CN112438916A - Skin-care matrix with antioxidant effect and preparation method and application thereof - Google Patents
Skin-care matrix with antioxidant effect and preparation method and application thereof Download PDFInfo
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- CN112438916A CN112438916A CN201910811093.9A CN201910811093A CN112438916A CN 112438916 A CN112438916 A CN 112438916A CN 201910811093 A CN201910811093 A CN 201910811093A CN 112438916 A CN112438916 A CN 112438916A
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- antioxidant effect
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- 230000003078 antioxidant effect Effects 0.000 title claims abstract description 38
- 238000002360 preparation method Methods 0.000 title claims abstract description 7
- 239000011159 matrix material Substances 0.000 title claims description 24
- XMWRBQBLMFGWIX-UHFFFAOYSA-N C60 fullerene Chemical compound C12=C3C(C4=C56)=C7C8=C5C5=C9C%10=C6C6=C4C1=C1C4=C6C6=C%10C%10=C9C9=C%11C5=C8C5=C8C7=C3C3=C7C2=C1C1=C2C4=C6C4=C%10C6=C9C9=C%11C5=C5C8=C3C3=C7C1=C1C2=C4C6=C2C9=C5C3=C12 XMWRBQBLMFGWIX-UHFFFAOYSA-N 0.000 claims abstract description 43
- 229910003472 fullerene Inorganic materials 0.000 claims abstract description 43
- 239000013535 sea water Substances 0.000 claims abstract description 29
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 29
- AEMOLEFTQBMNLQ-VANFPWTGSA-N D-mannopyranuronic acid Chemical compound OC1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@@H]1O AEMOLEFTQBMNLQ-VANFPWTGSA-N 0.000 claims abstract description 23
- AIPVRBGBHQDAPX-UHFFFAOYSA-N hydroxy(methyl)silane Chemical compound C[SiH2]O AIPVRBGBHQDAPX-UHFFFAOYSA-N 0.000 claims abstract description 21
- 241000226556 Leontopodium alpinum Species 0.000 claims abstract description 18
- 239000000758 substrate Substances 0.000 claims abstract description 6
- 240000006688 Telosma cordata Species 0.000 claims description 13
- 235000017352 Telosma cordata Nutrition 0.000 claims description 13
- 235000013399 edible fruits Nutrition 0.000 claims description 13
- 239000002537 cosmetic Substances 0.000 claims description 11
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 claims description 10
- 240000005125 Myrtus communis Species 0.000 claims description 10
- 235000013418 Myrtus communis Nutrition 0.000 claims description 10
- 239000003814 drug Substances 0.000 claims description 6
- 239000000203 mixture Substances 0.000 claims description 6
- 238000003756 stirring Methods 0.000 claims description 6
- BUGBHKTXTAQXES-UHFFFAOYSA-N Selenium Chemical compound [Se] BUGBHKTXTAQXES-UHFFFAOYSA-N 0.000 claims description 5
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 claims description 5
- 229910052500 inorganic mineral Inorganic materials 0.000 claims description 5
- 229910052742 iron Inorganic materials 0.000 claims description 5
- 239000011707 mineral Substances 0.000 claims description 5
- 239000001267 polyvinylpyrrolidone Substances 0.000 claims description 5
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims description 5
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims description 5
- 229910052711 selenium Inorganic materials 0.000 claims description 5
- 239000011669 selenium Substances 0.000 claims description 5
- 239000011701 zinc Substances 0.000 claims description 5
- 229910052725 zinc Inorganic materials 0.000 claims description 5
- 241001253169 Asystasia gangetica Species 0.000 claims description 4
- PWHULOQIROXLJO-UHFFFAOYSA-N Manganese Chemical compound [Mn] PWHULOQIROXLJO-UHFFFAOYSA-N 0.000 claims description 4
- 238000001816 cooling Methods 0.000 claims description 4
- 238000001914 filtration Methods 0.000 claims description 4
- 239000011572 manganese Substances 0.000 claims description 4
- 229910052748 manganese Inorganic materials 0.000 claims description 4
- 230000001954 sterilising effect Effects 0.000 claims description 4
- 238000000034 method Methods 0.000 claims description 3
- 235000011446 Amygdalus persica Nutrition 0.000 claims description 2
- 244000144730 Amygdalus persica Species 0.000 claims description 2
- 241000208829 Sambucus Species 0.000 claims 1
- 244000045719 Syzygium Species 0.000 claims 1
- 235000012096 Syzygium samarangense Nutrition 0.000 claims 1
- 235000008995 european elder Nutrition 0.000 claims 1
- 230000003064 anti-oxidating effect Effects 0.000 abstract description 12
- 230000000694 effects Effects 0.000 abstract description 11
- 230000002195 synergetic effect Effects 0.000 abstract description 3
- 241000288784 Barleria cristata Species 0.000 abstract 1
- 210000003491 skin Anatomy 0.000 description 29
- 239000000243 solution Substances 0.000 description 25
- 239000003963 antioxidant agent Substances 0.000 description 18
- 235000006708 antioxidants Nutrition 0.000 description 16
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 10
- WQGWDDDVZFFDIG-UHFFFAOYSA-N pyrogallol Chemical compound OC1=CC=CC(O)=C1O WQGWDDDVZFFDIG-UHFFFAOYSA-N 0.000 description 10
- 150000003254 radicals Chemical class 0.000 description 9
- 238000002835 absorbance Methods 0.000 description 6
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 6
- 230000000052 comparative effect Effects 0.000 description 6
- 229910052760 oxygen Inorganic materials 0.000 description 6
- 239000001301 oxygen Substances 0.000 description 6
- 239000012085 test solution Substances 0.000 description 6
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 description 5
- -1 DPPH free radical Chemical class 0.000 description 5
- 229930003268 Vitamin C Natural products 0.000 description 5
- 229940079877 pyrogallol Drugs 0.000 description 5
- 235000019154 vitamin C Nutrition 0.000 description 5
- 239000011718 vitamin C Substances 0.000 description 5
- 239000012153 distilled water Substances 0.000 description 4
- HHEAADYXPMHMCT-UHFFFAOYSA-N dpph Chemical compound [O-][N+](=O)C1=CC([N+](=O)[O-])=CC([N+]([O-])=O)=C1[N]N(C=1C=CC=CC=1)C1=CC=CC=C1 HHEAADYXPMHMCT-UHFFFAOYSA-N 0.000 description 4
- 235000010755 mineral Nutrition 0.000 description 4
- 230000002000 scavenging effect Effects 0.000 description 4
- NLZUEZXRPGMBCV-UHFFFAOYSA-N Butylhydroxytoluene Chemical compound CC1=CC(C(C)(C)C)=C(O)C(C(C)(C)C)=C1 NLZUEZXRPGMBCV-UHFFFAOYSA-N 0.000 description 3
- GAMYVSCDDLXAQW-AOIWZFSPSA-N Thermopsosid Natural products O(C)c1c(O)ccc(C=2Oc3c(c(O)cc(O[C@H]4[C@H](O)[C@@H](O)[C@H](O)[C@H](CO)O4)c3)C(=O)C=2)c1 GAMYVSCDDLXAQW-AOIWZFSPSA-N 0.000 description 3
- 244000137773 Viola philippica Species 0.000 description 3
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- 235000010354 butylated hydroxytoluene Nutrition 0.000 description 3
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- 150000002212 flavone derivatives Chemical class 0.000 description 3
- 235000011949 flavones Nutrition 0.000 description 3
- 229930182470 glycoside Natural products 0.000 description 3
- 150000002338 glycosides Chemical class 0.000 description 3
- FJCOTRVRFQSFDP-UHFFFAOYSA-N leontopodic acid Natural products C=1C=C(O)C(O)=CC=1C=CC(=O)OC(C(OC(=O)C=CC=1C=C(O)C(O)=CC=1)C(O)=O)C(C(OC(=O)CC(O)C)C(O)=O)OC(=O)C=CC1=CC=C(O)C(O)=C1 FJCOTRVRFQSFDP-UHFFFAOYSA-N 0.000 description 3
- 238000002156 mixing Methods 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- 238000012360 testing method Methods 0.000 description 3
- VHBFFQKBGNRLFZ-UHFFFAOYSA-N vitamin p Natural products O1C2=CC=CC=C2C(=O)C=C1C1=CC=CC=C1 VHBFFQKBGNRLFZ-UHFFFAOYSA-N 0.000 description 3
- 239000004322 Butylated hydroxytoluene Substances 0.000 description 2
- 102000004190 Enzymes Human genes 0.000 description 2
- 108090000790 Enzymes Proteins 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- IAJILQKETJEXLJ-UHFFFAOYSA-N Galacturonsaeure Natural products O=CC(O)C(O)C(O)C(O)C(O)=O IAJILQKETJEXLJ-UHFFFAOYSA-N 0.000 description 2
- 241000354044 Leontopodium japonicum Species 0.000 description 2
- OUUQCZGPVNCOIJ-UHFFFAOYSA-M Superoxide Chemical compound [O-][O] OUUQCZGPVNCOIJ-UHFFFAOYSA-M 0.000 description 2
- FPIPGXGPPPQFEQ-OVSJKPMPSA-N all-trans-retinol Chemical compound OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-OVSJKPMPSA-N 0.000 description 2
- 238000006701 autoxidation reaction Methods 0.000 description 2
- 210000000170 cell membrane Anatomy 0.000 description 2
- 230000008859 change Effects 0.000 description 2
- 210000002808 connective tissue Anatomy 0.000 description 2
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- 238000011161 development Methods 0.000 description 2
- 230000018109 developmental process Effects 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- PSFDQSOCUJVVGF-UHFFFAOYSA-N harman Chemical compound C12=CC=CC=C2NC2=C1C=CN=C2C PSFDQSOCUJVVGF-UHFFFAOYSA-N 0.000 description 2
- 239000004615 ingredient Substances 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 210000004927 skin cell Anatomy 0.000 description 2
- GEHJYWRUCIMESM-UHFFFAOYSA-L sodium sulfite Chemical compound [Na+].[Na+].[O-]S([O-])=O GEHJYWRUCIMESM-UHFFFAOYSA-L 0.000 description 2
- 238000005728 strengthening Methods 0.000 description 2
- 238000006467 substitution reaction Methods 0.000 description 2
- FPIPGXGPPPQFEQ-UHFFFAOYSA-N 13-cis retinol Natural products OCC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-UHFFFAOYSA-N 0.000 description 1
- QKNYBSVHEMOAJP-UHFFFAOYSA-N 2-amino-2-(hydroxymethyl)propane-1,3-diol;hydron;chloride Chemical compound Cl.OCC(N)(CO)CO QKNYBSVHEMOAJP-UHFFFAOYSA-N 0.000 description 1
- GOLORTLGFDVFDW-UHFFFAOYSA-N 3-(1h-benzimidazol-2-yl)-7-(diethylamino)chromen-2-one Chemical compound C1=CC=C2NC(C3=CC4=CC=C(C=C4OC3=O)N(CC)CC)=NC2=C1 GOLORTLGFDVFDW-UHFFFAOYSA-N 0.000 description 1
- CWVRJTMFETXNAD-FWCWNIRPSA-N 3-O-Caffeoylquinic acid Natural products O[C@H]1[C@@H](O)C[C@@](O)(C(O)=O)C[C@H]1OC(=O)\C=C\C1=CC=C(O)C(O)=C1 CWVRJTMFETXNAD-FWCWNIRPSA-N 0.000 description 1
- PZIRUHCJZBGLDY-UHFFFAOYSA-N Caffeoylquinic acid Natural products CC(CCC(=O)C(C)C1C(=O)CC2C3CC(O)C4CC(O)CCC4(C)C3CCC12C)C(=O)O PZIRUHCJZBGLDY-UHFFFAOYSA-N 0.000 description 1
- 241000207199 Citrus Species 0.000 description 1
- 230000005778 DNA damage Effects 0.000 description 1
- 231100000277 DNA damage Toxicity 0.000 description 1
- 235000012097 Eugenia cumini Nutrition 0.000 description 1
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- CWVRJTMFETXNAD-KLZCAUPSSA-N Neochlorogenin-saeure Natural products O[C@H]1C[C@@](O)(C[C@@H](OC(=O)C=Cc2ccc(O)c(O)c2)[C@@H]1O)C(=O)O CWVRJTMFETXNAD-KLZCAUPSSA-N 0.000 description 1
- 241000199919 Phaeophyceae Species 0.000 description 1
- 230000002292 Radical scavenging effect Effects 0.000 description 1
- 235000011341 Sideroxylon dulcificum Nutrition 0.000 description 1
- 240000007326 Thaumatococcus daniellii Species 0.000 description 1
- 235000005266 Thaumatococcus daniellii Nutrition 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 238000003915 air pollution Methods 0.000 description 1
- 230000003712 anti-aging effect Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 239000007853 buffer solution Substances 0.000 description 1
- 229940095259 butylated hydroxytoluene Drugs 0.000 description 1
- 125000004432 carbon atom Chemical group C* 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 230000003822 cell turnover Effects 0.000 description 1
- 235000001368 chlorogenic acid Nutrition 0.000 description 1
- CWVRJTMFETXNAD-JUHZACGLSA-N chlorogenic acid Chemical compound O[C@@H]1[C@H](O)C[C@@](O)(C(O)=O)C[C@H]1OC(=O)\C=C\C1=CC=C(O)C(O)=C1 CWVRJTMFETXNAD-JUHZACGLSA-N 0.000 description 1
- 229940074393 chlorogenic acid Drugs 0.000 description 1
- FFQSDFBBSXGVKF-KHSQJDLVSA-N chlorogenic acid Natural products O[C@@H]1C[C@](O)(C[C@@H](CC(=O)C=Cc2ccc(O)c(O)c2)[C@@H]1O)C(=O)O FFQSDFBBSXGVKF-KHSQJDLVSA-N 0.000 description 1
- BMRSEYFENKXDIS-KLZCAUPSSA-N cis-3-O-p-coumaroylquinic acid Natural products O[C@H]1C[C@@](O)(C[C@@H](OC(=O)C=Cc2ccc(O)cc2)[C@@H]1O)C(=O)O BMRSEYFENKXDIS-KLZCAUPSSA-N 0.000 description 1
- 235000020971 citrus fruits Nutrition 0.000 description 1
- 230000037319 collagen production Effects 0.000 description 1
- 239000006071 cream Substances 0.000 description 1
- MGJZITXUQXWAKY-UHFFFAOYSA-N diphenyl-(2,4,6-trinitrophenyl)iminoazanium Chemical compound [O-][N+](=O)C1=CC([N+](=O)[O-])=CC([N+]([O-])=O)=C1N=[N+](C=1C=CC=CC=1)C1=CC=CC=C1 MGJZITXUQXWAKY-UHFFFAOYSA-N 0.000 description 1
- 239000000839 emulsion Substances 0.000 description 1
- 230000001815 facial effect Effects 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 230000007760 free radical scavenging Effects 0.000 description 1
- 239000000499 gel Substances 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 239000002085 irritant Substances 0.000 description 1
- 231100000021 irritant Toxicity 0.000 description 1
- 229940118618 leontopodium alpinum extract Drugs 0.000 description 1
- 230000003859 lipid peroxidation Effects 0.000 description 1
- 150000002660 luteolin derivatives Chemical class 0.000 description 1
- WPBNNNQJVZRUHP-UHFFFAOYSA-L manganese(2+);methyl n-[[2-(methoxycarbonylcarbamothioylamino)phenyl]carbamothioyl]carbamate;n-[2-(sulfidocarbothioylamino)ethyl]carbamodithioate Chemical compound [Mn+2].[S-]C(=S)NCCNC([S-])=S.COC(=O)NC(=S)NC1=CC=CC=C1NC(=S)NC(=O)OC WPBNNNQJVZRUHP-UHFFFAOYSA-L 0.000 description 1
- 150000007524 organic acids Chemical class 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 150000002926 oxygen Chemical class 0.000 description 1
- 239000000575 pesticide Substances 0.000 description 1
- 230000002633 protecting effect Effects 0.000 description 1
- 230000002285 radioactive effect Effects 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 230000008929 regeneration Effects 0.000 description 1
- 238000011069 regeneration method Methods 0.000 description 1
- 230000008521 reorganization Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 238000012827 research and development Methods 0.000 description 1
- 229960003471 retinol Drugs 0.000 description 1
- 235000020944 retinol Nutrition 0.000 description 1
- 239000011607 retinol Substances 0.000 description 1
- 239000012488 sample solution Substances 0.000 description 1
- 150000004819 silanols Chemical class 0.000 description 1
- 230000009759 skin aging Effects 0.000 description 1
- 230000008591 skin barrier function Effects 0.000 description 1
- 230000000391 smoking effect Effects 0.000 description 1
- 235000010265 sodium sulphite Nutrition 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 239000011573 trace mineral Substances 0.000 description 1
- 235000013619 trace mineral Nutrition 0.000 description 1
- 235000015112 vegetable and seed oil Nutrition 0.000 description 1
- 239000008158 vegetable oil Substances 0.000 description 1
- 238000003911 water pollution Methods 0.000 description 1
- 230000002087 whitening effect Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/58—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing atoms other than carbon, hydrogen, halogen, oxygen, nitrogen, sulfur or phosphorus
- A61K8/585—Organosilicon compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
- A61K8/817—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a single or double bond to nitrogen or by a heterocyclic ring containing nitrogen; Compositions or derivatives of such polymers, e.g. vinylimidazol, vinylcaprolactame, allylamines (Polyquaternium 6)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/965—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of inanimate origin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Birds (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Dermatology (AREA)
- Gerontology & Geriatric Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Inorganic Chemistry (AREA)
- Medicines Containing Plant Substances (AREA)
- Cosmetics (AREA)
Abstract
The invention provides a skin-care substrate with an anti-oxidation effect and a preparation method and application thereof, and the technical scheme mainly comprises 4-10 parts of a philippine violet herb extract, 5-10 parts of a alpine edelweiss extract, 8-15 parts of fullerene, 10-30 parts of methylsilanol mannuronate, 20-40 parts of seawater and 15-28 parts of water; the substrate reasonably matches functional components and optimizes the dosage of the functional components, so that the active components realize complementation and synergistic effect, and a good antioxidant effect is achieved; belongs to the technical field of skin care products.
Description
Technical Field
The invention relates to a skin-care matrix with an antioxidant effect, a preparation method and application thereof, and belongs to the technical field of skin-care products.
Background
The earliest references to "antioxidant" in the cosmetics industry refer to maintaining the stability of the body by antioxidants. For example, many vegetable oils contain unsaturated double bonds and are subject to rancidity and spoilage due to oxidation by oxygen; many active ingredients, such as retinol, are unstable in the presence of oxygen and require antioxidants to stabilize activity. Commonly used antioxidants include sodium sulfite, BHT (Butylated hydroxytoluene,2, 6-di-tert-butyl-4-methylphenol), and the like.
With the development of the cosmetic industry, the concept of "skin needs to be antioxidant" was introduced. People add antioxidants in food and medicine industries into cosmetics to enhance the antioxidant capacity of skin through external application, and hope to achieve better whitening and anti-aging capacity. This stems from the theory of free radicals associated with aging. The founder of the theory of free radicals, haman (Harman), believes that aging is closely related to excessive oxygen free radicals and/or decreased scavenging ability in the body, and the free radicals directly determine the health and aging of the human body. The ability of the human body to scavenge free radicals is also known as the antioxidant capacity. Meanwhile, the older the age, the lower the antioxidant capacity of the human body; and external factors such as smoking, air pollution, water pollution, radioactive rays (x rays and ultraviolet rays), pesticides, high living pressure, excessive movement and the like all cause the concentration of free radicals in the body to be greatly increased, and at the moment, an anti-oxidation system in the body also faces the crisis of insufficient use. Therefore, the antioxidant skin care product is listed as one of the main research and development directions by cosmetic enterprises and is also one of the most important functional requirements of market consumers.
Disclosure of Invention
In view of the above problems, it is a first object of the present invention to provide a skin care base having antioxidant effect.
Another object of the present invention is to provide a method for preparing the skin care base with antioxidant effect.
It is a final object of the present invention to provide the use of the above skin care base having antioxidant effect.
The purpose of the invention is realized by the following technical scheme:
a skin care matrix with an anti-oxidation effect mainly comprises the following components in parts by weight: 4-10 parts of a Chinese violet extract, 5-10 parts of a alpine edelweiss extract, 8-15 parts of a fullerene solution, 10-30 parts of methylsilanol mannuronate, 20-40 parts of seawater and 15-28 parts of water.
Furthermore, the skin care matrix also comprises 3-8 parts of the extract of the suspected myrtle fruit.
Preferably, the skin care matrix consists of the following components in parts by weight: the traditional Chinese medicine composition comprises, by weight, 7 parts of a philippine violet herb extract, 8 parts of a alpine edelweiss extract, 12 parts of a fullerene solution, 20 parts of methylsilanol mannuronate, 30 parts of seawater, 5 parts of a suspected myrtle fruit extract and 18 parts of water.
Preferably, the total content of minerals in the seawater is 10000-13000ppm, wherein the total content of zinc, iron, manganese and selenium is 0.02-0.06 ppm.
Preferably, the fullerene solution is a water-soluble fullerene solution dispersed by using polyvinylpyrrolidone, and the fullerene content of the fullerene solution is 0.01-0.03 wt%.
The invention also provides a preparation method of the skin care matrix with the antioxidant effect, which comprises the following steps:
(1) sterilizing water at high temperature, and cooling to 40-45 deg.C;
(2) adding the Chinese violet extract, the edelweiss extract, the fullerene solution, the methylsilanol mannuronate and the seawater into the water obtained in the step (1), stirring and filtering to obtain the skin-care substrate with the antioxidant effect.
Further, the step (2) also comprises adding the extract of the suspected myrtle fruit into the water obtained in the step (1) and uniformly stirring.
The invention also provides application of the skin care matrix with the antioxidant effect in cosmetics.
Further, the weight percentage of the skin care matrix in the cosmetic is 3-15%.
The Chinese violet extract contains more than 10 effective components of flavone and its glycosides, organic acid, coumarin, etc. the flavone and its glycosides are the main components, and the research shows that the Chinese violet extract has excellent free radical scavenging activity and strong antioxidant activity.
The extract of edelweiss contains a large amount of leontopodic acid, chlorogenic acid and luteolin derivatives, providing a strong ability to protect and regenerate the skin barrier, in particular leontopodic acid, which is a component first found in edelweiss and has extraordinary antioxidant, radical scavenging and DNA protecting properties.
The fullerene is a football-shaped molecule consisting of 60 carbon atoms and has a diameter of about 0.7nm, and the fullerene used in the invention is a water-soluble fullerene solution dispersed by water-soluble high-molecular polyvinylpyrrolidone, and the effective content of the fullerene is less than 0.03%. The fullerene has super-strong antioxidant capacity which is about 172 times of vitamin C, and the duration of the antioxidant capacity is more than 11 hours, so that active oxygen generated under various conditions can be eliminated, and the super-strong antioxidant capacity can still be stably exerted under the irradiation of ultraviolet rays.
Methylsilanol mannuronate is synthesized from semi-natural silanols, which are organic derivatives of silicon, and mannuronic acid, which are natural components of human connective tissue and enhance cell regeneration, connective tissue reorganization, stimulation of cell turnover and collagen production. The mannuronic acid is extracted from brown algae, and has strong antioxidant effect. Methylsilanol mannuronate protects skin cells from damage caused by free radical attack by strengthening the cell membrane.
The seawater selected by the invention is lava seawater from the Jizhou island, the seawater is filtered by the unique geological structure of the Jizhou island, and contains a plurality of special mineral substances, such as zinc, iron, manganese, selenium and the like, the total content of the mineral substances is 0.02-0.06ppm, and the content of the mineral substances is obviously higher than that of the seawater from the sea and deep seawater. The seawater is rich in zinc, iron, manganese and selenium which are trace elements forming antioxidant enzyme, and can neutralize active oxygen clusters, so that the seawater has better antioxidation.
Suspected Syzygium cumini, also called Carm fruit, is a unique "miracle fruit" of Amazon Valley, and is the reputation of "the king of natural vitamin C" or "vitamin C fruit king". The extract is rich in natural vitamin C with high concentration, 30 times of that of citrus, has strong antioxidant activity, and can eliminate free radical, and reduce DNA damage and lipid peroxidation related to ultraviolet ray.
Compared with the prior art, the invention has the following advantages and beneficial effects:
according to the invention, the viola yedoensis makino extract, the leontopodium alpinum extract and the myrtle fruit extract have strong antioxidant activity through the contained effective components such as flavone and glycosides thereof, leontopodic acid, vitamin C and the like, and are natural and non-irritant; the fullerene is water-soluble fullerene, has super-strong antioxidant capacity, can eliminate active oxygen generated under various conditions, and can still stably exert the super-strong antioxidant capacity under the irradiation of ultraviolet rays; methylsilanol mannuronate protects skin cells from damage caused by free radical attack by strengthening cell membranes; the seawater contains zinc, iron, manganese and selenium microelements which form antioxidant enzyme, and can neutralize active oxygen cluster, so that the seawater has good antioxidation effect. The invention adopts the components as main functional components, and achieves good antioxidation by the mutual action of the components, namely the synergistic effect. The skin care matrix prepared by the invention is added into cosmetics such as cream, emulsion, gel, facial mask and the like, so that the skin care matrix brings good antioxidant effect to the cosmetics and prevents skin aging.
Detailed Description
The following claims are provided to illustrate the invention in further detail in connection with the detailed description of the invention, but not to limit the invention in any way.
It should be noted that the raw materials provided by the present invention are all commercially available.
Example 1
A skin care matrix with an anti-oxidation effect comprises the following components in parts by weight: 4 parts of Chinese violet extract, 8 parts of alpine edelweiss extract, 8 parts of fullerene solution (the content of fullerene is 0.02 wt%), 30 parts of methylsilanol mannuronate, 22 parts of seawater and 28 parts of water.
Example 2
A skin care matrix with an anti-oxidation effect comprises the following components in parts by weight: 5 parts of Chinese violet extract, 10 parts of alpine edelweiss extract, 15 parts of fullerene solution (the content of fullerene is 0.01 wt%), 10 parts of methylsilanol mannuronate, 40 parts of seawater and 20 parts of water.
Example 3
A skin care matrix with an anti-oxidation effect comprises the following components in parts by weight: the traditional Chinese medicine composition comprises, by weight, 7 parts of a philippine violet herb extract, 8 parts of a alpine edelweiss extract, 12 parts of a fullerene solution (the content of fullerene is 0.03 wt%), 20 parts of methylsilanol mannuronate, 30 parts of seawater and 23 parts of water.
The skin care bases of examples 1 to 3 were prepared as follows:
(1) sterilizing water at high temperature, and cooling to 40-45 deg.C;
(2) adding the Chinese violet extract, the edelweiss extract, the fullerene solution, the methylsilanol mannuronate and the seawater into the water obtained in the step (1), stirring and filtering to obtain the skin-care substrate with the antioxidant effect.
Example 4
A skin care matrix with an anti-oxidation effect comprises the following components in parts by weight: 10 parts of Chinese violet extract, 5 parts of alpine edelweiss extract, 9 parts of fullerene solution (the content of fullerene is 0.02 wt%), 15 parts of methylsilanol mannuronate, 34 parts of seawater, 3 parts of suspected myrtle fruit extract and 24 parts of water.
Example 5
A skin care matrix with an anti-oxidation effect comprises the following components in parts by weight: 6 parts of Chinese violet extract, 9 parts of alpine edelweiss extract, 14 parts of fullerene solution (the content of fullerene is 0.01 wt%), 28 parts of methylsilanol mannuronate, 20 parts of seawater, 8 parts of suspected myrtle fruit extract and 15 parts of water.
Example 6
A skin care matrix with an anti-oxidation effect comprises the following components in parts by weight: the traditional Chinese medicine composition comprises, by weight, 7 parts of a philippine violet herb extract, 8 parts of a alpine edelweiss extract, 12 parts of a fullerene solution (the content of fullerene is 0.03 wt%), 20 parts of methylsilanol mannuronate, 30 parts of seawater, 5 parts of a suspected myrtle fruit extract and 18 parts of water.
The skin care bases of examples 4 to 6 were prepared as follows:
(1) sterilizing water at high temperature, and cooling to 40-45 deg.C;
(2) adding the Chinese violet extract, the edelweiss extract, the fullerene solution, the methylsilanol mannuronate, the seawater and the suspected myrtle fruit extract into the water obtained in the step (1), stirring and filtering to obtain the skin-care substrate with the antioxidant effect.
The fullerene solution in the above embodiment is a water-soluble fullerene solution dispersed using polyvinylpyrrolidone.
To better illustrate the effects of the present invention, comparative examples of experimental protocols of the present invention during development are given below.
Comparative example 1
A skin care matrix consists of the following components in parts by weight: 12 parts of a fullerene solution (the fullerene solution is a water-soluble fullerene solution dispersed by polyvinylpyrrolidone, and the fullerene content is 0.03 wt%), 20 parts of methylsilanol mannuronate and 68 parts of water.
Comparative example 2
A skin care matrix consists of the following components in parts by weight: the traditional Chinese medicine composition comprises 7 parts of a Chinese violet extract, 8 parts of a alpine edelweiss extract, 30 parts of seawater and 55 parts of water.
Comparative example 3
A skin care matrix consists of the following components in parts by weight: 5 parts of suspected myrtle fruit extract and 95 parts of water.
The efficacy test of the invention:
the skin care bases prepared in examples 1 to 6 and comparative examples 1 to 3 were diluted with distilled water to 8% concentration sample solutions, respectively, as test solutions, and the following tests were performed:
1. experiment for scavenging DPPH free radical (DPPH. cndot.)
A DPPH solution having a concentration of 20mmol/L was prepared using absolute ethanol. 2mL of the test solution and 2mL of the DPPH solution were added to the same tube, shaken, and allowed to stand in the dark at room temperature for 30 minutes to determine the absorbance A1 at 517nm, and at the same time, the absorbance A2 at 517nm after mixing 2mL of the test solution with 2mL of absolute ethanol and the absorbance A3 at 517nm after mixing 2mL of the DPPH solution with 2mL of distilled water were determined. The clearance was calculated as follows.
The clearance (%) {1- [ (a 1-a 2)/A3] } × 100%.
2. Scavenging superoxide anion radical (O)2·-) Experiment of
Taking 4.5mL of 0.05mol/L Tris-HCl buffer solution with pH of 8.2 and 4.2mL of distilled water, uniformly mixing, placing in a water bath at 25 ℃, preserving the heat for 20min, taking out, immediately adding 0.3mL of 3mmol pyrogallol (prepared by 10mmol/L HCl and using 10mmol/L HCl as a blank tube to replace the HCl solution of the pyrogallol) preheated at 25 ℃, quickly shaking uniformly, pouring into a cuvette, measuring the absorbance once every 30s at 325nm, measuring for 5min totally, and calculating the change rate of the absorbance of the control solution along with the time A1 (the autoxidation rate of the pyrogallol).
Then, according to the above test, 1ml of the test solution was added before the pyrogallol was added, the volume of distilled water was decreased correspondingly, and the rate of change of absorbance with time after the addition of the test solution, a2 (the rate of autoxidation of the pyrogallol after the addition of the test solution), was calculated.
The clearance (%) [ (a 1-a 2)/a1] × 100%.
TABLE 1
As can be seen from Table 1, the skin care matrices of examples 1-6 of the present invention have a strong scavenging capacity for both DPPH radicals and superoxide anion radicals. Comparing examples 1-3 with examples 1-6, it can be seen that when the skin care matrix of the present invention contains only one, two or three of the ingredients selected from the group consisting of viola yedoensis makino extract, leontopodium japonicum extract, fullerene, methylsilanol mannuronate, seawater, and prunus persica fruit extract, the removal rate of DPPH radicals and superoxide anion radicals is significantly reduced, and the sum of the DPPH radical removal rates and the sum of the superoxide anion radical removal rates of comparative examples 1 and 2 are less than those of examples 1-6, which indicates that the skin care matrix of the present invention can achieve a good antioxidant effect through the synergistic effect of the five ingredients selected from the group consisting of viola yedoensis makino extract, leontopodium japonicum extract, fullerene, methylsilanol mannuronate, and seawater.
The above embodiments are preferred embodiments of the present invention, but the present invention is not limited to the above embodiments, and any other changes, modifications, substitutions, combinations, and simplifications which do not depart from the spirit and principle of the present invention should be construed as equivalents thereof, and all such changes, modifications, substitutions, combinations, and simplifications are intended to be included in the scope of the present invention.
Claims (9)
1. The skin care matrix with the antioxidant effect is characterized by mainly comprising the following components in parts by weight: 4-10 parts of a Chinese violet extract, 5-10 parts of a alpine edelweiss extract, 8-15 parts of a fullerene solution, 10-30 parts of methylsilanol mannuronate, 20-40 parts of seawater and 15-28 parts of water.
2. The skin care base according to claim 1, further comprising 3-8 parts of extract of prunus persica.
3. The skin care matrix of claim 2, consisting of the following components in parts by weight: the traditional Chinese medicine composition comprises, by weight, 7 parts of a philippine violet herb extract, 8 parts of a alpine edelweiss extract, 12 parts of a fullerene solution, 20 parts of methylsilanol mannuronate, 30 parts of seawater, 5 parts of a suspected myrtle fruit extract and 18 parts of water.
4. The skin care base according to any one of claims 1 to 3, wherein the total content of minerals in the seawater is 10000-13000ppm, wherein the total content of zinc, iron, manganese and selenium is 0.02-0.06 ppm.
5. The skin care base according to any one of claims 1 to 3, wherein the fullerene solution is a water-soluble fullerene solution dispersed using polyvinylpyrrolidone, and has a fullerene content of 0.01 to 0.03 wt%.
6. The method of preparing a skin care base having antioxidant effect of claim 1, comprising the steps of:
(1) sterilizing water at high temperature, and cooling to 40-45 deg.C;
(2) adding the Chinese violet extract, the edelweiss extract, the fullerene solution, the methylsilanol mannuronate and the seawater into the water obtained in the step (1), stirring and filtering to obtain the skin-care substrate with the antioxidant effect.
7. The method for preparing a skin care base according to claim 6, wherein the step (2) further comprises adding the extract of the Syzygium sambucus Hance into the water obtained in the step (1) and stirring the mixture uniformly.
8. Use of a skin care base according to any one of claims 1 to 3 having antioxidant effect in the preparation of a cosmetic product.
9. Use of the skin care base with antioxidant effect in the preparation of cosmetics according to claim 8, characterized in that the skin care base with antioxidant effect is present in the cosmetic in a weight percentage of 3-15%.
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| US20060134095A1 (en) * | 2003-01-27 | 2006-06-22 | Shinobu Ito | Antioxidative composition and composition for external use |
| US20080292689A1 (en) * | 2005-12-30 | 2008-11-27 | Lie-Ching Row | Method for inhibiting free radicals |
| CN106265371A (en) * | 2016-09-30 | 2017-01-04 | 广州赛莱拉干细胞科技股份有限公司 | Antioxidant cosmetic composition and preparation method thereof |
| CN106420445A (en) * | 2016-09-19 | 2017-02-22 | 广东丸美生物技术股份有限公司 | Skin care matrix with moisture preserving and oxidation resisting effects as well as preparation method and application of skin care matrix |
| CN109602665A (en) * | 2019-01-31 | 2019-04-12 | 广州艾蓓生物科技有限公司 | A kind of anti-oxidant Essence |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20060134095A1 (en) * | 2003-01-27 | 2006-06-22 | Shinobu Ito | Antioxidative composition and composition for external use |
| US20080292689A1 (en) * | 2005-12-30 | 2008-11-27 | Lie-Ching Row | Method for inhibiting free radicals |
| CN106420445A (en) * | 2016-09-19 | 2017-02-22 | 广东丸美生物技术股份有限公司 | Skin care matrix with moisture preserving and oxidation resisting effects as well as preparation method and application of skin care matrix |
| CN106265371A (en) * | 2016-09-30 | 2017-01-04 | 广州赛莱拉干细胞科技股份有限公司 | Antioxidant cosmetic composition and preparation method thereof |
| CN109602665A (en) * | 2019-01-31 | 2019-04-12 | 广州艾蓓生物科技有限公司 | A kind of anti-oxidant Essence |
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