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EP3434671A4 - Sultam compound and application method thereof - Google Patents

Sultam compound and application method thereof Download PDF

Info

Publication number
EP3434671A4
EP3434671A4 EP17769434.6A EP17769434A EP3434671A4 EP 3434671 A4 EP3434671 A4 EP 3434671A4 EP 17769434 A EP17769434 A EP 17769434A EP 3434671 A4 EP3434671 A4 EP 3434671A4
Authority
EP
European Patent Office
Prior art keywords
application method
sultam compound
sultam
compound
application
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP17769434.6A
Other languages
German (de)
French (fr)
Other versions
EP3434671B1 (en
EP3434671A1 (en
Inventor
Li Zhu
Xiaowei DUAN
Liguang DAI
Zhao Yang
Yanqing Yang
Hui Zhang
Yuandong Hu
Yong Peng
Yongxin Han
Rui Zhao
Xin Tian
Shanchun WANG
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Centaurus Biopharma Co Ltd
Chia Tai Tianqing Pharmaceutical Group Co Ltd
Lianyungang Runzhong Pharmaceutical Co Ltd
Original Assignee
Centaurus Biopharma Co Ltd
Chia Tai Tianqing Pharmaceutical Group Co Ltd
Lianyungang Runzhong Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Centaurus Biopharma Co Ltd, Chia Tai Tianqing Pharmaceutical Group Co Ltd, Lianyungang Runzhong Pharmaceutical Co Ltd filed Critical Centaurus Biopharma Co Ltd
Publication of EP3434671A1 publication Critical patent/EP3434671A1/en
Publication of EP3434671A4 publication Critical patent/EP3434671A4/en
Application granted granted Critical
Publication of EP3434671B1 publication Critical patent/EP3434671B1/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D275/00—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings
    • C07D275/02—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D275/00—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings
    • C07D275/02—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings not condensed with other rings
    • C07D275/03—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/433—Thidiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
    • C07D285/01—Five-membered rings
    • C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
    • C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
    • C07D285/10—1,2,5-Thiadiazoles; Hydrogenated 1,2,5-thiadiazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
EP17769434.6A 2016-03-22 2017-03-22 Sultam compound and application method thereof Active EP3434671B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN201610165138 2016-03-22
PCT/CN2017/077612 WO2017162157A1 (en) 2016-03-22 2017-03-22 Sultam compound and application method thereof

Publications (3)

Publication Number Publication Date
EP3434671A1 EP3434671A1 (en) 2019-01-30
EP3434671A4 true EP3434671A4 (en) 2019-08-14
EP3434671B1 EP3434671B1 (en) 2020-10-21

Family

ID=59899279

Family Applications (1)

Application Number Title Priority Date Filing Date
EP17769434.6A Active EP3434671B1 (en) 2016-03-22 2017-03-22 Sultam compound and application method thereof

Country Status (15)

Country Link
US (1) US11111240B2 (en)
EP (1) EP3434671B1 (en)
JP (1) JP6880166B2 (en)
KR (1) KR102389985B1 (en)
CN (2) CN109071471B (en)
AU (1) AU2017239318B2 (en)
BR (1) BR112018069504B1 (en)
CA (1) CA3018649A1 (en)
DK (1) DK3434671T5 (en)
ES (1) ES2842448T3 (en)
PT (1) PT3434671T (en)
RU (1) RU2741915C9 (en)
TW (1) TWI729094B (en)
WO (1) WO2017162157A1 (en)
ZA (1) ZA201806379B (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL3686191T3 (en) * 2017-09-22 2023-03-06 Chia Tai Tianqing Pharmaceutical Group Co., Ltd. Crystalline sulfamide compound
WO2021028791A1 (en) * 2019-08-09 2021-02-18 Alembic Pharmaceuticals Limited An improved process of preparation of ivosidenib
WO2023226964A1 (en) * 2022-05-26 2023-11-30 Danatlas Pharmaceuticals Co., Ltd. Heterocyclic derivatives, compositions and uses thereof
WO2024131727A1 (en) * 2022-12-19 2024-06-27 正大天晴药业集团股份有限公司 Use of sultam compound in treating biliary tract cancer
WO2024205311A1 (en) * 2023-03-31 2024-10-03 Avelos Therapeutics Inc. Substituted sultam compound derivatives and their pharmaceutical use

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012009678A1 (en) * 2010-07-16 2012-01-19 Agios Pharmaceuticals, Inc. Therapeutically active compositions and their method of use
WO2013107405A1 (en) * 2012-01-19 2013-07-25 Agios Pharmaceuticals, Inc. Therapeutically active compounds and their methods of use

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100455899B1 (en) * 2000-10-20 2004-11-08 주식회사 티지 바이오텍 Isocitrate dehydrogenase, a gene thereof and a use for treatment of obesity, hyperlipidemia and fatty liver or lipid biosynthesis
US9474779B2 (en) 2012-01-19 2016-10-25 Agios Pharmaceuticals, Inc. Therapeutically active compositions and their methods of use
WO2015010297A1 (en) * 2013-07-25 2015-01-29 Agios Pharmaceuticals, Inc. Therapeutically active compounds and their methods of use

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012009678A1 (en) * 2010-07-16 2012-01-19 Agios Pharmaceuticals, Inc. Therapeutically active compositions and their method of use
WO2013107405A1 (en) * 2012-01-19 2013-07-25 Agios Pharmaceuticals, Inc. Therapeutically active compounds and their methods of use

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of WO2017162157A1 *

Also Published As

Publication number Publication date
RU2018136487A (en) 2020-04-22
BR112018069504A2 (en) 2019-01-29
DK3434671T3 (en) 2021-01-25
RU2741915C9 (en) 2021-03-31
AU2017239318B2 (en) 2020-08-20
TWI729094B (en) 2021-06-01
KR20180128935A (en) 2018-12-04
AU2017239318A1 (en) 2018-10-18
BR112018069504B1 (en) 2023-12-26
RU2018136487A3 (en) 2020-04-24
US20210047314A1 (en) 2021-02-18
RU2741915C2 (en) 2021-01-29
CN113666922A (en) 2021-11-19
DK3434671T5 (en) 2021-03-29
KR102389985B1 (en) 2022-04-22
EP3434671B1 (en) 2020-10-21
CN109071471A (en) 2018-12-21
TW201736354A (en) 2017-10-16
PT3434671T (en) 2020-12-24
CN109071471B (en) 2021-05-07
JP2019513819A (en) 2019-05-30
US11111240B2 (en) 2021-09-07
JP6880166B2 (en) 2021-06-02
EP3434671A1 (en) 2019-01-30
ES2842448T3 (en) 2021-07-14
CA3018649A1 (en) 2017-09-28
WO2017162157A1 (en) 2017-09-28
ZA201806379B (en) 2021-03-31

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