[go: up one dir, main page]
More Web Proxy on the site http://driver.im/

EA201000180A1 - Способ получения производных пиримидина - Google Patents

Способ получения производных пиримидина

Info

Publication number
EA201000180A1
EA201000180A1 EA201000180A EA201000180A EA201000180A1 EA 201000180 A1 EA201000180 A1 EA 201000180A1 EA 201000180 A EA201000180 A EA 201000180A EA 201000180 A EA201000180 A EA 201000180A EA 201000180 A1 EA201000180 A1 EA 201000180A1
Authority
EA
Eurasian Patent Office
Prior art keywords
pyrimidine derivatives
group
nmesome
preparation
producing pyrimidine
Prior art date
Application number
EA201000180A
Other languages
English (en)
Inventor
Армин Бёрнер
Герд Кёниг
Наталия Андрушко
Васил Андрушко
Original Assignee
Рациофарм Гмбх
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Рациофарм Гмбх filed Critical Рациофарм Гмбх
Publication of EA201000180A1 publication Critical patent/EA201000180A1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/42—One nitrogen atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Настоящее изобретение относится к способу получения производных пиримидина формулы V, прежде всего в качестве промежуточных соединений для получения производных пиримидина, относящихся к классу соединений, эффективно подавляющих биосинтез холестерина в организме человека, таких, например, как ингибитор ГМГ-КоА-редуктазы, розувастатингде Z обозначает группу -NMeSOMe или группу, которую можно превратить в группу -NMeSOMe.
EA201000180A 2007-08-20 2008-08-19 Способ получения производных пиримидина EA201000180A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP07016279 2007-08-20
PCT/EP2008/006806 WO2009024323A2 (en) 2007-08-20 2008-08-19 Process for preparing pyrimidine derivatives

Publications (1)

Publication Number Publication Date
EA201000180A1 true EA201000180A1 (ru) 2010-10-29

Family

ID=40263577

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201000180A EA201000180A1 (ru) 2007-08-20 2008-08-19 Способ получения производных пиримидина

Country Status (5)

Country Link
US (1) US20110295005A1 (ru)
EP (1) EP2178847A2 (ru)
CA (1) CA2696195A1 (ru)
EA (1) EA201000180A1 (ru)
WO (1) WO2009024323A2 (ru)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9850213B2 (en) * 2013-11-25 2017-12-26 Jiangxi Boya Seehot Pharmaceutical Co., Ltd. Method for preparing rosuvastatin sodium
CN105622521B (zh) * 2014-12-01 2018-01-16 重庆安格龙翔医药科技有限公司 一种瑞舒伐他汀钙关键中间体的制备方法
CN105622522B (zh) * 2014-12-01 2018-01-16 重庆安格龙翔医药科技有限公司 一种瑞舒伐他汀钙关键中间体的合成方法
CN105712939B (zh) * 2014-12-01 2018-01-23 重庆安格龙翔医药科技有限公司 一种合成瑞舒伐他汀钙关键中间体的方法
GB2598768B (en) 2020-09-11 2024-09-11 Moa Tech Limited Herbicidal heterocyclic derivatives

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3960932A (en) * 1974-10-10 1976-06-01 The University Of Delaware Process for the preparation of aldehydes from organic halides
EP1691803A1 (en) * 2003-12-05 2006-08-23 Warner-Lambert Company LLC N-alkyl pyrroles as hmg-coa reductase inhibitors
WO2006017357A1 (en) * 2004-07-13 2006-02-16 Teva Pharmaceutical Industries Ltd. A process for the preparation of rosuvastatin involving a tempo-mediated oxidation step
GB0428328D0 (en) * 2004-12-24 2005-02-02 Astrazeneca Uk Ltd Chemical process
EP1893585A1 (en) * 2005-06-01 2008-03-05 Fermion Oy Process for the preparation of n-[4-(4-fluorophenyl)-5-formyl-6-isopropyl-pyrimidin-2-yl]-n-methylmethanesulfonamide
GB0514078D0 (en) * 2005-07-08 2005-08-17 Astrazeneca Uk Ltd Chemical process

Also Published As

Publication number Publication date
EP2178847A2 (en) 2010-04-28
WO2009024323A3 (en) 2009-08-06
US20110295005A1 (en) 2011-12-01
WO2009024323A2 (en) 2009-02-26
CA2696195A1 (en) 2009-02-26

Similar Documents

Publication Publication Date Title
MY150596A (en) Hsp90 inhibitors
MX2009003834A (es) Derivados de pirrolidina como inhibidores de iap.
JO2761B1 (en) Derivatives of alcohols 1-phenyl-2-pyridinealkyl as inhibitors
SG171593A1 (en) Inhibitors of c-fms kinase
WO2010008847A3 (en) Pi3k/m tor inhibitors
ATE542813T1 (de) 6-substituierte 2- heterocyclylaminopyrazinverbindungen als chk-1- inhibitoren
AU2012204982A8 (en) 2,4-diamino-6,7-dihydro-5H-pyrrolo[2,3]pyrimidine derivatives as FAK/Pyk2 inhibitors
MY150542A (en) Cmet inhibitors
UA102251C2 (ru) Производные аминодигидротиазина как ингибиторы васе для лечения болезни альцгеймера
EA200970519A1 (ru) Полиморфы сукцината 2-[6-(3-аминопиперидин-1-ил)-3-метил-2,4-диоксо-3,4-дигидро-2h-пиримидин-1-илметил]-4-фторбензонитрил и способы их применения
WO2008130638A3 (en) A process for preparing intermediates of hmg-coa reductase inhibitors
MX2012002752A (es) Compuestos de heteroarilo como inhibidores de cinasa.
TW200640912A (en) Novel processes for the preparation of a 2H-chromene
GB0904100D0 (en) Use of rosuvastatin lactols as medicaments
WO2008053334A3 (en) An improved process for preparing rosuvastatin calcium
WO2013080219A3 (en) Process for producing chiral statin side chain intermediates employing candida|antarctica lipase b
MY150280A (en) Process of preparing derivatives of 1-(2-halobiphenyl-4-yl)-cyclopropanecarboxylic acid
WO2009157858A8 (en) Use of cyclolignans for the treatment of a hyperactive immune system
MX2010010597A (es) Procesos para la preparacion de derivados de dioxina benzofusionados.
UA103329C2 (ru) Соли соединений-ингибиторов вич
EA201000180A1 (ru) Способ получения производных пиримидина
TNSN06260A1 (en) Process for the preparation of tryptase inhibitors
WO2010004578A3 (en) Novel and improved processes for the preparation of paliperidone
UA106988C2 (ru) Способ получения 1-бензил-3-гидроксиметил-1h-индазола и его производных и необходимые промежуточные соединения магния
WO2009121710A3 (en) Process for preparing nebivolol