CN103284677A - Imaging device for biological tissue observation - Google Patents
Imaging device for biological tissue observation Download PDFInfo
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- CN103284677A CN103284677A CN2012100530329A CN201210053032A CN103284677A CN 103284677 A CN103284677 A CN 103284677A CN 2012100530329 A CN2012100530329 A CN 2012100530329A CN 201210053032 A CN201210053032 A CN 201210053032A CN 103284677 A CN103284677 A CN 103284677A
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Abstract
The invention discloses an imaging device for biological tissue observation. The imaging device for biological tissue observation comprises an LED module, a driving circuit, a dodging and coupling device, a transmission optical system, an image signal recording device, an image signal acquisition device for automatically sampling a digitized signal at high speed, an image signal processing device and a switching device, wherein the chip of the LED module comprises at least two sets of LED chips with different central wavelengths, having a common anode or common cathode structure; each set of LED chip can be independently controlled; the transmission optical system can transmit light energy to a part required to be lighted; the signal recording device is a CCD (charge coupled device) or another recording component; and the image signal processing device can generate image signals in a plurality of bands through a reconstruction and synthesis technology for images in the different bands. The imaging device for biological tissue observation achieves a time-division multi-band multi-stage adjustable LED light-emitting technology and theoretically can achieve narrowband light imaging with any different central wavelengths; and through the switching device, ordinary wideband white light imaging can be further achieved.
Description
Technical field
The present invention relates to biological tissue research and medical science diagnosis and treatment field, particularly a kind ofly analyse by tissue is carried out the pathological change form credit, thus the imaging device that is used for biological tissue's observation that pathology and medical diagnosis on disease are effectively judged.
Background technology
The early lesion of biological tissue, as digestive tract, no matter be early cancer, malignant polyp, or mucosa heteroplasia, generally all with blood vessel hyperplasia, the focus surface organize the lines mutation, phenomenons such as tissue color is unusual, this is effective diagnosis and treatment means of judging that disease takes place, is the effective ways with pathological analysis observed to disease simultaneously.
Traditional biological tissue's observation procedure as conventional endoscopy, uses the xenon lamp white light to shine, and the reflected light of irradiated body surface is positioned in the charge-coupled device (CCD) of scope head end and catches.Because changing, organizational structure and blood flow can directly influence catoptrical spectrum composition, cause the spectrum of emission to be different from spectrum of reflected light, thereby make the contrast of organizing fine structure not high, be difficult to distinguish tumprigenicity and non-neoplastic lesion, cause the part disease to fail to pinpoint a disease in diagnosis.Development along with biomedical technology, endoscopic dye technology, magnifying endoscope technology, ultrasonic endoscope technology provide new method for the correct diagnosis of disease, but have objectively said above various methodologies and technology, for the discovery of early stage lesion tissue especially cancer, be still not enough.
Up-to-date arrowband imaging technique inserts a kind of revolvable interference narrow-band filter before the xenon lamp white light source, utilize hemoglobin respectively to the narrow glistening light of waves strong absorption characteristics of 415 nm and 540 nm, strengthen two kinds of optical wavelength and obtain contrast, realize the arrowband imaging of two kinds of wave bands, the vascularity situation in the mucosa is identified easily.Say that objectively this technology has produced effect energetically to medical diagnosis on disease, it is extensive to use future, but the employing narrow band pass filter has increased system bulk, has increased cost, and limited employed arrowband wave band number, can not realize the comprehensive observation of multiband to tissue.
At present, though the LED technology has obtained develop rapidly, and begin to be applied to fields such as illumination that color and the colour temperature of light are had relatively high expectations or demonstration.No matter but present LED module adopts traditional double pin led chip, still adopt common cathode or be total to the anode led chip, on each module all chip all in parallel or series connection generally can only send the light of specific band by single control circuit control, can not realize that multiwave spectrum freely launches.Prior art can only be finished multispectral emission by several LED module assembly units, causes equipment volume bigger, uses dumbly, and cost is higher.
Summary of the invention
For addressing the above problem, the object of the present invention is to provide employing can launch the LED module of multiple arrowband multiband light, and be applied to described biological tissue observation device, realize research and medical diagnosis to biological tissue.
For achieving the above object, technical scheme of the present invention is:
A kind of imaging device for biological tissue's observation comprises:
Arrowband multiband LED module, described arrowband multiband LED module comprises high thermal conductive substrate and led chip, described high thermal conductive substrate is metal basal board or ceramic substrate, described led chip is the led chip of the different centre wavelengths of at least two groups, the quantity of every group of led chip is at least one, every group of led chip is connected in series, and its wave band is identical or different, and led chip is for being total to anode or common cathode structure; Also be provided with line layer on the described high thermal conductive substrate, between described every group of led chip altogether anode or common cathode be electrically connected, the other end electrode of described every group of led chip draws independently to realize that by described line layer every group of led chip can independently control;
Drive circuit, it provides the working condition of low voltage and high current at described arrowband multiband LED module, can be the accurate control that realizes voltage or electric current;
Even optically coupled device, it provides coupling interface to the light that sends from arrowband multiband LED module, carries out secondary light-distribution;
The transmission optics system, it is transferred to the position that needs illumination with light energy, realizes required illumination zone and the illumination uniformity;
Image signal recording apparatus comprises CCD or cmos imaging element;
The picture signal harvester, it realizes the automatic high speed sampling of digitized signal, and to host computer transmission signal;
Image signal processing apparatus, it generates the picture signal of a plurality of wave bands by reconstruction and the synthetic technology of different-waveband image;
Switching device shifter is realized the switching of arrowband imaging and broadband visual light imaging.
Preferably, the centre wavelength scope of described led chip is that ultraviolet band is to infrared band.
Preferably, described every group of led chip is provided with independent separately and can controls the connecting and disconnecting of the circuit of corresponding group led chip and the control circuit of size of current.
Preferably, described even optically coupled system is arranged at multiband LED module rear end, arrowband.
Preferably, described transmission optics system is the combination that requires lens or the optical fiber structure of aspects such as the intensity of illumination that satisfies required illumination position, the uniformity.
Preferably, described transmission optics system and image signal recording apparatus all are positioned at the imaging device inside of biological tissue's observation usefulness, and have the connecting portion that can freely dismantle.
Preferably, described image processing apparatus comprises reconstruction and the image processing module and the record that synthesize of realizing image and analyzes a plurality of analysis modules that relate to biological tissue's key index parameter.
Preferably, described drive circuit is for realizing the constant-current drive circuit of the operate as normal demand under the big electric current high voltage of LED module.
Preferably, described imaging device for biological tissue observation also be provided with the picture signal that can obtain according to image processing apparatus, judge brightness of image whether at luminance standard with interior and carry out self-adjusting brightness adjusting device according to judged result.
Preferably, described image processing apparatus is provided with the image that can contrast two width of cloth different-wavebands, the multi-band image contrast module that also makes marks, is convenient to image is compared observation automatically to distinguishing tangible position.
Preferably, the described imaging device of observing for biological tissue also is provided with by the characteristic information of importing observed biological tissue, the information such as colour temperature when also carrying out imaging in conjunction with the employing broadband light, can be adjusted to the picture spectral band automatically, select one or more band of light to carry out imaging, and the imaging wave band of on the display screen panel operator being pointed out is selected module automatically
Show so that the display floater of paired observation and judgement when preferably, described imaging device for biological tissue's observation also is provided with the multi-band image that can realize different colours.
Preferably, described imaging device for biological tissue's observation also is provided with light energy Threshold Alerts device.
Adopt the beneficial effect of the technical program to be: owing to adopted the LED module that can realize a plurality of narrow band of light outgoing, thus the use of in described biological tissue observation device, having omitted optical filter and respective fixation anchor clamps thereof.This led light source module comprises the led chip of two groups of different centre wavelengths at least, and to the independent control of led chip employing grouping, realized the multistage adjustable LED luminescence technology of timesharing multiband, can realize the narrow band light outgoing of any a plurality of different centre wavelengths in theory, or the photoreactivation of multiple arrowband is luminous, thereby can pass through described biological tissue observation device, realization from ultraviolet to infrared multiwave imaging, obtain biological tissue's information of different-waveband, realize biological tissue's multiband multi-angle is observed.
Description of drawings
Fig. 1 is the sketch map of a kind of imaging device for biological tissue observation of the present invention;
Fig. 2 is the arrowband multiband LED module principle schematic of a kind of imaging device for biological tissue observation of the present invention;
Fig. 3 is the principle schematic that the arrowband multiband LED module of a kind of imaging device for biological tissue observation of the present invention adds even photosystem;
Fig. 4 is the structural representation that the arrowband multiband LED module of a kind of imaging device for biological tissue observation of the present invention increases protective cover;
Fig. 5 is the work process sketch map of a kind of imaging device for biological tissue observation of the present invention;
Fig. 6 is the brightness control system operation principle sketch map of a kind of imaging device for biological tissue observation of the present invention;
Fig. 7 is the warning system work sketch map of a kind of imaging device for biological tissue observation of the present invention;
Fig. 8 shows sketch map for a kind of imaging device multi-band image for biological tissue observation of the present invention the time.
Numeral and the represented corresponding component title of letter among the figure:
1. high thermal conductive substrate 2.LED chip 3. pins 4. are spared photosystem 5. optical alignment holes 6. line layers, 7. protective covers.
The specific embodiment
The present invention is further detailed explanation below in conjunction with the drawings and specific embodiments.
Embodiment 1,
A kind of imaging device for biological tissue's observation comprises:
Arrowband multiband LED module, described arrowband multiband LED module comprises high thermal conductive substrate and led chip, described high thermal conductive substrate is metal basal board or ceramic substrate, described led chip is the led chip of the different centre wavelengths of at least two groups, the quantity of every group of led chip is at least one, every group of led chip is connected in series, and its wave band is identical or different, and led chip is for being total to anode or common cathode structure; Also be provided with line layer on the described high thermal conductive substrate, between described every group of led chip altogether anode or common cathode be electrically connected, the other end electrode of described every group of led chip draws independently to realize that by described line layer every group of led chip can independently control;
Drive circuit, it provides the working condition of low voltage and high current at described arrowband multiband LED module, can be the accurate control that realizes voltage or electric current;
Even optically coupled device, it provides coupling interface to the light that sends from arrowband multiband LED module, carries out secondary light-distribution;
The transmission optics system, it is transferred to the position that needs illumination with light energy, realizes required illumination zone and the illumination uniformity;
Image signal recording apparatus comprises CCD or cmos imaging element;
The picture signal harvester, it realizes the automatic high speed sampling of digitized signal, and to host computer transmission signal;
Image signal processing apparatus, it generates the picture signal of a plurality of wave bands by reconstruction and the synthetic technology of different-waveband image;
Switching device shifter is realized the switching of arrowband imaging and broadband visual light imaging.
As shown in Figure 1, the operation principle sketch map of arrowband multiband LED module, it specifically comprises high thermal conductive substrate 1 and led chip 2, described led chip 2 is 2 in the LED core of 9 groups of different centre wavelengths, the quantity of described every group of led chip 2 is one, and described led chip 2 is for being total to anode construction; Described led chip 2 directly is fixedly connected on the described high thermal conductive substrate 1; Also be provided with line layer 6 on the described high thermal conductive substrate 1, between described every group of led chip 2 altogether anode be electrically connected, the other end electrode of described every group of led chip 2 draws to realize that by described line layer 6 individual pin 3 every group of led chip 2 can independently control.
Described high thermal conductive substrate 1 is metal basal board, is provided with the insulating barrier (not shown) between described line layer 6 and the metal basal board.
The centre wavelength scope of described 9 led chips 2 contains ultraviolet band to infrared band.
Described every group of led chip 2 is provided with independently control circuit separately and controls separately.Described control circuit comprises the on-off circuit of the connecting and disconnecting of the circuit that can control corresponding group led chip, also comprises the current control circuit of the electrical current size of controlling this group led chip.
In the present embodiment, described independently control circuit is independently controlled, can set up independently circuit to realize, also can be realized by the corresponding integrated circuit of microcomputerized control, the led chip 2 of each different centre wavelength is connected on the different output pin of described independent controling circuit or integrated circuit by being located at independently pin on the line layer 6, realize independently controlling in real time different LED chip 2 with this, can be by connect one or several led chip 2 sometime, remaining led chip 2 is in closed condition, at this moment, the synthetic light of the light that the light of LED module output is sent by the led chip 2 of these energized, thus realized adjusting control to the light source center wavelength.The group number of led chip 2 can be two groups, three groups, four groups, or other any amount, by the integrated led chip of not counting on the same group 2, can realize the different progression of adjusting.Wherein, the quantity of every group of led chip 2 can be 1, also can be 2,3,4, or other any amount, every group of led chip 2 is connected in series, and controlled by the same pin of same control circuit or integrated circuit, the output that this can realize different lumens reaches the brightness that needs.
Adopt the beneficial effect of the technical program to be: owing to adopted the LED module that can realize a plurality of narrow band of light outgoing, thus the use of in described biological tissue observation device, having omitted optical filter and respective fixation anchor clamps thereof.This led light source module comprises the led chip of two groups of different centre wavelengths at least, and to the independent control of led chip employing grouping, realized the multistage adjustable LED luminescence technology of timesharing multiband, can realize the narrow band light outgoing of any a plurality of different centre wavelengths in theory, or the photoreactivation of multiple arrowband is luminous, thereby can pass through described biological tissue observation device, realization from ultraviolet to infrared multiwave imaging, obtain biological tissue's information of different-waveband, realize biological tissue's multiband multi-angle is observed.
As shown in Figure 2, all the other are identical with embodiment 1, difference is, described LED module comprises that also the light exit side that is arranged at described led chip makes light that all led chips penetrate all spare light, make light that each chip sends by the even photosystem 4 of the uniformity of a unified interface outgoing, assurance light beam exit direction and angle by it.Should even photosystem 4 another kind of titles be photo-couplers, should spare the top that photosystem 4 is installed on all led chip light-emitting areas, the light that led chip sends is coupled in the photo-coupler, and light is from its incident end incident, propagate along optical axis, from its exit end outgoing, in this course, the light lighting angle is compressed at last, by repeatedly reflection, the beam projecting uniformity is improved simultaneously.Described photo-coupler can be any one or several combination in integrating rod, reflector and the battery of lens.This also has explanation and description the applicant in a kind of high-brightness LED light supply apparatus of the patent of first to file and a kind of high-brightness LED light source coupler.
Among above-described embodiment 1 and the embodiment 2, described LED module can also have additional protective cover 7, as shown in Figure 3, described protective cover 7 comprise frame and be located on the frame or with frame be holistic transparency window, described protective cover be located at described led chip above.To increase dustproof antifouling and to prevent the led chip accidental damage.
The operation principle of above-described embodiment 1 and embodiment 2 as shown in Figure 4, after this device is started working, at first input obtains the characteristic parameter information of biological tissue, and enter the broadband observation mode, the picture signal of under this kind pattern device being obtained is handled, system can judge pattern switching demand accordingly, if undesired mode switches, then continues to observe with broadband mode; Switch to the arrowband imaging pattern if desired, then switch to according to the preliminary preferred bands of judging of image information, enter the arrowband imaging pattern of this wave band, device carries out analyzing and processing to picture signal under this pattern, judge whether to need to switch the observation wave band, if judged result is true, then switch to corresponding observation wave band, simultaneously, if produce the manual switchover signal, then this manual ringing priority is the highest, switch to this observation wave band, last image optionally is presented on the screen, can show by single width, also can several demonstrations.
In above-described embodiment, described transmission optics system is the combination that requires lens or the optical fiber structure of aspects such as the intensity of illumination that satisfies required illumination position, the uniformity.Can select as required.
Wherein, described transmission optics system and image signal recording apparatus all are positioned at the imaging device inside of biological tissue's observation usefulness, and have the connecting portion that can freely dismantle.
Described image processing apparatus comprises reconstruction and the image processing module and the record that synthesize of realizing image and analyzes a plurality of analysis modules that relate to biological tissue's key index parameter.
Described drive circuit is for realizing the constant-current drive circuit of the operate as normal demand under the big electric current high voltage of LED module.
Described image processing apparatus is provided with the image that can contrast two width of cloth different-wavebands, the multi-band image contrast module that also makes marks, is convenient to image is compared observation automatically to distinguishing tangible position.
The described imaging device of observing for biological tissue also is provided with by the characteristic information of importing observed biological tissue, the information such as colour temperature when also carrying out imaging in conjunction with the employing broadband light, can be adjusted to the picture spectral band automatically, select one or more band of light to carry out imaging, and the imaging wave band of on the display screen panel operator being pointed out is selected module automatically.
On the basis of above-described embodiment, described imaging device for biological tissue observation also is provided with the picture signal that can obtain according to image processing apparatus, judge brightness of image whether at luminance standard with interior and carry out self-adjusting brightness adjusting device according to judged result.
As shown in Figure 5, brightness regulation sketch map for a kind of imaging device for biological tissue observation of the present invention, after device is started working, image processing apparatus can judge whether the brightness of picture signal is fit to observe, if cross bright or dark excessively by inner signal processing, then device passes through control system, curtage to drive circuit is regulated, and by feeding back several times repeatedly, reaches suitable brightness.
Embodiment 4,
On the basis of above-described embodiment, described imaging device for biological tissue's observation also is provided with light energy Threshold Alerts device.
As shown in Figure 6; warning system sketch map for a kind of biological tissue of the present invention observation device; after device is started working; if pattern is in ultraviolet or infrared band, because this wave band has injury effect to human body, therefore; alarm device can monitor ultraviolet at any time or whether infrared band surpasses defined threshold; if surpass threshold value, then will cut off the electricity supply, the protection tissue preserves from.
On the basis of above-described embodiment, described imaging device for biological tissue's observation shows so that the display floater of paired observation and judgement when also being provided with the multi-band image that can realize different colours.
As shown in Figure 7, be the screen display schematic diagram of a kind of biological tissue of the present invention observation device, this screen single image shows, can also select multiple image to show simultaneously, multiple image is shown simultaneously, be conducive to paired observation, obtain contrast clearly, improve the accuracy of medical diagnosis.
Adopt the beneficial effect of technique scheme to be: to adopt arrowband multiband LED die set light source, owing to adopt the led chip of the different centre wavelengths of encapsulation at least two groups, and to the independent control of led chip employing grouping, the present invention has realized the multistage adjustable LED luminescence technology of timesharing multiband, can realize the narrow band light outgoing of any a plurality of different centre wavelengths in theory, or the photoreactivation of multiple arrowband is luminous, realizes multistage adjustable LED light source.
This light supply apparatus can be realized multi-wavelength's imaging, compares existing arrowband imaging technique, and wavelength selectivity is more, has realized biological tissue is more fully observed.
This device has abandoned that traditional performance is low, very flexible, optical filter that cost is high, is conducive to the miniaturization of instrument.
This device has comprised brightness regulating apparatus, alarm device, and the multi-band image Display Technique, more more convenient to operate than prior art safety and reliability, more accurate.
In the present invention, except arrowband multiband LED module, remaining circuit and module all have mature technique in the prior art in corresponding field, are not therefore giving unnecessary details at this.
Above-described only is preferred implementation of the present invention, should be pointed out that for the person of ordinary skill of the art, under the prerequisite that does not break away from the invention design, can also make some distortion and improvement, and these all belong to protection scope of the present invention.
Claims (13)
1. an imaging device that is used for biological tissue's observation is characterized in that, comprising:
Arrowband multiband LED module, described arrowband multiband LED module comprises high thermal conductive substrate and led chip, described high thermal conductive substrate is metal basal board or ceramic substrate, described led chip is the led chip of the different centre wavelengths of at least two groups, the quantity of every group of led chip is at least one, every group of led chip is connected in series, and its wave band is identical or different, and led chip is for being total to anode or common cathode structure; Also be provided with line layer on the described high thermal conductive substrate, between described every group of led chip altogether anode or common cathode be electrically connected, the other end electrode of described every group of led chip draws independently to realize that by described line layer every group of led chip can independently control;
Drive circuit, it provides the working condition of low voltage and high current at described arrowband multiband LED module, can be the accurate control that realizes voltage or electric current;
Even optically coupled device, it provides coupling interface to the light that sends from arrowband multiband LED module, carries out secondary light-distribution;
The transmission optics system, it is transferred to the position that needs illumination with light energy, realizes required illumination zone and the illumination uniformity;
Image signal recording apparatus comprises CCD or cmos imaging element;
The picture signal harvester, it realizes the automatic high speed sampling of digitized signal, and to host computer transmission signal;
Image signal processing apparatus, it generates the picture signal of a plurality of wave bands by reconstruction and the synthetic technology of different-waveband image;
Switching device shifter is realized the switching of arrowband imaging and broadband visual light imaging.
2. the imaging device for biological tissue's observation according to claim 1 is characterized in that the centre wavelength scope of described led chip is that ultraviolet band is to infrared band.
3. the imaging device for biological tissue's observation according to claim 1 is characterized in that, described every group of led chip is provided with independent separately and can controls the connecting and disconnecting of the circuit of corresponding group led chip and the control circuit of size of current.
4. the imaging device for biological tissue's observation according to claim 1 is characterized in that described even optically coupled system is arranged at multiband LED module rear end, arrowband.
5. the imaging device for biological tissue observation according to claim 1 is characterized in that, described transmission optics system is the combination that requires lens or the optical fiber structure of aspects such as the intensity of illumination that satisfies required illumination position, the uniformity.
6. the imaging device for biological tissue's observation according to claim 1 is characterized in that, described transmission optics system and image signal recording apparatus all are positioned at the imaging device inside of biological tissue's observation usefulness, and have the connecting portion that can freely dismantle.
7. the imaging device for biological tissue observation according to claim 1, it is characterized in that, described image processing apparatus comprises reconstruction and the image processing module and the record that synthesize of realizing image and analyzes a plurality of analysis modules that relate to biological tissue's key index parameter.
8. the imaging device for biological tissue's observation according to claim 1 is characterized in that, described drive circuit is for realizing the constant-current drive circuit of the operate as normal demand under the big electric current high voltage of LED module.
9. the imaging device for biological tissue observation according to claim 1, it is characterized in that, described imaging device for biological tissue observation also is provided with the picture signal that can obtain according to image processing apparatus, judge brightness of image whether at luminance standard with interior and carry out self-adjusting brightness adjusting device according to judged result.
10. the imaging device for biological tissue observation according to claim 1, it is characterized in that described image processing apparatus is provided with the image that can contrast two width of cloth different-wavebands, the multi-band image contrast module that also makes marks, is convenient to image is compared observation automatically to distinguishing tangible position.
11. the imaging device for biological tissue's observation according to claim 1, it is characterized in that, the described imaging device of observing for biological tissue also is provided with by the characteristic information of importing observed biological tissue, the information such as colour temperature when also carrying out imaging in conjunction with the employing broadband light, can be adjusted to the picture spectral band automatically, select one or more band of light to carry out imaging, and the imaging wave band of on the display screen panel operator being pointed out is selected module automatically.
12. the imaging device for biological tissue's observation according to claim 1, it is characterized in that described imaging device for biological tissue's observation shows so that the display floater of paired observation and judgement when also being provided with the multi-band image that can realize different colours.
13. the imaging device for biological tissue's observation according to claim 1 is characterized in that, described imaging device for biological tissue's observation also is provided with light energy Threshold Alerts device.
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Application publication date: 20130911 |