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ES2094132T3 - Uso de derivados de xantina contra la ulcera peptica. - Google Patents

Uso de derivados de xantina contra la ulcera peptica.

Info

Publication number
ES2094132T3
ES2094132T3 ES90115456T ES90115456T ES2094132T3 ES 2094132 T3 ES2094132 T3 ES 2094132T3 ES 90115456 T ES90115456 T ES 90115456T ES 90115456 T ES90115456 T ES 90115456T ES 2094132 T3 ES2094132 T3 ES 2094132T3
Authority
ES
Spain
Prior art keywords
peptica
ulcera
xantina
derivatives against
alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES90115456T
Other languages
English (en)
Inventor
Toshizo Tanaka
Shoryo Hayashi
Yuko Morioka
Ulrich Dr Gebert
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis KK
Original Assignee
Hoechst Japan Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Japan Ltd filed Critical Hoechst Japan Ltd
Application granted granted Critical
Publication of ES2094132T3 publication Critical patent/ES2094132T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Steroid Compounds (AREA)

Abstract

AGENTES TERAPEUTICOS PARA EL TRATAMIENTO DE ENFERMEDADES DE ULCERA PEPTICA QUE CONTIENEN COMO INGREDIENTE ACTIVO AL MENOS UN COMPUESTO DE FORMULA GENERAL I, EN DONDE UNO DE LOS R1 Y R3 ES (EN DONDE M ES 1-5, R4 REPRESENTA UN GRUPO ALQUILO C1-C4); EL RESTANTE DE R1 O R3 ES HIDROGENO, ALQUENILO C3-C6 O ALQUILO C1-C8, EL CUAL PUEDE ESTAR SUSTITUIDO CON HASTA 2 GRUPOS HIDROXILO O UN GRUPO ALCOXILO C1-C4; Y R2 ES ALQUILO C1-C4.
ES90115456T 1989-08-16 1990-08-11 Uso de derivados de xantina contra la ulcera peptica. Expired - Lifetime ES2094132T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP21018789 1989-08-16

Publications (1)

Publication Number Publication Date
ES2094132T3 true ES2094132T3 (es) 1997-01-16

Family

ID=16585226

Family Applications (1)

Application Number Title Priority Date Filing Date
ES90115456T Expired - Lifetime ES2094132T3 (es) 1989-08-16 1990-08-11 Uso de derivados de xantina contra la ulcera peptica.

Country Status (18)

Country Link
US (1) US5109003A (es)
EP (1) EP0413278B1 (es)
JP (1) JP2977242B2 (es)
KR (1) KR910004620A (es)
AT (1) ATE144900T1 (es)
AU (1) AU624987B2 (es)
CA (1) CA2023310A1 (es)
DD (1) DD298051A5 (es)
DE (1) DE69029069T2 (es)
DK (1) DK0413278T3 (es)
ES (1) ES2094132T3 (es)
GR (1) GR3021569T3 (es)
HU (1) HU207518B (es)
IE (1) IE902954A1 (es)
IL (1) IL95377A (es)
NZ (1) NZ234896A (es)
PT (1) PT95007A (es)
ZA (1) ZA906446B (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0570831A2 (de) * 1992-05-20 1993-11-24 Hoechst Aktiengesellschaft Verwendung von Xanthinderivaten zur Behandlung von Nervenschädigungen nach Unterbrechung der Blutzirkulation
US5354756A (en) * 1993-01-12 1994-10-11 Cell Therapeutics, Inc. Olefin-substituted long chain xanthine compounds
DE4411660A1 (de) * 1994-04-05 1995-10-12 Hoechst Ag Verwendung von Xanthinderivaten zur Reduktion der pathologischen Hyperreagibilität eosinophiler Granulozyten, neue Xanthinverbindungen und Verfahren zu deren Herstellung
US7122207B2 (en) * 1998-05-22 2006-10-17 Bristol-Myers Squibb Company High drug load acid labile pharmaceutical composition

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3525801A1 (de) * 1985-07-19 1987-01-22 Hoechst Ag Tertiaere hydroxyalkylxanthine, verfahren zu ihrer herstellung, die sie enthaltenden arzneimittel und ihre verwendung
JPS63225317A (ja) * 1986-10-06 1988-09-20 Hoechst Japan Kk 抗消化性潰瘍剤
IL106861A (en) * 1986-12-31 1997-02-18 Hoechst Roussel Pharma Pentoxifylline metabolites and pharmaceutical formulations containing them for inhibiting the activity of interleukin-1 and leukocyte-derived cytokines
JP2661666B2 (ja) * 1988-02-19 1997-10-08 ヘキスト薬品工業株式会社 抗消化性潰瘍剤

Also Published As

Publication number Publication date
IL95377A (en) 1994-08-26
EP0413278A2 (en) 1991-02-20
KR910004620A (ko) 1991-03-29
ZA906446B (en) 1991-05-29
EP0413278B1 (en) 1996-11-06
IE902954A1 (en) 1991-02-27
GR3021569T3 (en) 1997-02-28
HU905000D0 (en) 1991-01-28
DE69029069D1 (de) 1996-12-12
PT95007A (pt) 1991-04-18
HUT54688A (en) 1991-03-28
JP2977242B2 (ja) 1999-11-15
JPH03163019A (ja) 1991-07-15
HU207518B (en) 1993-04-28
AU6101890A (en) 1991-02-21
AU624987B2 (en) 1992-06-25
CA2023310A1 (en) 1991-02-17
EP0413278A3 (en) 1992-05-06
NZ234896A (en) 1993-10-26
US5109003A (en) 1992-04-28
DE69029069T2 (de) 1997-04-10
IL95377A0 (en) 1991-06-30
DK0413278T3 (da) 1997-04-07
ATE144900T1 (de) 1996-11-15
DD298051A5 (de) 1992-02-06

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