CN109620945A - A kind of essential oil composition and its preparation method and application suitable for warming up palace, alleviating dysmenorrhea - Google Patents
A kind of essential oil composition and its preparation method and application suitable for warming up palace, alleviating dysmenorrhea Download PDFInfo
- Publication number
- CN109620945A CN109620945A CN201910104643.3A CN201910104643A CN109620945A CN 109620945 A CN109620945 A CN 109620945A CN 201910104643 A CN201910104643 A CN 201910104643A CN 109620945 A CN109620945 A CN 109620945A
- Authority
- CN
- China
- Prior art keywords
- essential oil
- parts
- essential
- bergamot
- oil composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 239000000341 volatile oil Substances 0.000 title claims abstract description 310
- 239000000203 mixture Substances 0.000 title claims abstract description 82
- 206010013935 Dysmenorrhoea Diseases 0.000 title claims abstract description 62
- 208000005171 Dysmenorrhea Diseases 0.000 title claims abstract description 58
- 238000002360 preparation method Methods 0.000 title claims abstract description 21
- 238000010792 warming Methods 0.000 title claims abstract description 10
- 244000179970 Monarda didyma Species 0.000 claims abstract description 48
- 235000010672 Monarda didyma Nutrition 0.000 claims abstract description 48
- 235000011203 Origanum Nutrition 0.000 claims abstract description 43
- 240000000783 Origanum majorana Species 0.000 claims abstract description 43
- 235000006886 Zingiber officinale Nutrition 0.000 claims abstract description 40
- 235000008397 ginger Nutrition 0.000 claims abstract description 40
- 235000010663 Lavandula angustifolia Nutrition 0.000 claims abstract description 37
- 244000178870 Lavandula angustifolia Species 0.000 claims abstract description 36
- 239000001102 lavandula vera Substances 0.000 claims abstract description 36
- 235000018219 lavender Nutrition 0.000 claims abstract description 36
- 241000208152 Geranium Species 0.000 claims abstract description 34
- 244000182022 Salvia sclarea Species 0.000 claims abstract description 31
- 235000002911 Salvia sclarea Nutrition 0.000 claims abstract description 31
- 244000273928 Zingiber officinale Species 0.000 claims abstract description 5
- 244000203593 Piper nigrum Species 0.000 claims description 38
- 235000008184 Piper nigrum Nutrition 0.000 claims description 38
- 235000013614 black pepper Nutrition 0.000 claims description 38
- 235000007866 Chamaemelum nobile Nutrition 0.000 claims description 35
- 235000007232 Matricaria chamomilla Nutrition 0.000 claims description 35
- 241000234314 Zingiber Species 0.000 claims description 35
- 241000723346 Cinnamomum camphora Species 0.000 claims description 33
- 239000007788 liquid Substances 0.000 claims description 23
- 238000000034 method Methods 0.000 claims description 22
- 238000004821 distillation Methods 0.000 claims description 17
- 239000000047 product Substances 0.000 claims description 16
- 238000002156 mixing Methods 0.000 claims description 11
- 239000003921 oil Substances 0.000 claims description 9
- 238000001256 steam distillation Methods 0.000 claims description 8
- 238000004140 cleaning Methods 0.000 claims description 7
- 238000003756 stirring Methods 0.000 claims description 7
- 238000000605 extraction Methods 0.000 claims description 6
- 239000000706 filtrate Substances 0.000 claims description 6
- 238000007789 sealing Methods 0.000 claims description 6
- 239000003480 eluent Substances 0.000 claims description 5
- 238000003815 supercritical carbon dioxide extraction Methods 0.000 claims description 5
- 239000006071 cream Substances 0.000 claims description 3
- 239000000843 powder Substances 0.000 claims description 3
- 239000007921 spray Substances 0.000 claims description 3
- 229940002508 ginger extract Drugs 0.000 claims description 2
- 235000020708 ginger extract Nutrition 0.000 claims description 2
- 244000042664 Matricaria chamomilla Species 0.000 claims 5
- 235000007516 Chrysanthemum Nutrition 0.000 claims 1
- 244000189548 Chrysanthemum x morifolium Species 0.000 claims 1
- 240000003186 Stachytarpheta cayennensis Species 0.000 claims 1
- 235000009233 Stachytarpheta cayennensis Nutrition 0.000 claims 1
- 235000009508 confectionery Nutrition 0.000 claims 1
- 238000003825 pressing Methods 0.000 claims 1
- 238000005406 washing Methods 0.000 claims 1
- 230000000694 effects Effects 0.000 abstract description 38
- 239000003814 drug Substances 0.000 abstract description 18
- 241000721047 Danaus plexippus Species 0.000 abstract description 12
- 210000004291 uterus Anatomy 0.000 abstract description 12
- 240000003538 Chamaemelum nobile Species 0.000 description 30
- 230000000052 comparative effect Effects 0.000 description 24
- 241000700159 Rattus Species 0.000 description 22
- 208000002193 Pain Diseases 0.000 description 17
- 230000036407 pain Effects 0.000 description 17
- 208000005392 Spasm Diseases 0.000 description 13
- 229940079593 drug Drugs 0.000 description 13
- 230000000202 analgesic effect Effects 0.000 description 12
- 208000024891 symptom Diseases 0.000 description 12
- 230000017531 blood circulation Effects 0.000 description 11
- 230000008569 process Effects 0.000 description 11
- 206010028813 Nausea Diseases 0.000 description 10
- 238000012360 testing method Methods 0.000 description 10
- 230000027758 ovulation cycle Effects 0.000 description 9
- 241000283973 Oryctolagus cuniculus Species 0.000 description 7
- 230000003138 coordinated effect Effects 0.000 description 7
- 230000003821 menstrual periods Effects 0.000 description 7
- 230000008693 nausea Effects 0.000 description 7
- 239000000243 solution Substances 0.000 description 7
- XNOPRXBHLZRZKH-UHFFFAOYSA-N Oxytocin Natural products N1C(=O)C(N)CSSCC(C(=O)N2C(CCC2)C(=O)NC(CC(C)C)C(=O)NCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(CCC(N)=O)NC(=O)C(C(C)CC)NC(=O)C1CC1=CC=C(O)C=C1 XNOPRXBHLZRZKH-UHFFFAOYSA-N 0.000 description 6
- 101800000989 Oxytocin Proteins 0.000 description 6
- 102100031951 Oxytocin-neurophysin 1 Human genes 0.000 description 6
- 230000036651 mood Effects 0.000 description 6
- XNOPRXBHLZRZKH-DSZYJQQASA-N oxytocin Chemical compound C([C@H]1C(=O)N[C@H](C(N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CSSC[C@H](N)C(=O)N1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)=O)[C@@H](C)CC)C1=CC=C(O)C=C1 XNOPRXBHLZRZKH-DSZYJQQASA-N 0.000 description 6
- 229960001723 oxytocin Drugs 0.000 description 6
- 239000008280 blood Substances 0.000 description 5
- 238000006243 chemical reaction Methods 0.000 description 5
- 230000007774 longterm Effects 0.000 description 5
- 230000005906 menstruation Effects 0.000 description 5
- 206010012735 Diarrhoea Diseases 0.000 description 4
- 206010015150 Erythema Diseases 0.000 description 4
- 208000012895 Gastric disease Diseases 0.000 description 4
- 206010030113 Oedema Diseases 0.000 description 4
- 206010036618 Premenstrual syndrome Diseases 0.000 description 4
- 210000001015 abdomen Anatomy 0.000 description 4
- 210000004369 blood Anatomy 0.000 description 4
- 238000001816 cooling Methods 0.000 description 4
- 201000010099 disease Diseases 0.000 description 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 4
- 231100000321 erythema Toxicity 0.000 description 4
- 238000002474 experimental method Methods 0.000 description 4
- 238000009472 formulation Methods 0.000 description 4
- 239000011521 glass Substances 0.000 description 4
- 210000004914 menses Anatomy 0.000 description 4
- 230000001737 promoting effect Effects 0.000 description 4
- 230000001105 regulatory effect Effects 0.000 description 4
- 210000002966 serum Anatomy 0.000 description 4
- 206010000060 Abdominal distension Diseases 0.000 description 3
- 241000700199 Cavia porcellus Species 0.000 description 3
- 206010009866 Cold sweat Diseases 0.000 description 3
- 241000196324 Embryophyta Species 0.000 description 3
- 206010020751 Hypersensitivity Diseases 0.000 description 3
- 206010040880 Skin irritation Diseases 0.000 description 3
- 208000007502 anemia Diseases 0.000 description 3
- 239000000730 antalgic agent Substances 0.000 description 3
- 230000002096 anti-tetanic effect Effects 0.000 description 3
- 230000008602 contraction Effects 0.000 description 3
- 239000000463 material Substances 0.000 description 3
- 230000009245 menopause Effects 0.000 description 3
- 208000004296 neuralgia Diseases 0.000 description 3
- 238000000746 purification Methods 0.000 description 3
- 230000004044 response Effects 0.000 description 3
- 231100000475 skin irritation Toxicity 0.000 description 3
- 230000036556 skin irritation Effects 0.000 description 3
- PXGPLTODNUVGFL-BRIYLRKRSA-N (E,Z)-(1R,2R,3R,5S)-7-(3,5-Dihydroxy-2-((3S)-(3-hydroxy-1-octenyl))cyclopentyl)-5-heptenoic acid Chemical compound CCCCC[C@H](O)C=C[C@H]1[C@H](O)C[C@H](O)[C@@H]1CC=CCCCC(O)=O PXGPLTODNUVGFL-BRIYLRKRSA-N 0.000 description 2
- 241000251468 Actinopterygii Species 0.000 description 2
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 2
- 240000007126 Citrus medica var. sarcodactylis Species 0.000 description 2
- 241001672694 Citrus reticulata Species 0.000 description 2
- 208000019255 Menstrual disease Diseases 0.000 description 2
- 241001465754 Metazoa Species 0.000 description 2
- 208000019695 Migraine disease Diseases 0.000 description 2
- 241000208181 Pelargonium Species 0.000 description 2
- 230000036592 analgesia Effects 0.000 description 2
- 230000006378 damage Effects 0.000 description 2
- 230000007812 deficiency Effects 0.000 description 2
- RGLYKWWBQGJZGM-ISLYRVAYSA-N diethylstilbestrol Chemical compound C=1C=C(O)C=CC=1C(/CC)=C(\CC)C1=CC=C(O)C=C1 RGLYKWWBQGJZGM-ISLYRVAYSA-N 0.000 description 2
- 229960000452 diethylstilbestrol Drugs 0.000 description 2
- 208000002173 dizziness Diseases 0.000 description 2
- 235000013399 edible fruits Nutrition 0.000 description 2
- 206010016766 flatulence Diseases 0.000 description 2
- 210000004209 hair Anatomy 0.000 description 2
- 238000010438 heat treatment Methods 0.000 description 2
- 238000011534 incubation Methods 0.000 description 2
- 230000002401 inhibitory effect Effects 0.000 description 2
- 230000000622 irritating effect Effects 0.000 description 2
- CDOSHBSSFJOMGT-UHFFFAOYSA-N linalool Chemical compound CC(C)=CCCC(C)(O)C=C CDOSHBSSFJOMGT-UHFFFAOYSA-N 0.000 description 2
- 239000002075 main ingredient Substances 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 206010027599 migraine Diseases 0.000 description 2
- 210000004877 mucosa Anatomy 0.000 description 2
- 210000003205 muscle Anatomy 0.000 description 2
- 230000008092 positive effect Effects 0.000 description 2
- 201000000484 premenstrual tension Diseases 0.000 description 2
- 238000012545 processing Methods 0.000 description 2
- 238000011084 recovery Methods 0.000 description 2
- 238000007086 side reaction Methods 0.000 description 2
- 230000008326 skin blood flow Effects 0.000 description 2
- 230000016160 smooth muscle contraction Effects 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 238000003786 synthesis reaction Methods 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- 239000001490 (3R)-3,7-dimethylocta-1,6-dien-3-ol Substances 0.000 description 1
- CDOSHBSSFJOMGT-JTQLQIEISA-N (R)-linalool Natural products CC(C)=CCC[C@@](C)(O)C=C CDOSHBSSFJOMGT-JTQLQIEISA-N 0.000 description 1
- 208000004998 Abdominal Pain Diseases 0.000 description 1
- 206010054196 Affect lability Diseases 0.000 description 1
- 206010001928 Amenorrhoea Diseases 0.000 description 1
- 206010002198 Anaphylactic reaction Diseases 0.000 description 1
- WVSBBCCXKUUWGB-ZETCQYMHSA-N COC([C@@H](NCCC)CCO)=O Chemical class COC([C@@H](NCCC)CCO)=O WVSBBCCXKUUWGB-ZETCQYMHSA-N 0.000 description 1
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
- 244000025254 Cannabis sativa Species 0.000 description 1
- 235000008733 Citrus aurantifolia Nutrition 0.000 description 1
- 201000004624 Dermatitis Diseases 0.000 description 1
- 241001151130 Eilema Species 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 1
- 206010022998 Irritability Diseases 0.000 description 1
- 208000007914 Labor Pain Diseases 0.000 description 1
- 208000035945 Labour pain Diseases 0.000 description 1
- 244000041506 Lavandula officinalis Species 0.000 description 1
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 1
- 208000037093 Menstruation Disturbances Diseases 0.000 description 1
- 244000024873 Mentha crispa Species 0.000 description 1
- 235000014749 Mentha crispa Nutrition 0.000 description 1
- 241000699666 Mus <mouse, genus> Species 0.000 description 1
- 241000699670 Mus sp. Species 0.000 description 1
- 240000004371 Panax ginseng Species 0.000 description 1
- 235000005035 Panax pseudoginseng ssp. pseudoginseng Nutrition 0.000 description 1
- 235000003140 Panax quinquefolius Nutrition 0.000 description 1
- 229940123950 Prostaglandin synthase inhibitor Drugs 0.000 description 1
- 241000700157 Rattus norvegicus Species 0.000 description 1
- 241000220317 Rosa Species 0.000 description 1
- 244000143590 Salvia chinensis Species 0.000 description 1
- 235000007154 Salvia chinensis Nutrition 0.000 description 1
- 235000005794 Salvia japonica Nutrition 0.000 description 1
- PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 description 1
- 235000011941 Tilia x europaea Nutrition 0.000 description 1
- 208000025865 Ulcer Diseases 0.000 description 1
- 206010047700 Vomiting Diseases 0.000 description 1
- 208000019790 abdominal distention Diseases 0.000 description 1
- 230000003187 abdominal effect Effects 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 208000026935 allergic disease Diseases 0.000 description 1
- 230000000172 allergic effect Effects 0.000 description 1
- 208000030961 allergic reaction Diseases 0.000 description 1
- 230000007815 allergy Effects 0.000 description 1
- 229940035676 analgesics Drugs 0.000 description 1
- 230000036783 anaphylactic response Effects 0.000 description 1
- 208000003455 anaphylaxis Diseases 0.000 description 1
- 230000003266 anti-allergic effect Effects 0.000 description 1
- 230000000049 anti-anxiety effect Effects 0.000 description 1
- 239000002249 anxiolytic agent Substances 0.000 description 1
- 238000003556 assay Methods 0.000 description 1
- 208000010668 atopic eczema Diseases 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000033228 biological regulation Effects 0.000 description 1
- 210000004204 blood vessel Anatomy 0.000 description 1
- 239000011575 calcium Substances 0.000 description 1
- 229910052791 calcium Inorganic materials 0.000 description 1
- 229910002092 carbon dioxide Inorganic materials 0.000 description 1
- 239000001569 carbon dioxide Substances 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 230000004087 circulation Effects 0.000 description 1
- 238000007803 cold maceration Methods 0.000 description 1
- 230000001934 delay Effects 0.000 description 1
- 230000003111 delayed effect Effects 0.000 description 1
- 230000007682 dermal toxicity Effects 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 229910003460 diamond Inorganic materials 0.000 description 1
- 239000010432 diamond Substances 0.000 description 1
- 230000029087 digestion Effects 0.000 description 1
- 239000012153 distilled water Substances 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 230000008030 elimination Effects 0.000 description 1
- 238000003379 elimination reaction Methods 0.000 description 1
- 238000010828 elution Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 229940011871 estrogen Drugs 0.000 description 1
- 239000000262 estrogen Substances 0.000 description 1
- 210000003414 extremity Anatomy 0.000 description 1
- 208000024756 faint Diseases 0.000 description 1
- 238000011049 filling Methods 0.000 description 1
- 239000012467 final product Substances 0.000 description 1
- 239000000796 flavoring agent Substances 0.000 description 1
- 235000019634 flavors Nutrition 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 239000003205 fragrance Substances 0.000 description 1
- 230000002496 gastric effect Effects 0.000 description 1
- 235000008434 ginseng Nutrition 0.000 description 1
- 210000003714 granulocyte Anatomy 0.000 description 1
- 244000144993 groups of animals Species 0.000 description 1
- 210000001624 hip Anatomy 0.000 description 1
- 229940088597 hormone Drugs 0.000 description 1
- 239000005556 hormone Substances 0.000 description 1
- 230000001900 immune effect Effects 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 230000002045 lasting effect Effects 0.000 description 1
- 238000002386 leaching Methods 0.000 description 1
- 239000004571 lime Substances 0.000 description 1
- 229930007744 linalool Natural products 0.000 description 1
- 210000004705 lumbosacral region Anatomy 0.000 description 1
- 239000011777 magnesium Substances 0.000 description 1
- 229910052749 magnesium Inorganic materials 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 230000002175 menstrual effect Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 210000004400 mucous membrane Anatomy 0.000 description 1
- 210000000754 myometrium Anatomy 0.000 description 1
- 230000000474 nursing effect Effects 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 230000001151 other effect Effects 0.000 description 1
- 230000008506 pathogenesis Effects 0.000 description 1
- 230000000149 penetrating effect Effects 0.000 description 1
- 230000035515 penetration Effects 0.000 description 1
- 239000002304 perfume Substances 0.000 description 1
- 239000002574 poison Substances 0.000 description 1
- 231100000614 poison Toxicity 0.000 description 1
- 230000003389 potentiating effect Effects 0.000 description 1
- 230000036316 preload Effects 0.000 description 1
- 239000002599 prostaglandin synthase inhibitor Substances 0.000 description 1
- 210000003689 pubic bone Anatomy 0.000 description 1
- 230000005855 radiation Effects 0.000 description 1
- 238000011552 rat model Methods 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 230000000306 recurrent effect Effects 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 230000001850 reproductive effect Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 230000029058 respiratory gaseous exchange Effects 0.000 description 1
- 230000033764 rhythmic process Effects 0.000 description 1
- 238000011076 safety test Methods 0.000 description 1
- 230000003248 secreting effect Effects 0.000 description 1
- 210000000697 sensory organ Anatomy 0.000 description 1
- 231100000438 skin toxicity Toxicity 0.000 description 1
- 210000002460 smooth muscle Anatomy 0.000 description 1
- 238000000638 solvent extraction Methods 0.000 description 1
- 230000001148 spastic effect Effects 0.000 description 1
- 235000013599 spices Nutrition 0.000 description 1
- 210000000952 spleen Anatomy 0.000 description 1
- 230000002269 spontaneous effect Effects 0.000 description 1
- 230000006641 stabilisation Effects 0.000 description 1
- 238000011105 stabilization Methods 0.000 description 1
- 238000010025 steaming Methods 0.000 description 1
- 230000003637 steroidlike Effects 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 238000010254 subcutaneous injection Methods 0.000 description 1
- 239000007929 subcutaneous injection Substances 0.000 description 1
- 206010042772 syncope Diseases 0.000 description 1
- 230000009885 systemic effect Effects 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 231100000397 ulcer Toxicity 0.000 description 1
- 230000002485 urinary effect Effects 0.000 description 1
- 210000002700 urine Anatomy 0.000 description 1
- 210000002229 urogenital system Anatomy 0.000 description 1
- 210000003462 vein Anatomy 0.000 description 1
- 238000009423 ventilation Methods 0.000 description 1
- 210000001835 viscera Anatomy 0.000 description 1
- 230000008673 vomiting Effects 0.000 description 1
- 230000003442 weekly effect Effects 0.000 description 1
- 210000002268 wool Anatomy 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/906—Zingiberaceae (Ginger family)
- A61K36/9068—Zingiber, e.g. garden ginger
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/537—Salvia (sage)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/54—Lauraceae (Laurel family), e.g. cinnamon or sassafras
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/67—Piperaceae (Pepper family), e.g. Jamaican pepper or kava
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/752—Citrus, e.g. lime, orange or lemon
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11B—PRODUCING, e.g. BY PRESSING RAW MATERIALS OR BY EXTRACTION FROM WASTE MATERIALS, REFINING OR PRESERVING FATS, FATTY SUBSTANCES, e.g. LANOLIN, FATTY OILS OR WAXES; ESSENTIAL OILS; PERFUMES
- C11B9/00—Essential oils; Perfumes
- C11B9/02—Recovery or refining of essential oils from raw materials
- C11B9/025—Recovery by solvent extraction
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11B—PRODUCING, e.g. BY PRESSING RAW MATERIALS OR BY EXTRACTION FROM WASTE MATERIALS, REFINING OR PRESERVING FATS, FATTY SUBSTANCES, e.g. LANOLIN, FATTY OILS OR WAXES; ESSENTIAL OILS; PERFUMES
- C11B9/00—Essential oils; Perfumes
- C11B9/02—Recovery or refining of essential oils from raw materials
- C11B9/027—Recovery of volatiles by distillation or stripping
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/37—Extraction at elevated pressure or temperature, e.g. pressurized solvent extraction [PSE], supercritical carbon dioxide extraction or subcritical water extraction
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Botany (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Biotechnology (AREA)
- Alternative & Traditional Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Wood Science & Technology (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Dermatology (AREA)
- Medicines Containing Plant Substances (AREA)
- Cosmetics (AREA)
Abstract
The invention discloses a kind of suitable for warming up palace, the essential oil composition for alleviating dysmenorrhea and its preparation method and application.The essential oil composition uses for reference Chinese medicine " monarch " combination principle, it is monarch with Marjoram essential oil, using Lavender, Geranium Essential and Bergamot as minister, it is assistant with clary sage essential oil and ginger essential oil, the essential oil composition that the present invention, which is formed mentioned component compatibility according to reasonable dosage, to be had warm palace, alleviate dysmenorrhea effect, it is not only able to that dysmenorrhea bring sense of discomfort is effectively relieved, moreover it is possible to play the effect in nourishing uterus, warm palace.
Description
Technical field
The present invention relates to nursing materials technical fields, more particularly, to a kind of essential oil suitable for warming up palace, alleviating dysmenorrhea
Composition and its preparation method and application.
Background technique
Dysmenorrhea is one of most common symptom of gynecological patient.Many women have slight discomfort in menstrual period, to numerous women with
Come unnecessary pain and the influence to daily life, work and mood, and with China's expanding economy, women work and life
The realistic problems such as dual-pressure living is big easily cause or aggravate dysmenorrhea.Dysmenorrhea is long-term, recurrent exerbation is not only brought greatly to women
Body and mind pain, often because pain compared with acutely due to influence the normal life and work of patient.
Dysmenorrhea is divided into primary dysmenorrhea and secondary two class, and primary dysmenorrhea refers to pain of the reproductive organs without organic disease
Accounted for 90% or more dysmenorrhea；Acquired dysmenorrhea refers to the dysmenorrhea as caused by pelvic cavity organic disease.Clinical manifestation are as follows: 1. primary
Dysmenorrhea is common in puberty, often falls ill in 1~2 year after first menses；2. pain is mostly since after menstrual onset, appear in earliest through
First 12 hours, to pass through, pain on the 1st was most violent, alleviated after continuing 2~3, pain be often in it is spastic, be located at lower abdomen pubis
On, radiation to lumbosacral regions and femoribus internus；3. can be with the symptoms such as nausea,vomiting,diarrhea, dizziness, out of strength, complexion when serious
Whiten, be in a cold sweat.
Currently, the cause of disease and pathogenesis of dysmenorrhea are not clear, also lack the treatment method of specification.Modern medicine is mainly adopted
With anodyne such as oral prostaglandin synthase inhibitor, non-steroidal drug class drug, spasmolysis and analgesia class drug and calcium and magnesium preparations
Object is treated, though however anodyne can alleviate symptom, it is long-term to rely on that analgesic drug product generate nausea, gastrointestinal mucosa is burst
The side reactions such as ulcer, abdominal pain, granulocyte reduction, and curative effect cannot be lasting, is not suitable for being used for a long time.Therefore, it is necessary to find treatment
The more efficient method of dysmenorrhea.
And essential oil is in the flower from plant, leaf, stem, root or fruit, by steam distillation, squeezing method, cold-maceration or
Solvent extraction method refines the volatile flavor of extraction.Essential oil molecule is superfine, and penetration is high, so can extremely effective disengaging
Body will not remain in vivo according to studies have shown that essential oil as chemicals, it can be by just urine, perspiration, expiration
It is discharged in short time.The study found that gently being massaged with antitetanic essential oil in abdomen, it usually can soon dissolve dysmenorrhea,
And side effect will not be brought.Therefore, alleviate dysmenorrhea using essential oil to be of great significance.
But it is different essential oil and is alleviating dysmenorrhea, antitetanic while may also have a variety of different effects, that is, has
Essential oil can promote the menstrual cycle normal, and what is had can increase menses flow, and some essential oils adjustable menstrual cycle；However
For the women normal or higher through blood flow, to avoid treating dysmenorrhea through this kind of essential oil of blood flow using increase, in order to avoid accidentally
Make to increase through blood flow.Therefore, during alleviating using essential oil product and treating dysmenorrhea, the compatibility kind to essential oil is needed
Class, proportion compatibility and effect carry out system research.
Summary of the invention
The technical problem to be solved by the present invention is to for the technology for alleviating and treating the gynaecological problems such as dysmenorrhea in the prior art
Deficiency, the present invention provide a kind of essential oil composition suitable for warming up palace, alleviating dysmenorrhea.
Another technical problem to be solved by the present invention is that providing the preparation method of the essential oil composition.
The invention solves an also technical problem be to provide the application of the essential oil composition.
The purpose of the present invention is achieved through the following technical solutions:
A kind of essential oil composition suitable for warming up palace, alleviating dysmenorrhea, each component including following parts by weight: ginger extract are provided
Oily 10~30 parts, 10~30 parts of Marjoram essential oil, 10~30 parts of black pepper essential oil, 5~20 parts of Geranium Essential, Rome chamomile
5~20 parts of essential oil, 5~20 parts of clary sage essential oil, 5~20 parts of Bergamot, 1~10 part of Lavender, fragrant camphor tree leaf
1~5 part of essential oil.
Preferably, the essential oil composition includes each component of following parts by weight: 15~25 parts of ginger essential oil, Marjoram essence
Oily 15~25 parts, 15~25 parts of black pepper essential oil, 8~15 parts of Geranium Essential, 8~15 parts of Rome chamomile essential oil, happy mouse
8~15 parts of tail grass essential oil, 8~15 parts of Bergamot, 1~5 part of Lavender, fragrant 1~2 part of essential oil of camphor tree leaf.
It is further preferred that the essential oil composition includes each component of following parts by weight: 15~20 parts of ginger essential oil, horse
15~20 parts of Qiao Lian essential oil, 15~20 parts of black pepper essential oil, 10~15 parts of Geranium Essential, Rome chamomile essential oil 10~15
Part, 10~15 parts of clary sage essential oil, 10~15 parts of Bergamot, 3~5 parts of Lavender, fragrant camphor tree leaf essential oil 1~2
Part.
Most preferably, the essential oil composition includes each component of following parts by weight: 18 parts of ginger essential oil, Marjoram essential oil
18 parts, 16 parts of black pepper essential oil, 12 parts of Geranium Essential, 12 parts of Rome chamomile essential oil, 12 parts of clary sage essential oil, fingered citron
12 parts of mandarin orange essential oil, 3 parts of Lavender, fragrant 1 part of essential oil of camphor tree leaf.
The present invention is according to blending like the principle for closing medicine, it then follows the principle of monarch.Essential oil composition ginseng of the present invention
It is that guidance carries out prescription compatibility according to Chinese medicine " monarch " thought.In the essential oil composition, Marjoram essential oil, which has, promotes flesh
Skin blood circulation, promoting blood circulation and removing obstruction in channels, the effect of relieving pain, also have the function of anti-depression, anti-melancholy, and fragrant odour is pleasant,
It is easy to receive, to no skin irritation, therefore, this composition selects Marjoram essential oil as monarch drug in a prescription.According to " monarch's Ke Ke minister, no
Can by minister institute gram, minister can give birth to monarch, cannot be given birth to by monarch, the monarch and his subjects can than with for use " principle, selection Lavender, India
Certain herbaceous plants with big flowers essential oil and Bergamot are as ministerial drug.Adjutant can help monarch or help minister, the present invention select clary sage essential oil and
Ginger essential oil can play synergy anti-spasm, analgesic effect with main ingredient Marjoram essential oil coordinated as adjutant；It again can be with
Ministerial drug Lavender, Geranium Essential and Bergamot compatibility, have releive, menstruation regulating, warm palace and other effects.
The present invention passes through long term test, and forming the components compatibility according to reasonable dosage has warm palace, alleviates dysmenorrhea
The essential oil composition of effect, the essential oil composition can be applied to massage cream, massage liquid, massage spray etc., and gynecologic patient is long-term
It using the essential oil composition, is not only able to that dysmenorrhea bring sense of discomfort is effectively relieved, moreover it is possible to play the effect in nourishing uterus, warm palace
Fruit.
For further play collaboration warm palace, alleviate dysmenorrhea effect, the essential oil composition also include black pepper essential oil and
Rome chamomile essential oil, with above-mentioned blending prescription compatibility, wherein black pepper essential oil and ginger essential oil coordinated promote blood
Circulation, further functions as warm Gong Xiaoguo, additionally it is possible to anemia caused by being effectively relieved because of dysmenorrhea reaction, diarrhea abdominal distension, muscle acid
Bitterly, the symptoms such as neuralgia, nauseous gastric disorder causing nausea, spasm；Rome chamomile essential oil and Marjoram essential oil, Bergamot etc., which cooperate with, matches
It closes, existing analgesic effect can also play the role of anti-spasm.
The essential oil composition for having warm palace, alleviating dysmenorrhea effect can be adopted under the essential idea of compatibility of the present invention
It is prepared with the existing achievable technological means in this field.
Present invention simultaneously provides the preferred preparation methods of the essential oil composition for having warm palace, alleviating dysmenorrhea effect, are
By Marjoram essential oil, black pepper essential oil, Lavender, fragrant camphor tree leaf essential oil, Geranium Essential, Rome chamomile essential oil, happy
Salvia japonica essential oil, ginger essential oil and Bergamot, after being mixed evenly to get.
It is further preferred that the preparation method of the essential oil composition is: by above-mentioned weight by Marjoram essential oil,
Black pepper essential oil, Lavender and fragrant camphor tree leaf essential oil mixing, stir evenly under conditions of 35 DEG C~40 DEG C, then successively add
Enter Geranium Essential, Rome chamomile essential oil and clary sage essential oil, after being mixed evenly, ginger essential oil and fingered citron is added
Mandarin orange essential oil, under conditions of 35 DEG C~40 DEG C, 12~28h of sealing and standing to get.
Wherein, the Marjoram essential oil in the present invention, black pepper essential oil, Lavender and fragrant camphor tree leaf essential oil are all made of normal pressure
The way of distillation is prepared, and the vapo(u)rizing temperature is 100~120 DEG C.
In addition, the ginger essential oil in the present invention is to obtain ginger powder progress supercritical carbon dioxide extraction；It is described
The pressure of supercritical carbon dioxide extraction is 30~40MPa, and temperature is 60~80 DEG C, and extraction time is 3~4 hours.
Geranium Essential, Rome chamomile essential oil and clary sage essential oil in the present invention are all made of steam distillation
It is prepared, the steam distillation time is 1~6h, and distillation speed is 80~100mL/h.
The extracting method of Bergamot in the present invention are as follows: mature bergamot pericarp is squeezed, is turned when squeezing
Speed be 50~80r/min, bergamot pericarp and eluent after being squeezed, to after the squeezing bergamot pericarp and elution
Liquid is filtered to obtain filtrate and filter residue, and is washed to obtain cleaning solution to filter residue, and obtained filtrate and cleaning solution are mixed
And be centrifugated, layering liquid is obtained after standing, collects the oil phase part point in the layering liquid, as Bergamot.
Present invention simultaneously provides the essential oil compositions for having warm palace, alleviating dysmenorrhea effect in massage cream, massage liquid, presses
The application to rub in spray or sanitary towels.
Compared with prior art, the beneficial effects of the present invention are:
The present invention provides a kind of essential oil compositions suitable for warming up palace, alleviating dysmenorrhea effect, and blending is referring to Chinese medicine " the monarch and his subjects
Assistant makes " combination principle, using Marjoram essential oil as monarch drug in a prescription, using Lavender, Geranium Essential and Bergamot as ministerial drug, with
Clary sage essential oil and ginger essential oil are adjutant, wherein Marjoram essential oil have effects that it is loose, for nervous caused
Positive effect in terms of the moods such as symptom, premenstrual tension PMT, pressure, excited, for menopause, amenorrhoea, menses are insufficient, warp
Preceding symptom etc. is effective；On the other hand, Marjoram essential oil, which also has, promotes skin blood circulation, promoting blood circulation and removing obstruction in channels, lenitive function
Effect.The present invention passes through long term test, has warm palace according to the essential oil composition that reasonable dosage forms the components compatibility, delays
Dysmenorrhea effect is solved, gynecologic patient is used for a long time the essential oil composition, is not only able to that dysmenorrhea bring sense of discomfort is effectively relieved, moreover it is possible to
Play the effect in nourishing uterus, warm palace.
In essential oil composition of the invention also include black pepper essential oil and Rome chamomile essential oil, using rational proportion with it is upper
Blending prescription compatibility is stated, anemia, diarrhea abdominal distension, DOMS, neuralgia, evil caused by capable of being effectively relieved because of dysmenorrhea reaction
The symptoms such as heart gastric disorder causing nausea, spasm, promote blood circulation, and further function as warm Gong Xiaoguo.
The present invention provides a kind of essential oil composition with multiple efficacies, passes through Marjoram essential oil, Lavender, India
Certain herbaceous plants with big flowers essential oil, Bergamot, clary sage essential oil, ginger essential oil, black pepper essential oil, Rome chamomile essential oil and fragrant camphor tree leaf essence
Oily coordinated not only has very strong fat-soluble and penetrating power, is quickly absorbed by body, and there is pungent perfume (or spice) to walk to alter, virtue
Fragrant qi-regulating and promoting blood circulation and stopping pain effect, regulating menoxenia is significant, while can also pass through external medication, simple and efficient, patient acceptance
It is higher.
The preparation method simple process of essential oil composition provided by the invention, it is easy to operate, it is big industrialization can be suitable for
Production improves production efficiency.
Specific embodiment
To facilitate the understanding of the present invention, present invention work more comprehensively, is meticulously described below in conjunction with embodiment, but this hair
Bright protection scope is not limited to embodiment in detail below.
Unless otherwise defined, all technical terms used hereinafter and the normally understood meaning of those skilled in the art
It is identical.Technical term used herein is intended merely to the purpose of description specific embodiment, it is no intended to limit of the invention
Protection scope.
For convenience of description, it is exemplified below heretofore described primary raw material as follows, unless stated otherwise its preparation side
Method is commercially available.Specifically:
Ginger essential oil has analgesia and depth heating effect, and ginger prevents internal organ there are also stimulation cycle system, expansion blood vessel
The characteristics such as spasm and ventilation.Play the role of warm palace, analgesic anti-spasm in inventive formulation, transfers body QI-blood circulation.
Marjoram essential oil is anti-spasm first choice essential oil, has effects that loose, is a kind of potent loosening all muscles agent, can make
Mind & body loosens simultaneously.For the moods side such as nervous caused symptom, premenstrual tension PMT, pressure, excited
Face positive effect.Its in inventive formulation plays the role of anti-spasm analgesic effect as main ingredient and loosens mood.
Anemia caused by black pepper essential oil reacts dysmenorrhea, diarrhea abdominal distension, DOMS, neuralgia, nauseous gastric disorder causing nausea,
The symptoms such as spasm are effective, and black pepper is pungent fragrant class fragrance, and the essential oil of sharp spleen, can promote blood circulation, while can play
Warm Gong Xiaoguo has the function of nourishing uterus.In inventive formulation, with ginger essential oil, Marjoram essential oil coordinated, promote
It is blood circulation, promoting blood circulation and removing obstruction in channels.
Geranium Essential is extraordinary balance essential oil.Possess good adjusting estrogen secreting function, Neng Gouqi
To regulating menoxenia.The present invention is preferably bourbon's Geranium Essential.
Rome chamomile essential oil is a kind of antiallergic essential oil, powerful for skin or the processing of body and mind condition susceptible.In life
In terms of growing urinary system, for climacteric problem, the problem of dysmenorrhea, menstrual period have some setbacks, can act as good result for it.In this hair
In bright formula, also there is antitetanic function with coordinateds, existing analgesic effects such as Marjoram essential oil, Bergamots.
Clary sage essential oil can play analgesic effect, have oestrogen-like hormone, there is menstruation regulating ability.It is played in this formula
Anti-spasm analgesic effect, while in terms of urogenital system, it for dysmenorrhea, labor pain, blood volume is insufficient, menopause the problem of all
Good result can be played, moreover it is possible to it is premenstrual and involutional constrain, feel exhausted and migraine and nervous cause to alleviate the moon
Symptom.
Bergamot has the effects that analgesic, anti-melancholy, anti-spasm, calm, elimination flatulence, and has and people is allowed to feel clear
New happy ability is very suitable to improve the passiveness of dysmenorrhea bring and nervous mood.
Lavender has good remission effect to various pain, more particularly to alleviate gastrospasm, eilema, digestion
The symptoms such as bad, flatulence, nausea.Menses deficiency, dysmenorrhoea can also be effectively relieved, premenstrual symptom, dizziness, migraine etc. have simultaneously
Having can be through effect.The present invention is preferably true Lavender.
Contain the similar left-handed linalool of high concentration in fragrant camphor tree leaf essential oil, equally has effects that loosen body and mind, Ke Yizuo
For E.E.G.There are anti-spasm, antianxiety, slow down the functions such as ballism disease, can be played in inventive formulation and loosen analgesic efficacy, and
The function of thering is drug to guide.Preferably purebred fragrant camphor tree leaf essential oil.
Marjoram essential oil, black pepper essential oil, Lavender in following embodiment, fragrant camphor tree leaf essential oil, Geranium Essential,
Rome chamomile essential oil, clary sage essential oil, ginger essential oil and Bergamot extract by the following method.
Marjoram essential oil: Marjoram flower is cleaned with clear water, after natural drying, is placed in distilling apparatus and is carried out normal pressure steaming
It evaporates, is warming up to 100 DEG C, until cool lime set drop is on a glass, it is oil-free to ooze current stopping distillation, after cooling, condensate liquid is separated
Purification 4 times to get.
Black pepper essential oil: black pepper is placed in distilling apparatus and carries out air-distillation, 105 DEG C are warming up to, until condensing droplet
On a glass, it is oil-free ooze it is current stop distillation, after cooling, to condensate liquid separating-purifying 5 times to get.
Lavender: fresh lavender flower and stem are placed directly within distilling apparatus and carry out air-distillation, heating
To 120 DEG C, until condensing droplet is on a glass, it is oil-free to ooze current stopping distillation, after cooling, to condensate liquid separating-purifying 5 times,
To obtain the final product.
Fragrant camphor tree leaf essential oil: fragrant camphor tree leaf is placed in distilling apparatus and carries out air-distillation, 110 DEG C are warming up to, until condensing droplet exists
On glass plate, it is oil-free ooze it is current stop distillation, after cooling, to condensate liquid separating-purifying 3 times to get.
Geranium Essential: being handled using flower, blade and stem of the steam distillation to fish pelargonium, from seeing
One drop condensing droplet occurs starting timing, after 4h, terminates distillation, distillation speed 90mL/h oozes condensate liquid weight with above-mentioned
0.6 times of anhydrous sodium sulfate is dried, obtain with like rose, spearmint taste light olive-green liquid to get.
Rome chamomile essential oil: being handled Rome chamomile flower using steam distillation, from seeing the first drop
Condensing droplet occurs starting timing, after 3h, terminates distillation, distillation speed 100mL/h, to the above-mentioned condensate liquid purification 4 oozed
It is secondary to get.
Clary sage essential oil: being handled Clary Sage flower and blade using steam distillation, from seeing
First drop condensing droplet occurs starting timing, after 6h, terminates distillation, distillation speed 80mL/h, to the above-mentioned condensate liquid oozed
Purification 3 times to get.
Ginger essential oil: ginger powder progress supercritical carbon dioxide extraction is obtained；Supercritical carbon dioxide fluid extraction
The pressure taken be 30MPa, temperature be 80 DEG C, extraction time be 3 hours to get.
Bergamot: mature bergamot pericarp is squeezed, and revolving speed when squeezing is 50r/min, after obtaining squeezing
Bergamot pericarp and eluent, to after the squeezing bergamot pericarp and eluent be filtered to obtain filtrate and filter residue,
And filter residue is washed to obtain cleaning solution, obtained filtrate and cleaning solution are mixed and is centrifugated, is layered after standing
Liquid, collect the oil phase part point in the layering liquid to get.
Embodiment 1
The present embodiment provides a kind of with warm palace, alleviates the essential oil composition of dysmenorrhea effect, including each of following parts by weight
Component: 10 parts of ginger essential oil, 30 parts of Marjoram essential oil, 10 parts of black pepper essential oil, 5 parts of Geranium Essential, Rome chamomile essential oil 5
Part, 20 parts of clary sage essential oil, 20 parts of Bergamot, 1 part of Lavender, fragrant 5 parts of essential oil of camphor tree leaf.
The above-mentioned preparation method with warm palace, the essential oil composition for alleviating dysmenorrhea effect is: will by above-mentioned weight
Marjoram essential oil, black pepper essential oil, Lavender and fragrant camphor tree leaf essential oil mixing, stir evenly, then under conditions of 35 DEG C
Geranium Essential, Rome chamomile essential oil and clary sage essential oil are sequentially added, after being mixed evenly, ginger essential oil is added
And Bergamot, under conditions of 35 DEG C, sealing and standing 28h to get.
Embodiment 2
The present embodiment provides a kind of with warm palace, alleviates the essential oil composition of dysmenorrhea effect, including each of following parts by weight
Component: 30 parts of ginger essential oil, 10 parts of Marjoram essential oil, 30 parts of black pepper essential oil, 20 parts of Geranium Essential, Rome chamomile essential oil
20 parts, 5 parts of clary sage essential oil, 5 parts of Bergamot, 10 parts of Lavender, fragrant 1 part of essential oil of camphor tree leaf.
The above-mentioned preparation method with warm palace, the essential oil composition for alleviating dysmenorrhea effect is: will by above-mentioned weight
Marjoram essential oil, black pepper essential oil, Lavender and fragrant camphor tree leaf essential oil mixing, stir evenly, then under conditions of 40 DEG C
Geranium Essential, Rome chamomile essential oil and clary sage essential oil are sequentially added, after being mixed evenly, ginger essential oil is added
And Bergamot, under conditions of 40 DEG C, sealing and standing 12h to get.
Embodiment 3
The present embodiment provides a kind of with warm palace, alleviates the essential oil composition of dysmenorrhea effect, including each of following parts by weight
Component: 15 parts of ginger essential oil, 25 parts of Marjoram essential oil, 15 parts of black pepper essential oil, 8 parts of Geranium Essential, Rome chamomile essential oil
15 parts, 8 parts of clary sage essential oil, 8 parts of Bergamot, 5 parts of Lavender, fragrant 2 parts of essential oil of camphor tree leaf.
The above-mentioned preparation method with warm palace, the essential oil composition for alleviating dysmenorrhea effect is: will by above-mentioned weight
Marjoram essential oil, black pepper essential oil, Lavender and fragrant camphor tree leaf essential oil mixing, stir evenly, then under conditions of 36 DEG C
Geranium Essential, Rome chamomile essential oil and clary sage essential oil are sequentially added, after being mixed evenly, ginger essential oil is added
And Bergamot, under conditions of 36 DEG C, sealing and standing 20h to get.
Embodiment 4
The present embodiment provides a kind of with warm palace, alleviates the essential oil composition of dysmenorrhea effect, including each of following parts by weight
Component: 20 parts of ginger essential oil, 20 parts of Marjoram essential oil, 25 parts of black pepper essential oil, 10 parts of Geranium Essential, Rome chamomile essential oil
10 parts, 15 parts of clary sage essential oil, 15 parts of Bergamot, 8 parts of Lavender, fragrant 4 parts of essential oil of camphor tree leaf.
The above-mentioned preparation method with warm palace, the essential oil composition for alleviating dysmenorrhea effect is: will by above-mentioned weight
Marjoram essential oil, black pepper essential oil, Lavender and fragrant camphor tree leaf essential oil mixing, stir evenly, then under conditions of 38 DEG C
Geranium Essential, Rome chamomile essential oil and clary sage essential oil are sequentially added, after being mixed evenly, ginger essential oil is added
And Bergamot, under conditions of 38 DEG C, sealing and standing 16h to get.
Embodiment 5
The present embodiment provides a kind of with warm palace, alleviates the essential oil composition of dysmenorrhea effect, including each of following parts by weight
Component: 18 parts of ginger essential oil, 18 parts of Marjoram essential oil, 16 parts of black pepper essential oil, 12 parts of Geranium Essential, Rome chamomile essential oil
12 parts, 12 parts of clary sage essential oil, 12 parts of Bergamot, 3 parts of Lavender, fragrant 1 part of essential oil of camphor tree leaf.
The preparation method of the above-mentioned essential oil composition for having warm palace, alleviating dysmenorrhea effect is referring to embodiment 2.
Comparative example 1
This comparative example is referring to the process conditions of embodiment 5, and the main distinction is, without Marjoram essence in essential oil composition
Oil.
Comparative example 2
Referring to the process conditions of embodiment 5, the main distinction is this comparative example, and black pepper essential oil is free of in essential oil composition
And ginger essential oil.
Comparative example 3
This comparative example is referring to the process conditions of embodiment 5, and the main distinction is, without black pepper essence in essential oil composition
Oil.
Comparative example 4
Referring to the process conditions of embodiment 5, the main distinction is this comparative example, and ginger essential oil is free of in essential oil composition.
Comparative example 5
Referring to the process conditions of embodiment 5, the main distinction is this comparative example, and Rome chamomile is free of in essential oil composition
Essential oil, Marjoram essential oil and Bergamot.
Comparative example 6
Referring to the process conditions of embodiment 5, the main distinction is this comparative example, and Rome chamomile is free of in essential oil composition
Essential oil.
Comparative example 7
Referring to the process conditions of embodiment 5, the main distinction is this comparative example, and Marjoram essential oil is free of in essential oil composition
And Bergamot.
Comparative example 8
This comparative example is referring to the process conditions of embodiment 5, and the main distinction is, without fish pelargonium essence in essential oil composition
Oil.
Comparative example 9
The process conditions of this comparative example reference embodiment 5, the main distinction are that essential oil composition includes following parts by weight group
Point: 8 parts of ginger essential oil, 35 parts of Marjoram essential oil, 8 parts of black pepper essential oil, 25 parts of Geranium Essential, Rome chamomile essential oil 25
Part, 4 parts of clary sage essential oil, 4 parts of Bergamot, 12 parts of Lavender, fragrant 0.5 part of essential oil of camphor tree leaf.
Comparative example 10
For comparative example 8 referring to the process conditions of embodiment 5, the main distinction is that essential oil composition includes following parts by weight group
Point: 35 parts of ginger essential oil, 9 parts of Marjoram essential oil, 32 parts of black pepper essential oil, 3 parts of Geranium Essential, 4 parts of Rome chamomile essential oil,
21 parts of clary sage essential oil, 22 parts of Bergamot, 0.5 part of Lavender, fragrant 6 parts of essential oil of camphor tree leaf.
Physical and chemical index and sanitary standard detection
By taking the essential oil composition of embodiment 3 as an example, test essential oil composition of the invention whether meet national regulation by
Rub the requirements of essential oil standard GB/T26516~2011.The results are shown in Table 1.
Sense organ, physics and chemistry, the sanitary index of 1 essential oil of table
Test result shows that the present invention has warm palace, alleviates the essential oil composition of dysmenorrhea effect higher than national standard, safety
It is qualified.
Product safety test
By taking the product of embodiment 1 and 5 as an example, toxicity and irritative response of the observation product external application to skin.
1, dermal toxicity test
Healthy adult rabbit is taken, if intact skin and damaged skin group, and respectively set blank control group.Tested essential oil composition
Rabbit is contacted completely and after damaged skin, measurement breathing, heart rate and four limbs activity etc..
As a result with wiping essential oil composition before and comparison among groups, statistically there was no significant difference, also there are no systemic poison
Side reaction.
2, skin irritation test
(1) skin irritation test is carried out using rabbit, divides intact skin group and damage skin group, for 24 hours by rabbit before test
Back backbone diamond wool shaves off, and the essential oil composition prepared respectively with the embodiment of the present invention 1 and 5 connects with the holding of rabbit skin and mucosa
After touching 1d, continuous 7d, whether there is or not the stimulate the reactions such as erythema, oedema for observation skin.
(2) using cavy carry out skin allergy experiment, weekly with the embodiment of the present invention 1 and 5 prepare essential oil composition with
Guinea pig skin mucous membrane is kept in contact 2 times, contacts 4h or more every time, continuous 3 weeks, whether there is or not the allergy such as erythema, oedema are anti-for observation skin
It answers.
Experimental result:
The intact skin and damaged skin of rabbit, remove after being intended for single use or be used for multiple times for 24 hours, respectively at 1,24,48,
72h observation, is showed no erythema and oedema, and stimulate the reaction mean scores are < 0.5, nonirritant.
In guinea pig skin allergic experiment, does not occur the cutaneous anaphylaxises such as the obvious erythema of skin, oedema and other are systemic
Allergic reaction.
Therefore, essential oil composition of the invention will not cause irritative response to rabbit intact skin and damage skin, right
Guinea pig skin has good cutaneous safety without allergic reaction.
Product measure of merit
Mice clinical test is carried out to each embodiment and comparative example, to measure different groups for the therapeutic effect of dysmenorrhea.
1.1 material
1.1.1 animal
Healthy adult female Wistar rats, cleaning grade, 180~200g of weight.
1.1.2 reagent and material
Rat blood serum IFN~kit；IL~4ELISA kit；P of Rats GF2 enzyme-linked immunologic detecting kit；L~essence
Propylhomoserin methyl esters (L~NAME) and Rockwell liquid (Locke's solu~tion)；
1.1.3 instrument
MacLab/4e channel polygraph；
1.2 rat analgesic experiments
1.2.1 rat dysmenorrhea model is established using oxytocin method
Using dysmenorrhea model Isolated Rat Uterus smooth muscle contraction amplitude, frequency as index, Examples 1 to 5 and comparison are evaluated
Influence of the essential oil composition that example 1~10 provides to the smooth musculation of rat uterus
1.2.2 experimental method
The female sd inbred rats that oxytocin induces dysmenorrhea model are randomly divided into 16 groups, every group 10, respectively 1~16 group,
Wherein the 16th group be blank control group, in addition to the 16th group, other rats daily be subcutaneously injected diethylstilbestrol 2mg/kg, continuous 10
It.Since subcutaneous injection diethylstilbestrol the 6th day, 1~5 group give respectively Examples 1 to 5 offer essential oil composition, 6~15
Group gives the essential oil composition of the offer of comparative example 1~10 respectively.16 groups of injection same volume distilled water, continuous 5 days.After the last administration
Oxytocin 20U/kg is injected intraperitoneally in 1h.There is the incubation period of pain reaction (writhing response) in immediate record rat, writhing in 30min
Number calculates the inhibiting rate of writhing number.
Wherein, writhing number inhibiting rate=(model group writhing number-administration group writhing number)/model group writhing number
× 100%.
The above-mentioned rat of PGF2 assay in rat blood serum, injects 30min after oxytocin, etherization, and abdominal vein takes
Blood after processing, measures the content of PGF2 in each group rat blood serum.After above-mentioned animal pattern takes blood simultaneously, rat is taken out rapidly
Palace is placed in cold Rockwell liquid and cleans, and takes every side cornua uteri middle section 2cm, is fixed in the thermostatic bath for filling 10mL Rockwell liquid, with
On MecLab/4e connected tonotransducer.Solution temperature is 37.5~38 DEG C in bath, and constant is passed through 95%O+5%CO
Mixed gas.It adjusts micro actuator and adds preload 1g, balance 40min, restore spontaneous rhythm, contraction frequency and amplitude stabilization to uterus
Afterwards, the contraction frequency and amplitude in groups of animals uterus are recorded.
Influence of 2 drug of table to rat model
Note: the * P < 0.05 compared with blank control group；* P < 0.01.
The essential oil composition that Examples 1 to 5 and blank control group can be seen that Examples 1 to 5 offer from table 2 can
In the significant incubation period for extending rat pain, the writhing number of rat is reduced, this illustrates the essential oil composition tool that Examples 1 to 5 provides
There is significant analgesic effect.
From Examples 1 to 5 as can be seen that the essential oil composition that Examples 1 to 5 provides passes through compared with comparative example 1~10
Marjoram essential oil, Lavender, Geranium Essential, Bergamot, clary sage essential oil, the ginger of extra fine quality number
Essential oil, black pepper essential oil, Rome chamomile essential oil and fragrant camphor tree leaf essential oil coordinated, more preferably to the analgesic effect of rat.
Influence of 3 drug of table to PEG2 in Isolated Rat Uterus contraction frequency and amplitude and serum
From table 3 it is observed that the uterine myometrium frequency of rat is substantially less than blank control in Examples 1 to 5
Group, PGF2αSubstantially less than blank control group, this illustrates that the essential oil composition that Examples 1 to 5 provides can significantly reduce oxytocin
Influence to rat uterus smooth muscle contraction inhibits PEG2 in rat bodyαSynthesis or release, reduce pain.
The essential oil composition that can be seen that Examples 1 to 5 offer compared with comparative example 1~10 from Examples 1 to 5 is logical
Cross Marjoram essential oil, Lavender, Geranium Essential, Bergamot, clary sage essential oil, ginger essential oil, black pepper
Essential oil, Rome chamomile essential oil and fragrant camphor tree leaf essential oil coordinated, more can significantly reduce oxytocin and receive to rat uterus smooth muscle
The influence of contracting inhibits PEG2 in rat bodyαSynthesis or release, reduce pain.
Clinical test
Massage liquid is made in essential oil composition of the invention, has the female patient of dysmenorrhea history on probation through 200 many cases, effectively
Rate reaches 85%, application method are as follows: 3~7 days in menalgia or before menstrual period, massage liquid of the invention is applied to tripe daily
At the Guanyuan point of navel and the lower three cun of underbellies of navel, gently massage 1~3 minute.Select several cases to effect of the invention below
It is described further.
Case 1: it is remaining so-and-so, female is 34 years old, serious using dysmenorrhea before product of the invention, sends out the palace colds such as crymodynia cool with belly
Problem adheres to using product of the present invention after 3 menstrual cycles before menstruation, and dysmenorrhea state is alleviated well, palace cold problem
Improved, physical recovery is normal.
Case 2: Mr. Li, female, 20 years old, before product of the present invention, menstrual period were delayed, and every time it is in the period when, color latent menstruation
Amount is few, and waist soreness adheres to that menstrual period are normal, and menstrual period blood volume and color are just using after 5 menstrual cycles of product of the present invention
Often.
Case 3: Hu, female, 27 years old, using irregular menses before product of the present invention, with lower abdominal distention pain, nauseous gastric disorder causing nausea,
Spasm adheres to that dysmenorrhea state is alleviated well, and physical recovery is normal using after 3 menstrual cycles of product of the present invention.
Case 4: being permitted so-and-so, female, and 25 years old, before product of the present invention, when in the period every time, menstruation block was more, lower abdomen falling inflation,
Pain, irritability, emotional instability adhere to that pain status is alleviated well using after 3 menstrual cycles of product of the present invention,
Mood is improved.
Case 5: Liu, female, 37 years old, before medication, the menstrual cycle was unstable, once in a while menopause, and it is in the period when, cold sweat leaching
It drenches, or even faints, adhere to that the menstrual cycle restores normal, and cold sweat seldom occur in menstrual period using after 8 menstrual cycles of product of the present invention
Dripping state will not faint.
Obviously, above-described embodiment is only intended to clearly illustrate technical solution of the present invention example, and is not
Restriction to embodiments of the present invention.For those of ordinary skill in the art, on the basis of the above description also
It can make other variations or changes in different ways.There is no necessity and possibility to exhaust all the enbodiments.It is all
Made any modifications, equivalent replacements, and improvements etc. within the spirit and principles in the present invention should be included in right of the present invention and want
Within the protection scope asked.
Claims (10)
1. a kind of essential oil composition suitable for warming up palace, alleviating dysmenorrhea, which is characterized in that each component including following parts by weight:
10 ~ 30 parts of ginger essential oil, 10 ~ 30 parts of Marjoram essential oil, 10 ~ 30 parts of black pepper essential oil, 5 ~ 20 parts of Geranium Essential, Rome ocean are sweet
5 ~ 20 parts of chrysanthemum essential oil, 5 ~ 20 parts of clary sage essential oil, 5 ~ 20 parts of Bergamot, 1 ~ 10 part of Lavender, fragrant camphor tree leaf essence
1 ~ 5 part of oil.
2. essential oil composition according to claim 1, which is characterized in that each component including following parts by weight: ginger essential oil
15 ~ 25 parts, 15 ~ 25 parts of Marjoram essential oil, 15 ~ 25 parts of black pepper essential oil, 8 ~ 15 parts of Geranium Essential, Rome chamomile essential oil 8 ~
15 parts, 8 ~ 15 parts of clary sage essential oil, 8 ~ 15 parts of Bergamot, 1 ~ 5 part of Lavender, fragrant 1 ~ 2 part of essential oil of camphor tree leaf.
3. essential oil composition according to claim 1 or claim 2, which is characterized in that each component including following parts by weight: ginger extract
15 ~ 20 parts of oil, 15 ~ 20 parts of Marjoram essential oil, 15 ~ 20 parts of black pepper essential oil, 10 ~ 15 parts of Geranium Essential, Rome chamomile essence
10 ~ 15 parts of oil, 10 ~ 15 parts of clary sage essential oil, 10 ~ 15 parts of Bergamot, 3 ~ 5 parts of Lavender, fragrant camphor tree leaf essential oil 1
~ 2 parts.
4. essential oil composition according to claim 3, which is characterized in that each component including following parts by weight: ginger essential oil
18 parts, 18 parts of Marjoram essential oil, 16 parts of black pepper essential oil, 12 parts of Geranium Essential, 12 parts of Rome chamomile essential oil, happy rat-tail
12 parts of careless essential oil, 12 parts of Bergamot, 3 parts of Lavender, fragrant 1 part of essential oil of camphor tree leaf.
5. any one of according to claim 1 ~ 4 preparation method of the essential oil composition, which is characterized in that by Marjoram essential oil,
Black pepper essential oil, Lavender, fragrant camphor tree leaf essential oil, Geranium Essential, Rome chamomile essential oil, clary sage essential oil, life
Ginger essential oil and Bergamot, after being mixed evenly to get；Preferably, the essential oil composition the preparation method is as follows: pressing
Above-mentioned weight mixes Marjoram essential oil, black pepper essential oil, Lavender and fragrant camphor tree leaf essential oil, at 35 DEG C ~ 40 DEG C
Under conditions of stir evenly, then sequentially add Geranium Essential, Rome chamomile essential oil and clary sage essential oil, mixing and stir
After mixing uniformly, ginger essential oil and Bergamot is added, under conditions of 35 DEG C ~ 40 DEG C, 12 ~ 28 h of sealing and standing to get.
6. the preparation method of essential oil composition according to claim 4, which is characterized in that the Marjoram essential oil, black pepper
Essential oil, Lavender and fragrant camphor tree leaf essential oil are all made of atmospheric distillation and are prepared；Preferably, the vapo(u)rizing temperature be 100 ~
120℃。
7. the preparation method of essential oil composition according to claim 4, which is characterized in that the ginger essential oil is by ginger powder
Supercritical carbon dioxide extraction is carried out to obtain；The pressure of the supercritical carbon dioxide extraction is 30 ~ 40MPa, temperature
Degree is 60 ~ 80 DEG C, and extraction time is 3 ~ 4 hours.
8. the preparation method of essential oil composition according to claim 4, which is characterized in that the Geranium Essential, Luo Mayang
Camomile essential oil and clary sage essential oil are all made of steam distillation and are prepared；Preferably, the steam distillation time
For 1 ~ 6 h, distillation speed is 80 ~ 100mL/h.
9. the preparation method of essential oil composition according to claim 4, which is characterized in that the extraction side of the Bergamot
Method are as follows: squeeze mature bergamot pericarp, revolving speed when squeezing is 50 ~ 80r/min, the bergamot pericarp after being squeezed
And eluent, to after the squeezing bergamot pericarp and eluent be filtered to obtain filtrate and filter residue, and filter residue is carried out
Washing obtains cleaning solution, and obtained filtrate and cleaning solution are mixed and is centrifugated, and layering liquid is obtained after standing, collects described point
Oil phase part point in layer liquid, as Bergamot.
10. a kind of any one according to claim 1 ~ 9 essential oil composition is in massage cream, massage liquid, massage spray or health
Application in towel product.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910104643.3A CN109620945A (en) | 2019-02-01 | 2019-02-01 | A kind of essential oil composition and its preparation method and application suitable for warming up palace, alleviating dysmenorrhea |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910104643.3A CN109620945A (en) | 2019-02-01 | 2019-02-01 | A kind of essential oil composition and its preparation method and application suitable for warming up palace, alleviating dysmenorrhea |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN109620945A true CN109620945A (en) | 2019-04-16 |
Family
ID=66064801
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201910104643.3A Withdrawn CN109620945A (en) | 2019-02-01 | 2019-02-01 | A kind of essential oil composition and its preparation method and application suitable for warming up palace, alleviating dysmenorrhea |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN109620945A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115887606A (en) * | 2022-11-01 | 2023-04-04 | 上海中医药大学 | Compound plant essential oil composition for treating dysmenorrhea caused by cold accumulation, qi stagnation and blood stasis |
| CN118340759A (en) * | 2024-02-19 | 2024-07-16 | 颇黎芳香医药科技（上海）有限公司 | Compound essential oil for relieving primary dysmenorrhea and preparation method thereof |
-
2019
- 2019-02-01 CN CN201910104643.3A patent/CN109620945A/en not_active Withdrawn
Non-Patent Citations (2)
| Title |
|---|
| 圣研考研网: ""2013芳香保健师单方精油培训资料2"", 《HTTP://ALL.100XUEXI.COM/EXAMITEM/EXAMMUSTDETAIL.ASPX?ID=BAADCE5E-7AE8-4870-B09B-5192C9FD7D1C》 * |
| 红柳: "《古代女性花卉养生、养颜秘笈全书》", 30 September 2013, 黑龙江科学技术出版社 * |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115887606A (en) * | 2022-11-01 | 2023-04-04 | 上海中医药大学 | Compound plant essential oil composition for treating dysmenorrhea caused by cold accumulation, qi stagnation and blood stasis |
| CN115887606B (en) * | 2022-11-01 | 2024-03-01 | 上海中医药大学 | Compound plant essential oil composition for dysmenorrhea caused by cold coagulation, qi stagnation and blood stasis |
| CN118340759A (en) * | 2024-02-19 | 2024-07-16 | 颇黎芳香医药科技（上海）有限公司 | Compound essential oil for relieving primary dysmenorrhea and preparation method thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN103520578B (en) | A kind of Chinese medicine composition for the treatment of oral ulcer and preparation method thereof | |
| CN102988264B (en) | Folium Ginkgo freckle removing and whitening frost and preparation method thereof | |
| CN107233412A (en) | It is a kind of to promote compound essential oil composition of sleep and its production and use | |
| CN102397182B (en) | Compound essential oil for improving skin properties | |
| CN105106655B (en) | A kind of prosthetic burn and scald ointment and preparation method thereof | |
| CN102049008A (en) | Traditional Chinese medicine composition for treating chloasma and preparation method thereof | |
| CN110170012A (en) | Compound essential oil and its preparation method and application and pharmaceutical preparation | |
| CN109602888A (en) | A kind of abdomen is releived essential oil composition and massage cream and preparation method thereof | |
| CN103751633A (en) | Traditional Chinese medicinal composition for treating varicose vein of lower limb and preparation method thereof | |
| CN108685769A (en) | A kind of herbal mixture black hair anticreep shampoo and preparation method thereof | |
| CN109620945A (en) | A kind of essential oil composition and its preparation method and application suitable for warming up palace, alleviating dysmenorrhea | |
| CN104857290A (en) | Traditional Chinese medicine disinfection ointment for treating scalds and burns and preparation method thereof | |
| CN104887602B (en) | Jasmine hair washing face washing liquid | |
| CN105832619A (en) | Sterilization and deodorization foot bath salt and preparation method | |
| CN105709020A (en) | Foot bath powder with folium artemisiae argyi decoction dregs and preparation method thereof | |
| CN104689292A (en) | Compound essential oil with refreshing effect and sterilization and disinfection effect | |
| CN102579818A (en) | Traditional Tibetan medicine composition, preparation method thereof and application | |
| KR20110121295A (en) | Composition of external skin preparation for alleviation of menstrual cramp | |
| CN113768803A (en) | Composition of spray for preventing alopecia and removing dandruff and preparation method | |
| CN104922449A (en) | Traditional Chinese medicine disinfection solution and preparation method thereof | |
| CN105342923A (en) | Lipstick for preventing lip chapping and its preparation method | |
| CN105232650B (en) | A kind of ointment that treating scald and its preparation and application | |
| CN104623040A (en) | Nursing composition with wound sterilization and inflammation diminishment effects and preparation method thereof | |
| CN105596742B (en) | A topical Chinese medicinal ointment for treating burn and scald, and its preparation method | |
| CN108815076A (en) | A kind of whitening skin-protection cream and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| WW01 | Invention patent application withdrawn after publication |
Application publication date: 20190416 |
|
| WW01 | Invention patent application withdrawn after publication |