EP2214674A4 - Inhibitors of anti-apoptotic proteins - Google Patents

Inhibitors of anti-apoptotic proteins

Info

Publication number: EP2214674A4
Authority: EP; European Patent Office
Prior art keywords: inhibitors; apoptotic proteins; apoptotic; proteins
Prior art date: 2007-10-19
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Withdrawn

Application number

EP08839150A

Other languages

German (de)

French (fr)

Other versions

EP2214674A1 (en

Inventor

Maurizio Pellecchia

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Sanford Burnham Prebys Medical Discovery Institute

Original Assignee

Sanford Burnham Prebys Medical Discovery Institute

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2007-10-19

Filing date

2008-10-17

Publication date

2011-03-30

2008-10-17 Application filed by Sanford Burnham Prebys Medical Discovery Institute filed Critical Sanford Burnham Prebys Medical Discovery Institute

2010-08-11 Publication of EP2214674A1 publication Critical patent/EP2214674A1/en

2011-03-30 Publication of EP2214674A4 publication Critical patent/EP2214674A4/en

Status Withdrawn legal-status Critical Current

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/36—Sulfur atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Diabetes (AREA)
Physical Education & Sports Medicine (AREA)
Neurology (AREA)
Endocrinology (AREA)
Dermatology (AREA)
Pulmonology (AREA)
Immunology (AREA)
Orthopedic Medicine & Surgery (AREA)
Obesity (AREA)
Neurosurgery (AREA)
Urology & Nephrology (AREA)
Biomedical Technology (AREA)
Rheumatology (AREA)
Oncology (AREA)
Hematology (AREA)
Emergency Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Thiazole And Isothizaole Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

EP08839150A 2007-10-19 2008-10-17 Inhibitors of anti-apoptotic proteins Withdrawn EP2214674A4 (en)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US98146607P	2007-10-19	2007-10-19
US5712908P	2008-05-29	2008-05-29
PCT/US2008/080383 WO2009052440A1 (en)	2007-10-19	2008-10-17	Inhibitors of anti-apoptotic proteins

Publications (2)

Publication Number	Publication Date
EP2214674A1 EP2214674A1 (en)	2010-08-11
EP2214674A4 true EP2214674A4 (en)	2011-03-30

Family

ID=40567809

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EP08839150A Withdrawn EP2214674A4 (en)	2007-10-19	2008-10-17	Inhibitors of anti-apoptotic proteins

Country Status (7)

Country	Link
US (1)	US20090124675A1 (en)
EP (1)	EP2214674A4 (en)
JP (1)	JP2011500726A (en)
CN (1)	CN101896184A (en)
AU (1)	AU2008311824A1 (en)
CA (1)	CA2703723A1 (en)
WO (1)	WO2009052440A1 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
SG10201402346UA (en) *	2009-05-19	2014-10-30	Vivia Biotech Sl	Methods for providing personalized medicine tests ex vivo for hematological neoplasms
US10195213B2 (en)	2015-03-13	2019-02-05	Unity Biotechnology, Inc.	Chemical entities that kill senescent cells for use in treating age-related disease
CN108721302A (en) *	2018-06-29	2018-11-02	佛山科学技术学院	A kind of compound medicament composition and application thereof

Citations (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP2003313168A (en) *	2002-04-18	2003-11-06	Kirin Brewery Co Ltd	COMPOUND HAVING Bcl-2 INHIBITING ACTIVITY AND METHOD FOR SCREENING THE COMPOUND

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS5740478A (en) *	1980-08-22	1982-03-06	Ono Pharmaceut Co Ltd	Rhodanine derivative, its preparation and aldose reductase inhibitor containing rhodanine derivative
IT1311922B1 (en) *	1999-04-13	2002-03-20	Nicox Sa	PHARMACEUTICAL COMPOUNDS.
US6506755B2 (en) *	2000-02-03	2003-01-14	Hoffmann-La Roche Inc.	Thiazolidinecarboxyl acids
US7714005B2 (en) *	2004-12-22	2010-05-11	The Ohio State University Research Foundation	Small molecule Bcl-xL/Bcl-2 binding inhibitors

2008
- 2008-10-17 JP JP2010530163A patent/JP2011500726A/en not_active Withdrawn
- 2008-10-17 WO PCT/US2008/080383 patent/WO2009052440A1/en active Application Filing
- 2008-10-17 EP EP08839150A patent/EP2214674A4/en not_active Withdrawn
- 2008-10-17 CN CN200880120783XA patent/CN101896184A/en active Pending
- 2008-10-17 AU AU2008311824A patent/AU2008311824A1/en not_active Abandoned
- 2008-10-17 CA CA2703723A patent/CA2703723A1/en not_active Abandoned
- 2008-10-17 US US12/253,921 patent/US20090124675A1/en not_active Abandoned

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP2003313168A (en) *	2002-04-18	2003-11-06	Kirin Brewery Co Ltd	COMPOUND HAVING Bcl-2 INHIBITING ACTIVITY AND METHOD FOR SCREENING THE COMPOUND

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
DATABASE CAPLUS [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; 1966, KOPIICHUK, I. I.: "Synthesis and properties of rhodanines, obtained from valine", XP002622177, retrieved from STN Database accession no. 1966:429429 *
DATABASE CAPLUS [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; KAMINS'KII, D. V. ET AL: "5-Ylidene-2-thioxo-4-thiazolidone-3-succinic acids and their derivatives: synthesis, anticancer activity, and QSAR analysis", XP002622179, retrieved from STN Database accession no. 2007:157739 *
DATABASE CAPLUS [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; March 2007 (2007-03-01), LIU, CHANG-SHAN ET AL: "Effects of epalrestat on aldose reductase activity, ultrastructural pathology and apoptosis in the renal tissues of diabetic rats", XP002622176, retrieved from STN Database accession no. 2007:510633 *
FRESNEAU, PATRICK ET AL: "Synthesis, Activity, and Molecular Modeling of New 2,4-Dioxo-5-(naphthylmethylene)-3-thiazolidineacetic Acids and 2-Thioxo Analogs as Potent Aldose Reductase Inhibitors", JOURNAL OF MEDICINAL CHEMISTRY , 41(24), 4706-4715 CODEN: JMCMAR; ISSN: 0022-2623, 1998, XP002622178 *

Also Published As

Publication number	Publication date
US20090124675A1 (en)	2009-05-14
JP2011500726A (en)	2011-01-06
AU2008311824A1 (en)	2009-04-23
CN101896184A (en)	2010-11-24
CA2703723A1 (en)	2009-04-23
WO2009052440A1 (en)	2009-04-23
EP2214674A1 (en)	2010-08-11

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Legal Events

Date	Code	Title	Description
2010-07-09	PUAI	Public reference made under article 153(3) epc to a published international application that has entered the european phase	Free format text: ORIGINAL CODE: 0009012
2010-08-11	17P	Request for examination filed	Effective date: 20100518
2010-08-11	AK	Designated contracting states	Kind code of ref document: A1 Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MT NL NO PL PT RO SE SI SK TR
2010-08-11	AX	Request for extension of the european patent	Extension state: AL BA MK RS
2011-01-26	DAX	Request for extension of the european patent (deleted)
2011-03-23	RIC1	Information provided on ipc code assigned before grant	Ipc: C07D 277/36 20060101ALI20110214BHEP Ipc: A61K 31/535 20060101AFI20090514BHEP
2011-03-30	A4	Supplementary search report drawn up and despatched	Effective date: 20110224
2012-03-09	STAA	Information on the status of an ep patent application or granted ep patent	Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN
2012-04-11	18D	Application deemed to be withdrawn	Effective date: 20110927