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EP2953958A4 - Highly selective nucleic acid amplification primers - Google Patents

Highly selective nucleic acid amplification primers

Info

Publication number
EP2953958A4
EP2953958A4 EP14748774.8A EP14748774A EP2953958A4 EP 2953958 A4 EP2953958 A4 EP 2953958A4 EP 14748774 A EP14748774 A EP 14748774A EP 2953958 A4 EP2953958 A4 EP 2953958A4
Authority
EP
European Patent Office
Prior art keywords
nucleic acid
acid amplification
highly selective
amplification primers
selective nucleic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP14748774.8A
Other languages
German (de)
French (fr)
Other versions
EP2953958B1 (en
EP2953958A1 (en
Inventor
Salvatore Marras
Diana Vargas-Gold
Sanjay Tyagi
Fred Russell Kramer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Rutgers State University of New Jersey
Original Assignee
Rutgers State University of New Jersey
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=51300164&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EP2953958(A4) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Rutgers State University of New Jersey filed Critical Rutgers State University of New Jersey
Priority to EP18156307.3A priority Critical patent/EP3346016B1/en
Publication of EP2953958A1 publication Critical patent/EP2953958A1/en
Publication of EP2953958A4 publication Critical patent/EP2953958A4/en
Application granted granted Critical
Publication of EP2953958B1 publication Critical patent/EP2953958B1/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/26—Preparation of nitrogen-containing carbohydrates
    • C12P19/28—N-glycosides
    • C12P19/30—Nucleotides
    • C12P19/34—Polynucleotides, e.g. nucleic acids, oligoribonucleotides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844—Nucleic acid amplification reactions
    • C12Q1/6858—Allele-specific amplification
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844—Nucleic acid amplification reactions
    • C12Q1/686—Polymerase chain reaction [PCR]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2525/00—Reactions involving modified oligonucleotides, nucleic acids, or nucleotides
    • C12Q2525/10—Modifications characterised by
    • C12Q2525/161—Modifications characterised by incorporating target specific and non-target specific sites
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2525/00—Reactions involving modified oligonucleotides, nucleic acids, or nucleotides
    • C12Q2525/10—Modifications characterised by
    • C12Q2525/191—Modifications characterised by incorporating an adaptor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2535/00—Reactions characterised by the assay type for determining the identity of a nucleotide base or a sequence of oligonucleotides
    • C12Q2535/125—Allele specific primer extension
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2535/00—Reactions characterised by the assay type for determining the identity of a nucleotide base or a sequence of oligonucleotides
    • C12Q2535/131—Allele specific probes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
EP14748774.8A 2013-02-07 2014-02-07 Highly selective nucleic acid amplification primers Active EP2953958B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP18156307.3A EP3346016B1 (en) 2013-02-07 2014-02-07 Highly selective nucleic acid amplification primers

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361762117P 2013-02-07 2013-02-07
PCT/US2014/015351 WO2014124290A1 (en) 2013-02-07 2014-02-07 Highly selective nucleic acid amplification primers

Related Child Applications (2)

Application Number Title Priority Date Filing Date
EP18156307.3A Division EP3346016B1 (en) 2013-02-07 2014-02-07 Highly selective nucleic acid amplification primers
EP18156307.3A Division-Into EP3346016B1 (en) 2013-02-07 2014-02-07 Highly selective nucleic acid amplification primers

Publications (3)

Publication Number Publication Date
EP2953958A1 EP2953958A1 (en) 2015-12-16
EP2953958A4 true EP2953958A4 (en) 2016-08-17
EP2953958B1 EP2953958B1 (en) 2018-04-11

Family

ID=51300164

Family Applications (2)

Application Number Title Priority Date Filing Date
EP18156307.3A Active EP3346016B1 (en) 2013-02-07 2014-02-07 Highly selective nucleic acid amplification primers
EP14748774.8A Active EP2953958B1 (en) 2013-02-07 2014-02-07 Highly selective nucleic acid amplification primers

Family Applications Before (1)

Application Number Title Priority Date Filing Date
EP18156307.3A Active EP3346016B1 (en) 2013-02-07 2014-02-07 Highly selective nucleic acid amplification primers

Country Status (11)

Country Link
US (3) US9909159B2 (en)
EP (2) EP3346016B1 (en)
JP (1) JP6544861B2 (en)
KR (2) KR102351434B1 (en)
CN (2) CN110195097A (en)
AU (1) AU2014214725B2 (en)
CA (2) CA3096478C (en)
IL (2) IL240347B (en)
SG (1) SG11201506146TA (en)
WO (1) WO2014124290A1 (en)
ZA (1) ZA201505637B (en)

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US10801070B2 (en) 2013-11-25 2020-10-13 The Broad Institute, Inc. Compositions and methods for diagnosing, evaluating and treating cancer
WO2015085147A1 (en) 2013-12-05 2015-06-11 The Broad Institute Inc. Polymorphic gene typing and somatic change detection using sequencing data
KR20160101073A (en) 2013-12-20 2016-08-24 더 브로드 인스티튜트, 인코퍼레이티드 Combination therapy with neoantigen vaccine
EP3234193B1 (en) 2014-12-19 2020-07-15 Massachusetts Institute of Technology Molecular biomarkers for cancer immunotherapy
EP3757211A1 (en) 2014-12-19 2020-12-30 The Broad Institute, Inc. Methods for profiling the t-cell-receptor repertoire
RU2733754C2 (en) 2015-05-20 2020-10-06 Те Брод Инститьют Инк. Common neoantigens
CN105274096A (en) * 2015-09-07 2016-01-27 中国人民解放军第三军医大学第一附属医院 Bridge type fluorescent probe with bridge type sequence zone doping into mismatched bases and application and method
CA3020165A1 (en) 2016-04-07 2017-10-12 Rutgers, The State University Of New Jersey Multiplex nucleic acid assay methods capable of detecting closely related alleles, and reagents therefor
EP3458613B1 (en) * 2016-05-18 2022-09-14 Integrated Nano-Technologies, Inc. Method for detection of a pcr product
CN106399484B (en) * 2016-08-31 2020-03-24 中国人民解放军第三军医大学第一附属医院 Double-bubble fluorescent probe and application and kit thereof
US11434540B2 (en) * 2016-11-15 2022-09-06 Arizona Board Of Regents On Behalf Of Arizona State University Ultraspecific nucleic acid sensors for low-cost liquid biopsies
US11549149B2 (en) 2017-01-24 2023-01-10 The Broad Institute, Inc. Compositions and methods for detecting a mutant variant of a polynucleotide
JP7062681B2 (en) * 2017-03-20 2022-05-06 イルミナ インコーポレイテッド Methods and Compositions for Preparing Nucleic Acid Libraries
AU2018272848B2 (en) 2017-05-23 2022-03-31 Rutgers, The State University Of New Jersey Target mediated
WO2019140298A1 (en) * 2018-01-12 2019-07-18 Natera, Inc. Novel primers and uses thereof
WO2019150414A1 (en) * 2018-01-30 2019-08-08 学校法人 慶應義塾 Method for detecting nucleic acid
CN110964814B (en) * 2018-09-30 2024-05-03 迈克生物股份有限公司 Primers, compositions and methods for nucleic acid sequence variation detection
KR20220069111A (en) 2019-10-02 2022-05-26 러트거즈,더스테이트유니버시티오브뉴저지 Assay methods and kits for detecting rare sequence variants
CN111647650B (en) * 2020-07-06 2023-06-27 河南赛诺特生物技术有限公司 Primer, primer probe composition and kit for detecting V600E mutation of human B-raf gene
CN112575072B (en) * 2020-12-29 2021-12-31 苏州科贝生物技术有限公司 Primer pair and kit for detecting BRAF gene V600E mutation in plasma free DNA
US20230112648A1 (en) * 2021-09-17 2023-04-13 Homology Medicines, Inc. Non-naturally occurring polyadenylation elements and methods of use thereof
CN116121453B (en) * 2022-11-11 2024-08-20 重庆浦济生命科技有限公司 Improved structure of high-sensitivity fluorescent PCR detection primer and probe and application thereof
WO2024170770A1 (en) 2023-02-16 2024-08-22 Asecud Sa High nucleic acid sequence discrimination using a multifaceted nucleic acid molecule
CN117778575A (en) * 2023-12-25 2024-03-29 深圳海普洛斯医学检验实验室 TaqMan probe for detecting SNV locus and application thereof

Citations (3)

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US5866336A (en) * 1996-07-16 1999-02-02 Oncor, Inc. Nucleic acid amplification oligonucleotides with molecular energy transfer labels and methods based thereon
JP4528885B1 (en) * 2009-06-29 2010-08-25 株式会社東芝 Sample analysis method and assay kit used therefor
WO2013123552A1 (en) * 2012-02-20 2013-08-29 Speedx Pty Ltd Detection of nucleic acids

Family Cites Families (14)

* Cited by examiner, † Cited by third party
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US6207379B1 (en) 1998-09-11 2001-03-27 One Lambda Method for amplification of DNA
US6277607B1 (en) 1999-05-24 2001-08-21 Sanjay Tyagi High specificity primers, amplification methods and kits
US7198897B2 (en) 2001-12-19 2007-04-03 Brandeis University Late-PCR
WO2006095941A1 (en) 2005-03-05 2006-09-14 Seegene, Inc. Processes using dual specificity oligonucleotide and dual specificity oligonucleotide
KR100977186B1 (en) 2005-03-05 2010-08-23 주식회사 씨젠 Processes Using Dual Specificity Oligonucleotide and Dual Specificity Oligonucleotide
CA2919210C (en) * 2005-06-07 2019-03-05 Luminex Corporation Methods for detection and typing of nucleic acids
KR100860619B1 (en) 2006-02-23 2008-09-29 주식회사 씨젠 Oligonucleotides for Detecting Nucleic Acids of Pathogen Causing Sexually Transmitted Diseases
KR100881924B1 (en) * 2007-03-14 2009-02-04 주식회사 씨젠 Method for Detecting Nucleotide Variations Using Labelled Primers
ES2610616T3 (en) 2009-03-26 2017-04-28 Xiamen Amoy Diagnostics Co., Ltd Primer with loop conformation used in the amplification of nucleic acids and the use thereof
WO2011027966A2 (en) 2009-09-03 2011-03-10 Seegene, Inc. Td probe and its uses
JP5938348B2 (en) * 2009-10-23 2016-06-22 ルミネックス コーポレーション Amplification primers containing non-standard bases for increased reaction specificity
KR20110050327A (en) * 2009-11-07 2011-05-13 주식회사 씨젠 T h d primer target detection
JP5822843B2 (en) * 2009-12-21 2015-11-24 シージーン アイエヌシー TSG primer target detection
JP2014507149A (en) 2011-02-14 2014-03-27 スウィフト バイオサイエンシーズ， インコーポレイテッド Polynucleotide primers and probes

Patent Citations (3)

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Publication number Priority date Publication date Assignee Title
US5866336A (en) * 1996-07-16 1999-02-02 Oncor, Inc. Nucleic acid amplification oligonucleotides with molecular energy transfer labels and methods based thereon
JP4528885B1 (en) * 2009-06-29 2010-08-25 株式会社東芝 Sample analysis method and assay kit used therefor
WO2013123552A1 (en) * 2012-02-20 2013-08-29 Speedx Pty Ltd Detection of nucleic acids

Non-Patent Citations (1)

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Title
See also references of WO2014124290A1 *

Also Published As

Publication number Publication date
EP3346016B1 (en) 2019-10-02
IL264555A (en) 2019-02-28
WO2014124290A1 (en) 2014-08-14
US20180216151A1 (en) 2018-08-02
AU2014214725B2 (en) 2018-04-05
NZ710851A (en) 2020-11-27
SG11201506146TA (en) 2015-09-29
CA3096478C (en) 2021-06-22
AU2014214725A1 (en) 2015-08-20
EP2953958B1 (en) 2018-04-11
US20150361475A1 (en) 2015-12-17
CN110195097A (en) 2019-09-03
US10815512B2 (en) 2020-10-27
KR102222546B1 (en) 2021-03-08
IL240347B (en) 2019-02-28
CA2900259A1 (en) 2014-08-14
US11111515B2 (en) 2021-09-07
KR20210024220A (en) 2021-03-04
ZA201505637B (en) 2016-07-27
KR20150115932A (en) 2015-10-14
US20210164009A1 (en) 2021-06-03
CN105102467A (en) 2015-11-25
CN105102467B (en) 2019-01-22
EP3346016A1 (en) 2018-07-11
IL240347A0 (en) 2015-09-24
KR102351434B1 (en) 2022-01-17
IL264555B (en) 2021-10-31
EP2953958A1 (en) 2015-12-16
CA3096478A1 (en) 2014-08-14
CA2900259C (en) 2020-12-29
JP2016506748A (en) 2016-03-07
JP6544861B2 (en) 2019-07-17
US9909159B2 (en) 2018-03-06

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