EP0391999A4 - Peptidyl inhibitors of the initiation of coagulation - Google Patents

Peptidyl inhibitors of the initiation of coagulation

Info

Publication number: EP0391999A4
Authority: EP; European Patent Office
Prior art keywords: coagulation; initiation; peptidyl inhibitors; peptidyl; inhibitors
Prior art date: 1988-09-23
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Withdrawn

Application number

EP19890911204

Other versions

EP0391999A1 (en

Inventor

Michael G. Pepe

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Dendreon Pharmaceuticals LLC

Original Assignee

Corvas Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1988-09-23

Filing date

1989-09-22

Publication date

1991-03-13

1989-09-22 Application filed by Corvas Inc filed Critical Corvas Inc

1990-10-17 Publication of EP0391999A1 publication Critical patent/EP0391999A1/en

1991-03-13 Publication of EP0391999A4 publication Critical patent/EP0391999A4/en

Status Withdrawn legal-status Critical Current

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/6437—Coagulation factor VIIa (3.4.21.21)
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/55—Protease inhibitors
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
- C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
- C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21021—Coagulation factor VIIa (3.4.21.21)

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Genetics & Genomics (AREA)
Bioinformatics & Cheminformatics (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Wood Science & Technology (AREA)
Zoology (AREA)
Biochemistry (AREA)
General Engineering & Computer Science (AREA)
Gastroenterology & Hepatology (AREA)
Biomedical Technology (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Epidemiology (AREA)
Veterinary Medicine (AREA)
Biophysics (AREA)
Pharmacology & Pharmacy (AREA)
Immunology (AREA)
Biotechnology (AREA)
Microbiology (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)

EP19890911204 1988-09-23 1989-09-22 Peptidyl inhibitors of the initiation of coagulation Withdrawn EP0391999A4 (en)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date
US24881788A	1988-09-23	1988-09-23
US248817		1988-09-23
US40859589A	1989-09-20	1989-09-20
US408595		1989-09-20

Publications (2)

Publication Number	Publication Date
EP0391999A1 EP0391999A1 (en)	1990-10-17
EP0391999A4 true EP0391999A4 (en)	1991-03-13

Family

ID=26939597

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EP19890911204 Withdrawn EP0391999A4 (en)	1988-09-23	1989-09-22	Peptidyl inhibitors of the initiation of coagulation

Country Status (3)

Country	Link
EP (1)	EP0391999A4 (en)
AU (1)	AU4338689A (en)
WO (1)	WO1990003390A1 (en)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5190919A (en) *	1989-11-13	1993-03-02	Board Of Regents, The University Of Texas System	Antihemostatic factor vii peptides
DE4007902A1 (en) *	1990-03-13	1991-09-19	Behringwerke Ag	SYNTHETIC PEPTIDES CONTAINING SEQUENCES OF FACTOR VIIA AND ITS USE
US5861374A (en) *	1991-02-28	1999-01-19	Novo Nordisk A/S	Modified Factor VII
US5997864A (en)	1995-06-07	1999-12-07	Novo Nordisk A/S	Modified factor VII
US5788965A (en) *	1991-02-28	1998-08-04	Novo Nordisk A/S	Modified factor VII
US5833982A (en)	1991-02-28	1998-11-10	Zymogenetics, Inc.	Modified factor VII
US5817788A (en) *	1991-02-28	1998-10-06	Zymogenetics, Inc.	Modified factor VII
US6039944A (en) *	1992-02-28	2000-03-21	Zymogenetics, Inc.	Modified Factor VII
DE69413817T2 (en) *	1993-06-18	1999-06-10	Nycomed Imaging As, Oslo	FACTOR VII PEPTIDE
GB9425380D0 (en) *	1994-12-15	1995-02-15	Nycomed Pharma As	Peptides
GB9425381D0 (en) *	1994-12-15	1995-02-15	Nycomed Pharma As	Peptides
WO1999013063A1 (en) *	1997-09-09	1999-03-18	Nycomed Imaging As	Factor vii fragments and analogs thereof and their use in the treatment of blood clottng disorders
WO1999013062A1 (en) *	1997-09-09	1999-03-18	Nycomed Imaging As	Factors vii fragments and analogs thereof and their use in the treatment of blood clotting disorders
EP0987274A1 (en) *	1998-09-15	2000-03-22	Hoechst Marion Roussel Deutschland GmbH	Factor VIIa Inhibitors
IL147269A0 (en)	1999-07-02	2002-08-14	Genentech Inc	FVIIa ANTAGONISTS
US7164002B2 (en)	2002-02-06	2007-01-16	Genentech, Inc.	FVIIa antagonists
GB0916576D0 (en) *	2009-09-22	2009-10-28	Malmsten Nils M	Polypeptides and uses thereof
CA3010310C (en)	2016-01-15	2022-11-22	Rigshospitalet	A positron-emitting 18-f labelled factor viia (fviia) imaging agent and method of use thereof
MA46864A (en)	2016-11-17	2021-04-28	Minerva Imaging Aps	FACTOR VII INHIBITED BY THE ACTIVE SITE MARKED BY 177-LU

1989
- 1989-09-22 AU AU43386/89A patent/AU4338689A/en not_active Abandoned
- 1989-09-22 EP EP19890911204 patent/EP0391999A4/en not_active Withdrawn
- 1989-09-22 WO PCT/US1989/004140 patent/WO1990003390A1/en not_active Application Discontinuation

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
No further relevant documents have been disclosed. *
See also references of WO9003390A1 *

Also Published As

Publication number	Publication date
EP0391999A1 (en)	1990-10-17
WO1990003390A1 (en)	1990-04-05
AU4338689A (en)	1990-04-18

Publication	Publication Date	Title
EP0391999A4 (en)	1991-03-13	Peptidyl inhibitors of the initiation of coagulation
GB2226325B (en)	1992-01-15	Polymerization of butadiene
NZ231662A (en)	1992-08-26	Dipeptide derivatives having renin-inhibitory action
IL90218A0 (en)	1989-12-15	Retroviral protease inhibitors
AU7168091A (en)	1991-07-24	Mercaptocycloacyl aminoacid endopeptidase inhibitors
SG53193G (en)	1993-06-25	Deodorizer for refrigerators of the like
GB8830234D0 (en)	1989-02-22	Peroxycarboxylic acids
HU893412D0 (en)	1991-05-28	Inhibitors of interleucin-1
JPS6447799A (en)	1989-02-22	Tissue factor inhibitor
PH27413A (en)	1993-06-21	7-oxabicycloheptyl substituted heterocyclic amide prostaglandin analogs useful in the treatment of thrombotic and vasopastic
ZA899558B (en)	1990-08-29	Retroviral protease inhibitors
GB2241563B (en)	1993-09-29	The initiation of propellants
IL92777A0 (en)	1990-09-17	Method and agent for the determination of maleimide groups
HU906389D0 (en)	1991-04-29	New alpha-glycosidase inhibitors
GB2251402B (en)	1993-06-23	Procedure for the manufacture of contour-stable objects
IL92618A0 (en)	1990-08-31	Dipeptide derivatives having an enzyme inhibitor action
GB8813374D0 (en)	1988-11-16	Initiation methods
IL95380A0 (en)	1991-06-30	Peptidyl difluorodiol renin inhibitors
EP0411395A3 (en)	1991-11-13	Use of ace inhibitors for atherosclerosis-prophylaxis
AU2885689A (en)	1989-08-03	Novel proteins derived from human alpha2-plasmin inhibitor orproteins similar thereto
ZA904825B (en)	1991-04-24	Inhibition of potato-sprouting
GB8815245D0 (en)	1988-08-03	New tissue plasminogen activator
ZA892627B (en)	1989-11-29	Hiv protease inhibitors useful for the treatment of aids
ZA896430B (en)	1990-05-30	Hiv protease inhibitors useful for the treatment of aids
IE880108L (en)	1988-07-16	Peptidase inhibitors

Legal Events

Date	Code	Title	Description
1990-09-01	PUAI	Public reference made under article 153(3) epc to a published international application that has entered the european phase	Free format text: ORIGINAL CODE: 0009012
1990-10-17	AK	Designated contracting states	Kind code of ref document: A1 Designated state(s): AT BE CH DE FR GB IT LI LU NL SE
1991-01-23	17P	Request for examination filed	Effective date: 19900530
1991-03-13	A4	Supplementary search report drawn up and despatched	Effective date: 19910123
1991-03-13	AK	Designated contracting states	Kind code of ref document: A4 Designated state(s): AT BE CH DE FR GB IT LI LU NL SE
1991-04-09	STAA	Information on the status of an ep patent application or granted ep patent	Free format text: STATUS: THE APPLICATION HAS BEEN WITHDRAWN
1991-05-15	18W	Application withdrawn	Withdrawal date: 19910321
1991-05-29	R18W	Application withdrawn (corrected)	Effective date: 19910321