CN111718687A

CN111718687A - Medical mirror surface anti-fog liquid and preparation method thereof, medical mirror surface anti-fog film and preparation method thereof, anti-fog method and medical instrument

Info

Publication number: CN111718687A
Application number: CN201911260181.0A
Authority: CN
Inventors: 宋健平; 莫关根
Original assignee: Hangzhou Huikang Medical Devices Co ltd
Current assignee: Hangzhou Huikang Medical Devices Co ltd
Priority date: 2019-12-10
Filing date: 2019-12-10
Publication date: 2020-09-29
Anticipated expiration: 2039-12-10
Also published as: CN111718687B

Abstract

The invention provides a medical mirror surface antifogging liquid and a preparation method thereof, a medical mirror surface antifogging film and a preparation method thereof, an antifogging method and medical instruments, and relates to the technical field of mirror surface antifogging. The medical mirror surface antifogging liquid is prepared by adopting an active agent, a slow release agent, a toughening agent and water with specific dosage, wherein a biological refining agent and ethanol are compounded to be used as the toughening agent, and polyhydric alcohol is used as the slow release agent and is in synergistic action with other components such as the active agent and the like; meanwhile, various raw materials of the medical mirror antifogging fluid are easy to obtain, the production cost is low, and the popularization and the application are facilitated. The invention also provides a medical mirror surface anti-fog film, a preparation method thereof and an anti-fog method.

Description

Medical mirror surface anti-fog liquid and preparation method thereof, medical mirror surface anti-fog film and preparation method thereof, anti-fog method and medical instrument

Technical Field

The invention relates to the technical field of mirror surface antifogging, in particular to a medical mirror surface antifogging liquid and a preparation method thereof, a medical mirror surface antifogging film and a preparation method thereof, an antifogging method and a medical instrument.

Background

With the continuous development of clinical medicine level, the minimally invasive surgery gradually permeates into clinical, nursing, imaging and inspection medicine aspects from the perspective of reducing the injury of patients. The concept of minimally invasive surgery refers to preoperative diagnosis and surgical treatment by using various modern medical instruments and related equipment such as endoscopes and endoscopes for different organs, and has the advantages of small wound, light pain and quick recovery. Among them, endoscopic imaging of the monitoring system is a key tool. However, the temperature inside the human body cavity is high, and the temperature difference exists between the human body cavity and the endoscope, so that the water vapor inside the human body cavity meets the cooler endoscope, and is easy to agglutinate on the lens, fog is generated, and the visual field of the endoscope is influenced. In order to ensure the normal operation of the operation, the endoscope is usually required to be subjected to antifogging treatment for many times in the actual operation process, so that the operation time is prolonged, and the pain of a patient is increased. Therefore, the condition that the fogging of the lens of the endoscope is avoided is the premise that the minimally invasive surgery is smoothly carried out, on one hand, the clear visual field is required to be ensured, the focus condition is accurately known, on the other hand, the surgery time can be shortened, and the pain of a patient is reduced.

In order to avoid fogging of the endoscope, medical staff and related scientific research staff adopt various anti-fogging methods, but the effect is not ideal. For example, the imported anti-fog oil is expensive, increases the burden of patients, has the problem of short anti-fog lasting time, needs repeated anti-fog treatment and prolongs the operation time; the hot salt water antifogging method is adopted, antifogging treatment needs to be repeated, and the service life of the endoscope lens can be shortened due to overhigh temperature; by adopting a povidone iodine antifogging method, part of patients can have iodine allergy, and colored iodophors can influence the judgment of doctors on focuses in the operation process to a certain extent. Therefore, in practical clinical application, a medical mirror surface antifogging treatment method with good antifogging effect, long lasting time and no harm to human bodies is still needed.

In view of the above, the present invention is particularly proposed to solve at least one of the above technical problems.

Disclosure of Invention

The first purpose of the invention is to provide a medical mirror antifogging liquid which has good antifogging effect, long lasting time and no harm to human body.

The second purpose of the invention is to provide a preparation method of the medical mirror antifogging fluid.

The third purpose of the invention is to provide a medical mirror surface antifogging film which is prepared by adopting the medical mirror surface antifogging liquid.

The fourth purpose of the invention is to provide a preparation method of the medical mirror antifogging film.

A fifth object of the present invention is to provide an anti-fogging method.

A sixth object of the present invention is to provide a medical instrument.

In order to achieve the purpose, the technical scheme of the invention is as follows:

the invention provides medical mirror antifogging liquid which comprises the following components in percentage by weight: 3-15% of active agent, 10-35% of slow release agent, 2-20% of toughening agent and 40-85% of water;

wherein the active agent comprises any one or the combination of at least two of sulfonic acid anionic surfactant, benzenesulfonic acid anionic surfactant, polyether modified silicone surfactant or polyoxyethylene type nonionic surfactant;

the sustained release agent comprises a polyhydric alcohol;

the toughening agent comprises a biological refining agent and ethanol, wherein the biological refining agent comprises any one or a combination of at least two of hyaluronate, chitosan or elastin peptide.

Further, on the basis of the technical scheme of the invention, the medical mirror antifogging fluid comprises the following components in percentage by weight: 3.5 to 14.9 percent of active agent, 11 to 34 percent of slow release agent, 3 to 16 percent of toughening agent and 45 to 80 percent of water;

preferably, the medical mirror antifogging fluid comprises the following components in percentage by weight: 5.0-14.8% of active agent, 12-33% of slow release agent, 5-12% of toughening agent and 47-75% of water.

Further, on the basis of the technical scheme of the invention, the mass ratio of the biological refining agent to the ethanol in the toughening agent is (0.05-5): (1-35);

preferably, the biorefining agent is a hyaluronate;

preferably, the hyaluronic acid salt comprises sodium hyaluronate;

preferably, the active agent comprises any one or a combination of at least two of sodium dodecyl benzene sulfonate, sodium hexadecyl sulfonate, sodium diisooctyl succinate sulfonate, polydimethylsiloxane, methyl hydrogen-containing silicone oil, methyl vinyl silicone oil, fatty alcohol-polyoxyethylene ether or alkylphenol polyoxyethylene ether;

preferably, the active agent comprises sodium dodecyl benzene sulfonate, polydimethylsiloxane and alkylphenol polyoxyethylene ether, and the mass ratio of the sodium dodecyl benzene sulfonate to the polydimethylsiloxane to the alkylphenol polyoxyethylene ether is (0.5-10): (1-15): (0.1-5);

preferably, the slow release agent comprises any one or a combination of at least two of glycerol, ethylene glycol, butanediol, isopropanol, propylene glycol or polyvinyl alcohol;

preferably, the sustained release agent comprises glycerol and ethylene glycol, wherein the mass ratio of the glycerol to the ethylene glycol is (1-15): (2-30);

preferably, the water is purified water.

The invention also provides a preparation method of the medical mirror antifogging liquid, which comprises the following steps:

mixing the active agent, the sustained-release agent, the toughening agent and water in proportion to obtain medical mirror surface antifogging solution;

preferably, stirring is carried out during mixing, the stirring speed is 15-50r/s, and the stirring time is 10-60 min;

preferably, the step of standing is also included after mixing;

preferably, the standing time is 1-24 h.

The invention also provides a medical mirror anti-fog film which is prepared from the medical mirror anti-fog liquid or the medical mirror anti-fog liquid prepared by the preparation method.

The invention also provides a preparation method of the medical mirror antifogging film, which comprises the following steps:

(a) wiping the medical mirror surface to be subjected to antifogging treatment by the wet carrier wetted by the medical mirror surface antifogging liquid, and then standing the medical mirror surface;

(b) and wiping the standing medical mirror surface by using a dry carrier to obtain the medical mirror surface antifogging film.

Further, on the basis of the technical scheme of the invention, in the step (a), the wet carrier wetted by the medical mirror antifogging fluid is prepared by the following steps:

soaking the carrier in the medical mirror surface antifogging liquid, and fully wetting to ensure that the weight gain rate of the carrier is 120-180 percent to obtain a wet carrier wetted by the medical mirror surface antifogging liquid;

preferably, in the step (a), the weight gain rate of the carrier is 137-178%;

preferably, in step (a), the wet film thickness is from 8 to 15 μm;

preferably, in step (a), the standing time is 3-5 min.

The invention also provides an anti-fog method for carrying out anti-fog treatment on the medical mirror surface by using the medical mirror surface anti-fog liquid, which comprises the following steps:

(a) wiping the medical mirror surface to be subjected to antifogging treatment with the wet carrier wetted by the medical mirror surface antifogging liquid, and standing;

(b) and wiping the standing medical mirror surface by using a dry carrier, so that an antifogging film is formed on the surface of the medical mirror surface.

preferably, in the step (a), the weight gain rate of the carrier is 137-178%;

preferably, in step (a), the wet film thickness is from 8 to 15 μm;

preferably, in step (a), the standing time is 3-5 min.

The invention also provides a medical appliance, wherein the medical mirror surface of the medical appliance is obtained by carrying out anti-fog treatment on the medical mirror surface anti-fog liquid, the medical mirror surface anti-fog film or the anti-fog method;

preferably, the medical device comprises any one of an endoscope, radiation protection spectacles, laryngoscope or an oral scope.

Compared with the prior art, the medical mirror surface antifogging liquid and the preparation method thereof, the medical mirror surface antifogging film and the preparation method thereof, the antifogging method and the medical apparatus provided by the invention have the following advantages:

(1) the invention provides a medical mirror surface antifogging fluid which is prepared from an active agent, a slow release agent, a toughening agent and water with specific dosage, wherein a biological refining agent of a specific type and ethanol are compounded to serve as the toughening agent, and polyhydric alcohol serves as the slow release agent and is in synergistic effect with other components such as the active agent; meanwhile, various raw materials of the medical mirror antifogging fluid are easy to obtain, the production cost is low, and the popularization and the application are facilitated.

(2) The invention provides a preparation method of the medical mirror antifogging fluid, which is simple and convenient to operate and suitable for industrial mass production.

(3) The invention provides a medical mirror surface anti-fog film which is mainly prepared from the medical mirror surface anti-fog liquid. In view of the advantages of the medical mirror surface antifogging liquid, the medical mirror surface antifogging film formed by the medical mirror surface antifogging liquid has good toughness and light transmission, has lasting antifogging effect, and can meet the requirements of most clinical operations.

(4) The invention provides a preparation method of a medical mirror anti-fog film, which is simple and easy to operate and enables the medical mirror anti-fog film to be easily obtained.

(5) The invention provides an anti-fog method which is simple and easy to operate, and the medical mirror surface anti-fog liquid can be used for carrying out anti-fog treatment on the medical mirror surface easily and has good anti-fog effect.

(6) The invention provides a medical appliance, and the medical mirror surface of the medical appliance is obtained by carrying out anti-fog treatment on the medical mirror surface anti-fog liquid, the medical mirror surface anti-fog film or the anti-fog method. In view of the advantages of the medical mirror surface antifogging liquid, the medical mirror surface antifogging film or the antifogging method, the antifogging effect of the medical mirror surface of the medical instrument is good, so that the medical instrument has a clear visual field in the operation process, a doctor can know the focus condition accurately, and the smooth operation is facilitated.

Detailed Description

The technical solutions of the present invention will be described clearly and completely with reference to the following embodiments, and it should be understood that the described embodiments are some, but not all, embodiments of the present invention. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.

According to a first aspect of the invention, the medical mirror antifogging fluid comprises the following components in percentage by weight: 3-15% of active agent, 10-35% of slow release agent, 2-20% of toughening agent and 40-85% of water;

the sustained release agent comprises a polyhydric alcohol;

the toughening agent comprises a biological refining agent and ethanol, and the biological refining agent comprises any one or a combination of at least two of hyaluronate, chitosan or elastin peptide.

Specifically, the action of the active agent is mainly used for changing molecular kinetic energy and stress relation on gas-liquid phase and liquid-solid phase interfaces, so that water molecules forming fog spread on a mirror surface and change from a non-wetting state to a wetting state, and the formation of the fog is prevented. Hyaluronate, chitosan or elastin peptide can achieve the above functions.

Typical but non-limiting weight percentages of active agent are 3%, 4%, 5%, 6%, 7%, 8%, 9%, 10%, 11%, 12%, 13%, 14% or 15%.

There are many kinds of active agents, for example, any one or a combination of at least two of a sulfonic acid type anionic surfactant, a benzenesulfonic acid type anionic surfactant, a polyether-modified silicone surfactant, and a polyoxyethylene type nonionic surfactant can be used as an active agent in a medical mirror antifogging liquid for preventing the formation of mist.

The slow release agent has good moisture absorption performance, can increase the lubricity of the medical mirror and the viscosity of the active agent, and can prevent the generation of scale. The slow release agent comprises polyalcohol, wherein the polyalcohol refers to alcohol containing two or more hydroxyl groups in molecules.

The sustained release agent is typically, but not limited to, 10%, 12%, 14%, 15%, 16%, 18%, 19%, 20%, 22%, 24%, 25%, 26%, 28%, 30%, 32%, 34%, or 35% by weight.

The toughening agent is mainly used for enhancing the toughness of a film layer of the medical mirror surface antifogging liquid when an antifogging film is formed on a mirror surface. In the invention, the toughening agent is compounded by adopting a specific type of biological refining agent and ethanol, so that the toughness and the adsorption force of the antifogging film are increased while the rapid film forming of the medical mirror surface antifogging liquid is ensured.

If the biological refining agent is not added into the medical mirror surface antifogging liquid, when the antifogging wet tissue soaked with the medical mirror surface antifogging liquid is used for wiping a smooth medical mirror surface, particularly the contact is carried out in a flat and fitting state, the active agent is difficult to stay on the mirror surface for enough film forming quantity, and the less the film forming quantity is, the thinner the film is, the poorer the durability of the antifogging film is; and with the addition of the biological refining agent, the interaction parameters among molecules of the hydrophobic group adsorption layer in the active agent are increased, the attraction is enhanced, the film forming speed is improved, the durability of the anti-fog film is improved, and the anti-fog time is effectively prolonged.

Typical but non-limiting weight percentages of tougheners are 2%, 3%, 4%, 5%, 6%, 7%, 8%, 9%, 10%, 11%, 12%, 13%, 14%, 15%, 16%, 18%, 19%, or 20%.

Water is typically, but not limited to, 40%, 42%, 44%, 45%, 46%, 48%, 50%, 52%, 54%, 55%, 56%, 58%, 60%, 62%, 64%, 65%, 66%, 68%, 70%, 72%, 74%, 75%, 76%, 78%, 80%, 82%, 84%, or 85% by weight.

In order to quickly form an antifogging film on a medical mirror surface, continuously and sufficiently complete an antifogging effect within a clinical operation time, not damage the medical mirror surface, easy cleaning, difficult residue and guarantee that the medical mirror surface is not influenced by subsequent repeated use, the invention provides a medical mirror surface antifogging liquid from fluid mechanics, the medical mirror surface antifogging liquid is prepared from an active agent, a slow release agent, a toughening agent and water with specific dosage, wherein a biological refining agent and ethanol are compounded to serve as the toughening agent, and polyhydric alcohol serves as the slow release agent and is in synergistic effect with the active agent, the water and other components. The active agent with proper concentration can change the kinetic energy of water molecules on the mirror surface, prevent the formation of small water drops, ensure that the medical mirror surface can not generate refraction, diffusion and reflection, and realize the anti-fog function, but under the condition of larger temperature and humidity difference existing in an operating room and a patient body, the anti-fog effect lasting for several hours is difficult to realize by only adopting the active agent, so that on one hand, a proper amount of slow-release agent is adopted to continuously enable the active agent to release the kinetic energy, on the other hand, a proper amount of substance with better film forming property is adopted to increase the viscosity of the active agent, and in addition, water can drive active agent molecules to be vertically arranged to form an interface film, so that the energy of the active agent tends to be. Therefore, a certain synergistic effect exists among the active agent, the slow release agent, the toughening agent, the water and other components.

Moreover, the weight percentages of the active agent, the slow release agent, the toughening agent and the water are limited to a certain extent, for example, when the weight percentage of the active agent is less than 3%, a contact angle is larger, water molecules cannot move towards a water film direction, and water drops are formed, so that the anti-fog failure is caused, and when the weight percentage of the active agent is more than 15%, the internal energy of the active agent is counteracted, the self-consumption is increased, the molecular kinetic energy is insufficient, and the anti-fog function is difficult to realize; when the weight percentage of the slow release agent is lower than 10%, the antifogging effect can be realized in a short time, and the continuous antifogging effect cannot be achieved, and when the weight percentage of the slow release agent is higher than 35%, the energy of the active agent can be covered, so that the antifogging effect is easier to fog compared with the antifogging liquid without the medical mirror surface; when the weight percentage of the toughening agent is lower than 2%, the quantity of the active agent staying on the medical mirror surface is less, so that the anti-fog effect is poor, and when the weight percentage of the toughening agent is higher than 20%, the medical mirror surface generates halation to influence the quality of the mirror image; when the weight percentage of water is less than 40%, the active agent cannot break the intrinsic molecular bond and a film layer cannot be formed efficiently, and when the weight percentage of water is more than 85%, the molecular energy is insufficient and the antifogging effect is lost in a short time. It follows that the weight percentages of the components should be kept within the specified numerical ranges.

The medical mirror surface antifogging fluid prepared from the active agent, the slow release agent, the toughening agent, the water and the like with the specific dosage has no stimulation effect on a human body and has excellent antifogging effect and lasting time, and an antifogging film formed on the medical mirror surface has good toughness and light transmittance and can meet the requirements of most clinical operations. Meanwhile, various raw materials of the medical mirror antifogging fluid are easy to obtain, the production cost is low, and the popularization and the application are facilitated.

The term "comprising" as used herein means that it may include other components in addition to the components described, which impart different properties to the medical mirror antifogging fluid. In addition, the term "comprising" as used herein may be replaced by "being" or "made from … …" as closed.

As an optional implementation mode of the invention, the medical mirror antifogging fluid comprises the following components in percentage by weight: 3.5 to 14.9 percent of active agent, 11 to 34 percent of slow release agent, 3 to 16 percent of toughening agent and 45 to 80 percent of water;

By further limiting the dosage of various raw materials of the medical mirror surface antifogging liquid, the antifogging effect and the lasting time of the medical mirror surface antifogging liquid are better.

As an optional embodiment of the invention, the mass ratio of the biological refining agent to the ethanol in the toughening agent is (0.05-5): (1-35); typical but non-limiting mass ratios of biorefinents to ethanol are 0.05:1, 0.05:10, 0.05:20, 0.05:30, 0.05:35, 0.1:1, 0.1:10, 0.1:20, 0.1:30, 0.1:35, 1:1, 1:10, 1:20, 1:30, 1:35, 2:1, 2:10, 2:20, 2:30, 2:35, 3:1, 3:10, 3:20, 3:30, 3:35, 4:1, 4:10, 4:20, 4:30, 4:35, 5:1, 5:10, 5:20, 5:30, or 5: 35.

The mass ratio of the biological refining agent to the ethanol in the toughening agent is further limited, so that the toughening agent has a better toughening effect in the medical mirror surface antifogging fluid.

As an alternative embodiment of the invention, the biorefinery is a hyaluronate, preferably the hyaluronate comprises sodium hyaluronate.

Through further limiting the specific types of the biological extracting agent and the hyaluronic acid salt in the toughening agent, the compounding effect between the biological extracting agent and the ethanol is better, and the toughness of the antifogging film formed by the medical mirror antifogging liquid on the medical mirror is further improved.

As an alternative embodiment of the present invention, the active agent includes any one or a combination of at least two of sodium dodecyl benzene sulfonate, sodium hexadecyl sulfonate, sodium diisooctyl succinate sulfonate, polydimethylsiloxane, methyl hydrogen silicone oil, methyl vinyl silicone oil, fatty alcohol polyoxyethylene ether or alkylphenol polyoxyethylene ether.

As an optional embodiment of the invention, the active agent comprises sodium dodecyl benzene sulfonate, polydimethylsiloxane and alkylphenol polyoxyethylene ether, and the mass ratio of the sodium dodecyl benzene sulfonate to the polydimethylsiloxane to the alkylphenol polyoxyethylene ether is (0.5-10): (1-15): (0.1-5).

Typical but not limiting mass ratios of sodium dodecylbenzenesulfonate, polydimethylsiloxane, and alkylphenol ethoxylates are 0.5:1:0.1, 0.5:3:0.1, 0.5:5:0.1, 0.5:8:0.1, 0.5:10:0.1, 0.5:12:0.1, 0.5:15:0.1, 2:1:0.1, 2:3:0.1, 2:5:0.1, 2:8:0.1, 2:10:0.1, 2:12:0.1, 2:15:0.1, 5:1:0.1, 5:3:0.1, 5:5:0.1, 5:8:0.1, 5:10:0.1, 5:12:0.1, 5:15:0.1, 8:1:0.1, 8:3:0.1, 8:1: 8:0.1, 5:8:0.1, 1: 10:0.1, 5:10:0.1, 0.1: 8:1: 8:0.1, 0.8: 1: 8:0.1, 0.8: 1:1, 0.8: 0.1: 1:1, 0.8: 1: 0.8: 1:0.1, 0.8: 1: 0.8: 0.1, 0.8: 1: 0.8: 1 0.5:8:5, 5:3:1, 5:5:2, 5:8:5, 10:5:1, 10:8:2, 10:10:4, 10:12:5, or 10:15: 5.

The sodium dodecyl benzene sulfonate, the polydimethylsiloxane and the alkylphenol polyoxyethylene ether have different charge characteristics and mutually attracted alkane isomer groups, and after being compounded, the three substances have good stability, are non-toxic and harmless to human bodies and cannot stimulate the human bodies.

As an alternative embodiment of the present invention, the sustained release agent includes any one or a combination of at least two of glycerol, ethylene glycol, butylene glycol, isopropyl alcohol, propylene glycol, or polyvinyl alcohol;

preferably, the sustained release agent comprises glycerol and ethylene glycol, wherein the mass ratio of the glycerol to the ethylene glycol is (1-15): (2-30); typical but non-limiting mass ratios of glycerol and ethylene glycol are 1:2, 1:5, 1:8, 1:10, 1:15, 1:18, 1:20, 1:25, 1:30, 5:2, 5:5, 5:8, 5:10, 5:15, 5:18, 5:20, 5:25, 5:30, 10:2, 10:5, 10:8, 10:10, 10:15, 10:18, 10:20, 10:25, 10:30, 15:2, 15:5, 15:8, 15:10, 15:15, 15:18, 15:20, 15:25, or 15: 30.

The slow release agent is mainly added for prolonging the antifogging aging of the active agent, on one hand, the slow release effect of the selected propionic acid alcohol is better in consideration that most of sulfonic acid anionic or benzenesulfonic acid anionic surfactants are organic acid salts, the pH value of the sulfonic acid anionic or benzenesulfonic acid anionic surfactants is more than 7, the activity is high, the activity is low below the pH value of 4, and the clarity of a mirror surface is influenced due to the fact that the polyether modified organic silicon surface active agent or polyoxyethylene type nonionic surfactant generates turbidity when being heated. On the other hand, the ethylene glycol which is more stable in compatibility with the ethylene glycol is selected as a compound in consideration of the fact that the ethylene glycol can adsorb surrounding wet air due to long time or large dosage, so that the aim of continuously preventing fog is fulfilled, and the effect of the active agent is promoted to be enhanced without influencing the transmission of mirror images.

In an alternative embodiment of the present invention, the ethanol may be an ethanol solution with a volume fraction of 95% or more, or may be absolute ethanol.

As an alternative embodiment of the invention, the water is purified water.

The purified water is water for medical use prepared by distillation, ion exchange, reverse osmosis or other suitable method, and does not contain any additive.

Purified water tends to increase the energy of the active agent, concentrating on the surface layer, which is required for the function of the medical mirror antifogging fluid. The 'amphiphilic' structure bridge function of the active agent is fully exerted, and the work required by the interface of unit area is reduced. According to the principle of 'similar phase affinity', when the molecules of the active agent enter the aqueous solution and reach a certain value, the active agent is basically vertically and tightly arranged to form an interfacial film, so that the surface tension of a substance generating fog is reduced, a water film is formed, water drops are not formed, and diffuse reflection, reflection and refraction are avoided. Therefore, the purified water can greatly promote the antifogging function of the medical mirror liquid.

According to a second aspect of the present invention, there is provided a method for preparing the medical mirror antifogging fluid, comprising the steps of:

mixing the active agent, the slow release agent, the toughening agent and water in proportion to obtain the medical mirror surface antifogging solution.

The invention provides a preparation method of the medical mirror antifogging fluid, which is simple and convenient to operate and suitable for industrial mass production.

As an optional embodiment of the invention, the mixing is accompanied by stirring, the stirring speed is 15-50r/s, and the stirring time is 10-60 min;

typical but not limiting agitation speeds are 15r/s, 20r/s, 25r/s, 30r/s, 35r/s, 40r/s, 45r/s or 50r/s, and typical but not limiting agitation times are 10min, 12min, 15min, 18min, 20min, 30min, 35min, 38min, 40min, 42min, 45min, 48min, 50min, 52min, 55min, 58min or 60 min.

As an alternative embodiment of the invention, the step of mixing further comprises a step of standing.

Preferably, the standing time is 1-24 h. Typical but non-limiting standing times are 1h, 2h, 4h, 5h, 8h, 10h, 12h, 15h, 16h, 18h, 20h, 22h or 24 h.

According to a third aspect of the invention, the invention further provides a medical mirror antifogging film, which is prepared from the medical mirror antifogging liquid or the medical mirror antifogging liquid prepared by the preparation method of the medical mirror antifogging liquid.

In view of the advantages of the medical mirror surface antifogging liquid, the medical mirror surface antifogging film formed by the medical mirror surface antifogging liquid has good toughness and light transmission, has lasting antifogging effect, and can meet the requirements of most clinical operations.

According to a fourth aspect of the present invention, there is provided a method for preparing the medical mirror antifogging film, comprising the steps of:

Specifically, in the step (a), the wet carrier wetted by the medical mirror surface antifogging liquid contains a certain amount of medical mirror surface antifogging liquid, when the wet carrier is wiped on the medical mirror surface to be subjected to antifogging treatment, the medical mirror surface antifogging liquid forms a liquid film on the medical mirror surface, and then the medical mirror surface is kept still, so that the liquid film reaches a certain thickness.

In the step (b), the medical mirror surface after standing is wiped by a dry carrier. After the wet carrier is used for wiping the medical mirror surface in the step (a), the medical mirror surface antifogging liquid forms a film on the medical mirror surface, and after a certain film forming time, the medical mirror surface after standing is wiped by the dry carrier, so that redundant medical mirror surface antifogging liquid which does not form a film on the medical mirror surface is wiped off, otherwise, the redundant medical mirror surface antifogging liquid exists on the medical mirror surface in a liquid bead form, and the observation in the operation is influenced.

The preparation method of the medical mirror surface anti-fog film provided by the invention is simple and easy to operate, and the medical mirror surface anti-fog film is easy to obtain.

As an alternative embodiment of the present invention, in the step (a), the wet carrier wetted by the medical mirror antifogging fluid is prepared by the following steps:

and soaking the carrier in the medical mirror surface antifogging liquid, and fully wetting to ensure that the weight gain rate of the carrier is 120-180%, thereby obtaining the wet carrier wetted by the medical mirror surface antifogging liquid.

The carrier is soaked in the medical mirror surface antifogging liquid, so that a certain amount of medical mirror surface antifogging liquid is contained in the carrier. The degree of thorough wetting (impregnation) was such that the weight gain of the support was 120-180%.

Typical, but non-limiting, carriers have a rate of weight gain of 120%, 125%, 130%, 135%, 140%, 145%, 150%, 155%, 160%, 165%, 170%, 175%, or 180%. The wet carrier contains a certain amount of medical mirror antifogging fluid through the limitation of the weight gain rate of the fully wetted carrier. If the weight gain of the wetted carrier is less than 120%, the film is difficult to form on the medical mirror surface or the thickness of the formed liquid film is thin, thereby affecting the effect of wiping the subsequent dry carrier to form the film. If the weight gain rate of the wetted carrier is higher than 180%, the thickness of a liquid film formed on the medical mirror surface is thicker, and a halo is easily formed when the carrier is subsequently wiped by a dry carrier.

and soaking the carrier in the medical mirror antifogging liquid, fully wetting, taking out and extruding to the extent that the weight gain rate of the carrier is 180%, and obtaining the wet carrier wetted by the medical mirror antifogging liquid.

As an alternative embodiment of the present invention, in step (a), the weight gain of the carrier is 137-178%.

The medical mirror surface antifogging liquid forms a medical mirror surface antifogging film with proper thickness on the medical mirror surface through further limiting the weight gain rate of the wetted carrier.

As an alternative embodiment of the present invention, in step (a), the wet film thickness is from 8 to 15 μm.

The wet film thickness refers to the thickness of a film layer on the surface of the medical mirror surface after the medical mirror surface to be subjected to antifogging treatment is wiped by using a wet carrier. Typical but non-limiting wet films have a thickness of 8 μm, 9 μm, 10 μm, 11 μm, 12 μm, 13 μm, 14 μm or 15 μm.

As an alternative embodiment of the present invention, in step (a), the standing time is 3 to 5 min. Typical but non-limiting standing times are 3min, 3.5min, 4min, 4.5min or 5 min. If the time interval is too long and exceeds 5min, preoperative preparation time is affected, and clinical application is not facilitated; if the time interval is too short and less than 3min, the film forming effect is affected, and the anti-fog effect is further affected.

According to a fifth aspect of the present invention, there is also provided an anti-fogging method for performing anti-fogging treatment on a medical mirror surface by using the medical mirror surface anti-fogging liquid, comprising the following steps:

The anti-fog method is simple and easy to operate, and the medical mirror surface anti-fog liquid can be used for performing anti-fog treatment on the medical mirror surface easily and has a good anti-fog effect.

As an alternative embodiment of the present invention, in step (a), the wet film thickness is from 8 to 15 μm; typical but non-limiting wet films have a thickness of 8 μm, 9 μm, 10 μm, 11 μm, 12 μm, 13 μm, 14 μm or 15 μm.

As an alternative embodiment of the present invention, in the step (a), the carrier is selected from any one of a fine fiber knitted fabric, a blended spunlace nonwoven fabric or a water-resistant paper.

In an alternative embodiment of the present invention, in step (b), the dry carrier comprises a tissue-type lens-wiping paper.

By limiting the types of the carrier and the dry carrier, the medical mirror surface antifogging liquid can quickly form a film on the surface of the medical mirror surface, the interval time between wet wiping and dry wiping is reduced to 3-5min, and the operation preparation time of medical personnel is effectively shortened.

According to the fifth aspect of the invention, a medical instrument is also provided, and the medical mirror surface of the medical instrument is obtained by performing anti-fog treatment by using the medical mirror surface anti-fog liquid, the medical mirror surface anti-fog film or the anti-fog method.

In view of the advantages of the medical mirror surface antifogging liquid, the medical mirror surface antifogging film or the antifogging method, the antifogging effect of the medical mirror surface of the medical instrument is good, so that the medical instrument has a clear visual field in the operation process, a doctor can know the focus condition accurately, and the smooth operation is facilitated.

The specific type of medical device is not limited. As an alternative embodiment of the invention, the medical device comprises any one of an endoscope, radiation protection spectacles, a laryngoscope or an oral scope.

In order to facilitate understanding of the present invention, the present invention will be further described below with reference to specific examples and comparative examples. Wherein the chitosan is water-soluble chitosan, and is available from Shandong Ookang Biotechnology GmbH; the elastin peptide is purchased from the manufacturer of Xian Precisi bioengineering, Inc., and the type is 99% elastin peptide.

Example 1

The embodiment provides medical mirror antifogging fluid which comprises the following components in percentage by weight:

3.59 percent of active agent, 28.01 percent of slow release agent, 15.07 percent of toughening agent and 53.23 percent of purified water;

wherein the active agent comprises sodium dodecyl benzene sulfonate, polydimethylsiloxane and alkylphenol polyoxyethylene ether, and the weight ratio of the sodium dodecyl benzene sulfonate to the polydimethylsiloxane to the alkylphenol polyoxyethylene ether is 1.09:1.5: 1;

the sustained release agent comprises glycol and glycerol, wherein the weight ratio of the glycol to the glycerol is 14.01: 14;

the toughening agent comprises anhydrous ethanol and sodium hyaluronate, and the weight ratio of the anhydrous ethanol to the sodium hyaluronate is 15: 0.17.

Through detection, the pH value of the medical mirror antifogging fluid is 8.36.

Example 2

3.67 percent of active agent, 14.2 percent of slow release agent, 2.74 percent of toughening agent and 79.39 percent of purified water;

wherein the active agent comprises sodium dodecyl benzene sulfonate, polydimethylsiloxane and alkylphenol polyoxyethylene ether, and the weight ratio of the sodium dodecyl benzene sulfonate to the polydimethylsiloxane to the alkylphenol polyoxyethylene ether is 1.07:1.6: 1;

the sustained release agent comprises glycol and glycerol, wherein the weight ratio of the glycol to the glycerol is 7.2: 7;

the toughening agent comprises anhydrous ethanol and sodium hyaluronate, and the weight ratio of the anhydrous ethanol to the sodium hyaluronate is 2: 0.74.

The pH value of the medical mirror antifogging fluid is 10.69 through detection.

Example 3

14.8 percent of active agent, 26.54 percent of slow release agent, 11.37 percent of toughening agent and 47.29 percent of purified water;

wherein the active agent comprises sodium dodecyl benzene sulfonate, polydimethylsiloxane and alkylphenol polyoxyethylene ether, and the weight ratio of the sodium dodecyl benzene sulfonate to the polydimethylsiloxane to the alkylphenol polyoxyethylene ether is 4.4:7.4: 3;

the sustained release agent comprises ethylene glycol and glycerol, wherein the weight ratio of the ethylene glycol to the glycerol is 13.5: 13.04;

the toughening agent comprises anhydrous ethanol and sodium hyaluronate, and the weight ratio of the anhydrous ethanol to the sodium hyaluronate is 10: 1.37.

The pH value of the medical mirror antifogging fluid is 10.96 through detection.

Example 4

6.82 percent of active agent, 31.11 percent of slow release agent, 8.23 percent of toughening agent and 53.84 percent of purified water;

wherein the active agent comprises sodium dodecyl benzene sulfonate, polydimethylsiloxane and alkylphenol polyoxyethylene ether, and the weight ratio of the sodium dodecyl benzene sulfonate to the polydimethylsiloxane to the alkylphenol polyoxyethylene ether is 2:3.42: 1.4;

the sustained release agent comprises ethylene glycol and glycerol, wherein the weight ratio of the ethylene glycol to the glycerol is 16.11: 15;

the toughening agent comprises anhydrous ethanol and sodium hyaluronate, and the weight ratio of the anhydrous ethanol to the sodium hyaluronate is 4.88: 3.35.

The pH value of the medical mirror antifogging fluid is 10.87 through detection.

Example 5

The embodiment provides a medical mirror antifogging fluid, except that an active agent in the medical mirror antifogging fluid, including sodium dodecyl benzene sulfonate, polydimethylsiloxane and alkylphenol ethoxylates, is replaced by sodium dodecyl benzene sulfonate, the dosage of the sodium dodecyl benzene sulfonate is 14.8%, and the other raw materials and dosages are the same as those in embodiment 3.

Through detection, the pH value of the medical mirror antifogging fluid is 8.81.

Example 6

The embodiment provides a medical mirror antifogging fluid, except that the active agents in the medical mirror antifogging fluid, including sodium dodecyl benzene sulfonate, polydimethylsiloxane and alkylphenol ethoxylates, are replaced by polydimethylsiloxane, the dosage of the polydimethylsiloxane is still 14.8%, and the other raw materials and the dosages are the same as those in embodiment 3.

The pH value of the medical mirror antifogging fluid is 4.72 through detection.

Example 7

The embodiment provides a medical mirror antifogging fluid, except that the sustained-release agent in the medical mirror antifogging fluid, including glycerol and ethylene glycol, is replaced by glycerol, the amount of glycerol is 26.54%, and the other raw materials and the amounts are the same as those in embodiment 3.

Through detection, the pH value of the medical mirror antifogging fluid is 11.59.

The preparation method of the medical mirror antifogging fluid provided in embodiments 1 to 7 includes the following steps:

mixing the active agent, the sustained-release agent, the toughening agent and water in proportion, stirring at the stirring speed of 25r/s for 30min while stirring, and standing for 10h after mixing to obtain the medical mirror antifogging solution.

Example 8

wherein the active agent comprises sodium dodecyl benzene sulfonate and polydimethylsiloxane, and the weight ratio of the sodium dodecyl benzene sulfonate to the polydimethylsiloxane is 7.4: 7.4;

the slow release agent is glycol;

the toughening agent comprises absolute ethyl alcohol and chitosan, and the weight ratio of the absolute ethyl alcohol to the sodium hyaluronate is 10: 1.37.

Through detection, the pH value of the medical mirror antifogging fluid is 12.24.

The preparation method of the medical mirror antifogging fluid provided in embodiment 8 includes the following steps:

mixing the active agent, the sustained-release agent, the toughening agent and water in proportion, stirring at the stirring speed of 30r/s for 25min while stirring, and standing for 8h after mixing to obtain the medical mirror antifogging solution.

Example 9

wherein the active agent comprises sodium hexadecyl sulfonate and polydimethylsiloxane, and the weight ratio of the sodium dodecyl benzene sulfonate to the polydimethylsiloxane is 7.4: 7.4;

the sustained release agent is glycerol and glycol, and the mass ratio of the glycerol to the glycol is 10: 16.54 of;

the toughening agent comprises ethanol and elastin peptide, and the weight ratio of the ethanol to the elastin peptide is 10: 1.37.

The pH value of the medical mirror antifogging fluid is 4.33 through detection.

The preparation method of the medical mirror antifogging fluid provided by the embodiment is the same as that of the embodiment 8.

Examples 10 to 18

Examples 10 to 18 respectively provide a medical mirror antifogging film, which is respectively prepared by using the medical mirror antifogging liquids described in examples 1 to 9;

the method for preparing the medical mirror antifogging film provided in embodiments 10 to 18 includes the steps of:

(a) soaking a carrier fine fiber knitted fabric in the medical mirror surface antifogging liquid, and fully wetting to ensure that the weight gain rate of the carrier is 140 percent to obtain a wet carrier wetted by the medical mirror surface antifogging liquid;

wiping the wet carrier wetted by the medical mirror surface antifogging liquid on the medical mirror surface to be subjected to antifogging treatment, and then standing the medical mirror surface for 4 min;

(b) and wiping the medical mirror surface after standing by adopting dry carrier tissue paper lens wiping paper to obtain the medical mirror surface antifogging film.

Example 19

The embodiment provides a medical mirror antifogging film, which is prepared by adopting the medical mirror antifogging liquid described in the embodiment 3;

the preparation method of the medical mirror antifogging film provided in this example is the same as examples 10 to 18 except that the weight gain ratio of the carrier in step (a) is replaced by 120%, and the remaining steps and process parameters are the same as those in examples 10 to 18.

Example 20

the preparation method of the medical mirror antifogging film provided in this example is the same as examples 10 to 18 except that the weight gain ratio of the carrier in step (a) is replaced by 180%, and the remaining steps and process parameters are the same as those in examples 10 to 18.

Example 21

the preparation method of the medical mirror antifogging film provided in this example is the same as examples 10 to 18 except that the standing time in step (a) is replaced by the standing time of 2min, and the rest steps and process parameters are the same as those in examples 10 to 18.

Example 22

the preparation method of the medical mirror antifogging film provided in this example is the same as examples 10 to 18 except that the standing time in step (a) is replaced by 4min, and the standing time is replaced by 5 min.

Comparative example 1

The comparative example provides a medical mirror antifogging fluid, which comprises the following components in percentage by weight:

25% of active agent, 68.75% of slow release agent and 6.25% of toughening agent;

wherein the active agent comprises sodium dodecyl benzene sulfonate, polydimethylsiloxane and alkylphenol polyoxyethylene ether, and the weight ratio of the sodium dodecyl benzene sulfonate to the polydimethylsiloxane to the alkylphenol polyoxyethylene ether is 7:13: 5;

the sustained release agent comprises ethylene glycol and glycerol, wherein the weight ratio of the ethylene glycol to the glycerol is 34.7: 34.05;

the toughening agent is absolute ethyl alcohol.

The pH value of the medical mirror antifogging fluid is 11.24 through detection.

Comparative example 2

4.55% of active agent, 14.36% of slow release agent, 4.88% of toughening agent and 76.21% of purified water;

wherein the active agent comprises sodium dodecyl benzene sulfonate, polydimethylsiloxane and alkylphenol polyoxyethylene ether, and the weight ratio of the sodium dodecyl benzene sulfonate to the polydimethylsiloxane to the alkylphenol polyoxyethylene ether is 1.15:2.4: 1;

the sustained release agent comprises glycol and glycerol, wherein the weight ratio of the glycol to the glycerol is 7.36: 7;

the toughening agent is absolute ethyl alcohol.

Through detection, the pH value of the medical mirror antifogging fluid is 10.4.

Comparative example 3

The comparative example provides a medical mirror antifogging fluid, except that the toughening agents including absolute ethyl alcohol and sodium hyaluronate in the medical mirror antifogging fluid are replaced by the toughening agents of the absolute ethyl alcohol, the weight fraction of the absolute ethyl alcohol is 11.37%, and the rest raw materials and the using amount are the same as those in example 3.

The pH value of the medical mirror antifogging fluid is 11.81 through detection.

Comparative example 4

The comparative example provides a medical mirror antifogging fluid, except that the toughening agents including absolute ethyl alcohol and sodium hyaluronate are replaced by sodium hyaluronate, the weight fraction of the sodium hyaluronate is 11.37%, and the rest raw materials and the using amount are the same as those in example 3.

The pH value of the medical mirror antifogging fluid is 11.20 through detection.

Comparative example 5

The comparative example provides a medical mirror antifogging fluid, except that the toughening agents including absolute ethyl alcohol and sodium hyaluronate in the medical mirror antifogging fluid are replaced by the toughening agents of the absolute ethyl alcohol, the weight fraction of the absolute ethyl alcohol is 8.23%, and the rest raw materials and the using amount are the same as those in example 4.

The pH value of the medical mirror antifogging fluid is 11.36 through detection.

Comparative example 6

The comparative example provides a medical mirror antifogging fluid, except that the toughening agents including absolute ethyl alcohol and sodium hyaluronate are replaced by sodium hyaluronate, the weight fraction of the sodium hyaluronate is 8.23%, and the rest raw materials and the using amount are the same as those in example 4.

The pH value of the medical mirror antifogging fluid is 11.09 through detection.

Comparative example 7

The comparative example provides a medical mirror antifogging fluid, except that the toughening agent in the raw material of the medical mirror antifogging fluid in the example 4 is removed, and the rest raw materials are added in equal proportion until the total dosage of the active agent, the slow release agent and the purified water reaches 100%.

Comparative example 8

The comparative example provides a medical mirror antifogging fluid, except that purified water in the raw material of the medical mirror antifogging fluid in the example 4 is removed, and the rest raw materials are proportionally increased to the total dosage of the active agent, the slow release agent and the toughening agent to 100 percent.

The pH value of the medical mirror antifogging fluid is 11.76 through detection.

Comparative example 9

18% of active agent, 8% of slow release agent, 22.5% of toughening agent and 51.5% of purified water;

the active agent comprises sodium dodecyl benzene sulfonate, polydimethylsiloxane and alkylphenol polyoxyethylene ether, and the weight ratio of the sodium dodecyl benzene sulfonate to the polydimethylsiloxane to the alkylphenol polyoxyethylene ether is 1:1: 3;

the sustained release agent comprises glycol and glycerol, wherein the weight ratio of the glycol to the glycerol is 3.5: 4.5;

the toughening agent comprises anhydrous ethanol and sodium hyaluronate, and the weight ratio of the anhydrous ethanol to the sodium hyaluronate is 12: 10.5.

The pH value of the medical mirror antifogging fluid is 12.36 through detection.

Comparative example 10

2% of active agent, 40% of slow release agent, 1.8% of toughening agent and 56.2% of purified water;

wherein the active agent comprises sodium dodecyl benzene sulfonate, polydimethylsiloxane and alkylphenol polyoxyethylene ether, and the weight ratio of the sodium dodecyl benzene sulfonate, the polydimethylsiloxane and the alkylphenol polyoxyethylene ether is 1:0.5: 0.5;

the sustained release agent comprises glycol and glycerol, wherein the weight ratio of the glycol to the glycerol is 17.5: 22.5;

the toughening agent comprises anhydrous ethanol and sodium hyaluronate, and the weight ratio of the anhydrous ethanol to the sodium hyaluronate is 1.2: 0.6.

The pH value of the medical mirror antifogging fluid is 10.83 through detection.

The preparation methods of the medical mirror antifogging solutions provided in comparative examples 1 to 10 are the same as those of the medical mirror antifogging solutions provided in examples 1 to 9, and are not described herein again.

Comparative examples 11 to 20

Comparative examples 11 to 20 respectively provide a medical mirror antifogging film, which was prepared using the medical mirror antifogging liquids described in comparative examples 1 to 10, respectively;

the production methods of the medical mirror antifogging films provided in comparative examples 11 to 20 were the same as those of the medical mirror antifogging films provided in examples 10 to 18.

Comparative example 21

The comparative example provides a medical mirror antifogging film prepared by using the medical mirror antifogging fluid described in example 3;

the comparative example provides a method for producing a medical mirror antifogging film, which comprises the same steps and process parameters as in examples 10 to 18, except that the step of standing in the step (a) is eliminated.

In order to verify the technical effects of the respective examples and comparative examples, the following experimental examples were specifically set.

Experimental example 1

The medical mirror antifogging liquids provided in examples 1 to 9 and comparative examples 1 to 10 were subjected to a long-time antifogging effect test under conditions of simulating the ambient temperature of the operating room, the relative humidity, the temperature before use of the device, and the temperature during use of the device. Wherein the test environment temperature is 25 ℃ and the relative humidity is 45-65%.

The test procedure was as follows:

(1) setting the temperature of the water bath kettle to be 37.5 ℃, and starting the water bath kettle;

(2) soaking the dry wiping mirror cloth in the medical mirror surface antifogging liquid provided by each embodiment or comparative example, and fully wetting to ensure that the weight gain rate of the carrier is 140 percent to obtain wet wiping mirror cloth;

placing the non-frosted surface of the glass slide to be tested for more than 1.5h in a test environment, wiping the half of the non-frosted end of the glass slide close to the outer side by using wet wiping mirror cloth, and wiping the glass slide dry by using dry wiping mirror cloth after 4min interval;

(3) moving the dried glass slide to the position above an observation hole of a water bath kettle immediately, so that water vapor is sprayed on the surface of the glass slide, which is coated with the medical mirror surface antifogging liquid and forms an antifogging film, and observing whether the glass slide is fogged or not and whether a mark point can still be clearly observed or not, wherein the mark point is a 30cm visual chart used by a hospital behind the glass slide;

(4) repeating the step (3) every 15min, determining the time point when the fogging condition of the glass slide is changed from obvious non-fogging to non-fogging judgment on whether fogging exists as non-fogging duration, judging whether the mirror surface is fogged or not at the moment, reducing the observation definition of the mark point and still accurately identifying the mark point; determining the time point of the glass slide from the condition that whether the glass slide is fogged or not to the condition that the glass slide is obviously fogged and the observation and conversion of the mark point are influenced as the 'starting fogging time', wherein the condition that the glass slide starts to be fogged and the mark point cannot be clearly observed can be observed at the moment;

(5) adjusting the temperature of the water bath kettle to 45 ℃ for later use;

(6) and (5) repeating the steps (2) to (4), and recording the antifogging effect of the antifogging film formed on the glass slide by the medical mirror surface antifogging liquid.

Specific results are shown in table 1.

TABLE 1

As can be seen from the data in Table 1, the antifogging performance of the medical mirror antifogging fluid provided by the embodiment of the invention on the medical mirror is integrally superior to that of the medical mirror antifogging fluid provided by the comparative example.

The medical mirror antifogging liquid provided by the invention is finally obtained through a large number of repeated tests, tests and adjustments, and is obtained by a large number of creative efforts. In this process, besides the basic characteristics of each raw material, the compatibility and interaction relationship between different raw materials are also balanced. The selection of various raw materials such as an active agent, a slow release agent, a toughening agent, water and the like and the adjustment of the use amount of the raw materials are controlled within the specific range of the invention, so that the mutual promotion of the raw materials can be ensured, the internal consumption is not generated, the formed medical mirror surface antifogging liquid can be rapidly formed into a film and can continuously prevent fog, the medical mirror surface antifogging liquid can be simply and conveniently washed clean without leaving traces after the operation is finished, and the functions are exerted according with the fluid mechanics principle. Meanwhile, the antifogging effect is not enhanced along with the increase of the concentration of various raw materials of the antifogging liquid, and the antifogging effect can be ensured and the cost can be reduced only by selecting proper raw material dosage.

Finally, it should be noted that: the above embodiments are only used to illustrate the technical solution of the present invention, and not to limit the same; while the invention has been described in detail and with reference to the foregoing embodiments, it will be understood by those skilled in the art that: the technical solutions described in the foregoing embodiments may still be modified, or some or all of the technical features may be equivalently replaced; and the modifications or the substitutions do not make the essence of the corresponding technical solutions depart from the scope of the technical solutions of the embodiments of the present invention.

Claims

1. The medical mirror antifogging fluid is characterized by comprising the following components in percentage by weight: 3-15% of active agent, 10-35% of slow release agent, 2-20% of toughening agent and 40-85% of water;

the sustained release agent comprises a polyhydric alcohol;

2. The medical mirror antifogging fluid of claim 1, comprising the following components in percentage by weight: 3.5 to 14.9 percent of active agent, 11 to 34 percent of slow release agent, 3 to 16 percent of toughening agent and 45 to 80 percent of water;

3. The medical mirror antifogging fluid of claim 1 or 2, wherein the mass ratio of the biorefinent to the ethanol in the toughening agent is (0.05-5): (1-35);

preferably, the biorefining agent is a hyaluronate;

preferably, the hyaluronic acid salt comprises sodium hyaluronate;

preferably, the water is purified water.

4. The method for preparing a medical mirror antifogging fluid according to any one of claims 1 to 3, comprising the steps of:

preferably, the step of standing is also included after mixing;

preferably, the standing time is 1-24 h.

5. A medical mirror antifogging film, which is characterized by being prepared from the medical mirror antifogging fluid of any one of claims 1 to 3 or the medical mirror antifogging fluid prepared by the preparation method of the medical mirror antifogging fluid of claim 4.

6. The method for preparing the medical mirror antifogging film according to claim 5, comprising the steps of:

7. The method for preparing a medical mirror antifogging film according to claim 6, wherein in the step (a), the wet carrier wetted by the medical mirror antifogging solution is prepared by the following steps:

preferably, in the step (a), the weight gain rate of the carrier is 137-178%;

preferably, in step (a), the wet film thickness is from 8 to 15 μm;

preferably, in step (a), the standing time is 3-5 min.

8. An anti-fogging method for anti-fogging a medical mirror surface using the medical mirror surface anti-fogging liquid according to any one of claims 1 to 3, comprising the steps of:

9. The anti-fogging method according to claim 8, wherein in step (a), the wet carrier wetted with the medical mirror-like anti-fogging liquid is prepared by the following steps:

preferably, in the step (a), the weight gain rate of the carrier is 137-178%;

preferably, in step (a), the wet film thickness is from 8 to 15 μm;

preferably, in step (a), the standing time is 3-5 min.

10. A medical device, wherein the medical mirror surface of the medical device is obtained by performing an antifogging treatment using the medical mirror surface antifogging fluid according to any one of claims 1 to 3, the medical mirror surface antifogging film according to claim 5, or the antifogging method according to claim 8 or 9;