and production method for urolithins using same
WO2019130448A1 (en) 2017-12-26 2019-07-04 株式会社ダイセル Method for producing urolithins
JP7044574B2 (en) * 2018-01-25 2022-03-30 株式会社ダイセル New lactase
JP2019180283A (en) * 2018-04-06 2019-10-24 株式会社ダイセル Method for producing urolithin
WO2019212997A1 (en) * 2018-04-30 2019-11-07 Rejuvenation Therapeutics Compositions and methods for biosynthetic preparation of urolithin compounds and use thereof
PT3891267T (en) * 2018-11-05 2024-07-04 Marvelbiome Inc Microbial compositions comprising ellagitannin and methods of use
JP7661226B2 (en) 2019-07-25 2025-04-14 株式会社ダイセル An enzyme that dehydroxylates the hydroxyl groups of urolithins
US11730778B2 (en) * 2019-09-24 2023-08-22 Access Business Group International Llc Method of increasing the level and production of metabolized phytonutrients in a subject
CA3158191A1 (en) * 2019-12-10 2021-06-17 Northeastern University Microbial compositions and methods for treatment and detection of disease
WO2022045257A1 (en) 2020-08-28 2022-03-03 株式会社ダイセル Enzyme dehydroxylating hydroxyl group at 9-position of urolithin compound
EP4112064B1 (en) 2021-06-28 2024-07-24 ASC REGENITY Limited Skin care nutraceutical composition

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2646177T3 (en) * 2006-04-26 2017-12-12 The Regents Of The University Of California Therapeutic uses of urolithins
DK3372228T3 (en) * 2010-12-23 2025-05-26 Amazentis Sa NON-THERAPEUTIC APPROACH TO INCREASE OR MAINTAIN MITOCHONDRAL FUNCTION

Also Published As

Publication number Publication date
ES2510216A1 (en) 2014-10-20
WO2014147280A1 (en) 2014-09-25

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