CN115137667A

CN115137667A - Cosmetic composition with permeation promoting effect and application thereof

Info

Publication number: CN115137667A
Application number: CN202210962137.XA
Authority: CN
Inventors: 杨志喜; 于忠国; 梁桓; 周沛媛; 储文进; 冯慧生; 郦轲
Original assignee: Shenzhen Accompany Technology Co Ltd
Current assignee: Shenzhen Accompany Technology Co Ltd
Priority date: 2022-08-11
Filing date: 2022-08-11
Publication date: 2022-10-04
Anticipated expiration: 2042-08-11
Also published as: CN115137667B

Abstract

The invention relates to a cosmetic composition with penetration-promoting effect and application thereof, wherein the cosmetic composition with penetration-promoting effect comprises bis-diethoxydiethylene diglycol cyclohexane 1, 4-dicarboxylate, ethoxy diglycol and transdermal short peptide TD-1. The invention creatively compounds three components, wherein, the bis-diethoxydiol cyclohexane 1, 4-dicarboxylate is a common penetration enhancer component, and the penetration enhancing effect is obviously amplified after the bis-diethoxydol cyclohexane 1, 4-dicarboxylate is combined with the transdermal short peptide TD-1 of the biological penetration enhancer, and is obviously improved compared with the penetration enhancing effect of a single component, and an obvious synergistic effect is obtained; and the permeation promoting effect of the further compounding of the ethoxy diglycol is further improved. The composition can be added into various cosmetics according to requirements, has strong compatibility, does not influence the efficacy performance of the original functional components, and can remarkably promote the percutaneous absorption of the functional components such as whitening, wrinkle removing, moisturizing, anti-allergy and anti-oxidation components, so that the bioavailability is improved.

Description

Cosmetic composition with permeation promoting effect and application thereof

Technical Field

The invention belongs to the technical field of cosmetics, and relates to a cosmetic composition with a penetration-promoting effect and application thereof.

Background

In recent years, with the development of science and technology and the improvement of living standard, people have demanded a plurality of efficacies from the basic appeal of simple skin care, and the effective absorption and utilization of efficacy active substances become more important to exert the efficacies. However, the stratum corneum at the outermost layer of the epidermis of the skin has a barrier function, so that the stratum corneum can defend against foreign matters and external stimuli, prevent most of functional active substances from passing through, and only a few small molecular active substances can pass through in a small amount. The efficacy actives stay on the top layer of the skin and are not delivered to the corresponding site of action. The transdermal absorption of cosmetics is very important, which is a key point affecting whether cosmetics are effective. The more the functional components absorbed by the skin, the more remarkable the effect.

There are various ways of influencing the transdermal absorption of the active ingredients on the skin, mainly including the following:

1. the skin structure is changed, and the diffusivity of the effective components in the skin is improved. The theory suggests that after the penetration enhancer enters the skin, the lipid-like structure in the stratum corneum is destroyed, the ordered stack structure of the flat keratinocytes is changed, the order of lipid arrangement is reduced, and the lipid is completely fluidized, so that the functional components are promoted to pass through smoothly.

2. Hydration technology, when the skin absorbs a large amount of water and is fully hydrated, the stratum corneum can expand into a porous state, the barrier function is reduced, and thus the penetration of substances is facilitated; skin hydration generally facilitates transdermal absorption. Since the cells themselves swell when the hydration force of nitrogen-containing substances in the keratin of the cells of the stratum corneum is increased, the degree of compaction of the structure is reduced and the permeability of the substance is increased. In this case, water-soluble and polar substances are more easily permeated from the stratum corneum cells. So moisturizers are often added to cosmetics to improve the absorption of the active ingredients.

3. The penetration enhancer is added, so that the penetration enhancer can be absorbed through the skin to overcome the barrier of the skin stratum corneum, the barrier effect of the skin stratum corneum can be changed reversibly, any active cells are not damaged, the solubility of the drug in the skin is increased, and the purpose of increasing the transdermal absorption rate of the drug is achieved.

For example, CN102579276A discloses a safe moisturizing and penetration-promoting composition for cosmetics, which mainly comprises amino acid humectant, sodium hyaluronate, niacinamide, allantoin and deionized water. The composition is mainly completed according to the principle that the water content of the stratum corneum is a function of the relative humidity of the environment, and the stratum corneum can be expanded into a porous state after hydration, so that the stratum corneum is easy to penetrate substances, and potential harm can not be caused to the skin.

For example, CN113855584A discloses a transdermal penetration enhancing composition prepared from multiple oils and fats, and a preparation method and application thereof, wherein the composition comprises one or more of oleic acid or oleic acid derivatives or glyceryl oleate; one or more of linoleic acid or a linoleic acid derivative or glyceryl linoleate; one or more of phospholipids or glycolipids or glycosphingolipids. Through the combination of the penetration enhancers, compared with the penetration enhancer with a single component, the transdermal penetration rate and the accumulated penetration rate are both obviously improved, and the penetration absorption of the skin to the effective components is promoted through multiple functions, so that the water-soluble and oil-soluble active components of the cosmetic are easier to penetrate, and the biocompatibility and the utilization rate of the cosmetic are improved.

The addition of penetration enhancers is the most common penetration enhancing method used up to now, but the formulation of effective penetration enhancers is limited, so it is necessary to develop more safe and effective penetration enhancers.

Disclosure of Invention

In view of the shortcomings of the prior art, the invention aims to provide a cosmetic composition with penetration-promoting efficacy and application thereof.

In order to achieve the purpose, the invention adopts the following technical scheme:

in a first aspect, the present invention provides a cosmetic composition having penetration-enhancing efficacy, which comprises bis-diethoxydiol cyclohexane 1, 4-dicarboxylate, ethoxydiglycol and transdermal short peptide TD-1.

The invention creatively compounds three components of bis-diethoxy diglycol cyclohexane 1, 4-dicarboxylate, ethoxy diglycol and transdermal short peptide TD-1, wherein the bis-diethoxy diglycol cyclohexane 1, 4-dicarboxylate is a common penetration enhancer component, and the penetration enhancer is remarkably amplified after being combined with the transdermal short peptide TD-1 of the biological penetration enhancer, remarkably improves the penetration enhancer compared with a single component, and obtains remarkable synergy; and the permeation promoting effect of the further compounding of the ethoxy diglycol is further improved. The invention integrates the bis-diethoxydiol cyclohexane 1, 4-dicarboxylate, the ethoxy diglycol and the transdermal short peptide TD-1 into a whole through scientific compatibility, thereby realizing the function of integral comprehensive effect, wherein the components have division and cooperation, have synergy and restriction, and have potential synergy promotion relationship.

Preferably, the cosmetic composition with the penetration-promoting effect comprises 1 to 2 parts of bis-diethoxydiol cyclohexane 1, 4-dicarboxylate, 1 to 2 parts of ethoxy diglycol and 1 to 12 parts of transdermal short peptide TD-1 in parts by mass.

The bis-diethoxydiol cyclohexane 1, 4-dicarboxylate can be 1 part, 1.2 parts, 1.4 parts, 1.6 parts, 1.8 parts, 2 parts and the like by mass.

The ethoxy diglycol can be 1 part, 1.2 parts, 1.4 parts, 1.6 parts, 1.8 parts, 2 parts and the like in parts by mass.

The transdermal short peptide TD-1 can be 1 part, 2 parts, 3 parts, 4 parts, 5 parts, 6 parts, 7 parts, 8 parts, 9 parts, 10 parts, 12 parts and the like in parts by mass.

Other specific point values within the above numerical ranges can be selected, and are not described in detail herein.

The three components of the composition provided by the invention have more remarkable penetration promoting effect when meeting the mass ratio relationship.

In a second aspect, the present invention provides the use of a cosmetic composition according to the first aspect having penetration enhancing effect in the preparation of a cosmetic.

The composition can be added into various cosmetics according to needs, has strong compatibility, does not influence the efficacy exertion of the original functional components, and can also obviously promote the percutaneous absorption of the functional components such as whitening, wrinkle removing, moisture preserving, anti-allergy and anti-oxidation components, so that the bioavailability is improved.

Preferably, the content of the cosmetic composition with penetration enhancing effect in the cosmetic is 0.1-10% by mass, such as 0.1%, 0.3%, 0.5%, 0.7%, 1%, 2%, 3%, 4%, 5%, 6%, 7%, 8%, 9%, 10%, etc., and other specific values in the numerical range can be selected, which is not described in detail herein.

Preferably, the cosmetic comprises a facial mask, a lotion, an essence, a lotion, a facial mask and a makeup remover.

Preferably, the cosmetic is used directly or in combination with a radio frequency cosmetic apparatus.

The composition is preferably used by matching with instruments such as a radio frequency beauty instrument and the like, molecules are driven to penetrate through a horny layer through electrophoresis, meanwhile, micro-current generates heat energy, local blood circulation is promoted, the penetration of effective components is further promoted, the ideal distribution between the effective components and a target part is realized, and the penetration of the effective components in cosmetics is promoted in a multi-angle mode by combining a chemical penetration promoting technology, a physical penetration promoting technology and a biological penetration promoting technology.

In a third aspect, the present invention provides a mask having skin whitening and wrinkle-removing effects, comprising: the cosmetic composition and the efficacy ingredient having penetration enhancing effect according to the first aspect.

Preferably, the mask having skin whitening and wrinkle removing effects further comprises an emulsifier moisturizer, a thickener, a chelating agent, a pH adjuster, a preservative, a fragrance, and water.

Compared with the prior art, the invention has the following beneficial effects:

the invention creatively compounds three components of bis-diethoxy diglycol cyclohexane 1, 4-dicarboxylate, ethoxy diglycol and transdermal short peptide TD-1, wherein the bis-diethoxy diglycol cyclohexane 1, 4-dicarboxylate is a common penetration enhancer component, and the penetration enhancer component is combined with the biological penetration enhancer transdermal short peptide TD-1 to obviously amplify the penetration effect, so that the penetration enhancer is obviously improved compared with a single component, and an obvious synergistic effect is obtained; and the permeation promoting effect of further compounding the ethoxy diglycol is further improved. The invention integrates the bis-diethoxydiethylene diglycol cyclohexane 1, 4-dicarboxylate, ethoxy diglycol and transdermal short peptide TD-1 into a whole through scientific compatibility, thereby realizing the effect of 'comprehensive effect taking' as a whole, wherein, the components have division and cooperation, have synergy and restriction, and have potential synergy promotion relationship.

The composition is preferably used by matching with instruments such as a radio frequency beauty instrument and the like, molecules are driven to penetrate through a horny layer through electrophoresis, meanwhile, micro-current generates heat energy, local blood circulation is promoted, the permeation of effective components is further promoted, the ideal distribution between the effective components and a target part is realized, and the permeation of the effective components in cosmetics is promoted in a multi-angle mode by combining a chemical permeation promoting technology, a physical permeation promoting technology and a biological permeation promoting technology.

Detailed Description

In order to further illustrate the technical means and effects of the present invention, the technical solutions of the present invention are further described below with reference to the preferred embodiments of the present invention, but the present invention is not limited to the scope of the embodiments.

The following examples and comparative examples refer to the following sources of raw materials:

nonapeptide-1 was obtained from knowa biotechnology limited, guangzhou;

fibronectin was purchased from Guangzhou and institute of biomedical research, inc.;

the hydrolyzed cod skin protein is obtained from Gansu Boshikang chemical science and technology Co.Ltd;

DNA sodium was purchased from Youmiss Biotechnology (Weihai) Ltd;

bis-diethoxydiethylene glycol cyclohexane 1, 4-dicarboxylate is available from NIPPON FINE CHEMICAL CO., LTD;

ethoxydiglycol is available from dow chemical (shanghai) ltd;

transdermal short peptide TD-1 was obtained from Fujian Longsheng Biotech limited.

Example 1

This example provides a cosmetic composition with penetration enhancing effect, which comprises 1 part of bis-diethoxydiol cyclohexane 1, 4-dicarboxylate, 1 part of ethoxy diglycol and 1 part of transdermal short peptide TD-2.

Example 2

This example provides a cosmetic composition with penetration enhancing effect, which comprises 2 parts of bis-diethoxydiol cyclohexane 1, 4-dicarboxylate, 2 parts of ethoxy diglycol and 1 part of transdermal short peptide TD-1.

Example 3

This example provides a cosmetic composition with penetration enhancing effect, which comprises 1 part of bis-diethoxydiol cyclohexane 1, 4-dicarboxylate, 1 part of ethoxydiglycol and 1 part of transdermal short peptide TD-1.

Example 4

This example provides a cosmetic composition with penetration-enhancing effect, which comprises 1 part of bis-diethoxydiol cyclohexane 1, 4-dicarboxylate, 2 parts of ethoxy diglycol and 1 part of transdermal short peptide TD-12.

Example 5

This example provides a cosmetic composition with penetration-enhancing effect, which comprises 2 parts of bis-diethoxydiol cyclohexane 1, 4-dicarboxylate, 1 part of ethoxy diglycol and 1 part of transdermal short peptide TD-12.

Comparative example 1

This comparative example provides a composition consisting of 1 part of bis-diethoxydiethylene glycol cyclohexane 1, 4-dicarboxylate and 1 part of ethoxydiglycol.

Comparative example 2

This comparative example provides a composition consisting of 1 part of bis-diethoxydiethylene glycol cyclohexane 1, 4-dicarboxylate and 1 part of transdermal short peptide TD-2.

Comparative example 3

The comparative example provides a composition consisting of 1 part of ethoxydiglycol and 1 part of transdermal short peptide TD-2.

Comparative examples 4 to 6

Comparative examples 4-6 provide single components bis-diethoxydiethylene glycol cyclohexane 1, 4-dicarboxylate, ethoxydiglycol, and transdermal short peptide TD-1, respectively.

Test example 1

Penetration test of rat skin

(1) The test method comprises the following steps:

(1.1) first, a test sample is prepared: adding deionized water into a 100 ml beaker, stirring and heating to 80 ℃, keeping the stirring speed at 40 rpm, stirring for 20 minutes at a constant temperature, adding 0.8 percent of 1, 2-hexanediol, continuing to keep the temperature and stirring for 10 minutes, finishing the temperature keeping, cooling to 35 ℃, adding 0.2 percent of fibronectin and 0.4 percent of the composition products of examples 1-5 and comparative examples 1-6, supplementing the deionized water to 100 percent, and stirring for 3 minutes.

(1.2) formal test:

intact treated isolated SD female rat (6-8 weeks, 170-250g in body weight) was used for dorsal skin testing using vertical Franz diffusion cell method, the amount of skin penetrating composition was measured dynamically over time, and the permeability coefficient Px 10 was calculated ^-3 (cm/h)。

(2) The test method comprises the following steps:

(2.1) first, a test sample is prepared: the method of (1.1) differs only in that fibronectin was replaced with an equivalent amount of nonapeptide-1, and the other procedures were all identical.

(2.2) is the same as (1.2).

(3) The test method comprises the following steps:

(3.1) first, a test sample is prepared: the only difference from the method of (1.1) was that fibronectin was replaced with an equal amount of hydrolysed gadidae skin protein, and the other manipulations were all identical.

(3.2) is the same as (1.2).

(4) The test method comprises the following steps:

(4.1) first, a test sample is prepared: the method of (1.1) was different only in that fibronectin was replaced with an equal amount of DNA sodium, and the other operations were all identical.

(4.2) is the same as (1.2).

Permeability coefficient P × 10 for each of the above tests ^-3 (cm/h) the results are shown in Table 1:

TABLE 1

Group of	Fibrin	Nonapeptide-1	Hydrolyzing skin protein of cod family	DNA sodium salt
					Example 1	53.327±1.124	67.462±2.249	52.417±2.371	58.724±2.376
Example 2	56.126±2.025	70.235±1.921	54.634±2.112	62.023±2.073
					Example 3	51.327±1.641	64.814±2.421	51.107±1.968	56.902±1.671
Example 4	48.653±2.436	62.172±2.153	49.375±1.872	53.217±1.764
					Example 5	48.158±1.387	61.875±2.744	48.754±2.027	53.014±2.424
Comparative example 1	35.454±2.432	48.382±2.639	34.724±1.974	39.342±1.835
					Comparative example 2	38.136±1.475	47.374±2.285	36.836±1.974	40.216±2.428
Comparative example 3	38.047±1.736	48.012±2.449	36.457±1.457	40.457±2.536
					Comparative example 4	32.451±1.838	40.413±1.279	31.411±1.043	35.475±1.754
Comparative example 5	32.637±1.958	39.868±2.108	31.752±2.121	34.721±2.465
					Comparative example 6	35.122±2.076	37.546±1.951	33.424±2.557	34.457±2.175

As can be seen from the data in Table 1: the cosmetic composition has a good permeation promoting effect on various functional components, and the bis-diethoxydiol cyclohexane 1, 4-dicarboxylate, ethoxy diglycol and transdermal short peptide TD-1 have a remarkable synergistic effect.

Application example 1

The application example provides a facial mask with anti-aging and whitening effects, which comprises the following raw materials:

the component A comprises: coco-caprylate/caprate 3%, hydrogenated polyisobutene 7%, dioctyl carbonate 4%, octyldodecanol 7%, C14-22 alcohol 3%, cetearyl alcohol 1%, caprylic/capric triglyceride 2%;

and B component: 1% of sorbitan olivate, 6% of glycerol, 1, 3-propylene glycol, 0.5% of xanthan gum and deionized water to 100%;

and C, component C: ergothioneine 1%, nicotinamide 1%, astaxanthin 0.5%, penetration enhancing composition of example 1 0.5%, phenoxyethanol 0.05%.

The preparation method comprises the following steps:

(1) Mixing and homogenizing the raw materials of the component A at 65 ℃ for 5min to obtain an oil phase; mixing and homogenizing the raw materials of the component B at 55 deg.C for 5min to obtain water phase;

(2) Mixing the oil phase and the water phase at 55 deg.C, homogenizing for 10min, cooling to 40 deg.C, mixing with the raw materials of component C, homogenizing, vacuumizing, and cooling to 30 deg.C.

Application examples 2 to 5

4 facial masks with the functions of resisting senility and whitening are provided, the raw material formula of the facial masks is only different from the application example 1 in that the penetration-promoting composition in the example 1 is respectively replaced by the penetration-promoting compositions in the examples 2-5 in an equal amount, other components are kept unchanged, and the preparation method is the same as the application example 1.

Comparative application examples 1 to 6

6 kinds of face masks were provided, which were different from application example 1 only in that the penetration enhancing composition of example 1 was respectively replaced with the compositions of comparative examples 1 to 6 in equal amounts, and the other ingredients were kept unchanged, and the preparation method was the same as application example 1.

Comparative application example 7

A facial mask is provided, wherein the raw material formula of the facial mask is different from that of application example 1 only in that the penetration promoting composition in the example 1 is not contained, the content of the penetration promoting composition is complemented by deionized water, other components are kept unchanged, and the preparation method is the same as that of the application example 1.

Test example 2

Human body evaluation test of whitening effect and anti-aging effect:

120 female volunteers aged 18-50 are selected, the facial mask products of application examples 1-5 and comparative application examples 1-7 are respectively used on the face for 1 time in the morning and evening, the operation is kept consistent as much as possible, and the facial mask products are used for 8 weeks. The change in melanin content of the skin of the subject after application of the mask product was evaluated using a skin melanin tester. The measuring range of the used instrument is 0-999, and the higher the measuring value is, the higher the melanin content on the skin is. The reduction of melanin in the face before and after the subject used the product is shown in table 2; the skin elasticity tester MPA580 is adopted for testing, MPA software is adopted for analyzing the elasticity performance of the skin, the ratio of the resilience amount of the skin without negative pressure to the maximum stretching amount of the skin with negative pressure is taken as an evaluation index, the closer the ratio is to 1, the better the elasticity is, and the results are shown in Table 2.

TABLE 2

As can be seen from the data in Table 2: the cosmetic composition has a good permeation promoting effect on functional components in cosmetics, and can make the functional components more fully effective. And the bis-diethoxydiethylene diglycol cyclohexane 1, 4-dicarboxylate, ethoxy diglycol and transdermal short peptide TD-1 have obvious synergistic effect.

The applicant states that the present invention is illustrated by the above examples to a cosmetic composition with penetration enhancing effect and its application, but the present invention is not limited to the above examples, i.e. it does not mean that the present invention must be implemented by the above examples. It should be understood by those skilled in the art that any modification of the present invention, equivalent substitutions of the raw materials of the product of the present invention, addition of auxiliary components, selection of specific modes, etc., are within the scope and disclosure of the present invention.

The preferred embodiments of the present invention have been described in detail, however, the present invention is not limited to the specific details of the above embodiments, and various simple modifications may be made to the technical solution of the present invention within the technical idea of the present invention, and these simple modifications are all within the protection scope of the present invention.

It should be noted that, in the above embodiments, the various features described in the above embodiments may be combined in any suitable manner, and in order to avoid unnecessary repetition, the present invention does not separately describe various possible combinations.

Claims

1. A cosmetic composition with penetration-promoting effect comprises bis-diethoxydiol cyclohexane 1, 4-dicarboxylate, ethoxy diglycol and transdermal short peptide TD-1.

2. The cosmetic composition with penetration enhancing effect according to claim 1, wherein the cosmetic composition with penetration enhancing effect comprises 1 to 2 parts by mass of bis-diethoxydiol cyclohexane 1, 4-dicarboxylate, 1 to 2 parts by mass of ethoxydiglycol and 1 to 12 parts by mass of transdermal short peptide TD-1.

3. Use of a cosmetic composition with penetration enhancing effect according to claim 1 or 2 for the preparation of a cosmetic.

4. The use according to claim 3, characterized in that the cosmetic composition with penetration enhancing effect is present in the cosmetic in an amount of 0.1 to 10% by weight.

5. The use according to claim 3, wherein the cosmetic comprises a mask, a lotion, a serum, a lotion, a mask, a makeup remover.

6. Use according to claim 3, characterized in that said cosmetic product is used directly or in combination with a radiofrequency cosmetic instrument.

7. A mask having whitening and wrinkle-removing effects, characterized in that it comprises: the cosmetic composition and the efficacy ingredient having penetration enhancing effect according to claim 1 or 2.

8. The mask having whitening and wrinkle-removing effects according to claim 7, further comprising an emulsifier, a humectant, a thickener, a chelating agent, a pH-adjusting agent, a preservative, an aromatic and water.