[go: up one dir, main page]
More Web Proxy on the site http://driver.im/

CR8248A - Forma cristalina beta del clorhidrato de ivabradina, su procedimiento de preparacion y composiciones farmaceuticas que la contienen - Google Patents

Forma cristalina beta del clorhidrato de ivabradina, su procedimiento de preparacion y composiciones farmaceuticas que la contienen

Info

Publication number
CR8248A
CR8248A CR8248A CR8248A CR8248A CR 8248 A CR8248 A CR 8248A CR 8248 A CR8248 A CR 8248A CR 8248 A CR8248 A CR 8248A CR 8248 A CR8248 A CR 8248A
Authority
CR
Costa Rica
Prior art keywords
expressed
beta
pharmaceutical compositions
compositions containing
preparation procedure
Prior art date
Application number
CR8248A
Other languages
English (en)
Inventor
Horvath Stepahne
Noelle Auguste Marie
Damien Gerard
Original Assignee
Servier Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34954954&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CR8248(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Servier Lab filed Critical Servier Lab
Publication of CR8248A publication Critical patent/CR8248A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/16—Benzazepines; Hydrogenated benzazepines
    • D—TEXTILES; PAPER
    • D21—PAPER-MAKING; PRODUCTION OF CELLULOSE
    • D21H—PULP COMPOSITIONS; PREPARATION THEREOF NOT COVERED BY SUBCLASSES D21C OR D21D; IMPREGNATING OR COATING OF PAPER; TREATMENT OF FINISHED PAPER NOT COVERED BY CLASS B31 OR SUBCLASS D21G; PAPER NOT OTHERWISE PROVIDED FOR
    • D21H27/00—Special paper not otherwise provided for, e.g. made by multi-step processes
    • D21H27/10—Packing paper
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D81/00—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents
    • B65D81/18—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents providing specific environment for contents, e.g. temperature above or below ambient
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D85/00—Containers, packaging elements or packages, specially adapted for particular articles or materials
    • B65D85/30—Containers, packaging elements or packages, specially adapted for particular articles or materials for articles particularly sensitive to damage by shock or pressure
    • D—TEXTILES; PAPER
    • D21—PAPER-MAKING; PRODUCTION OF CELLULOSE
    • D21H—PULP COMPOSITIONS; PREPARATION THEREOF NOT COVERED BY SUBCLASSES D21C OR D21D; IMPREGNATING OR COATING OF PAPER; TREATMENT OF FINISHED PAPER NOT COVERED BY CLASS B31 OR SUBCLASS D21G; PAPER NOT OTHERWISE PROVIDED FOR
    • D21H21/00—Non-fibrous material added to the pulp, characterised by its function, form or properties; Paper-impregnating or coating material, characterised by its function, form or properties
    • D21H21/14—Non-fibrous material added to the pulp, characterised by its function, form or properties; Paper-impregnating or coating material, characterised by its function, form or properties characterised by function or properties in or on the paper
    • D21H21/16—Sizing or water-repelling agents
    • D—TEXTILES; PAPER
    • D21—PAPER-MAKING; PRODUCTION OF CELLULOSE
    • D21H—PULP COMPOSITIONS; PREPARATION THEREOF NOT COVERED BY SUBCLASSES D21C OR D21D; IMPREGNATING OR COATING OF PAPER; TREATMENT OF FINISHED PAPER NOT COVERED BY CLASS B31 OR SUBCLASS D21G; PAPER NOT OTHERWISE PROVIDED FOR
    • D21H27/00—Special paper not otherwise provided for, e.g. made by multi-step processes
    • D21H27/30—Multi-ply
    • D21H27/40—Multi-ply at least one of the sheets being non-planar, e.g. crêped

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Mechanical Engineering (AREA)
  • Hospice & Palliative Care (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Analysing Materials By The Use Of Radiation (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Forma crsitalina Bd del clorihidrato de ivabradina segun la formula (I) de la presente solicitud, caracterizada por el digrama de difraccion X sobre polvo siguiente, medido en un difractometro PANalytical X'Per Pro con un detector X'Celerator, y expresado en terminos de posicion de linea (angulo de Bragg 2 theta, expresado en grados); altura de linea (expresado en cuentas), superficie de linea (expresado en cuentas x grados); anchura a media altura de las lineas ("FWHM, expresada en grados) y distancia interreticular d (expresadqa en A).
CR8248A 2005-02-28 2006-02-21 Forma cristalina beta del clorhidrato de ivabradina, su procedimiento de preparacion y composiciones farmaceuticas que la contienen CR8248A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0501985A FR2882553B1 (fr) 2005-02-28 2005-02-28 Forme cristalline beta du chlorhydrate de l'ivabradine, son procede de preparation, et les compositions pharmaceutiques qui la contiennent

Publications (1)

Publication Number Publication Date
CR8248A true CR8248A (es) 2008-10-06

Family

ID=34954954

Family Applications (1)

Application Number Title Priority Date Filing Date
CR8248A CR8248A (es) 2005-02-28 2006-02-21 Forma cristalina beta del clorhidrato de ivabradina, su procedimiento de preparacion y composiciones farmaceuticas que la contienen

Country Status (43)

Country Link
US (3) US7361649B2 (es)
EP (1) EP1695965B9 (es)
JP (1) JP4625776B2 (es)
KR (1) KR100827502B1 (es)
CN (1) CN1827600B (es)
AP (1) AP1907A (es)
AR (1) AR053147A1 (es)
AT (1) ATE407926T1 (es)
BR (1) BRPI0600623A (es)
CA (1) CA2537414C (es)
CO (1) CO5770096A1 (es)
CR (1) CR8248A (es)
CU (1) CU23614B7 (es)
CY (1) CY1109072T1 (es)
DE (1) DE602006002624D1 (es)
DK (1) DK1695965T3 (es)
EA (1) EA008464B1 (es)
EC (2) ECSP066373A (es)
ES (1) ES2313581T3 (es)
FR (1) FR2882553B1 (es)
GE (1) GEP20084465B (es)
GT (1) GT200600084A (es)
HK (1) HK1096387A1 (es)
HR (1) HRP20080520T3 (es)
IL (1) IL173957A0 (es)
JO (1) JO2548B1 (es)
MA (1) MA28131A1 (es)
ME (1) ME01408B (es)
MY (1) MY158128A (es)
NO (1) NO338370B1 (es)
NZ (1) NZ545576A (es)
PE (1) PE20061009A1 (es)
PL (1) PL1695965T3 (es)
PT (1) PT1695965E (es)
RS (1) RS50661B (es)
SA (1) SA06270038B1 (es)
SG (1) SG125228A1 (es)
SI (1) SI1695965T1 (es)
TW (1) TWI314144B (es)
UA (1) UA80904C2 (es)
UY (1) UY29405A1 (es)
WO (1) WO2006092493A1 (es)
ZA (1) ZA200601762B (es)

Families Citing this family (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2868777B1 (fr) * 2004-04-13 2006-05-26 Servier Lab Nouveau procede de synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable
FR2882556B1 (fr) * 2005-02-28 2007-05-04 Servier Lab Forme cristalline gamma d du chlorhydrate de l'ivabradine, son procede de preparation, et les compositions pharmaceutiques qui la contiennent
FR2882554B1 (fr) * 2005-02-28 2007-05-04 Servier Lab Forme critalline beta d du chlorhydrate de l'ivabradine, son procede de preparation, et les compositions pharmaceutiques qui la contiennent
FR2882555B1 (fr) * 2005-02-28 2007-05-04 Servier Lab Forme cristalline gamma du chlorhydrate de l'ivabradine, son procede de preparation, et les compositions pharmaceutiques qui la contiennent
FR2882553B1 (fr) * 2005-02-28 2007-05-04 Servier Lab Forme cristalline beta du chlorhydrate de l'ivabradine, son procede de preparation, et les compositions pharmaceutiques qui la contiennent
FR2891827B1 (fr) * 2005-10-11 2007-12-28 Servier Lab Forme cristalline deltad du chlorhydrate de l'ivabradine, son procede de preparation, et les compositions pharmaceutiques qui la contiennent
FR2891826B1 (fr) * 2005-10-11 2007-12-28 Servier Lab Forme cristalline 6 du chlorhydrate de l'ivabradine, son procede de preparation et les compositions pharmaceutiques qui la contiennent
FR2894825B1 (fr) * 2005-12-21 2010-12-03 Servier Lab Nouvelle association d'un inhibiteur du courant if sinusal et d'un inhibiteur de l'enzyme de conversion et les compositions pharmaceutiques qui la contiennent
ES2381771T3 (es) 2006-11-30 2012-05-31 Cadila Healthcare Limited Procedimiento para la preparación de hidrocloruro de ivabradina
FR2911279B1 (fr) * 2007-01-11 2009-03-06 Servier Lab Utilisation de l'ivabradine pour l'obtention de medicaments destines au traitement de la dysfonction endotheliale
CN101353325B (zh) * 2007-07-27 2011-11-09 上海优拓医药科技有限公司 稳定型盐酸伊伐布雷定结晶及其制备方法
KR101478855B1 (ko) 2007-05-30 2015-01-02 인드-스위프트 래버러토리즈 리미티드 이바브라딘 히드로클로라이드 및 그의 다형태의 제조방법
FR2938194B1 (fr) * 2008-11-07 2012-08-31 Servier Lab Utilisation de l'ivabradine comme agent de diagnostic dans la methode d'angiographie coronaire par tomodensitometrie multicoupe
ES2402765T3 (es) 2008-12-22 2013-05-08 Krka, D.D., Novo Mesto Procedimiento de preparación de ivabradina
CN101774969B (zh) 2009-01-13 2012-07-04 江苏恒瑞医药股份有限公司 硫酸伊伐布雷定及其i型结晶的制备方法
EP2534135A2 (en) 2010-02-12 2012-12-19 KRKA, D.D., Novo Mesto Novel forms of ivabradine hydrochloride
HUP1000245A2 (en) 2010-05-07 2011-11-28 Richter Gedeon Nyrt Industrial process for the production ivabradin salts
TWI499587B (zh) * 2010-06-03 2015-09-11 Jiangsu Hengrui Medicine Co 硫酸伊伐佈雷定及其ｉ型結晶的製備方法
CA2800442C (en) 2010-06-14 2018-05-22 Ratiopharm Gmbh Ivabradine-containing pharmaceutical composition with modified release
WO2012025940A1 (en) 2010-08-25 2012-03-01 Cadila Healthcare Limited Polymorphic form of ivabradine hydrochloride and process for preparation thereof
CN102304088B (zh) * 2011-07-07 2013-06-19 石药集团欧意药业有限公司 一种伊伐布雷定化合物、制备方法及其药物组合物
US9440924B2 (en) 2011-08-02 2016-09-13 Sandoz Ag Acetone solvate of ivabradine hydrochloride
EP2589594A1 (en) 2011-11-04 2013-05-08 Urquima S.A. Ivabradine hydrochloride Form IV
WO2013064427A1 (en) 2011-11-04 2013-05-10 Synthon Bv A process for making crystalline delta-form of ivabradine hydrochloride
WO2013102919A1 (en) 2011-11-14 2013-07-11 Cadila Healthcare Limited Polymorphic forms of ivabradine hydrochloride
WO2014080259A1 (en) * 2012-11-21 2014-05-30 Enaltec Labs Pvt. Ltd. Novel polymorphic forms of alcaftadine
WO2014114341A1 (en) 2013-01-24 2014-07-31 Synthon Bv Process for making ivabradine
EP2781509B2 (en) 2013-03-19 2023-06-14 Chemo Research, S.L. New polymorph of ivabradine hydrochloride and method for its preparation
CZ305096B6 (cs) 2013-10-02 2015-04-29 Zentiva, K.S. Pevná forma Ivabradin hydrochloridu a (S)-mandlové kyseliny a její farmaceutická kompozice
WO2015001133A1 (en) 2013-12-12 2015-01-08 Synthon B.V. Pharmaceutical composition comprising amorphous ivabradine
EP2774606B1 (en) 2014-02-14 2019-01-30 Synthon B.V. Pharmaceutical composition comprising ivabradine hydrochloride polymorph IV
CZ305436B6 (cs) 2014-07-10 2015-09-16 Zentiva, K.S. Pevná forma Ivabradin hydrochloridu a (R)-mandlové kyseliny a její farmaceutická kompozice
WO2016102423A1 (en) 2014-12-22 2016-06-30 Ratiopharm Gmbh Composition comprising ivabradine in a dissolved form
GR1008821B (el) 2015-06-11 2016-08-01 Φαρματεν Ανωνυμος Βιομηχανικη Και Εμπορικη Εταιρεια Φαρμακευτικων Ιατρικων Και Καλλυντικων Προϊοντων Φαρμακευτικο σκευασμα που περιλαμβανει υδροχλωρικη ιβαμπραδινη και μεθοδος παρασκευης αυτου
CN107056706B (zh) * 2015-12-21 2020-05-05 江苏恒瑞医药股份有限公司 一种用于制备盐酸伊伐布雷定α晶型的方法
US11273162B2 (en) * 2016-04-01 2022-03-15 Mississippi State University Compositions and methods targeting HCN channels for breathing therapeutics
EP3366282A1 (en) 2017-02-28 2018-08-29 Sanovel Ilac Sanayi ve Ticaret A.S. Solid oral pharmaceutical compositions of ivabradine
TR201703066A2 (tr) 2017-02-28 2018-09-21 Sanovel Ilac Sanayi Ve Ticaret Anonim Sirketi İvabradi̇ni̇n kati oral farmasöti̇k kompozi̇syonlari
US20230181472A1 (en) 2018-10-30 2023-06-15 Amgen Inc. Process of making ivabradine hydrochloride drug product
JP2023507626A (ja) 2019-12-16 2023-02-24 テナックス・セラピューティクス，インコーポレイテッド 駆出率が保たれた心不全を伴う肺高血圧症（ＰＨ－ＨＦ－ｐＥＦ）を治療するためのレボシメンダン
IT202000025312A1 (it) 2020-10-26 2022-04-26 Cambrex Profarmaco Milano S R L Processi per la preparazione di polimorfi di ivabradina hcl

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3119874A1 (de) * 1981-05-19 1982-12-09 Dr. Karl Thomae Gmbh, 7950 Biberach "benzazepinderivate, ihre herstellung und ihre verwendung als arzneimittel"
US4490369A (en) * 1981-05-19 1984-12-25 Dr. Karl Thomae Gesellschaft Mit Beschrankter Haftung Benzazepine derivatives, their pharmaceutical compositions and method of use
AU647528B2 (en) 1990-08-29 1994-03-24 Humanetics Corporation Treatment process for promoting weight loss employing a substituted delta5-androstene
FR2681862B1 (fr) * 1991-09-27 1993-11-12 Adir Cie Nouvelles (benzocycloalkyl)alkylamines, leur procede de preparation, et les compositions pharmaceutiques qui les contiennent.
FR2818552B1 (fr) 2000-12-26 2003-02-07 Servier Lab Compositions pharmaceutique solide thermoformable pour la liberation controlee d'ivabradine
FR2834896B1 (fr) * 2002-01-23 2004-02-27 Servier Lab Composition pharmaceutique orodispersible d'ivabradine
FR2868777B1 (fr) * 2004-04-13 2006-05-26 Servier Lab Nouveau procede de synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable
FR2882555B1 (fr) * 2005-02-28 2007-05-04 Servier Lab Forme cristalline gamma du chlorhydrate de l'ivabradine, son procede de preparation, et les compositions pharmaceutiques qui la contiennent
FR2882556B1 (fr) * 2005-02-28 2007-05-04 Servier Lab Forme cristalline gamma d du chlorhydrate de l'ivabradine, son procede de preparation, et les compositions pharmaceutiques qui la contiennent
FR2882554B1 (fr) * 2005-02-28 2007-05-04 Servier Lab Forme critalline beta d du chlorhydrate de l'ivabradine, son procede de preparation, et les compositions pharmaceutiques qui la contiennent
FR2882553B1 (fr) * 2005-02-28 2007-05-04 Servier Lab Forme cristalline beta du chlorhydrate de l'ivabradine, son procede de preparation, et les compositions pharmaceutiques qui la contiennent
FR2891827B1 (fr) * 2005-10-11 2007-12-28 Servier Lab Forme cristalline deltad du chlorhydrate de l'ivabradine, son procede de preparation, et les compositions pharmaceutiques qui la contiennent
FR2891826B1 (fr) * 2005-10-11 2007-12-28 Servier Lab Forme cristalline 6 du chlorhydrate de l'ivabradine, son procede de preparation et les compositions pharmaceutiques qui la contiennent

Also Published As

Publication number Publication date
HRP20080520T3 (en) 2009-01-31
SI1695965T1 (sl) 2009-02-28
NO20060946L (no) 2006-08-29
SG125228A1 (en) 2006-09-29
US7361649B2 (en) 2008-04-22
TWI314144B (en) 2009-09-01
CY1109072T1 (el) 2014-07-02
ME01408B (me) 2010-06-30
EP1695965B9 (fr) 2009-03-04
FR2882553B1 (fr) 2007-05-04
US20100041640A1 (en) 2010-02-18
US7879842B2 (en) 2011-02-01
CA2537414A1 (fr) 2006-08-28
ATE407926T1 (de) 2008-09-15
US20080161285A1 (en) 2008-07-03
SA06270038B1 (ar) 2010-03-29
JP2006241154A (ja) 2006-09-14
CU20060039A7 (es) 2008-06-30
DE602006002624D1 (de) 2008-10-23
CN1827600B (zh) 2010-08-11
ECSP066375A (es) 2006-11-16
JP4625776B2 (ja) 2011-02-02
CU23614B7 (es) 2011-01-27
KR100827502B1 (ko) 2008-05-06
DK1695965T3 (da) 2008-12-15
EA200600322A1 (ru) 2006-08-25
PL1695965T3 (pl) 2009-01-30
MA28131A1 (fr) 2006-09-01
MY158128A (en) 2016-08-30
ECSP066373A (es) 2006-10-17
GEP20084465B (en) 2008-08-25
HK1096387A1 (en) 2007-06-01
ZA200601762B (en) 2007-04-25
AP2006003519A0 (en) 2006-02-28
NO338370B1 (no) 2016-08-15
CN1827600A (zh) 2006-09-06
EP1695965A1 (fr) 2006-08-30
RS50661B (sr) 2010-06-30
PT1695965E (pt) 2008-10-08
CO5770096A1 (es) 2007-06-29
AR053147A1 (es) 2007-04-25
JO2548B1 (en) 2010-09-05
UY29405A1 (es) 2006-07-31
NZ545576A (en) 2007-01-26
UA80904C2 (en) 2007-11-12
AU2006200856A1 (en) 2010-01-28
GT200600084A (es) 2006-11-22
FR2882553A1 (fr) 2006-09-01
BRPI0600623A (pt) 2006-10-24
PE20061009A1 (es) 2006-11-18
ES2313581T3 (es) 2009-03-01
AP1907A (en) 2008-10-23
EP1695965B1 (fr) 2008-09-10
TW200640873A (en) 2006-12-01
US20060194962A1 (en) 2006-08-31
IL173957A0 (en) 2006-07-05
KR20060095501A (ko) 2006-08-31
CA2537414C (fr) 2010-02-16
EA008464B1 (ru) 2007-06-29
WO2006092493A1 (fr) 2006-09-08

Similar Documents

Publication Publication Date Title
CR8248A (es) Forma cristalina beta del clorhidrato de ivabradina, su procedimiento de preparacion y composiciones farmaceuticas que la contienen
CR8247A (es) FORMA CRISTALINA BETA-d DEL CLORHIDRATO DE IVABRADINA, SU PROCEDIMIENTO DE PREPARACION Y COMPOSICIONES FARMACEUTICAS QUE LA CONTIENEN
AR056931A1 (es) Forma cristalina gamma d del clorhidrato de ivabradina, un procedimiento para su preparacion, composiciones farmaceuticas que la contienen, y usos en trastornos cardiovasculares
UY29856A1 (es) Forma cristalina 8d del clorhidrato de la ivabradina, su procedimiento de preparación, y las composiciones farmaceuticas que la contienen
AR056572A1 (es) FORMA CRISTALINA ð DEL CLOHIDRATO DE IVABRADINA,UN PROCEDIMIENTO PARA SU PREPARACION,COMPOSICIONES FARMACEUTICAS QUE LA CONTIENEN Y USOS EN TRASTORNOS CARDIOVASCULARES.
AR052926A1 (es) Forma cristalina gama del clorhidrato de ivabradina, un procedimiento para su preparacion y composiciones que la contienen
BR112013004920A2 (pt) "composições pesticidas".
SV2008003088A (es) Nueva forma cristalina vi de la agomelatina, su procedimiento de preparacion y las composiciones farmaceuticas que la contienen
HRP20171175T1 (hr) Novi triciklički spojevi
FI2049506T4 (fi) Lääkkeellisten aineiden farmakokineettisten ominaisuuksien modulaattorit
GB0601744D0 (en) Organic compounds
PH12014502397A1 (en) Pesticidal compositions and processes related thereto
BR112013010320B8 (pt) Composições pesticidas.
MX346665B (es) Composiciones pesticidas y procedimientos relacionados con estas.
BRPI0603043A (pt) forma cristalina iv de agomelatina, um processo para sua preparação e composições farmacêuticas contendo-a
UA102817C2 (ru) Способ синтеза агомелатина
BRPI0708278B8 (pt) forma cristalina "a" do sal de arginina de perindopril, seu uso, processo para sua preparação e composição farmacêutica
MX2011010547A (es) Composiciones farmaceuticas estables de diclofenaco.
NI201200194A (es) Forma cristalina delta de la sal de arginina de perindoprilo, su procedimiento de preparación, y las composiciones farmacéuticas que la contienen
ATE481393T1 (de) Neue cycloalkyl-benzothiadiazin-derivate, ihr herstellungsverfahren und die pharmazeutischen zusammensetzungen, die sie enthalten
CU20060195A7 (es) Forma cristalina delta-d del clorhidrato de la ivabradina, su procedimiento de preparación, y las composiciones farmacéuticas que lo contienen
FR2884517B1 (fr) Procede de preparation d'alcoxamines par photolyse de dithiocarbamates
WO2014195970A9 (en) Novel pyrrole compounds with silicon incorporation
ATE480544T1 (de) Tetrazykline, ihr herstellungsverfahren, deren pharmazeutischen zusammensetzungen, die sie enthalten und deren verwendung als dopamin- rezeptoren liganden
TH128434A (th) กรรมวิธีใหม่สำหรับการสังเคราะห์ของอะโกมีลาทีน