DE60302571D1 - Verfahren zur herstellung der amorphen form von atorvastatin calzium salz - Google Patents

Verfahren zur herstellung der amorphen form von atorvastatin calzium salz

Info

Publication number: DE60302571D1
Authority: DE; Germany
Prior art keywords: calcium salt; atorvastatin calcium; preparing; amorph; water
Prior art date: 2002-04-29
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Fee Related

Application number

DE60302571T

Other languages

English (en)

Other versions

DE60302571T2 (de

Inventor

Stefano Turchetta

Pietro Massardo

Angela Tuozzi

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Chemi SpA

Original Assignee

Chemi SpA

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-04-29

Filing date

2003-04-25

Publication date

2006-01-05

2003-04-25 Application filed by Chemi SpA filed Critical Chemi SpA

2006-01-05 Application granted granted Critical

2006-01-05 Publication of DE60302571D1 publication Critical patent/DE60302571D1/de

2006-08-03 Publication of DE60302571T2 publication Critical patent/DE60302571T2/de

2023-04-26 Anticipated expiration legal-status Critical

Status Expired - Fee Related legal-status Critical Current

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Pyrrole Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicinal Preparation (AREA)

DE60302571T 2002-04-29 2003-04-25 Verfahren zur herstellung der amorphen form von atorvastatin calzium salz Expired - Fee Related DE60302571T2 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
IT2002MI000907A ITMI20020907A1 (it)	2002-04-29	2002-04-29	Processo di preparazione della forma amorfa del sale di calcio della atorvastatina
ITMI20020907		2002-04-29
PCT/EP2003/004313 WO2003093233A1 (en)	2002-04-29	2003-04-25	Process for the preparation of the amorphous form of atorvastatin calcium salt

Publications (2)

Publication Number	Publication Date
DE60302571D1 true DE60302571D1 (de)	2006-01-05
DE60302571T2 DE60302571T2 (de)	2006-08-03

Family

ID=11449799

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DE60302571T Expired - Fee Related DE60302571T2 (de)	2002-04-29	2003-04-25	Verfahren zur herstellung der amorphen form von atorvastatin calzium salz

Country Status (9)

Country	Link
US (1)	US20060128971A1 (de)
EP (1)	EP1509500B1 (de)
AT (1)	ATE311365T1 (de)
AU (1)	AU2003233064A1 (de)
CA (1)	CA2483862A1 (de)
DE (1)	DE60302571T2 (de)
ES (1)	ES2253674T3 (de)
IT (1)	ITMI20020907A1 (de)
WO (1)	WO2003093233A1 (de)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US8367848B2 (en)	2003-04-11	2013-02-05	Lek Pharmaceuticals D.D.	Process for the preparation of amorphous calcium salt of atorvastatin
HUE029911T2 (en) *	2004-07-16	2017-04-28	Lek Pharmaceuticals	Products of atorvastatin calcium oxidative degradation
WO2006011155A1 (en) *	2004-07-26	2006-02-02	Apollo International Limited	One pot process for amorphous atorvastain calcium
ES2263370B1 (es) *	2005-02-16	2007-12-01	Ercros Industrial, S.A.	Atorvastatina calcica amorfa estabilizada y procedimiento para su obtencion.
US20100113802A1 (en) *	2006-11-02	2010-05-06	Cadila Pharmaceuticals Limited	Process for preparing amorphous atorvastatin hemi calcium salt and its itermediate
KR100833439B1 (ko) *	2007-01-02	2008-05-29	씨제이제일제당 (주)	비결정형 아토르바스타틴 칼슘의 개선된 제조방법
EP2075246A1 (de)	2007-12-27	2009-07-01	M. J. Institute of Research	Verfahren zur Herstellung einer amorphen Form von Atorvastatin-Hemicalcium-Salz
US9334266B2 (en)	2009-09-04	2016-05-10	The University Of Toledo	Catalysts and related processes for producing optically pure beta-lactones from aldehydes and compositions produced thereby

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4681893A (en) *	1986-05-30	1987-07-21	Warner-Lambert Company	Trans-6-[2-(3- or 4-carboxamido-substituted pyrrol-1-yl)alkyl]-4-hydroxypyran-2-one inhibitors of cholesterol synthesis
FI94339C (fi) *	1989-07-21	1995-08-25	Warner Lambert Co	Menetelmä farmaseuttisesti käyttökelpoisen /R-(R,R)/-2-(4-fluorifenyyli)- , -dihydroksi-5-(1-metyylietyyli)-3-fenyyli-4-/(fenyyliamino)karbonyyli/-1H-pyrroli-1-heptaanihapon ja sen farmaseuttisesti hyväksyttävien suolojen valmistamiseksi
HRP960312B1 (en) *	1995-07-17	2001-10-31	Warner Lambert Co	NOVEL PROCESS FOR THE PRODUCTION OF AMORPHOUS /R-(R, R)/-2-(4-FLUOROPHENYL)-"beta", "delta"-DIHYDROXY-5-PHENYL-4-/(PHENYLAMINO)CARBONYL/-1H-PYRROLE -1-HEPTANOIC ACID CALCIUM SALT (2 : 1)
HRP960313B1 (en) *	1995-07-17	2002-08-31	Warner Lambert Co	Form iii crystalline (r- (r, r)-2- (4-fluorophenyl) -beta-delta-hydroxy-5-(1-methylethyl) -3-phenyl-4- ((phenylamino) carbonyl -1h-pyrrole-1-heptanoic acid calcium salt (2:1)
IL128862A (en) *	1995-07-17	2007-12-03	Warner Lambert Co	[R - (R * R *)] - 2 - (4 - fluorophenyl) - ß, d - dihydroxy - 5 - (1 - methyl - ethyl) 3 - phenyl - 4 - [(phenamino) carbonyl)] - 1H - Pyrol - 1 - Patenoic acid Hydrogen salt Hydrogen crystalline (Atorostatin) Crystalline hydrate
US6087511A (en) *	1996-07-16	2000-07-11	Warner-Lambert Company	Process for the production of amorphous [R-(R,R)]-2-(4-fluorophenyl)-β,δ-dihydroxy-5-(1-methylethyl )-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrole-1-heptanoic acid) calcium salt (2:1)
IN191236B (de) *	1999-05-25	2003-10-11	Ranbaxy Lab Ltd
HU226640B1 (en) *	1999-10-18	2009-05-28	Egis Gyogyszergyar Nyilvanosan	Process for producing amorphous atorvastatin calcium salt
SI20425A (sl) *	1999-12-10	2001-06-30	LEK tovarna farmacevtskih in kemi�nih izdelkov d.d.	Priprava amorfnega atorvastatina
SI20814A (sl) *	2001-01-23	2002-08-31	LEK, tovarna farmacevtskih in kemi�nih izdelkov, d.d.	Priprava amorfnega atorvastatina
WO2003018547A2 (en) *	2001-08-31	2003-03-06	Morepen Laboratories Ltd.	An improved process for the preparation of amorphous atorvastatin calcium salt (2:1)

2002
- 2002-04-29 IT IT2002MI000907A patent/ITMI20020907A1/it unknown
2003
- 2003-04-25 DE DE60302571T patent/DE60302571T2/de not_active Expired - Fee Related
- 2003-04-25 ES ES03727362T patent/ES2253674T3/es not_active Expired - Lifetime
- 2003-04-25 EP EP03727362A patent/EP1509500B1/de not_active Expired - Lifetime
- 2003-04-25 US US10/512,895 patent/US20060128971A1/en not_active Abandoned
- 2003-04-25 AU AU2003233064A patent/AU2003233064A1/en not_active Abandoned
- 2003-04-25 WO PCT/EP2003/004313 patent/WO2003093233A1/en not_active Application Discontinuation
- 2003-04-25 AT AT03727362T patent/ATE311365T1/de not_active IP Right Cessation
- 2003-04-25 CA CA002483862A patent/CA2483862A1/en not_active Abandoned

Also Published As

Publication number	Publication date
DE60302571T2 (de)	2006-08-03
ES2253674T3 (es)	2006-06-01
WO2003093233A1 (en)	2003-11-13
CA2483862A1 (en)	2003-11-13
EP1509500A1 (de)	2005-03-02
US20060128971A1 (en)	2006-06-15
ATE311365T1 (de)	2005-12-15
AU2003233064A1 (en)	2003-11-17
ITMI20020907A0 (it)	2002-04-29
ITMI20020907A1 (it)	2003-10-29
EP1509500B1 (de)	2005-11-30

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Legal Events

Date	Code	Title	Description
2006-12-21	8364	No opposition during term of opposition
2008-02-14	8339	Ceased/non-payment of the annual fee