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CY1109750T1 - ΔΙΑΛΥΤΗ ΓΛΥΚΟΠΡΩΤΕΪΝΗ ΥΑΛΟΥΡΟΝΙΔΑΣΗΣ (sHASEGP), ΔΙΑΔΙΚΑΣΙΑ ΓΙΑ ΤΗΝ ΠΑΡΑΣΚΕΥΗ ΤΗΣ, ΧΡΗΣΕΙΣ ΚΑΙ ΦΑΡΜΑΚΕΥΤΙΚΕΣ ΣΥΝΘΕΣΕΙΣ ΠΟΥ ΤΗΝ ΠΕΡΙΛΑΜΒΑΝΟΥΝ - Google Patents

ΔΙΑΛΥΤΗ ΓΛΥΚΟΠΡΩΤΕΪΝΗ ΥΑΛΟΥΡΟΝΙΔΑΣΗΣ (sHASEGP), ΔΙΑΔΙΚΑΣΙΑ ΓΙΑ ΤΗΝ ΠΑΡΑΣΚΕΥΗ ΤΗΣ, ΧΡΗΣΕΙΣ ΚΑΙ ΦΑΡΜΑΚΕΥΤΙΚΕΣ ΣΥΝΘΕΣΕΙΣ ΠΟΥ ΤΗΝ ΠΕΡΙΛΑΜΒΑΝΟΥΝ

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Publication number
CY1109750T1
CY1109750T1 CY20101100068T CY101100068T CY1109750T1 CY 1109750 T1 CY1109750 T1 CY 1109750T1 CY 20101100068 T CY20101100068 T CY 20101100068T CY 101100068 T CY101100068 T CY 101100068T CY 1109750 T1 CY1109750 T1 CY 1109750T1
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CY
Cyprus
Prior art keywords
shasegp
reactive
neutral
glypro
procedure
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Application number
CY20101100068T
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English (en)
Inventor
Louis H Bookbinder
Anirban Kundu
Gregory I Frost
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Halozyme, Inc.
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=32962713&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CY1109750(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Halozyme, Inc. filed Critical Halozyme, Inc.
Publication of CY1109750T1 publication Critical patent/CY1109750T1/el

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Abstract

Η εφεύρεση αναφέρεται στην ανακάλυψη καινοτόμων διαλυτών ουδέτερων δραστικών Γλυκοπρωτεϊνών Υαλουρονιδάσης (sHASEGP's), μεθόδους για την κατασκευή τους, και στην χρήση τους στην διευκόλυνση της χορήγησης άλλων μορίων ή στην ανακούφιση παθολογικών καταστάσεων που σχετίζονται με τις γλυκοσαμινογλυκάνες. Ελάχιστα δραστικά τμήματα πολυπεπτιδίων των διαλυτών, ουδέτερων δραστικών πεδίων των sHASEGP περιγράφονται, τα οποία περιλαμβάνουν τμήματα σακχάρων που είναι συνδεδεμένα σε ασπαραγινικό που απαιτούνται για ένα λειτουργικό ουδέτερο δραστικό πεδίο υαλουρονιδάσης. Περιλαμβάνονται τροποποιημένες αμινοτελικά καθοδηγητικά πεπτίδια τα οποία ενισχύουν την έκκριση των sHASEGP. Η εφεύρεση περιλαμβάνει επιπλέον σιαλιλυλοποιημένες και πεγκυλιωμένες μορφές μιας ανασυνδυασμένης sHASEGP προκειμένου να ενισχυθεί η σταθερότητα και η φαρμακοκινητική στον ορό στα φυσικώς υπάρχοντα ένζυμα σφαγείου. Περιγράφονται επιπλέον κατάλληλες συνθέσεις μιας ουσιαστικά καθαρής ανασυνδυασμένης sHASEGP γλυκοπρωτεΐνης που προέρχεται από ένα ευκαρυωτικό κύτταρο που παράγει την κατάλληλη γλυκοσυλίωση που απαιτείται για την βέλτιστη απόδοση της.
CY20101100068T 2003-03-05 2010-01-22 ΔΙΑΛΥΤΗ ΓΛΥΚΟΠΡΩΤΕΪΝΗ ΥΑΛΟΥΡΟΝΙΔΑΣΗΣ (sHASEGP), ΔΙΑΔΙΚΑΣΙΑ ΓΙΑ ΤΗΝ ΠΑΡΑΣΚΕΥΗ ΤΗΣ, ΧΡΗΣΕΙΣ ΚΑΙ ΦΑΡΜΑΚΕΥΤΙΚΕΣ ΣΥΝΘΕΣΕΙΣ ΠΟΥ ΤΗΝ ΠΕΡΙΛΑΜΒΑΝΟΥΝ CY1109750T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US45236003P 2003-03-05 2003-03-05
EP04717941A EP1603541B2 (en) 2003-03-05 2004-03-05 SOLUBLE HYALURONIDASE GLYCOPROTEIN (sHASEGP), PROCESS FOR PREPARING THE SAME, USES AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEREOF

Publications (1)

Publication Number Publication Date
CY1109750T1 true CY1109750T1 (el) 2014-09-10

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ID=32962713

Family Applications (6)

Application Number Title Priority Date Filing Date
CY20101100068T CY1109750T1 (el) 2003-03-05 2010-01-22 ΔΙΑΛΥΤΗ ΓΛΥΚΟΠΡΩΤΕΪΝΗ ΥΑΛΟΥΡΟΝΙΔΑΣΗΣ (sHASEGP), ΔΙΑΔΙΚΑΣΙΑ ΓΙΑ ΤΗΝ ΠΑΡΑΣΚΕΥΗ ΤΗΣ, ΧΡΗΣΕΙΣ ΚΑΙ ΦΑΡΜΑΚΕΥΤΙΚΕΣ ΣΥΝΘΕΣΕΙΣ ΠΟΥ ΤΗΝ ΠΕΡΙΛΑΜΒΑΝΟΥΝ
CY20151100105T CY1116110T1 (el) 2003-03-05 2015-02-02 ΔΙΑΛΥΤΗ ΓΛΥΚΟΠΡΩΤΕΪΝΗ ΥΑΛΟΥΡΟΝΙΔΑΣΗΣ (sHASEGP), ΔΙΑΔΙΚΑΣΙΑ ΓΙΑ ΤΗΝ ΠΑΡΑΣΚΕΥΗ ΤΗΣ, ΧΡΗΣΕΙΣ ΚΑΙ ΦΑΡΜΑΚΕΥΤΙΚΕΣ ΣΥΝΘΕΣΕΙΣ ΠΟΥ ΤΗΝ ΠΕΡΙΛΑΜΒΑΝΟΥΝ
CY20151100333T CY1116370T1 (el) 2003-03-05 2015-04-07 ΔΙΑΛΥΤΗ ΓΛΥΚΟΠΡΩΤΕΪΝΗ ΥΑΛΟΥΡΟΝΙΔΑΣΗΣ (sHASEGP), ΔΙΑΔΙΚΑΣΙΑ ΓΙΑ ΤΗΝ ΠΑΡΑΣΚΕΥΗ ΤΗΣ, ΧΡΗΣΕΙΣ ΚΑΙ ΦΑΡΜΑΚΕΥΤΙΚΕΣ ΣΥΝΘΕΣΕΙΣ ΠΟΥ ΤΗΝ ΠΕΡΙΛΑΜΒΑΝΟΥΝ
CY2015033C CY2015033I1 (el) 2003-03-05 2015-07-21 ΔΙΑΛΥΤΗ ΓΛΥΚΟΠΡΩΤΕΪΝΗ ΥΑΛΟΥΡΟΝΙΔΑΣΗΣ (sHASEGP), ΔΙΑΔΙΚΑΣΙΑ ΓΙΑ ΤΗΝ ΠΑΡΑΣΚΕΥΗ ΤΗΣ, ΧΡΗΣΕΙΣ ΚΑΙ ΦΑΡΜΑΚΕΥΤΙΚΕΣ ΣΥΝΘΕΣΕΙΣ ΠΟΥ ΤΗΝ ΠΕΡΙΛΑΜΒΑΝΟΥΝ
CY20161100267T CY1117358T1 (el) 2003-03-05 2016-03-31 ΔΙΑΛΥΤΗ ΓΛΥΚΟΠΡΩΤΕΪΝΗ ΥΑΛΟΥΡΟΝΙΔΑΣΗΣ (sHASEGP), ΔΙΑΔΙΚΑΣΙΑ ΓΙΑ ΤΗΝ ΠΑΡΑΣΚΕΥΗ ΤΗΣ, ΧΡΗΣΕΙΣ ΚΑΙ ΦΑΡΜΑΚΕΥΤΙΚΕΣ ΣΥΝΘΕΣΕΙΣ ΠΟΥ ΤΗΝ ΠΕΡΙΛΑΜΒΑΝΟΥΝ
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KR20130135986A (ko) 2013-12-11
JP5538770B2 (ja) 2014-07-02
BRPI0408116B1 (pt) 2022-09-20
LU92780I9 (el) 2024-05-13
AU2004218354A1 (en) 2004-09-16
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US20130058893A1 (en) 2013-03-07
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US20040268425A1 (en) 2004-12-30
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US20190224286A1 (en) 2019-07-25
AU2009245838A1 (en) 2010-01-07
US20110152359A1 (en) 2011-06-23
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IL227867A (en) 2015-09-24
PT2177620E (pt) 2015-02-16
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US8431380B2 (en) 2013-04-30
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US8431124B2 (en) 2013-04-30
EP1603541A4 (en) 2006-11-22
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US9562223B2 (en) 2017-02-07
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US20230321203A1 (en) 2023-10-12
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