CN113663123A - Liquid wound spray dressing and preparation method thereof - Google Patents
Liquid wound spray dressing and preparation method thereof Download PDFInfo
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- CN113663123A CN113663123A CN202111061442.3A CN202111061442A CN113663123A CN 113663123 A CN113663123 A CN 113663123A CN 202111061442 A CN202111061442 A CN 202111061442A CN 113663123 A CN113663123 A CN 113663123A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
- A61L26/0023—Polysaccharides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0004—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing inorganic materials
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0057—Ingredients of undetermined constitution or reaction products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0061—Use of materials characterised by their function or physical properties
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0061—Use of materials characterised by their function or physical properties
- A61L26/0066—Medicaments; Biocides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0061—Use of materials characterised by their function or physical properties
- A61L26/0076—Sprayable compositions
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/10—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing inorganic materials
- A61L2300/11—Peroxy compounds, peroxides, e.g. hydrogen peroxide
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/202—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials with halogen atoms, e.g. triclosan, povidone-iodine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/216—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials with other specific functional groups, e.g. aldehydes, ketones, phenols, quaternary phosphonium groups
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/23—Carbohydrates
- A61L2300/236—Glycosaminoglycans, e.g. heparin, hyaluronic acid, chondroitin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/30—Compounds of undetermined constitution extracted from natural sources, e.g. Aloe Vera
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/402—Anaestetics, analgesics, e.g. lidocaine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/412—Tissue-regenerating or healing or proliferative agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/428—Vitamins, e.g. tocopherol, riboflavin
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Abstract
The invention discloses a liquid wound spray dressing and a preparation method thereof, and the liquid wound spray dressing comprises the following components in parts by weight: the wound healing lotion comprises a cosolvent, wound sterilizing liquid, wound repairing liquid and a preservative, wherein the cosolvent comprises high-purity water, 95% ethanol, acetamide, menthol and sodium salicylate, the wound sterilizing liquid comprises high-purity water, chitosan, hydrogen peroxide, sodium hypochlorite, norfloxacin and glycerol, and the wound repairing liquid comprises high-purity water, aloe extract, vitamin C, vitamin E and glycerol; a method for preparing liquid wound spray dressing. The method comprises the following steps: a) heating and stirring the wound sterilizing liquid and the wound repairing liquid in a water bath; b) adding a cosolvent into the mixed liquid obtained in the step a); c) adjusting the pH value; d) adding antiseptic. The invention relates to the field of wound treatment medicines, and particularly provides a liquid wound spray dressing which is simple and convenient to prepare, takes effect quickly and is beneficial to wound repair and a preparation method thereof.
Description
Technical Field
The invention relates to the field of wound treatment medicines, in particular to a liquid wound spray dressing and a preparation method thereof.
Background
The skin is the first layer of protection of a human body, so that most harmful bacteria can be prevented from invading into the body of people, people can difficultly avoid injuring themselves by some sharp objects in daily life activities or participating in sports, the skin is damaged, some harmful bacteria can invade the body of people directly from wounds, although the immune system in the body of people can quickly react to treat the wounds and eliminate part of bacteria, the immune system of people has no pertinence to bacteria, the problem that the wounds are infected by bacteria can possibly occur, the wounds can be healed slowly, scars can be left after the wounds heal, and the long-time repair is needed; when the wound is severe, the pain nerve feeds back a wound signal to the brain continuously, and people sometimes feel intolerable pain.
Disclosure of Invention
Aiming at the situation, in order to make up for the existing defects, the invention provides the liquid wound spray dressing which is simple and convenient to prepare, takes effect quickly and is beneficial to wound repair and the preparation method thereof.
The invention provides the following technical scheme: the invention relates to a liquid wound spray dressing which comprises the following components in parts by weight: 6-15 parts of cosolvent, 2-10 parts of wound sterilizing liquid, 2-10 parts of wound repairing liquid and 1 part of preservative, wherein the cosolvent comprises 20-30 parts of high-purity water, 10-20 parts of 95% ethanol, 5-15 parts of acetamide, 1-7 parts of menthol and 1-7 parts of sodium salicylate; the wound sterilizing liquid comprises 20-30 parts of high-purity water, 1-6 parts of chitosan, 1-6 parts of hydrogen peroxide, 1-6 parts of sodium hypochlorite, 0.5-2 parts of norfloxacin and 8-15 parts of glycerol, and the wound repairing liquid comprises 5-20 parts of high-purity water, 10-30 parts of aloe extract, 0.5-2 parts of vitamin C, 0.5-2 parts of vitamin E and 1-7 parts of glycerol; the preservative is isopropanol.
Preferably, the liquid wound spray dressing comprises the following components in parts by weight: 8-11 parts of cosolvent, 4-7 parts of wound sterilizing liquid, 4-7 parts of wound repairing liquid and 1 part of preservative, wherein the cosolvent comprises 20-25 parts of high-purity water, 10-15 parts of 95% ethanol, 5-10 parts of acetamide, 1-5 parts of menthol and 1-5 parts of sodium salicylate; the wound sterilizing liquid comprises 20-25 parts of high-purity water, 2-4 parts of chitosan, 2-4 parts of hydrogen peroxide, 2-4 parts of sodium hypochlorite, 0.5-1 part of norfloxacin and 5-10 parts of glycerol, and the wound repairing liquid comprises 5-15 parts of high-purity water, 20-30 parts of aloe extract, 0.5-1 part of vitamin C, 0.5-1 part of vitamin E and 2-4 parts of glycerol; the preservative is isopropanol.
Preferably, the liquid wound spray dressing comprises the following components in parts by weight: 9 parts of cosolvent, 5 parts of wound sterilizing liquid, 5 parts of wound repairing liquid and 1 part of preservative, wherein the cosolvent comprises 20 parts of high-purity water, 12 parts of 95% ethanol, 7 parts of acetamide, 3 parts of menthol and 3 parts of sodium salicylate; the wound sterilizing liquid comprises 20 parts of high-purity water, 3 parts of chitosan, 3 parts of hydrogen peroxide, 3 parts of sodium hypochlorite, 0.7 part of norfloxacin and 7 parts of glycerol, and the wound repairing liquid comprises 13 parts of high-purity water, 25 parts of aloe extract, 0.8 part of vitamin C, 0.8 part of vitamin E and 3 parts of glycerol; the preservative is isopropanol.
A preparation method of the liquid wound spray dressing specifically comprises the following steps:
a) placing the wound sterilizing liquid and the wound repairing liquid in a constant-temperature water bath, adding a stirrer with a set speed, heating and stirring in a water bath, stirring for 30min, removing the constant-temperature water bath, and continuously stirring for 1 h;
b) adding a cosolvent into the mixed liquid obtained in the step a), and continuously stirring for 30min in a constant-temperature water bath kettle;
c) adjusting the pH value of a mixed liquid of the cosolvent, the wound sterilizing liquid and the wound repairing liquid to 6.5-7.3, and uniformly stirring;
d) adding antiseptic, and stirring.
Wherein the temperature of the water bath in the step a) is 70-80 ℃. Step b) the water bath temperature is not higher than 65 ℃. The stirring in steps a) to d) was carried out in a closed vessel at a stirring speed of 60 prm.
The invention with the structure has the following beneficial effects: the liquid wound spray dressing contains a cooling component, can effectively reduce the pain degree of people caused by wounds, contains an antibacterial and bactericidal component, can effectively eliminate bacteria in the wounds, and also contains a wound repair component, so that the wounds can be repaired to the maximum extent; and the preparation process flow is simple, and the raw materials are common materials, so that the quantitative production is convenient.
Detailed Description
The invention is further illustrated by the following examples.
Example 1
A liquid wound spray dressing comprises the following components in parts by weight: 9 parts of cosolvent, 5 parts of wound sterilizing liquid, 5 parts of wound repairing liquid and 1 part of preservative, wherein the cosolvent comprises 20 parts of high-purity water, 12 parts of 95% ethanol, 7 parts of acetamide, 3 parts of menthol and 3 parts of sodium salicylate; the wound sterilizing liquid comprises 20 parts of high-purity water, 3 parts of chitosan, 3 parts of hydrogen peroxide, 3 parts of sodium hypochlorite, 0.7 part of norfloxacin and 7 parts of glycerol, and the wound repairing liquid comprises 13 parts of high-purity water, 25 parts of aloe extract, 0.8 part of vitamin C, 0.8 part of vitamin E and 3 parts of glycerol; the preservative is isopropanol.
A preparation method of the liquid wound spray dressing specifically comprises the following steps:
a) placing the wound sterilizing liquid and the wound repairing liquid in a constant-temperature water bath, adding a stirrer with a set speed, heating and stirring in a water bath, stirring for 30min, removing the constant-temperature water bath, and continuously stirring for 1 h;
b) adding a cosolvent into the mixed liquid obtained in the step a), and continuously stirring for 30min in a constant-temperature water bath kettle;
c) adjusting the pH value of a mixed liquid of the cosolvent, the wound sterilizing liquid and the wound repairing liquid to 6.5-7.3, and uniformly stirring;
d) adding antiseptic, and stirring.
Wherein the temperature of the water bath in the step a) is 70-80 ℃. Step b) the water bath temperature is not higher than 65 ℃. The stirring in steps a) to d) was carried out in a closed vessel at a stirring speed of 60 prm.
Example 2
A liquid wound spray dressing comprises the following components in parts by weight: 8-11 parts of cosolvent, 4-7 parts of wound sterilizing liquid, 4-7 parts of wound repairing liquid and 1 part of preservative, wherein the cosolvent comprises 20-25 parts of high-purity water, 10-15 parts of 95% ethanol, 5-10 parts of acetamide, 1-5 parts of menthol and 1-5 parts of sodium salicylate; the wound sterilizing liquid comprises 20-25 parts of high-purity water, 2-4 parts of chitosan, 2-4 parts of hydrogen peroxide, 2-4 parts of sodium hypochlorite, 0.5-1 part of norfloxacin and 5-10 parts of glycerol, and the wound repairing liquid comprises 5-15 parts of high-purity water, 20-30 parts of aloe extract, 0.5-1 part of vitamin C, 0.5-1 part of vitamin E and 2-4 parts of glycerol; the preservative is isopropanol.
A preparation method of the liquid wound spray dressing specifically comprises the following steps:
a) placing the wound sterilizing liquid and the wound repairing liquid in a constant-temperature water bath, adding a stirrer with a set speed, heating and stirring in a water bath, stirring for 30min, removing the constant-temperature water bath, and continuously stirring for 1 h;
b) adding a cosolvent into the mixed liquid obtained in the step a), and continuously stirring for 30min in a constant-temperature water bath kettle;
c) adjusting the pH value of a mixed liquid of the cosolvent, the wound sterilizing liquid and the wound repairing liquid to 6.5-7.3, and uniformly stirring;
d) adding antiseptic, and stirring.
Wherein the temperature of the water bath in the step a) is 70-80 ℃. Step b) the water bath temperature is not higher than 65 ℃. The stirring in steps a) to d) was carried out in a closed vessel at a stirring speed of 60 prm.
Example 3
A liquid wound spray dressing comprises the following components in parts by weight: 6-15 parts of cosolvent, 2-10 parts of wound sterilizing liquid, 2-10 parts of wound repairing liquid and 1 part of preservative, wherein the cosolvent comprises 20-30 parts of high-purity water, 10-20 parts of 95% ethanol, 5-15 parts of acetamide, 1-7 parts of menthol and 1-7 parts of sodium salicylate; the wound sterilizing liquid comprises 20-30 parts of high-purity water, 1-6 parts of chitosan, 1-6 parts of hydrogen peroxide, 1-6 parts of sodium hypochlorite, 0.5-2 parts of norfloxacin and 8-15 parts of glycerol, and the wound repairing liquid comprises 5-20 parts of high-purity water, 10-30 parts of aloe extract, 0.5-2 parts of vitamin C, 0.5-2 parts of vitamin E and 1-7 parts of glycerol; the preservative is isopropanol.
A preparation method of the liquid wound spray dressing specifically comprises the following steps:
a) placing the wound sterilizing liquid and the wound repairing liquid in a constant-temperature water bath, adding a stirrer with a set speed, heating and stirring in a water bath, stirring for 30min, removing the constant-temperature water bath, and continuously stirring for 1 h;
b) adding a cosolvent into the mixed liquid obtained in the step a), and continuously stirring for 30min in a constant-temperature water bath kettle;
c) adjusting the pH value of a mixed liquid of the cosolvent, the wound sterilizing liquid and the wound repairing liquid to 6.5-7.3, and uniformly stirring;
d) adding antiseptic, and stirring.
Wherein the temperature of the water bath in the step a) is 70-80 ℃. Step b) the water bath temperature is not higher than 65 ℃. The stirring in steps a) to d) was carried out in a closed vessel at a stirring speed of 60 prm.
It is noted that, herein, relational terms such as first and second, and the like may be used solely to distinguish one entity or action from another entity or action without necessarily requiring or implying any actual such relationship or order between such entities or actions. Also, the terms "comprises," "comprising," or any other variation thereof, are intended to cover a non-exclusive inclusion, such that a process, method, article, or apparatus that comprises a list of elements does not include only those elements but may include other elements not expressly listed or inherent to such process, method, article, or apparatus.
Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that changes, modifications, substitutions and alterations can be made in these embodiments without departing from the principles and spirit of the invention, the scope of which is defined in the appended claims and their equivalents.
Claims (7)
1. The liquid wound spray dressing is characterized by comprising the following components in parts by weight: 6-15 parts of cosolvent, 2-10 parts of wound sterilizing liquid, 2-10 parts of wound repairing liquid and 1 part of preservative, wherein the cosolvent comprises 20-30 parts of high-purity water, 10-20 parts of 95% ethanol, 5-15 parts of acetamide, 1-7 parts of menthol and 1-7 parts of sodium salicylate; the wound sterilizing liquid comprises 20-30 parts of high-purity water, 1-6 parts of chitosan, 1-6 parts of hydrogen peroxide, 1-6 parts of sodium hypochlorite, 0.5-2 parts of norfloxacin and 8-15 parts of glycerol, and the wound repairing liquid comprises 5-20 parts of high-purity water, 10-30 parts of aloe extract, 0.5-2 parts of vitamin C, 0.5-2 parts of vitamin E and 1-7 parts of glycerol; the preservative is isopropanol.
2. The liquid wound spray dressing of claim 1, comprising the following components in parts by weight: 8-11 parts of cosolvent, 4-7 parts of wound sterilizing liquid, 4-7 parts of wound repairing liquid and 1 part of preservative, wherein the cosolvent comprises 20-25 parts of high-purity water, 10-15 parts of 95% ethanol, 5-10 parts of acetamide, 1-5 parts of menthol and 1-5 parts of sodium salicylate; the wound sterilizing liquid comprises 20-25 parts of high-purity water, 2-4 parts of chitosan, 2-4 parts of hydrogen peroxide, 2-4 parts of sodium hypochlorite, 0.5-1 part of norfloxacin and 5-10 parts of glycerol, and the wound repairing liquid comprises 5-15 parts of high-purity water, 20-30 parts of aloe extract, 0.5-1 part of vitamin C, 0.5-1 part of vitamin E and 2-4 parts of glycerol; the preservative is isopropanol.
3. The liquid wound spray dressing of claim 1, comprising the following components in parts by weight: 9 parts of cosolvent, 5 parts of wound sterilizing liquid, 5 parts of wound repairing liquid and 1 part of preservative, wherein the cosolvent comprises 20 parts of high-purity water, 12 parts of 95% ethanol, 7 parts of acetamide, 3 parts of menthol and 3 parts of sodium salicylate; the wound sterilizing liquid comprises 20 parts of high-purity water, 3 parts of chitosan, 3 parts of hydrogen peroxide, 3 parts of sodium hypochlorite, 0.7 part of norfloxacin and 7 parts of glycerol, and the wound repairing liquid comprises 13 parts of high-purity water, 25 parts of aloe extract, 0.8 part of vitamin C, 0.8 part of vitamin E and 3 parts of glycerol; the preservative is isopropanol.
4. A preparation method of the liquid wound spray dressing is characterized by comprising the following steps:
a) placing the wound sterilizing liquid and the wound repairing liquid in a constant-temperature water bath, adding a stirrer with a set speed, heating and stirring in a water bath, stirring for 30min, removing the constant-temperature water bath, and continuously stirring for 1 h;
b) adding a cosolvent into the mixed liquid obtained in the step a), and continuously stirring for 30min in a constant-temperature water bath kettle;
c) adjusting the pH value of a mixed liquid of the cosolvent, the wound sterilizing liquid and the wound repairing liquid to 6.5-7.3, and uniformly stirring;
d) adding antiseptic, and stirring.
5. The method of preparing a liquid wound spray dressing according to claim 4, wherein the temperature of the water bath in step a) is 70-80 ℃.
6. The method of preparing a liquid wound spray dressing according to claim 4, wherein the temperature of the water bath in step b) is not higher than 65 ℃.
7. The method of claim 4, wherein the agitation in steps a) through d) is performed in a closed container at a rate of 60 prm.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202111061442.3A CN113663123A (en) | 2021-09-10 | 2021-09-10 | Liquid wound spray dressing and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202111061442.3A CN113663123A (en) | 2021-09-10 | 2021-09-10 | Liquid wound spray dressing and preparation method thereof |
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| Publication Number | Publication Date |
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| CN113663123A true CN113663123A (en) | 2021-11-19 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN202111061442.3A Withdrawn CN113663123A (en) | 2021-09-10 | 2021-09-10 | Liquid wound spray dressing and preparation method thereof |
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| CN (1) | CN113663123A (en) |
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2021
- 2021-09-10 CN CN202111061442.3A patent/CN113663123A/en not_active Withdrawn
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