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ES2129733T3 - Procedimiento de preparacion de analogos de la lignina y productos de partida para estos. - Google Patents

Procedimiento de preparacion de analogos de la lignina y productos de partida para estos.

Info

Publication number
ES2129733T3
ES2129733T3 ES95117572T ES95117572T ES2129733T3 ES 2129733 T3 ES2129733 T3 ES 2129733T3 ES 95117572 T ES95117572 T ES 95117572T ES 95117572 T ES95117572 T ES 95117572T ES 2129733 T3 ES2129733 T3 ES 2129733T3
Authority
ES
Spain
Prior art keywords
lower alkyl
chem
formula
ring
substituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES95117572T
Other languages
English (en)
Inventor
Sachio Mori
Shozo Takechi
Shiro Kida
Takuji Mizui
Teruhisa Ichihashi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Shionogi and Co Ltd
Original Assignee
Shionogi and Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shionogi and Co Ltd filed Critical Shionogi and Co Ltd
Application granted granted Critical
Publication of ES2129733T3 publication Critical patent/ES2129733T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
    • C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
    • C07C69/738—Esters of keto-carboxylic acids or aldehydo-carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/76—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring
    • C07C69/94—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring of polycyclic hydroxy carboxylic acids, the hydroxy groups and the carboxyl groups of which are bound to carbon atoms of six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
    • C07D307/88—Benzo [c] furans; Hydrogenated benzo [c] furans with one oxygen atom directly attached in position 1 or 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
    • C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D317/18—Radicals substituted by singly bound oxygen or sulfur atoms
    • C07D317/22—Radicals substituted by singly bound oxygen or sulfur atoms etherified
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/70—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with ring systems containing two or more relevant rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/10—1,4-Dioxanes; Hydrogenated 1,4-dioxanes
    • C07D319/14—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems
    • C07D319/22—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one naphthalene or hydrogenated naphthalene ring system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/62—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/64—Oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Furan Compounds (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
  • Steroid Compounds (AREA)
  • Compounds Of Unknown Constitution (AREA)

Abstract

UN PROCESO PARA PREPARAR UN COMPUESTO REPRESENTADO POR LA FORMULA (I) DONDE R{SUP,1} ES UN GRUPO ALKILO INFERIOR, CICLOALKILO INFERIOR , CICLOALKILINFERIOR ALKILO INFERIOR , ARILO INFERIOR O ARALKILO INFERIOR QUE ESTA OPCIONALMENTE SUSTITUIDO; R{SUP,2} ES UN GRUPO REPRESENTADO POR LA FORMULA: COOR'': (DNDE R'' ES UN ARLAKILO O ALKILO INFERIOR QUE ESTA OPCIONALMENTE SUSTITUIDO) ALKILO INFERIOR, O ALKILO INFERIOR HALOGENADO, O R{SUP,1} Y R{SUP,2} JUNTO CON UN GRUPO CARBONILO, FORMAN UN ANILLO CICLOHEXANONA, R{SUP,3} ES UN GRUPO FENILO OPCIONALMENTE SUSTITUIDO; Y, UN ANILLO A ES UN NUCLEO DE BENCENO QUE ESTA OPCIONALMENTE SUSTITUIDO, O UN ANILLO HETEROCICLICO S0 O QUE ESTA OPCIONALMENTE SUSTITUIDO; DICHO PROCESO SE CARACTERIZA POR UN COMPUESTO DE LACTONA REPRESENTADO POR LA FORMULA (VI), EN LA QUE R{SUP,3} Y EL ANILLO A SON COMO SE DEFINEN ANTERIORMENTE, SE PERMITE QUE REACCIONEN CON UN COMPUESTO DE UNA FORMULA (VII) EN LA QUE R{SUP,1} Y R{SUP,2} SON COMO SE DEFINEN ANTERIORMENTE EN PRESENCIA DEUNA BASE, Y DESPUES EL COMPUESTO RESULTANTE ES SOMETIDO A DESHIDRATACION Y LOS COMPUESTOS SE USAN EN EL PROCESO.
ES95117572T 1991-10-17 1992-10-15 Procedimiento de preparacion de analogos de la lignina y productos de partida para estos. Expired - Lifetime ES2129733T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP29811991 1991-10-17

Publications (1)

Publication Number Publication Date
ES2129733T3 true ES2129733T3 (es) 1999-06-16

Family

ID=17855421

Family Applications (2)

Application Number Title Priority Date Filing Date
ES92921331T Expired - Lifetime ES2091488T3 (es) 1991-10-17 1992-10-15 Analogo de lignano, su produccion y medicamento hipolipidemico.
ES95117572T Expired - Lifetime ES2129733T3 (es) 1991-10-17 1992-10-15 Procedimiento de preparacion de analogos de la lignina y productos de partida para estos.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES92921331T Expired - Lifetime ES2091488T3 (es) 1991-10-17 1992-10-15 Analogo de lignano, su produccion y medicamento hipolipidemico.

Country Status (12)

Country Link
US (4) US5420333A (es)
EP (2) EP0597107B1 (es)
JP (1) JP2839805B2 (es)
KR (1) KR100252428B1 (es)
AT (2) ATE175954T1 (es)
DE (2) DE69228262D1 (es)
DK (2) DK0597107T3 (es)
ES (2) ES2091488T3 (es)
GR (1) GR3020461T3 (es)
HU (1) HU211296A9 (es)
TW (1) TW209215B (es)
WO (1) WO1993008155A1 (es)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100277242B1 (ko) * 1993-04-16 2001-02-01 시오노 요시히코 리그난계 화합물의 제조방법
FR2707980B1 (fr) * 1993-07-20 1995-09-01 Adir Nouveaux cyclohept[b]indoles et cyclooct[b]indoles, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent.
AU2353095A (en) * 1994-06-22 1996-01-15 Shionogi & Co., Ltd. Process for producing phthalide compound
ID18046A (id) * 1996-08-20 1998-02-19 Takeda Chemical Industries Ltd Senyawa siklik campuran, pembuatan dan penngunaannya.
JP2002529409A (ja) * 1998-11-12 2002-09-10 アルテオン インコーポレーテッド グルコース及び脂質低下化合物類
KR100352269B1 (ko) * 1999-10-08 2002-09-12 한국생명공학연구원 저밀도 지질 단백질에 대해 항산화 활성을 갖는 리그난계 화합물
FR2800738B1 (fr) 1999-11-04 2002-02-08 Corning Sa Naphtopyranes ayant un substituant perfluoroalkyle en position 5, preparation et compositions et matrices (co)polymeres les renfermant
US6770024B1 (en) * 2000-03-28 2004-08-03 Stony Brook Surgical Innovations, Inc. Implantable counterpulsation cardiac assist device
TWI241195B (en) * 2000-04-10 2005-10-11 Shionogi & Co Preventive agent for bile acidic diarrhea
US20030153513A1 (en) * 2000-08-01 2003-08-14 Teruo Shiomi Preventives or remedies for obesity or fatty liver
JPWO2004033411A1 (ja) * 2002-10-08 2006-02-09 塩野義製薬株式会社 エノンエステルの製造法
US7152611B2 (en) * 2002-12-30 2006-12-26 International Tape Partners, Llc Coated multifilament dental devices overcoated with imbedded particulate
GB0307918D0 (en) 2003-04-05 2003-05-14 Astrazeneca Ab Therapeutic use
EP4137137A1 (en) 2010-05-26 2023-02-22 Satiogen Pharmaceuticals, Inc. Bile acid recycling inhibitors and satiogens for treatment of diabetes, obesity, and inflammatory gastrointestinal conditions
CA2853285C (en) 2011-10-28 2020-05-05 Lumena Pharmaceuticals, Inc. Bile acid recycling inhibitors for treatment of pediatric cholestatic liver diseases
BR112014010228B1 (pt) 2011-10-28 2020-09-29 Lumena Pharmaceuticals Llc Uso de inibidores de reciclagem de ácido biliar para o tratamento de hipercolemia e doença hepática colestática
WO2014144485A1 (en) 2013-03-15 2014-09-18 Lumena Pharmaceuticals, Inc. Bile acid recycling inhibitors for treatment of barrett's esophagus and gastroesophageal reflux disease
MX2015013193A (es) 2013-03-15 2016-04-15 Lumena Pharmaceuticals Inc Inhibidores del reciclaje de acidos biliares para el tratamiento de colangitis esclerosante primaria y enfermedad inflamatoria intestinal.
KR20210137467A (ko) 2019-02-12 2021-11-17 미룸 파마슈티컬스, 인크. 담즙 염 유출 펌프 결핍을 갖는 환자에서 asbti에 대한 유전자형 및 용량-의존성 반응

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NO170760C (no) * 1985-01-10 1992-12-02 Tanabe Seiyaku Co Analogifremgangsmaate for fremstilling av terapeutisk aktive nafthalenderivater
JPS6310746A (ja) * 1986-07-01 1988-01-18 Tanabe Seiyaku Co Ltd ナフタレン誘導体
JPH0372422A (ja) * 1989-05-16 1991-03-27 Tanabe Seiyaku Co Ltd 抗脂血剤

Also Published As

Publication number Publication date
EP0597107A4 (en) 1994-02-03
ATE175954T1 (de) 1999-02-15
DE69211994D1 (de) 1996-08-08
US5731455A (en) 1998-03-24
JP2839805B2 (ja) 1998-12-16
ES2091488T3 (es) 1996-11-01
EP0597107A1 (en) 1994-05-18
US5502216A (en) 1996-03-26
EP0701991A1 (en) 1996-03-20
DK0701991T3 (da) 1999-09-13
TW209215B (es) 1993-07-11
EP0701991B1 (en) 1999-01-20
KR100252428B1 (ko) 2000-04-15
KR930703236A (ko) 1993-11-29
JPH05310634A (ja) 1993-11-22
DE69211994T2 (de) 1997-02-20
DK0597107T3 (da) 1996-07-29
DE69228262D1 (de) 1999-03-04
US5420333A (en) 1995-05-30
US5449814A (en) 1995-09-12
EP0597107B1 (en) 1996-07-03
HU211296A9 (en) 1995-11-28
GR3020461T3 (en) 1996-10-31
ATE139990T1 (de) 1996-07-15
WO1993008155A1 (en) 1993-04-29

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