CN103006923A - Chinese medicinal liquid band-aid and preparation method - Google Patents
Chinese medicinal liquid band-aid and preparation method Download PDFInfo
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- CN103006923A CN103006923A CN2012105738821A CN201210573882A CN103006923A CN 103006923 A CN103006923 A CN 103006923A CN 2012105738821 A CN2012105738821 A CN 2012105738821A CN 201210573882 A CN201210573882 A CN 201210573882A CN 103006923 A CN103006923 A CN 103006923A
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- chinese medicinal
- radix
- medicinal liquor
- extract
- adhesive bandage
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- 238000002360 preparation method Methods 0.000 title claims description 18
- 239000007788 liquid Substances 0.000 title abstract description 4
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims abstract description 60
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 50
- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 claims abstract description 42
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 21
- NOOLISFMXDJSKH-UHFFFAOYSA-N DL-menthol Natural products CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 claims abstract description 19
- 239000008213 purified water Substances 0.000 claims abstract description 19
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- AXTGDCSMTYGJND-UHFFFAOYSA-N 1-dodecylazepan-2-one Chemical compound CCCCCCCCCCCCN1CCCCCC1=O AXTGDCSMTYGJND-UHFFFAOYSA-N 0.000 claims abstract description 17
- 239000000853 adhesive Substances 0.000 claims description 31
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- IYRMWMYZSQPJKC-UHFFFAOYSA-N kaempferol Chemical compound C1=CC(O)=CC=C1C1=C(O)C(=O)C2=C(O)C=C(O)C=C2O1 IYRMWMYZSQPJKC-UHFFFAOYSA-N 0.000 description 2
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- MWDZOUNAPSSOEL-UHFFFAOYSA-N kaempferol Natural products OC1=C(C(=O)c2cc(O)cc(O)c2O1)c3ccc(O)cc3 MWDZOUNAPSSOEL-UHFFFAOYSA-N 0.000 description 1
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- Medicinal Preparation (AREA)
Abstract
The invention discloses a Chinese medicinal liquid band-aid, and belongs to the technical field of medical care. The band-aid is characterized by comprising the following components in parts by weight: 1 to 15 parts of clover extract, 1 to 10 parts of chitosan, 1 to 25 parts of ethanol, 0.5 to 2 parts of glycerol, 0.5 to 3 parts of hydrogen peroxide, 0.5 to 5 parts of menthol, 1 to 30 purified water, and pharmaceutical grade azone accounting for 0.02 to 2.0 percent of the total amount. The Chinese medicinal liquid band-aid is convenient and easy to use, is not limited by wounds or positions, can be quickly formed into a film after being applied, can be easily permeated and absorbed, has small stimulation to skin of a human body, does not have allergic reaction and drug resistance, and can be used for promoting muscle tissue repair and regeneration and protecting and promoting wound healing to shorten the healing time and effectively solve the problems of wound infection and the like; and the main components of antibacterial and film forming materials of the band-aid are easily degradable and easily absorbable biomaterials, have excellent biocompatibility, can be automatically degraded, and is safe and environment-friendly.
Description
Technical field
The invention belongs to field of medical technology, be specifically related to a kind of Chinese medicinal liquor adhesive bandage and preparation method.
Background technology
Radix Apioris Fortunei (Radix Lespedezae Buergeri)
Tetrastigma hemsleyanum,Sweet in the mouth, cool in nature is vitaceae, has another name called gold thread hoist, stone mouse, Radix Tetrastigmatis Hemsleyani, silk thread and hangs Jin Zhong.The Radix Apioris Fortunei (Radix Lespedezae Buergeri) extract mainly contains flavonoid and flavonoid glycoside, polysaccharide, steroid, cupreol, the ingredients such as kaempferol, triterpenes, alkaloid, have very strong promotion leukocyte and gulp down the function of having a liking for antibacterial, the effects such as refreshing and detoxicating, dispelling pathogenic wind and eliminating phlegm, antiviral, raising immunity are arranged, clinical in diseases such as upper respiratory tract infection, infantile pneumonia, hyperpyrexia convulsion, stomatitis, sore swollen toxin, venoms, be used in the recent period prevention and adjuvant therapy of tumors, hepatitis etc., have widely clinical application.
Radix Apioris Fortunei (Radix Lespedezae Buergeri) is enjoyed the good reputation of bouvardin, and China's application Radix Apioris Fortunei (Radix Lespedezae Buergeri) among the people is treated the with a long history of disease, and the underground avette tuber of fresh Radix Apioris Fortunei (Radix Lespedezae Buergeri) is mashed external application, is used for the treatment of wound and innominate toxic swelling; Levigation after the fresh Radix Apioris Fortunei (Radix Lespedezae Buergeri) tuber lyophilisation, multiplex in wound, get an amount of Radix Apioris Fortunei (Radix Lespedezae Buergeri) dry powder and be spread on the affected part, add wrapping, but hemostasis and anti-inflammation b referred to as a kind of pure natural adhesive bandage, but have the following disadvantages: preserve and use inconvenience, medicated powder easily is scattered and wastes valuable ingredient of Chinese medicine; Wound to privileged sites can't be applied ointment or plaster; Wound can not separate fully with the external world, easily causes wound to infect because of antibacterial, dust or water intrusion.
Summary of the invention
The purpose of this invention is to provide a kind of Radix Apioris Fortunei (Radix Lespedezae Buergeri) that utilizes and be Chinese medicinal liquor adhesive bandage and the preparation method of raw material.
Described a kind of Chinese medicinal liquor adhesive bandage is characterized in that containing following component and ratio of weight and number thereof:
Radix Apioris Fortunei (Radix Lespedezae Buergeri) extract 1-15
Chitosan 1-10
Ethanol 1-25
Glycerol 0.5-2
Hydrogen peroxide 0.5-3
Mentholum 0.5-5
Purified water 1-30
The 0.02-2.0% of pharmaceutical grade azone total amount.
Described a kind of Chinese medicinal liquor adhesive bandage is characterized in that containing following component and ratio of weight and number thereof, makes smear type Chinese medicinal liquor adhesive bandage:
Radix Apioris Fortunei (Radix Lespedezae Buergeri) extract 3-10
Chitosan 1.5
Ethanol 25
Glycerol 1
Hydrogen peroxide 0.5
Mentholum 4
Purified water 6
0.5% of pharmaceutical grade azone total amount.
Described a kind of Chinese medicinal liquor adhesive bandage is characterized in that containing following component and ratio of weight and number, makes aerosol type Chinese medicinal liquor adhesive bandage:
Radix Apioris Fortunei (Radix Lespedezae Buergeri) extract 1-3
Chitosan 1.5
Ethanol 10
Glycerol 0.5
Hydrogen peroxide 0.5
Mentholum 3
Purified water 30
0.5% of pharmaceutical grade azone total amount.
Described a kind of Chinese medicinal liquor adhesive bandage is characterized in that described Radix Apioris Fortunei (Radix Lespedezae Buergeri) extract adopts the following methods preparation:
1) soaked 3～5 minutes with Eusol after the washing of Radix Apioris Fortunei (Radix Lespedezae Buergeri) tuber, then drench Xian with drinking water clean, dry;
2) the Radix Apioris Fortunei (Radix Lespedezae Buergeri) tuber crushing and beating that will dry, serosity is put into the microwave extracting tank, and the purified water that adds equivalent stirs, and opens the extraction of microwave extracting tank and filters to get extract in 3-5 minute;
3) extract is heated to 38-42 ℃, processed 6～8 hours with α-amylase, the starch in the enzymolysis solution gets solution behind the enzymolysis fully;
4) with solution behind the enzymolysis through macroporous resin adsorption, use 50% ethanol elution, is drying to obtain three Folium Isatidis extract dry powder with the pressure type atomizing dryer after eluent filters, it is 5000kpa that the atomization drying temperature is controlled at 45-50 ℃, atomizing pressure.
Described a kind of Chinese medicinal liquor adhesive bandage is characterized in that described ethanol is anhydrous alcohol for medical use or 95% ethanol.
Described a kind of Chinese medicinal liquor adhesive bandage is characterized in that also containing the EGCG of 1-3 weight portion.
Described a kind of Chinese medicinal liquor adhesive bandage is characterized in that also containing the EGCG of 2 weight portions.
The preparation method of described a kind of Chinese medicinal liquor adhesive bandage is characterized in that may further comprise the steps:
1) presses recipe quantity and prepare raw material, purified water is poured in the preparation pot be heated to boiling, add chitosan after being cooled to 88-92 ℃ to be stirred to dissolve complete, then add glycerol and mix, regulate pH value 3.5-5.5, continue to stir 30 minutes, get solution A, be cooled to room temperature for subsequent use;
2) stirring and dissolving under the room temperature in the Radix Apioris Fortunei (Radix Lespedezae Buergeri) extract adding alcoholic solution is complete, get solution B;
3) solution B is joined in the solution A, mix homogeneously adds Mentholum, hydrogen peroxide, pharmaceutical grade azone while stirring, as containing EGCG in the prescription, then adds together, mixes, and namely gets the Chinese medicinal liquor adhesive bandage.
That chitosan in the above-mentioned prescription (D-glucosamine) has is nontoxic, biodegradable, good biocompatibility, preferably antibacterial activity is arranged, and also has good film property.
Glycerol makes antibacterial film soft as medicine film wetting agent in the above-mentioned prescription, is close to the affected part, keeps not dry and cracked coming off; Use biology to refine glycerol except moisturizing, humectation effect, also have the special efficacies such as high activity, antioxidation, better effects if.
Hydrogen peroxide is porogen in the above-mentioned prescription, and hydrogen peroxide disproportionation releasing oxygen and make the antibacterial film pore ventilative adds that dismutation reaction can heat release, can accelerate the antibacterial film curing rate, and hydrogen peroxide also has sterilization.
The chemical name of above-mentioned prescription Chinese medicine level azone: 1-orthododecyl nitrogen heterocyclo heptane-2-ketone, it is a new and effective safety non-toxic Percutaneous absorption enhancer, can increase effective ingredient biological activity and effect, azone itself also has antiviral and bacteriostasis.
Mentholum Chang Zuowei odorant uses in the above-mentioned prescription, acts on skin or mucosa, and refrigerant itching-relieving action is arranged, and produces comfort.
The Radix Apioris Fortunei (Radix Lespedezae Buergeri) extract has antiinflammatory, bactericidal action, and the disinfection sanitizers such as alternative nanometer silver, povidone iodine prepare the liquid adhesive bandage.Utilize Radix Apioris Fortunei (Radix Lespedezae Buergeri) extract biological antibiotic mechanism, can isolate, pathogenic microbe killing (comprising antibacterial, fungus and virus etc.), possess the tissue repair of promotion and regeneration, protection and wound healing shorten healing time.
The Chinese medicinal liquor adhesive bandage that above-mentioned prescription is made, it can be smear type, it also can be aerosol type, all take the Radix Apioris Fortunei (Radix Lespedezae Buergeri) extract as main material, add the Sales polysaccharide, glycerol, hydrogen peroxide, ethanol, Mentholum, purified water etc. are prepared from, it is easy to use, be not subjected to the restriction of wound and lump shape and present position, energy fast filming after the coating, do not affect outward appearance and not limited by the activity of health coating position, overcome the shortcoming of direct use Radix Apioris Fortunei (Radix Lespedezae Buergeri) dry powder, easily osmotic absorption is given full play to the precious Chinese medicine therapeutical effect, stimulate little to human body skin, sensitization not, avirulence, can not produce drug resistance and pollution problem, can effectively protect from infection, play hemostasis, analgesia, sterilization, the effects such as detumescence and raising body's immunity.
The EGCG(epigallocatechin gallate (EGCG) that adds in the above-mentioned prescription) be preservative, skin protectant, prescription adds EGCG and can improve the effect product sterilization skin-care effect.
That the present invention has is easy to use, be not subjected to the restriction of wound and present position, can fast filming after the coating, easily osmotic absorption, to human body skin stimulate little, without anaphylaxis and drug resistance; Promote muscular tissue reparation and regeneration, protection and wound healing shorten healing time, effectively prevent the problems such as wound infection; Its antibiotic and main component filmogen be easily degraded, easy organism-absorbing material, and biocompatibility is good, can degrade voluntarily safety and environmental protection.
The specific embodiment
The present invention is described in further detail below in conjunction with embodiment.
The preparation of Radix Apioris Fortunei (Radix Lespedezae Buergeri) extract: after fresh Radix Apioris Fortunei (Radix Lespedezae Buergeri) tuber water cleaned up, soaked 3-5 minute with the bleaching fluid of germicidal solution 0.05%, then use drinking water drip washing clean, dry; The Radix Apioris Fortunei (Radix Lespedezae Buergeri) tuber crushing and beating that to dry, serosity is put into the microwave extracting tank, and the purified water that adds equivalent stirs, and opens the extraction of microwave extracting tank and filters to get extract in 3-5 minute, and the microwave frequency that microwave tank uses is 2450 MHz; Extract is heated to 38-42 ℃, processed 6～8 hours with α-amylase, the starch in the enzymolysis solution gets solution behind the enzymolysis fully, and heating is beneficial to oozing out of effective ingredient; Solution behind the enzymolysis through macroporous resin adsorption, is used 50% ethanol elution, dry under temperature 45-50 ℃, the condition of atomizing pressure 5000kpa with the pressure type atomizing dryer after eluent filters, namely get three Folium Isatidis extract dry powder, for subsequent use.
Embodiment 1
Weight of material part
Radix Apioris Fortunei (Radix Lespedezae Buergeri) extract 10
Chitosan 1.5
Dehydrated alcohol 25
Glycerol 1
Hydrogen peroxide 0.5
Mentholum 4
Purified water 6
0.5% of pharmaceutical grade azone total amount
Wherein the supplementary materials such as chitosan, ethanol, glycerol, hydrogen peroxide, Mentholum are pharmaceutical grade, during without medicinal rank, require to meet the food grade quality standard.
Preparation method is as follows:
1) presses recipe quantity and prepare raw material, purified water is poured in the preparation pot be heated to boiling, add chitosan after being cooled to 88-92 ℃ to be stirred to dissolve complete, then add glycerol and mix, regulate pH value 3.5-5.5, continue to stir 30 minutes, get solution A, be cooled to room temperature for subsequent use;
2) stirring and dissolving under the room temperature in the Radix Apioris Fortunei (Radix Lespedezae Buergeri) extract adding ethanol solution is complete, get solution B;
3) solution B is joined in the solution A, mix homogeneously adds Mentholum, hydrogen peroxide, pharmaceutical grade azone while stirring, mixes, and namely gets smear type Chinese medicinal liquor adhesive bandage.
Ethanol content is higher in this prescription, and drying and forming-film speed is fast, but zest is large, is fit to the repellent antipruritic without the various sore swollen toxins of wound.
Embodiment 2
Weight of material part
Radix Apioris Fortunei (Radix Lespedezae Buergeri) extract 3
Chitosan 1.5
95% ethanol 10
Glycerol 0.5
Hydrogen peroxide 0.5
Mentholum 3
Purified water 30
0.5% of pharmaceutical grade azone total amount
Wherein the supplementary materials such as chitosan, ethanol, glycerol, hydrogen peroxide, Mentholum are pharmaceutical grade, during without medicinal rank, require to meet the food grade quality standard.
Preparation method is with reference to embodiment 1.The aerosol type Chinese medicinal liquor adhesive bandage of this prescription preparation, ethanol content is low, and essentially no zest is applicable to the impaired diseases of mucosa such as the anti-inflammation and sterilization of wound and oral ulcer.
Embodiment 3
Weight of material part
Radix Apioris Fortunei (Radix Lespedezae Buergeri) extract 3
Chitosan 1.5
Dehydrated alcohol 25
Glycerol 1
Hydrogen peroxide 0.5
Mentholum 4
EGCG 2
Purified water 6
0.5% of pharmaceutical grade azone total amount
Preparation method is as follows:
1) presses recipe quantity and prepare raw material, purified water is poured in the preparation pot be heated to boiling, add chitosan after being cooled to 88-92 ℃ to be stirred to dissolve complete, then add glycerol and mix, regulate pH value 3.5-5.5, continue to stir 30 minutes, get solution A, be cooled to room temperature for subsequent use;
2) stirring and dissolving under the room temperature in the Radix Apioris Fortunei (Radix Lespedezae Buergeri) extract adding ethanol solution is complete, get solution B;
3) solution B is joined in the solution A, mix homogeneously adds Mentholum, hydrogen peroxide, EGCG, pharmaceutical grade azone while stirring, mixes, and namely gets smear type Chinese medicinal liquor adhesive bandage.
Embodiment 4
Weight of material part
Radix Apioris Fortunei (Radix Lespedezae Buergeri) extract 1
Chitosan 1.5
95% ethanol 10
Glycerol 0.5
Hydrogen peroxide 0.5
Mentholum 3
EGCG 2
Purified water 30
0.5% of pharmaceutical grade azone total amount
Preparation method can prepare aerosol type Chinese medicinal liquor adhesive bandage with reference to embodiment 3.
Claims (8)
1. Chinese medicinal liquor adhesive bandage is characterized in that containing following component and ratio of weight and number thereof:
Radix Apioris Fortunei (Radix Lespedezae Buergeri) extract 1-15
Chitosan 1-10
Ethanol 1-25
Glycerol 0.5-2
Hydrogen peroxide 0.5-3
Mentholum 0.5-5
Purified water 1-30
The 0.02-2.0% of pharmaceutical grade azone total amount.
2. a kind of Chinese medicinal liquor adhesive bandage as claimed in claim 1 is characterized in that containing following component and ratio of weight and number thereof, makes smear type Chinese medicinal liquor adhesive bandage:
Radix Apioris Fortunei (Radix Lespedezae Buergeri) extract 3-10
Chitosan 1.5
Ethanol 25
Glycerol 1
Hydrogen peroxide 0.5
Mentholum 4
Purified water 6
0.5% of pharmaceutical grade azone total amount.
3. a kind of Chinese medicinal liquor adhesive bandage as claimed in claim 1 is characterized in that containing following component and ratio of weight and number, makes aerosol type Chinese medicinal liquor adhesive bandage:
Radix Apioris Fortunei (Radix Lespedezae Buergeri) extract 1-3
Chitosan 1.5
Ethanol 10
Glycerol 0.5
Hydrogen peroxide 0.5
Mentholum 3
Purified water 30
0.5% of pharmaceutical grade azone total amount.
4. such as claim 1 or 2 or 3 described a kind of Chinese medicinal liquor adhesive bandages, it is characterized in that described Radix Apioris Fortunei (Radix Lespedezae Buergeri) extract adopts the following methods preparation:
1) soaked 3～5 minutes with Eusol after the washing of Radix Apioris Fortunei (Radix Lespedezae Buergeri) tuber, then drench Xian with drinking water clean, dry;
2) the Radix Apioris Fortunei (Radix Lespedezae Buergeri) tuber crushing and beating that will dry, serosity is put into the microwave extracting tank, and the purified water that adds equivalent stirs, and opens the extraction of microwave extracting tank and filters to get extract in 3-5 minute;
3) extract is heated to 38-42 ℃, processed 6～8 hours with α-amylase, the starch in the enzymolysis solution gets solution behind the enzymolysis fully;
4) with solution behind the enzymolysis through macroporous resin adsorption, use 50% ethanol elution, is drying to obtain three Folium Isatidis extract dry powder with the pressure type atomizing dryer after eluent filters, it is 5000kpa that the atomization drying temperature is controlled at 45-50 ℃, atomizing pressure.
5. such as claim 1 or 2 or 3 described a kind of Chinese medicinal liquor adhesive bandages, it is characterized in that described ethanol is anhydrous alcohol for medical use or 95% ethanol.
6. a kind of Chinese medicinal liquor adhesive bandage as claimed in claim 1 is characterized in that also containing the EGCG of 1-3 weight portion.
7. a kind of Chinese medicinal liquor adhesive bandage as claimed in claim 2 or claim 3 is characterized in that also containing the EGCG of 2 weight portions.
8. the preparation method of a Chinese medicinal liquor adhesive bandage is characterized in that may further comprise the steps:
1) presses recipe quantity and prepare raw material, purified water is poured in the preparation pot be heated to boiling, add chitosan after being cooled to 88-92 ℃ to be stirred to dissolve complete, then add glycerol and mix, regulate pH value 3.5-5.5, continue to stir 30 minutes, get solution A, be cooled to room temperature for subsequent use;
2) stirring and dissolving under the room temperature in the Radix Apioris Fortunei (Radix Lespedezae Buergeri) extract adding alcoholic solution is complete, get solution B;
3) solution B is joined in the solution A, mix homogeneously adds Mentholum, hydrogen peroxide, pharmaceutical grade azone while stirring, as containing EGCG in the prescription, then adds together, mixes, and namely gets the Chinese medicinal liquor adhesive bandage.
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