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CN114881924B - Quantitative analysis device based on ultrasonic image elastic signals - Google Patents

Quantitative analysis device based on ultrasonic image elastic signals Download PDF

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CN114881924B
CN114881924B CN202210323622.2A CN202210323622A CN114881924B CN 114881924 B CN114881924 B CN 114881924B CN 202210323622 A CN202210323622 A CN 202210323622A CN 114881924 B CN114881924 B CN 114881924B
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elastic
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texture
elastic signal
color saturation
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CN114881924A (en
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于明
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Shiwei Xinzhi Medical Technology Shanghai Co ltd
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    • GPHYSICS
    • G06COMPUTING; CALCULATING OR COUNTING
    • G06TIMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T7/00Image analysis
    • G06T7/0002Inspection of images, e.g. flaw detection
    • G06T7/0012Biomedical image inspection
    • GPHYSICS
    • G06COMPUTING; CALCULATING OR COUNTING
    • G06TIMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T7/00Image analysis
    • G06T7/90Determination of colour characteristics
    • GPHYSICS
    • G06COMPUTING; CALCULATING OR COUNTING
    • G06TIMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T2207/00Indexing scheme for image analysis or image enhancement
    • G06T2207/10Image acquisition modality
    • G06T2207/10132Ultrasound image
    • GPHYSICS
    • G06COMPUTING; CALCULATING OR COUNTING
    • G06TIMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T2207/00Indexing scheme for image analysis or image enhancement
    • G06T2207/30Subject of image; Context of image processing
    • G06T2207/30004Biomedical image processing
    • G06T2207/30068Mammography; Breast
    • GPHYSICS
    • G06COMPUTING; CALCULATING OR COUNTING
    • G06TIMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T2207/00Indexing scheme for image analysis or image enhancement
    • G06T2207/30Subject of image; Context of image processing
    • G06T2207/30004Biomedical image processing
    • G06T2207/30096Tumor; Lesion

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Abstract

The invention relates to a quantitative analysis device based on an ultrasonic image elastic signal, which comprises: an image acquisition module: for acquiring ultrasound images with nodules; elastic signal acquisition module: the method comprises the steps of obtaining an elastic signal according to the ultrasonic image; signal purity analysis module: for calculating the color saturation of the elastic signal by color saturation analysis. The invention can effectively carry out quantitative analysis on the elastic information in the elastic ultrasonic image.

Description

Quantitative analysis device based on ultrasonic image elastic signals
Technical Field
The invention relates to the technical field of medical image processing, in particular to a quantitative analysis device based on an ultrasonic image elastic signal.
Background
Today, with increasing demand for rapid and accurate diagnosis, and shortage of clinical staff, computer analysis methods have been increasingly applied to assist conventional clinical diagnosis and show good effects. Taking breast cancer as an example, as the second leading fatal cancer in women worldwide, the mortality rate of breast cancer is as high as 15%. Timely diagnosis of breast cancer is critical to improving the life expectancy of females. The ultrasonic imaging is used as a noninvasive, non-radiative and low-cost tumor diagnosis technology, and can well assist clinicians in judging benign and malignant cancer symptoms. However, due to the low quality of ultrasound images, analysis of tumor nodules in ultrasound images is a challenging task and is highly susceptible to physician subjective factors, resulting in misdiagnosis. As one of potential solutions, the corresponding computer analysis method can well conduct quantitative and accurate analysis on the nodules of different pathological positions, so as to assist clinicians in making more accurate judgment and reducing misdiagnosis.
As an important basis for diagnosing various cancers, analysis of the signs of texture in ultrasound images plays a vital role in clinical examinations. Hard-textured nodules are more prone to attack surrounding normal tissue, exhibiting stronger malignancy characteristics; in contrast, soft-textured nodules are less prone to attack on surrounding normal tissue, exhibiting more benign features. Unfortunately, conventional ultrasound approaches are difficult to analyze the texture of nodules due to limitations in the principles of self imaging and the effects of surrounding proliferating tissue and various types of noise, which are highly prone to misdiagnosis. Elastic ultrasound is used as a novel ultrasonic imaging technology, and the softness of a scanned part can be expressed on an ultrasonic image in a color form by processing an acquired original ultrasonic signal, so that the defect that the traditional conventional ultrasound has poor tissue texture display effect is overcome. However, the conventional examination method is limited by the prior art, and only subjective or semi-subjective analysis can be performed on the texture information in the elastic ultrasonic image, so that the elastic ultrasonic technology is limited to be widely applied.
Disclosure of Invention
The invention aims to solve the technical problem of providing a quantitative analysis device based on an elastic signal of an ultrasonic image, which can effectively perform quantitative analysis on elastic information in the elastic ultrasonic image.
The technical scheme adopted for solving the technical problems is as follows: provided is a quantitative analysis device based on an ultrasound image elastic signal, comprising:
an image acquisition module: for acquiring ultrasound images with nodules;
elastic signal acquisition module: the method comprises the steps of obtaining an elastic signal according to the ultrasonic image;
Signal purity analysis module: for calculating the color saturation of the elastic signal by color saturation analysis.
The signal purity analysis module is used for analyzing the signal purity of the signalCalculating the color saturation of the elastic signal, wherein s e (x, y) represents the color saturation of the elastic signal and s e epsilon [0,1], max () represents the maximum value, min () represents the minimum value, R x,y represents the luminance value of the pixel (x, y) in the red channel, G x,y represents the luminance value of the pixel (x, y) in the green channel, and B x,y represents the luminance value of the pixel (x, y) in the blue channel.
The method further comprises a first judging module: when the color saturation s e of the elastic signal is larger than a preset saturation threshold, the elastic signal is indicated to be bright; and when the color saturation s e of the elastic signal is smaller than a preset saturation threshold, the blurring of the elastic signal is indicated.
Further comprises:
Elastic signal texture classification module: for classifying the texture of the elastic signals, the texture of the elastic signals comprising three types of soft, hard and moderate;
Elastic signal measuring module: for calculating an elasticity information measure based on the texture classification of the elasticity signal and the color saturation s e (x, y) of the elasticity signal.
The elastic signal measuring module passes throughCalculating an elasticity information measure value, wherein S e (x, y) is the elasticity information measure value, S e (x, y) represents the color saturation of the elasticity signal,Is an elastic weighting constant Is an elastic weighting coefficient andOmega e is the texture classification of elastic signals, soft means soft, medium means medium, hard; λ is the positive and negative operational coefficient and λ= +1 or-1.
The method further comprises a second judging module: when the elasticity information measure S e (x, y) is greater than the first texture threshold, then it is indicated that the texture of the ultrasound image at the pixel (x, y) is hard; the elasticity information measure S e (x, y) is less than the second texture threshold, indicating that the texture of the ultrasound image at the pixel (x, y) is soft; the elasticity information measure S e (x, y) lying between the first texture threshold and the second texture threshold indicates that the texture of the ultrasound image at pixel (x, y) is moderate.
Advantageous effects
Due to the adoption of the technical scheme, compared with the prior art, the invention has the following advantages and positive effects: the invention can effectively quantify the elastic information in the elastic ultrasonic image, makes up for the short plate which has insufficient accuracy of naked eye analysis and lacks consistency, greatly improves the film reading efficiency of the ultrasonic doctor, increases the diagnosis accuracy and greatly assists the daily work of the ultrasonic doctor.
Drawings
FIG. 1 is a flow chart of an embodiment of the present invention;
FIG. 2 is a diagram showing the result of extracting color saturation of an elastic signal according to an embodiment of the present invention;
Fig. 3 is a schematic diagram of the extraction result of the elasticity information measure value in the embodiment of the present invention.
Detailed Description
The application will be further illustrated with reference to specific examples. It is to be understood that these examples are illustrative of the present application and are not intended to limit the scope of the present application. Furthermore, it should be understood that various changes and modifications can be made by one skilled in the art after reading the teachings of the present application, and such equivalents are intended to fall within the scope of the application as defined in the appended claims.
An embodiment of the present invention relates to a quantitative analysis device based on an elastic signal of an ultrasound image, referring to fig. 1, including:
an image acquisition module: for acquiring ultrasound images with nodules;
elastic signal acquisition module: the method comprises the steps of obtaining an elastic signal according to the ultrasonic image;
Signal purity analysis module: the color saturation of the elastic signal is calculated through a color saturation analysis method;
Elastic signal texture classification module: for classifying the texture of the elastic signals, the texture of the elastic signals comprising three types of soft, hard and moderate;
elastic signal measuring module: for calculating an elasticity information measure based on the texture classification of the elasticity signal and the color saturation of the elasticity signal.
The present embodiment will be described in detail below:
the sonographer can classify the scanned site roughly or shallowly by reading the elastic ultrasound image. However, when the elastic ultrasonic image is disordered and unobtrusive, accurate interpretation of the elastic information is often difficult to achieve based on naked eye judgment, so that more accurate measurement of conventional elastic information is required.
Further, the elastic signal acquisition module includes:
And a detection unit: the method comprises the steps of extracting a color region I c in an ultrasonic image through a threshold value judging method based on RGB channels, searching color pixels in the color region I c by taking eight neighborhood as a radius to obtain a plurality of independent connected domains, selecting the connected domain with the largest area in all the connected domains, and fitting the smallest boundary frame of the connected domain with the largest area to obtain an elastic signal region I e;
Extraction unit: for extracting the elastic signal in the elastic signal region I e by RGB color channel luminance comparison.
Further, the formula of the threshold judgment method in the detection unit is as follows:
Wherein Coloured (x, y) is the identification result of ultrasound at the pixel (x, y), true represents the identification result is color, false represents the identification result is black and white, G (x,y) is the brightness value of the pixel (x, y) on the green channel of the ultrasound image, R (x,y) is the brightness value of the pixel (x, y) on the red channel of the ultrasound image, B (x,y) is the brightness value of the pixel (x, y) on the blue channel of the ultrasound image, thr is a preset threshold.
Further, the extraction unit is provided with a plurality of extraction unitsExtracting elastic signals in the elastic signal region I e, wherein CheckInfo (x, y) is an elastic signal extraction result of the elastic ultrasonic image at the pixel (x, y), the pixel (x, y) is located in the elastic signal region I e, D e represents a channel decision equation, C (x,y) represents a luminance value of the elastic signal region I e at the pixel (x, y) in the channel C, (c\c) (x,y) represents a set of luminance values of the elastic signal region I e at the pixel (x, y) in two other channels except the channel C, and L c is an elastic conversion coefficient; when using blue to indicate soft property, red to indicate hard property, { L R=250,LG=150,LB =50 }; when a red color is used to indicate a soft property, a blue color indicates a hard property, { L R=50,LG=150,LB =250 }.
The embodiment can obtain the extracted elastic information classification image, and the image can well mark the elastic information in the nodule. In addition, the present embodiment also measures the ratio of various elastic signals in the nodule area, and three types are classified into hard, soft and medium. If ω e e { soft, medium, hard } is used to represent the required category, the calculation formula can be specifically expressed as:
Wherein X e represents the set of all pixels marked in the elastic signal region I e, X ROI represents the set of all pixels in the nodule region, 1 * In (a) is an indication function, when the return value of the elastic signal extraction equation CheckInfo (x, y) belongs toReturning to 1 if the time is short, otherwise returning to 0; Is an indication function, returns 1 when pixel (X, y) is within the region indicated by X ROI, otherwise returns 0, Is a lookup value for the sought elastic class and is defined as { t soft=50,tmedium=150,thard =250 } in terms of the elastic transformation coefficient L c. The higher the measured hard floor ratio using this metering method, the more hard components in the nodule region are indicated, whereas the higher the measured soft floor ratio, the more soft components in the nodule region are indicated.
In examinations using elastic ultrasound, the sonographer often uses the color change as a viewing basis to determine the texture of the site being scanned. However, due to the deficiency and difference of the sensitivity of human eyes to various colors, accurate and consistent interpretation of various colors and changes thereof is difficult, so that the misdiagnosis rate is improved. Therefore, the elastic ultrasonic image is analyzed based on the principle of color saturation analysis, so that the purity of various signals in the elastic ultrasonic image is accurately estimated, and further, the quantitative analysis of the elastic information is realized. In the signal purity analysis module, the characteristics of each pixel in the RGB color space are specifically utilized for comparison, and if R x,y、Gx,y and B x,y are used to respectively refer to the brightness values in the red, green and blue channels at the (x, y) position of the target pixel, the calculation process of the color saturation s e of the elastic signal can be specifically expressed as follows:
Where max () represents the maximum value and min () represents the minimum value, s e e [0,1]. The present embodiment further includes a first determination module: when the color saturation s e of the elastic signal is greater than a preset saturation threshold, the elastic signal is indicated to be bright (pure); when the color saturation s e of the elastic signal is smaller than the preset saturation threshold, the blurring (not pure) of the elastic signal is indicated.
Referring to fig. 2, (a) shows a breast ultrasound image with elastic signals, and white boxes are elastic signal areas; (b) As a result of the calculation of the saturation of the elastic color in the elastic signal region, it is easy to find that the higher the saturation of the color, the purer the color of the corresponding pixel.
Further, in the elastic signal measurement module, a specific calculation formula of the elastic information measurement value is:
Wherein S e (x, y) is an elasticity information measure, As elastic weighting constants, the classification according to different elasticity is defined as:
as the elastic weighting coefficients, it is defined by different elastic classifications:
Wherein soft indicates soft texture, medium indicates hard texture, λ is positive and negative coefficient of operation, and λ= +1 if the elastic signal reading of hard texture is greater than the elastic signal reading of soft texture at (x, y) when the texture classification ω e of the elastic signal is medium (medium); if the elastic signal reading for hard property is smaller than the elastic signal reading for soft property at (x, y), λ= -1. It is understood here that there are three channel readings for each pixel (x, y), and that when the texture ω e is medium, the readings for the corresponding channels of soft and hard need to be compared again to determine the assigned value of λ.
The present embodiment further includes a second judging module: the elasticity information measure S e (x, y) is between 0 and 1, and when the elasticity information measure S e (x, y) is greater than the first texture threshold, it indicates that the texture of the ultrasound image at the pixel (x, y) is hard; the elasticity information measure S e (x, y) is less than the second texture threshold, indicating that the texture of the ultrasound image at the pixel (x, y) is soft; the elasticity information measure S e (x, y) lying between the first texture threshold and the second texture threshold indicates that the texture of the ultrasound image at pixel (x, y) is moderate.
Referring to fig. 3, (a) a breast ultrasound image with elastic signals, white boxes are elastic signal areas; (b) For the extracted elastic information measure value, it is not difficult to find that the higher the elastic information measure value is, the brighter the corresponding pixel is.
Therefore, the invention can effectively quantify the elastic information in the elastic ultrasonic image, make up for the short plates which have insufficient accuracy of naked eye analysis and lack of consistency, greatly improve the film reading efficiency of the ultrasonic doctor and increase the diagnosis accuracy, and greatly assist the daily work of the ultrasonic doctor.
The foregoing descriptions of specific exemplary embodiments of the present invention are presented for purposes of illustration and description. It is not intended to limit the invention to the precise form disclosed, and obviously many modifications and variations are possible in light of the above teaching. The exemplary embodiments were chosen and described in order to explain the specific principles of the invention and its practical application to thereby enable one skilled in the art to make and utilize the invention in various exemplary embodiments and with various modifications as are suited to the particular use contemplated. It is intended that the scope of the invention be defined by the claims and their equivalents.

Claims (4)

1. A quantitative analysis device based on an ultrasound image elastic signal, comprising:
an image acquisition module: for acquiring ultrasound images with nodules;
elastic signal acquisition module: the method comprises the steps of obtaining an elastic signal according to the ultrasonic image;
Signal purity analysis module: the color saturation of the elastic signal is calculated through a color saturation analysis method;
Elastic signal texture classification module: for classifying the texture of the elastic signals, the texture of the elastic signals comprising three types of soft, hard and moderate;
elastic signal measuring module: the method comprises the steps of calculating an elasticity information measure value according to the texture classification of an elasticity signal and the color saturation of the elasticity signal; wherein the elastic signal measuring module passes through Calculating an elasticity information measure value, wherein S e (x, y) is the elasticity information measure value, S e (x, y) represents the color saturation of the elasticity signal,Is an elastic weighting constant Is an elastic weighting coefficient andOmega e is the texture classification of elastic signals, soft means soft, medium means medium, hard; λ is the positive and negative operational coefficients, λ= +1 when the elastic signal reading of the hard property is greater than the elastic signal reading of the soft property at (x, y), and λ= -1 when the elastic signal reading of the hard property is less than the elastic signal reading of the soft property at (x, y).
2. The quantitative analysis device based on ultrasound image elastic signals according to claim 1, wherein the signal purity analysis module is configured to analyze the elastic signals byCalculating the color saturation of the elastic signal, wherein s e (x, y) represents the color saturation of the elastic signal and s e epsilon [0,1], max () represents the maximum value, min () represents the minimum value, R x,y represents the luminance value of the pixel (x, y) in the red channel, G x,y represents the luminance value of the pixel (x, y) in the green channel, and B x,y represents the luminance value of the pixel (x, y) in the blue channel.
3. The quantitative analysis device based on ultrasound image elastic signals according to claim 1, further comprising a first judgment module: when the color saturation s e of the elastic signal is larger than a preset saturation threshold, the elastic signal is indicated to be bright; and when the color saturation s e of the elastic signal is smaller than a preset saturation threshold, the blurring of the elastic signal is indicated.
4. The quantitative analysis device based on an ultrasound image elastic signal according to claim 1, further comprising a second judgment module: when the elasticity information measure S e (x, y) is greater than the first texture threshold, then it is indicated that the texture of the ultrasound image at the pixel (x, y) is hard; the elasticity information measure S e (x, y) is less than the second texture threshold, indicating that the texture of the ultrasound image at the pixel (x, y) is soft; the elasticity information measure S e (x, y) lying between the first texture threshold and the second texture threshold indicates that the texture of the ultrasound image at pixel (x, y) is moderate.
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